AU3745395A - Microorganisms as therapeutic delivery systems - Google Patents

Microorganisms as therapeutic delivery systems

Info

Publication number
AU3745395A
AU3745395A AU37453/95A AU3745395A AU3745395A AU 3745395 A AU3745395 A AU 3745395A AU 37453/95 A AU37453/95 A AU 37453/95A AU 3745395 A AU3745395 A AU 3745395A AU 3745395 A AU3745395 A AU 3745395A
Authority
AU
Australia
Prior art keywords
microorganisms
delivery systems
therapeutic delivery
therapeutic
systems
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU37453/95A
Inventor
Diana Boraschi
Paola Bossu'
Giovanni Macchia
Giovanni Maurizi
Stefano Porzio
Paolo Ruggiero
Aldo Tagliabue
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dompe SpA
Original Assignee
Dompe SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dompe SpA filed Critical Dompe SpA
Publication of AU3745395A publication Critical patent/AU3745395A/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/746—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for lactic acid bacteria (Streptococcus; Lactococcus; Lactobacillus; Pediococcus; Enterococcus; Leuconostoc; Propionibacterium; Bifidobacterium; Sporolactobacillus)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/75—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Bacillus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU37453/95A 1994-10-05 1995-10-04 Microorganisms as therapeutic delivery systems Abandoned AU3745395A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI94A2025 1994-10-05
ITMI942025A IT1270123B (en) 1994-10-05 1994-10-05 PHARMACEUTICAL COMPOSITIONS CONTAINING ENGINEERED MICROORGANISMS AND THEIR USE FOR THERAPY
PCT/EP1995/003921 WO1996011277A1 (en) 1994-10-05 1995-10-04 Microorganisms as therapeutic delivery systems

Publications (1)

Publication Number Publication Date
AU3745395A true AU3745395A (en) 1996-05-02

Family

ID=11369649

Family Applications (1)

Application Number Title Priority Date Filing Date
AU37453/95A Abandoned AU3745395A (en) 1994-10-05 1995-10-04 Microorganisms as therapeutic delivery systems

Country Status (6)

Country Link
EP (1) EP0784689A1 (en)
JP (1) JPH10506791A (en)
AU (1) AU3745395A (en)
CA (1) CA2201721A1 (en)
IT (1) IT1270123B (en)
WO (1) WO1996011277A1 (en)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6190657B1 (en) 1995-06-07 2001-02-20 Yale University Vectors for the diagnosis and treatment of solid tumors including melanoma
GB9521568D0 (en) * 1995-10-20 1995-12-20 Lynxvale Ltd Delivery of biologically active polypeptides
US6080849A (en) 1997-09-10 2000-06-27 Vion Pharmaceuticals, Inc. Genetically modified tumor-targeted bacteria with reduced virulence
EP1012232B1 (en) 1997-09-10 2009-10-28 Vion Pharmaceuticals, Inc. Genetically modified tumor-targeted bacteria with reduced virulence
DE69914932T2 (en) * 1998-10-20 2004-12-09 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. USE OF A CYTOKINE-PRODUCING LACTOCOCCUS TRIBE FOR TREATING COLUMN
FR2791998B1 (en) * 1999-04-07 2001-06-08 Agronomique Inst Nat Rech MODIFIED LACTOCOCCUS EXPRESSING CATALASE AND USES THEREOF
US7220418B1 (en) * 1999-07-05 2007-05-22 Vlaams Interuniversitair Instituut Voor Biotechnologie Delivery of trefoil peptides
US6962696B1 (en) 1999-10-04 2005-11-08 Vion Pharmaceuticals Inc. Compositions and methods for tumor-targeted delivery of effector molecules
AU8467201A (en) * 2000-07-27 2002-02-13 Univ Pennsylvania Compositions for and methods of using herpes simplex virus glycoprotein d to suppress immune responses
CA2342040C (en) 2000-09-21 2012-07-10 Kyowa Hakko Kogyo Co., Ltd. Anaerobic bacterium as a drug for cancer gene therapy
US7780961B2 (en) 2001-05-03 2010-08-24 Actogenix N.V. Self-containing Lactococcus strain
AU2003210688A1 (en) * 2002-01-31 2003-09-02 Symbigene, Inc. Methods and composition for delivering nucleic acids and/or proteins to the respiratory system
US7179458B2 (en) 2002-03-08 2007-02-20 Osel, Inc. Lactobacilli expressing biologically active polypeptides and uses thereof
JP2005529622A (en) * 2002-06-19 2005-10-06 ヴェーイーベー・ヴェーゼットウェー Methods and means for promoting intestinal absorption
JP2007503845A (en) * 2003-01-29 2007-03-01 オセル， インコーポレイテッド Surface expression of biologically active proteins in bacteria
ATE511848T1 (en) 2004-08-25 2011-06-15 Us Gov Health & Human Serv LIVE MICROBIAL MICROBICIDES
KR101187625B1 (en) 2004-09-10 2012-10-05 도쿠리츠다이가쿠호징 가나자와다이가쿠 Vaccine for oral administration
US7456011B2 (en) 2005-01-12 2008-11-25 Osel, Inc. Modified cyanovirin-n polypeptide
DK2119450T3 (en) 2005-11-29 2013-05-06 Actogenix Nv Induction of mucosal tolerance to pancreatic islet beta cell autoantigens
US20090074734A1 (en) * 2006-05-02 2009-03-19 Actogenix N.V. Microbial intestinal delivery of obesity related peptides
ES2595729T3 (en) 2007-01-12 2017-01-03 Intrexon Actobiotics Nv Lactococcus promoters and their uses
ES2492468T3 (en) 2007-01-25 2014-09-09 Actogenix N.V. Treatment of immune disease by administration through the antigen mucosa using genetically modified Lactobacillus
EP3181682B1 (en) 2008-09-29 2021-04-21 Intrexon Actobiotics NV Reduced colonization of microbes at the mucosa
DK2424972T3 (en) 2009-04-30 2013-10-14 Actogenix Nv Cryoprotectants for freeze-drying of lactic acid bacteria
WO2011039137A1 (en) 2009-09-29 2011-04-07 Actogenix N.V. Lactobacillus and streptococcus promoters and uses thereof
AU2011206532B8 (en) 2010-01-14 2015-08-06 Inserm (Institut National De La Sante Et De La Recherche Medicale) Recombinant probiotic bacteria for the prevention and treatment of inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS)
US9597379B1 (en) 2010-02-09 2017-03-21 David Gordon Bermudes Protease inhibitor combination with therapeutic proteins including antibodies
FR2960001A1 (en) * 2010-05-12 2011-11-18 Univ Rennes RECOMBINANT VECTOR FOR THE PRODUCTION AND SECRETION OF AMINO ACID SEQUENCES OF INTEREST BY PROPIONIC BACTERIA AND ITS APPLICATIONS
US9476056B2 (en) 2010-05-12 2016-10-25 Universite De Rennes 1 Recombinant vector for producing and secreting peptide or protein of interest by propionibacteria and applications thereof
US20130164380A1 (en) 2010-06-17 2013-06-27 Actogenix Nv Compositions and methods for treating inflammatory conditions
CN101921725B (en) * 2010-07-27 2013-06-05 浙江大学 Converter for inhibiting hen somatostatin action through oral immunization and application thereof
CN103917639B (en) 2011-09-23 2017-09-26 英特瑞克斯顿阿克图比奥帝克斯有限公司 Gram-positive bacterium through modification and application thereof
EP2758512B1 (en) 2011-09-23 2018-05-09 Intrexon Actobiotics NV Modified gram positive bacteria and uses thereof
WO2014025938A1 (en) 2012-08-07 2014-02-13 TopGeniX, Inc. Topical composition comprising transformed bacteria expressing a compound of interest
US10064797B2 (en) 2014-06-17 2018-09-04 TopGeniX, Inc. Topical formulations for UV protection
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
KR102602358B1 (en) 2019-03-04 2023-11-17 아우리얼리스 테라퓨틱스 아게 Chloride-inducible prokaryotic expression system

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1321962C (en) * 1985-03-20 1993-09-07 Aizo Matsushiro Dental caries preventive preparations and method for preparing said preparations

Also Published As

Publication number Publication date
WO1996011277A1 (en) 1996-04-18
EP0784689A1 (en) 1997-07-23
IT1270123B (en) 1997-04-28
ITMI942025A0 (en) 1994-10-05
JPH10506791A (en) 1998-07-07
ITMI942025A1 (en) 1996-04-05
CA2201721A1 (en) 1996-04-18

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