AP9300560A0 - Novel indole and derivatives, processes for their use as medicaments. - Google Patents

Novel indole and derivatives, processes for their use as medicaments.

Info

Publication number
AP9300560A0
AP9300560A0 APAP/P/1993/000560A AP9300560A AP9300560A0 AP 9300560 A0 AP9300560 A0 AP 9300560A0 AP 9300560 A AP9300560 A AP 9300560A AP 9300560 A0 AP9300560 A0 AP 9300560A0
Authority
AP
ARIPO
Prior art keywords
alkyl
hydrogen
medicaments
processes
derivatives
Prior art date
Application number
APAP/P/1993/000560A
Inventor
Ian Thomson Forbes
Roger Thomas Martin
Peter Ham
Thomas Paul Blackburn
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929217674A external-priority patent/GB9217674D0/en
Priority claimed from GB939306461A external-priority patent/GB9306461D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of AP9300560A0 publication Critical patent/AP9300560A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

Compounds of formula (i): wherein: p represents a quinoline or isoquinoline residue, or a 5- or 6-membered aromatic heterocyclic ring containing up to three heteroatoms selected from nitrogen, oxygen or sulphur; r1 is hydrogen or c1-6 alkyl; r2,r3,r10 and r11 are independently hydrogen or c1-6 alkyl, or r10 and r11 together form a bond, or r2 and r10 or r3 and r11 together form a c2-6alkylene chain; r4 hydrogen, c1-6 alkyl, halogen, nr8r9 or12, where r8,r9 and r12 are independently hydrogen or c1-6 alkyl; r5 is hydrogen or c1-6 alkyl; r7 is hydrogen, c1-6 alkyl, or12 or halogen, where r12 is hydrogen or c1-6 alkyl; n is 2 or 3; and the groups r13 and r14 are independently hydrogen or c1-6 alkyl, processes for their preparation and their use as medicaments are disclosed.
APAP/P/1993/000560A 1992-08-20 1993-08-19 Novel indole and derivatives, processes for their use as medicaments. AP9300560A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929217674A GB9217674D0 (en) 1992-08-20 1992-08-20 Novel compounds
GB939306461A GB9306461D0 (en) 1993-03-29 1993-03-29 Novel compounds

Publications (1)

Publication Number Publication Date
AP9300560A0 true AP9300560A0 (en) 1995-02-19

Family

ID=26301461

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1993/000560A AP9300560A0 (en) 1992-08-20 1993-08-19 Novel indole and derivatives, processes for their use as medicaments.

Country Status (13)

Country Link
EP (1) EP0656003A1 (en)
JP (1) JPH08500580A (en)
CN (1) CN1086819A (en)
AP (1) AP9300560A0 (en)
AU (1) AU4704693A (en)
CA (1) CA2142721A1 (en)
IL (1) IL106737A0 (en)
MA (1) MA22955A1 (en)
MX (1) MX9305037A (en)
NZ (1) NZ254785A (en)
SI (1) SI9300438A (en)
TW (1) TW248557B (en)
WO (1) WO1994004533A1 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9306460D0 (en) * 1993-03-29 1993-05-19 Smithkline Beecham Plc Novel compounds
GB9313913D0 (en) * 1993-07-06 1993-08-18 Smithkline Beecham Plc Novel compounds
GB9402542D0 (en) * 1994-02-10 1994-04-06 Smith Kline Beecham Plc Novel compounds
WO1995029177A1 (en) * 1994-04-23 1995-11-02 Smithkline Beecham P.L.C. Tricyclic derivatives as 5ht2c and 5ht2b antagonists
GB9420521D0 (en) * 1994-10-12 1994-11-30 Smithkline Beecham Plc Novel compounds
GB9420999D0 (en) * 1994-10-18 1994-12-07 Smithkline Beecham Plc Novel compounds
EA000304B1 (en) * 1995-02-02 1999-04-29 Смитклайн Бичам Плс Indole derivaties as 5-ht receptor antagonist
WO1996023769A2 (en) * 1995-02-02 1996-08-08 Smithkline Beecham Plc Heterocyclic compounds possessing 5ht2c receptor antagonist activity
GB9517559D0 (en) * 1995-08-26 1995-10-25 Smithkline Beecham Plc Novel compounds
GB9607219D0 (en) * 1996-04-04 1996-06-12 Smithkline Beecham Plc Novel compounds
GB9612883D0 (en) 1996-06-20 1996-08-21 Smithkline Beecham Plc Novel compounds
GB9612885D0 (en) 1996-06-20 1996-08-21 Smithkline Beecham Plc Novel compounds
WO1998024785A1 (en) * 1996-12-02 1998-06-11 Fujisawa Pharmaceutical Co., Ltd. Indole-urea derivatives with 5-ht antagonist properties
GB9724372D0 (en) * 1997-11-18 1998-01-14 Smithkline Beecham Plc Novel compounds
UA77650C2 (en) 1999-12-06 2007-01-15 Lundbeck & Co As H Use of serotonin reuptake inhibitor in combination with deramcyclane
FR2807754A1 (en) * 2000-04-13 2001-10-19 Adir NOVEL CYCLOBUTA-INDOLE CARBOXAMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
FR2837823B1 (en) * 2002-03-27 2005-04-08 Servier Lab NOVEL INDOLIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
AU2003290009A1 (en) * 2002-12-23 2004-07-14 Bayer Healthcare Ag Diagnostics and therapeutics for diseases assosciated with 5-hydroxytryptamine (serotonin) receptor 2b (5-hteb)
GB0305553D0 (en) * 2003-03-11 2003-04-16 Glaxo Group Ltd Compounds
WO2014049153A1 (en) * 2012-09-28 2014-04-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Antagonists of the 5-ht2b receptor for use in the prevention or treatment of spasticity
US20230312562A1 (en) * 2020-07-02 2023-10-05 Purdue Research Foundation Tetrahydro-3h-pyrazolo quinolone and tetrahydro-3h-pyrrolo[3,2-f]quinoline -containing compounds and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT98927A (en) * 1990-09-13 1992-07-31 Beecham Group Plc PROCESS FOR THE PREPARATION OF PYRIDYL-INDOLYL-UREIAS

Also Published As

Publication number Publication date
CA2142721A1 (en) 1994-03-03
EP0656003A1 (en) 1995-06-07
AU4704693A (en) 1994-03-15
IL106737A0 (en) 1994-05-30
TW248557B (en) 1995-06-01
CN1086819A (en) 1994-05-18
WO1994004533A1 (en) 1994-03-03
SI9300438A (en) 1994-03-31
MA22955A1 (en) 1994-04-01
JPH08500580A (en) 1996-01-23
MX9305037A (en) 1994-03-31
NZ254785A (en) 1995-09-26

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