JP5637624B2 - 崩壊性粒子組成物及びそれを用いた速崩壊性圧縮成型物 - Google Patents
崩壊性粒子組成物及びそれを用いた速崩壊性圧縮成型物 Download PDFInfo
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- JP5637624B2 JP5637624B2 JP2010550472A JP2010550472A JP5637624B2 JP 5637624 B2 JP5637624 B2 JP 5637624B2 JP 2010550472 A JP2010550472 A JP 2010550472A JP 2010550472 A JP2010550472 A JP 2010550472A JP 5637624 B2 JP5637624 B2 JP 5637624B2
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- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims description 19
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- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 claims description 6
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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Description
好ましくは、炭酸マグネシウム、炭酸カルシウム、無水ケイ酸、ケイ酸カルシウム、リン酸水素カルシウム及び無水リン酸水素カルシウムから選ばれる少なくとも1種以上である。
好ましくは、ステアリン酸、ステアリン酸マグネシウム、ステアリン酸カルシウム、ショ糖脂肪酸エステル、グリセリン脂肪酸エステル、ポリエチレングリコール、フマル酸ステアリルナトリウム、タルク、硬化油である。
好ましくは、結晶セルロース、クロスカルメロースナトリウム、メタケイ酸アルミン酸マグネシウム、ケイ酸アルミン酸マグネシウム、リン酸水素カルシウム、無水リン酸水素カルシウム、無水リン酸水素カルシウム造粒物、ケイ酸カルシウム、ケイ酸アルミニウム、無水ケイ酸、炭酸マグネシウムである。
好ましくは、低置換度ヒドロキシプロピルセルロース、結晶セルロース、カルメロース、クロスカルメロースナトリウム、カルボキシメチルスターチナトリウム、コメデンプン、トウモロコシデンプン、クロスポビドン、メタケイ酸アルミン酸マグネシウム、ケイ酸アルミン酸マグネシウム、合成ケイ酸アルミニウムである。
利尿薬としては、例えばイソソルピド、フロセミド、ヒドロクロロチアジドなどが挙げられる。
高脂血症用剤としては、例えば、イコサペント酸エチル、セリバスタチンナトリウム、シンバスタチン、プラバスタチンナトリウム、ピタバスタチンカルシウム、アトルバスタチンカルシウム水和物、ベザフィブラート、ロスバスタチンカルシウム、エゼチミブ、及びエゼチミブ+シンバスタチン等の合剤等が挙げられる。
化学療法剤としては、例えばスルファメチゾールなどが挙げられる。
鎮けい剤としては、塩酸メクリジン、ジメンヒドリナートなどが挙げられる。
抗リウマチ薬としては、メソトレキセート、ブシラミンなどが挙げられる。
ホルモン剤としては、例えばリオチロニンナトリウム、リン酸デキメタゾンナトリウム、プレドニゾロン、オキセンドロン、酢酸リュープロレリンなどが挙げられる。
アルカロイド系麻薬として、アヘン、塩酸モルヒネ、トロン、塩酸オキシコドン、塩酸アヘンアルカロイド、塩酸コカインなどが挙げられる。
サルファ剤としては、例えばスルフィソミジン、スルファメチゾールなどが挙げられる。
痛風治療薬としては、例えばアロプリノール、コルヒチンなどが挙げられる。
血液凝固阻止剤としては、例えばジクマロールが挙げられる。
抗悪性腫瘍剤としては、例えば5−フルオロウラシル、ウラシル、マイトマイシン、塩酸マニジピン、ボグリボース、カンデサルタンシレキセチル、塩酸ピオグリタゾンなどが挙げられる。
ビタミン類としては、例えば、アスタキサンチン、ビタミンA、β−カロチン、ルテイン、ゼアキサンチン等のカロチノイド類、フルスルチアミン、塩酸フルスルチアミン、プロスルチアミン、オクトチアミン、チアミンジスルフィド、ビスベンチアミン、ビスブチチアミン、ビスイブチアミン、ベンフォチアミン、塩酸セトチアミン等のビタミンB1もしくはその誘導体又はそれらの塩、リボフラビン、リン酸リボフラビンナトリウム、フラビンアデニンジヌクレオチドナトリウム、酪酸リボフラビン等のビタミンB2もしくはその誘導体又はそれらの塩、アスコルビン酸やアスコルビン酸グルコシド、パルミチン酸L−アスコルビル、L−アスコルビン酸リン酸エステル等のビタミンC誘導体、トコフェロール、酢酸トコフェロール、コハク酸トコフェロール、ニコチン酸トコフェロール、トコトリエノール等のビタミンE類等が挙げられる。
本発明の速崩壊性圧縮成型物は、少量の水で直ちに崩壊することから、医薬品のみならず、食品や健康食品や特定機能食品、ペットフードや飼料、農薬に用いることも可能である。
実施例で得られた各錠剤についての評価は、次の方法により行った。
[口腔内崩壊時間]
錠剤(1錠ずつ n=6)を、3〜8人の被験者が口腔内の舌上に乗せて完全に崩壊するまでの時間を測定し、その平均値を口腔内崩壊時間とした。
[官能試験]
錠剤を、3〜8人の被験者が口腔内の舌上に乗せ、自然に崩壊させた。その後の食感について確認し、過半数が良いと感じた物を「良」とした。
[錠剤の硬度]
ロードセル式錠剤硬度計(PC−30、岡田精工(株)製)を用いて測定した。
[打錠性]
打錠機の臼杵、打錠後の錠剤を観察し、スティッキングやキャッピングを評価した。
キシリトール5重量部、コーンスターチ64重量部、ワキシーコーンスターチ15重量部、結晶セルロース8.5重量部、軽質炭酸マグネシウム5重量部、軽質炭酸カルシウム2.5重量部を水に均一に分散させたのち、噴霧乾燥機(S−50N/R、ニロ社製)を用いて、出口温度90〜100℃で噴霧乾燥し、流動性の良い白色の球状の粒子組成物を得た。
乳糖5重量部、コーンスターチ57.5重量部、ライススターチ(ミクロパール、島田工業(株)製)15重量部、結晶セルロース15重量部、軽質炭酸マグネシウム5重量部、軽質炭酸カルシウム2.5重量部を水に均一に分散させたのち、噴霧乾燥機(S−50N/R、ニロ社製)を用いて、出口温度90〜100℃で噴霧乾燥し、流動性の良い白色の球状の粒子組成物を得た。
グラニュー糖10重量部、コーンスターチ70重量部、炭酸マグネシウム20重量部を水に均一に分散させたのち、噴霧乾燥機(L−8型、大川原化工機社製)を用いて、出口温度90〜100℃で噴霧乾燥し、流動性の良い白色の球状の粒子組成物を得た。
キシリトール10重量部、コーンスターチ70重量部、炭酸マグネシウム20重量部を水に均一に分散させたのち、噴霧乾燥機(L−8型、大川原化工機社製)を用いて、出口温度90〜100℃で噴霧乾燥し、流動性の良い白色の球状の粒子組成物を得た。
コーンスターチ49重量部、ワキシーコーンスターチ30重量部、微結晶セルロース8.5重量部、キシリトール5重量部、炭酸マグネシウム5重量部、炭酸カルシウム2.5重量部を水に均一に分散させたのち、噴霧乾燥機(L−8型、大川原化工機社製)を用いて、出口温度90〜100℃で噴霧乾燥し、流動性の良い白色の球状の粒子組成物を得た。
コーンスターチ49重量部、微結晶セルロース8.5重量部、キシリトール5重量部、炭酸マグネシウム5重量部、炭酸カルシウム2.5重量部を水に均一に分散させたのち、噴霧乾燥機(S−50N/R、ニロ社製)を用いて、出口温度90〜100℃で噴霧乾燥し、流動性の良い白色の球状の粒子組成物を得た。この粒子のSEM写真を図1に示した。
キシリトール5重量部、コーンスターチ64重量部、ワキシーコーンスターチ15重量部、結晶セルロース8.5重量部、軽質炭酸マグネシウム5重量部、軽質炭酸カルシウム2.5重量部をビニール袋に入れてふり混ぜて混合物を得た。この造粒物99.8重量部、ベヘン酸グリセリル(コンプリトール888ATO、ガテホセ社製)0.2重量部を混合したのち、ロータリー打錠機により設定硬度30Nとして打錠し、重量200mg、直径8mm、9Rの錠剤を得ようとしたが、嵩密度が高く均一に充填できず打錠できなかった。
グラニュー糖10重量部、コーンスターチ70重量部、炭酸マグネシウム20重量部をビニール袋に入れてふり混ぜて混合物を得た。この混合物94重量部、CMC−Ca2重量部、シュガーエステル3重量部、サイロページ1重量部を混合したのち、ロータリー打錠機により設定硬度30Nとして打錠し、重量200mg、直径8mm、9Rの錠剤を得ようとしたが、嵩密度が高く均一に充填できず打錠できなかった。
実施例1で製造した造粒物99.8重量部、ベヘン酸グリセリル(コンプリトール888ATO、ガテホセ社製)0.2重量部を混合したのち、ロータリー打錠機により設定硬度30Nとして打錠し、重量200mg、直径8mm、9Rの錠剤を得た。
実施例2で製造した造粒物99.8重量部、ベヘン酸グリセリル(コンプリトール888ATO、ガテホセ社製)0.2重量部を混合したのち、ロータリー打錠機により設定硬度30Nとして打錠し、重量200mg、直径8mm、9Rの錠剤を得た。
実施例1で製造した造粒物94重量部、CMC−Ca2重量部、シュガーエステル3重量部、サイロページ1重量部を混合したのち、ロータリー打錠機により設定硬度30Nとして打錠し、重量200mg、直径8mm、9Rの錠剤を得た。
実施例3で製造した造粒物94重量部、CMC−Ca2重量部、シュガーエステル3重量部、サイロページ1重量部を混合したのち、ロータリー打錠機により設定硬度30Nとして打錠し、重量200mg、直径8mm、9Rの錠剤を得た。
実施例1で製造した造粒物64.68重量部、CMC−Ca2重量部、シュガーエステル3重量部、サイロページ1重量部、コーンスターチ27.72重量部、アスパルテーム0.1重量部、メントール1.5重量部を混合したのち、ロータリー打錠機により設定硬度30Nとして打錠し、重量200mg、直径8mm、9Rの錠剤を得た。
実施例3で製造した造粒物64.68重量部、CMC−Ca2重量部、シュガーエステル3重量部、サイロページ1重量部、コーンスターチ27.72重量部、アスパルテーム0.1重量部、メントール1.5重量部を混合したのち、ロータリー打錠機により設定硬度30Nとして打錠し、重量200mg、直径8mm、9Rの錠剤を得た。
実施例5で製造した造粒物99.6重量部とベヘン酸グリセリル0.4重量部を混合したのち、ロータリー打錠機により設定硬度50Nとして打錠し、重量200mg、直径8mm、9Rの錠剤を得た。
実施例6で製造した造粒物70重量部とコーンスターチ30重量部を混合した。ついでその混合物99.6重量部とベヘン酸グリセリル0.4重量部を混合したのち、ロータリー打錠機により設定硬度50Nとして打錠し、重量200mg、直径8mm、9Rの錠剤を得た。
実施例6で製造した造粒物70重量部とワキシーコーンスターチ30重量部を混合した。ついでその混合物89.6重量部、アセトアミノフェン10重量部、ベヘン酸グリセリル0.4重量部を混合したのち、ロータリー打錠機により設定硬度50Nとして打錠し、重量200mg、直径8mm、9Rの錠剤を得た。
アセトアミノフェン10重量部、コーンスターチ49重量部、微結晶セルロース8.5重量部、キシリトール5重量部、炭酸マグネシウム5重量部、炭酸カルシウム2.5重量部を水に均一に分散させたのち、噴霧乾燥機(L−8型、大川原化工機社製)を用いて、出口温度90〜100℃で噴霧乾燥し、流動性の良い球状の粒子組成物を得た。
この造粒物68重量部、ワキシーコーンスターチ29.2重量部、アスパルテーム0.2重量部、サネットD0.2重量部、オレンジ香料2重量部、ベヘン酸グリセリル0.4重量部を混合したのち、ロータリー打錠機により設定硬度50Nとして打錠し、重量200mg、直径8mm、9Rの錠剤を得た。
コーンスターチ60重量部、グリシン17.5重量部、微結晶セルロース15重量部、炭酸マグネシウム5重量部、炭酸カルシウム2.5重量部を水に均一に分散させたのち、噴霧乾燥機(L−8型、大川原化工機社製)を用いて、出口温度90〜100℃で噴霧乾燥し、流動性の良い球状の粒子組成物を得た。
この造粒物99.8重量部、ベヘン酸グリセリル(コンプリトール888ATO、ガテホセ社製)0.2重量部を混合したのち、ロータリー打錠機により設定硬度30Nとして打錠し、重量200mg、直径8mm、9Rの錠剤を得た。
コーンスターチ60重量部、DL−アラニン17.5重量部、微結晶セルロース15重量部、炭酸マグネシウム5重量部、炭酸カルシウム2.5重量部を水に均一に分散させたのち、噴霧乾燥機(L−8型、大川原化工機社製)を用いて、出口温度90〜100℃で噴霧乾燥し、流動性の良い球状の粒子組成物を得た。ついで、この造粒物99.8重量部、ベヘン酸グリセリル(コンプリトール888ATO、ガテホセ社製)0.2重量部を混合したのち、ロータリー打錠機により設定硬度30Nとして打錠し、重量200mg、直径8mm、9Rの錠剤を製造した。
Claims (9)
- 水溶性結合剤のマトリックス内に平均粒子径1〜300μmのスターチ粒子、成形剤が単分散した複合粒子であって、スターチ類、水溶性結合剤、成形剤の配合比が重量比で1:0.01〜0.75:0.01〜1、平均粒子径が5〜500μmである崩壊性粒子組成物であって、水溶性結合剤が、キシリトール、エリスリトール、マルチトール、ソルビトール、マンニトール、乳糖、ショ糖、ブドウ糖、果糖、麦芽糖、トレハロース、パラチニット、パラチノースから選ばれる糖類、及び/又はグリシン、アラニン、セリン、リシン、トレオニン、システイン、ヒスチジン、アスパラギン、アスパラギン酸、グルタミン、グルタミン酸から選ばれるアミノ酸である少なくとも1種であり、成形剤が、結晶セルロース、及び/又は無機粒子から選ばれる少なくとも1種であり、スターチ類、水溶性結合剤及び成形剤を水に懸濁又は溶解させ噴霧乾燥して得られた崩壊性粒子組成物。
- スターチ類、水溶性結合剤の配合比が重量比で1:0.03〜0.3である請求項1に記載の崩壊性粒子組成物。
- スターチ類が、コーンスターチ、ライススターチ、ポテトスターチ、コムギデンプン、モチコメデンプン、ワキシーコーンスターチ、サツマイモデンプン、タピオカデンプン、部分アルファー化デンプン、デキストリン、クラスターデキストリン、可溶性デンプン、ヒドロキシプロピルスターチ、カルボキシメチルスターチナトリウムから選ばれる少なくとも1種からなる請求項1〜2のいずれか1項に記載の崩壊性粒子組成物。
- スターチ類、成形剤の配合比が、重量比で1:0.1〜0.4である請求項1〜3のいずれかに記載の崩壊性粒子組成物。
- 結晶セルロースと無機粒子の配合比が、重量比で1:0.06〜10である請求項1〜4のいずれか1項に記載の崩壊性粒子組成物。
- 無機粒子が、平均粒子径0.1〜300μmである、炭酸マグネシウム、炭酸カルシウム、リン酸カルシウム、リン酸水素カルシウム、無水リン酸水素カルシウム、メタケイ酸アルミン酸マグネシウム、ケイ酸アルミン酸マグネシウム、ハイドロタルサイト、ケイ酸アルミニウム、ケイ酸カルシウム、ケイ酸マグネシウム、無水ケイ酸、二酸化ケイ素、酸化マグネシウム、水酸化マグネシウム、水酸化アルミナマグネシウム、乾燥水酸化アルミニウムゲルから選ばれる少なくとも1種からなる請求項1〜5のいずれか1項に記載の崩壊性粒子組成物。
- 有効成分を含む請求項1〜6のいずれか1項に記載の崩壊性粒子組成物。
- 請求項1〜7のいずれか1項に記載の崩壊性粒子組成物を含む速崩壊性圧縮成型物。
- 請求項1〜8のいずれか1項に記載の崩壊性粒子組成物100重量部に対して、以下の群から選択される成分を0.01〜1000重量部、必要に応じて有効成分を0.01〜100重量部配合してなる速崩壊性圧縮成型物;
賦形剤、崩壊剤、結合剤、界面活性剤、滑沢剤、酸味料、甘味料、矯味剤、香料、着色剤、安定化剤。
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EP2968181B1 (en) | 2013-03-15 | 2019-10-16 | Aprecia Pharmaceuticals LLC | Rapidly dispersible dosage form of topiramate |
JP6463333B2 (ja) | 2013-03-15 | 2019-01-30 | アプレシア・ファーマスーティカルズ・カンパニー | オキシカルバゼピンの急速分散性の剤形 |
WO2015170195A1 (en) * | 2014-05-03 | 2015-11-12 | GORREPATI, Navaneeta Krishna | Hydrazaline hydrochloride pellets and its preparation method |
JP6578778B2 (ja) * | 2014-08-19 | 2019-09-25 | 大正製薬株式会社 | 固形組成物 |
JP6578779B2 (ja) * | 2014-08-19 | 2019-09-25 | 大正製薬株式会社 | 固形組成物 |
WO2016061486A1 (en) | 2014-10-16 | 2016-04-21 | Cargill, Incorporated | Process for preparing a directly compressible erythritol & uses thereof |
WO2016174664A1 (en) | 2015-04-29 | 2016-11-03 | Dexcel Pharma Technologies Ltd. | Orally disintegrating compositions |
US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
CN109414051A (zh) * | 2016-06-28 | 2019-03-01 | 株式会社日本抗菌总和研究所 | 赋形剂和片剂 |
JP2018108950A (ja) * | 2016-12-28 | 2018-07-12 | 沢井製薬株式会社 | レボセチリジン塩酸塩含有口腔内崩壊錠 |
US20220016074A1 (en) | 2018-11-21 | 2022-01-20 | Rosemont Pharmaceuticals Limited | Oral topiramate suspension formulations with extended shelf stability and enhanced bioavailability |
CN116036040B (zh) * | 2022-11-28 | 2024-06-21 | 四川省中医药科学院中医研究所 | 一种补肺颗粒及其制备方法 |
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Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0977669A (ja) * | 1995-09-19 | 1997-03-25 | Takeda Chem Ind Ltd | ビタミンb群顆粒品の組成物およびその製造方法 |
JPH10120554A (ja) * | 1996-10-15 | 1998-05-12 | Fuji Chem Ind Co Ltd | 無機制酸剤含有速分散性造粒物、その製造方法及び用時懸濁内服制酸剤 |
JPH11310539A (ja) * | 1998-02-26 | 1999-11-09 | Banyu Pharmaceut Co Ltd | 口腔内崩壊型組成物及びその製造方法 |
WO2001076565A1 (fr) * | 2000-04-12 | 2001-10-18 | Banyu Pharmaceutical Co., Ltd. | Compositions et preparations se desintegrant dans la cavite buccale |
JP2003176242A (ja) * | 1996-07-12 | 2003-06-24 | Dai Ichi Seiyaku Co Ltd | 速崩壊性圧縮成型物及びその製造法 |
JP2005515240A (ja) * | 2002-01-18 | 2005-05-26 | ロケット・フルーレ | 固形口腔内分散可能な製剤 |
JP2006008667A (ja) * | 2004-05-26 | 2006-01-12 | Takeda Chem Ind Ltd | ビタミンc類を含む安定化された固形製剤 |
JP2008133232A (ja) * | 2006-11-29 | 2008-06-12 | Ohara Yakuhin Kogyo Kk | 苦味の改善された医薬組成物 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU7522896A (en) * | 1995-10-27 | 1997-05-15 | Merck & Co., Inc. | Wet granulation formulation of a growth hormone secretagogue |
US5837292A (en) * | 1996-07-03 | 1998-11-17 | Yamanouchi Europe B.V. | Granulate for the preparation of fast-disintegrating and fast-dissolving compositions containing a high amount of drug |
JP3182404B2 (ja) | 1998-01-14 | 2001-07-03 | 大日本製薬株式会社 | 口腔内崩壊錠及びその製造方法 |
JP4063386B2 (ja) | 1998-01-29 | 2008-03-19 | キッセイ薬品工業株式会社 | 速放性経口医薬品組成物 |
JP2000086537A (ja) * | 1998-09-11 | 2000-03-28 | Fuji Chem Ind Co Ltd | 無機化合物糖類組成物、賦形剤、速崩壊性圧縮成型物及びその製造方法 |
AU771440B2 (en) * | 1999-12-06 | 2004-03-25 | Edward Mendell Co. Inc. | Pharmaceutical superdisintegrant |
ES2292414T3 (es) * | 2000-07-27 | 2008-03-16 | Roquette Freres | Granulos a base de almidon y de lactosa. |
NZ535261A (en) * | 2000-08-08 | 2004-12-24 | Smithkline Beecham P | A tablet comprising the hydrochloride salt of N-(1-nbutyl-4-piperidinyl)methyl]-3,4-[1,3]oxazino[3,2-a] indole-10-carboxamide |
US20030035833A1 (en) * | 2000-12-06 | 2003-02-20 | Xiaorong He | Rapidly dispersing pharmaceutical composition |
JP2002275054A (ja) | 2001-03-19 | 2002-09-25 | Dainippon Pharmaceut Co Ltd | 易服用性固形製剤 |
JP4726628B2 (ja) | 2003-10-15 | 2011-07-20 | 富士化学工業株式会社 | 口腔内速崩壊性錠剤 |
JP3841804B2 (ja) * | 2003-10-15 | 2006-11-08 | 富士化学工業株式会社 | 口腔内速崩壊性錠剤用の組成物 |
JP2005306770A (ja) * | 2004-04-21 | 2005-11-04 | Toa Eiyo Ltd | 口腔内速崩壊型製剤及びその製造方法 |
JP2008526827A (ja) * | 2005-01-07 | 2008-07-24 | ファイザー・プロダクツ・インク | 5,8,14−トリアザテトラシクロ[10.3.1.02,11.04,9]−ヘキサデカ−2(11),3,5,7,9−ペンタエンの速崩壊性投与形態 |
JP5074190B2 (ja) | 2005-09-02 | 2012-11-14 | 富士化学工業株式会社 | 口腔内速崩壊性錠剤 |
CA2657202A1 (en) * | 2006-07-28 | 2008-01-31 | Farmaprojects, S.A. | Extended release pharmaceutical formulation of metoprolol and process for its preparation |
EP2050448A4 (en) * | 2006-08-08 | 2012-01-04 | Kissei Pharmaceutical | Mouth-dropping tray with masked bitter taste and method of preparation |
-
2010
- 2010-02-12 US US13/148,999 patent/US20120040001A1/en not_active Abandoned
- 2010-02-12 EP EP10741108.4A patent/EP2397161B1/en active Active
- 2010-02-12 ES ES10741108T patent/ES2758624T3/es active Active
- 2010-02-12 JP JP2010550472A patent/JP5637624B2/ja active Active
- 2010-02-12 WO PCT/JP2010/000886 patent/WO2010092828A1/ja active Application Filing
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0977669A (ja) * | 1995-09-19 | 1997-03-25 | Takeda Chem Ind Ltd | ビタミンb群顆粒品の組成物およびその製造方法 |
JP2003176242A (ja) * | 1996-07-12 | 2003-06-24 | Dai Ichi Seiyaku Co Ltd | 速崩壊性圧縮成型物及びその製造法 |
JPH10120554A (ja) * | 1996-10-15 | 1998-05-12 | Fuji Chem Ind Co Ltd | 無機制酸剤含有速分散性造粒物、その製造方法及び用時懸濁内服制酸剤 |
JPH11310539A (ja) * | 1998-02-26 | 1999-11-09 | Banyu Pharmaceut Co Ltd | 口腔内崩壊型組成物及びその製造方法 |
WO2001076565A1 (fr) * | 2000-04-12 | 2001-10-18 | Banyu Pharmaceutical Co., Ltd. | Compositions et preparations se desintegrant dans la cavite buccale |
JP2005515240A (ja) * | 2002-01-18 | 2005-05-26 | ロケット・フルーレ | 固形口腔内分散可能な製剤 |
JP2006008667A (ja) * | 2004-05-26 | 2006-01-12 | Takeda Chem Ind Ltd | ビタミンc類を含む安定化された固形製剤 |
JP2008133232A (ja) * | 2006-11-29 | 2008-06-12 | Ohara Yakuhin Kogyo Kk | 苦味の改善された医薬組成物 |
Also Published As
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JPWO2010092828A1 (ja) | 2012-08-16 |
WO2010092828A1 (ja) | 2010-08-19 |
EP2397161B1 (en) | 2019-09-25 |
US20120040001A1 (en) | 2012-02-16 |
ES2758624T3 (es) | 2020-05-06 |
EP2397161A1 (en) | 2011-12-21 |
EP2397161A4 (en) | 2013-06-05 |
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