CA2310621A1 - Procede d'evaluation des effets toxiques et pathologiques de stimuli environnementaux sur la transcription des genes - Google Patents

Procede d'evaluation des effets toxiques et pathologiques de stimuli environnementaux sur la transcription des genes Download PDF

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Publication number
CA2310621A1
CA2310621A1 CA002310621A CA2310621A CA2310621A1 CA 2310621 A1 CA2310621 A1 CA 2310621A1 CA 002310621 A CA002310621 A CA 002310621A CA 2310621 A CA2310621 A CA 2310621A CA 2310621 A1 CA2310621 A1 CA 2310621A1
Authority
CA
Canada
Prior art keywords
genes
gene
mammal
mrna
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002310621A
Other languages
English (en)
Inventor
Timothy Bertram
Michael J. Browne
Peter Bugelski
Paul England
Ian Mitchell
Andrew Rut
David Gwyn Morgan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
SmithKline Beecham Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2310621A1 publication Critical patent/CA2310621A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention porte sur un procédé d'évaluation des effets pathologiques de stimuli ou de réactifs environnementaux sur des cellules de mammifère par identification sur une grille d'ADN d'un motif d'hybridation en forme "d'empreinte digitale". Ledit motif est caractéristique de différents stimuli ou réactifs environnementaux chimiques ou structurels présentant un effet adverse commun sur la transcription des gènes. Différentes substances expérimentales sont testées pour rechercher un effet toxique similaire en comparant leur motif d'hybridation sur une grille similaire avec l'empreinte digitale.
CA002310621A 1997-11-20 1998-11-20 Procede d'evaluation des effets toxiques et pathologiques de stimuli environnementaux sur la transcription des genes Abandoned CA2310621A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6624197P 1997-11-20 1997-11-20
US60/066,241 1997-11-20
PCT/GB1998/003445 WO1999027090A1 (fr) 1997-11-20 1998-11-20 Procede d'evaluation des effets toxiques et pathologiques de stimuli environnementaux sur la transcription des genes

Publications (1)

Publication Number Publication Date
CA2310621A1 true CA2310621A1 (fr) 1999-06-03

Family

ID=22068220

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002310621A Abandoned CA2310621A1 (fr) 1997-11-20 1998-11-20 Procede d'evaluation des effets toxiques et pathologiques de stimuli environnementaux sur la transcription des genes

Country Status (5)

Country Link
EP (1) EP1032663A1 (fr)
JP (1) JP2001524311A (fr)
AU (1) AU1166199A (fr)
CA (1) CA2310621A1 (fr)
WO (1) WO1999027090A1 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6593084B2 (en) * 1998-10-13 2003-07-15 Robert E. Bird Carcinogen assay
US6852845B1 (en) * 1999-11-22 2005-02-08 Curagen Corporation Method of identifying toxic agents using NSAID-induced differential gene expression in liver
EP1290443A1 (fr) * 2000-06-14 2003-03-12 Vistagen, Inc. Typage de toxicite au moyen de cellules souches mesenchymateuses
US20020012905A1 (en) * 2000-06-14 2002-01-31 Snodgrass H. Ralph Toxicity typing using liver stem cells
US7590493B2 (en) 2000-07-31 2009-09-15 Ocimum Biosolutions, Inc. Methods for determining hepatotoxins
JP2002065259A (ja) * 2000-08-24 2002-03-05 Shinya Watanabe 核酸標識方法および核酸標識用キット
FR2819524B1 (fr) * 2001-01-18 2003-07-04 Antonios Vekris Hybridation differentielle par competition
US20020192671A1 (en) * 2001-01-23 2002-12-19 Castle Arthur L. Method and system for predicting the biological activity, including toxicology and toxicity, of substances
CA2447357A1 (fr) * 2001-05-22 2002-11-28 Gene Logic, Inc. Modelisation en toxicologie moleculaire
KR20020096559A (ko) * 2001-06-21 2002-12-31 이준호 알코올에 의해 특이적으로 그 전사발현이 유도되거나저해되는 알코올 민감성 유전자 발굴
JP2005517400A (ja) * 2001-07-10 2005-06-16 ジーン ロジック インコーポレイテッド 心臓毒分子毒性モデリング
US7447594B2 (en) 2001-07-10 2008-11-04 Ocimum Biosolutions, Inc. Molecular cardiotoxicology modeling
EP1921157B1 (fr) * 2001-08-24 2010-05-26 Daikin Industries, Ltd. Processus de détection de substances toxiques
JP2005535285A (ja) * 2002-01-31 2005-11-24 ジーン ロジック インコーポレイテッド 分子肝毒性モデリング
US7469185B2 (en) 2002-02-04 2008-12-23 Ocimum Biosolutions, Inc. Primary rat hepatocyte toxicity modeling
WO2004009765A2 (fr) * 2002-07-19 2004-01-29 Althea Technologies, Inc. Strategies pour l'analyse de l'expression genique
AU2003284921A1 (en) * 2002-10-22 2004-05-13 Iconix Pharmaceuticals, Inc. Reticulocyte depletion signatures
EP1654536A4 (fr) * 2003-08-07 2008-07-30 Ocimum Biosolutions Inc Modelisation de toxicite d'hepatocyte primaire chez le rat

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2111289T5 (es) * 1993-01-21 2005-07-16 President And Fellows Of Harvard College Metodos y kits de diagnostico que emplean promotores de estres en mamiferos para determinar la toxicidad de un compuesto.
WO1997013877A1 (fr) * 1995-10-12 1997-04-17 Lynx Therapeutics, Inc. Mesure de profils d'expression genique pour evaluer la toxicite
US6156502A (en) * 1995-12-21 2000-12-05 Beattie; Kenneth Loren Arbitrary sequence oligonucleotide fingerprinting

Also Published As

Publication number Publication date
JP2001524311A (ja) 2001-12-04
WO1999027090A1 (fr) 1999-06-03
EP1032663A1 (fr) 2000-09-06
AU1166199A (en) 1999-06-15

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