CN1086819A - 有5-羟色胺受体拮抗活性的新化合物 - Google Patents

有5-羟色胺受体拮抗活性的新化合物 Download PDF

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Publication number
CN1086819A
CN1086819A CN93116553A CN93116553A CN1086819A CN 1086819 A CN1086819 A CN 1086819A CN 93116553 A CN93116553 A CN 93116553A CN 93116553 A CN93116553 A CN 93116553A CN 1086819 A CN1086819 A CN 1086819A
Authority
CN
China
Prior art keywords
indoles
methyl
pyrrolin
formyl radical
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN93116553A
Other languages
English (en)
Chinese (zh)
Inventor
I·T·福比斯
R·T·马丁
P·汉姆
T·P·布拉克本恩
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929217674A external-priority patent/GB9217674D0/en
Priority claimed from GB939306461A external-priority patent/GB9306461D0/en
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Publication of CN1086819A publication Critical patent/CN1086819A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Heat Sensitive Colour Forming Recording (AREA)
CN93116553A 1992-08-20 1993-08-19 有5-羟色胺受体拮抗活性的新化合物 Pending CN1086819A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB929217674A GB9217674D0 (en) 1992-08-20 1992-08-20 Novel compounds
GB9217674.2 1993-03-29
GB939306461A GB9306461D0 (en) 1993-03-29 1993-03-29 Novel compounds
GB9306461.6 1993-03-29

Publications (1)

Publication Number Publication Date
CN1086819A true CN1086819A (zh) 1994-05-18

Family

ID=26301461

Family Applications (1)

Application Number Title Priority Date Filing Date
CN93116553A Pending CN1086819A (zh) 1992-08-20 1993-08-19 有5-羟色胺受体拮抗活性的新化合物

Country Status (13)

Country Link
EP (1) EP0656003A1 (ko)
JP (1) JPH08500580A (ko)
CN (1) CN1086819A (ko)
AP (1) AP9300560A0 (ko)
AU (1) AU4704693A (ko)
CA (1) CA2142721A1 (ko)
IL (1) IL106737A0 (ko)
MA (1) MA22955A1 (ko)
MX (1) MX9305037A (ko)
NZ (1) NZ254785A (ko)
SI (1) SI9300438A (ko)
TW (1) TW248557B (ko)
WO (1) WO1994004533A1 (ko)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9306460D0 (en) * 1993-03-29 1993-05-19 Smithkline Beecham Plc Novel compounds
GB9313913D0 (en) * 1993-07-06 1993-08-18 Smithkline Beecham Plc Novel compounds
GB9402542D0 (en) * 1994-02-10 1994-04-06 Smith Kline Beecham Plc Novel compounds
EP0757687A1 (en) * 1994-04-23 1997-02-12 Smithkline Beecham Plc Tricyclic derivatives as 5ht 2c? and 5ht 2b? antagonists
GB9420521D0 (en) * 1994-10-12 1994-11-30 Smithkline Beecham Plc Novel compounds
GB9420999D0 (en) * 1994-10-18 1994-12-07 Smithkline Beecham Plc Novel compounds
JPH10513442A (ja) * 1995-02-02 1998-12-22 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ５−ｈｔレセプターアンタゴニストとしてのインドール誘導体
EP0807104A2 (en) * 1995-02-02 1997-11-19 Smithkline Beecham Plc Heterocyclic compounds possessing 5ht 2c? receptor antagonist activity
GB9517559D0 (en) * 1995-08-26 1995-10-25 Smithkline Beecham Plc Novel compounds
GB9607219D0 (en) * 1996-04-04 1996-06-12 Smithkline Beecham Plc Novel compounds
GB9612883D0 (en) * 1996-06-20 1996-08-21 Smithkline Beecham Plc Novel compounds
GB9612885D0 (en) 1996-06-20 1996-08-21 Smithkline Beecham Plc Novel compounds
WO1998024785A1 (en) * 1996-12-02 1998-06-11 Fujisawa Pharmaceutical Co., Ltd. Indole-urea derivatives with 5-ht antagonist properties
GB9724372D0 (en) * 1997-11-18 1998-01-14 Smithkline Beecham Plc Novel compounds
UA77650C2 (en) 1999-12-06 2007-01-15 Lundbeck & Co As H Use of serotonin reuptake inhibitor in combination with deramcyclane
FR2807754A1 (fr) * 2000-04-13 2001-10-19 Adir Nouveaux derives de cyclobuta-indole carboxamide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2837823B1 (fr) * 2002-03-27 2005-04-08 Servier Lab Nouveaux derives d'indoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
WO2004057338A1 (en) * 2002-12-23 2004-07-08 Bayer Healthcare Ag Diagnostics and therapeutics for diseases assosciated with 5-hydroxytryptamine (serotonin) receptor 2b (5-hteb)
GB0305553D0 (en) * 2003-03-11 2003-04-16 Glaxo Group Ltd Compounds
WO2014049153A1 (en) * 2012-09-28 2014-04-03 INSERM (Institut National de la Santé et de la Recherche Médicale) Antagonists of the 5-ht2b receptor for use in the prevention or treatment of spasticity
US20230312562A1 (en) * 2020-07-02 2023-10-05 Purdue Research Foundation Tetrahydro-3h-pyrazolo quinolone and tetrahydro-3h-pyrrolo[3,2-f]quinoline -containing compounds and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0550507A1 (en) * 1990-09-13 1993-07-14 Beecham Group p.l.c. Indole ureas as 5 ht receptor antagonist

Also Published As

Publication number Publication date
SI9300438A (en) 1994-03-31
IL106737A0 (en) 1994-05-30
MA22955A1 (fr) 1994-04-01
MX9305037A (es) 1994-03-31
AU4704693A (en) 1994-03-15
WO1994004533A1 (en) 1994-03-03
EP0656003A1 (en) 1995-06-07
NZ254785A (en) 1995-09-26
CA2142721A1 (en) 1994-03-03
TW248557B (ko) 1995-06-01
JPH08500580A (ja) 1996-01-23
AP9300560A0 (en) 1995-02-19

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C01 Deemed withdrawal of patent application (patent law 1993)
WD01 Invention patent application deemed withdrawn after publication