CA2109820A1 - Repliement et purification du facteur de croissance apparente a l'insuline i - Google Patents
Repliement et purification du facteur de croissance apparente a l'insuline iInfo
- Publication number
- CA2109820A1 CA2109820A1 CA002109820A CA2109820A CA2109820A1 CA 2109820 A1 CA2109820 A1 CA 2109820A1 CA 002109820 A CA002109820 A CA 002109820A CA 2109820 A CA2109820 A CA 2109820A CA 2109820 A1 CA2109820 A1 CA 2109820A1
- Authority
- CA
- Canada
- Prior art keywords
- igf
- solution
- met
- biologically active
- reducing agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US85816692A | 1992-03-24 | 1992-03-24 | |
| US07/858,161 | 1992-03-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2109820A1 true CA2109820A1 (fr) | 1993-09-30 |
Family
ID=25327654
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002109820A Abandoned CA2109820A1 (fr) | 1992-03-24 | 1993-03-19 | Repliement et purification du facteur de croissance apparente a l'insuline i |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP0586667A1 (fr) |
| AU (1) | AU3812993A (fr) |
| CA (1) | CA2109820A1 (fr) |
| WO (1) | WO1993019084A1 (fr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5663304A (en) * | 1993-08-20 | 1997-09-02 | Genentech, Inc. | Refolding of misfolded insulin-like growth factor-I |
| SE9303784D0 (sv) * | 1993-11-16 | 1993-11-16 | Kabi Pharmacia Ab | Igf |
| US6756484B1 (en) | 1995-04-14 | 2004-06-29 | Cephalon, Inc. | IGF-I purification process |
| US5650496A (en) * | 1995-04-14 | 1997-07-22 | Cephalon, Inc. | IGF-I purification process |
| ATE253079T1 (de) * | 1995-06-07 | 2003-11-15 | Chiron Corp | Methoden zur aufreinigung von authentischem igf aus hefewirtszellen |
| US7071313B1 (en) | 1995-06-07 | 2006-07-04 | Cephalon, Inc. | Methods of purifying authentic IGF from yeast hosts |
| US5789547A (en) * | 1995-06-07 | 1998-08-04 | Celtrix Pharmaceuticals, Inc. | Method of producing insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) with correct folding and disulfide bonding |
| US7193042B1 (en) | 1995-06-07 | 2007-03-20 | Chiron Corporation | Methods for purifying authentic IGF from yeast hosts |
| US6008013A (en) * | 1996-07-05 | 1999-12-28 | University Of Rochester | Chondrocyte proteins |
| KR20020074749A (ko) * | 2001-03-21 | 2002-10-04 | 한국생명공학연구원 | 재조합 인슐린 유사성장인자-1의 대량 생산방법 |
| EP1988154B1 (fr) * | 2007-04-30 | 2013-08-21 | Ajinomoto Co., Inc. | Procédé de fabrication de facteur de croissance de type insuline |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8303626D0 (sv) * | 1983-06-23 | 1983-06-23 | Kabigen Ab | A recombinant plasmid a transformant microorganism, a polydoxyrebonucleotide segment, a process for producing a biologically active protein, and the protein thus produced |
| WO1985000831A1 (fr) * | 1983-08-10 | 1985-02-28 | Amgen | Expression microbienne d'un facteur de croissance semblable a l'insuline |
| DE3537708A1 (de) * | 1985-10-23 | 1987-04-23 | Boehringer Mannheim Gmbh | Verfahren zur aktivierung von t-pa nach expression in prokaryonten |
| ATE86496T1 (de) * | 1988-02-05 | 1993-03-15 | Ciba Geigy Ag | Verwendung von igf i zur herstellung eines praeparates fuer die behandlung von nierenkrankheiten. |
| WO1990002815A1 (fr) * | 1988-09-13 | 1990-03-22 | The General Hospital Corporation | Isolation, purification et caracterisation des aminopeptidases mas ii et mas iii |
| DE3835350A1 (de) * | 1988-10-17 | 1990-04-19 | Boehringer Mannheim Gmbh | Aktivierung von gentechnologisch hergestellten, in prokaryonten exprimierten antikoerpern |
-
1993
- 1993-03-19 EP EP93907573A patent/EP0586667A1/fr not_active Withdrawn
- 1993-03-19 WO PCT/US1993/002457 patent/WO1993019084A1/fr not_active Application Discontinuation
- 1993-03-19 AU AU38129/93A patent/AU3812993A/en not_active Abandoned
- 1993-03-19 CA CA002109820A patent/CA2109820A1/fr not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO1993019084A1 (fr) | 1993-09-30 |
| AU3812993A (en) | 1993-10-21 |
| EP0586667A1 (fr) | 1994-03-16 |
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