CA2341345C - Dissociation des racemates d'amides primaires catalysee par enzyme - Google Patents
Dissociation des racemates d'amides primaires catalysee par enzyme Download PDFInfo
- Publication number
- CA2341345C CA2341345C CA2341345A CA2341345A CA2341345C CA 2341345 C CA2341345 C CA 2341345C CA 2341345 A CA2341345 A CA 2341345A CA 2341345 A CA2341345 A CA 2341345A CA 2341345 C CA2341345 C CA 2341345C
- Authority
- CA
- Canada
- Prior art keywords
- amine
- ester
- primary amine
- optically active
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
- C12P41/007—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures by reactions involving acyl derivatives of racemic amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
La présente invention concerne un procédé de dissociation des racémates d'amines primaires à substitution alcoxy, par réaction avec un ester, en présence d'une lipase, cette réaction étant suivie de la séparation, de l'acide à l'origine de l'ester, de l'amine optiquement active ainsi formée, puis de la racémisation et du recyclage de l'énantiomère non souhaité de l'amine, ainsi que de l'estérification et du recyclage de l'acide.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19837745.2 | 1998-08-20 | ||
DE19837745A DE19837745A1 (de) | 1998-08-20 | 1998-08-20 | Enzymkatalysierte Racematspaltung von primären Aminen |
PCT/EP1999/005958 WO2000011203A1 (fr) | 1998-08-20 | 1999-08-13 | Dissociation des racemates d'amides primaires catalysee par enzyme |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2341345A1 CA2341345A1 (fr) | 2000-03-02 |
CA2341345C true CA2341345C (fr) | 2010-10-26 |
Family
ID=7878111
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2341345A Expired - Lifetime CA2341345C (fr) | 1998-08-20 | 1999-08-13 | Dissociation des racemates d'amides primaires catalysee par enzyme |
Country Status (12)
Country | Link |
---|---|
US (1) | US6465223B1 (fr) |
EP (1) | EP1119634B1 (fr) |
JP (1) | JP4493851B2 (fr) |
CN (1) | CN1161477C (fr) |
AT (1) | ATE267874T1 (fr) |
AU (1) | AU5516499A (fr) |
BR (1) | BR9913101A (fr) |
CA (1) | CA2341345C (fr) |
DE (2) | DE19837745A1 (fr) |
DK (1) | DK1119634T3 (fr) |
ES (1) | ES2221423T3 (fr) |
WO (1) | WO2000011203A1 (fr) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19956786A1 (de) * | 1999-11-25 | 2001-05-31 | Basf Ag | Verfahren zur Herstellung optisch aktiver Amine |
AU2001294377A1 (en) * | 2000-09-08 | 2002-03-22 | Dsm N.V. | Method for the preparation of enantiomerically enriched amines |
US7951566B2 (en) * | 2005-12-13 | 2011-05-31 | E.I. Du Pont De Nemours And Company | Production of peracids using an enzyme having perhydrolysis activity |
DE102006032061B4 (de) * | 2006-07-11 | 2009-01-02 | Mark, Christoph, Dr. | Verfahren zur Herstellung von optisch aktiven Aminen |
ATE499448T1 (de) * | 2006-09-13 | 2011-03-15 | Basf Se | Verfahren zur herstellung von optisch aktivem 2- benzyloxycyclohexylamin |
WO2023160805A1 (fr) * | 2022-02-25 | 2023-08-31 | Symrise Ag | Parfums à structure méthoxy-acétate |
CN114561440B (zh) * | 2022-04-27 | 2022-07-29 | 天津全和诚科技有限责任公司 | 一种高纯(r)-(+)-1-(4-甲氧基苯)乙胺单体的制备方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4332738A1 (de) * | 1993-09-25 | 1995-03-30 | Basf Ag | Racematspaltung primärer und sekundärer Amine durch Enzym-katalysierte Acylierung |
US6214608B1 (en) * | 1995-02-03 | 2001-04-10 | Basf Aktiengesellschaft | Resolution of racemates of primary and secondary heteroatom-substitued amines by enzyme-catalyzed acylation |
DE19637336A1 (de) * | 1995-12-06 | 1997-06-12 | Bayer Ag | Verfahren zur Herstellung von optisch aktiven Aminen |
DE19603575A1 (de) * | 1996-02-01 | 1997-08-07 | Bayer Ag | Verfahren zur Herstellung von optisch aktiven Aminen |
US5981267A (en) * | 1996-01-24 | 1999-11-09 | The Scripps Research Institute | Enantioselection of amines using homocarbonates with hydrolase |
DE19621686A1 (de) * | 1996-05-30 | 1997-12-04 | Bayer Ag | Verfahren zur Herstellung von optisch aktiven Aminen |
JP2001523969A (ja) * | 1997-05-01 | 2001-11-27 | ジー.ディー.サール アンド カンパニー | キラルベータアミノ酸の製造方法および製造装置 |
DE19727517A1 (de) * | 1997-06-30 | 1999-01-07 | Basf Ag | Racematspaltung von Aminosäureestern durch Enzym-katalysierte Acylierung |
-
1998
- 1998-08-20 DE DE19837745A patent/DE19837745A1/de not_active Withdrawn
-
1999
- 1999-08-13 ES ES99941616T patent/ES2221423T3/es not_active Expired - Lifetime
- 1999-08-13 WO PCT/EP1999/005958 patent/WO2000011203A1/fr active IP Right Grant
- 1999-08-13 EP EP99941616A patent/EP1119634B1/fr not_active Expired - Lifetime
- 1999-08-13 US US09/762,326 patent/US6465223B1/en not_active Expired - Lifetime
- 1999-08-13 BR BR9913101-3A patent/BR9913101A/pt not_active Application Discontinuation
- 1999-08-13 CN CNB99809885XA patent/CN1161477C/zh not_active Expired - Lifetime
- 1999-08-13 DE DE59909610T patent/DE59909610D1/de not_active Expired - Lifetime
- 1999-08-13 CA CA2341345A patent/CA2341345C/fr not_active Expired - Lifetime
- 1999-08-13 AU AU55164/99A patent/AU5516499A/en not_active Abandoned
- 1999-08-13 JP JP2000566455A patent/JP4493851B2/ja not_active Expired - Lifetime
- 1999-08-13 DK DK99941616T patent/DK1119634T3/da active
- 1999-08-13 AT AT99941616T patent/ATE267874T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE19837745A1 (de) | 2000-02-24 |
EP1119634B1 (fr) | 2004-05-26 |
CN1161477C (zh) | 2004-08-11 |
US6465223B1 (en) | 2002-10-15 |
CA2341345A1 (fr) | 2000-03-02 |
AU5516499A (en) | 2000-03-14 |
ATE267874T1 (de) | 2004-06-15 |
JP4493851B2 (ja) | 2010-06-30 |
JP2002523055A (ja) | 2002-07-30 |
CN1313905A (zh) | 2001-09-19 |
WO2000011203A1 (fr) | 2000-03-02 |
EP1119634A1 (fr) | 2001-08-01 |
DE59909610D1 (de) | 2004-07-01 |
DK1119634T3 (da) | 2004-06-28 |
BR9913101A (pt) | 2001-05-08 |
ES2221423T3 (es) | 2004-12-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |
Effective date: 20190813 |