CA2137793C - Crystallization of m-csf - Google Patents
Crystallization of m-csf Download PDFInfo
- Publication number
- CA2137793C CA2137793C CA002137793A CA2137793A CA2137793C CA 2137793 C CA2137793 C CA 2137793C CA 002137793 A CA002137793 A CA 002137793A CA 2137793 A CA2137793 A CA 2137793A CA 2137793 C CA2137793 C CA 2137793C
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- Prior art keywords
- csf
- alpha
- monomers
- gln
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7153—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for colony-stimulating factors [CSF]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US89651292A | 1992-06-09 | 1992-06-09 | |
| US07/896,512 | 1992-06-09 | ||
| PCT/US1993/005548 WO1993025687A1 (en) | 1992-06-09 | 1993-06-09 | Crystallization of m-csf |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2137793A1 CA2137793A1 (en) | 1993-12-23 |
| CA2137793C true CA2137793C (en) | 2003-04-22 |
Family
ID=25406334
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002137793A Expired - Lifetime CA2137793C (en) | 1992-06-09 | 1993-06-09 | Crystallization of m-csf |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US5866114A (enExample) |
| EP (2) | EP0955365A3 (enExample) |
| JP (2) | JPH08507916A (enExample) |
| AT (1) | ATE195553T1 (enExample) |
| CA (1) | CA2137793C (enExample) |
| DE (1) | DE69329247T2 (enExample) |
| WO (1) | WO1993025687A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US5581476A (en) * | 1993-01-28 | 1996-12-03 | Amgen Inc. | Computer-based methods and articles of manufacture for preparing G-CSF analogs |
| CA2249007A1 (en) * | 1996-03-14 | 1997-09-18 | Takeshi Shibuya | Parasite-derived anti-inflammatory immunomodulatory protein |
| AU1759501A (en) * | 1999-11-08 | 2001-06-06 | Government of The United States of America, as represented by The Secretary Department of Health & Human Services, The National Institutes of Health, The | Method of treating a viral infection using antagonists of macrophage colony stimulating factor |
| PL374181A1 (en) | 2001-02-09 | 2005-10-03 | Genentech, Inc. | Crystallization of igf-1 |
| US7247618B2 (en) * | 2001-04-30 | 2007-07-24 | Tripathi Rajavashisth | Methods for inhibiting macrophage colony stimulating factor and c-FMS-dependent cell signaling |
| EP1425304B9 (en) | 2001-07-11 | 2010-09-08 | Maxygen, Inc. | G-csf conjugates |
| US7563595B2 (en) * | 2002-11-08 | 2009-07-21 | University Of South Florida | Nucleic acids encoding functional splice variants of the α7 nicotinic acetylcholine receptor subunit and methods for producing the encoded proteins |
| AR045563A1 (es) | 2003-09-10 | 2005-11-02 | Warner Lambert Co | Anticuerpos dirigidos a m-csf |
| WO2005057169A2 (en) * | 2003-12-05 | 2005-06-23 | Trellis Bioscience, Inc. | Homogeneous competition assays |
| WO2005070447A2 (en) * | 2004-01-21 | 2005-08-04 | Chiron Corporation | M-csf muteins and uses thereof |
| WO2006047505A2 (en) * | 2004-10-22 | 2006-05-04 | Janssen Pharmaceutica, N.V. | Crystal structure of the c-fms kinase domain |
| EP1888119B1 (en) | 2005-06-01 | 2011-03-09 | Maxygen, Inc. | Pegylated g-csf polypeptides and methods of producing same |
| KR100970770B1 (ko) | 2008-02-12 | 2010-07-16 | 한국기초과학지원연구원 | 결정성 재조합 단백질 휴먼 에스피오티 및 이의 결정화방법 |
| WO2010062399A2 (en) * | 2008-11-26 | 2010-06-03 | Five Prime Therapeutics, Inc. | Csf1r extracellular domain fusion molecules and treatments using same |
| WO2010062401A2 (en) * | 2008-11-26 | 2010-06-03 | Five Prime Therapeutics, Inc. | Treatment of osteolytic disorders and cancer using csf1r extracellular domain fusion molecules |
| AR075899A1 (es) * | 2009-03-20 | 2011-05-04 | Onyx Therapeutics Inc | Tripeptidos epoxicetonas cristalinos inhibidores de proteasa |
| RU2565541C2 (ru) | 2009-12-10 | 2015-10-20 | Ф.Хоффманн-Ля Рош Аг | Антитела, связывающиеся преимущественно с внеклеточным доменом 4 человеческого csf-1r, и их применение |
| CA2789076C (en) | 2010-03-05 | 2017-11-21 | F. Hoffmann-La Roche Ag | Antibodies against human colony stimulating factor-1 receptor and uses thereof |
| US9221910B2 (en) | 2010-03-05 | 2015-12-29 | Hoffmann-La Roche Inc. | Antibodies against human CSF-1R |
| CN107011438B (zh) | 2010-05-04 | 2020-11-20 | 戊瑞治疗有限公司 | 结合csf1r的抗体 |
| WO2013036829A1 (en) | 2011-09-09 | 2013-03-14 | Genentech, Inc | Treatment of th17 mediated inflammatory diseases |
| CN104159921B (zh) | 2011-12-15 | 2018-05-04 | 霍夫曼-拉罗奇有限公司 | 针对人csf-1r的抗体及其用途 |
| US20130302322A1 (en) | 2012-05-11 | 2013-11-14 | Five Prime Therapeutics, Inc. | Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r) |
| TWI713436B (zh) | 2012-08-31 | 2020-12-21 | 美商戊瑞治療有限公司 | 用結合群落刺激因子１受體（ｃｓｆ１ｒ）之抗體治療病狀之方法 |
| AR095882A1 (es) | 2013-04-22 | 2015-11-18 | Hoffmann La Roche | Terapia de combinación de anticuerpos contra csf-1r humano con un agonista de tlr9 |
| AR097584A1 (es) | 2013-09-12 | 2016-03-23 | Hoffmann La Roche | Terapia de combinación de anticuerpos contra el csf-1r humano y anticuerpos contra el pd-l1 humano |
| WO2015200089A1 (en) | 2014-06-23 | 2015-12-30 | Five Prime Therapeutics, Inc. | Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r) |
| HRP20210440T1 (hr) | 2014-10-29 | 2021-04-30 | Five Prime Therapeutics, Inc. | Kombinirana terapija za rak |
| SG11201704792UA (en) | 2014-12-22 | 2017-07-28 | Five Prime Therapeutics Inc | Anti-csf1r antibodies for treating pvns |
| HUE053903T2 (hu) | 2015-04-13 | 2021-07-28 | Five Prime Therapeutics Inc | Kombinációs terápia rák ellen |
| JP7138094B2 (ja) | 2016-08-25 | 2022-09-15 | エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト | マクロファージ活性化剤と組み合わせた抗ｃｓｆ－１ｒ抗体の間欠投与 |
| EP3558360A1 (en) | 2016-12-22 | 2019-10-30 | F. Hoffmann-La Roche AG | Treatment of tumors with an anti-csf-1r antibody in combination with an anti-pd-l1 antibody after failure of anti-pd-l1/pd1 treatment |
| CN106843149A (zh) * | 2017-03-28 | 2017-06-13 | 吴小江 | 一种机械零固件产品加工系统 |
| SG11202001606XA (en) | 2017-09-13 | 2020-03-30 | Five Prime Therapeutics Inc | Combination anti-csf1r and anti-pd-1 antibody combination therapy for pancreatic cancer |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4672108A (en) * | 1981-12-07 | 1987-06-09 | Hoffmann-La Roche Inc. | Crystalline human leukocyte interferon |
| US4582788A (en) | 1982-01-22 | 1986-04-15 | Cetus Corporation | HLA typing method and cDNA probes used therein |
| US4966911A (en) * | 1984-11-20 | 1990-10-30 | Washington Research Foundation | Immunoregulatory agents |
| US4847201A (en) * | 1985-02-05 | 1989-07-11 | Cetus Corporation | DNA encoding for CSF-1 and accompanying recombinant systems |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| JPS62106000A (ja) * | 1985-10-30 | 1987-05-16 | Fujitsu Ltd | 生体高分子結晶自動作製装置 |
| US4908773A (en) * | 1987-04-06 | 1990-03-13 | Genex Corporation | Computer designed stabilized proteins and method for producing same |
| US4946778A (en) * | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US4881175A (en) * | 1986-09-02 | 1989-11-14 | Genex Corporation | Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides |
| US5032676A (en) | 1986-10-14 | 1991-07-16 | Immunex Corporation | Nonglycosylated analogs of human colony stimulating factors |
| WO1988003173A2 (en) * | 1986-10-24 | 1988-05-05 | Cetus Corporation | New forms of colony stimulating factor-1 |
| IL86090A (en) * | 1987-04-16 | 1993-03-15 | Cetus Oncology Corp | Production of purified, biologically active, bacterially produced recombinant human csf-1 |
| US4929700A (en) * | 1987-04-16 | 1990-05-29 | Cetus Corporation | Production of purified, biologically active, bacterially produced recombinant human CSF-1 |
| US4833233A (en) * | 1987-08-20 | 1989-05-23 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Human serum albumin crystals and method of preparation |
| ES2063783T3 (es) * | 1988-06-03 | 1995-01-16 | Chugai Pharmaceutical Co Ltd | Factor de cristalino humano de estimulacion de colonias de granulocitos y procedimiento para su preparacion. |
| US5109119A (en) * | 1989-06-06 | 1992-04-28 | Schering Corporation | Crystalline r-h-gm-csf and method |
| IE66494B1 (en) * | 1989-09-26 | 1996-01-10 | Immunex Corp | Granulocyte-colony stimulating factor receptors |
| WO1991009943A1 (en) * | 1989-12-21 | 1991-07-11 | Novo Nordisk A/S | Method for crystallization of enzymes |
| ATE196548T1 (de) * | 1991-05-10 | 2000-10-15 | Genentech Inc | Auswählen von agonisten und antagonisten von liganden |
-
1993
- 1993-06-09 EP EP99108304A patent/EP0955365A3/en not_active Withdrawn
- 1993-06-09 AT AT93915279T patent/ATE195553T1/de not_active IP Right Cessation
- 1993-06-09 US US08/351,292 patent/US5866114A/en not_active Expired - Lifetime
- 1993-06-09 EP EP93915279A patent/EP0668914B1/en not_active Expired - Lifetime
- 1993-06-09 CA CA002137793A patent/CA2137793C/en not_active Expired - Lifetime
- 1993-06-09 DE DE69329247T patent/DE69329247T2/de not_active Expired - Lifetime
- 1993-06-09 JP JP6501713A patent/JPH08507916A/ja not_active Withdrawn
- 1993-06-09 WO PCT/US1993/005548 patent/WO1993025687A1/en not_active Ceased
-
1995
- 1995-06-05 US US08/462,794 patent/US6184354B1/en not_active Expired - Lifetime
-
2004
- 2004-05-25 JP JP2004155357A patent/JP2004285076A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP0668914B1 (en) | 2000-08-16 |
| EP0955365A2 (en) | 1999-11-10 |
| DE69329247T2 (de) | 2001-05-31 |
| WO1993025687A1 (en) | 1993-12-23 |
| US6184354B1 (en) | 2001-02-06 |
| ATE195553T1 (de) | 2000-09-15 |
| EP0955365A3 (en) | 2000-12-20 |
| CA2137793A1 (en) | 1993-12-23 |
| US5866114A (en) | 1999-02-02 |
| JP2004285076A (ja) | 2004-10-14 |
| DE69329247D1 (de) | 2000-09-21 |
| JPH08507916A (ja) | 1996-08-27 |
| EP0668914A1 (en) | 1995-08-30 |
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| EEER | Examination request |