EP0857020A4 - FORMULATION OF SECRETAGOGUE STIMULATING THE SECRETION OF THE GROWTH HORMONE, INTENDED TO BE GRANULATED BY WET - Google Patents

FORMULATION OF SECRETAGOGUE STIMULATING THE SECRETION OF THE GROWTH HORMONE, INTENDED TO BE GRANULATED BY WET

Info

Publication number
EP0857020A4
EP0857020A4 EP96937761A EP96937761A EP0857020A4 EP 0857020 A4 EP0857020 A4 EP 0857020A4 EP 96937761 A EP96937761 A EP 96937761A EP 96937761 A EP96937761 A EP 96937761A EP 0857020 A4 EP0857020 A4 EP 0857020A4
Authority
EP
European Patent Office
Prior art keywords
growth hormone
wet granulation
hormone secretagogue
granulation formulation
formulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96937761A
Other languages
German (de)
English (en)
French (fr)
Other versions
EP0857020A1 (en
Inventor
Mandana Asgharnejad
Jerome P Draper
David C Dubost
Michael J Kaufman
David E Storey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9603238.8A external-priority patent/GB9603238D0/en
Priority claimed from GBGB9603834.4A external-priority patent/GB9603834D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0857020A1 publication Critical patent/EP0857020A1/en
Publication of EP0857020A4 publication Critical patent/EP0857020A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP96937761A 1995-10-27 1996-10-23 FORMULATION OF SECRETAGOGUE STIMULATING THE SECRETION OF THE GROWTH HORMONE, INTENDED TO BE GRANULATED BY WET Withdrawn EP0857020A4 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US589795P 1995-10-27 1995-10-27
US590195P 1995-10-27 1995-10-27
US5897P 1995-10-27
US5901P 1995-10-27
GBGB9603238.8A GB9603238D0 (en) 1996-02-16 1996-02-16 Wet granulation formulation of a growth hormone secretagogue
GB9603238 1996-02-16
GBGB9603834.4A GB9603834D0 (en) 1996-02-23 1996-02-23 Amorphous form of a growth hormone secretagogue
GB9603834 1996-02-23
PCT/US1996/017196 WO1997015191A1 (en) 1995-10-27 1996-10-23 Wet granulation formulation of a growth hormone secretagogue

Publications (2)

Publication Number Publication Date
EP0857020A1 EP0857020A1 (en) 1998-08-12
EP0857020A4 true EP0857020A4 (en) 1999-01-07

Family

ID=27451404

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96937761A Withdrawn EP0857020A4 (en) 1995-10-27 1996-10-23 FORMULATION OF SECRETAGOGUE STIMULATING THE SECRETION OF THE GROWTH HORMONE, INTENDED TO BE GRANULATED BY WET

Country Status (5)

Country Link
EP (1) EP0857020A4 (ja)
JP (1) JPH11513989A (ja)
AU (1) AU7522896A (ja)
CA (1) CA2234817A1 (ja)
WO (1) WO1997015191A1 (ja)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100699404B1 (ko) 1999-02-18 2007-03-23 가켄 세야쿠 가부시키가이샤 성장 호르몬 분비촉진제로서의 신규 아미드 유도체
JP4644402B2 (ja) * 1999-07-26 2011-03-02 ベイラー カレッジ オブ メディスン 超高活性ブタ成長ホルモン放出ホルモン類似体
MXPA02004650A (es) * 1999-11-12 2002-09-02 Scherer Technologies Inc R P Granulos amortiguadores de celulosa microcristalina.
AU2001276608A1 (en) * 2000-08-30 2002-03-13 Pfizer Products Inc. Sustained release formulations for growth hormone secretagogues
EP1377276B1 (en) * 2001-04-10 2011-10-05 Sun Pharma Advanced Research Company Limited Timed pulse release composition
SI1596870T2 (sl) 2002-12-20 2011-07-29 Hoffmann La Roche Formulacija z visokim odmerkom ibandronata
US7476653B2 (en) 2003-06-18 2009-01-13 Tranzyme Pharma, Inc. Macrocyclic modulators of the ghrelin receptor
UY29527A1 (es) * 2005-05-13 2006-12-29 Schering Ag Composicinn farmaccutica que contienen gestrgenos y/o estrngenos y 5-metil - (6s) - tetrhidrofolato.
CU23558A1 (es) 2006-02-28 2010-07-20 Ct Ingenieria Genetica Biotech Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento
AU2008241532A1 (en) 2007-02-09 2008-10-30 Tranzyme Pharma, Inc. Macrocyclic ghrelin receptor modulators and methods of using the same
JP5637624B2 (ja) * 2009-02-12 2014-12-10 富士化学工業株式会社 崩壊性粒子組成物及びそれを用いた速崩壊性圧縮成型物
US9119832B2 (en) 2014-02-05 2015-09-01 The Regents Of The University Of California Methods of treating mild brain injury
WO2017075535A1 (en) 2015-10-28 2017-05-04 Oxeia Biopharmaceuticals, Inc. Methods of treating neurodegenerative conditions
WO2024096892A1 (en) 2022-11-03 2024-05-10 Lumos Pharma, Inc. Compactable oral formulations of ibutamoren

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995011029A1 (en) * 1993-10-19 1995-04-27 Merck & Co., Inc. Combination of bisphosphonates and growth hormone secretagogues

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5536716A (en) * 1992-12-11 1996-07-16 Merck & Co., Inc. Spiro piperidines and homologs which promote release of growth hormone

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995011029A1 (en) * 1993-10-19 1995-04-27 Merck & Co., Inc. Combination of bisphosphonates and growth hormone secretagogues

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9715191A1 *

Also Published As

Publication number Publication date
JPH11513989A (ja) 1999-11-30
AU7522896A (en) 1997-05-15
CA2234817A1 (en) 1997-05-01
EP0857020A1 (en) 1998-08-12
WO1997015191A1 (en) 1997-05-01

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Legal Events

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