CA2207302A1 - Sous-unite tbp2 de neisseria meningitidis - Google Patents

Sous-unite tbp2 de neisseria meningitidis

Info

Publication number
CA2207302A1
CA2207302A1 CA002207302A CA2207302A CA2207302A1 CA 2207302 A1 CA2207302 A1 CA 2207302A1 CA 002207302 A CA002207302 A CA 002207302A CA 2207302 A CA2207302 A CA 2207302A CA 2207302 A1 CA2207302 A1 CA 2207302A1
Authority
CA
Canada
Prior art keywords
tbp2
gly
ala
thr
lys
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002207302A
Other languages
English (en)
Inventor
Marie-Jose Quentin-Millet
Bachra Rokbi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Pasteur SA
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2207302A1 publication Critical patent/CA2207302A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

L'invention a pour objet une protéine sous forme substantiellement purifiée, qui est la sous-unité de moindre poids moléculaire (Tbp2) du récepteur de la transferrine humaine (RTH) d'une souche de N. meningitidis; la souche étant caractérisée en ce qu'elle n'est pas reconnue en dot blot par un antisérum obtenu à l'encontre d'un polypeptide correspondant à la Tbp2 de la souche N. meningitidis M982 (Tbp2 M982) délétée des portions hypervariables du deuxième domaine; et la sous-unité Tbp2 étant caractérisée (i) en ce qu'elle est codée par un fragment d'ADN d'environ 2,1 kb et (ii) en ce qu'elle possède une région charnière de type M982. Cette sous-unité Tbp2 ainsi que les fragments polypeptidiques qui en sont dérivés sont notamment utiles à des fins vaccinales, plus particulièrement en association avec des sous-unités Tbp2 de N. meningitidis déjà connues. L'invention fournit également des fragments d'ADN codant pour ces nouvelles Tbp2 et polypeptides dérivés.
CA002207302A 1995-10-10 1996-10-10 Sous-unite tbp2 de neisseria meningitidis Abandoned CA2207302A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR95/12106 1995-10-10
FR9512106A FR2739624B1 (fr) 1995-10-10 1995-10-10 Nouvelle sous-unite tbp2 de neisseria meningitidis

Publications (1)

Publication Number Publication Date
CA2207302A1 true CA2207302A1 (fr) 1997-04-17

Family

ID=9483560

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002207302A Abandoned CA2207302A1 (fr) 1995-10-10 1996-10-10 Sous-unite tbp2 de neisseria meningitidis

Country Status (7)

Country Link
EP (1) EP0796332A1 (fr)
JP (1) JPH11500630A (fr)
CA (1) CA2207302A1 (fr)
FR (1) FR2739624B1 (fr)
HU (1) HUP9801714A3 (fr)
NO (1) NO972314L (fr)
WO (1) WO1997013860A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10232029B2 (en) 2014-12-09 2019-03-19 Sanofi Pasteur Compositions comprising N. meningitidis proteins

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2767060B1 (fr) * 1997-08-07 2000-02-11 Pasteur Merieux Serums Vacc Vaccin meningocoque comportant la valence de souche bz83
NZ541361A (en) 1998-05-01 2008-04-30 Inst Genomic Research Neisseria meningitidis antigens and compositions relating to SEQ ID Nos:2916, 2918 and 2920
AU2012203235B2 (en) * 1998-05-01 2014-04-24 Glaxosmithkline Biologicals Sa Neisseria meningitidis antigens and compositions
GB9902084D0 (en) * 1999-01-29 1999-03-24 Smithkline Beecham Biolog Novel compounds
MXPA01010924A (es) 1999-04-30 2002-05-06 Chiron Spa Antigenos de neisseria conservados.
NZ545647A (en) 1999-05-19 2008-02-29 Chiron Srl Combination neisserial compositions
GB9928196D0 (en) 1999-11-29 2000-01-26 Chiron Spa Combinations of B, C and other antigens
BR0108711A (pt) * 2000-02-28 2004-06-22 Chiron Spa Expressão heteróloga de proteìnas de neisseria
GB0121591D0 (en) 2001-09-06 2001-10-24 Chiron Spa Hybrid and tandem expression of neisserial proteins
SI1549338T1 (sl) 2002-10-11 2011-04-29 Novartis Vaccines & Diagnostic Polipeptidna cepiva za ĺ iroko zaĺ äśito pred hipervirulentnimi miningokoknimi rodovi
GB0408977D0 (en) 2004-04-22 2004-05-26 Chiron Srl Immunising against meningococcal serogroup Y using proteins
BR112013005626B1 (pt) 2010-09-10 2022-07-26 Glaxosmithkline Biologicals Sa Meningococo, processo para a preparação de uma cepa meningocócica, vesículas de membrana externa, composição farmacêutica imunogênica, e, uso de uma composição
CA2876138C (fr) 2012-06-14 2023-09-19 Novartis Ag Vaccins contre le meningocoque de serogroupe x

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2682041B1 (fr) * 1991-10-03 1994-01-14 Pasteur Merieux Serums Vaccins Vaccin contre les infections a neisseria meningitidis.
FR2692592B1 (fr) * 1992-06-19 1995-03-31 Pasteur Merieux Serums Vacc Fragments d'ADN codant pour les sous-unités du récepteur de la transferrine de Neisseria meningitidis et procédés les exprimant.
FR2720408B1 (fr) * 1994-05-31 1996-08-14 Pasteur Merieux Serums Vacc Fragments Tbp2 de Neisseria meningitidis.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10232029B2 (en) 2014-12-09 2019-03-19 Sanofi Pasteur Compositions comprising N. meningitidis proteins

Also Published As

Publication number Publication date
JPH11500630A (ja) 1999-01-19
EP0796332A1 (fr) 1997-09-24
AU720789B2 (en) 2000-06-15
FR2739624A1 (fr) 1997-04-11
HUP9801714A3 (en) 2000-03-28
FR2739624B1 (fr) 1997-12-05
HUP9801714A2 (hu) 1998-10-28
NO972314L (no) 1997-07-18
AU7221396A (en) 1997-04-30
WO1997013860A1 (fr) 1997-04-17
NO972314D0 (no) 1997-05-21

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued