CA2085120A1 - Analogues heterocycliques d'anthracyclinone et d'anthracycline - Google Patents

Analogues heterocycliques d'anthracyclinone et d'anthracycline

Info

Publication number
CA2085120A1
CA2085120A1 CA002085120A CA2085120A CA2085120A1 CA 2085120 A1 CA2085120 A1 CA 2085120A1 CA 002085120 A CA002085120 A CA 002085120A CA 2085120 A CA2085120 A CA 2085120A CA 2085120 A1 CA2085120 A1 CA 2085120A1
Authority
CA
Canada
Prior art keywords
compound
formula
group
dioxo
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002085120A
Other languages
English (en)
Inventor
Giorgio G. Attardo
Yao Chang Xu
Jean-Francois Lavallee
Rabindra N. Rej
Bernard Belleau (Deceased)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shire Canada Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2085120A1 publication Critical patent/CA2085120A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/76—Benzo[c]pyrans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/06—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/72—Benzo[c]thiophenes; Hydrogenated benzo[c]thiophenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/244—Anthraquinone radicals, e.g. sennosides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
CA002085120A 1990-06-11 1991-06-10 Analogues heterocycliques d'anthracyclinone et d'anthracycline Abandoned CA2085120A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53610790A 1990-06-11 1990-06-11
US536,107 1990-06-11

Publications (1)

Publication Number Publication Date
CA2085120A1 true CA2085120A1 (fr) 1991-12-12

Family

ID=24137175

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002085120A Abandoned CA2085120A1 (fr) 1990-06-11 1991-06-10 Analogues heterocycliques d'anthracyclinone et d'anthracycline

Country Status (18)

Country Link
EP (1) EP0533744A1 (fr)
JP (1) JPH06504034A (fr)
CN (1) CN1058781A (fr)
AP (1) AP340A (fr)
AU (1) AU653348B2 (fr)
CA (1) CA2085120A1 (fr)
CS (1) CS178691A3 (fr)
FI (1) FI925611A0 (fr)
HU (1) HU9203720D0 (fr)
IE (1) IE911965A1 (fr)
IL (1) IL98460A0 (fr)
MA (1) MA22178A1 (fr)
NZ (1) NZ238490A (fr)
PL (1) PL297164A1 (fr)
PT (1) PT97931A (fr)
WO (1) WO1991019725A2 (fr)
YU (1) YU103391A (fr)
ZA (1) ZA914452B (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5736523A (en) * 1992-11-09 1998-04-07 Biochem Pharma Inc. Antineoplastic heteronapthoquinones
CA2146548A1 (fr) * 1992-11-09 1994-05-26 Giorgio Attardo Heteronaphtoquinones antineoplasiques
US5606037A (en) * 1992-11-09 1997-02-25 Biochem Pharma Inc. Processes antineoplastic heteronaphthoquinones
AU6672794A (en) * 1993-11-05 1995-05-23 Biochem Pharma Inc. Antineoplastic heteronaphthoquinones
IT1271689B (it) * 1994-08-04 1997-06-04 Menarini Farma Ind 8-fluoro-antracicline, loro processi di preparazione e composizioni farmaceutiche che le contengono
CA3107596A1 (fr) 2018-08-23 2020-02-27 Seagen Inc. Anticorps anti-tigit
CN111087377B (zh) * 2020-03-19 2020-06-26 广东省微生物研究所（广东省微生物分析检测中心） 苯并异色满醌类化合物及其制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6030315B2 (ja) * 1976-06-01 1985-07-16 三井東圧化学株式会社 ４−ハロゲノメチルイソクマリン誘導体の製造法
JPS52148088A (en) * 1976-06-01 1977-12-08 Richardson Merrell Inc 111aminoalkylmorphansridinee 111ols
GB2067552B (en) * 1980-01-16 1984-02-29 Erba Farmitalia Anthracyline derivatives
JPS60142976A (ja) * 1983-12-28 1985-07-29 Yoshinori Asakawa イソクマリン誘導体
CA1330560C (fr) * 1986-05-21 1994-07-05 Maurits E. A. Vandewalle Derives di- et tetrahydroisoquinoline
JPH01238579A (ja) * 1988-03-18 1989-09-22 Yamanouchi Pharmaceut Co Ltd Ｙ−０５４６０ｍ−ａ物質及びその製造法
JPH08112310A (ja) * 1994-10-18 1996-05-07 New Oji Paper Co Ltd 使いすておむつ

Also Published As

Publication number Publication date
AP340A (en) 1994-05-13
AU653348B2 (en) 1994-09-29
FI925611A (fi) 1992-12-10
JPH06504034A (ja) 1994-05-12
PT97931A (pt) 1992-03-31
MA22178A1 (fr) 1991-12-31
NZ238490A (en) 1994-03-25
PL297164A1 (fr) 1992-10-05
AU8097391A (en) 1992-01-07
EP0533744A1 (fr) 1993-03-31
WO1991019725A3 (fr) 1992-04-30
WO1991019725A2 (fr) 1991-12-26
IE911965A1 (en) 1991-12-18
AP9100278A0 (en) 1991-07-31
CN1058781A (zh) 1992-02-19
ZA914452B (en) 1992-06-24
IL98460A0 (en) 1992-07-15
YU103391A (sh) 1994-04-05
HU9203720D0 (en) 1993-03-29
CS178691A3 (en) 1992-01-15
FI925611A0 (fi) 1992-12-10

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued