CA2283199C - Inhalation device - Google Patents

Inhalation device Download PDF

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Publication number
CA2283199C
CA2283199C CA002283199A CA2283199A CA2283199C CA 2283199 C CA2283199 C CA 2283199C CA 002283199 A CA002283199 A CA 002283199A CA 2283199 A CA2283199 A CA 2283199A CA 2283199 C CA2283199 C CA 2283199C
Authority
CA
Canada
Prior art keywords
inhaler according
mouthpiece
inhaler
chamber
disc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002283199A
Other languages
English (en)
French (fr)
Other versions
CA2283199A1 (en
Inventor
Jan Andersson
Allan Dagsland
Kjell Wetterlin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Astra AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra AB filed Critical Astra AB
Publication of CA2283199A1 publication Critical patent/CA2283199A1/en
Application granted granted Critical
Publication of CA2283199C publication Critical patent/CA2283199C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A61M11/002—Particle size control by flow deviation causing inertial separation of transported particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0005—Details of inhalators; Constructional features thereof with means for agitating the medicament
    • A61M15/0006—Details of inhalators; Constructional features thereof with means for agitating the medicament using rotating means
    • A61M15/0008—Details of inhalators; Constructional features thereof with means for agitating the medicament using rotating means rotating by airflow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0001—Details of inhalators; Constructional features thereof
    • A61M15/0021—Mouthpieces therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
    • A61M15/007—Mechanical counters
    • A61M15/0071—Mechanical counters having a display or indicator
    • A61M15/0076—Mechanical counters having a display or indicator on a drum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0086—Inhalation chambers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2206/00—Characteristics of a physical parameter; associated device therefor
    • A61M2206/10—Flow characteristics
    • A61M2206/16—Rotating swirling helical flow, e.g. by tangential inflows

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Anesthesiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Nozzles (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Manipulator (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
CA002283199A 1997-03-14 1998-03-13 Inhalation device Expired - Fee Related CA2283199C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9700937A SE9700937D0 (sv) 1997-03-14 1997-03-14 Powder inhaler I
SE9700937-7 1997-03-14
PCT/SE1998/000465 WO1998041264A1 (en) 1997-03-14 1998-03-13 Inhalation device

Publications (2)

Publication Number Publication Date
CA2283199A1 CA2283199A1 (en) 1998-09-24
CA2283199C true CA2283199C (en) 2007-05-29

Family

ID=20406164

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002283199A Expired - Fee Related CA2283199C (en) 1997-03-14 1998-03-13 Inhalation device

Country Status (20)

Country Link
US (1) US6257232B1 (enExample)
EP (1) EP0979115B1 (enExample)
JP (2) JP4057066B2 (enExample)
KR (1) KR100466998B1 (enExample)
CN (1) CN100500238C (enExample)
AR (1) AR020247A2 (enExample)
AT (1) ATE233113T1 (enExample)
AU (1) AU6431198A (enExample)
BR (1) BR9808312A (enExample)
CA (1) CA2283199C (enExample)
DE (1) DE69811655T2 (enExample)
DK (1) DK0979115T3 (enExample)
ES (1) ES2191928T3 (enExample)
NO (1) NO322447B1 (enExample)
NZ (1) NZ337479A (enExample)
PL (1) PL188855B1 (enExample)
PT (1) PT979115E (enExample)
SE (1) SE9700937D0 (enExample)
WO (1) WO1998041264A1 (enExample)
ZA (1) ZA982021B (enExample)

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AU761307B2 (en) * 1997-03-14 2003-06-05 Astra Aktiebolag Inhalation device
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
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SI1142601T1 (sl) * 2000-04-07 2006-08-31 Andi Ventis Ltd Ustnik za inhalator
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PE20020067A1 (es) * 2000-06-23 2002-02-05 Norton Healthcare Ltd Desaglomerador para inhalador de polvo seco accionado por la respiracion
DE10040528A1 (de) * 2000-08-18 2002-02-28 Pari Gmbh Inhalationsvorrichtung und Verfahren zur Erzeugung eines Partikelnebels für Inhalationszwecke
US6681768B2 (en) * 2001-06-22 2004-01-27 Sofotec Gmbh & Co. Kg Powder formulation disintegrating system and method for dry powder inhalers
JP3619176B2 (ja) * 2001-09-14 2005-02-09 オムロンヘルスケア株式会社 エアロゾル粒子分別装置及び吸入器
ES2425392T3 (es) 2002-03-20 2013-10-15 Mannkind Corporation Cartucho para un aparato de inhalación
GR1004350B (el) * 2002-03-29 2003-09-26 Συσκευη εισπνοων ξηρης σκονης
DK1786784T3 (da) 2004-08-20 2011-02-14 Mannkind Corp Katalyse af diketopiperazinsyntese
BR122019022692B1 (pt) 2004-08-23 2023-01-10 Mannkind Corporation Composição terapêutica em pó seco contendo dicetopiperazina, pelo menos um tipo de cátion e um agente biologicamente ativo
KR101338969B1 (ko) * 2004-11-10 2013-12-10 씨아이피엘에이 엘티디. 흡입기
WO2007033372A2 (en) 2005-09-14 2007-03-22 Mannkind Corporation Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
EP1965848A4 (en) * 2005-12-23 2012-12-05 Astrazeneca Ab NEW DEVICE
DE102006007495A1 (de) * 2006-02-17 2007-08-23 Siegfried Generics International Ag Dispergiereinheit
DK1986679T3 (da) 2006-02-22 2017-11-20 Mannkind Corp Fremgangsmåde til forbedring af mikropartiklers farmaceutiske egenskaber omfattende diketopiperazin og et aktivt indholdsstof
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KR100638340B1 (ko) * 2006-03-15 2006-10-27 송인호 낙곡 회수용 흡입기
DE102006047667B3 (de) * 2006-09-28 2008-04-24 Ing. Erich Pfeiffer Gmbh Inhalationsvorrichtung
JP2010508069A (ja) 2006-10-25 2010-03-18 ノバルティス アーゲー パウダー分散装置、その装置の製造方法および使用方法、その装置および他の装置に使用される構成要素
US20100139655A1 (en) * 2006-11-19 2010-06-10 Aespironics Ltd Dry-powder inhaler
PE20100117A1 (es) * 2008-05-23 2010-03-03 Otsuka Pharma Co Ltd Inhalador de polvo
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
CA3153292A1 (en) 2008-06-13 2009-12-17 Mannkind Corporation A dry powder inhaler and system for drug delivery
CN102065942B (zh) 2008-06-20 2013-12-11 曼金德公司 用于对吸入工作进行实时描绘的交互式设备和方法
TWI532497B (zh) 2008-08-11 2016-05-11 曼凱公司 超快起作用胰島素之用途
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
PL2405963T3 (pl) 2009-03-11 2014-04-30 Mannkind Corp Urządzenie, układ i sposób pomiaru oporu inhalatora
KR20180036807A (ko) 2009-06-12 2018-04-09 맨카인드 코포레이션 한정된 비표면적을 갖는 디케토피페라진 마이크로입자
CA2778698A1 (en) 2009-11-03 2011-05-12 Mannkind Corporation An apparatus and method for simulating inhalation efforts
RU2571331C1 (ru) 2010-06-21 2015-12-20 Маннкайнд Корпорейшн Системы и способы доставки сухих порошковых лекарств
KR101940832B1 (ko) 2011-04-01 2019-01-21 맨카인드 코포레이션 의약 카트리지용 블리스터 패키지
CN102218182B (zh) * 2011-06-13 2015-02-18 上海秀新臣邦医药科技有限公司 一种干粉给药装置的振动给药装置
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
EP2776053A1 (en) 2011-10-24 2014-09-17 MannKind Corporation Methods and compositions for treating pain
CN104619369B (zh) 2012-07-12 2018-01-30 曼金德公司 干粉药物输送系统和方法
EP2911690A1 (en) 2012-10-26 2015-09-02 MannKind Corporation Inhalable influenza vaccine compositions and methods
AU2014228415B2 (en) 2013-03-15 2018-08-09 Mannkind Corporation Microcrystalline diketopiperazine compositions and methods
CA2918369C (en) 2013-07-18 2021-06-29 Mannkind Corporation Heat-stable dry powder pharmaceutical compositions and methods
WO2015021064A1 (en) 2013-08-05 2015-02-12 Mannkind Corporation Insufflation apparatus and methods
EP3057627B1 (en) * 2013-10-15 2018-07-25 Mystic Pharmaceuticals, Inc. Controllable rate turbulating nozzle
GB201401154D0 (en) * 2014-01-23 2014-03-12 Team Holdings Uk Ltd Medical apparatus and method
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
CN104971411B (zh) * 2015-06-30 2023-08-29 上海臣邦医药科技股份有限公司 一种粉雾剂给药装置
CN105031782B (zh) * 2015-06-30 2020-06-26 上海臣邦医药科技股份有限公司 一种提高粉雾剂给药装置加药量计量准确性的方法
CN104971412B (zh) * 2015-06-30 2020-06-26 上海臣邦医药科技股份有限公司 一种粉雾剂给药装置的振动储药单元
CN104971413B (zh) * 2015-06-30 2023-04-14 上海臣邦医药科技股份有限公司 一种粉雾剂给药装置的防误操作单元及防误操作方法
CN104971415B (zh) * 2015-06-30 2020-06-26 上海臣邦医药科技股份有限公司 一种粉雾剂给药装置的双振动储药单元
CN111437473B (zh) * 2020-04-16 2023-03-24 宁波诺丁汉大学 一种粉雾剂吸入装置
US11925749B2 (en) * 2021-03-18 2024-03-12 Funai Electric Co., Ltd. Venting of pharmaceutical drug delivery device for air flow and humidity control
US20220409828A1 (en) * 2021-06-11 2022-12-29 Boa Nutrition, Inc. Nozzle with fan for delivering aerosols
CN115814216A (zh) * 2022-11-22 2023-03-21 东莞市中科智恒新材料有限公司 一种高性能电子雾化器
CN116603139B (zh) * 2023-05-16 2025-10-31 珠海瑞思普利医药科技有限公司 一种可便捷拆装的药粉吸入装置
CN116510140A (zh) * 2023-05-16 2023-08-01 珠海瑞思普利医药科技有限公司 一种药粉吸入装置

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Also Published As

Publication number Publication date
US6257232B1 (en) 2001-07-10
BR9808312A (pt) 2000-05-16
NO994434D0 (no) 1999-09-13
DE69811655T2 (de) 2003-12-18
JP4057066B2 (ja) 2008-03-05
JP2001517984A (ja) 2001-10-09
CN1810312A (zh) 2006-08-02
PL335690A1 (en) 2000-05-08
ES2191928T3 (es) 2003-09-16
JP2007229523A (ja) 2007-09-13
PL188855B1 (pl) 2005-05-31
AR020247A2 (es) 2002-05-02
PT979115E (pt) 2003-07-31
ZA982021B (en) 1999-12-10
KR100466998B1 (ko) 2005-01-24
SE9700937D0 (sv) 1997-03-14
EP0979115A1 (en) 2000-02-16
DK0979115T3 (da) 2003-05-19
AU6431198A (en) 1998-10-12
HK1029291A1 (en) 2001-03-30
CN100500238C (zh) 2009-06-17
CA2283199A1 (en) 1998-09-24
NO322447B1 (no) 2006-10-09
ATE233113T1 (de) 2003-03-15
DE69811655D1 (de) 2003-04-03
NZ337479A (en) 2001-05-25
NO994434L (no) 1999-11-03
KR20000076198A (ko) 2000-12-26
EP0979115B1 (en) 2003-02-26
WO1998041264A1 (en) 1998-09-24

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