CA2145631C - Two-phase matrix for sustained release drug delivery device - Google Patents
Two-phase matrix for sustained release drug delivery device Download PDFInfo
- Publication number
- CA2145631C CA2145631C CA002145631A CA2145631A CA2145631C CA 2145631 C CA2145631 C CA 2145631C CA 002145631 A CA002145631 A CA 002145631A CA 2145631 A CA2145631 A CA 2145631A CA 2145631 C CA2145631 C CA 2145631C
- Authority
- CA
- Canada
- Prior art keywords
- matrix
- drug
- sustained release
- phase
- formulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95663592A | 1992-10-05 | 1992-10-05 | |
| US07/956,635 | 1992-10-05 | ||
| US08/056,076 | 1993-04-30 | ||
| US08/056,076 US5989586A (en) | 1992-10-05 | 1993-04-30 | Two-phase matrix for sustained release drug delivery device |
| PCT/US1993/009510 WO1994007468A1 (en) | 1992-10-05 | 1993-10-05 | Two-phase matrix for sustained release drug delivery device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2145631A1 CA2145631A1 (en) | 1994-04-14 |
| CA2145631C true CA2145631C (en) | 2004-02-10 |
Family
ID=26734946
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002145631A Expired - Lifetime CA2145631C (en) | 1992-10-05 | 1993-10-05 | Two-phase matrix for sustained release drug delivery device |
Country Status (14)
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| US5232702A (en) * | 1991-07-22 | 1993-08-03 | Dow Corning Corporation | Silicone pressure sensitive adhesive compositons for transdermal drug delivery devices and related medical devices |
| US5300299A (en) * | 1991-07-22 | 1994-04-05 | Dow Corning Corporation | Silicone pressure sensitive adhesive containing alkylmethylsiloxane wax and related methods and devices |
| US5989586A (en) * | 1992-10-05 | 1999-11-23 | Cygnus, Inc. | Two-phase matrix for sustained release drug delivery device |
| AU2454495A (en) * | 1994-05-18 | 1995-12-05 | Hisamitsu Pharmaceutical Co., Inc. | Percutaneously administrable preparation for treating urination disorder |
-
1993
- 1993-04-30 US US08/056,076 patent/US5989586A/en not_active Expired - Lifetime
- 1993-10-05 PT PT93923258T patent/PT662822E/pt unknown
- 1993-10-05 CN CN93118244A patent/CN1089469A/zh active Pending
- 1993-10-05 WO PCT/US1993/009510 patent/WO1994007468A1/en active IP Right Grant
- 1993-10-05 DK DK93923258T patent/DK0662822T3/da active
- 1993-10-05 CA CA002145631A patent/CA2145631C/en not_active Expired - Lifetime
- 1993-10-05 AU AU53211/94A patent/AU5321194A/en not_active Abandoned
- 1993-10-05 DE DE69329825T patent/DE69329825T2/de not_active Expired - Lifetime
- 1993-10-05 ES ES93923258T patent/ES2155073T3/es not_active Expired - Lifetime
- 1993-10-05 AT AT93923258T patent/ATE198420T1/de not_active IP Right Cessation
- 1993-10-05 JP JP6509398A patent/JPH08504757A/ja active Pending
- 1993-10-05 EP EP93923258A patent/EP0662822B1/en not_active Expired - Lifetime
- 1993-10-27 TW TW082108949A patent/TW252919B/zh active
-
1995
- 1995-06-07 US US08/474,693 patent/US5840336A/en not_active Expired - Lifetime
-
2001
- 2001-03-23 GR GR20010400471T patent/GR3035626T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US5989586A (en) | 1999-11-23 |
| EP0662822A4 (en) | 1996-08-07 |
| PT662822E (pt) | 2001-04-30 |
| GR3035626T3 (en) | 2001-06-29 |
| DE69329825D1 (de) | 2001-02-08 |
| WO1994007468A1 (en) | 1994-04-14 |
| JPH08504757A (ja) | 1996-05-21 |
| CN1089469A (zh) | 1994-07-20 |
| US5840336A (en) | 1998-11-24 |
| DE69329825T2 (de) | 2001-06-13 |
| CA2145631A1 (en) | 1994-04-14 |
| AU5321194A (en) | 1994-04-26 |
| ES2155073T3 (es) | 2001-05-01 |
| TW252919B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1995-08-01 |
| EP0662822B1 (en) | 2001-01-03 |
| DK0662822T3 (da) | 2001-01-29 |
| EP0662822A1 (en) | 1995-07-19 |
| ATE198420T1 (de) | 2001-01-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKEX | Expiry |
Effective date: 20131007 |