CA2234817A1 - Wet granulation formulation of a growth hormone secretagogue - Google Patents

Wet granulation formulation of a growth hormone secretagogue Download PDF

Info

Publication number
CA2234817A1
CA2234817A1 CA 2234817 CA2234817A CA2234817A1 CA 2234817 A1 CA2234817 A1 CA 2234817A1 CA 2234817 CA2234817 CA 2234817 CA 2234817 A CA2234817 A CA 2234817A CA 2234817 A1 CA2234817 A1 CA 2234817A1
Authority
CA
Canada
Prior art keywords
weight
active ingredient
diluent
carbonyl
piperdin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2234817
Other languages
English (en)
French (fr)
Inventor
Mandana Asgharnejad
Jerome P. Draper
David C. Dubost
Michael J. Kaufman
David E. Storey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9603238.8A external-priority patent/GB9603238D0/en
Priority claimed from GBGB9603834.4A external-priority patent/GB9603834D0/en
Application filed by Individual filed Critical Individual
Publication of CA2234817A1 publication Critical patent/CA2234817A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA 2234817 1995-10-27 1996-10-23 Wet granulation formulation of a growth hormone secretagogue Abandoned CA2234817A1 (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US589795P 1995-10-27 1995-10-27
US590195P 1995-10-27 1995-10-27
US60/005,901 1995-10-27
US60/005,897 1995-10-27
GBGB9603238.8A GB9603238D0 (en) 1996-02-16 1996-02-16 Wet granulation formulation of a growth hormone secretagogue
GB9603238.8 1996-02-16
GB9603834.4 1996-02-23
GBGB9603834.4A GB9603834D0 (en) 1996-02-23 1996-02-23 Amorphous form of a growth hormone secretagogue

Publications (1)

Publication Number Publication Date
CA2234817A1 true CA2234817A1 (en) 1997-05-01

Family

ID=27451404

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2234817 Abandoned CA2234817A1 (en) 1995-10-27 1996-10-23 Wet granulation formulation of a growth hormone secretagogue

Country Status (5)

Country Link
EP (1) EP0857020A4 (ja)
JP (1) JPH11513989A (ja)
AU (1) AU7522896A (ja)
CA (1) CA2234817A1 (ja)
WO (1) WO1997015191A1 (ja)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100699404B1 (ko) 1999-02-18 2007-03-23 가켄 세야쿠 가부시키가이샤 성장 호르몬 분비촉진제로서의 신규 아미드 유도체
JP4644402B2 (ja) * 1999-07-26 2011-03-02 ベイラー カレッジ オブ メディスン 超高活性ブタ成長ホルモン放出ホルモン類似体
MXPA02004650A (es) * 1999-11-12 2002-09-02 Scherer Technologies Inc R P Granulos amortiguadores de celulosa microcristalina.
AU2001276608A1 (en) * 2000-08-30 2002-03-13 Pfizer Products Inc. Sustained release formulations for growth hormone secretagogues
EP1377276B1 (en) * 2001-04-10 2011-10-05 Sun Pharma Advanced Research Company Limited Timed pulse release composition
SI1596870T2 (sl) 2002-12-20 2011-07-29 Hoffmann La Roche Formulacija z visokim odmerkom ibandronata
US7476653B2 (en) 2003-06-18 2009-01-13 Tranzyme Pharma, Inc. Macrocyclic modulators of the ghrelin receptor
UY29527A1 (es) * 2005-05-13 2006-12-29 Schering Ag Composicinn farmaccutica que contienen gestrgenos y/o estrngenos y 5-metil - (6s) - tetrhidrofolato.
CU23558A1 (es) 2006-02-28 2010-07-20 Ct Ingenieria Genetica Biotech Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento
AU2008241532A1 (en) 2007-02-09 2008-10-30 Tranzyme Pharma, Inc. Macrocyclic ghrelin receptor modulators and methods of using the same
JP5637624B2 (ja) * 2009-02-12 2014-12-10 富士化学工業株式会社 崩壊性粒子組成物及びそれを用いた速崩壊性圧縮成型物
US9119832B2 (en) 2014-02-05 2015-09-01 The Regents Of The University Of California Methods of treating mild brain injury
WO2017075535A1 (en) 2015-10-28 2017-05-04 Oxeia Biopharmaceuticals, Inc. Methods of treating neurodegenerative conditions
WO2024096892A1 (en) 2022-11-03 2024-05-10 Lumos Pharma, Inc. Compactable oral formulations of ibutamoren

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5536716A (en) * 1992-12-11 1996-07-16 Merck & Co., Inc. Spiro piperidines and homologs which promote release of growth hormone
EP0813414A4 (en) * 1993-10-19 1999-07-21 Merck & Co Inc COMBINATION OF BISPHOSPHONATES AND THE GROWTH HORMONE SECRETION PROMOTING SUBSTANCES

Also Published As

Publication number Publication date
JPH11513989A (ja) 1999-11-30
AU7522896A (en) 1997-05-15
EP0857020A1 (en) 1998-08-12
EP0857020A4 (en) 1999-01-07
WO1997015191A1 (en) 1997-05-01

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