CA2069869C - Uncharged morpholino-based polymers having phosphorous-containing chiral intersubunit linkages - Google Patents

Uncharged morpholino-based polymers having phosphorous-containing chiral intersubunit linkages

Info

Publication number
CA2069869C
CA2069869C CA002069869A CA2069869A CA2069869C CA 2069869 C CA2069869 C CA 2069869C CA 002069869 A CA002069869 A CA 002069869A CA 2069869 A CA2069869 A CA 2069869A CA 2069869 C CA2069869 C CA 2069869C
Authority
CA
Canada
Prior art keywords
base
subunit
morpholino
polymer
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002069869A
Other languages
English (en)
French (fr)
Other versions
CA2069869A1 (en
Inventor
James E. Summerton
Dwight D. Weller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sarepta Therapeutics Inc
Original Assignee
Antivirals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Antivirals Inc filed Critical Antivirals Inc
Publication of CA2069869A1 publication Critical patent/CA2069869A1/en
Application granted granted Critical
Publication of CA2069869C publication Critical patent/CA2069869C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G79/00—Macromolecular compounds obtained by reactions forming a linkage containing atoms other than silicon, sulfur, nitrogen, oxygen, and carbon with or without the latter elements in the main chain of the macromolecule
    • C08G79/02—Macromolecular compounds obtained by reactions forming a linkage containing atoms other than silicon, sulfur, nitrogen, oxygen, and carbon with or without the latter elements in the main chain of the macromolecule a linkage containing phosphorus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Peptides Or Proteins (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Saccharide Compounds (AREA)
  • Polyamides (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002069869A 1989-12-20 1990-12-20 Uncharged morpholino-based polymers having phosphorous-containing chiral intersubunit linkages Expired - Lifetime CA2069869C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45405789A 1989-12-20 1989-12-20
US454,057 1989-12-20

Publications (2)

Publication Number Publication Date
CA2069869A1 CA2069869A1 (en) 1991-06-21
CA2069869C true CA2069869C (en) 1995-12-19

Family

ID=23803120

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002069869A Expired - Lifetime CA2069869C (en) 1989-12-20 1990-12-20 Uncharged morpholino-based polymers having phosphorous-containing chiral intersubunit linkages

Country Status (8)

Country Link
EP (2) EP0962463B1 (ja)
JP (2) JP3398378B2 (ja)
KR (1) KR0167574B1 (ja)
AT (2) ATE220407T1 (ja)
AU (1) AU655164B2 (ja)
CA (1) CA2069869C (ja)
DE (2) DE69034213T2 (ja)
WO (1) WO1991009033A1 (ja)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
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US5166315A (en) * 1989-12-20 1992-11-24 Anti-Gene Development Group Sequence-specific binding polymers for duplex nucleic acids
US5405938A (en) * 1989-12-20 1995-04-11 Anti-Gene Development Group Sequence-specific binding polymers for duplex nucleic acids
WO1998046740A1 (en) * 1997-04-17 1998-10-22 Antivirals, Inc. Method of treating restenosis by antisense targeting of cmv
US6365351B1 (en) * 1999-01-29 2002-04-02 Avi Biopharma, Inc. Non-invasive method for detecting target RNA
US20010024783A1 (en) * 1999-01-29 2001-09-27 Avi Biopharma, Inc. Non-invasive method for detecting target RNA
US6875747B1 (en) 1999-05-24 2005-04-05 Avi Bio Pharma, Inc. Antisense to c-myc for treatment of polycystic kidney disease
KR100708573B1 (ko) * 1999-05-24 2007-04-18 에이브이아이 바이오파마 인코포레이티드 다낭 신장 질환의 치료를 위한 ｃ-ｍｙｃ에 대한 안티센스
US6677153B2 (en) 1999-11-29 2004-01-13 Avi Biopharma, Inc. Antisense antibacterial method and composition
AU781676B2 (en) * 2000-01-04 2005-06-02 Avi Biopharma, Inc. Antisense antibacterial cell division composition and method
AU2005327188C8 (en) 2004-07-02 2011-09-22 Avi Biopharma, Inc. Antisense antibacterial method and compound
US8067571B2 (en) 2005-07-13 2011-11-29 Avi Biopharma, Inc. Antibacterial antisense oligonucleotide and method
SI2735568T1 (en) * 2006-05-10 2018-01-31 Sarepta Therapeutics, Inc. Analogues of the oligonucleotide, with cationic links between subunits
CN101861318A (zh) * 2007-11-15 2010-10-13 Avi生物制药公司 合成吗啉代低聚物的方法
NZ603606A (en) 2010-05-28 2015-06-26 Sarepta Therapeutics Inc Oligonucleotide analogues having modified intersubunit linkages and/or terminal groups
AU2013202731B2 (en) * 2010-05-28 2016-04-21 Sarepta Therapeutics, Inc. Oligonucleotide analogues having modified intersubunit linkages and/or terminal groups
TWI541024B (zh) 2010-09-01 2016-07-11 日本新藥股份有限公司 反義核酸
US10017763B2 (en) 2010-09-03 2018-07-10 Sarepta Therapeutics, Inc. dsRNA molecules comprising oligonucleotide analogs having modified intersubunit linkages and/or terminal groups
ES2607603T3 (es) 2010-09-30 2017-04-03 Nippon Shinyaku Co., Ltd. Derivado de ácido morfolino nucleico
KR20140097398A (ko) * 2011-11-18 2014-08-06 사렙타 쎄러퓨틱스, 인코퍼레이티드 기능적으로-변형된 올리고뉴클레오티드 및 이의 서브유니트
IN2014DN06220A (ja) 2011-12-28 2015-10-23 Nippon Shinyaku Co Ltd
US9920085B2 (en) * 2012-03-20 2018-03-20 Sarepta Therapeutics, Inc. Boronic acid conjugates of oligonucleotide analogues
EP3015467A4 (en) 2013-05-24 2016-11-02 Ajinomoto Kk PROCESS FOR THE PRODUCTION OF MORPHOLINO-OLIGONUCLEOTIDE
RU2702424C2 (ru) 2014-03-12 2019-10-08 Ниппон Синяку Ко., Лтд. Антисмысловые нуклеиновые кислоты
TWI721461B (zh) 2014-06-17 2021-03-11 日商日本新藥股份有限公司 反義核酸
EP3208277A4 (en) * 2014-10-14 2018-06-13 Ajinomoto Co., Inc. Morpholino oligonucleotide manufacturing method
JP6733554B2 (ja) 2015-01-21 2020-08-05 味の素株式会社 沈殿促進剤およびそれを用いる沈殿化方法
EP3302489A4 (en) 2015-06-04 2019-02-06 Sarepta Therapeutics, Inc. METHOD AND COMPOUNDS FOR THE TREATMENT OF DISEASES AND SUFFERING IN CONNECTION WITH LYMPHOCYTES
MY185390A (en) 2015-09-15 2021-05-17 Nippon Shinyaku Co Ltd Antisense nucleic acids
WO2017047741A1 (ja) 2015-09-16 2017-03-23 日本新薬株式会社 筋萎縮症治療用アンチセンス核酸
JP2019534862A (ja) * 2016-09-20 2019-12-05 ザ リージェンツ オブ ザ ユニヴァーシティ オブ コロラド，ア ボディ コーポレイト ホスホルアミダイト化学を使用する骨格修飾モルホリノオリゴヌクレオチド及びキメラの合成
JP7394749B2 (ja) 2018-05-10 2023-12-08 日本新薬株式会社 オリゴ核酸化合物の製造方法
KR20210023988A (ko) 2018-06-26 2021-03-04 니뽄 신야쿠 가부시키가이샤 안티센스 올리고뉴클레오티드를 함유하는 조성물 및 듀시엔형 근이영양증의 치료로의 그의 사용
GB201821269D0 (en) 2018-12-28 2019-02-13 Nippon Shinyaku Co Ltd Myostatin signal inhibitor
CA3161589A1 (en) 2019-11-13 2021-05-20 Nippon Shinyaku Co., Ltd. Method for producing oligonucleic acid compound
US20230018780A1 (en) 2019-11-13 2023-01-19 Nippon Shinyaku Co., Ltd. Method for producing oligonucleic acid compound
IL293997A (en) 2019-12-19 2022-08-01 Nippon Shinyaku Co Ltd Antistrand nucleic acids that allow exon skipping
CN114901823A (zh) 2019-12-26 2022-08-12 日本新药株式会社 诱导外显子50的跳读的反义核酸
KR20220145865A (ko) 2020-02-28 2022-10-31 니뽄 신야쿠 가부시키가이샤 엑손 51의 스키핑을 유도하는 안티센스 핵산
EP4320138A1 (en) 2021-04-09 2024-02-14 Bachem Holding AG Pseudo solid phase protecting group and methods for the synthesis of oligonucleotides and oligonucleotide conjugates
CA3218264A1 (en) 2021-04-28 2022-11-03 Nippon Shinyaku Co., Ltd. Method for producing oligonucleic acid compound
JPWO2022239863A1 (ja) 2021-05-13 2022-11-17
KR20240013202A (ko) 2021-05-28 2024-01-30 스미토모 파마 가부시키가이샤 안티센스 핵산
TW202307208A (zh) 2021-06-23 2023-02-16 日商日本新藥股份有限公司 反義寡聚物之組合
TW202308664A (zh) 2021-07-08 2023-03-01 日商日本新藥股份有限公司 腎毒性減輕劑
AU2022306542A1 (en) 2021-07-08 2024-01-18 Nippon Shinyaku Co., Ltd. Precipitation suppressing agent
WO2023282345A1 (ja) 2021-07-08 2023-01-12 日本新薬株式会社 腎毒性軽減剤
WO2023026994A1 (ja) 2021-08-21 2023-03-02 武田薬品工業株式会社 ヒトトランスフェリンレセプター結合ペプチド－薬物コンジュゲート

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE171185T1 (de) * 1985-03-15 1998-10-15 Antivirals Inc Immunotestmittel für polynukleotid und verfahren

Also Published As

Publication number Publication date
AU7164291A (en) 1991-07-18
EP0506830A4 (en) 1993-01-07
DE69033986T2 (de) 2003-03-13
ATE220407T1 (de) 2002-07-15
DE69033986D1 (de) 2002-08-14
EP0506830A1 (en) 1992-10-07
EP0506830B1 (en) 2005-12-14
CA2069869A1 (en) 1991-06-21
KR920703584A (ko) 1992-12-18
ATE312834T1 (de) 2005-12-15
DE69034213D1 (de) 2006-01-19
WO1991009033A1 (en) 1991-06-27
EP0962463B1 (en) 2002-07-10
KR0167574B1 (ko) 1999-01-15
DE69034213T2 (de) 2006-08-24
EP0962463A1 (en) 1999-12-08
JP2002167441A (ja) 2002-06-11
JP3398378B2 (ja) 2003-04-21
AU655164B2 (en) 1994-12-08
JPH05504563A (ja) 1993-07-15

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