CA2254954C - Morphogen treatment for chronic renal failure - Google Patents
Morphogen treatment for chronic renal failure Download PDFInfo
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- CA2254954C CA2254954C CA002254954A CA2254954A CA2254954C CA 2254954 C CA2254954 C CA 2254954C CA 002254954 A CA002254954 A CA 002254954A CA 2254954 A CA2254954 A CA 2254954A CA 2254954 C CA2254954 C CA 2254954C
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6077823A (en) * | 1991-03-11 | 2000-06-20 | Creative Biomolecules, Inc. | Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury |
| CA2363965C (en) * | 1991-03-11 | 2010-05-18 | Curis, Inc. | Protein-induced morphogenesis |
| US20030167492A1 (en) | 1994-07-08 | 2003-09-04 | Johns Hopkins University School Of Medicine | Transgenic non-human animals expressing a gdf-11 dominant negative polypeptide, and methods of making and using same |
| US6498142B1 (en) * | 1996-05-06 | 2002-12-24 | Curis, Inc. | Morphogen treatment for chronic renal failure |
| AU743510B2 (en) | 1997-05-05 | 2002-01-24 | Stryker Corporation | Therapies for acute renal failure |
| WO1998050061A1 (en) * | 1997-05-07 | 1998-11-12 | Biogen, Inc. | Novel therapies for cystic kidney disease |
| EP0896825B1 (en) | 1997-08-14 | 2002-07-17 | Sulzer Innotec Ag | Composition and device for in vivo cartilage repair comprising nanocapsules with osteoinductive and/or chondroinductive factors |
| US6203788B1 (en) * | 1997-09-29 | 2001-03-20 | Adherex Inc. | Compounds and methods for regulating cell adhesion |
| AU1706499A (en) * | 1997-12-04 | 1999-06-16 | Curis, Inc. | Maintenance of smooth muscle integrity by morphogenic proteins |
| JP2002526034A (ja) * | 1998-07-28 | 2002-08-20 | ザ ジョンズ ホプキンス ユニバーシティー スクール オブ メディシン | 増殖分化因子−１１ |
| US7087577B2 (en) * | 1998-10-16 | 2006-08-08 | Zimmer Orthobiologies, Inc. | Method of promoting natural bypass |
| US6992066B2 (en) * | 1998-10-16 | 2006-01-31 | Zimmer Orthobiologics, Inc. | Povidone-containing carriers for polypeptide growth factors |
| NZ517781A (en) * | 1999-09-14 | 2004-01-30 | Biogen Inc | Therapies for chronic renal failure using one or more integrin antagonists |
| US20020173453A1 (en) * | 2000-12-15 | 2002-11-21 | Rama Akella | Method of treating renal injury |
| US7700819B2 (en) | 2001-02-16 | 2010-04-20 | Kci Licensing, Inc. | Biocompatible wound dressing |
| US7763769B2 (en) | 2001-02-16 | 2010-07-27 | Kci Licensing, Inc. | Biocompatible wound dressing |
| US7232802B2 (en) * | 2001-12-21 | 2007-06-19 | Zimmer Orthobiologics, Inc. | Compositions and methods for promoting myocardial and peripheral angiogenesis |
| US7622562B2 (en) | 2002-06-26 | 2009-11-24 | Zimmer Orthobiologics, Inc. | Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue |
| JP2006516020A (ja) * | 2002-08-28 | 2006-06-15 | キュリス インコーポレイテッド | 慢性腎不全の治療におけるモルフォゲン及びａｃｅ阻害薬の共投与 |
| US7576052B2 (en) | 2003-10-17 | 2009-08-18 | Joslin Diabetes Center, Inc. | Methods and compositions for modulating adipocyte function |
| US7844367B2 (en) | 2003-12-23 | 2010-11-30 | Rain Bird Corporation | Code replacement for irrigation controllers |
| AU2005228696B2 (en) | 2004-03-30 | 2010-06-24 | Relypsa, Inc. | Methods and compositions for treatment of ion imbalances |
| JP2008500816A (ja) * | 2004-03-31 | 2008-01-17 | ゼンコー・インコーポレイテッド | 改善された性質を有するｂｍｐ−７変異体 |
| WO2006130690A2 (en) | 2005-06-01 | 2006-12-07 | Joslin Diabetes Center, Inc. | Methods and compositions for inducing brown adipogenesis |
| EP3536704B1 (en) | 2005-11-14 | 2021-08-25 | Boehringer Ingelheim Animal Health USA Inc. | Gene therapy for renal failure |
| US7771995B2 (en) * | 2005-11-14 | 2010-08-10 | Merial Limited | Plasmid encoding human BMP-7 |
| US20090004159A1 (en) * | 2006-01-24 | 2009-01-01 | The Board Of Trustees Of The University Of Illinoi | Polymerized Hemoglobin Media and Its Use in Isolation and Transplantation of Islet Cells |
| WO2007087570A2 (en) | 2006-01-24 | 2007-08-02 | Northfield Laboratories, Inc. | Polymerized hemoglobin media and its use in isolation and transplantation of islet cells |
| US20080090765A1 (en) * | 2006-05-25 | 2008-04-17 | The Trustees Of Columbia University In The City Of New York | Compositions for modulating growth of embryonic and adult kidney tissue and uses for treating kidney damage |
| ES2379603T3 (es) | 2006-05-30 | 2012-04-27 | Antibodyshop A/S | Métodos para la evaluación rápida de la gravedad de un traumatismo |
| US7722665B2 (en) * | 2006-07-07 | 2010-05-25 | Graft Technologies, Inc. | System and method for providing a graft in a vascular environment |
| WO2008010556A1 (fr) * | 2006-07-21 | 2008-01-24 | Chugai Seiyaku Kabushiki Kaisha | Médicament agissant contre une maladie rénale |
| US20080255181A1 (en) * | 2006-12-15 | 2008-10-16 | University Of Heidelberg | Methods for treating podocyte-related disorders |
| WO2008134297A2 (en) * | 2007-04-24 | 2008-11-06 | Johnson & Johnson Regenerative Therapeutics, Llc | Engineered renal tissue |
| DE102007034580B4 (de) * | 2007-07-13 | 2012-11-08 | NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen | Biomaterial basierend auf einem hydrophilen polymeren Träger |
| US20090155245A1 (en) * | 2007-12-18 | 2009-06-18 | Fang Carrie H | Treatment for Organ Regeneration with Combination of Drug and Biologics |
| JP2011523357A (ja) * | 2008-05-06 | 2011-08-11 | ジョスリン ダイアビーティス センター インコーポレイテッド | 褐色脂肪細胞分化を誘導するための方法および組成物 |
| JP5485885B2 (ja) * | 2008-06-24 | 2014-05-07 | 株式会社根本杏林堂 | 薬液注入装置、この薬液注入装置を有する透視撮像システム、薬液注入装置のコンピュータプログラムおよびデータ処理方法 |
| CN105067819B (zh) * | 2008-08-28 | 2018-05-22 | 阿斯图特医药公司 | 用于诊断和预后肾损伤和肾衰竭的方法和组合物 |
| CN105021826A (zh) * | 2008-08-29 | 2015-11-04 | 阿斯图特医药公司 | 用于诊断和预后肾损伤和肾衰竭的方法和组合物 |
| AU2009308497B2 (en) * | 2008-10-21 | 2014-10-23 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| NZ619918A (en) * | 2008-10-21 | 2015-04-24 | Astute Medical Inc | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| KR20110084286A (ko) | 2008-11-10 | 2011-07-21 | 아스튜트 메디컬 인코포레이티드 | 신손상 및 신부전의 진단 및 예후 예측을 위한 방법 및 조성물 |
| CA2743253A1 (en) * | 2008-11-22 | 2010-05-27 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| US9229010B2 (en) | 2009-02-06 | 2016-01-05 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| CN104111336B (zh) * | 2009-02-06 | 2017-01-18 | 阿斯图特医药公司 | 肾损伤和肾衰竭的诊断及预后 |
| AU2010213575B2 (en) * | 2009-02-12 | 2013-11-14 | Stryker Corporation | Peripheral administration of proteins including TGF-beta superfamily members for systemic treatment of disorders and disease |
| EP2396026A2 (en) | 2009-02-12 | 2011-12-21 | Stryker Corporation | Compositions and methods for minimally-invasive systemic delivery of proteins including tgf- superfamily members |
| WO2010103070A2 (en) | 2009-03-12 | 2010-09-16 | Charité - Universitätsmedizin Berlin | Bone morphogenetic protein 2 (bmp2) variants with reduced bmp antagonist sensitivity |
| WO2010144696A1 (en) | 2009-06-11 | 2010-12-16 | Burnham Institute For Medical Research | Directed differentiation of stem cells |
| US8871459B2 (en) | 2009-08-07 | 2014-10-28 | Astute Medical, Inc. | Method for evaluating renal status by determining beta-2-glycoprotein 1 |
| AU2010295509A1 (en) | 2009-09-17 | 2012-04-19 | Stryker Corporation | Buffers for controlling the pH of bone morphogenetic proteins |
| US10324093B2 (en) | 2009-11-07 | 2019-06-18 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| NZ600828A (en) | 2009-12-20 | 2014-09-26 | Astute Medical Inc | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| CA2785038A1 (en) | 2009-12-22 | 2011-07-21 | Stryker Corporation | Bmp-7 variants with reduced immunogenicity |
| SI2666872T1 (sl) | 2010-02-05 | 2016-08-31 | Astute Medical, Inc. | Postopki in sestavki za diagnozo in prognozo ledvične poškodbe in odpovedi ledvic |
| KR20140051754A (ko) | 2010-02-26 | 2014-05-02 | 아스튜트 메디컬 인코포레이티드 | 신장 손상 및 신부전의 진단 및 예후를 위한 방법 및 조성물 |
| EP2576587B1 (en) | 2010-05-24 | 2018-03-21 | The Trustees of Columbia University in the City of New York | Mutant ngal proteins and uses thereof |
| EP2585825B1 (en) | 2010-06-23 | 2018-01-10 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| NZ605698A (en) | 2010-06-23 | 2015-03-27 | Astute Medical Inc | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| KR101800596B1 (ko) | 2010-08-20 | 2017-11-22 | 와이어쓰 엘엘씨 | 디자이너 골형성 단백질 |
| US9688735B2 (en) | 2010-08-20 | 2017-06-27 | Wyeth Llc | Designer osteogenic proteins |
| EP3540440B1 (en) | 2011-12-08 | 2022-09-28 | Astute Medical, Inc. | Methods and uses for evaluating renal injury and renal status |
| US10813946B2 (en) | 2012-10-08 | 2020-10-27 | Vifor (International) Ltd. | Potassium binding polymers for treating hypertension and hyperkalemia |
| WO2014081980A2 (en) | 2012-11-21 | 2014-05-30 | The Trustees Of Columbia University In The City Of New York | Mutant ngal proteins and uses thereof |
| EP4105657B1 (en) | 2013-01-17 | 2024-09-25 | Astute Medical, Inc. | Methods and compositions for diagnosis and prognosis of renal injury and renal failure |
| US8956829B2 (en) | 2013-01-25 | 2015-02-17 | Warsaw Orthopedic, Inc. | Human recombinant growth and differentiaton factor-5 (rhGDF-5) |
| US9359417B2 (en) | 2013-01-25 | 2016-06-07 | Warsaw Orthopedic, Inc. | Cell cultures and methods of human recombinant growth and differentiaton factor-5 (rhGDF-5) |
| US9051389B2 (en) | 2013-01-25 | 2015-06-09 | Warsaw Orthopedic, Inc. | Expression conditions and methods of human recombinant growth and differentiation factor-5 (rhGDF-5) |
| US8945872B2 (en) | 2013-01-25 | 2015-02-03 | Warsaw Orthopedic, Inc. | Methods of purifying human recombinant growth and differentiation factor-5 (rhGDF-5) protein |
| US9169308B2 (en) | 2013-01-25 | 2015-10-27 | Warsaw Orthopedic, Inc. | Methods and compositions of human recombinant growth and differentiation factor-5 (rhGDF-5) isolated from inclusion bodies |
| EP2784083A1 (en) | 2013-03-28 | 2014-10-01 | Charité - Universitätsmedizin Berlin | Bone Morphogenetic Protein (BMP) variants with highly reduced antagonist sensitivity and enhanced specific biological activity |
| EP3069149B1 (en) * | 2013-11-11 | 2022-05-18 | General Electric Company | Method for reducing error in rotor speed measurements |
| EP2944326B1 (en) | 2014-05-16 | 2018-11-21 | Cyanagen Srl | Tricarbocyanine-cyclodextrin-conjugates and their use for the diagnosis of kidney diseases |
| EP3543339A1 (en) | 2015-02-13 | 2019-09-25 | Factor Bioscience Inc. | Nucleic acid products and methods of administration thereof |
| AU2017277305A1 (en) | 2016-06-06 | 2018-12-20 | Astute Medical, Inc. | Management of acute kidney injury using insulin-like growth factor-binding protein 7 and tissue inhibitor of metalloproteinase 2 |
| CN109803977B (zh) | 2016-08-17 | 2023-03-17 | 菲克特生物科学股份有限公司 | 核酸产品及其施用方法 |
| JP2019039673A (ja) * | 2017-08-22 | 2019-03-14 | セイコーエプソン株式会社 | 時間デジタル変換回路、回路装置、物理量測定装置、電子機器及び移動体 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1156741B (it) * | 1978-05-15 | 1987-02-04 | Sigma Tau Ind Farmaceuti | Applicazione terapeutica della carnitina e di alcuni derivati acilati della carnitina nell'emodialisi |
| US4342828A (en) | 1979-07-20 | 1982-08-03 | Morinaga Milk Industry Co., Ltd. | Method for producing substance capable of stimulating differentiation and proliferation of human granulopoietic stem cells |
| US4627839A (en) * | 1985-11-21 | 1986-12-09 | American Hospital Supply Corporation | Patient controlled analgesia conversion |
| US5013649A (en) | 1986-07-01 | 1991-05-07 | Genetics Institute, Inc. | DNA sequences encoding osteoinductive products |
| IL83003A (en) | 1986-07-01 | 1995-07-31 | Genetics Inst | Osteoinductive factors |
| US5011691A (en) | 1988-08-15 | 1991-04-30 | Stryker Corporation | Osteogenic devices |
| US5266683A (en) | 1988-04-08 | 1993-11-30 | Stryker Corporation | Osteogenic proteins |
| US5045452A (en) | 1988-09-02 | 1991-09-03 | Brigham And Women's Hospital | Method for evaluating nephrotoxicity |
| CA2030518C (en) | 1989-03-28 | 2000-03-21 | Elizabeth A. Wang | Osteoinductive compositions |
| DK0536186T3 (da) | 1990-05-16 | 2002-05-21 | Genetics Inst | Knogle- og brusk-dannelsesfremkaldende proteiner |
| JPH0426624A (ja) * | 1990-05-18 | 1992-01-29 | Tsumura & Co | 慢性腎不全改善剤 |
| JPH05509086A (ja) * | 1990-06-22 | 1993-12-16 | イー・アイ・デュポン・ドゥ・ヌムール・アンド・カンパニー | イミダゾールアンジオテンシン―２受容体拮抗薬による慢性腎不全の治療 |
| US6077823A (en) * | 1991-03-11 | 2000-06-20 | Creative Biomolecules, Inc. | Method for reducing tissue damage associated with ischemia-reperfusion or hypoxia injury |
| US6194376B1 (en) * | 1991-03-11 | 2001-02-27 | Creative Biomolecules, Inc. | Method for modulating inflammatory response comprising administering morphogen |
| DK0575555T3 (da) | 1991-03-11 | 2001-11-05 | Curis Inc | Proteininduceret morfogenese |
| CA2363965C (en) * | 1991-03-11 | 2010-05-18 | Curis, Inc. | Protein-induced morphogenesis |
| US7056882B2 (en) * | 1991-03-11 | 2006-06-06 | Curis, Inc. | Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases |
| US5849686A (en) * | 1991-03-11 | 1998-12-15 | Creative Biomolecules, Inc. | Morphogen-induced liver regeneration |
| US6287816B1 (en) | 1991-06-25 | 2001-09-11 | Genetics Institute, Inc. | BMP-9 compositions |
| ES2149776T5 (es) | 1991-08-30 | 2004-07-01 | Curis, Inc. | Modulacion, inducida por un morfogeno, de la respuesta inflamatoria. |
| CA2116560C (en) | 1991-08-30 | 2002-01-08 | Charles M. Cohen | Morphogenic protein screening method |
| EP1637156A1 (en) | 1991-08-30 | 2006-03-22 | Curis, Inc. | Systemic administration of osteogenic proteins in the treatment of metabolic bone diseases |
| US6120760A (en) * | 1992-02-12 | 2000-09-19 | Biopharm Gesellschaft Zur Biotechnologischen Entwicklung | Growth/differentiation factors of the TGF-β family |
| JPH07509720A (ja) | 1992-07-31 | 1995-10-26 | クリエイティブ バイオモレキュルズ，インコーポレイテッド | モルフォゲン強化栄養組成物 |
| KR950702627A (ko) | 1992-07-31 | 1995-07-29 | 찰스 엠. 코헨 | 모르포겐 단백질의 가용성 복합체 및 그의 조성물(Morphogenic Protein Soluble Complex and Composition Thereof) |
| EP0653942B2 (en) | 1992-07-31 | 2007-03-07 | Curis, Inc. | Morphogen-induced nerve regeneration and repair |
| DK0661987T3 (da) | 1992-09-16 | 1998-09-14 | Creative Biomolecules Inc | Morphogeninduceret leverregeneration |
| AU681362B2 (en) | 1992-11-03 | 1997-08-28 | Stryker Corporation | OP-3-induced morphogenesis |
| US5372335A (en) | 1992-12-18 | 1994-12-13 | Scott H. Yenzer | Aerial marker ball and method of placement |
| DE69434914T2 (de) | 1993-03-04 | 2007-10-31 | Stryker Corp., Kalamazoo | Verfahren und zusammensetzungen zur herstellung von rekombinantem osteogenischem protein |
| US5631159A (en) | 1993-09-22 | 1997-05-20 | Creative Biomolecules, Inc. | Lipid-modified serum free media |
| US5585237A (en) | 1993-10-25 | 1996-12-17 | Creative Biomolecules, Inc. | Methods and compositions for high protein production from recombinant DNA |
| ATE225666T1 (de) * | 1993-11-15 | 2002-10-15 | Celtrix Pharma | Verwendung von igf-1 und igfbp-3 zur herstellung eines arzneimittels zur behandlung von einer nierenerkrankung |
| US5525621A (en) * | 1994-05-20 | 1996-06-11 | Cytos Pharmaceuticals Llc | Imidazole derivatives as protective agents in reperfusion injury and severe inflammatory responses |
| US5714511A (en) | 1995-07-31 | 1998-02-03 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Selective prevention of organ injury in sepsis and shock using selection release of nitric oxide in vulnerable organs |
| US5723411A (en) * | 1995-10-31 | 1998-03-03 | E. I. Du Pont De Nemours And Company | Herbicidal pyridazinones |
| DE69723429T3 (de) * | 1996-03-22 | 2007-09-20 | Curis, Inc., Cambridge | Verfahren zur verbesserten funktionellen Erholung der motorischen Koordination, der Sprache oder Sinneswahrnehmung nach Trauma oder Ischämie des ZNS |
| US5820589A (en) * | 1996-04-30 | 1998-10-13 | Medtronic, Inc. | Implantable non-invasive rate-adjustable pump |
| US6498142B1 (en) | 1996-05-06 | 2002-12-24 | Curis, Inc. | Morphogen treatment for chronic renal failure |
| US5879908A (en) * | 1997-04-30 | 1999-03-09 | Smithkline Beecham Corporation | CRFG-1a, a target and marker for chronic renal failure |
| US7147839B2 (en) * | 1998-05-29 | 2006-12-12 | Curis, Inc. | Methods for evaluating tissue morphogenesis and activity |
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1996
- 1996-05-06 US US08/643,321 patent/US6498142B1/en not_active Expired - Lifetime
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1997
- 1997-05-06 DK DK97923567T patent/DK0910400T3/da active
- 1997-05-06 JP JP09540150A patent/JP2000510835A/ja active Pending
- 1997-05-06 US US08/851,628 patent/US6861404B1/en not_active Expired - Fee Related
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- 1997-05-06 AT AT97922726T patent/ATE277629T1/de active
- 1997-05-06 DE DE69723845T patent/DE69723845T2/de not_active Expired - Lifetime
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- 1997-05-06 EP EP97923567A patent/EP0910400B1/en not_active Expired - Lifetime
- 1997-05-06 CA CA002254954A patent/CA2254954C/en not_active Expired - Fee Related
- 1997-05-06 AT AT97923567T patent/ATE245997T1/de not_active IP Right Cessation
- 1997-05-06 PT PT97922726T patent/PT914146E/pt unknown
- 1997-05-06 AU AU28322/97A patent/AU2832297A/en not_active Abandoned
- 1997-05-06 CA CA002254953A patent/CA2254953C/en not_active Expired - Fee Related
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- 1997-05-06 ES ES97923567T patent/ES2203803T3/es not_active Expired - Lifetime
- 1997-05-06 WO PCT/US1997/007816 patent/WO1997041881A1/en not_active Ceased
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