CA2201721A1 - Microorganisms as therapeutic delivery systems - Google Patents
Microorganisms as therapeutic delivery systemsInfo
- Publication number
- CA2201721A1 CA2201721A1 CA002201721A CA2201721A CA2201721A1 CA 2201721 A1 CA2201721 A1 CA 2201721A1 CA 002201721 A CA002201721 A CA 002201721A CA 2201721 A CA2201721 A CA 2201721A CA 2201721 A1 CA2201721 A1 CA 2201721A1
- Authority
- CA
- Canada
- Prior art keywords
- lra
- protein
- bacteria
- administration
- pct
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- 230000002537 thrombolytic effect Effects 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- 230000010415 tropism Effects 0.000 description 1
- 241001529453 unidentified herpesvirus Species 0.000 description 1
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
- 229960005356 urokinase Drugs 0.000 description 1
- 230000009105 vegetative growth Effects 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- DGVVWUTYPXICAM-UHFFFAOYSA-N β‐Mercaptoethanol Chemical compound OCCS DGVVWUTYPXICAM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/746—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for lactic acid bacteria (Streptococcus; Lactococcus; Lactobacillus; Pediococcus; Enterococcus; Leuconostoc; Propionibacterium; Bifidobacterium; Sporolactobacillus)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/75—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Bacillus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI94A002025 | 1994-10-05 | ||
| ITMI942025A IT1270123B (it) | 1994-10-05 | 1994-10-05 | Composizioni farmaceutiche contenenti microorganismi ingegnerizzati e loro uso per terapia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2201721A1 true CA2201721A1 (en) | 1996-04-18 |
Family
ID=11369649
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002201721A Abandoned CA2201721A1 (en) | 1994-10-05 | 1995-10-04 | Microorganisms as therapeutic delivery systems |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0784689A1 (it) |
| JP (1) | JPH10506791A (it) |
| AU (1) | AU3745395A (it) |
| CA (1) | CA2201721A1 (it) |
| IT (1) | IT1270123B (it) |
| WO (1) | WO1996011277A1 (it) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6190657B1 (en) | 1995-06-07 | 2001-02-20 | Yale University | Vectors for the diagnosis and treatment of solid tumors including melanoma |
| GB9521568D0 (en) * | 1995-10-20 | 1995-12-20 | Lynxvale Ltd | Delivery of biologically active polypeptides |
| US6080849A (en) * | 1997-09-10 | 2000-06-27 | Vion Pharmaceuticals, Inc. | Genetically modified tumor-targeted bacteria with reduced virulence |
| AU749695B2 (en) | 1997-09-10 | 2002-07-04 | Vion Pharmaceuticals, Inc. | Genetically modified tumor-targeted bacteria with reduced virulence |
| DE69914932T2 (de) * | 1998-10-20 | 2004-12-09 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. | Verwendung eines zytokine-produzierenden lactococcus stammes zur behandlung von kolitis |
| FR2791998B1 (fr) * | 1999-04-07 | 2001-06-08 | Agronomique Inst Nat Rech | Lactocoques modifies exprimant une catalase et leurs utilisations |
| DK1739178T3 (da) * | 1999-07-05 | 2010-11-22 | Actogenix Nv | Levering af trekløverpeptider |
| US6962696B1 (en) | 1999-10-04 | 2005-11-08 | Vion Pharmaceuticals Inc. | Compositions and methods for tumor-targeted delivery of effector molecules |
| ATE381351T1 (de) * | 2000-07-27 | 2008-01-15 | Univ Pennsylvania | Anwendung des herpes simplex virus glykoproteins- d zur unterdrückung von immunantworten |
| CA2342040C (en) | 2000-09-21 | 2012-07-10 | Kyowa Hakko Kogyo Co., Ltd. | Anaerobic bacterium as a drug for cancer gene therapy |
| US7780961B2 (en) | 2001-05-03 | 2010-08-24 | Actogenix N.V. | Self-containing Lactococcus strain |
| WO2003063786A2 (en) * | 2002-01-31 | 2003-08-07 | Symbigene, Inc. | Methods and composition for delivering nucleic acids and/or proteins to the respiratory system |
| WO2004007695A2 (en) * | 2002-03-08 | 2004-01-22 | Osel, Inc. | Lactobacilli expressing biologically active polypeptides and uses thereof |
| EP1513545B1 (en) * | 2002-06-19 | 2008-03-19 | Actogenix N.V. | Methods and means to promote gut absorption |
| EP1590443A4 (en) * | 2003-01-29 | 2009-01-07 | Osel Inc | SURFACE EXPRESSION OF BIOLOGICALLY ACTIVE PROTEINS IN BACTERIA |
| EP1786445B1 (en) | 2004-08-25 | 2011-06-08 | The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services | Live microbial microbicides |
| CA2579882C (en) | 2004-09-10 | 2012-07-17 | Asahi Glass Company, Limited | Edible vaccine |
| US7456011B2 (en) | 2005-01-12 | 2008-11-25 | Osel, Inc. | Modified cyanovirin-n polypeptide |
| EP1957100B1 (en) | 2005-11-29 | 2016-07-13 | Intrexon Actobiotics NV | Induction of mucosal tolerance to antigens |
| BRPI0711119A2 (pt) * | 2006-05-02 | 2011-08-30 | Actogenix Nv | administração microbiana de peptìdeos intestinais associados à obesidade |
| AU2008204442B2 (en) | 2007-01-12 | 2013-03-14 | Intrexon Actobiotics Nv | Lactococcus promoters and uses thereof |
| EP2125010B1 (en) | 2007-01-25 | 2014-06-04 | Actogenix N.V. | Treatment of immune disease by mucosal delivery of antigens using genetically modified lactobacillus |
| JP2012504116A (ja) | 2008-09-29 | 2012-02-16 | アクトジェニックス・エヌブイ | 粘膜での微生物のコロニー形成の低減 |
| DK2424972T3 (da) | 2009-04-30 | 2013-10-14 | Actogenix Nv | Kryobeskyttende midler til frysetørring af mælkesyrebakterier |
| EP3192873A1 (en) | 2009-09-29 | 2017-07-19 | Intrexon Actobiotics NV | Lactobacillus and streptococcus promoters and uses thereof |
| EP2451467B1 (en) * | 2010-01-14 | 2016-12-21 | INSERM - Institut National de la Santé et de la Recherche Médicale | Recombinant probiotic bacteria for the prevention and treatment of inflammatory bowel disease (ibd) and irritable bowel syndrome (ibs) |
| US9597379B1 (en) | 2010-02-09 | 2017-03-21 | David Gordon Bermudes | Protease inhibitor combination with therapeutic proteins including antibodies |
| FR2960001A1 (fr) * | 2010-05-12 | 2011-11-18 | Univ Rennes | Vecteur recombinant pour la production et la secretion de sequences d'acides amines d'interet par les bacteries propioniques et ses applications |
| US9476056B2 (en) | 2010-05-12 | 2016-10-25 | Universite De Rennes 1 | Recombinant vector for producing and secreting peptide or protein of interest by propionibacteria and applications thereof |
| AU2011268146A1 (en) | 2010-06-17 | 2013-01-10 | Actogenix Nv | Compositions and methods for treating inflammatory conditions |
| CN101921725B (zh) * | 2010-07-27 | 2013-06-05 | 浙江大学 | 一种口服免疫阻断鸡生长抑素作用的转化子及其应用 |
| ES2676707T3 (es) | 2011-09-23 | 2018-07-24 | Intrexon Actobiotics Nv | Bacterias gram positivas modificadas y usos de las mismas |
| HUE038336T2 (hu) | 2011-09-23 | 2018-10-29 | Intrexon Actobiotics Nv | Módosított gram-pozitív baktériumok és alkalmazásaik |
| AU2013299605A1 (en) | 2012-08-07 | 2015-03-26 | TopGeniX, Inc. | Topical composition comprising transformed bacteria expressing a compound of interest |
| US10064797B2 (en) | 2014-06-17 | 2018-09-04 | TopGeniX, Inc. | Topical formulations for UV protection |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| HRP20240085T1 (hr) | 2019-03-04 | 2024-03-29 | Aurealis Therapeutics AG | Prokariotski ekspresijski sustav indukciran kloridom |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1321962C (en) * | 1985-03-20 | 1993-09-07 | Aizo Matsushiro | Dental caries preventive preparations and method for preparing said preparations |
-
1994
- 1994-10-05 IT ITMI942025A patent/IT1270123B/it active IP Right Grant
-
1995
- 1995-10-04 EP EP95935431A patent/EP0784689A1/en not_active Withdrawn
- 1995-10-04 CA CA002201721A patent/CA2201721A1/en not_active Abandoned
- 1995-10-04 JP JP8512318A patent/JPH10506791A/ja active Pending
- 1995-10-04 WO PCT/EP1995/003921 patent/WO1996011277A1/en not_active Application Discontinuation
- 1995-10-04 AU AU37453/95A patent/AU3745395A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ITMI942025A1 (it) | 1996-04-05 |
| JPH10506791A (ja) | 1998-07-07 |
| AU3745395A (en) | 1996-05-02 |
| IT1270123B (it) | 1997-04-28 |
| EP0784689A1 (en) | 1997-07-23 |
| WO1996011277A1 (en) | 1996-04-18 |
| ITMI942025A0 (it) | 1994-10-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |