CA2166721C - Bicyclic tetrahydro pyrazolopyridines - Google Patents
Bicyclic tetrahydro pyrazolopyridinesInfo
- Publication number
- CA2166721C CA2166721C CA002166721A CA2166721A CA2166721C CA 2166721 C CA2166721 C CA 2166721C CA 002166721 A CA002166721 A CA 002166721A CA 2166721 A CA2166721 A CA 2166721A CA 2166721 C CA2166721 C CA 2166721C
- Authority
- CA
- Canada
- Prior art keywords
- alkyl
- ethyl
- compound
- phenyl
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8829293A | 1993-07-06 | 1993-07-06 | |
US08/088,292 | 1993-07-06 | ||
PCT/IB1994/000156 WO1995001980A1 (en) | 1993-07-06 | 1994-06-16 | Bicyclic tetrahydro pyrazolopyridines |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2166721A1 CA2166721A1 (en) | 1995-01-19 |
CA2166721C true CA2166721C (en) | 1999-07-27 |
Family
ID=22210524
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002166721A Expired - Fee Related CA2166721C (en) | 1993-07-06 | 1994-06-16 | Bicyclic tetrahydro pyrazolopyridines |
Country Status (20)
Country | Link |
---|---|
EP (1) | EP0707585A1 (ru) |
JP (1) | JP2944048B2 (ru) |
KR (1) | KR100228949B1 (ru) |
CN (1) | CN1048015C (ru) |
AU (1) | AU695301B2 (ru) |
BR (1) | BR9406946A (ru) |
CA (1) | CA2166721C (ru) |
CZ (1) | CZ3696A3 (ru) |
EG (1) | EG20513A (ru) |
FI (1) | FI943208A (ru) |
HU (1) | HUT74170A (ru) |
IL (1) | IL110175A (ru) |
MX (1) | MX9405132A (ru) |
NO (1) | NO305029B1 (ru) |
NZ (1) | NZ266525A (ru) |
PL (1) | PL312426A1 (ru) |
RU (1) | RU2131876C1 (ru) |
TW (1) | TW316904B (ru) |
WO (1) | WO1995001980A1 (ru) |
ZA (1) | ZA944844B (ru) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ292991A (en) * | 1994-10-20 | 1999-02-25 | Pfizer | Bicyclic tetrahydropyrazolopyridines that are selective inhibitors of phosphodiesterase (pde) type iv or the production of tnf and pharmaceutical compositions containing them |
CA2223624C (en) * | 1995-06-06 | 2001-02-20 | Pfizer Inc. | Tricyclic 5,6-dihydro-9h-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-.alpha.]pyridines |
AP932A (en) * | 1996-08-26 | 2001-02-02 | Pfizer | Tricyclic 5,6-dihydro-9H-pyrazolo (3,4c)-1,2,4,-triazolo (4,3-a) pyridines. |
TR199900481T2 (xx) * | 1996-09-04 | 1999-06-21 | Pfizer Inc. | �ndazol t�revleri; fosfodiesteraz tip IV inhibit�rleri olarak kullan�mlar�. |
US6858616B2 (en) | 1998-12-23 | 2005-02-22 | Bristol-Myers Squibb Pharma Company | Nitrogen containing heterobicycles as factor Xa inhibitors |
SI1140941T1 (en) | 1998-12-23 | 2005-04-30 | Bristol-Myers Squibb Pharma Company | Nitrogen containing heterobicycles as factor xa inhibitors |
US6326495B2 (en) | 1999-04-30 | 2001-12-04 | Pfizer Inc. | Process for preparing 8-cyclopentyl-6-ethyl-3-[substituted]-5,8-dihydro-4H-1,2,3a,7,8-pentaaza-as-indacenes and intermediates useful therein |
EA006685B1 (ru) | 1999-08-21 | 2006-02-24 | Алтана Фарма Аг | Синергетическая композиция |
TWI243055B (en) * | 2000-04-13 | 2005-11-11 | Nippon Zoki Pharmaceutical Co | Pharmaceutical composition for use in treatment of dermatitis |
AU2001287654B2 (en) * | 2000-08-10 | 2006-12-14 | Pfizer Italia S.R.I. | Bicyclo-pyrazoles active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
US6960595B2 (en) * | 2001-03-23 | 2005-11-01 | Bristol-Myers Squibb Pharma Company | 5-6 to 5-7 Heterobicycles as factor Xa inhibitors |
US6706730B2 (en) | 2001-04-18 | 2004-03-16 | Bristol-Myers Squibb Pharma Company | 1,4,5,6-tetrahydropyrazolo-[3,4-c]-pyridin-7-ones as factor Xa inhibitors |
CA2444571A1 (en) | 2001-04-18 | 2002-10-31 | Bristol-Myers Squibb Company | 1, 4, 5, 6-tetrahydropyrazolo-¬3, 4-c|-pyridin-7-ones as factor xa inhi bitors |
WO2002088122A1 (fr) * | 2001-04-26 | 2002-11-07 | Ajinomoto Co., Inc. | Composes heterocycliques |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
WO2004076450A1 (en) | 2003-02-27 | 2004-09-10 | J. Uriach Y Compañia S.A. | Pyrazolopyridine derivates |
US7135469B2 (en) * | 2003-03-18 | 2006-11-14 | Bristol Myers Squibb, Co. | Linear chain substituted monocyclic and bicyclic derivatives as factor Xa inhibitors |
KR20050115331A (ko) | 2003-04-01 | 2005-12-07 | 어플라이드 리서치 시스템스 에이알에스 홀딩 엔.브이. | 불임증 포스포디에스터라제의 억제제 |
US7145012B2 (en) | 2003-04-23 | 2006-12-05 | Pfizer Inc. | Cannabinoid receptor ligands and uses thereof |
DE102005031580A1 (de) * | 2005-07-06 | 2007-01-11 | Aicuris Gmbh & Co. Kg | Substituierte Sulfolanylpyrazole und ihre Verwendung |
AR065804A1 (es) * | 2007-03-23 | 2009-07-01 | Smithkline Beecham Corp | Compuesto de indol carboxamida, composicion farmaceutica que lo comprende y uso de dicho compuesto para preparar un medicamento |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
US7879802B2 (en) | 2007-06-04 | 2011-02-01 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
US20100120694A1 (en) | 2008-06-04 | 2010-05-13 | Synergy Pharmaceuticals, Inc. | Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders |
EP2321341B1 (en) | 2008-07-16 | 2017-02-22 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
MX357121B (es) | 2011-03-01 | 2018-06-27 | Synergy Pharmaceuticals Inc Star | Proceso de preparacion de agonistas c de guanilato ciclasa. |
CA2902348C (en) | 2013-02-25 | 2021-11-30 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
EP2970384A1 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
BR112015030326A2 (pt) | 2013-06-05 | 2017-08-29 | Synergy Pharmaceuticals Inc | Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos |
WO2015021358A2 (en) | 2013-08-09 | 2015-02-12 | Dominique Charmot | Compounds and methods for inhibiting phosphate transport |
CN110357888A (zh) * | 2018-04-09 | 2019-10-22 | 南京药捷安康生物科技有限公司 | 杂环磷酸二酯酶抑制剂及其用途 |
US20200368223A1 (en) | 2019-05-21 | 2020-11-26 | Ardelyx, Inc. | Methods for inhibiting phosphate transport |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3340269A (en) * | 1964-09-08 | 1967-09-05 | Ciba Geigy Corp | 1-substituted 4-acyl-2, 3-dioxo-piperidine |
US3365459A (en) * | 1964-09-08 | 1968-01-23 | Ciba Geigy Corp | Certain tetrahydro pyrazolo-pyridine and pyrazolo-piperidine derivatives |
FR1463883A (fr) * | 1964-09-08 | 1966-07-22 | Ciba Geigy | Procédé de préparation de triaza-composés bicycliques |
US5356897A (en) * | 1991-09-09 | 1994-10-18 | Fujisawa Pharmaceutical Co., Ltd. | 3-(heteroaryl)-pyrazololi[1,5-a]pyrimidines |
-
1994
- 1994-06-16 RU RU96103653A patent/RU2131876C1/ru active
- 1994-06-16 NZ NZ266525A patent/NZ266525A/en unknown
- 1994-06-16 KR KR1019960700019A patent/KR100228949B1/ko not_active IP Right Cessation
- 1994-06-16 HU HU9503934A patent/HUT74170A/hu unknown
- 1994-06-16 CA CA002166721A patent/CA2166721C/en not_active Expired - Fee Related
- 1994-06-16 BR BR9406946A patent/BR9406946A/pt not_active Application Discontinuation
- 1994-06-16 CN CN94193233A patent/CN1048015C/zh not_active Expired - Fee Related
- 1994-06-16 PL PL94312426A patent/PL312426A1/xx unknown
- 1994-06-16 WO PCT/IB1994/000156 patent/WO1995001980A1/en not_active Application Discontinuation
- 1994-06-16 EP EP94916370A patent/EP0707585A1/en not_active Withdrawn
- 1994-06-16 AU AU68057/94A patent/AU695301B2/en not_active Ceased
- 1994-06-16 CZ CZ9636A patent/CZ3696A3/cs unknown
- 1994-06-16 JP JP7503938A patent/JP2944048B2/ja not_active Expired - Lifetime
- 1994-06-17 TW TW083105518A patent/TW316904B/zh active
- 1994-06-30 IL IL11017594A patent/IL110175A/xx active IP Right Grant
- 1994-07-05 MX MX9405132A patent/MX9405132A/es unknown
- 1994-07-05 FI FI943208A patent/FI943208A/fi unknown
- 1994-07-05 ZA ZA944844A patent/ZA944844B/xx unknown
- 1994-07-05 EG EG40294A patent/EG20513A/xx active
-
1996
- 1996-01-05 NO NO960056A patent/NO305029B1/no unknown
Also Published As
Publication number | Publication date |
---|---|
MX9405132A (es) | 1995-01-31 |
NO305029B1 (no) | 1999-03-22 |
IL110175A (en) | 2000-01-31 |
CN1129940A (zh) | 1996-08-28 |
WO1995001980A1 (en) | 1995-01-19 |
KR960703852A (ko) | 1996-08-31 |
AU695301B2 (en) | 1998-08-13 |
BR9406946A (pt) | 1996-08-06 |
IL110175A0 (en) | 1994-10-07 |
HU9503934D0 (en) | 1996-03-28 |
NO960056D0 (no) | 1996-01-05 |
PL312426A1 (en) | 1996-04-29 |
FI943208A0 (fi) | 1994-07-05 |
EG20513A (en) | 1999-06-30 |
CA2166721A1 (en) | 1995-01-19 |
JP2944048B2 (ja) | 1999-08-30 |
CN1048015C (zh) | 2000-01-05 |
HUT74170A (en) | 1996-11-28 |
CZ3696A3 (en) | 1997-06-11 |
RU2131876C1 (ru) | 1999-06-20 |
ZA944844B (en) | 1996-01-05 |
JPH08507084A (ja) | 1996-07-30 |
NZ266525A (en) | 1997-10-24 |
AU6805794A (en) | 1995-02-06 |
TW316904B (ru) | 1997-10-01 |
FI943208A (fi) | 1995-01-07 |
EP0707585A1 (en) | 1996-04-24 |
NO960056L (no) | 1996-01-05 |
KR100228949B1 (ko) | 1999-11-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |