CA2183952C - Produit ou comprime granulaire contenant un systeme effervescent et un principe actif pharmaceutique, et son procede de preparation - Google Patents

Produit ou comprime granulaire contenant un systeme effervescent et un principe actif pharmaceutique, et son procede de preparation Download PDF

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Publication number
CA2183952C
CA2183952C CA002183952A CA2183952A CA2183952C CA 2183952 C CA2183952 C CA 2183952C CA 002183952 A CA002183952 A CA 002183952A CA 2183952 A CA2183952 A CA 2183952A CA 2183952 C CA2183952 C CA 2183952C
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CA
Canada
Prior art keywords
weight
acid
granular product
tablet
effervescent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002183952A
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English (en)
Other versions
CA2183952A1 (fr
Inventor
Thomas Gergely
Stefan Gergely
Gerhard Gergely
Irmgard Gergely
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
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Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP94203112A external-priority patent/EP0670160B1/fr
Application filed by Individual filed Critical Individual
Publication of CA2183952A1 publication Critical patent/CA2183952A1/fr
Application granted granted Critical
Publication of CA2183952C publication Critical patent/CA2183952C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007—Effervescent

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  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne un produit granulaire à système effervescent comprenant des principes actifs pharmaceutiques sensibles à l'acide tels que, par exemple, le bêta-carotène, la cimétidine, la ranitidine ou le cisapride. Ce produit est particulièrement utile pour prévenir l'action antiacide, présentant une capacité de fixation de l'acide inférieure à 5 meq, à un poids d'environ 1,6 à 2,3 grammes. Les grains effervescents sont constitués de cristaux véhiculeurs comprenant au moins un acide organique solide comestible, de préférence de l'acide citrique, se présentent sous forme de produit granulaire, séparés du principe actif pharmaceutique, et sont enrobés d'au moins une couche de substance neutre soluble dans l'eau et/ou d'alcool capable de provoquer une chute du point de fusion des grains d'acide à leur surface, comme, par exemple, un polymère soluble dans l'eau, un alcool supérieur, un hydrate de carbone et/ou un hydrocolloïde. Une seconde couche contient au moins une partie de l'alcali et/ou du carbonate alcalino-terreux prévu pour le dosage total.
CA002183952A 1994-03-01 1995-02-23 Produit ou comprime granulaire contenant un systeme effervescent et un principe actif pharmaceutique, et son procede de preparation Expired - Fee Related CA2183952C (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
DEP4406641.4 1994-03-01
DE4406641 1994-03-01
CH87394 1994-03-23
CH873/94-6 1994-03-23
EP94203112.1 1994-10-26
EP94203112A EP0670160B1 (fr) 1994-03-01 1994-10-26 Produit granulaire ou comprimé contenant un système effervescent et un agent actif pharmaceutique, et son procédé de préparation
PCT/EP1995/000650 WO1995023594A1 (fr) 1994-03-01 1995-02-23 Produit ou comprime granulaire contenant un systeme effervescent et un principe actif pharmaceutique, et son procede de preparation

Publications (2)

Publication Number Publication Date
CA2183952A1 CA2183952A1 (fr) 1995-09-08
CA2183952C true CA2183952C (fr) 2007-01-16

Family

ID=27172490

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002183952A Expired - Fee Related CA2183952C (fr) 1994-03-01 1995-02-23 Produit ou comprime granulaire contenant un systeme effervescent et un principe actif pharmaceutique, et son procede de preparation

Country Status (15)

Country Link
JP (1) JPH09509669A (fr)
CN (1) CN1213739C (fr)
AU (1) AU681256B2 (fr)
BR (1) BR9506964A (fr)
CA (1) CA2183952C (fr)
CZ (1) CZ291710B6 (fr)
DE (1) DE670160T1 (fr)
FI (1) FI118033B (fr)
HU (1) HU228147B1 (fr)
NO (1) NO315308B1 (fr)
NZ (1) NZ281228A (fr)
PL (1) PL181714B1 (fr)
RU (1) RU2153331C2 (fr)
TW (1) TW403658B (fr)
WO (1) WO1995023594A1 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US6489346B1 (en) 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US20030070584A1 (en) 2001-05-15 2003-04-17 Cynthia Gulian Dip coating compositions containing cellulose ethers
US8309118B2 (en) 2001-09-28 2012-11-13 Mcneil-Ppc, Inc. Film forming compositions containing sucralose
DE10224607B4 (de) * 2002-06-04 2008-03-13 Lts Lohmann Therapie-Systeme Ag Filmförmige, zerfallsfähige Zubereitungen zur Wirkstofffreisetzung und Verfahren zu deren Herstellung
AU2002350719A1 (en) * 2002-11-29 2004-06-23 Janssen Pharmaceutica N.V. Pharmaceutical compositions comprising a basic respectively acidic drug compound, a surfactant and a physiologically tolerable water-soluble acid respectively base
US8993599B2 (en) 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en) 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
WO2006059716A1 (fr) * 2004-12-03 2006-06-08 Takeda Pharmaceutical Company Limited Preparation solide
CA2785694C (fr) 2010-02-26 2013-12-17 Toray Industries, Inc. Preparation solide enrobee
EP2788289B1 (fr) * 2011-12-09 2019-07-31 Merck Patent GmbH Carbonate de sodium anhydre faiblement poreux
US20150289554A1 (en) * 2012-10-25 2015-10-15 Otc Nutrition Llc Fast Dissolving Solid Calcium Mineral Supplement Compositions and Processing Making
MX2015007640A (es) 2012-12-19 2015-09-23 Bayer Animal Health Gmbh Comprimidos que tienen aceptacion mejorada y buena estabilidad durante el almacenamiento.
CN105670003A (zh) * 2014-11-21 2016-06-15 常州坤宇环保科技有限公司 高吸水树脂防结块剂
EP3318135A1 (fr) * 2016-11-03 2018-05-09 Perfetti Van Melle S.p.A. Matériau de bonbon effervescent, son procédé de préparation et produits fabriqués à partir de celui-ci
JP2022553004A (ja) * 2019-10-17 2022-12-21 アイエスピー インヴェストメンツ エルエルシー 安定発泡性共処理賦形剤組成物およびその調製方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1039170A (en) * 1969-02-24 1971-07-22 Abbott Laboratories Tableting medium
US4704269A (en) * 1985-06-11 1987-11-03 Hudson Pharmaceutical Corporation Effervescent antacid and analgesic compositions
CA2023493C (fr) * 1989-08-31 2000-01-04 Masami Moroi Melange servant a l'administration d'un produit moussant
DE59201238D1 (de) * 1991-07-01 1995-03-02 Gerhard Gergely Reaktionsdotierte brausesysteme.

Also Published As

Publication number Publication date
WO1995023594A1 (fr) 1995-09-08
HU228147B1 (en) 2012-12-28
CZ291710B6 (cs) 2003-05-14
PL316113A1 (en) 1996-12-23
HU9602380D0 (en) 1996-10-28
TW403658B (en) 2000-09-01
CN1142182A (zh) 1997-02-05
BR9506964A (pt) 1997-09-09
CN1213739C (zh) 2005-08-10
AU1811495A (en) 1995-09-18
RU2153331C2 (ru) 2000-07-27
DE670160T1 (de) 1996-03-14
NZ281228A (en) 1997-06-24
FI963385A (fi) 1996-10-30
PL181714B1 (en) 2001-09-28
NO963588L (no) 1996-10-31
FI963385A0 (fi) 1996-08-30
CA2183952A1 (fr) 1995-09-08
CZ251996A3 (en) 1997-01-15
HUT75677A (en) 1997-05-28
NO315308B1 (no) 2003-08-18
JPH09509669A (ja) 1997-09-30
FI118033B (fi) 2007-06-15
NO963588D0 (no) 1996-08-28
AU681256B2 (en) 1997-08-21

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