HUP9801714A2 - Neisseria meningitidis TBP2 alegység - Google Patents
Neisseria meningitidis TBP2 alegységInfo
- Publication number
- HUP9801714A2 HUP9801714A2 HU9801714A HUP9801714A HUP9801714A2 HU P9801714 A2 HUP9801714 A2 HU P9801714A2 HU 9801714 A HU9801714 A HU 9801714A HU P9801714 A HUP9801714 A HU P9801714A HU P9801714 A2 HUP9801714 A2 HU P9801714A2
- Authority
- HU
- Hungary
- Prior art keywords
- tbp2
- subunit
- meningitidis
- strain
- hinge region
- Prior art date
Links
- 101150101515 tbpl2 gene Proteins 0.000 title abstract 8
- 241000588650 Neisseria meningitidis Species 0.000 title abstract 4
- 101100245206 Dictyostelium discoideum psmC4 gene Proteins 0.000 title 1
- 101150080060 TBP2 gene Proteins 0.000 title 1
- 101150095556 tbpB gene Proteins 0.000 title 1
- 239000012634 fragment Substances 0.000 abstract 3
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 102000007238 Transferrin Receptors Human genes 0.000 abstract 1
- 108010033576 Transferrin Receptors Proteins 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 102000005962 receptors Human genes 0.000 abstract 1
- 108020003175 receptors Proteins 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
A találmány tárgya egy lényegében tisztítőtt fehérje, azaz egy N.meningitidis törzs hűmán transzferrin receptőrának (HTR) kismőlekűlatömegű alegysége (Tbp2), ahől a törzset az jellemzi, hőgy dőt-blőt vizsgálatban nem ismeri fel az N. meningitidis M982 törzs Tbp2alegységének megfelelő pőlipeptid (M982 Tbp2) - amelyből a másődikdőmén (hinge régió) hipervariábilis részeit deletálták - ellen kapőttantiszérűm. A Tbp2 alegységet az jellemzi, hőgy (i) egy kb. 2,1 kbDNS-fragmens kódőlja és (ii) az tartalmaz egy M982-típűsú hingerégiót. Az említett Tbp2 alegység és az ebből származó pőlipeptidfragmensek felhasználhatók vakcinaként, előnyösen az ismert N.meningitidis Tbp2 alegységekkel kőmbinálva. A találmány az új Tbp2-tés az ebből származó pőlipeptideket kódőló DNS-fragmensekre isvőnatkőzik. ŕ
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9512106A FR2739624B1 (fr) | 1995-10-10 | 1995-10-10 | Nouvelle sous-unite tbp2 de neisseria meningitidis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP9801714A2 true HUP9801714A2 (hu) | 1998-10-28 |
| HUP9801714A3 HUP9801714A3 (en) | 2000-03-28 |
Family
ID=9483560
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9801714A HUP9801714A3 (en) | 1995-10-10 | 1996-10-10 | Neisseria meningitidis subunit tbp2 |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0796332A1 (hu) |
| JP (1) | JPH11500630A (hu) |
| CA (1) | CA2207302A1 (hu) |
| FR (1) | FR2739624B1 (hu) |
| HU (1) | HUP9801714A3 (hu) |
| NO (1) | NO972314L (hu) |
| WO (1) | WO1997013860A1 (hu) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2767060B1 (fr) * | 1997-08-07 | 2000-02-11 | Pasteur Merieux Serums Vacc | Vaccin meningocoque comportant la valence de souche bz83 |
| JP5102414B2 (ja) | 1998-05-01 | 2012-12-19 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | 髄膜炎菌抗原および組成物 |
| AU2012203235B2 (en) * | 1998-05-01 | 2014-04-24 | Glaxosmithkline Biologicals Sa | Neisseria meningitidis antigens and compositions |
| GB9902084D0 (en) * | 1999-01-29 | 1999-03-24 | Smithkline Beecham Biolog | Novel compounds |
| CN100392082C (zh) | 1999-04-30 | 2008-06-04 | 启龙股份公司 | 保守的奈瑟球菌抗原 |
| DK2270173T3 (en) | 1999-05-19 | 2016-03-07 | Glaxosmithkline Biolog Sa | Neisserial combination compositions |
| GB9928196D0 (en) | 1999-11-29 | 2000-01-26 | Chiron Spa | Combinations of B, C and other antigens |
| MXPA02008314A (es) * | 2000-02-28 | 2002-12-09 | Chiron Spa | Expresion heterologa de proteinas de neisseria. |
| GB0121591D0 (en) | 2001-09-06 | 2001-10-24 | Chiron Spa | Hybrid and tandem expression of neisserial proteins |
| CA2501812C (en) | 2002-10-11 | 2012-07-10 | Mariagrazia Pizza | Polypeptide-vaccines for broad protection against hypervirulent meningococcal lineages |
| GB0408977D0 (en) | 2004-04-22 | 2004-05-26 | Chiron Srl | Immunising against meningococcal serogroup Y using proteins |
| CA2810971C (en) | 2010-09-10 | 2020-11-03 | Novartis Ag | Developments in meningococcal outer membrane vesicles |
| WO2013186753A1 (en) | 2012-06-14 | 2013-12-19 | Novartis Ag | Vaccines for serogroup x meningococcus |
| WO2016091902A1 (en) * | 2014-12-09 | 2016-06-16 | Sanofi Pasteur | Compositions comprising n. meningitidis proteins |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2682041B1 (fr) * | 1991-10-03 | 1994-01-14 | Pasteur Merieux Serums Vaccins | Vaccin contre les infections a neisseria meningitidis. |
| FR2692592B1 (fr) * | 1992-06-19 | 1995-03-31 | Pasteur Merieux Serums Vacc | Fragments d'ADN codant pour les sous-unités du récepteur de la transferrine de Neisseria meningitidis et procédés les exprimant. |
| FR2720408B1 (fr) * | 1994-05-31 | 1996-08-14 | Pasteur Merieux Serums Vacc | Fragments Tbp2 de Neisseria meningitidis. |
-
1995
- 1995-10-10 FR FR9512106A patent/FR2739624B1/fr not_active Expired - Fee Related
-
1996
- 1996-10-10 CA CA002207302A patent/CA2207302A1/en not_active Abandoned
- 1996-10-10 WO PCT/FR1996/001580 patent/WO1997013860A1/fr not_active Application Discontinuation
- 1996-10-10 HU HU9801714A patent/HUP9801714A3/hu unknown
- 1996-10-10 JP JP9514773A patent/JPH11500630A/ja active Pending
- 1996-10-10 EP EP96933511A patent/EP0796332A1/fr not_active Withdrawn
-
1997
- 1997-05-21 NO NO972314A patent/NO972314L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO1997013860A1 (fr) | 1997-04-17 |
| CA2207302A1 (en) | 1997-04-17 |
| NO972314L (no) | 1997-07-18 |
| HUP9801714A3 (en) | 2000-03-28 |
| AU7221396A (en) | 1997-04-30 |
| FR2739624A1 (fr) | 1997-04-11 |
| NO972314D0 (no) | 1997-05-21 |
| FR2739624B1 (fr) | 1997-12-05 |
| JPH11500630A (ja) | 1999-01-19 |
| EP0796332A1 (fr) | 1997-09-24 |
| AU720789B2 (en) | 2000-06-15 |
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