CA2284795C - Novel pyrimidine derivatives and processes for the preparation thereof - Google Patents

Novel pyrimidine derivatives and processes for the preparation thereof Download PDF

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Publication number
CA2284795C
CA2284795C CA002284795A CA2284795A CA2284795C CA 2284795 C CA2284795 C CA 2284795C CA 002284795 A CA002284795 A CA 002284795A CA 2284795 A CA2284795 A CA 2284795A CA 2284795 C CA2284795 C CA 2284795C
Authority
CA
Canada
Prior art keywords
methyl
pyrimidine
fluorophenylamino
dimethyl
tetrahydroisoquinolin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002284795A
Other languages
English (en)
French (fr)
Other versions
CA2284795A1 (en
Inventor
Jong Wook Lee
Bong Yong Lee
Chang Seop Kim
Seung Kyu Lee
Keun Seog Song
Song Jin Lee
Woo Jeon Shim
Man Soon Hwang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yuhan Corp
Original Assignee
Yuhan Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yuhan Corp filed Critical Yuhan Corp
Publication of CA2284795A1 publication Critical patent/CA2284795A1/en
Application granted granted Critical
Publication of CA2284795C publication Critical patent/CA2284795C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA002284795A 1997-03-27 1998-03-24 Novel pyrimidine derivatives and processes for the preparation thereof Expired - Fee Related CA2284795C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
KR1997/10863 1997-03-27
KR1997/10862 1997-03-27
KR19970010862 1997-03-27
KR19970010863 1997-03-27
PCT/KR1998/000058 WO1998043968A1 (en) 1997-03-27 1998-03-24 Novel pyrimidine derivatives and processes for the preparation thereof

Publications (2)

Publication Number Publication Date
CA2284795A1 CA2284795A1 (en) 1998-10-08
CA2284795C true CA2284795C (en) 2004-01-20

Family

ID=26632616

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002284795A Expired - Fee Related CA2284795C (en) 1997-03-27 1998-03-24 Novel pyrimidine derivatives and processes for the preparation thereof

Country Status (21)

Country Link
US (1) US6352993B1 (2)
EP (1) EP1015444B1 (2)
JP (1) JP3176379B2 (2)
KR (1) KR100278857B1 (2)
CN (1) CN1118464C (2)
AR (1) AR012181A1 (2)
AT (1) ATE241613T1 (2)
AU (1) AU720385B2 (2)
BR (1) BR9808070A (2)
CA (1) CA2284795C (2)
DE (1) DE69815126T2 (2)
DK (1) DK1015444T3 (2)
ES (1) ES2200324T3 (2)
HU (1) HUP0000851A3 (2)
IN (1) IN188411B (2)
PT (1) PT1015444E (2)
RU (1) RU2203894C2 (2)
TR (1) TR199902383T2 (2)
TW (1) TW542831B (2)
UY (1) UY24938A1 (2)
WO (1) WO1998043968A1 (2)

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KR100272471B1 (ko) 1998-11-17 2000-11-15 김선진 신규의 피리미딘 유도체 및 그의 제조방법
US6852739B1 (en) 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
TW200302728A (en) 2002-02-01 2003-08-16 Novartis Ag Substituted amines as IgE inhibitors
US7211590B2 (en) 2002-08-01 2007-05-01 Nitromed, Inc. Nitrosated proton pump inhibitors, compositions and methods of use
CN1826328A (zh) * 2003-07-22 2006-08-30 神经能质公司 经取代的吡啶－2－基胺类似物
AU2004283751B2 (en) * 2003-10-24 2011-05-19 Exelixis, Inc. p70S6 kinase modulators and method of use
AU2004285394B2 (en) 2003-11-03 2009-01-08 Astrazeneca Ab Imidazo (1,2-A) pyridine derivatives for the treatment of silent gastro-esophageal reflux
KR101122376B1 (ko) * 2005-03-09 2012-03-26 주식회사유한양행 신규의 5,6-다이메틸피리미딘 유도체 및 그의 제조방법
JP2009511548A (ja) * 2005-10-14 2009-03-19 ノイロサーチ アクティーゼルスカブ 新規ピリミジン−２，４−ジアミン誘導体及び小コンダクタンスのカルシウム依存性カリウムチャネルのモジュレーターとしてのこれらの使用
JP4946482B2 (ja) 2007-02-08 2012-06-06 船井電機株式会社 緩衝用梱包材及びｔｖ受像機の緩衝用梱包材
US8367684B2 (en) * 2007-06-13 2013-02-05 Valeant Pharmaceuticals International Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators
EP2308877B1 (en) 2008-08-05 2014-01-22 Daiichi Sankyo Company, Limited Imidazopyridin-2-one derivatives
GB0908394D0 (en) 2009-05-15 2009-06-24 Univ Leuven Kath Novel viral replication inhibitors
GB0913636D0 (en) 2009-08-05 2009-09-16 Univ Leuven Kath Novel viral replication inhibitors
MX2013005478A (es) 2010-11-15 2013-08-29 Univ Leuven Kath Compuestos heterociclicos condensados antivirales.
HUE029988T2 (en) * 2011-02-25 2017-04-28 Yuhan Corp Diaminopyrimidine derivatives and processes for their preparation
EP2836486B1 (en) * 2012-02-17 2017-10-04 AbbVie Inc. Diaminopyrimidines useful as inhibitors of the human respiratory syncytial virus (rsv)
KR102080782B1 (ko) 2012-05-29 2020-02-27 모멘티브 퍼포먼스 머티리얼즈 게엠베하 이소시아네이토 실란의 제조
CA2892045C (en) 2012-11-21 2022-05-31 Ptc Therapeutics, Inc. Substituted reverse pyrimidine bmi-1 inhibitors
BR112015022545A2 (pt) 2013-03-13 2017-07-18 Constellation Pharmaceuticals Inc compostos de pirazolo e os usos disso
AU2013399092A1 (en) 2013-08-30 2016-03-17 Ptc Therapeutics, Inc. Substituted pyrimidine Bmi-1 inhibitors
ES2779152T3 (es) * 2013-10-07 2020-08-13 Kadmon Corporation Llc Derivados de (2-(5-isoindolin-2-il)pirimidin-4-il)-amina como inhibidores de Rho-quinasa para tratar enfermedades autoinmunes
EP3071553A4 (en) 2013-11-21 2017-08-02 PTC Therapeutics, Inc. Substituted pyridine and pyrazine bmi-1 inhibitors
AU2015335980A1 (en) * 2014-10-22 2017-05-18 Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences Small-molecule inhibitors targeting discoidin domain receptor 1 and uses thereof
CN105669642B (zh) * 2014-11-19 2020-06-09 江苏天士力帝益药业有限公司 一种盐酸洛氟普啶的制备方法
SMT202200248T1 (it) * 2016-01-04 2022-07-21 ObsEva SA Cosomministrazione di alfa-ammino estere di derivato di idrossipropiltiazolidina carbossammide e un agente tocolitico
US11477982B2 (en) * 2017-04-05 2022-10-25 Bayer Cropscience Aktiengesellschaft 2-amino-5-oxyalkyl-pyrimidine derivatives and their use for controlling undesired plant growth
WO2020055544A2 (en) 2018-08-17 2020-03-19 Ptc Therapeutics, Inc. Method for treating pancreatic cancer
CN114685369B (zh) * 2022-05-17 2024-02-02 河南省科学院高新技术研究中心 一种利用离子液体制备1-甲基-1,2,3,4-四氢异喹啉的方法

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US3980781A (en) 1966-03-31 1976-09-14 Imperial Chemical Industries Limited Fungicidal composition and method containing 2-amino-pyrimidines
US4000138A (en) 1966-03-31 1976-12-28 Imperial Chemical Industries Limited Organic compounds and compositions containing them
GB1182584A (en) 1966-03-31 1970-02-25 Ici Ltd Pyrimidine derivates and the use thereof as fungicides
US4044136A (en) 1972-09-09 1977-08-23 Pfizer Inc. Aminoquinazoline therapeutic agents
GB1383409A (en) 1972-09-09 1974-02-12 Pfizer Ltd Derivatives of 2-amino- and 4-amino-quinazoline and pharmaceutical compositions containing them
US3956495A (en) 1973-10-30 1976-05-11 Eli Lilly And Company 2,4-Diaminoquinazolines as antithrombotic agents
US4755218A (en) 1985-12-31 1988-07-05 Monsanto Company Haloacyl 1-substituted-1,2,3,4-tetrahydro-isoquinolines as herbicide antidotes
GB8621425D0 (en) * 1986-09-05 1986-10-15 Smith Kline French Lab Compounds
IL88507A (en) * 1987-12-03 1993-02-21 Smithkline Beckman Intercredit 2,4-diaminoquinazolines, process for their preparation and pharmaceutical compositions comprising them
US4966622A (en) 1988-04-12 1990-10-30 Ciba-Geigy Corporation N-phenyl-N-pyrimidin-2-ylureas
HU206337B (en) * 1988-12-29 1992-10-28 Mitsui Petrochemical Ind Process for producing pyrimidine derivatives and pharmaceutical compositions
DE3901448A1 (de) 1989-01-19 1990-07-26 Basf Ag Emulsionscopolymerisate
ES2081863T3 (es) 1989-03-22 1996-03-16 Ciba Geigy Ag Plaguicidas.
GB8910722D0 (en) 1989-05-10 1989-06-28 Smithkline Beckman Intercredit Compounds
CA2015981A1 (en) * 1989-05-10 1990-11-10 Thomas H. Brown Compounds
GB9012592D0 (en) 1990-06-06 1990-07-25 Smithkline Beecham Intercredit Compounds
JPH05507290A (ja) 1990-11-06 1993-10-21 フアイザー・インコーポレイテツド 抗腫瘍活性を強化するためのキナゾリン誘導体
BR9205906A (pt) 1991-04-17 1994-07-05 Pfizer Derivados de pirimidina para aumento da atividade antitumoral
US5276186A (en) 1992-03-11 1994-01-04 Ciba-Geigy Corporation Process for the production of guanidine derivatives
KR0144833B1 (ko) * 1992-12-28 1998-07-15 김태훈 신규의 퀴나졸린 유도체 및 그의 제조방법
HUT75876A (en) * 1993-08-12 1997-05-28 Astra Ab Amidine derivatives with nitric oxide synthetase activities, pharmaceutical compositions containing them and process for their preparation
DE69408750T2 (de) 1993-08-26 1998-07-23 Ono Pharmaceutical Co 4-Aminopyrimidin Derivate
WO1995010506A1 (en) 1993-10-12 1995-04-20 The Du Pont Merck Pharmaceutical Company 1n-alkyl-n-arylpyrimidinamines and derivatives thereof
JP2896532B2 (ja) * 1994-08-13 1999-05-31 ユーハン コーポレーション 新規なピリミジン誘導体およびその製造方法
AU712970B2 (en) * 1996-05-04 1999-11-18 Yuhan Corporation Process for preparation of pyrimidine derivatives

Also Published As

Publication number Publication date
CA2284795A1 (en) 1998-10-08
WO1998043968A1 (en) 1998-10-08
DE69815126D1 (de) 2003-07-03
HK1026418A1 (en) 2000-12-15
UY24938A1 (es) 2001-01-31
DE69815126T2 (de) 2004-04-08
KR19980080789A (ko) 1998-11-25
US6352993B1 (en) 2002-03-05
IN188411B (2) 2002-09-21
EP1015444B1 (en) 2003-05-28
KR100278857B1 (ko) 2001-01-15
RU2203894C2 (ru) 2003-05-10
HUP0000851A1 (hu) 2001-04-28
HUP0000851A3 (en) 2002-04-29
AR012181A1 (es) 2000-09-27
TR199902383T2 (xx) 2000-06-21
CN1251586A (zh) 2000-04-26
AU6523998A (en) 1998-10-22
TW542831B (en) 2003-07-21
PT1015444E (pt) 2003-10-31
EP1015444A1 (en) 2000-07-05
DK1015444T3 (da) 2003-08-18
ES2200324T3 (es) 2004-03-01
BR9808070A (pt) 2000-03-08
AU720385B2 (en) 2000-06-01
JP2000513014A (ja) 2000-10-03
CN1118464C (zh) 2003-08-20
JP3176379B2 (ja) 2001-06-18
ATE241613T1 (de) 2003-06-15

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