CA2296765A1 - Proteines de la toxine recombinante soluble du botulinum - Google Patents

Proteines de la toxine recombinante soluble du botulinum Download PDF

Info

Publication number
CA2296765A1
CA2296765A1 CA002296765A CA2296765A CA2296765A1 CA 2296765 A1 CA2296765 A1 CA 2296765A1 CA 002296765 A CA002296765 A CA 002296765A CA 2296765 A CA2296765 A CA 2296765A CA 2296765 A1 CA2296765 A1 CA 2296765A1
Authority
CA
Canada
Prior art keywords
toxin
protein
recombinant
antibody
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002296765A
Other languages
English (en)
Inventor
James A. Williams
Bruce S. Thalley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allergan Inc
Allergan Botox Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/704,159 external-priority patent/US6967088B1/en
Application filed by Individual filed Critical Individual
Publication of CA2296765A1 publication Critical patent/CA2296765A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/02Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from eggs
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1282Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Clostridium (G)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA002296765A 1996-08-28 1997-08-28 Proteines de la toxine recombinante soluble du botulinum Abandoned CA2296765A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/704,159 1996-08-28
US08/704,159 US6967088B1 (en) 1995-03-16 1996-08-28 Soluble recombinant botulinum toxin proteins
PCT/US1997/015394 WO1998008540A1 (fr) 1996-08-28 1997-08-28 VACCIN POLYVALENT CONTRE LA NEUROTOXINE DU $i(CLOSTRIDIUM BOTILINUM)

Publications (1)

Publication Number Publication Date
CA2296765A1 true CA2296765A1 (fr) 1998-03-05

Family

ID=24828333

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002296765A Abandoned CA2296765A1 (fr) 1996-08-28 1997-08-28 Proteines de la toxine recombinante soluble du botulinum

Country Status (4)

Country Link
EP (1) EP1105153A4 (fr)
AU (1) AU4245097A (fr)
CA (1) CA2296765A1 (fr)
WO (1) WO1998008540A1 (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7214787B1 (en) * 1993-09-21 2007-05-08 United States Of America As Represented By The Secretary Of The Army Recombinant vaccine against botulinum neurotoxin
GB9617671D0 (en) 1996-08-23 1996-10-02 Microbiological Res Authority Recombinant toxin fragments
US7192596B2 (en) 1996-08-23 2007-03-20 The Health Protection Agency Ipsen Limited Recombinant toxin fragments
US8012491B2 (en) 1996-08-23 2011-09-06 Syntaxin, Ltd. Recombinant toxin fragments
GB9721189D0 (en) 1997-10-08 1997-12-03 Speywood Lab The Limited Analgesic conjugates
US6495143B2 (en) 1998-07-10 2002-12-17 The United States Of America As Represented By The Secretary Of The Army Botulinum neurotoxin vaccine
AU4641299A (en) * 1998-07-22 2000-02-14 Agricultural Research Council Vaccine comprising a non-toxic immunogenic derivative of (clostridium botulinum)type d neurotoxin
GB9818548D0 (en) 1998-08-25 1998-10-21 Microbiological Res Authority Treatment of mucas hypersecretion
US20040071736A1 (en) 1998-08-25 2004-04-15 Health Protection Agency Methods and compounds for the treatment of mucus hypersecretion
GB9907429D0 (en) 1999-03-31 1999-05-26 Microbiological Res Authority Modulation of C-fibre activity
US7740868B2 (en) 1999-08-25 2010-06-22 Allergan, Inc. Activatable clostridial toxins
WO2001014570A1 (fr) 1999-08-25 2001-03-01 Allergan Sales, Inc. Neurotoxines de recombinaison activables
US20080038274A1 (en) 1999-09-23 2008-02-14 Foster Keith A Inhibition of secretion from non-neuronal cells
US7691983B2 (en) 2000-07-21 2010-04-06 Allergan, Inc. Chimera botulinum toxin type E
ATE371669T1 (de) * 2000-11-06 2007-09-15 Us Army Med Res Mat Command Rekombinante leichte kette des botolinum neurotoxins and fusionsproteine davon zur verwendung in forschung und klinischer therapie
JP3995541B2 (ja) * 2002-06-28 2007-10-24 株式会社ゲン・コーポレーション 抗鶏コクシジウム症組成物
US20050042775A1 (en) * 2003-08-21 2005-02-24 Nicholas Pomato Botulinum antitoxin compositions and methods
GB2456549A (en) * 2008-01-18 2009-07-22 Health Prot Agency Modified botulinum neurotoxin serotype E (BoNT/E) peptides
WO2009152452A1 (fr) * 2008-06-12 2009-12-17 Huei-Hsiung Yang Procédé de fermentation pour la production de protéines neurotoxines botuliques solubles
ES2704069T3 (es) 2011-12-08 2019-03-14 Glaxosmithkline Biologicals Sa Vacuna basada en toxinas de Clostridium difficile
BR112014029585A2 (pt) 2012-05-30 2017-07-25 Harvard College neurotoxina botulínica engendrada
CN115925835A (zh) 2015-03-26 2023-04-07 哈佛大学校长及研究员协会 工程改造的肉毒杆菌神经毒素
JP6910961B2 (ja) * 2015-05-15 2021-07-28 ヌーテック ベンチャーズ 選択細胞への分子送達に適用する遺伝子操作したボツリヌス菌毒素
WO2018039506A1 (fr) 2016-08-24 2018-03-01 President And Fellows Of Harvard College Neurotoxine botulique manipulée

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996005222A1 (fr) * 1994-08-08 1996-02-22 Wisconsin Alumni Research Foundation Procede de purification et compositions pharmaceutiques contenant la neurotoxine botulinique de type g
AU709586B2 (en) * 1994-10-24 1999-09-02 Ophidian Pharmaceuticals, Inc. Vaccine and antitoxin for treatment and prevention of C. difficile disease

Also Published As

Publication number Publication date
WO1998008540A1 (fr) 1998-03-05
EP1105153A4 (fr) 2005-01-19
EP1105153A1 (fr) 2001-06-13
AU4245097A (en) 1998-03-19

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Date Code Title Description
EEER Examination request
FZDE Discontinued