CA2096933C - Compounds and compositions which inhibit bone resorption - Google Patents

Compounds and compositions which inhibit bone resorption Download PDF

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Publication number
CA2096933C
CA2096933C CA002096933A CA2096933A CA2096933C CA 2096933 C CA2096933 C CA 2096933C CA 002096933 A CA002096933 A CA 002096933A CA 2096933 A CA2096933 A CA 2096933A CA 2096933 C CA2096933 C CA 2096933C
Authority
CA
Canada
Prior art keywords
pthrp
bone resorption
inhibitory activity
amino acid
bone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002096933A
Other languages
English (en)
French (fr)
Other versions
CA2096933A1 (en
Inventor
Bruce E. Kemp
Geoffrey C. Nicholson
Thomas J. Martin
Anna J. Fenton
R. Glenn Hammonds
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Melbourne
Genentech Inc
Original Assignee
University of Melbourne
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Melbourne, Genentech Inc filed Critical University of Melbourne
Publication of CA2096933A1 publication Critical patent/CA2096933A1/en
Application granted granted Critical
Publication of CA2096933C publication Critical patent/CA2096933C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Transceivers (AREA)
  • Mobile Radio Communication Systems (AREA)
CA002096933A 1990-12-13 1991-12-13 Compounds and compositions which inhibit bone resorption Expired - Lifetime CA2096933C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
AUPK3879 1990-12-13
AUPK387990 1990-12-13
AUPK956791 1991-11-19
AUPK9567 1991-11-19
PCT/AU1991/000580 WO1992010511A1 (en) 1990-12-13 1991-12-13 Compounds and compositions which inhibit bone resorption

Publications (2)

Publication Number Publication Date
CA2096933A1 CA2096933A1 (en) 1992-06-14
CA2096933C true CA2096933C (en) 2003-05-13

Family

ID=25643990

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002096933A Expired - Lifetime CA2096933C (en) 1990-12-13 1991-12-13 Compounds and compositions which inhibit bone resorption

Country Status (12)

Country Link
US (1) US5688760A (show.php)
EP (1) EP0561877B1 (show.php)
JP (1) JP3280021B2 (show.php)
AT (1) ATE181336T1 (show.php)
AU (1) AU666838B2 (show.php)
CA (1) CA2096933C (show.php)
DE (1) DE69131355T2 (show.php)
DK (1) DK0561877T3 (show.php)
ES (1) ES2135398T3 (show.php)
GR (1) GR3030947T3 (show.php)
HU (1) HUT64565A (show.php)
WO (1) WO1992010511A1 (show.php)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2158762A1 (en) * 1993-04-08 1994-10-27 Hans Rink Cyclic compounds and compositions which inhibit bone resorption
GB9425582D0 (en) * 1994-12-19 1995-02-15 Iaf Biochem Int Peptides having immunomodulatory activity
AU691725B2 (en) * 1995-02-20 1998-05-21 Masahiro Iwamoto Therapeutics of osteoarthritis and inflammatory joint disease
DE69604936T2 (de) * 1995-03-20 2000-05-18 Shell Internationale Research Maatschappij B.V., Den Haag/S'gravenhage Verfahren zur regeneration von katalysatoren
EP0902036A1 (en) 1997-09-05 1999-03-17 Roche Diagnostics GmbH Peptide containing an arginine mimetic for the treatment of osteoporosis, their production, and drugs containing these compounds
AU757658B2 (en) * 1998-03-09 2003-02-27 Zealand Pharma A/S Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis
WO2003059291A2 (en) * 2002-01-10 2003-07-24 Osteotrophin Llc Treatment of bone disorders with skeletal anabolic drugs
EP1585535A2 (en) * 2002-08-15 2005-10-19 Osteotrophin LLC Pthrp-derived modulators of smooth muscle proliferation
WO2009033788A2 (en) * 2007-09-11 2009-03-19 Mondobiotech Laboratories Ag Use of a jck-301, optionally in combination with big endothelin, as a therapeutic agent.
ES2605813B1 (es) * 2015-09-16 2018-01-17 Fundación Instituto De Investigación Sanitaria Fundación Jiménez Díaz Uso de osteostatina en la preparación de un medicamento para el tratamiento de artrosis
US11858974B2 (en) * 2017-05-22 2024-01-02 Resq Biotech Macrocyclic modulators of disease associated protein misfolding and aggregation
WO2024238631A2 (en) * 2023-05-15 2024-11-21 Purdue Research Foundation A cytokine-like propeptide gene therapy platform

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL78342A (en) * 1985-04-04 1991-06-10 Gen Hospital Corp Pharmaceutical composition for treatment of osteoporosis in humans comprising a parathyroid hormone or a fragment thereof
JPS63259972A (ja) * 1987-04-17 1988-10-27 Fuji Electric Co Ltd 燃料電池設備
US5312810A (en) * 1987-05-20 1994-05-17 The University Of Melbourne Method and compositions for making ACSF and ACSF antagonists
JP2795657B2 (ja) * 1987-05-20 1998-09-10 ジェネンテク，インコーポレイテッド Ａｃｓｆおよびａｃｓｆアンタゴニストの製造方法および組成物
US4819504A (en) * 1987-05-27 1989-04-11 Sampson Sports, Inc. Self contained braking system for bicycle pedals
EP0341962B1 (en) * 1988-05-09 1995-03-15 Merck & Co. Inc. Humoral hypercalcemic factor antagonists
JP2752987B2 (ja) * 1988-06-01 1998-05-18 株式会社東芝 リン酸型燃料電池発電プラント

Also Published As

Publication number Publication date
ES2135398T3 (es) 1999-11-01
AU9063291A (en) 1992-07-08
EP0561877B1 (en) 1999-06-16
DK0561877T3 (da) 1999-12-27
ATE181336T1 (de) 1999-07-15
HUT64565A (en) 1994-01-28
EP0561877A1 (en) 1993-09-29
JPH06503330A (ja) 1994-04-14
CA2096933A1 (en) 1992-06-14
HU9301726D0 (en) 1993-10-28
EP0561877A4 (show.php) 1994-03-23
US5688760A (en) 1997-11-18
JP3280021B2 (ja) 2002-04-30
GR3030947T3 (en) 1999-11-30
DE69131355T2 (de) 1999-12-30
WO1992010511A1 (en) 1992-06-25
DE69131355D1 (de) 1999-07-22
AU666838B2 (en) 1996-02-29

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