CA2091292A1 - New derivatives of .beta.-amino acids - Google Patents

New derivatives of .beta.-amino acids

Info

Publication number
CA2091292A1
CA2091292A1 CA002091292A CA2091292A CA2091292A1 CA 2091292 A1 CA2091292 A1 CA 2091292A1 CA 002091292 A CA002091292 A CA 002091292A CA 2091292 A CA2091292 A CA 2091292A CA 2091292 A1 CA2091292 A1 CA 2091292A1
Authority
CA
Canada
Prior art keywords
amino
formula
denotes
group
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002091292A
Other languages
English (en)
French (fr)
Inventor
Georg Kottirsch
Rainer Metternich
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2091292A1 publication Critical patent/CA2091292A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pyridine Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA002091292A 1992-03-10 1993-03-09 New derivatives of .beta.-amino acids Abandoned CA2091292A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4207544.0 1992-03-10
DE4207544 1992-03-10

Publications (1)

Publication Number Publication Date
CA2091292A1 true CA2091292A1 (en) 1993-09-11

Family

ID=6453662

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002091292A Abandoned CA2091292A1 (en) 1992-03-10 1993-03-09 New derivatives of .beta.-amino acids

Country Status (26)

Country Link
US (1) US5561112A (enExample)
EP (1) EP0560730B1 (enExample)
JP (1) JP2860222B2 (enExample)
KR (1) KR930019690A (enExample)
CN (1) CN1076200A (enExample)
AT (1) ATE142618T1 (enExample)
AU (1) AU659281B2 (enExample)
CA (1) CA2091292A1 (enExample)
CZ (1) CZ36193A3 (enExample)
DE (1) DE69304573T2 (enExample)
DK (1) DK0560730T3 (enExample)
ES (1) ES2090934T3 (enExample)
FI (1) FI931023L (enExample)
GR (1) GR3021030T3 (enExample)
HU (2) HUT63609A (enExample)
IL (1) IL104972A (enExample)
MX (1) MX9301298A (enExample)
MY (1) MY109060A (enExample)
NO (1) NO300778B1 (enExample)
NZ (1) NZ247084A (enExample)
PH (1) PH30893A (enExample)
RU (1) RU2106356C1 (enExample)
SG (1) SG47059A1 (enExample)
SK (1) SK17093A3 (enExample)
TW (1) TW256828B (enExample)
ZA (1) ZA931724B (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750754A (en) * 1993-03-29 1998-05-12 Zeneca Limited Heterocyclic compounds
US5652242A (en) * 1993-03-29 1997-07-29 Zeneca Limited Heterocyclic derivatives
EP0690847A1 (en) * 1993-03-29 1996-01-10 Zeneca Limited Heterocyclic compounds as platelet aggregation inhibitors
US5753659A (en) * 1993-03-29 1998-05-19 Zeneca Limited Heterocyclic compouds
DK0691959T3 (da) * 1993-03-29 1999-04-26 Zeneca Ltd Heterocykliske derivater som blodpladeaggregations-inhibitorer
DE4310643A1 (de) * 1993-04-01 1994-10-06 Merck Patent Gmbh Cyclische Adhäsionsinhibitoren
GB9313268D0 (en) * 1993-06-28 1993-08-11 Zeneca Ltd Chemical compounds
US5463011A (en) * 1993-06-28 1995-10-31 Zeneca Limited Acid derivatives
GB9313285D0 (en) * 1993-06-28 1993-08-11 Zeneca Ltd Acid derivatives
US5811398A (en) * 1995-04-11 1998-09-22 G. D. Searle & Co. Platelet aggregation inhibitors containing C-terminal aminergic side chain amino acid residues
ES2186874T3 (es) * 1996-02-22 2003-05-16 Bristol Myers Squibb Pharma Co Analogos de m-amidinofenilo como inhibidores del factor xa.
US5942544A (en) * 1996-02-22 1999-08-24 Dupont Pharmaceuticals Company α-branched anilines, toluenes, and analogs thereof as factor Xa inhibitors
UA63887C2 (en) * 1996-10-28 2004-02-16 Lg Chemical Ltd Selective thrombin inhibitors and a pharmaceutical composition based thereon
US20050118101A1 (en) * 2002-01-28 2005-06-02 Olivier Loiseleur Beta-homolysine conjugates and their use as transport enhancer

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4578079A (en) * 1982-08-04 1986-03-25 La Jolla Cancer Research Foundation Tetrapeptide
CH673654A5 (enExample) * 1987-04-08 1990-03-30 Nippon Shinyaku Co Ltd
IT1222437B (it) * 1987-08-04 1990-09-05 Ellem Ind Farmaceutica Tripeptidi utili come immunostimolanti e nella prevenzione delle metastasi e relativo procedimento di preparazione
US5037808A (en) * 1988-07-20 1991-08-06 Monsanto Co. Indolyl platelet-aggregation inhibitors
US4879313A (en) * 1988-07-20 1989-11-07 Mosanto Company Novel platelet-aggregation inhibitors
US5039805A (en) * 1988-12-08 1991-08-13 Hoffmann-La Roche Inc. Novel benzoic and phenylacetic acid derivatives
US5273982A (en) * 1990-03-09 1993-12-28 Hoffmann-La Roche Inc. Acetic acid derivatives
CA2037153A1 (en) * 1990-03-09 1991-09-10 Leo Alig Acetic acid derivatives
US5354738A (en) * 1992-09-04 1994-10-11 G. D. Searle & Co. Platelet aggregation inhibitors

Also Published As

Publication number Publication date
KR930019690A (ko) 1993-10-18
CZ36193A3 (en) 1994-01-19
NO300778B1 (no) 1997-07-21
DK0560730T3 (da) 1996-10-28
RU2106356C1 (ru) 1998-03-10
ZA931724B (en) 1994-09-10
DE69304573T2 (de) 1997-03-20
FI931023A0 (fi) 1993-03-08
DE69304573D1 (de) 1996-10-17
EP0560730B1 (en) 1996-09-11
IL104972A (en) 1998-04-05
EP0560730A3 (en) 1993-12-01
HU9300501D0 (en) 1993-05-28
PH30893A (en) 1997-12-23
GR3021030T3 (en) 1996-12-31
HU210878A9 (en) 1995-09-28
NZ247084A (en) 1995-09-26
FI931023A7 (fi) 1993-09-11
AU659281B2 (en) 1995-05-11
CN1076200A (zh) 1993-09-15
MX9301298A (es) 1993-10-01
SG47059A1 (en) 1998-03-20
EP0560730A2 (en) 1993-09-15
TW256828B (enExample) 1995-09-11
ATE142618T1 (de) 1996-09-15
JP2860222B2 (ja) 1999-02-24
MY109060A (en) 1996-11-30
NO930830L (no) 1993-09-13
FI931023L (fi) 1993-09-11
ES2090934T3 (es) 1996-10-16
IL104972A0 (en) 1993-07-08
JPH0665175A (ja) 1994-03-08
HUT63609A (en) 1993-09-28
US5561112A (en) 1996-10-01
SK17093A3 (en) 1993-10-06
AU3406993A (en) 1993-09-16
NO930830D0 (no) 1993-03-08

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued