CA2253811C - Taste masked liquid suspensions - Google Patents
Taste masked liquid suspensions Download PDFInfo
- Publication number
- CA2253811C CA2253811C CA002253811A CA2253811A CA2253811C CA 2253811 C CA2253811 C CA 2253811C CA 002253811 A CA002253811 A CA 002253811A CA 2253811 A CA2253811 A CA 2253811A CA 2253811 C CA2253811 C CA 2253811C
- Authority
- CA
- Canada
- Prior art keywords
- active ingredient
- pharmaceutically active
- pharmaceutical composition
- polymer
- taste masked
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 235000019640 taste Nutrition 0.000 title claims abstract description 68
- 239000006194 liquid suspension Substances 0.000 title description 3
- 229920000642 polymer Polymers 0.000 claims abstract description 86
- 239000004480 active ingredient Substances 0.000 claims abstract description 74
- 239000000725 suspension Substances 0.000 claims abstract description 46
- 239000008203 oral pharmaceutical composition Substances 0.000 claims abstract description 27
- 125000001453 quaternary ammonium group Chemical group 0.000 claims abstract description 16
- 230000001419 dependent effect Effects 0.000 claims abstract description 10
- 239000003094 microcapsule Substances 0.000 claims abstract description 10
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 7
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- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
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- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O ammonium group Chemical group [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
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- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
- 229960003438 aspartame Drugs 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
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- NEDGUIRITORSKL-UHFFFAOYSA-N butyl 2-methylprop-2-enoate;2-(dimethylamino)ethyl 2-methylprop-2-enoate;methyl 2-methylprop-2-enoate Chemical compound COC(=O)C(C)=C.CCCCOC(=O)C(C)=C.CN(C)CCOC(=O)C(C)=C NEDGUIRITORSKL-UHFFFAOYSA-N 0.000 description 1
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- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
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- WVWZXTJUCNEUAE-UHFFFAOYSA-M potassium;1,2-bis(ethenyl)benzene;2-methylprop-2-enoate Chemical compound [K+].CC(=C)C([O-])=O.C=CC1=CC=CC=C1C=C WVWZXTJUCNEUAE-UHFFFAOYSA-M 0.000 description 1
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- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPN9697A AUPN969796A0 (en) | 1996-05-07 | 1996-05-07 | Taste masked liquid suspensions |
| AUPN9697 | 1996-05-07 | ||
| PCT/AU1997/000279 WO1997041839A1 (en) | 1996-05-07 | 1997-05-07 | Taste masked liquid suspensions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2253811A1 CA2253811A1 (en) | 1997-11-13 |
| CA2253811C true CA2253811C (en) | 2006-10-24 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002253811A Expired - Fee Related CA2253811C (en) | 1996-05-07 | 1997-05-07 | Taste masked liquid suspensions |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6197348B1 (enExample) |
| EP (1) | EP0921789B1 (enExample) |
| JP (1) | JP4624498B2 (enExample) |
| AT (1) | ATE258432T1 (enExample) |
| AU (1) | AUPN969796A0 (enExample) |
| CA (1) | CA2253811C (enExample) |
| DE (1) | DE69727386T2 (enExample) |
| DK (1) | DK0921789T3 (enExample) |
| ES (1) | ES2215223T3 (enExample) |
| PT (1) | PT921789E (enExample) |
| WO (1) | WO1997041839A1 (enExample) |
Families Citing this family (66)
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| FR2754177B1 (fr) * | 1996-10-07 | 1999-08-06 | Sanofi Sa | Microspheres pharmaceutiques d'acide valproique pour administration orale |
| DE19809719A1 (de) | 1998-03-06 | 1999-09-09 | Roehm Gmbh | Wäßrige Dispersion geeignet zur Herstellung von Überzugs- und Bindemitteln für feste orale Arzneiformen |
| DE19845358A1 (de) * | 1998-10-02 | 2000-04-06 | Roehm Gmbh | Überzogene Arzneiformen mit kontrollierter Wirkstoffabgabe |
| JP5420126B2 (ja) * | 1999-02-04 | 2014-02-19 | アボット・ラボラトリーズ | ｐＨ非依存延長放出性医薬組成物 |
| EP1064938A1 (en) * | 1999-06-28 | 2001-01-03 | Sanofi-Synthelabo | Pharmaceutical dosage forms for controlled release producing at least a timed pulse |
| PT1616561E (pt) * | 1999-12-28 | 2008-07-09 | Ajinomoto Kk | Preparação antidiabética para administração oral |
| HRP20020709A2 (en) * | 2000-02-29 | 2004-12-31 | Teva Pharma | Processes for preparing clarithromycin and clarithromycin intermediate, essentially oxime-free clarithromycin, and pharmaceutical composition comprising the same |
| FR2826274B1 (fr) * | 2001-06-21 | 2003-09-26 | Aventis Pharma Sa | Formulation pharmaceutique au gout masque et son procede de preparation |
| PT1469833T (pt) | 2002-02-01 | 2021-07-13 | Bend Res Inc | Método para produzir dispersões de fármaco amorfo sólido seco por pulverização homogéneas utilizando aparelho de secagem por pulverização modificado |
| NZ534746A (en) * | 2002-03-12 | 2006-06-30 | Bristol Myers Squibb Co | Palatable oral suspension and method |
| US6930119B2 (en) * | 2002-07-17 | 2005-08-16 | Reliant Pharmaceuticals, Inc. | Liquid pharmaceutical composition |
| CA2499550C (en) * | 2002-09-20 | 2013-10-15 | Alpharma, Inc. | Sequestering subunit and related compositions and methods |
| US20040091544A1 (en) * | 2002-11-08 | 2004-05-13 | Ruff Michael D. | Coated dibasic calcium phosphate |
| US20040170686A1 (en) * | 2003-01-31 | 2004-09-02 | Fredrickson Jennifer K. | Suspension vehicle for coated drug particles |
| US20040186180A1 (en) | 2003-03-21 | 2004-09-23 | Gelotte Cathy K. | Non-steroidal anti-inflammatory drug dosing regimen |
| US20040191326A1 (en) * | 2003-03-31 | 2004-09-30 | Reo Joseph P. | Taste-masking vehicle for coated oxazolidinone particles |
| US7520489B2 (en) * | 2003-06-17 | 2009-04-21 | Filtertek Inc. | Fluid handling device and method of making same |
| CL2004001884A1 (es) * | 2003-08-04 | 2005-06-03 | Pfizer Prod Inc | Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros. |
| US20050137262A1 (en) * | 2003-12-22 | 2005-06-23 | Hu Patrick C. | Highly concentrated pourable aqueous solutions of potassium ibuprofen, their preparation and their uses |
| EP1763337A2 (en) * | 2003-12-31 | 2007-03-21 | Actavis Group HF | Immediate, controlled and sustained release formulations of galanthamine |
| EP1776089A2 (en) * | 2003-12-31 | 2007-04-25 | Actavis Group hf | Donepezil formulations |
| US20050163837A1 (en) * | 2003-12-31 | 2005-07-28 | Garth Boehm | Rosiglitazone formulations |
| US20050163843A1 (en) * | 2003-12-31 | 2005-07-28 | Garth Boehm | Alprazolam formulations |
| EP1703898A2 (en) * | 2003-12-31 | 2006-09-27 | Alpharma, Inc. | Ziprasidone formulations |
| CA2552064A1 (en) * | 2003-12-31 | 2005-07-21 | Actavis Group Hf | Atomoxetine formulations |
| US20050142193A1 (en) * | 2003-12-31 | 2005-06-30 | Lijuan Tang | Galantamine formulations |
| WO2005065663A1 (en) * | 2003-12-31 | 2005-07-21 | Alpharma, Inc. | Rosiglitazone and metformin formulations |
| CA2577852A1 (en) * | 2004-08-31 | 2006-03-09 | Pfizer Products Inc. | Pharmaceutical dosage forms comprising a low-solubility drug and a polymer |
| GB2419094A (en) * | 2004-10-12 | 2006-04-19 | Sandoz Ag | Pharmaceutical composition of unpleasnt tasing active substances |
| US7378109B2 (en) * | 2004-12-23 | 2008-05-27 | Council Of Scientific And Industrial Research | Pharmaceutical composition for improving palatability of drugs and process for preparation thereof |
| US20060205682A1 (en) * | 2005-02-25 | 2006-09-14 | Roberts Richard H | Antibiotic and combinations of antibiotic and symptomatic relief agent formulations |
| BRPI0611272A2 (pt) * | 2005-05-03 | 2011-11-16 | Mutual Pharmaceutical Co | formulações de quinina |
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| JP2007031407A (ja) * | 2005-07-29 | 2007-02-08 | Shin Etsu Chem Co Ltd | 低置換度セルロースエーテル含有コーティング用組成物及び不快な味が隠蔽されたフィルムコーティング製剤 |
| US20070087056A1 (en) * | 2005-08-09 | 2007-04-19 | Claudia Guthmann | Pharmaceutical form with sustained pH-independent active ingredient release for active ingredients having strong pH-dependent solubility |
| US9101160B2 (en) | 2005-11-23 | 2015-08-11 | The Coca-Cola Company | Condiments with high-potency sweetener |
| WO2007109057A2 (en) * | 2006-03-16 | 2007-09-27 | Novartis Ag | Solid dosage form containing a taste masked active agent |
| JP4892264B2 (ja) * | 2006-03-30 | 2012-03-07 | 高田製薬株式会社 | リスペリドン水性液剤 |
| EP2719378B1 (en) | 2006-06-19 | 2016-08-31 | Alpharma Pharmaceuticals LLC | Pharmaceutical compositions |
| US7569612B1 (en) | 2006-08-21 | 2009-08-04 | Mutual Pharmaceutical Company, Inc. | Methods of use of fenofibric acid |
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| US8017168B2 (en) | 2006-11-02 | 2011-09-13 | The Coca-Cola Company | High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith |
| WO2008065502A1 (en) * | 2006-11-29 | 2008-06-05 | Pfizer Products Inc. | Pharmaceutical compositions based on a) nanoparticles comprising enteric polymers and b) casein |
| KR20090094319A (ko) * | 2006-12-26 | 2009-09-04 | 시오노기 앤드 컴파니, 리미티드 | 리스페리돈을 함유하는 구강내붕괴 정제 및 고미억제 제제 |
| JP4941977B2 (ja) * | 2007-04-11 | 2012-05-30 | 大蔵製薬株式会社 | ベンズイソキサゾール誘導体の経口ゼリー状医薬組成物 |
| US20100119612A1 (en) * | 2007-04-17 | 2010-05-13 | Bend Research, Inc | Nanoparticles comprising non-crystalline drug |
| US20100080852A1 (en) * | 2007-05-03 | 2010-04-01 | Ronald Arthur Beyerinck | Phamaceutical composition comprising nanoparticles and casein |
| US8309129B2 (en) * | 2007-05-03 | 2012-11-13 | Bend Research, Inc. | Nanoparticles comprising a drug, ethylcellulose, and a bile salt |
| WO2008135855A2 (en) * | 2007-05-03 | 2008-11-13 | Pfizer Products Inc. | Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and a nonionizable polymer |
| US8974827B2 (en) * | 2007-06-04 | 2015-03-10 | Bend Research, Inc. | Nanoparticles comprising a non-ionizable cellulosic polymer and an amphiphilic non-ionizable block copolymer |
| US9545384B2 (en) | 2007-06-04 | 2017-01-17 | Bend Research, Inc. | Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glocol succinate |
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| EP2240162A4 (en) * | 2007-12-06 | 2013-10-09 | Bend Res Inc | NANOTE PARTICLES WITH A NON-IONIZABLE POLYMER AND AN AMIN-FUNCTIONALIZED METHACRYLATE COPOLYMER |
| US9724362B2 (en) * | 2007-12-06 | 2017-08-08 | Bend Research, Inc. | Pharmaceutical compositions comprising nanoparticles and a resuspending material |
| US8623418B2 (en) * | 2007-12-17 | 2014-01-07 | Alpharma Pharmaceuticals Llc | Pharmaceutical composition |
| CA2709992A1 (en) * | 2007-12-17 | 2009-07-16 | Alpharma Pharmaceuticals, Llc | Abuse resistant pharmaceutical compositions of opiod agonists |
| WO2010110018A1 (ja) | 2009-03-27 | 2010-09-30 | 東レ株式会社 | 被覆固形製剤 |
| US20110150986A1 (en) * | 2009-12-18 | 2011-06-23 | Kristin Arnold | Quinine formulations, method of making, and metho of use thereof |
| SG183993A1 (en) * | 2010-03-09 | 2012-10-30 | Alkermes Pharma Ireland Ltd | Alcohol resistant enteric pharmaceutical compositions |
| WO2013156163A1 (en) | 2012-04-19 | 2013-10-24 | Glatt Ag | Taste-masked pharmaceutical compositions containing diclofenac |
| PL2919903T3 (pl) | 2012-11-14 | 2020-12-14 | W.R. Grace & Co. - Conn. | Kompozycje zawierające materiał biologicznie aktywny i nieuporządkowany tlenek nieorganiczny |
| WO2017057884A1 (ko) * | 2015-09-30 | 2017-04-06 | (주)아모레퍼시픽 | 자가회복 가능한 코어-쉘 캡슐 |
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| WO2020011938A1 (en) | 2018-07-11 | 2020-01-16 | Medizinische Universität Wien | Glucocorticoids for the topical treatment of autoimmune gastritis |
| CN113181133A (zh) * | 2021-04-25 | 2021-07-30 | 海南通用三洋药业有限公司 | 一种罗红霉素胶囊的制备方法 |
| CN116687843A (zh) * | 2022-12-16 | 2023-09-05 | 中国人民解放军军事科学院军事医学研究院 | 一种高稳定性的布瓦西坦溶液及其制备方法和其应用 |
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| IE58110B1 (en) * | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
| US5286489A (en) * | 1985-08-26 | 1994-02-15 | The Procter & Gamble Company | Taste masking compositions |
| JPS63150220A (ja) * | 1986-12-15 | 1988-06-22 | Dainippon Pharmaceut Co Ltd | 経口用固形製剤の製造方法 |
| JPS63218247A (ja) * | 1987-03-06 | 1988-09-12 | Yoshiaki Kawashima | 高機能懸濁液 |
| DE58903964D1 (de) * | 1988-11-10 | 1993-05-06 | Ciba Geigy Ag | Fluessige orale formulierung. |
| US5084278A (en) * | 1989-06-02 | 1992-01-28 | Nortec Development Associates, Inc. | Taste-masked pharmaceutical compositions |
| IT1246383B (it) * | 1990-04-17 | 1994-11-18 | Eurand Int | Metodo per il mascheramento del sapore di farmaci |
| CA2085342A1 (en) * | 1990-06-14 | 1991-12-15 | Milton R. Kaplan | Stable aqueous drug suspensions |
| GB9015822D0 (en) * | 1990-07-18 | 1990-09-05 | Beecham Group Plc | Compositions |
| CA2068402C (en) * | 1991-06-14 | 1998-09-22 | Michael R. Hoy | Taste mask coatings for preparation of chewable pharmaceutical tablets |
| DE4200821A1 (de) * | 1992-01-15 | 1993-07-22 | Bayer Ag | Geschmacksmaskierte pharmazeutische mittel |
| JP3265680B2 (ja) * | 1992-03-12 | 2002-03-11 | 大正製薬株式会社 | 経口製剤用組成物 |
| JP3839467B2 (ja) * | 1992-06-04 | 2006-11-01 | スミスクライン・ビーチャム・コーポレイション | 味の良い医薬組成物 |
| AU6774694A (en) * | 1993-04-26 | 1994-11-21 | Affinity Biotech, Inc. | Taste-masking pharmaceutical compositions and methods for making the same |
| ZA945944B (en) * | 1993-08-13 | 1996-02-08 | Eurand America Inc | Procedure for encapsulating nsaids |
-
1996
- 1996-05-07 AU AUPN9697A patent/AUPN969796A0/en not_active Abandoned
-
1997
- 1997-05-07 WO PCT/AU1997/000279 patent/WO1997041839A1/en not_active Ceased
- 1997-05-07 DK DK97917939T patent/DK0921789T3/da active
- 1997-05-07 JP JP53935397A patent/JP4624498B2/ja not_active Expired - Fee Related
- 1997-05-07 US US09/180,354 patent/US6197348B1/en not_active Expired - Fee Related
- 1997-05-07 EP EP97917939A patent/EP0921789B1/en not_active Expired - Lifetime
- 1997-05-07 CA CA002253811A patent/CA2253811C/en not_active Expired - Fee Related
- 1997-05-07 ES ES97917939T patent/ES2215223T3/es not_active Expired - Lifetime
- 1997-05-07 PT PT97917939T patent/PT921789E/pt unknown
- 1997-05-07 AT AT97917939T patent/ATE258432T1/de active
- 1997-05-07 DE DE69727386T patent/DE69727386T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0921789A4 (en) | 2002-03-13 |
| ATE258432T1 (de) | 2004-02-15 |
| DK0921789T3 (da) | 2004-06-01 |
| AUPN969796A0 (en) | 1996-05-30 |
| JP4624498B2 (ja) | 2011-02-02 |
| JP2000509399A (ja) | 2000-07-25 |
| DE69727386D1 (de) | 2004-03-04 |
| US6197348B1 (en) | 2001-03-06 |
| CA2253811A1 (en) | 1997-11-13 |
| PT921789E (pt) | 2004-06-30 |
| DE69727386T2 (de) | 2004-11-11 |
| EP0921789A1 (en) | 1999-06-16 |
| ES2215223T3 (es) | 2004-10-01 |
| WO1997041839A1 (en) | 1997-11-13 |
| EP0921789B1 (en) | 2004-01-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20140507 |