CA2146548A1 - Heteronaphtoquinones antineoplasiques - Google Patents

Heteronaphtoquinones antineoplasiques

Info

Publication number
CA2146548A1
CA2146548A1 CA002146548A CA2146548A CA2146548A1 CA 2146548 A1 CA2146548 A1 CA 2146548A1 CA 002146548 A CA002146548 A CA 002146548A CA 2146548 A CA2146548 A CA 2146548A CA 2146548 A1 CA2146548 A1 CA 2146548A1
Authority
CA
Canada
Prior art keywords
bch
dioxo
pyran
group
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002146548A
Other languages
English (en)
Inventor
Giorgio Attardo
Tibor Breining
Marc Courchesne
Serge Lamothe
Jean-Francois Lavallee
Dieu Nguyen
Rabindra Rej
Yves St-Denis
Wuyi Wang
Yao-Chang Xu
France Barbeau
Elaine Lebeau
Jean-Louis Kraus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shire Canada Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2146548A1 publication Critical patent/CA2146548A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/76—Benzo[c]pyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/08—Naphthothiopyrans; Hydrogenated naphthothiopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
CA002146548A 1992-11-09 1993-11-05 Heteronaphtoquinones antineoplasiques Abandoned CA2146548A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97323392A 1992-11-09 1992-11-09
US973,233 1992-11-09
PCT/CA1993/000463 WO1994011382A1 (fr) 1992-11-09 1993-11-05 Heteronaphtoquinones antineoplasiques

Publications (1)

Publication Number Publication Date
CA2146548A1 true CA2146548A1 (fr) 1994-05-26

Family

ID=25520651

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002146548A Abandoned CA2146548A1 (fr) 1992-11-09 1993-11-05 Heteronaphtoquinones antineoplasiques

Country Status (6)

Country Link
EP (1) EP0659190A1 (fr)
CN (1) CN1094402A (fr)
AU (1) AU5414094A (fr)
CA (1) CA2146548A1 (fr)
WO (1) WO1994011382A1 (fr)
ZA (1) ZA938350B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6672794A (en) * 1993-11-05 1995-05-23 Biochem Pharma Inc. Antineoplastic heteronaphthoquinones
US5883270A (en) * 1996-02-20 1999-03-16 Wisconsin Alumni Research Foundation 4-substituted-1, 2-naphthoquinones and their use in the inhibition of neoplastic cell growth
US6693099B2 (en) 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
CN102731464B (zh) * 2011-04-12 2014-07-23 沈阳药科大学 一个倍半萜内酯化合物、制备方法及其应用
CN102911177B (zh) * 2012-11-07 2014-07-09 新乡医学院 7-(4-氯苯基)-5,6-二氢-7aH-苯并[h]1,2,4-三氮唑并[3,4-b]喹唑啉-5,6-二酮及其合成方法
CN113278026B (zh) * 2021-05-29 2022-05-13 南京中医药大学 一种具有抗肿瘤活性的苦木素类化合物及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62120379A (ja) * 1985-11-19 1987-06-01 Hoechst Japan Kk フザルビン誘導体およびその製法
AP340A (en) * 1990-06-11 1994-05-13 Iaf Biochem Int Heterocyclic anathracyclinone and anathracycline analogs
NL9001834A (nl) * 1990-08-16 1992-03-16 Pharmachemie Bv Nieuwe antracyclineverbindingen met anti-tumorwerkzaamheid, nieuwe tussenverbindingen voor de bereiding van deze antracyclineverbindingen, alsmede preparaten die de aktieve antracyclineverbindingen bevatten.

Also Published As

Publication number Publication date
WO1994011382A1 (fr) 1994-05-26
ZA938350B (en) 1994-06-21
AU5414094A (en) 1994-06-08
CN1094402A (zh) 1994-11-02
EP0659190A1 (fr) 1995-06-28

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead