CA2304396A1 - A pharmaceutical preparation comprising vitamin k-dependent single factors - Google Patents
A pharmaceutical preparation comprising vitamin k-dependent single factors Download PDFInfo
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- CA2304396A1 CA2304396A1 CA002304396A CA2304396A CA2304396A1 CA 2304396 A1 CA2304396 A1 CA 2304396A1 CA 002304396 A CA002304396 A CA 002304396A CA 2304396 A CA2304396 A CA 2304396A CA 2304396 A1 CA2304396 A1 CA 2304396A1
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- preparation
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- 108010048049 Factor IXa Proteins 0.000 description 1
- 101150096839 Fcmr gene Proteins 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 239000000899 Gutta-Percha Substances 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 101150051715 Phax gene Proteins 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 241000282312 Proteles Species 0.000 description 1
- 101150107341 RERE gene Proteins 0.000 description 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 1
- 108091006629 SLC13A2 Proteins 0.000 description 1
- 108010022999 Serine Proteases Proteins 0.000 description 1
- 102000012479 Serine Proteases Human genes 0.000 description 1
- 101710172711 Structural protein Proteins 0.000 description 1
- 206010047249 Venous thrombosis Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- OJYGBLRPYBAHRT-UHFFFAOYSA-N alphachloralose Chemical compound O1C(C(Cl)(Cl)Cl)OC2C(O)C(C(O)CO)OC21 OJYGBLRPYBAHRT-UHFFFAOYSA-N 0.000 description 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical compound [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 230000003024 amidolytic effect Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 239000000729 antidote Substances 0.000 description 1
- 239000004019 antithrombin Substances 0.000 description 1
- XMQFTWRPUQYINF-UHFFFAOYSA-N bensulfuron-methyl Chemical compound COC(=O)C1=CC=CC=C1CS(=O)(=O)NC(=O)NC1=NC(OC)=CC(OC)=N1 XMQFTWRPUQYINF-UHFFFAOYSA-N 0.000 description 1
- 230000008436 biogenesis Effects 0.000 description 1
- 230000008033 biological extinction Effects 0.000 description 1
- 210000001772 blood platelet Anatomy 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 229940105772 coagulation factor vii Drugs 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000003795 desorption Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000012538 diafiltration buffer Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002270 exclusion chromatography Methods 0.000 description 1
- 201000007219 factor XI deficiency Diseases 0.000 description 1
- XUFQPHANEAPEMJ-UHFFFAOYSA-N famotidine Chemical compound NC(N)=NC1=NC(CSCCC(N)=NS(N)(=O)=O)=CS1 XUFQPHANEAPEMJ-UHFFFAOYSA-N 0.000 description 1
- 239000010200 folin Substances 0.000 description 1
- 238000005194 fractionation Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 108700032141 ganirelix Proteins 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229930195712 glutamate Natural products 0.000 description 1
- 239000011544 gradient gel Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 238000004191 hydrophobic interaction chromatography Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 230000000951 immunodiffusion Effects 0.000 description 1
- 239000012678 infectious agent Substances 0.000 description 1
- 239000003978 infusion fluid Substances 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 230000005976 liver dysfunction Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 201000000050 myeloid neoplasm Diseases 0.000 description 1
- 238000001728 nano-filtration Methods 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 238000005375 photometry Methods 0.000 description 1
- 238000000053 physical method Methods 0.000 description 1
- 238000001470 plasma protein fractionation Methods 0.000 description 1
- 229920002492 poly(sulfone) Polymers 0.000 description 1
- 238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- ZNNZYHKDIALBAK-UHFFFAOYSA-M potassium thiocyanate Chemical compound [K+].[S-]C#N ZNNZYHKDIALBAK-UHFFFAOYSA-M 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 108010026668 snake venom protein C activator Proteins 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229960000999 sodium citrate dihydrate Drugs 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 239000011800 void material Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4833—Thrombin (3.4.21.5)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ATA1591/97 | 1997-09-19 | ||
| AT0159197A AT409334B (de) | 1997-09-19 | 1997-09-19 | Pharmazeutisches präparat enthaltend vitamin k-abhängige einzelfaktoren |
| PCT/AT1998/000224 WO1999015196A1 (de) | 1997-09-19 | 1998-09-17 | Pharmazeutisches präparat enthaltend vitamin k-abhängige einzelfaktoren |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2304396A1 true CA2304396A1 (en) | 1999-04-01 |
Family
ID=3516739
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002304396A Abandoned CA2304396A1 (en) | 1997-09-19 | 1998-09-17 | A pharmaceutical preparation comprising vitamin k-dependent single factors |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1015020A1 (no) |
| JP (1) | JP2001517636A (no) |
| AT (1) | AT409334B (no) |
| AU (1) | AU743102B2 (no) |
| BR (1) | BR9812222A (no) |
| CA (1) | CA2304396A1 (no) |
| HU (1) | HUP0003681A1 (no) |
| NO (1) | NO20001415L (no) |
| SK (1) | SK4022000A3 (no) |
| WO (1) | WO1999015196A1 (no) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7790852B2 (en) | 2003-06-25 | 2010-09-07 | Novo Nordisk Health Care A/G | Liquid composition of factor VII polypeptides |
| US7897734B2 (en) | 2003-03-26 | 2011-03-01 | Novo Nordisk Healthcare Ag | Method for the production of proteins |
| US8022031B2 (en) | 2001-12-21 | 2011-09-20 | Novo Nordisk Health Care A/G | Liquid composition of factor VII polypeptides |
| US8026214B2 (en) | 2003-08-14 | 2011-09-27 | Novo Nordisk Health Care Ag | Liquid, aqueous pharmaceutical compositions of factor VII polypeptides |
| US8299029B2 (en) | 2002-06-21 | 2012-10-30 | Novo Nordisk Health Care Ag | Stabilised solid compositions of factor VII polypeptides |
| US8536127B2 (en) | 2003-05-23 | 2013-09-17 | Novo Nordisk Healthcare Ag | Protein stabilization in solution |
| US8658597B2 (en) | 2003-12-19 | 2014-02-25 | Novo Nordisk Healthcare Ag | Stabilised compositions of factor VII polypeptides |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003075834A2 (en) * | 2002-03-08 | 2003-09-18 | Eli Lilly And Company | Activated protein c formulations |
| CN101151533A (zh) * | 2005-02-16 | 2008-03-26 | 伊利诺斯大学理事会 | 基于金属螯合脂质的促凝血剂 |
| JP2008531692A (ja) | 2005-03-04 | 2008-08-14 | ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・イリノイ | 凝固及び線維素溶解カスケードのモジュレーター |
| US8821861B2 (en) | 2007-10-05 | 2014-09-02 | The Board Of Trustees Of The University Of Illinois | Fibrin sealant |
| US20100297257A1 (en) | 2007-11-09 | 2010-11-25 | National Institutes Of Health (Nih), U.S. Dept. Of Health And Human Services (Dhhs) | Anticoagulant antagonist and hemophillia procoagulant |
| CN103221061A (zh) * | 2010-10-06 | 2013-07-24 | 米迪缪尼有限公司 | 用于治疗止血障碍的因子ii以及纤维蛋白原 |
| CA3046406C (en) * | 2017-02-09 | 2024-01-30 | Csl Behring Gmbh | A blood coagulation factor replacement product for use in the treatment or prophylaxis of bleedings |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8729822D0 (en) * | 1987-12-22 | 1988-02-03 | Central Blood Lab Authority | Chemical process |
| IT1262899B (it) * | 1992-03-27 | 1996-07-22 | Sclavo Spa | Processo per l'isolamento di fattore ix, fattore x e fattore ii altamente purificati dal complesso protrombinico o dal plasma umano |
| DE4342132C1 (de) * | 1993-12-10 | 1994-11-03 | Octapharma Ag | Verfahren zur Herstellung virusinaktivierte Vitamin K abhängige Plasmakomponenten sowie Protein C und Protein S enthaltender Mittel durch Membran-Chromatographie |
| DE4430205A1 (de) * | 1994-08-26 | 1996-02-29 | Behringwerke Ag | Zusammensetzungen, die als Gegenmittel für Blut-Antikoagulanzien geeignet sind und deren Verwendung |
| DE59712322D1 (de) * | 1996-03-20 | 2005-06-30 | Baxter Ag | Pharmazeutisches Präparat zur Behandlung von Blutgerinnungsstörungen |
-
1997
- 1997-09-19 AT AT0159197A patent/AT409334B/de not_active IP Right Cessation
-
1998
- 1998-09-17 AU AU92449/98A patent/AU743102B2/en not_active Ceased
- 1998-09-17 WO PCT/AT1998/000224 patent/WO1999015196A1/de not_active Application Discontinuation
- 1998-09-17 SK SK402-2000A patent/SK4022000A3/sk unknown
- 1998-09-17 JP JP2000512565A patent/JP2001517636A/ja active Pending
- 1998-09-17 EP EP98944886A patent/EP1015020A1/de not_active Withdrawn
- 1998-09-17 HU HU0003681A patent/HUP0003681A1/hu unknown
- 1998-09-17 BR BR9812222-3A patent/BR9812222A/pt not_active Application Discontinuation
- 1998-09-17 CA CA002304396A patent/CA2304396A1/en not_active Abandoned
-
2000
- 2000-03-17 NO NO20001415A patent/NO20001415L/no not_active Application Discontinuation
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8022031B2 (en) | 2001-12-21 | 2011-09-20 | Novo Nordisk Health Care A/G | Liquid composition of factor VII polypeptides |
| US8461116B2 (en) | 2001-12-21 | 2013-06-11 | Novo Nordisk Healthcare Ag | Liquid composition of factor VII polypeptides |
| US8729022B2 (en) | 2002-06-21 | 2014-05-20 | Novo Nordisk Healthcare Ag | Stabilised solid compositions of factor VII polypeptides |
| US8299029B2 (en) | 2002-06-21 | 2012-10-30 | Novo Nordisk Health Care Ag | Stabilised solid compositions of factor VII polypeptides |
| US7897734B2 (en) | 2003-03-26 | 2011-03-01 | Novo Nordisk Healthcare Ag | Method for the production of proteins |
| US8084587B2 (en) | 2003-03-26 | 2011-12-27 | Novo Nordisk Health Care Ag | Method for the production of proteins |
| US8921530B2 (en) | 2003-03-26 | 2014-12-30 | Novo Nordisk Healthcare Ag | Method for the production of proteins |
| US8530630B2 (en) | 2003-03-26 | 2013-09-10 | Novo Nordisk Healthcare A/G | Method for the production of proteins |
| US8536127B2 (en) | 2003-05-23 | 2013-09-17 | Novo Nordisk Healthcare Ag | Protein stabilization in solution |
| US7790852B2 (en) | 2003-06-25 | 2010-09-07 | Novo Nordisk Health Care A/G | Liquid composition of factor VII polypeptides |
| US8026214B2 (en) | 2003-08-14 | 2011-09-27 | Novo Nordisk Health Care Ag | Liquid, aqueous pharmaceutical compositions of factor VII polypeptides |
| US8318904B2 (en) | 2003-08-14 | 2012-11-27 | Novo Nordisk Health Care Ag | Liquid, aqueous pharmaceutical compositions of factor VII polypeptides |
| US8658597B2 (en) | 2003-12-19 | 2014-02-25 | Novo Nordisk Healthcare Ag | Stabilised compositions of factor VII polypeptides |
Also Published As
| Publication number | Publication date |
|---|---|
| BR9812222A (pt) | 2000-07-18 |
| HUP0003681A1 (hu) | 2001-02-28 |
| EP1015020A1 (de) | 2000-07-05 |
| AU9244998A (en) | 1999-04-12 |
| AU743102B2 (en) | 2002-01-17 |
| SK4022000A3 (en) | 2000-09-12 |
| NO20001415D0 (no) | 2000-03-17 |
| AT409334B (de) | 2002-07-25 |
| ATA159197A (de) | 2001-12-15 |
| JP2001517636A (ja) | 2001-10-09 |
| WO1999015196A1 (de) | 1999-04-01 |
| NO20001415L (no) | 2000-05-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |