CA2138956A1 - 17-alkylketone steroids useful as 5-.alpha.-reductase inhibitors - Google Patents
17-alkylketone steroids useful as 5-.alpha.-reductase inhibitorsInfo
- Publication number
- CA2138956A1 CA2138956A1 CA002138956A CA2138956A CA2138956A1 CA 2138956 A1 CA2138956 A1 CA 2138956A1 CA 002138956 A CA002138956 A CA 002138956A CA 2138956 A CA2138956 A CA 2138956A CA 2138956 A1 CA2138956 A1 CA 2138956A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- formula
- triene
- estra
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
- C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/0065—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified
- C07J7/007—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified not substituted in position 17 alfa
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929213835A GB9213835D0 (en) | 1992-06-30 | 1992-06-30 | Compounds |
| GB9213835.3 | 1992-06-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2138956A1 true CA2138956A1 (en) | 1994-01-06 |
Family
ID=10717920
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002138956A Abandoned CA2138956A1 (en) | 1992-06-30 | 1993-06-30 | 17-alkylketone steroids useful as 5-.alpha.-reductase inhibitors |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP0651643A4 (xx) |
| JP (1) | JPH08500821A (xx) |
| KR (1) | KR950702118A (xx) |
| CN (1) | CN1095382A (xx) |
| AP (1) | AP412A (xx) |
| AU (1) | AU4545993A (xx) |
| BG (1) | BG99313A (xx) |
| BR (1) | BR9306748A (xx) |
| CA (1) | CA2138956A1 (xx) |
| CZ (1) | CZ334694A3 (xx) |
| FI (1) | FI946189A (xx) |
| GB (1) | GB9213835D0 (xx) |
| HU (1) | HUT69409A (xx) |
| IL (1) | IL106158A0 (xx) |
| MA (1) | MA22927A1 (xx) |
| MX (1) | MX9303970A (xx) |
| NO (1) | NO945074L (xx) |
| OA (1) | OA10122A (xx) |
| RU (1) | RU94046378A (xx) |
| SI (1) | SI9300350A (xx) |
| SK (1) | SK159994A3 (xx) |
| WO (1) | WO1994000125A1 (xx) |
| ZA (1) | ZA934645B (xx) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5925774A (en) | 1991-01-07 | 1999-07-20 | Pherin Corporation | Estrenes for inducing hypothalamic effects |
| CA2135056A1 (en) * | 1992-05-20 | 1993-11-25 | Donald W. Graham | New delta-17 and delta-20 olefinic and saturated 17b-substituted-4-aza-5a-andros-tan-3-ones as 5a-reductase inhibitors |
| US5543417A (en) * | 1994-10-21 | 1996-08-06 | Merck & Co., Inc. | Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents |
| GB201102913D0 (en) | 2011-02-18 | 2011-04-06 | Univ Birmingham | Novel therapeutic |
| JP2015129095A (ja) | 2013-12-19 | 2015-07-16 | ロレアル | 組成物 |
| CA3090724A1 (en) * | 2018-02-11 | 2019-08-15 | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. | Steroid derivative regulators, method for preparing the same, and uses thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4954446A (en) * | 1988-05-25 | 1990-09-04 | Smithkline Beecham Corporation | Aromatic steroid 5-α-reductase inhibitors |
-
1992
- 1992-06-30 GB GB929213835A patent/GB9213835D0/en active Pending
-
1993
- 1993-06-26 ZA ZA934645A patent/ZA934645B/xx unknown
- 1993-06-28 MA MA23217A patent/MA22927A1/fr unknown
- 1993-06-28 IL IL106158A patent/IL106158A0/xx unknown
- 1993-06-30 CA CA002138956A patent/CA2138956A1/en not_active Abandoned
- 1993-06-30 CN CN93109540A patent/CN1095382A/zh active Pending
- 1993-06-30 BR BR9306748A patent/BR9306748A/pt not_active Application Discontinuation
- 1993-06-30 JP JP6502660A patent/JPH08500821A/ja active Pending
- 1993-06-30 WO PCT/US1993/006238 patent/WO1994000125A1/en not_active Application Discontinuation
- 1993-06-30 RU RU94046378/04A patent/RU94046378A/ru unknown
- 1993-06-30 SI SI9300350A patent/SI9300350A/sl unknown
- 1993-06-30 AP APAP/P/1993/000542A patent/AP412A/en active
- 1993-06-30 CZ CZ943346A patent/CZ334694A3/cs unknown
- 1993-06-30 EP EP93915499A patent/EP0651643A4/en not_active Withdrawn
- 1993-06-30 HU HU9403833A patent/HUT69409A/hu unknown
- 1993-06-30 SK SK1599-94A patent/SK159994A3/sk unknown
- 1993-06-30 MX MX9303970A patent/MX9303970A/es unknown
- 1993-06-30 AU AU45459/93A patent/AU4545993A/en not_active Abandoned
-
1994
- 1994-12-29 OA OA60599A patent/OA10122A/en unknown
- 1994-12-29 KR KR1019940704802A patent/KR950702118A/ko not_active Application Discontinuation
- 1994-12-29 NO NO945074A patent/NO945074L/no unknown
- 1994-12-29 BG BG99313A patent/BG99313A/xx unknown
- 1994-12-30 FI FI946189A patent/FI946189A/fi not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| GB9213835D0 (en) | 1992-08-12 |
| EP0651643A4 (en) | 1995-10-04 |
| CN1095382A (zh) | 1994-11-23 |
| AU4545993A (en) | 1994-01-24 |
| ZA934645B (en) | 1994-01-25 |
| MX9303970A (es) | 1994-04-29 |
| FI946189A0 (fi) | 1994-12-30 |
| IL106158A0 (en) | 1993-10-20 |
| RU94046378A (ru) | 1996-10-10 |
| KR950702118A (ko) | 1995-06-19 |
| FI946189A (fi) | 1994-12-30 |
| OA10122A (en) | 1996-12-18 |
| SK159994A3 (en) | 1996-01-10 |
| NO945074D0 (no) | 1994-12-29 |
| CZ334694A3 (en) | 1995-10-18 |
| NO945074L (no) | 1995-02-16 |
| EP0651643A1 (en) | 1995-05-10 |
| AP9300542A0 (en) | 1993-07-31 |
| JPH08500821A (ja) | 1996-01-30 |
| AP412A (en) | 1995-09-29 |
| WO1994000125A1 (en) | 1994-01-06 |
| HUT69409A (en) | 1995-09-28 |
| BR9306748A (pt) | 1998-12-08 |
| SI9300350A (sl) | 1993-12-31 |
| MA22927A1 (fr) | 1994-04-01 |
| BG99313A (en) | 1995-09-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |