CA2142721A1 - Condensed indole derivatives as 5ht and 5ht antagonists - Google Patents

Condensed indole derivatives as 5ht and 5ht antagonists

Info

Publication number
CA2142721A1
CA2142721A1 CA002142721A CA2142721A CA2142721A1 CA 2142721 A1 CA2142721 A1 CA 2142721A1 CA 002142721 A CA002142721 A CA 002142721A CA 2142721 A CA2142721 A CA 2142721A CA 2142721 A1 CA2142721 A1 CA 2142721A1
Authority
CA
Canada
Prior art keywords
methyl
indole
dihydropyrrolo
pyridylcarbamoyl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002142721A
Other languages
English (en)
French (fr)
Inventor
Ian T. Forbes
Roger T. Martin
Peter Ham
Thomas P. Blackburn
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929217674A external-priority patent/GB9217674D0/en
Priority claimed from GB939306461A external-priority patent/GB9306461D0/en
Application filed by Individual filed Critical Individual
Publication of CA2142721A1 publication Critical patent/CA2142721A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Heat Sensitive Colour Forming Recording (AREA)
CA002142721A 1992-08-20 1993-07-29 Condensed indole derivatives as 5ht and 5ht antagonists Abandoned CA2142721A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB929217674A GB9217674D0 (en) 1992-08-20 1992-08-20 Novel compounds
GB9217674.2 1993-03-29
GB939306461A GB9306461D0 (en) 1993-03-29 1993-03-29 Novel compounds
GB9306461.6 1993-03-29

Publications (1)

Publication Number Publication Date
CA2142721A1 true CA2142721A1 (en) 1994-03-03

Family

ID=26301461

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002142721A Abandoned CA2142721A1 (en) 1992-08-20 1993-07-29 Condensed indole derivatives as 5ht and 5ht antagonists

Country Status (13)

Country Link
EP (1) EP0656003A1 (ko)
JP (1) JPH08500580A (ko)
CN (1) CN1086819A (ko)
AP (1) AP9300560A0 (ko)
AU (1) AU4704693A (ko)
CA (1) CA2142721A1 (ko)
IL (1) IL106737A0 (ko)
MA (1) MA22955A1 (ko)
MX (1) MX9305037A (ko)
NZ (1) NZ254785A (ko)
SI (1) SI9300438A (ko)
TW (1) TW248557B (ko)
WO (1) WO1994004533A1 (ko)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9306460D0 (en) * 1993-03-29 1993-05-19 Smithkline Beecham Plc Novel compounds
GB9313913D0 (en) * 1993-07-06 1993-08-18 Smithkline Beecham Plc Novel compounds
GB9402542D0 (en) * 1994-02-10 1994-04-06 Smith Kline Beecham Plc Novel compounds
EP0757687A1 (en) * 1994-04-23 1997-02-12 Smithkline Beecham Plc Tricyclic derivatives as 5ht 2c? and 5ht 2b? antagonists
GB9420521D0 (en) * 1994-10-12 1994-11-30 Smithkline Beecham Plc Novel compounds
GB9420999D0 (en) * 1994-10-18 1994-12-07 Smithkline Beecham Plc Novel compounds
JPH10513442A (ja) * 1995-02-02 1998-12-22 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ５−ｈｔレセプターアンタゴニストとしてのインドール誘導体
EP0807104A2 (en) * 1995-02-02 1997-11-19 Smithkline Beecham Plc Heterocyclic compounds possessing 5ht 2c? receptor antagonist activity
GB9517559D0 (en) * 1995-08-26 1995-10-25 Smithkline Beecham Plc Novel compounds
GB9607219D0 (en) * 1996-04-04 1996-06-12 Smithkline Beecham Plc Novel compounds
GB9612883D0 (en) * 1996-06-20 1996-08-21 Smithkline Beecham Plc Novel compounds
GB9612885D0 (en) 1996-06-20 1996-08-21 Smithkline Beecham Plc Novel compounds
WO1998024785A1 (en) * 1996-12-02 1998-06-11 Fujisawa Pharmaceutical Co., Ltd. Indole-urea derivatives with 5-ht antagonist properties
GB9724372D0 (en) * 1997-11-18 1998-01-14 Smithkline Beecham Plc Novel compounds
UA77650C2 (en) 1999-12-06 2007-01-15 Lundbeck & Co As H Use of serotonin reuptake inhibitor in combination with deramcyclane
FR2807754A1 (fr) * 2000-04-13 2001-10-19 Adir Nouveaux derives de cyclobuta-indole carboxamide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2837823B1 (fr) * 2002-03-27 2005-04-08 Servier Lab Nouveaux derives d'indoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2004057338A1 (en) * 2002-12-23 2004-07-08 Bayer Healthcare Ag Diagnostics and therapeutics for diseases assosciated with 5-hydroxytryptamine (serotonin) receptor 2b (5-hteb)
GB0305553D0 (en) * 2003-03-11 2003-04-16 Glaxo Group Ltd Compounds
WO2014049153A1 (en) * 2012-09-28 2014-04-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Antagonists of the 5-ht2b receptor for use in the prevention or treatment of spasticity
US20230312562A1 (en) * 2020-07-02 2023-10-05 Purdue Research Foundation Tetrahydro-3h-pyrazolo quinolone and tetrahydro-3h-pyrrolo[3,2-f]quinoline -containing compounds and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0550507A1 (en) * 1990-09-13 1993-07-14 Beecham Group p.l.c. Indole ureas as 5 ht receptor antagonist

Also Published As

Publication number Publication date
SI9300438A (en) 1994-03-31
IL106737A0 (en) 1994-05-30
MA22955A1 (fr) 1994-04-01
MX9305037A (es) 1994-03-31
AU4704693A (en) 1994-03-15
WO1994004533A1 (en) 1994-03-03
CN1086819A (zh) 1994-05-18
EP0656003A1 (en) 1995-06-07
NZ254785A (en) 1995-09-26
TW248557B (ko) 1995-06-01
JPH08500580A (ja) 1996-01-23
AP9300560A0 (en) 1995-02-19

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Legal Events

Date Code Title Description
FZDE Discontinued