CA2322164A1 - Inhibiteurs du transport de la glycine - Google Patents
Inhibiteurs du transport de la glycine Download PDFInfo
- Publication number
- CA2322164A1 CA2322164A1 CA002322164A CA2322164A CA2322164A1 CA 2322164 A1 CA2322164 A1 CA 2322164A1 CA 002322164 A CA002322164 A CA 002322164A CA 2322164 A CA2322164 A CA 2322164A CA 2322164 A1 CA2322164 A1 CA 2322164A1
- Authority
- CA
- Canada
- Prior art keywords
- formula
- butyl
- bis
- fluorophenyl
- piperidinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Abstract
La présente invention concerne l'utilisation des dérivés [4,4-bis(4-fluorophényl)butyl]-1-(pipérazinyles et pipéridyniles), inhibiteurs du transport de la glycine, pour la préparation de médicaments destinés aux traitements des troubles du système nerveux périphérique et du système nerveux central, en particulier, des psychoses, de la douleur, de l'épilepsie, des maladies neurodégénératives (maladie d'Alzheimer), de l'ictus, du trauma crânien, de la sclérose multiple et des troubles de même genre. La présente invention concerne aussi de nouveaux composés, leur préparation et leurs formes galéniques.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98200701 | 1998-03-06 | ||
EP98200701.5 | 1998-03-06 | ||
PCT/EP1999/001309 WO1999044596A2 (fr) | 1998-03-06 | 1999-02-26 | Inhibiteurs du transport de la glycine |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2322164A1 true CA2322164A1 (fr) | 1999-09-10 |
Family
ID=8233444
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002322164A Abandoned CA2322164A1 (fr) | 1998-03-06 | 1999-02-26 | Inhibiteurs du transport de la glycine |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP1059922A2 (fr) |
JP (1) | JP2002505277A (fr) |
KR (1) | KR20010032968A (fr) |
CN (1) | CN1292698A (fr) |
AU (1) | AU3408999A (fr) |
BG (1) | BG104685A (fr) |
BR (1) | BR9907951A (fr) |
CA (1) | CA2322164A1 (fr) |
EE (1) | EE200000482A (fr) |
HR (1) | HRP20000523A2 (fr) |
HU (1) | HUP0101048A2 (fr) |
IL (1) | IL138228A0 (fr) |
NO (1) | NO20004431L (fr) |
PL (1) | PL343435A1 (fr) |
SK (1) | SK13082000A3 (fr) |
TR (1) | TR200002567T2 (fr) |
WO (1) | WO1999044596A2 (fr) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1196410B1 (fr) | 1999-06-28 | 2004-02-18 | Janssen Pharmaceutica N.V. | Inhibiteurs de replication de virus syncytiaux respiratoires |
UA73749C2 (en) * | 1999-11-01 | 2005-09-15 | Diarylenines | |
AU2001254546A1 (en) * | 2000-04-20 | 2001-11-07 | Nps Allelix Corp. | Aminopiperidines |
DE10040016A1 (de) * | 2000-08-16 | 2002-02-28 | Boehringer Ingelheim Pharma | Neue beta-Amyloid Inhibitoren, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel |
WO2002019967A2 (fr) | 2000-09-08 | 2002-03-14 | Gliatech, Inc. | Derives hydraziniques substitues |
WO2002022581A1 (fr) * | 2000-09-14 | 2002-03-21 | Gliatech, Inc. | Composes azotes et leur utilisation comme inhibiteurs de transport de la glycine |
AR032653A1 (es) | 2001-02-09 | 2003-11-19 | Telik Inc | Inhibidores heterociclicos del trasportador de glicina 2 composiciones farmaceuticas, uso y metodos. |
US7030150B2 (en) | 2001-05-11 | 2006-04-18 | Trimeris, Inc. | Benzimidazole compounds and antiviral uses thereof |
DE602004020674D1 (de) | 2003-09-09 | 2009-05-28 | Hoffmann La Roche | 1-benzoyl-piperazin-derivate als glycin-aufnahmehemmer zur behandlung von psychosen |
WO2005023260A1 (fr) | 2003-09-09 | 2005-03-17 | F. Hoffmann-La Roche Ag | Derives de 1-(2-amino-benzol)-piperazine en tant qu'inhibiteurs de l'absorption du glycocolle pour traiter des psychoses |
WO2005058885A2 (fr) * | 2003-12-18 | 2005-06-30 | Glaxo Group Limited | Composes |
TW200630337A (en) | 2004-10-14 | 2006-09-01 | Euro Celtique Sa | Piperidinyl compounds and the use thereof |
DE602005014274D1 (de) * | 2004-12-09 | 2009-06-10 | Hoffmann La Roche | Phenylpiperazin-methanon-derivate |
JP4709849B2 (ja) * | 2004-12-15 | 2011-06-29 | エフ.ホフマン−ラ ロシュ アーゲー | アルツハイマー病治療のためのグリシントランスポーターi(glyt−1)インヒビターとしての二環式及び三環式置換フェニルメタノン類 |
PE20061156A1 (es) | 2004-12-23 | 2006-12-16 | Glaxo Group Ltd | Derivados de benzamida como agentes inhibidores del transportador de glicina |
GB0428233D0 (en) * | 2004-12-23 | 2005-01-26 | Glaxo Group Ltd | Compounds |
US7485637B2 (en) | 2005-01-04 | 2009-02-03 | Hoffmann-La Roche Inc. | Benzoyl-tetrahydropiperidine derivatives |
BRPI0519744A2 (pt) * | 2005-01-06 | 2009-03-10 | Hoffmann La Roche | metanonas de fenila substituÍda por sulfanila como inibidores de transportador de glicina 1 (glyt-1) para o tratamento de distérbios neurolàgicos e neuropsiquiÁtricos |
BRPI0519794A2 (pt) * | 2005-01-07 | 2009-03-17 | Hoffmann La Roche | derivados de [4-(heteroaril)piperazin-1-il]-(fenil 2,5-substituìdo)metanona como inibidores de transportador de glicina 1 (glyt-1) para o tratamento de distúrbios neurológicos e neuropsiquiátricos |
CA2601326A1 (fr) * | 2005-01-18 | 2006-07-27 | F.Hoffmann-La Roche Ag | Derives de phenylmethanone disubstitues en 2, 5 en tant qu'inhibiteurs du transporteur 1 de la glycine (glyt-i) pour le traitement de troubles neurologiques et neuropsychiatriques |
ES2332529T3 (es) | 2005-01-26 | 2010-02-08 | F. Hoffmann-La Roche Ag | Derivados de fenil-metanona y su empleo como inhibidores del transportador 1 de glicina. |
RS51204B (sr) | 2005-02-07 | 2010-12-31 | F. Hoffmann-La Roche Ag. | Heterociklični supstituisani fenil metanoni kao inhibitori glicin transportera 1 |
CN100341871C (zh) * | 2005-06-03 | 2007-10-10 | 复旦大学 | 含哌啶结构的有机硫化合物,制备方法和应用 |
US8247442B2 (en) | 2006-03-29 | 2012-08-21 | Purdue Pharma L.P. | Benzenesulfonamide compounds and their use |
TW200812963A (en) | 2006-04-13 | 2008-03-16 | Euro Celtique Sa | Benzenesulfonamide compounds and the use thereof |
US8791264B2 (en) | 2006-04-13 | 2014-07-29 | Purdue Pharma L.P. | Benzenesulfonamide compounds and their use as blockers of calcium channels |
KR20120031245A (ko) * | 2006-11-01 | 2012-03-30 | 퍼듀 퍼머 엘피 | 페닐프로피온아미드 화합물 및 그의 용도 |
FR2910320B1 (fr) * | 2006-12-21 | 2009-02-13 | Galderma Res & Dev S N C Snc | Emulsion comprenant au moins un retinoide et du peroxyde de benzole |
FR2910321B1 (fr) | 2006-12-21 | 2009-07-10 | Galderma Res & Dev S N C Snc | Gel creme comprenant au moins un retinoide et du peroxyde de benzole |
US8399486B2 (en) | 2007-04-09 | 2013-03-19 | Purdue Pharma L.P. | Benzenesulfonyl compounds and the use thereof |
WO2009040659A2 (fr) | 2007-09-28 | 2009-04-02 | Purdue Pharma L.P. | Composés benzènesulfonamides et leurs utilisations |
JP2011506441A (ja) * | 2007-12-12 | 2011-03-03 | アムジエン・インコーポレーテツド | グリシン輸送体−1阻害薬 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4219559A (en) * | 1979-01-10 | 1980-08-26 | Janssen Pharmaceutica N.V. | N-Heterocyclyl-4-piperidinamines |
CA1140119A (fr) * | 1978-04-03 | 1983-01-25 | Joseph Torremans | Nouvelles n-heterocycle-4-piperidinamines |
US4695575A (en) * | 1984-11-13 | 1987-09-22 | Janssen Pharmaceutica, N.V. | 4-[(bicycle heterocyclyl)-methyl and -hetero]-piperidines |
PH23995A (en) * | 1984-01-09 | 1990-02-09 | Janssen Pharmaceutica Nv | 4((bicycle heterocyclyl)-methyl and hetero)piperidines |
AU1041599A (en) * | 1997-11-13 | 1999-06-07 | Jose Luis Castro Pineiro | Therapeutic uses of triazolo-pyridazine derivatives |
-
1999
- 1999-02-26 PL PL99343435A patent/PL343435A1/xx not_active Application Discontinuation
- 1999-02-26 JP JP2000534198A patent/JP2002505277A/ja not_active Withdrawn
- 1999-02-26 EE EEP200000482A patent/EE200000482A/xx unknown
- 1999-02-26 EP EP99915541A patent/EP1059922A2/fr not_active Withdrawn
- 1999-02-26 HU HU0101048A patent/HUP0101048A2/hu unknown
- 1999-02-26 BR BR9907951-8A patent/BR9907951A/pt not_active Application Discontinuation
- 1999-02-26 TR TR2000/02567T patent/TR200002567T2/xx unknown
- 1999-02-26 WO PCT/EP1999/001309 patent/WO1999044596A2/fr not_active Application Discontinuation
- 1999-02-26 CA CA002322164A patent/CA2322164A1/fr not_active Abandoned
- 1999-02-26 KR KR1020007006315A patent/KR20010032968A/ko not_active Application Discontinuation
- 1999-02-26 CN CN998036471A patent/CN1292698A/zh active Pending
- 1999-02-26 IL IL13822899A patent/IL138228A0/xx unknown
- 1999-02-26 SK SK1308-2000A patent/SK13082000A3/sk unknown
- 1999-02-26 AU AU34089/99A patent/AU3408999A/en not_active Abandoned
-
2000
- 2000-08-02 HR HR20000523A patent/HRP20000523A2/hr not_active Application Discontinuation
- 2000-08-11 BG BG104685A patent/BG104685A/xx unknown
- 2000-09-05 NO NO20004431A patent/NO20004431L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
HRP20000523A2 (en) | 2001-02-28 |
EE200000482A (et) | 2002-02-15 |
KR20010032968A (ko) | 2001-04-25 |
HUP0101048A2 (hu) | 2001-10-28 |
CN1292698A (zh) | 2001-04-25 |
IL138228A0 (en) | 2001-10-31 |
NO20004431D0 (no) | 2000-09-05 |
NO20004431L (no) | 2000-10-30 |
SK13082000A3 (sk) | 2001-03-12 |
JP2002505277A (ja) | 2002-02-19 |
WO1999044596A3 (fr) | 2000-02-17 |
EP1059922A2 (fr) | 2000-12-20 |
WO1999044596A2 (fr) | 1999-09-10 |
TR200002567T2 (tr) | 2000-11-21 |
BG104685A (en) | 2001-04-30 |
BR9907951A (pt) | 2001-01-30 |
PL343435A1 (en) | 2001-08-13 |
AU3408999A (en) | 1999-09-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2322164A1 (fr) | Inhibiteurs du transport de la glycine | |
CA2322136A1 (fr) | Inhibiteurs du transport de la glycine | |
US5817677A (en) | 5-membered heterocycles, medicaments containing these compounds, their use and processes for their preparation | |
JP3989444B2 (ja) | 新規な化合物 | |
US20050256159A1 (en) | 1,4-disubstituted piperidine derivatives and their use as 11,betahsd1 inhibitors | |
EP2066659B1 (fr) | Dérivés de sulfonamides substitués | |
RU2332412C2 (ru) | Производные пиразола | |
EP0608858A1 (fr) | Dérivés hétérocycliques à 5 chaînons comme inhibiteurs d'aguégation | |
KR20060095865A (ko) | 글리신 수송 억제제로서의 비시클릭 [3.1.0] 유도체 | |
JP2010520876A (ja) | ピペラジンおよびピペリジンmGluR5増強剤 | |
EA001559B1 (ru) | Производные 1-(1,2-дизамещенный пиперидинил)-4-замещенного пиперидина как антагонисты рецепторов тахикинина | |
NO310232B1 (no) | 1-(1,2-disubstituert piperidinyl)-4-substituerte piperazinderivater | |
JP5841617B2 (ja) | アルファ7nAChRのアロステリック調節因子としての(ピリジン−4−イル)ベンジルアミド | |
JP2005506330A (ja) | ケモカイン(特にccr3)活性のモジュレーターとしてのピペリジン誘導体およびその使用 | |
AU2016320645B2 (en) | Fluoroindole derivatives as muscarinic M1 receptor positive allosteric modulators | |
KR20170040803A (ko) | 아제티디닐옥시페닐피롤리딘 화합물 | |
DE60024120T2 (de) | Substituierte (aminoiminomethyl oder aminomethyl) dihydrobenzofurane und benozopyrane | |
US20110318266A1 (en) | Phthalimide derivative metabotropic glutamate r4 ligands | |
EP0285219A2 (fr) | Méthode pour améliorer le sommeil | |
EP4289425A2 (fr) | Nouveaux dérivés de benzimidazole substitués utilisés en tant qu'inhibiteurs de la d-amino-acide oxydase (daao) | |
TWI449700B (zh) | 作為組織胺h3受體拮抗劑之三亞甲亞胺類 | |
MXPA00008690A (en) | Glycine transport inhibitors | |
CZ20003146A3 (cs) | Inhibitory přenosu glycinu | |
JP7034284B2 (ja) | ムスカリン性m1受容体ポジティブアロステリックモジュレーターとしての置換アザ環 | |
EP4159718A1 (fr) | Dérivé de sulfonamide et composition pharmaceutique le comprenant en tant que principe actif pour la prévention ou le traitement d'une maladie mentale |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |