SK159994A3 - 17-alkylketone steroids useful as 5-alpha-reductase inhibitors - Google Patents

17-alkylketone steroids useful as 5-alpha-reductase inhibitors Download PDF

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Publication number
SK159994A3
SK159994A3 SK1599-94A SK159994A SK159994A3 SK 159994 A3 SK159994 A3 SK 159994A3 SK 159994 A SK159994 A SK 159994A SK 159994 A3 SK159994 A3 SK 159994A3
Authority
SK
Slovakia
Prior art keywords
compound
formula
compound according
estra
triene
Prior art date
Application number
SK1599-94A
Other languages
English (en)
Slovak (sk)
Inventor
Dennis Alan Holt
Mark A Levy
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of SK159994A3 publication Critical patent/SK159994A3/sk

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/0015—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa
    • C07J7/002—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group not substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/0065—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified
    • C07J7/007—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by an OH group free esterified or etherified not substituted in position 17 alfa
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SK1599-94A 1992-06-30 1993-06-30 17-alkylketone steroids useful as 5-alpha-reductase inhibitors SK159994A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929213835A GB9213835D0 (en) 1992-06-30 1992-06-30 Compounds
PCT/US1993/006238 WO1994000125A1 (en) 1992-06-30 1993-06-30 17-ALKYLKETONE STEROIDS USEFUL AS 5-α-REDUCTASE INHIBITORS

Publications (1)

Publication Number Publication Date
SK159994A3 true SK159994A3 (en) 1996-01-10

Family

ID=10717920

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1599-94A SK159994A3 (en) 1992-06-30 1993-06-30 17-alkylketone steroids useful as 5-alpha-reductase inhibitors

Country Status (23)

Country Link
EP (1) EP0651643A4 (xx)
JP (1) JPH08500821A (xx)
KR (1) KR950702118A (xx)
CN (1) CN1095382A (xx)
AP (1) AP412A (xx)
AU (1) AU4545993A (xx)
BG (1) BG99313A (xx)
BR (1) BR9306748A (xx)
CA (1) CA2138956A1 (xx)
CZ (1) CZ334694A3 (xx)
FI (1) FI946189A (xx)
GB (1) GB9213835D0 (xx)
HU (1) HUT69409A (xx)
IL (1) IL106158A0 (xx)
MA (1) MA22927A1 (xx)
MX (1) MX9303970A (xx)
NO (1) NO945074L (xx)
OA (1) OA10122A (xx)
RU (1) RU94046378A (xx)
SI (1) SI9300350A (xx)
SK (1) SK159994A3 (xx)
WO (1) WO1994000125A1 (xx)
ZA (1) ZA934645B (xx)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5925774A (en) 1991-01-07 1999-07-20 Pherin Corporation Estrenes for inducing hypothalamic effects
CA2135056A1 (en) * 1992-05-20 1993-11-25 Donald W. Graham New delta-17 and delta-20 olefinic and saturated 17b-substituted-4-aza-5a-andros-tan-3-ones as 5a-reductase inhibitors
US5543417A (en) * 1994-10-21 1996-08-06 Merck & Co., Inc. Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents
GB201102913D0 (en) 2011-02-18 2011-04-06 Univ Birmingham Novel therapeutic
JP2015129095A (ja) 2013-12-19 2015-07-16 ロレアル 組成物
CA3090724A1 (en) * 2018-02-11 2019-08-15 Jiangsu Hansoh Pharmaceutical Group Co., Ltd. Steroid derivative regulators, method for preparing the same, and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4954446A (en) * 1988-05-25 1990-09-04 Smithkline Beecham Corporation Aromatic steroid 5-α-reductase inhibitors

Also Published As

Publication number Publication date
CA2138956A1 (en) 1994-01-06
GB9213835D0 (en) 1992-08-12
EP0651643A4 (en) 1995-10-04
CN1095382A (zh) 1994-11-23
AU4545993A (en) 1994-01-24
ZA934645B (en) 1994-01-25
MX9303970A (es) 1994-04-29
FI946189A0 (fi) 1994-12-30
IL106158A0 (en) 1993-10-20
RU94046378A (ru) 1996-10-10
KR950702118A (ko) 1995-06-19
FI946189A (fi) 1994-12-30
OA10122A (en) 1996-12-18
NO945074D0 (no) 1994-12-29
CZ334694A3 (en) 1995-10-18
NO945074L (no) 1995-02-16
EP0651643A1 (en) 1995-05-10
AP9300542A0 (en) 1993-07-31
JPH08500821A (ja) 1996-01-30
AP412A (en) 1995-09-29
WO1994000125A1 (en) 1994-01-06
HUT69409A (en) 1995-09-28
BR9306748A (pt) 1998-12-08
SI9300350A (sl) 1993-12-31
MA22927A1 (fr) 1994-04-01
BG99313A (en) 1995-09-29

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