EP0659190A1 - Heteronaphtoquinones antineoplasiques - Google Patents

Heteronaphtoquinones antineoplasiques

Info

Publication number
EP0659190A1
EP0659190A1 EP93924460A EP93924460A EP0659190A1 EP 0659190 A1 EP0659190 A1 EP 0659190A1 EP 93924460 A EP93924460 A EP 93924460A EP 93924460 A EP93924460 A EP 93924460A EP 0659190 A1 EP0659190 A1 EP 0659190A1
Authority
EP
European Patent Office
Prior art keywords
dioxo
pyran
lyxohexopyranose
trideoxy
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP93924460A
Other languages
German (de)
English (en)
Inventor
Giorgio Attardo
Tibor Breining
Marc Courchesne
Jean-Louis Kraus
Serge Lamothe
Jean-François LAVALLEE
Elaine Lebeau
Dieu Nguyen
Rabindra Rej
Yves St-Denis
Wuyi Wang
Yao-Chang Xu
France 200 Boulevard Dudomaine Barbeau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shire Canada Inc
Original Assignee
IAF BioChem International Inc
Biochem Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by IAF BioChem International Inc, Biochem Pharma Inc filed Critical IAF BioChem International Inc
Publication of EP0659190A1 publication Critical patent/EP0659190A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/76—Benzo[c]pyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/08—Naphthothiopyrans; Hydrogenated naphthothiopyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Dérivés d'hétéronaphtoquinones tricycliques à activité antinéoplasique, et procédés de synthèse de ces dérivés. Certains de ces composés antinéoplasiques comportent une fraction saccharide. Certains membres de ce groupe structurellement distinct se révèlent actifs contre des cellules cancéreuses résistantes à des médicaments multiples.
EP93924460A 1992-11-09 1993-11-05 Heteronaphtoquinones antineoplasiques Withdrawn EP0659190A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US97323392A 1992-11-09 1992-11-09
US973233 1992-11-09
PCT/CA1993/000463 WO1994011382A1 (fr) 1992-11-09 1993-11-05 Heteronaphtoquinones antineoplasiques

Publications (1)

Publication Number Publication Date
EP0659190A1 true EP0659190A1 (fr) 1995-06-28

Family

ID=25520651

Family Applications (1)

Application Number Title Priority Date Filing Date
EP93924460A Withdrawn EP0659190A1 (fr) 1992-11-09 1993-11-05 Heteronaphtoquinones antineoplasiques

Country Status (6)

Country Link
EP (1) EP0659190A1 (fr)
CN (1) CN1094402A (fr)
AU (1) AU5414094A (fr)
CA (1) CA2146548A1 (fr)
WO (1) WO1994011382A1 (fr)
ZA (1) ZA938350B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995012588A1 (fr) * 1993-11-05 1995-05-11 Biochem Pharma Inc. Heteronaphtoquinones antineoplasiques
US5883270A (en) * 1996-02-20 1999-03-16 Wisconsin Alumni Research Foundation 4-substituted-1, 2-naphthoquinones and their use in the inhibition of neoplastic cell growth
US6693099B2 (en) 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
CN102731464B (zh) * 2011-04-12 2014-07-23 沈阳药科大学 一个倍半萜内酯化合物、制备方法及其应用
CN102911177B (zh) * 2012-11-07 2014-07-09 新乡医学院 7-(4-氯苯基)-5,6-二氢-7aH-苯并[h]1,2,4-三氮唑并[3,4-b]喹唑啉-5,6-二酮及其合成方法
CN113278026B (zh) * 2021-05-29 2022-05-13 南京中医药大学 一种具有抗肿瘤活性的苦木素类化合物及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62120379A (ja) * 1985-11-19 1987-06-01 Hoechst Japan Kk フザルビン誘導体およびその製法
CA2085120A1 (fr) * 1990-06-11 1991-12-12 Biochem Pharma Inc. Analogues heterocycliques d'anthracyclinone et d'anthracycline
NL9001834A (nl) * 1990-08-16 1992-03-16 Pharmachemie Bv Nieuwe antracyclineverbindingen met anti-tumorwerkzaamheid, nieuwe tussenverbindingen voor de bereiding van deze antracyclineverbindingen, alsmede preparaten die de aktieve antracyclineverbindingen bevatten.

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9411382A1 *

Also Published As

Publication number Publication date
WO1994011382A1 (fr) 1994-05-26
ZA938350B (en) 1994-06-21
CA2146548A1 (fr) 1994-05-26
CN1094402A (zh) 1994-11-02
AU5414094A (en) 1994-06-08

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