CA2291721C - Ribosome complexes as selection particles for in vitro display and evolution of proteins - Google Patents
Ribosome complexes as selection particles for in vitro display and evolution of proteins Download PDFInfo
- Publication number
- CA2291721C CA2291721C CA2291721A CA2291721A CA2291721C CA 2291721 C CA2291721 C CA 2291721C CA 2291721 A CA2291721 A CA 2291721A CA 2291721 A CA2291721 A CA 2291721A CA 2291721 C CA2291721 C CA 2291721C
- Authority
- CA
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- Prior art keywords
- mrna
- protein
- peptide
- complexed
- dna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1041—Ribosome/Polysome display, e.g. SPERT, ARM
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9710829.4A GB9710829D0 (en) | 1997-05-28 | 1997-05-28 | Selection particles for in vitro display and evolution of antibody combining sites |
| GB9710829.4 | 1997-05-28 | ||
| GB9724850.4 | 1997-11-26 | ||
| GBGB9724850.4A GB9724850D0 (en) | 1997-11-26 | 1997-11-26 | Selection particles for in vitro display and evolution of antibody combining sites |
| GB9804195.7 | 1998-02-28 | ||
| GBGB9804195.7A GB9804195D0 (en) | 1998-02-28 | 1998-02-28 | Selection particles for in vitro display and evolution of antibody combining sites |
| PCT/GB1998/001564 WO1998054312A1 (en) | 1997-05-28 | 1998-05-28 | Ribosome complexes as selection particles for in vitro display and evolution of proteins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2291721A1 CA2291721A1 (en) | 1998-12-03 |
| CA2291721C true CA2291721C (en) | 2011-08-09 |
Family
ID=27268863
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2291721A Expired - Fee Related CA2291721C (en) | 1997-05-28 | 1998-05-28 | Ribosome complexes as selection particles for in vitro display and evolution of proteins |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6620587B1 (enExample) |
| EP (1) | EP0985032B2 (enExample) |
| JP (1) | JP4060892B2 (enExample) |
| AT (1) | ATE250668T1 (enExample) |
| CA (1) | CA2291721C (enExample) |
| DE (1) | DE69818458T3 (enExample) |
| DK (1) | DK0985032T4 (enExample) |
| ES (1) | ES2209145T5 (enExample) |
| PT (1) | PT985032E (enExample) |
| WO (1) | WO1998054312A1 (enExample) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4854999A (en) * | 1998-07-02 | 2000-01-24 | Invitro Diagnostics, Inc. | Methods, compositions and apparatus for making nucleic acid molecules having a selected affinity to a target molecule |
| DE19932688B4 (de) | 1999-07-13 | 2009-10-08 | Scil Proteins Gmbh | Design von Beta-Faltblatt-Proteinen des gamma-II-kristallins antikörperähnlichen |
| GB9917027D0 (en) * | 1999-07-20 | 1999-09-22 | Affibody Technology Sweeden Ab | In vitro selection and optional identification of polypeptides using solid support carriers |
| EP1276900A2 (en) | 2000-01-11 | 2003-01-22 | Maxygen, Inc. | Integrated systems and methods for diversity generation and screening |
| CA2402452A1 (en) | 2000-03-31 | 2001-10-11 | Cambridge Antibody Technology Limited | Improvements to ribosome display |
| EP1652919A1 (en) * | 2000-03-31 | 2006-05-03 | Cambridge Antibody Technology LTD | Improvements to ribosome display |
| US7129326B2 (en) | 2000-04-14 | 2006-10-31 | Genencor International, Inc. | Methods for selective targeting |
| US20020098524A1 (en) | 2000-04-14 | 2002-07-25 | Murray Christopher J. | Methods for selective targeting |
| EP1372721A4 (en) | 2001-03-07 | 2008-04-02 | Childrens Medical Center | METHOD FOR SCREENING PEPTIDE DISPLAY LIBRARIES WITH A MINIMUM DISPLAY |
| EP1401850A1 (en) * | 2001-06-20 | 2004-03-31 | Nuevolution A/S | Nucleoside derivatives for library preparation |
| US20060234231A1 (en) * | 2001-06-20 | 2006-10-19 | Nuevolution A/S | Microarrays displaying encoded molecules |
| DE10145226A1 (de) * | 2001-09-13 | 2003-04-10 | Lifebits Ag | Herstellung von trägergebundenen Molekülen |
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| JPH06178688A (ja) | 1992-12-11 | 1994-06-28 | Mitsui Toatsu Chem Inc | Ｅ型緑膿菌を抗原とするヒト抗体をコードする遺伝子 |
| AU8124694A (en) * | 1993-10-29 | 1995-05-22 | Affymax Technologies N.V. | In vitro peptide and antibody display libraries |
| CA2402452A1 (en) | 2000-03-31 | 2001-10-11 | Cambridge Antibody Technology Limited | Improvements to ribosome display |
-
1998
- 1998-05-28 ES ES98924468T patent/ES2209145T5/es not_active Expired - Lifetime
- 1998-05-28 US US09/424,712 patent/US6620587B1/en not_active Expired - Lifetime
- 1998-05-28 DK DK98924468T patent/DK0985032T4/da active
- 1998-05-28 CA CA2291721A patent/CA2291721C/en not_active Expired - Fee Related
- 1998-05-28 EP EP98924468A patent/EP0985032B2/en not_active Expired - Lifetime
- 1998-05-28 PT PT98924468T patent/PT985032E/pt unknown
- 1998-05-28 DE DE69818458T patent/DE69818458T3/de not_active Expired - Lifetime
- 1998-05-28 AT AT98924468T patent/ATE250668T1/de active
- 1998-05-28 WO PCT/GB1998/001564 patent/WO1998054312A1/en not_active Ceased
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| CA2291721A1 (en) | 1998-12-03 |
| AU7666698A (en) | 1998-12-30 |
| JP2002500514A (ja) | 2002-01-08 |
| PT985032E (pt) | 2004-02-27 |
| AU725957B2 (en) | 2000-10-26 |
| DK0985032T3 (da) | 2004-02-02 |
| JP4060892B2 (ja) | 2008-03-12 |
| DE69818458T2 (de) | 2004-07-08 |
| DK0985032T4 (da) | 2009-08-31 |
| DE69818458D1 (de) | 2003-10-30 |
| EP0985032B1 (en) | 2003-09-24 |
| WO1998054312A1 (en) | 1998-12-03 |
| US6620587B1 (en) | 2003-09-16 |
| EP0985032A1 (en) | 2000-03-15 |
| ES2209145T5 (es) | 2009-10-30 |
| ES2209145T3 (es) | 2004-06-16 |
| EP0985032B2 (en) | 2009-06-03 |
| ATE250668T1 (de) | 2003-10-15 |
| DE69818458T3 (de) | 2009-12-17 |
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