AP412A - 17a and 17B-Alkylketone-3-carboxyaromatic a ring steroidal compounds and pharmaceutical compositions containing these compounds. - Google Patents

17a and 17B-Alkylketone-3-carboxyaromatic a ring steroidal compounds and pharmaceutical compositions containing these compounds. Download PDF

Info

Publication number
AP412A
AP412A APAP/P/1993/000542A AP9300542A AP412A AP 412 A AP412 A AP 412A AP 9300542 A AP9300542 A AP 9300542A AP 412 A AP412 A AP 412A
Authority
AP
ARIPO
Prior art keywords
compound
triene
estra
formula
carboxylic acid
Prior art date
Application number
APAP/P/1993/000542A
Other languages
English (en)
Other versions
AP9300542A0 (en
Inventor
Dennis Alan Holt
Mark Alan Levy
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of AP9300542A0 publication Critical patent/AP9300542A0/xx
Application granted granted Critical
Publication of AP412A publication Critical patent/AP412A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/0065—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified
    • C07J7/007—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified not substituted in position 17 alfa
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
APAP/P/1993/000542A 1992-06-30 1993-06-30 17a and 17B-Alkylketone-3-carboxyaromatic a ring steroidal compounds and pharmaceutical compositions containing these compounds. AP412A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929213835A GB9213835D0 (en) 1992-06-30 1992-06-30 Compounds

Publications (2)

Publication Number Publication Date
AP9300542A0 AP9300542A0 (en) 1993-07-31
AP412A true AP412A (en) 1995-09-29

Family

ID=10717920

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1993/000542A AP412A (en) 1992-06-30 1993-06-30 17a and 17B-Alkylketone-3-carboxyaromatic a ring steroidal compounds and pharmaceutical compositions containing these compounds.

Country Status (23)

Country Link
EP (1) EP0651643A4 (xx)
JP (1) JPH08500821A (xx)
KR (1) KR950702118A (xx)
CN (1) CN1095382A (xx)
AP (1) AP412A (xx)
AU (1) AU4545993A (xx)
BG (1) BG99313A (xx)
BR (1) BR9306748A (xx)
CA (1) CA2138956A1 (xx)
CZ (1) CZ334694A3 (xx)
FI (1) FI946189A0 (xx)
GB (1) GB9213835D0 (xx)
HU (1) HUT69409A (xx)
IL (1) IL106158A0 (xx)
MA (1) MA22927A1 (xx)
MX (1) MX9303970A (xx)
NO (1) NO945074L (xx)
OA (1) OA10122A (xx)
RU (1) RU94046378A (xx)
SI (1) SI9300350A (xx)
SK (1) SK159994A3 (xx)
WO (1) WO1994000125A1 (xx)
ZA (1) ZA934645B (xx)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5925774A (en) * 1991-01-07 1999-07-20 Pherin Corporation Estrenes for inducing hypothalamic effects
CA2135056A1 (en) * 1992-05-20 1993-11-25 Donald W. Graham New delta-17 and delta-20 olefinic and saturated 17b-substituted-4-aza-5a-andros-tan-3-ones as 5a-reductase inhibitors
US5543417A (en) * 1994-10-21 1996-08-06 Merck & Co., Inc. Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents
GB201102913D0 (en) 2011-02-18 2011-04-06 Univ Birmingham Novel therapeutic
JP2015129095A (ja) 2013-12-19 2015-07-16 ロレアル 組成物
JP7438956B2 (ja) * 2018-02-11 2024-02-27 江▲蘇▼豪森▲薬▼▲業▼集▲団▼有限公司 ステロイド系誘導体モジュレーター、その製造方法及び応用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4954446A (en) * 1988-05-25 1990-09-04 Smithkline Beecham Corporation Aromatic steroid 5-α-reductase inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4954446A (en) * 1988-05-25 1990-09-04 Smithkline Beecham Corporation Aromatic steroid 5-α-reductase inhibitors

Also Published As

Publication number Publication date
AP9300542A0 (en) 1993-07-31
NO945074L (no) 1995-02-16
EP0651643A1 (en) 1995-05-10
CA2138956A1 (en) 1994-01-06
FI946189A (fi) 1994-12-30
MX9303970A (es) 1994-04-29
SI9300350A (sl) 1993-12-31
OA10122A (en) 1996-12-18
EP0651643A4 (en) 1995-10-04
NO945074D0 (no) 1994-12-29
IL106158A0 (en) 1993-10-20
RU94046378A (ru) 1996-10-10
CN1095382A (zh) 1994-11-23
BG99313A (en) 1995-09-29
HUT69409A (en) 1995-09-28
GB9213835D0 (en) 1992-08-12
WO1994000125A1 (en) 1994-01-06
BR9306748A (pt) 1998-12-08
AU4545993A (en) 1994-01-24
CZ334694A3 (en) 1995-10-18
FI946189A0 (fi) 1994-12-30
MA22927A1 (fr) 1994-04-01
JPH08500821A (ja) 1996-01-30
SK159994A3 (en) 1996-01-10
ZA934645B (en) 1994-01-25
KR950702118A (ko) 1995-06-19

Similar Documents

Publication Publication Date Title
DK175522B1 (da) Steroid 5-alfa-reduktase inhibitorer
CA1319362C (en) 4-substituted androstendione derivatives and process for their preparation
JP2675418B2 (ja) 芳香族ステロイド５‐α‐レダクターゼ抑制剤
US5032586A (en) 7-keto or hydroxy 3,5-diene steroids as inhibitors of steroid 5-alpha reductase
US5527806A (en) 17α and 17β substituted acyl 4 aza steroids
AP412A (en) 17a and 17B-Alkylketone-3-carboxyaromatic a ring steroidal compounds and pharmaceutical compositions containing these compounds.
US5137882A (en) Steroidal 3-acetic acid derivatives as 5-alpha-reductase inhibitors
WO1994011004A1 (en) 17 substituted acyl-3-carboxy 3,5-diene steroidals as 5-alpha-reductase inhibitors
US5618806A (en) 17α and 17β-substituted estra-1,3,5(10)-triene-3-carbboxlic acid
US5641877A (en) 17-α and 17-β substituted acyl-3-carboxy-3, 5-dienes and use in inhibiting 5-α-reductase
US5683995A (en) 17 substituted acyl-3-carboxy 3,5-diene steroidals as α-reductase inhibitors
WO1995021185A1 (en) Acyl 3-carboxy aromatic a ring steroid as 5-alpha reductase inhibitors
WO1994000121A1 (en) 17-acyl-4-aza-steroid-3-one as 5-alpha-reductase inhibitors
JPH08503474A (ja) １７‐アルファおよび１７‐ベータ置換アシル−３−カルボキシ−３，５−ジエンおよび５−アルファ−リダクターゼの阻害における使用