CA2207302A1

CA2207302A1 - Neisseria meningitidis subunit tbp2

Neisseria meningitidis subunit tbp2

Info

Publication number: CA2207302A1
Authority: CA; Canada
Prior art keywords: tbp2; gly; ala; thr; lys
Prior art date: 1995-10-10
Legal status : Abandoned

Application number

CA002207302A

Other languages

English (en)

French (fr)

Inventor

Marie-Jose Quentin-Millet

Bachra Rokbi

Current Assignee

Sanofi Pasteur SA

Original Assignee

Individual

Priority date

1995-10-10

Filing date

1996-10-10

Publication date

1997-04-17

1996-10-10 Application filed by Individual filed Critical Individual

1997-04-17 Publication of CA2207302A1 publication Critical patent/CA2207302A1/en

Status Abandoned legal-status Critical Current

Links

101150101515 tbpl2 gene Proteins 0.000 title claims abstract description 253
241000588650 Neisseria meningitidis Species 0.000 title claims abstract description 68
101150080060 TBP2 gene Proteins 0.000 title description 8
101100245206 Dictyostelium discoideum psmC4 gene Proteins 0.000 title description 5
101150095556 tbpB gene Proteins 0.000 title description 5
108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 84
229920001184 polypeptide Polymers 0.000 claims abstract description 74
102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 74
239000012634 fragment Substances 0.000 claims abstract description 48
108090000623 proteins and genes Proteins 0.000 claims abstract description 41
102000004169 proteins and genes Human genes 0.000 claims abstract description 39
101000766306 Homo sapiens Serotransferrin Proteins 0.000 claims abstract description 20
XNSAINXGIQZQOO-SRVKXCTJSA-N protirelin Chemical compound NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H]1NC(=O)CC1)CC1=CN=CN1 XNSAINXGIQZQOO-SRVKXCTJSA-N 0.000 claims abstract description 20
102000007238 Transferrin Receptors Human genes 0.000 claims abstract description 14
125000003275 alpha amino acid group Chemical group 0.000 claims description 80
238000012217 deletion Methods 0.000 claims description 50
230000037430 deletion Effects 0.000 claims description 50
150000001413 amino acids Chemical class 0.000 claims description 40
239000012528 membrane Substances 0.000 claims description 40
239000000203 mixture Substances 0.000 claims description 27
238000001262 western blot Methods 0.000 claims description 23
210000004899 c-terminal region Anatomy 0.000 claims description 10
239000008194 pharmaceutical composition Substances 0.000 claims description 7
101150043772 psmC3 gene Proteins 0.000 claims 1
229960005486 vaccine Drugs 0.000 abstract description 7
238000003556 assay Methods 0.000 abstract 1
108020004414 DNA Proteins 0.000 description 64
235000018102 proteins Nutrition 0.000 description 37
210000002966 serum Anatomy 0.000 description 36
239000000872 buffer Substances 0.000 description 34
BYXHQQCXAJARLQ-ZLUOBGJFSA-N Ala-Ala-Ala Chemical compound C[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(O)=O BYXHQQCXAJARLQ-ZLUOBGJFSA-N 0.000 description 30
238000000034 method Methods 0.000 description 23
239000013612 plasmid Substances 0.000 description 23
238000002360 preparation method Methods 0.000 description 21
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 20
239000002773 nucleotide Substances 0.000 description 20
125000003729 nucleotide group Chemical group 0.000 description 20
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VPZXBVLAVMBEQI-UHFFFAOYSA-N glycyl-DL-alpha-alanine Natural products OC(=O)C(C)NC(=O)CN VPZXBVLAVMBEQI-UHFFFAOYSA-N 0.000 description 17
244000005700 microbiome Species 0.000 description 17
108010079364 N-glycylalanine Proteins 0.000 description 15
CTQIOCMSIJATNX-WHFBIAKZSA-N Asn-Gly-Ala Chemical compound [H]N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(O)=O CTQIOCMSIJATNX-WHFBIAKZSA-N 0.000 description 14
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LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 13
229940072417 peroxidase Drugs 0.000 description 13
RLMISHABBKUNFO-WHFBIAKZSA-N Ala-Ala-Gly Chemical compound C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(O)=O RLMISHABBKUNFO-WHFBIAKZSA-N 0.000 description 12
OBVSBEYOMDWLRJ-BFHQHQDPSA-N Ala-Gly-Thr Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)CNC(=O)[C@H](C)N OBVSBEYOMDWLRJ-BFHQHQDPSA-N 0.000 description 12
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QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 11
BUANFPRKJKJSRR-ACZMJKKPSA-N Ala-Ala-Gln Chemical compound C[C@H]([NH3+])C(=O)N[C@@H](C)C(=O)N[C@H](C([O-])=O)CCC(N)=O BUANFPRKJKJSRR-ACZMJKKPSA-N 0.000 description 11
YYSWCHMLFJLLBJ-ZLUOBGJFSA-N Ala-Ala-Ser Chemical compound C[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(O)=O YYSWCHMLFJLLBJ-ZLUOBGJFSA-N 0.000 description 11
241000894006 Bacteria Species 0.000 description 11
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230000001580 bacterial effect Effects 0.000 description 11
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KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 description 11
238000003756 stirring Methods 0.000 description 11
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108010076504 Protein Sorting Signals Proteins 0.000 description 10
GYDFRTRSSXOZCR-ACZMJKKPSA-N Ser-Ser-Glu Chemical compound OC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@H](C(O)=O)CCC(O)=O GYDFRTRSSXOZCR-ACZMJKKPSA-N 0.000 description 10
YBXMGKCLOPDEKA-NUMRIWBASA-N Thr-Asp-Glu Chemical compound [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O YBXMGKCLOPDEKA-NUMRIWBASA-N 0.000 description 10
QHDXUYOYTPWCSK-RCOVLWMOSA-N Val-Asp-Gly Chemical compound CC(C)[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)O)N QHDXUYOYTPWCSK-RCOVLWMOSA-N 0.000 description 10
108010062796 arginyllysine Proteins 0.000 description 10
108010092854 aspartyllysine Proteins 0.000 description 10
108010054155 lysyllysine Proteins 0.000 description 10
239000008188 pellet Substances 0.000 description 10
108040007629 peroxidase activity proteins Proteins 0.000 description 10
239000011347 resin Substances 0.000 description 10
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108010048397 seryl-lysyl-leucine Proteins 0.000 description 10
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NVFSJIXJZCDICF-SRVKXCTJSA-N Asp-Lys-Lys Chemical compound C(CCN)C[C@@H](C(=O)N[C@@H](CCCCN)C(=O)O)NC(=O)[C@H](CC(=O)O)N NVFSJIXJZCDICF-SRVKXCTJSA-N 0.000 description 9
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 9
241000588724 Escherichia coli Species 0.000 description 9
FFJQHWKSGAWSTJ-BFHQHQDPSA-N Gly-Thr-Ala Chemical compound [H]NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(O)=O FFJQHWKSGAWSTJ-BFHQHQDPSA-N 0.000 description 9
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108010033576 Transferrin Receptors Proteins 0.000 description 9
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108010015792 glycyllysine Proteins 0.000 description 9
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RTZCUEHYUQZIDE-WHFBIAKZSA-N Ala-Ser-Gly Chemical compound C[C@H](N)C(=O)N[C@@H](CO)C(=O)NCC(O)=O RTZCUEHYUQZIDE-WHFBIAKZSA-N 0.000 description 8
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