CA2330104A1 - Creation de tissus tridimensionnels - Google Patents

Creation de tissus tridimensionnels Download PDF

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Publication number
CA2330104A1
CA2330104A1 CA002330104A CA2330104A CA2330104A1 CA 2330104 A1 CA2330104 A1 CA 2330104A1 CA 002330104 A CA002330104 A CA 002330104A CA 2330104 A CA2330104 A CA 2330104A CA 2330104 A1 CA2330104 A1 CA 2330104A1
Authority
CA
Canada
Prior art keywords
cells
vascularized
providing
constructs
dimensional tissue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002330104A
Other languages
English (en)
Inventor
Craig R. Halberstadt
Walter D. Holder, Jr.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Charlotte Mecklenburg Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Charlotte Mecklenburg Hospital filed Critical Charlotte Mecklenburg Hospital
Publication of CA2330104A1 publication Critical patent/CA2330104A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/74—Alginate

Abstract

L'invention concerne un procédé d'apport d'un tissu tridimensionnel vascularisé dans un sujet vivant. Le procédé consiste à) à créer à partir d'une matière biocompatible capable de support l'adhésion, la croissance et la migration cellulaires, une construction poreuse contenant des cellules à transplanter et b) à administrer la construction dans une zone d'intérêt dans le sujet vivant pour former un tissu tridimensionnel vascularisé. La construction préférentielle présente une dimension dont la distance de la surface la plus externe au centre de la construction mesure entre environ 50 µm et environ 500 µm. La construction préférentielle présente aussi une structure poreuse interconnectée dont la granulométrie des pores est de l'ordre d'environ 10 µm ne dépassant pas 300µm. Les cellules contenues dans la construction préférentielle ne dépassent pas une distance de 250 µm à partir de la surface externe de la construction.
CA002330104A 1998-04-09 1999-04-09 Creation de tissus tridimensionnels Abandoned CA2330104A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5861998A 1998-04-09 1998-04-09
US09/058,619 1998-04-09
PCT/US1999/007816 WO1999052356A1 (fr) 1998-04-09 1999-04-09 Creation de tissus tridimensionnels

Publications (1)

Publication Number Publication Date
CA2330104A1 true CA2330104A1 (fr) 1999-10-21

Family

ID=22017933

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002330104A Abandoned CA2330104A1 (fr) 1998-04-09 1999-04-09 Creation de tissus tridimensionnels

Country Status (5)

Country Link
EP (1) EP1069822A1 (fr)
JP (1) JP2002511284A (fr)
AU (1) AU3552099A (fr)
CA (1) CA2330104A1 (fr)
WO (1) WO1999052356A1 (fr)

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DE60017900T2 (de) 1999-04-30 2006-04-06 Massachusetts General Hospital, Boston Herstellung von dreidimensionalem vaskularisierten gewebe mittels der verwendung von zweidimensionalen mikrohergestellten formen
AU2004201641B2 (en) * 1999-04-30 2007-04-19 The Charles Stark Draper Laboratory, Inc. Fabrication of Vascularized Tissue Using Microfabricated Two-Dimensional Molds
DE19952847B4 (de) * 1999-10-01 2006-03-23 Minuth, Will, Prof. Dr. Vorrichtung zum Kultivieren und/oder Differenzieren und/oder Halten von Zellen und/oder Geweben
JP2003516364A (ja) * 1999-12-08 2003-05-13 ウラディミロビチ ズィービン，ドミトリー 哺乳動物の生体組織内でカプセルを形成するためのポリアクリルアミドゲルの使用方法、細胞培養方法並びに癌及び真性糖尿病の治療法
CA2408997C (fr) 2000-04-11 2008-08-05 Universitat Heidelberg Revetements et pellicules pour instruments medicaux a base de poly(trifluoro-ethoxyphosphazene)
US7776021B2 (en) 2000-04-28 2010-08-17 The Charles Stark Draper Laboratory Micromachined bilayer unit for filtration of small molecules
US9080146B2 (en) 2001-01-11 2015-07-14 Celonova Biosciences, Inc. Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface
DE10100961B4 (de) 2001-01-11 2005-08-04 Polyzenix Gmbh Körperverträglicher Werkstoff und mit diesem Werkstoff beschichtetes Substrat für die Züchtung von Zellen und künstlichen aus Zellen aufgebauten oder gewachsenen organischen Implantaten
ES2272365T5 (es) 2001-02-13 2011-04-26 Corlife Gbr Matriz de tejido bioartificial vascularizada primariamente y tejido bioartificial vascularizado primariamente.
US7029838B2 (en) * 2001-03-30 2006-04-18 Arizona Board Of Regents On Behalf Of The University Of Arizona Prevascularized contructs for implantation to provide blood perfusion
AU2002331669A1 (en) * 2001-08-23 2003-03-10 The Wistar Institute Of Anatomy And Biology An organotypic intestinal culture and methods of use thereof
AU2003221090C1 (en) * 2002-03-28 2009-11-05 Bridgestone Corporation Tissue engineering scaffold material, artificial vessel, cuff member and coating for implants
ATE439039T1 (de) 2003-01-16 2009-08-15 Gen Hospital Corp Verwendung von dreidimensionalen, mikrogefertigten, mittels gewebetechnologie hergestellten systemen für pharmakologische anwendungen
WO2004072104A2 (fr) * 2003-02-11 2004-08-26 Northwestern University Procedes et matieres pour revetements de surface nanocristallins et liaison de nanofibres d'amphiphiles peptidiques sur ceux-ci
AU2003242464A1 (en) * 2003-06-18 2005-01-04 Hokkaido Technology Licensing Office Co., Ltd. Material for cell adhesion and proliferation
CN1913929A (zh) 2003-12-10 2007-02-14 细胞生物工程公司 用于软组织特征重建的方法和组合物
US20050266556A1 (en) * 2004-02-09 2005-12-01 Yoder Mervin C Isolation, expansion and use of clonogenic endothelial progenitor cells
US20070233274A1 (en) * 2004-04-12 2007-10-04 Hideyuki Miyake Artificial Tissue and Process for Producing the Same
JP4303643B2 (ja) 2004-06-01 2009-07-29 育男 森田 人工組織体およびその製造方法
US9114162B2 (en) 2004-10-25 2015-08-25 Celonova Biosciences, Inc. Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same
US9107850B2 (en) 2004-10-25 2015-08-18 Celonova Biosciences, Inc. Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
US20210299056A9 (en) 2004-10-25 2021-09-30 Varian Medical Systems, Inc. Color-Coded Polymeric Particles of Predetermined Size for Therapeutic and/or Diagnostic Applications and Related Methods
ES2804472T3 (es) * 2005-12-13 2021-02-08 Harvard College Estructuras para trasplante celular
EP1976972B1 (fr) 2006-01-24 2014-03-12 Brown University Dispositif et procédé d'agrégation et d'encapsulation cellulaires
AU2007307715B2 (en) 2006-10-10 2012-08-30 Celonova Biosciences, Inc. Bioprosthetic heart valve with polyphosphazene
US8658851B2 (en) 2006-10-20 2014-02-25 Keracure, Inc. Devices with cells cultured on flexible supports
WO2008112170A1 (fr) 2007-03-09 2008-09-18 Corning Incorporated Matrices de gomme tridimensionnelles pour une culture cellulaire, procédés de fabrication et procédés d'utilisation
JP5024823B2 (ja) * 2007-05-30 2012-09-12 独立行政法人産業技術総合研究所 細胞運動性評価セルチップ
EP2214641A1 (fr) * 2007-10-08 2010-08-11 Sureshan Sivanthan Matrice pouvant être mise à l'échelle pour la culture in vivo d'os et de cartilage
WO2010067904A1 (fr) * 2008-12-12 2010-06-17 国立大学法人東京大学 Procédé de co-culture cellulaire hiérarchique tridimensionnelle
US8501476B2 (en) 2009-10-07 2013-08-06 Brown University Assays and methods for fusing cell aggregates to form proto-tissues
US9243278B2 (en) 2011-09-22 2016-01-26 Brown University Mechanotransduction by the synergistic action of heterotypic cell interactions
US9468680B2 (en) 2011-09-22 2016-10-18 Brown University Differential effects of drugs on transport in a multi-layer 3D spheroid model
CN104244929B (zh) 2012-04-16 2017-04-05 哈佛学院董事会 用于调节免疫反应的介孔二氧化硅组合物
EP3250250A4 (fr) 2015-01-30 2019-05-22 President and Fellows of Harvard College Matériaux péritumoraux et intratumoraux pour traitement anticancéreux
KR102015738B1 (ko) 2015-09-11 2019-08-28 후지필름 가부시키가이샤 젤라틴 구조체 제조 방법, 및 젤라틴 구조체 제조 시스템
EP3411475A4 (fr) 2016-02-06 2019-09-11 President and Fellows of Harvard College Régénération de la niche hématopoïétique pour reconstituer l'immunité
JP2019522486A (ja) 2016-07-13 2019-08-15 プレジデント アンド フェローズ オブ ハーバード カレッジ 抗原提示細胞模倣足場およびそれを作製および使用するための方法

Family Cites Families (1)

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Publication number Priority date Publication date Assignee Title
US5716404A (en) * 1994-12-16 1998-02-10 Massachusetts Institute Of Technology Breast tissue engineering

Also Published As

Publication number Publication date
JP2002511284A (ja) 2002-04-16
EP1069822A1 (fr) 2001-01-24
WO1999052356A1 (fr) 1999-10-21
AU3552099A (en) 1999-11-01

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