CA2144521A1 - 2-amino-4-phenyl-4-oxo-butyric acid derivatives with kynureninase and/or kynurenine-3-hydroxylase inhibiting activity - Google Patents
2-amino-4-phenyl-4-oxo-butyric acid derivatives with kynureninase and/or kynurenine-3-hydroxylase inhibiting activityInfo
- Publication number
- CA2144521A1 CA2144521A1 CA002144521A CA2144521A CA2144521A1 CA 2144521 A1 CA2144521 A1 CA 2144521A1 CA 002144521 A CA002144521 A CA 002144521A CA 2144521 A CA2144521 A CA 2144521A CA 2144521 A1 CA2144521 A1 CA 2144521A1
- Authority
- CA
- Canada
- Prior art keywords
- formula
- oxo
- amino
- butyric acid
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/20—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI93A001649 | 1993-07-23 | ||
| IT93MI001649A IT1265101B1 (it) | 1993-07-23 | 1993-07-23 | Derivati dell'acido 2-ammino-4-fenil-4-osso butirrico |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2144521A1 true CA2144521A1 (en) | 1995-02-02 |
Family
ID=11366678
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002144521A Abandoned CA2144521A1 (en) | 1993-07-23 | 1994-07-12 | 2-amino-4-phenyl-4-oxo-butyric acid derivatives with kynureninase and/or kynurenine-3-hydroxylase inhibiting activity |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20010008947A1 (enExample) |
| EP (1) | EP0662948B1 (enExample) |
| JP (1) | JPH08501805A (enExample) |
| KR (1) | KR950703517A (enExample) |
| CN (1) | CN1112786A (enExample) |
| AT (1) | ATE171935T1 (enExample) |
| AU (1) | AU678273B2 (enExample) |
| CA (1) | CA2144521A1 (enExample) |
| DE (1) | DE69413789T2 (enExample) |
| DK (1) | DK0662948T3 (enExample) |
| ES (1) | ES2123801T3 (enExample) |
| FI (1) | FI951298L (enExample) |
| HU (1) | HUT70478A (enExample) |
| IL (1) | IL110365A (enExample) |
| IT (1) | IT1265101B1 (enExample) |
| NZ (1) | NZ268896A (enExample) |
| PL (1) | PL179857B1 (enExample) |
| RU (1) | RU2139850C1 (enExample) |
| TW (1) | TW268937B (enExample) |
| WO (1) | WO1995003271A1 (enExample) |
| ZA (1) | ZA945425B (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5519055A (en) * | 1993-08-06 | 1996-05-21 | University Of Maryland At Baltimore | Substituted kynurenines and process for their preparation |
| US5786508A (en) * | 1994-07-15 | 1998-07-28 | Pharmacia & Upjohn S.P.A. | Substituted kynurenines and process for their preparation |
| GB9521486D0 (en) * | 1995-10-20 | 1995-12-20 | Pharmacia Spa | Fluoro-substituted benzoylpropionic acid derivatives |
| GB9615441D0 (en) * | 1996-07-23 | 1996-09-04 | Pharmacia Spa | Benzoylpropionic acid ester derivatives |
| AU3729397A (en) * | 1996-08-16 | 1998-03-06 | Warner-Lambert Company | Butyric acid matrix metalloproteinase inhibitors |
| GB9618349D0 (en) * | 1996-09-03 | 1996-10-16 | Pharmacia Spa | N-substituted 2-amino-4-phenyl-4-oxo-butanoic acid derivatives with kynurenine-3-hydroxylase inhibitory activity |
| GB9716103D0 (en) * | 1997-07-30 | 1997-10-01 | Pharmacia & Upjohn Spa | Condensed heterocyclic compounds |
| GB9725055D0 (en) * | 1997-11-26 | 1998-01-28 | Pharmacia & Upjohn Spa | 1,3,4-thiadiazoles compounds |
| GB9725141D0 (en) * | 1997-11-27 | 1998-01-28 | Pharmacia & Upjohn Spa | Benzenesulfonamide compounds |
| DE69932414T2 (de) * | 1998-02-23 | 2007-02-22 | South Alabama Medical Science Foundation, Mobile | Indol-3-propionsäure, salze und ester davon als arzneimittel # |
| US6783965B1 (en) * | 2000-02-10 | 2004-08-31 | Mountain View Pharmaceuticals, Inc. | Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates |
| WO2000027798A1 (en) * | 1998-11-11 | 2000-05-18 | Novartis Ag | Production of 2-amino-2-[2-(4-c2-20-alkyl-phenyl)ethyl]propane-1,3-diols |
| CN1144779C (zh) * | 1999-03-11 | 2004-04-07 | 杭州中美华东制药有限公司 | 制备2-[2-(4-烷基苯基)-乙基]-2-氨基-丙二醇的方法以及其中制得的中间产物 |
| RU2341513C2 (ru) * | 2001-06-12 | 2008-12-20 | Веллстат Терапьютикс Корпорейшн | Соединения для лечения метаболических заболеваний |
| FR2827045B1 (fr) * | 2001-07-05 | 2007-08-10 | Univ Pasteur | Methodes et compositions pour la selection et le developpement de nouveaux agents pharmacologiques ou de nouveaux medicaments |
| FR2827859B1 (fr) | 2001-07-30 | 2005-09-23 | Lipha | Derives 4-(arylthio) - ou 4-(heteroarylthio) -butyrique dans la preparation de medicaments destines au traitement du diabete |
| CN1330774C (zh) * | 2002-03-01 | 2007-08-08 | 国家人类基因组南方研究中心 | 犬尿氨酸水解酶多态性及其用途 |
| ITMI20041626A1 (it) * | 2004-08-06 | 2004-11-06 | Roberto Pellicciari | Inibitori della chinurenina-ammino-trasferasi |
| CN1309702C (zh) * | 2005-10-28 | 2007-04-11 | 中国科学院上海有机化学研究所 | 犬尿氨酸酶的特异性抑制剂l－邻甲氧基苯甲酰基丙氨酸的合成方法 |
| AU2009226975B2 (en) * | 2008-03-19 | 2012-09-06 | Novartis Ag | Process for the preparation of 2-amino-2- [2- (4-C3-C21-alkyl-phenyl)ethyl] propane-1, 3-diols |
| PT3197466T (pt) * | 2014-09-26 | 2021-05-14 | Univ British Columbia | Combinação de quinurenina e células apresentadoras de antígeno (apc) como agentes terapêuticos e métodos para seu uso na modulação imunológica |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO179912C (no) * | 1990-11-28 | 1997-01-08 | Daiichi Seiyaku Co | Analogifremgangsmåte for fremstilling av et terapeutisk virksomt optisk aktivt pyridobenzoksazinderivat |
| DK0624569T3 (da) * | 1991-02-28 | 1998-10-26 | Merrell Pharma Inc | MMDA-antagonister |
| US5495044A (en) * | 1991-04-18 | 1996-02-27 | University Of Georgia Research Foundation, Inc. | Inhibitors of kynureninase |
| JPH06510023A (ja) * | 1991-04-18 | 1994-11-10 | ユニバーシティ オブ ジョージア リサーチ ファウンデーション，インコーポレイテッド | キヌレニナーゼの阻害剤 |
| GB9325360D0 (en) * | 1993-12-10 | 1994-02-16 | Univ Bristol | Organic compounds |
-
1993
- 1993-07-23 IT IT93MI001649A patent/IT1265101B1/it active IP Right Grant
-
1994
- 1994-07-12 AU AU72285/94A patent/AU678273B2/en not_active Ceased
- 1994-07-12 CN CN94190531A patent/CN1112786A/zh active Pending
- 1994-07-12 CA CA002144521A patent/CA2144521A1/en not_active Abandoned
- 1994-07-12 ES ES94921642T patent/ES2123801T3/es not_active Expired - Lifetime
- 1994-07-12 FI FI951298A patent/FI951298L/fi unknown
- 1994-07-12 JP JP7503289A patent/JPH08501805A/ja active Pending
- 1994-07-12 DK DK94921642T patent/DK0662948T3/da active
- 1994-07-12 KR KR1019950701103A patent/KR950703517A/ko not_active Abandoned
- 1994-07-12 NZ NZ268896A patent/NZ268896A/en unknown
- 1994-07-12 AT AT94921642T patent/ATE171935T1/de not_active IP Right Cessation
- 1994-07-12 WO PCT/EP1994/002280 patent/WO1995003271A1/en not_active Ceased
- 1994-07-12 DE DE69413789T patent/DE69413789T2/de not_active Expired - Fee Related
- 1994-07-12 HU HU9501146A patent/HUT70478A/hu unknown
- 1994-07-12 RU RU95111308A patent/RU2139850C1/ru active
- 1994-07-12 PL PL94308142A patent/PL179857B1/pl unknown
- 1994-07-12 EP EP94921642A patent/EP0662948B1/en not_active Expired - Lifetime
- 1994-07-19 IL IL110365A patent/IL110365A/en not_active IP Right Cessation
- 1994-07-21 TW TW083106674A patent/TW268937B/zh active
- 1994-07-22 ZA ZA945425A patent/ZA945425B/xx unknown
-
1997
- 1997-10-14 US US08/949,392 patent/US20010008947A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ATE171935T1 (de) | 1998-10-15 |
| AU7228594A (en) | 1995-02-20 |
| DK0662948T3 (da) | 1999-06-21 |
| JPH08501805A (ja) | 1996-02-27 |
| EP0662948B1 (en) | 1998-10-07 |
| CN1112786A (zh) | 1995-11-29 |
| NZ268896A (en) | 1997-01-29 |
| HU9501146D0 (en) | 1995-06-28 |
| IL110365A0 (en) | 1994-10-21 |
| DE69413789T2 (de) | 1999-05-06 |
| HUT70478A (en) | 1995-10-30 |
| IL110365A (en) | 1998-06-15 |
| RU2139850C1 (ru) | 1999-10-20 |
| FI951298A7 (fi) | 1995-03-20 |
| PL308142A1 (en) | 1995-07-24 |
| RU95111308A (ru) | 1996-12-27 |
| AU678273B2 (en) | 1997-05-22 |
| FI951298A0 (fi) | 1995-03-20 |
| ES2123801T3 (es) | 1999-01-16 |
| WO1995003271A1 (en) | 1995-02-02 |
| ITMI931649A1 (it) | 1995-01-23 |
| ITMI931649A0 (it) | 1993-07-23 |
| PL179857B1 (pl) | 2000-11-30 |
| DE69413789D1 (de) | 1998-11-12 |
| IT1265101B1 (it) | 1996-10-30 |
| EP0662948A1 (en) | 1995-07-19 |
| ZA945425B (en) | 1995-03-01 |
| US20010008947A1 (en) | 2001-07-19 |
| KR950703517A (ko) | 1995-09-20 |
| TW268937B (enExample) | 1996-01-21 |
| FI951298L (fi) | 1995-03-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |