KR20240013202A - 안티센스 핵산 - Google Patents

안티센스 핵산 Download PDF

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KR20240013202A
KR20240013202A KR1020237044656A KR20237044656A KR20240013202A KR 20240013202 A KR20240013202 A KR 20240013202A KR 1020237044656 A KR1020237044656 A KR 1020237044656A KR 20237044656 A KR20237044656 A KR 20237044656A KR 20240013202 A KR20240013202 A KR 20240013202A
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oligonucleotide
acceptable salt
pharmaceutically acceptable
base sequence
seq
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지치우 만
시게히로 아사노
교스케 히노
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스미토모 파마 가부시키가이샤
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Abstract

인간 WRN 유전자의 제26번 또는 제28번 엑손의 스킵변이에 대하여, 기능적인 인간 WRN 단백질을 발현하는 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염으로서, 상기 올리고뉴클레오티드는, 각 뉴클레오티드가 인산기 및/또는 수식 인산기로 결합되어 있고, 상기 올리고뉴클레오티드는, 적어도 1개의 수식 당을 가지는 수식 핵산을 포함하고, 상기 올리고뉴클레오티드의 염기길이는, 10∼30mer이며, 상기 올리고뉴클레오티드의 염기서열은, 서열번호 1, 서열번호 2, 서열번호 3, 서열번호 4, 서열번호 5, 또는 서열번호 6에 기재된 염기서열에서의, 상기 올리고뉴클레오티드와 동일한 염기길이로 구성된 적어도 1개의 표적 영역에 대하여 상보적인 염기서열을 기준으로 하여, 90% 이상 100% 이하의 서열동일성을 가지는 염기서열, 상기 표적 영역에 있어서 1개 또는 수개의 염기가 결실, 치환, 삽입 또는 부가 된 염기서열에 대하여, 상보적인 염기서열, 또는, 상기 표적 영역을 가지는 올리고뉴클레오티드에 대하여, 스트린젠트한 조건에서 하이브리다이징하는 염기서열인, 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염.

Description

안티센스 핵산
본 발명은, 베르너 증후군의 원인 유전자인 WRN 유전자의 제27번째의 엑손의 스킵핑(skipping)을 가능하게 하는 안티센스 올리고뉴클레오티드(안티센스 핵산) 및 상기 올리고뉴클레오티드를 포함하는 의약조성물에 관한 것이다.
베르너 증후군은, 조기노화를 초래하는 희소질환이며, 청년기에, 일반적인 노인에 나타나는 특징, 예를 들면, 백발화, 대머리, 당뇨병, 심장질환, 암, 피부의 퇴축(退縮), 피부의 강피증 유사 변화, 청년성 백내장, 조로증, 생식선 기능 저하 등을 나타내는 것으로 알려져 있다. 보다 구체적으로는, 20∼30세부터 피부의 위축·경화, 백발이나 대머리 등의 모발의 변화, 백내장 등의 노화 징후가 출현한다. 또한, 당뇨병, 동맥경화 및 악성종양 등을 높은 비율로 합병하여, 대부분 50세에 사망에 이른다. 또한, 팔꿈치, 무릎, 발뒤꿈치 등에 호발하는 난치성 피부궤양의 악화에 의해 사지절단에 이르러, 생활의 질이 저하되는 케이스도 많다(비특허문헌 1).
베르너 증후군은 상염색체열성의 유전성 희소질환이며, 제8염색체 단완(短腕)(8p12) 상에 존재하는 RecQ형 DNA/RNA헬리카제(WRN헬리카제)를 코딩하는 WRN 유전자가 원인 유전자로서 확인되고 있다(비특허문헌 2, 비특허문헌 3).
WRN 단백질은 1432아미노산으로 이루어지고, ATP의존성의 DNA/RNA헬리카제 활성, 3'→5'엑소뉴클레아제 활성을 가진다. 생리기능으로서는, DNA복제, 염기제거 수복, DNA이중가닥 절단 수복, 전사(轉寫), 텔로미어의 유지와 다양한 기능을 가지고, 유전자수복과 염색체의 안정성의 유지에 작용한다. 이에 따라 베르너 증후군에서는 현저한 게놈의 불안정화가 인정된다. 베르너 증후군 환자 유래 섬유아세포는, 정상인 유래의 정상세포와 비교하여 분열 수명이 짧고, 증식 속도가 현저하게 저하된다(비특허문헌 4). 섬유아세포분열능의 저하는, 베르너 증후군의 피부궤양의 창상치유의 지연의 하나의 요인인 것으로 여겨진다(비특허문헌 5).
WRN 단백질의 C말단부근에는 핵이행신호(NLS: Neuclear Localization Signal)가 존재하고, 핵이행을 유도함으로써 정상적인 생리기능을 행한다(도 1). 그러나, 스플라이싱, 넌센스, 프레임 시프트 등의 변이에 기초한 중도 스톱 코돈(종지 코돈)의 출현에 의해 핵이행신호가 결실한 불완전한 WRN 단백질이 만들어진 경우, 원래 핵내에서 기능해야 할 WRN헬리카제가 핵내로 이행할 수 없으므로, 그 기능을 행할 수 없게 되어, 베르너 증후군이 발증한다(도 1 및 도 2)(비특허문헌 3).
베르너 증후군의 일본인 환자의 약 7할에 있어서, 인간 WRN 유전자의 26번 엑손의 스킵변이 c.3139-1G>C에 의해 아미노산의 판독 틀에 어긋남이 생기고(Out-of-Frame), 제27번 엑손(이하, 「엑손 27」로 칭하는 경우가 있음) 에 스톱 코돈(종지 코돈)이 출현한다. 이 때문에 인간 WRN 유전자의 제27번 엑손 이후의 C말단에 존재하는 핵이행신호를 결실하고 있는 WRN 단백질이 만들어져, 본래의 기능을 상실한다(도 2)(비특허문헌 3).
국제공개 제2011/052436호 국제공개 제2014/046212호 국제공개 제2015/125783호 국제공개 제1991/009033호 국제공개 제2009/064471호
Geriatr Gerontol Int(2013) 13: 475-481 Nature(1992) 355: 735-738 Am. J. Hum. Genet.(1997) 60: 330-341 Human Genetics(1981) 58: 310-316 피부임상(2000) 40: 1512-1513 Annu. Rev. Pharmacol. Toxicol.(2010) 50: 259-293 J.Med.Chem.(2016) 59: 9645-9667 J.Am.Chem.Soc(2016) 138: 15663-15672
베르너 증후군은, 환자의 생명과 생활의 질을 위협하는 난병(불치병)이지만, 현재시점에서 베르너 증후군에 대한 유효한 치료법이 없고, 새로운 치료약의 창제가 절실하게 요망되고 있다.
최근, 새로운 치료약으로서 핵산의약품이 실용화되고 있다. 핵산의약품은, 핵산 혹은 수식 핵산이 십여 개에서 몇십 개의 염기로 연결된 올리고 핵산으로 구성되며, 단백질 번역에 영향을 미치는 메신저 RNA 또는 비번역 RNA 등에 직접 작용하는 것이나, 항체의약과 같이 표적단백질에 작용하는 것이 알려져 있고, 화학적 합성에 의해 제조되는 의약품이다. 핵산의약품의 일종인 스플라이싱 제어형 안티센스 올리고뉴클레오티드는, 스플라이싱 인자의 mRNA 전구체(이하, 「pre-mRNA」로 칭하는 경우가 있음)에 대한 결합을 저해함으로써, 근방에 존재하는 엑손의 스플라이싱을 스위칭하여(스플라이스 아웃), 프레임 시프트를 일으킨 이상(異常) RNA의 리딩프레임(reading frame)을 정상화할 수 있다. 그 결과, 어떤 유전자의 엑손을 스플라이스 아웃시킴으로써, 기능 발현에 중요한 N말단과 C말단을 유지한 상기 단백질을 발현시킨다. 이와 같이, 스플라이싱 제어형 안티센스 올리고뉴클레오티드에 의해 표적이 되는 엑손을 스킵함으로써 C말단까지 번역된 기능적인 단백질을 새롭게 발현시키는 것이 가능하게 되며, 이로써 어떤 질환의 병의 용태를 개선할 가능성이 있다. 이는, 엑손스킵요법으로 불리우며, 이 치료에 의해 발현되는 단백질은 정상보다 짧아지지만, 변이에 의해 결손하고 있던 기능을 회복할 수 있다(비특허문헌 6).
상기한 바와 같이, 베르너 증후군에 있어서 가장 고빈도의 변이으로서 보고된 것은, 인간 WRN 유전자의 제26번 엑손의 스킵변이 c.3139-1G>C이다. 상기 스킵변이 c.3139-1G>C에 의해 제27번 엑손 내에 종지 코돈이 출현하고, C말단에 존재하는 핵이행신호를 포함한 종지 코돈 이후의 아미노산서열을 결실한 WRN 단백질이 만들어져, 본래의 생리기능을 상실한다. 이 상태를 개선하기 위하여, 본 발명자들은, 스플라이싱 제어형 안티센스 올리고뉴클레오티드에 착안하고, 인간 WRN 유전자의 엑손 27의 스킵핑을 유도하는 안티센스 올리고뉴클레오티드의 창생의 검토를 행하였다.
본 발명은 상기한 사정을 감안하여 이루어 것이며, 본 발명이 해결하고자 하는 과제는, 인간 WRN 유전자의 제27번 엑손의 스킵핑을 가능하게 하는 올리고뉴클레오티드, 및 이것을 포함하는 인간 WRN 유전자의 제27번 엑손을 고효율로 스킵핑시키는 약제를 제공하는 것을 목적으로 한다.
본 발명자들은, 인간 WRN 유전자의 mRNA 전구체 중 엑손 27 및 주변의 뉴클레오티드로 이루어지는 서열을 안티센스 올리고뉴클레오티드로 타겟팅함으로써, 고효율로 엑손 27의 스킵핑을 유도할 수 있는 것을 발견하였다. 본 발명자들은, 이러한 지견에 기초하여, 본 발명을 완성시켰다. 즉, 본 발명은 하기와 같다.
[1] 본 발명에 따른 올리고뉴클레오티드는, 인간 WRN 유전자의 제26번 또는 제28번 엑손의 스킵변이에 대하여, 기능적인 인간 WRN 단백질을 발현하는 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염으로서,
상기 올리고뉴클레오티드는, 각 뉴클레오티드가 인산기 및/또는 수식 인산기로 결합되어 있고,
상기 올리고뉴클레오티드는, 적어도 1개의 수식 당을 가지는 수식 핵산을 포함하고,
상기 올리고뉴클레오티드의 염기길이는, 10∼30mer이며,
상기 올리고뉴클레오티드의 염기서열은,
서열번호 1, 서열번호 2, 서열번호 3, 서열번호 4, 서열번호 5, 또는 서열번호 6에 기재된 염기서열에서의, 상기 올리고뉴클레오티드와 동일한 염기길이로 구성된 적어도 1개의 표적 영역에 대하여 상보적(相補的)인 염기서열을 기준으로 하여, 90% 이상 100% 이하의 서열동일성을 가지는 염기서열,
상기 표적 영역에 있어서 1 또는 수 개의 염기가 결실, 치환, 삽입 또는 부가된 염기서열에 대하여, 상보적인 염기서열, 또는,
상기 표적 영역을 가지는 올리고뉴클레오티드에 대하여, 스트린젠트한 조건에서 하이브리다이징하는 염기서열인, 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염이다.
상기한 구성을 구비하는 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염은, 인간 WRN 유전자의 제27번 엑손의 스킵핑을 가능하게 한다.
[2] 상기 올리고뉴클레오티드의 염기서열은,
서열번호 1, 서열번호 2, 서열번호 3, 서열번호 4, 서열번호 5, 또는 서열번호 6에 기재된 염기서열에서의, 상기 올리고뉴클레오티드와 동일한 염기길이로 구성된 적어도 1개의 표적 영역에 대하여 상보적인 염기서열을 기준으로 하여, 95% 이상 100% 이하의 서열동일성을 가지는 염기서열인 것이 바람직하다.
[3] 상기 올리고뉴클레오티드의 염기서열은,
서열번호 1, 서열번호 2, 서열번호 3, 서열번호 4, 서열번호 5, 또는 서열번호 6에 기재된 염기서열에서의, 상기 올리고뉴클레오티드와 동일한 염기길이로 구성된 적어도 1개의 표적 영역에 대하여 상보적인 염기서열인 것이 바람직하다.
[4] 상기 올리고뉴클레오티드의 염기길이는, 15∼25mer인 것이 바람직하다.
[5] 상기 올리고뉴클레오티드를 구성하는 당이 D-리보퓨라노스이며, 당의 수식이 D-리보퓨라노스의 2'위치의 수산기의 당수식인 것이 바람직하다.
[6] 상기 올리고뉴클레오티드를 구성하는 당의 수식이 하기 식(A1)으로 표시되는 기인 것이 바람직하다.
(식 중, Bx는 핵산염기이며, 각각, 독립적으로, 아데닌, 구아닌, 시토신, 5-메틸시토신, 티민 또는 우라실로 표시되는 기이며, X는 인산 결합이며, 각각, 독립적으로, 포스포디에스테르 결합, 포스포로티오에이트 결합, 포스포로디티오에이트 결합, 포스포아미데이트 결합, 보라노포스페이트 결합 또는 알킬포스포네이트 결합이며, Y는, 각각, 독립적으로, 수소 원자, 수산기, 불소 원자, 치환되어 있어도 되는 탄소수 1∼6의 알콕시기, 또는 치환되어 있어도 되는 아미노기이며, Z는, 각각, 독립적으로, 수소 원자이거나, 탄소-산소 이중결합 또는 환상 구조를 가지고 있어도 되는 탄소수 1∼5의 알킬기이거나, 또는 상기 알킬기의 일부 탄소 원자와 Y가 합쳐져서 환을 형성한다.)
[7] 상기 올리고뉴클레오티드를 구성하는 당의 수식이 하기 식(A2) 또는 식(A3)으로 표시되는 기인 것이 바람직하다.
(식 중, Bx는 핵산염기이며, 각각, 독립적으로, 아데닌, 구아닌, 시토신, 5-메틸시토신, 티민 또는 우라실로 표시되는 기이며, X는 인산 결합이며, 각각, 독립적으로, 포스포디에스테르 결합, 포스포로티오에이트 결합, 포스포로디티오에이트 결합, 포스포아미데이트 결합, 보라노포스페이트 결합 또는 알킬포스포네이트 결합이며, R4는, 각각, 독립적으로, 수소 원자, 치환되어 있어도 되는 탄소수 1∼6의 알킬기이며, Y'는, 산소 원자 또는 치환되어 있어도 되는 질소 원자이며, R5 및 R6는, 각각, 독립적으로, 수소 원자, 치환되어 있어도 되는 탄소수 1∼6의 알킬기, 또는 R5 및 R6가 합쳐져서 카르보닐기 또는 환을 형성하고 있고, n은, 0 또는 1이다.)
[8] 상기 올리고뉴클레오티드를 구성하는 당의 수식이 상기 식(A2)으로 표시되는 기이며, 상기 R4는, 각각, 독립적으로, 메틸기, 메톡시에틸기, 또는 N-메틸프로판아미드기인 것이 바람직하다.
[9] 상기 올리고뉴클레오티드를 구성하는 당의 수식이 상기 식(A3)으로 표시되는 기이며, 상기 Y'는, 산소 원자, 또는 수소 원자, 메틸기, 메톡시에틸기, 혹은 N-메틸프로판아미드기에서 치환되어 있어도 되는 질소 원자이며, 상기 R5 및 R6는, 각각, 독립적으로, 수소 원자, 탄소수 1∼2의 알킬기, 또는 상기 R5 및 R6가 합쳐져서 카르보닐기 또는 탄소수 3∼6의 환을 형성하고 있고, n은, 0 또는 1인 것이 바람직하다.
[10] 상기 올리고뉴클레오티드 중 적어도 1개의 뉴클레오티드간 결합이 포스포로티오에이트 결합인 것이 바람직하다.
[11] 상기 올리고뉴클레오티드 중 적어도 1개의 뉴클레오티드간 결합이 포스포디에스테르 결합인 것이 바람직하다.
[12] 상기 올리고뉴클레오티드의 뉴클레오티드간 결합이 포스포디에스테르 결합 또는 포스포로티오에이트 결합인 것이 바람직하다.
[13] 상기 올리고뉴클레오티드의 염기서열은,
상기 올리고뉴클레오티드가 하기 식(A4)으로 표시되는 모르폴리노핵산으로 구성되며, 서열번호 1, 서열번호 2, 서열번호 3, 서열번호 4, 서열번호 5, 또는 서열번호 6에 기재된 염기서열에서의, 상기 올리고뉴클레오티드와 동일한 염기길이로 구성된 적어도 1개의 표적 영역에 대하여 상보적인 염기서열을 가지는 모르폴리노올리고핵산인 것이 바람직하다.
(식 중, Bx는 핵산염기이며, 각각, 독립적으로, 아데닌, 구아닌, 시토신, 5-메틸시토신, 티민 또는 우라실로 표시되는 기이며, X'는 인산 결합이며, 각각, 독립적으로, 포스포로디아미데이트 결합, 포스포로디아미드티오에이트 결합, 또는 포스포로디아미드디티오에이트 결합이다.)
[14] 상기 올리고뉴클레오티드의 염기서열은,
서열번호 1에 기재된 염기서열에 있어서, 5'말단으로부터 카운트하여 1번∼40번, 46번, 51번, 56번, 혹은 62번∼63번에 위치하는 염기로부터 연속된 15∼25mer로 구성된 표적 영역, 또는 서열번호 2에 기재된 염기서열에 있어서, 5'말단으로부터 카운트하여 108873번, 108878번∼108917번, 108923번, 108928번, 108933번, 혹은 108939번∼108940번에 위치하는 염기로부터 연속된 15∼25mer로 구성된 표적 영역에 대하여 상보적인 염기서열을 기준으로 하여, 90% 이상 100% 이하의 서열동일성을 가지는 염기서열,
상기 표적 영역에 있어서, 1개 또는 수개의 염기가 결실, 치환, 삽입 또는 부가된 염기서열에 대하여 상보적인 염기서열, 또는,
상기 표적 영역을 가지는 올리고뉴클레오티드에 대하여, 스트린젠트한 조건에서 하이브리다이징하는 염기서열인 것이 바람직하다.
[15] 상기 올리고뉴클레오티드의 염기서열은, 서열번호 1에 기재된 염기서열에 있어서, 5'말단으로부터 카운트하여 1번∼32번, 34번∼40번, 46번, 51번, 혹은 62번∼63번에 위치하는 염기로부터 연속된 15∼25mer로 구성된 표적 영역, 또는 서열번호 2에 기재된 염기서열에 있어서, 5'말단으로부터 카운트하여 108878번∼108909번, 108911번∼108917번, 108923번, 108928번, 혹은 08939번∼108940번에 위치하는 염기로부터 연속된 15∼25mer로 구성된 표적 영역에 대하여 상보적인 염기서열을 기준으로 하여, 90% 이상 100% 이하의 서열동일성을 가지는 염기서열인 것이 바람직하다.
[16] 상기 올리고뉴클레오티드의 염기서열은, 서열번호 1에 기재된 염기서열에 있어서, 5'말단으로부터 카운트하여 1번, 3번, 5번∼12번, 14번∼19번, 21번, 25번, 29번, 30번, 31번, 34번, 46번, 혹은 51번에 위치하는 염기로부터 연속된 15∼25mer로 구성된 표적 영역, 또는 서열번호 2에 기재된 염기서열에 있어서, 5'말단으로부터 카운트하여 108878번, 108880번, 108882번∼108889번, 108891번∼108896번, 108898번, 108902번, 108906번∼108908번, 108911번, 108923번, 혹은 108928번에 위치하는 염기로부터 연속된 15∼25mer로 구성된 표적 영역에 대하여 상보적인 염기서열을 기준으로 하여, 90% 이상 100% 이하의 서열동일성을 가지는 염기서열인 것이 바람직하다.
[17] 상기 올리고뉴클레오티드의 염기서열은, 서열번호 9∼14, 16∼26, 28∼39, 41∼42, 44∼50, 52, 55∼56, 69, 73, 80∼105, 107∼108, 110, 112, 114, 116, 118∼131, 133, 및 135의 염기서열로 이루어지는 군으로부터 선택되는 1개의 염기서열인 것이 바람직하다.
[18] 상기 올리고뉴클레오티드는, 표 2-1∼표 2-7에 나타낸 서열명 6-20-A, 8-20-A, 8-20-B, 8-20-C, 9-20-A,10-20-A, 12-20-A, 14-20-A, 16-20-A, 17-20-A, 18-20-A, 19-20-A, 15-25-A, 10-17-A, 10-20-B, 12-20-B, 14-20-B, 15-20-B, 16-20-B, 19-20-B, 31-20-B, 34-20-B, 6-20-B, 7-20-B, 8-20-D, 및 9-20-B로 이루어지는 군으로부터 선택되는 1개의 올리고뉴클레오티드인 것이 바람직하다.
[19] 상기 올리고뉴클레오티드는, 단일가닥 안티센스 올리고뉴클레오티드인 것이 바람직하다.
[20] 본 발명에 따른 이중가닥 안티센스 올리고뉴클레오티드는, 상기 [19]에 기재된 올리고뉴클레오티드와,
상기 단일가닥 안티센스 올리고뉴클레오티드에 대하여 하이브리다이징하고 있는 제2쇄 올리고뉴클레오티드를 포함하는 이중가닥 안티센스 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염이며,
상기 제2쇄 올리고뉴클레오티드의 염기서열은, 상기 단일가닥 안티센스 올리고뉴클레오티드의 염기서열에 대하여 상보적인 염기서열을 기준으로 하여, 90% 이상 100% 이하의 서열동일성을 가지는 염기서열인, 이중가닥 안티센스 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염이다.
[21] 본 발명에 따른 올리고뉴클레오티드 복합체는, 상기 [1]∼[19] 중 어느 하나에 기재된 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 또는 상기 [20]에 기재된 이중가닥 안티센스 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염과,
상기 올리고뉴클레오티드 또는 상기 제2쇄 올리고뉴클레오티드에, 직접 또는 링커 결합을 통하여 결합되어 있는 부가물질을 가지는, 올리고뉴클레오티드 복합체 또는 그의 제약학적으로 허용되는 염으로서,
상기 부가물질은, 폴리에틸렌글리콜, 펩티드, 알킬쇄, 리간드 화합물, 항체, 단백질, 및 당쇄로 이루어지는 군으로부터 선택되고,
상기 링커 결합은, 각각, 독립적으로 포스포디에스테르 결합, 포스포로티오에이트 결합, 포스포로디티오에이트 결합, 포스포아미데이트 결합, 보라노포스페이트 결합, 알킬포스포네이트 결합, 포스포로디아미데이트 결합, 포스포로디아미드티오에이트 결합, 또는 포스포로디아미드디티오에이트 결합인, 올리고뉴클레오티드 복합체 또는 그의 제약학적으로 허용되는 염이다.
[22] 본 발명에 따른 의약품은, 상기 [1]∼[19] 중 어느 하나에 기재된 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 상기 [20]에 기재된 이중가닥 안티센스 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 또는 상기 [21]에 기재된 올리고뉴클레오티드 복합체 또는 그의 제약학적으로 허용되는 염을 유효성분으로서 포함하는, 의약품이다.
[23] 본 발명에 따른 인간 WRN 유전자의 제27번째 엑손의 스킵핑제는, 상기 [1]∼[19] 중 어느 하나에 기재된 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 상기 [20]에 기재된 이중가닥 안티센스 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 또는 상기 [21]에 기재된 올리고뉴클레오티드 복합체 또는 그의 제약학적으로 허용되는 염을 유효성분으로서 포함하는, 인간 WRN 유전자의 제27번째 엑손의 스킵핑제이다.
[24] 본 발명에 따른 기능적 WRN 회복제는, 상기 [1]∼[19] 중 어느 하나에 기재된 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 상기 [20]에 기재된 이중가닥 안티센스 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 또는 상기 [21]에 기재된 올리고뉴클레오티드 복합체 또는 그의 제약학적으로 허용되는 염을 유효성분으로서 포함하는, 인간 WRN 유전자의 제27번째의 엑손의 스킵핑에 의한 핵이행신호를 보유하는 기능적 WRN 회복제이다.
[25] 본 발명에 따른 베르너 증후군에 대한 치료제는, 상기 [1]∼[19] 중 어느 하나에 기재된 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 상기 [20]에 기재된 이중가닥 안티센스 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 또는 상기 [21]에 기재된 올리고뉴클레오티드 복합체 또는 그의 제약학적으로 허용되는 염을 유효성분으로서 포함하는, 베르너 증후군에 대한 치료제이다.
[26] 본 발명에 따른 베르너 증후군에 대한 예방제는, 상기 [1]∼[19] 중 어느 하나에 기재된 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 상기 [20]에 기재된 이중가닥 안티센스 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 또는 상기 [21]에 기재된 올리고뉴클레오티드 복합체 또는 그의 제약학적으로 허용되는 염을 유효성분으로서 포함하는, 베르너 증후군에 대한 예방제이다.
[27] 본 발명에 따른 베르너 증후군의 치료 방법 또는 예방 방법은, 상기 [1]∼[19] 중 어느 하나에 기재된 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 상기 [20]에 기재된 이중가닥 안티센스 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 또는 상기 [21]에 기재된 올리고뉴클레오티드 복합체 또는 그의 제약학적으로 허용되는 염을 개체에 투여하는 것을 포함하는, 베르너 증후군의 치료 방법 또는 예방 방법이다.
[28] 본 발명은, 베르너 증후군의 치료 또는 예방에 사용하기 위한, 상기 [1]∼[19] 중 어느 하나에 기재된 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 상기 [20]에 기재된 이중가닥 안티센스 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 또는 상기 [21]에 기재된 올리고뉴클레오티드 복합체 또는 그의 제약학적으로 허용되는 염을 제공한다.
[29] 본 발명은, 베르너 증후군의 치료제 또는 예방제를 제조하기 위해 사용하는, 상기 [1]∼[19] 중 어느 하나에 기재된 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 상기 [20]에 기재된 이중가닥 안티센스 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 또는 상기 [21]에 기재된 올리고뉴클레오티드 복합체 또는 그의 제약학적으로 허용되는 염을 제공한다.
본 발명에 의하면, 인간 WRN 유전자의 제27번 엑손의 스킵핑을 가능하게 하는 올리고뉴클레오티드, 및 이것을 포함하는 인간 WRN 유전자의 제27번 엑손을 고효율로 스킵핑시키는 약제를 제공하는 것이 가능하게 된다.
도 1은, 인간 WRN 유전자산물의 구조를 나타낸 모식도이다.
도 2는, 26번 엑손의 스킵변이 c.3139-1G>C를 가지는 베르너 증후군의 발증 메커니즘을 설명하는 모식도이다.
도 3은, 본 실시형태에 따른 단일가닥 안티센스 올리고뉴클레오티드를 사용한 엑손 27의 스킵핑 메커니즘을 설명하는 모식도이다.
도 4는, WRN엑손 27의 스킵을 유도하도록 설계된 안티센스 올리고뉴클레오티드의 엑손 27에서의 상대적 위치를 나타낸 모식도이다.
도 5는, HEK293T에서의 WRN 유전자의 엑손 27의 스킵핑 효율을 나타내는 전기영동의 사진이다.
도 6은, 26번 엑손의 스킵변이 c.3139-1G>C를 가지는 베르너 증후군 환자 섬유아세포에서의 WRN 유전자의 엑손 27의 스킵핑 활성을 나타내는 전기영동의 사진이다.
도 7은, 26번 엑손의 스킵변이 c.3139-1G>C를 가지는 베르너 증후군 환자 섬유아세포에서의 WRN 유전자의 엑손 27의 스킵핑 활성을 나타내는 형광현미경의 관찰 화상이다.
≪인간 WRN 유전자의 제27번 엑손을 스킵핑시키는 올리고뉴클레오티드≫
본 실시형태의 올리고뉴클레오티드는,
인간 WRN 유전자의 제26번 또는 제28번 엑손의 스킵변이에 대하여, 기능적인 인간 WRN 단백질을 발현하는 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염으로서,
상기 올리고뉴클레오티드는, 각 뉴클레오티드가 인산기 및/또는 수식 인산기로 결합되어 있고,
상기 올리고뉴클레오티드는, 적어도 1개의 수식 당을 가지는 수식 핵산을 포함하고,
상기 올리고뉴클레오티드의 염기길이는, 10∼30mer이며,
상기 올리고뉴클레오티드의 염기서열은,
서열번호 1, 서열번호 2, 서열번호 3, 서열번호 4, 서열번호 5, 또는 서열번호 6에 기재된 염기서열에서의, 상기 올리고뉴클레오티드와 동일한 염기길이로 구성된 적어도 1개의 표적 영역에 대하여 상보적인 염기서열을 기준으로 하여, 90% 이상 100% 이하의 서열동일성을 가지는 염기서열,
상기 표적 영역에 있어서 1개 또는 수개의 염기가 결실, 치환, 삽입 또는 부가 된 염기서열에 대하여, 상보적인 염기서열, 또는,
상기 표적 영역을 가지는 올리고뉴클레오티드에 대하여, 스트린젠트한 조건에서 하이브리다이징하는 염기서열인, 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염이다. 상기 올리고뉴클레오티드는, 단일가닥 안티센스 올리고뉴클레오티드인 것이 바람직하다. 본 실시형태에 있어서, 용어 「수식 당을 가지는 수식 핵산」에는, 후술하는 모르폴리노핵산이 포함되는 것으로 한다.
상기 구성을 구비하는 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염은, 인간 WRN 유전자의 제27번 엑손의 스킵핑을 가능하게 한다. 본 실시형태의 일측면에 있어서, 상기 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염은, 「인간 WRN 유전자의 제27번 엑손을 스킵핑하는 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염」으로 파악할 수도 있다. 본 발명은, 인간 WRN 유전자의 제26번 엑손의 스킵변이 c.3139-1G>C에 의해 생긴 스플라이싱 이상에 기인하는, 아미노산 리딩프레임의 어긋난 mRNA 전구체에 대하여, 제27번 엑손의 스킵핑을 유도하여 리딩프레임의 어긋남을 해소함으로써, 난치성 피부궤양을 비롯한 베르너 증후군의 증상을 개선할 수 있다. 또한, 제26번 엑손의 스킵변이 c.3139-1G>C 이외로서, 예를 들면, 제26번 엑손의 스킵변이 c.3233＋1G>T, 제26번 엑손의 스킵변이 c.3233＋1G>C, 및 제28번 엑손의 스킵변이 c.IVS 28＋2T>C를 가지는 베르너 증후군 환자의 치료에도 응용 가능하다. 이하 상세하게 설명한다. 그리고, 본 실시형태에 따른 올리고뉴클레오티드를 편의 상 「안티센스 올리고뉴클레오티드」, 「단일가닥 안티센스 올리고뉴클레오티드」 등으로 표시하고 있는 경우가 있지만, 이들로 한정하는 것을 의도하는 것은 아니다.
<용어의 정의 등>
먼저, 본 명세서에 있어서 사용되는 용어의 정의 등에 대하여 이하에서 설명한다.
(WRN 유전자)
본 실시형태에 있어서 「WRN 유전자」는, NatuRe(1992)355: 735-738(비특허문헌 2), Am. J. Hum. Genet.(1997) 60: 330-341(비특허문헌 3)에 의해 정의할 수 있다.
(단일가닥 안티센스 올리고뉴클레오티드)
본 실시형태에 있어서 「단일가닥 안티센스 올리고뉴클레오티드」 또는 「안티센스 올리고뉴클레오티드」(이하, 「ASO」로 칭하는 경우가 있음)는, 표적유전자의 mRNA, mRNA 전구체, 또는 ncRNA(논코딩 RNA)(이하, 이들 ３자를 합쳐서 「표적 RNA」로 칭하는 경우가 있음)에 대하여 상보적인 올리고뉴클레오티드 또는 그의 약리학 상 허용되는 염을 의미한다. 안티센스 올리고뉴클레오티드는, DNA, RNA 및/또는 이들의 유사체로 구성된다. 안티센스 올리고뉴클레오티드는, 표적으로 하는mRNA, mRNA 전구체, 또는 ncRNA와 이중가닥을 형성함으로써, 표적으로 하는 mRNA, mRNA 전구체 또는 ncRNA의 움직임을 억제한다. 안티센스 올리고뉴클레오티드에는, 표적이 되는 mRNA, mRNA 전구체, 또는 ncRNA의 염기서열에 대하여, 완전히 상보적인 염기서열을 가지는 것, 상기 상보적인 염기서열에 있어서 1개 또는 수개의 염기가 결실, 치환, 삽입 또는 부가된 염기서열을 가지는 것, 및 동요 염기쌍을 형성하는 염기를 그 염기서열 중에 포함하는 것이 포함된다.
또한, 본 발명의 안티센스 올리고뉴클레오티드는, 후술하는 「당부가 수식 당인 수식 핵산」(당수식되어 있는 수식 뉴클레오티드) 이외의, 상기 분야에서 공지의 수식 뉴클레오티드를 더욱 포함해도 된다. 상기 분야에서 공지의 수식 뉴클레오티드로서는, 당수식되어 있는 수식 뉴클레오티드에 더하여, 예를 들면, 후술하는 인산기 수식되어 있는 수식 뉴클레오티드, 핵산염기 수식되어 있는 수식 뉴클레오티드 등이 있다.
그리고, 본 실시형태에서의 안티센스 올리고뉴클레오티드는, 그 양 말단의 구조는 특별히 제한되지 않으며, 예를 들면, -OH라도 되고, -OR(다만, R은 알킬쇄, 인산 에스테르체, 또는 후술하는 부가물질을 나타냄)이라도 된다.
또한, 본 실시형태에서의 단일가닥 안티센스 올리고뉴클레오티드는, 단일가닥의 형태라도 되고, 후술하는 제2쇄 올리고뉴클레오티드와 하이브리다이징하여 이중가닥의 형태를 가져도 된다. 상기 단일가닥 안티센스 올리고뉴클레오티드와, 상기 단일가닥 안티센스 올리고뉴클레오티드에 대하여 하이브리다이징하고 있는 제2쇄 올리고뉴클레오티드로 이루어지는 이중가닥 올리고뉴클레오티드를, 「이중가닥 안티센스 올리고뉴클레오티드」로 칭하는 경우가 있다.
(올리고뉴클레오티드)
본 실시형태에 있어서 「올리고뉴클레오티드」는, 동일하거나 또는 상이한 뉴클레오티드가, 인산 디에스테르 결합 또는 그 외의 결합으로 2∼30개 연결된 뉴클레오티드의 폴리머를 의미한다. 상기 올리고뉴클레오티드는, 하기 구조식으로 나타낸 바와 같이 핵산염기부, 인산부, 및 당부 또는 모르폴리노 환부(環部)로 구성되어 있는 것으로 파악할 수도 있다.
상기 올리고뉴클레오티드는, 천연형 올리고뉴클레오티드와 비천연형 올리고뉴클레오티드로 대별된다. 「천연 올리고뉴클레오티드」는 천연에 존재하고 있는 뉴클레오티드으로 이루어지는 올리고뉴클레오티드를 의미한다. 「비천연 올리고뉴클레오티드」는, 후술하는 수식 뉴클레오티드를 구성단위로서 적어도 1개 포함하는 올리고뉴클레오티드를 의미한다. 「비천연형 올리고뉴클레오티드」로서는, 바람직하게는, 당부가 수식된 수식 당유도체; 인산 디에스테르 결합의 비가교 산소 원자가 유황 원자로 1개 치환된 포스포로티오에이트 유도체; 인산 디에스테르 결합의 비가교 산소 원자가 유황 원자로 2개 치환된 포스포로디티오에이트 유도체; 인산 디에스테르 결합이 트리에스테르화된 에스테르 유도체; 인산 디에스테르 결합이 아미드화된 포스포아미드 유도체; 인산 디에스테르 결합이 붕소산 에스테르화된 보라노포스페이트유도체; 인산 디에스테르 결합의 비가교 산소 원자가 알킬기로 치환된 알킬포스포네이트(예를 들면, 메틸포스포네이트, 메톡시프로필포스포네이트 등) 유도체; 인산 디에스테르 결합이 아미드 결합에 치환된 아미드 유도체: 핵산염기가 수식된 수식 염기 유도체를 예로 들 수 있다. 더욱 바람직하게는, 상기 비천연 올리고뉴클레오티드는, 당부가 수식된 가교형 수식 당유도체; 인산 디에스테르 결합의 비가교 산소 원자가 유황 원자로 1개 치환된 포스포로티오에이트 유도체; 인산 디에스테르 결합이 에스테르화된 에스테르 유도체; 및 당부가 후술하는 수식 당(예를 들면, 가교형 당)으로 수식되고, 또한 인산 디에스테르 결합의 비가교 산소 원자가 유황 원자로 1개 치환되어 있거나, 또는 인산 디에스테르 결합의 비가교 산소 원자가 알킬기로 치환된 알킬 포스포네이트화되어 있는 유도체 등을 예로 들 수 있다.
(뉴클레오시드)
본 실시형태에 있어서 「뉴클레오시드」는, 퓨린 염기 또는 피리미딘 염기와 당이 결합한 화합물을 의미한다. 천연에 존재하고 있는 뉴클레오시드를 「천연 뉴클레오시드」라고 하는 경우가 있다. 천연에 존재하고 있지 않은 수식된 뉴클레오시드를 「수식 뉴클레오시드」라고 하는 경우가 있다. 특히 당부분이 수식된 수식 뉴클레오시드를 「수식 당 뉴클레오시드」라고 하는 경우가 있다.
(뉴클레오티드)
본 실시형태에 있어서 「뉴클레오티드」는, 상기 뉴클레오시드의 당에 인산기가 결합한 화합물을 의미한다. 천연에 존재하고 있는 뉴클레오티드를 「천연 뉴클레오티드」라고 하는 경우가 있다. 천연에 존재하고 있지 않은 수식된 뉴클레오티드를 「수식 뉴클레오티드」 또는 「수식 핵산」이라고 하는 경우가 있다. 「수식 뉴클레오티드」 또는 「수식 핵산」으로서는, 상기 수식 뉴클레오시드의 당부에 인산기가 결합한 화합물, 및 천연 뉴클레오시드의 당부에 후술하는 수식 인산기가 결합한 화합물 등을 예로 들 수 있다.
(당수식, 수식 당)
본 실시형태에 있어서 「당수식」은, 상기 뉴클레오티드의 당부가 수식되어 있는 것을 의미한다. 수식된 당부를 특히 「수식 당」이라고 하는 경우가 있다. 당수식이 실시되어 있는 수식 뉴클레오티드는 수식 핵산으로서 이용 가능하며, 예를 들면, 2'-O-알킬화 핵산, 2'-F화 핵산, 5'-메틸화 핵산, 2',4'-BNA(Bridged Nucleic Acid, 이하 「LNA」로 칭하는 경우가 있음), AmNA(아미드 가교형 인공 핵산, Amido-bridged nucleic acid), GuNA(구아니딘 가교형 인공핵산, Guanidino-bridged nucleic acid), scpBNA(2'-O,4'-C-SpiRocyclopRopylene bridged nucleic acid), ENA(2'-O,4'-C-Ethylene-Bridged Nucleic Acid), S-cEt(2',4'-constrained Ethyl Nucleic Acid) 등이 있다.
2'-O-알킬화 핵산으로서는, 예를 들면, 후술하는 기호 「A(M)」, 「A(m)」, 「C(M)」, 「5(m)」, 「G(M)」, 「G(m)」, 「U(M)」, 「T(m)」으로 표시되는 구조를 포함하는 것이 있다. LNA로서는, 예를 들면, 후술하는 기호 「A(L)」, 「5(L)」, 「G(L)」, 「T(L)」로 표시되는 구조를 포함하는 것이 있다. AmNA로서는, 예를 들면, 후술하는 기호 「A(Y)」, 「5(Y)」, 「G(Y)」, 「T(Y)」로 표시되는 구조를 포함하는 것이 있다. GuNA로서는, 예를 들면, 후술하는 기호 「A(Gx)」, 「5(Gx)」, 「G(Gx)」, 「T(Gx)」로 표시되는 구조를 포함하는 것이 있다. scpBNA로서는, 예를 들면, 후술하는 기호 「A(S)」, 「5(S)」, 「G(S)」, 「T(S)」로 표시되는 구조를 포함하는 것이 있다.
본 실시형태의 일측면에 있어서 상기 올리고뉴클레오티드를 구성하는 당의 수식이 하기 식(A1)으로 표시되는 기인 것이 바람직하다. 본 실시형태의 다른 측면에 있어서, 상기 올리고뉴클레오티드를 구성하는 수식 당이 하기 식(A1)으로 표시되는 것으로 파악할 수도 있다.
상기 식 중, Bx는 핵산염기이며, 각각, 독립적으로, 아데닌, 구아닌, 시토신, 5-메틸시토신, 티민 또는 우라실로 표시되는 기이며, X는 인산 결합이며, 각각, 독립적으로, 포스포디에스테르 결합, 포스포로티오에이트 결합, 포스포로디티오에이트 결합, 포스포아미데이트 결합, 보라노포스페이트 결합 또는 알킬포스포네이트 결합이며, Y는, 각각, 독립적으로, 수소 원자, 수산기, 불소 원자, 치환되어 있어도 되는 탄소수 1∼6의 알콕시기, 또는 치환되어 있어도 되는 아미노기이며, Z는, 각각, 독립적으로, 수소 원자인가, 탄소-산소 이중결합 또는 환상 구조를 가지고 있어도 되는 탄소수 1∼5의 알킬기이거나, 또는 상기 알킬기의 일부 탄소 원자와 Y가 합쳐져서 환을 형성한다. 여기서, 「탄소수 1∼5의 알킬기」는, 탄소수 1∼5의 알킬렌기의 일부 탄소 원자와 수소 원자가 합쳐져서 형성되는 1가의 기로 파악할 수도 있다.
「치환되어 있어도 되는 탄소수 1∼6의 알콕시기」로서는, 예를 들면, 치환되어 있지 않은 탄소수 1∼6의 알콕시기, 및 수산기, 불소 원자, 탄소수 1∼6의 직쇄형 또는 분지형 알콕시기, 탄소수 3∼8의 환상 알콕시기, 카르바모일기, 및 탄소수 1∼8의 알킬아미드기(-(CO)-NR7R8로 표시되는 기)로 이루어지는 군으로부터 선택되는 치환기로 치환되어 있는 탄소수 1∼6의 알콕시기가 있다. 여기서, R7 및 R8은, 각각, 독립적으로, 수소 원자, 또는 탄소수 1∼8의 직쇄형 또는 분지형 알킬기를 나타낸다.
「치환되어 있어도 되는 아미노기」로서는, 예를 들면, 치환되어 있지 않은 아미노기, 및 탄소수 1∼6의 직쇄형 또는 분지형 알킬기(상기 알킬기는, 탄소수 1∼6의 직쇄 또는 분지형 알콕시기, 또는 -(CO)-NR9R10로 표시되는 기로 치환되어 있어도 된다), 탄소수 3∼8의 환상 알킬기, 탄소수 1∼6의 아실기, 및 탄소수 1∼6의 직쇄형 또는 분지형 알킬기로 1∼3개소 치환되어 있는 아미딘기로 이루어지는 군으로부터 선택되는 치환기로 치환되어 있는 아미노기가 있다. 여기서, R9 및 R10은, 각각, 독립적으로, 수소 원자, 또는 탄소수 1∼6의 직쇄형 또는 분지형 알킬기를 나타낸다.
「탄소-산소 이중결합 또는 환상 구조를 가지고 있어도 되는 탄소수 1∼5의 알킬기」로서는, 예를 들면, 치환되어 있지 않은 탄소수 1∼5의 알킬기, 탄소-산소 이중결합을 가지고 있는 탄소수 1∼5의 알킬기, 및 탄소수 3∼5의 시클로알킬기(시클로프로필기 등)가 있다. 여기서, 「탄소-산소 이중결합을 가지고 있는 탄소수 1∼5의 알킬기」에서의 탄소수는, 탄소-산소 이중결합을 구성하고 있는 탄소가 포함되어 있어도 된다. 따라서, 본 실시형태에 있어서 「탄소-산소 이중결합을 가지고 있는 탄소수 1∼5의 알킬기」에는, 알데히드기가 포함될 수 있다. Z가 알데히드기이며, Y가 치환되어 있어도 되는 아미노기인 경우, Y와 Z에 의해 합쳐져서 형성되는 환은, 아미드 결합을 포함하는 구조라도 된다.
본 실시형태의 일측면에 있어서, 상기 올리고뉴클레오티드를 구성하는 당의 수식이 하기 식(A2) 또는 식(A3)으로 표시되는 기인 것이 바람직하다. 본 실시형태의 다른 측면에 있어서, 상기 올리고뉴클레오티드를 구성하는 수식 당이 하기 식(A2) 또는 식(A3)으로 표시되는 것으로 파악할 수도 있다.
식 중, Bx는 핵산염기이며, 각각, 독립적으로, 아데닌, 구아닌, 시토신, 5-메틸시토신, 티민 또는 우라실로 표시되는 기이며, X는 인산 결합이며, 각각, 독립적으로, 포스포디에스테르 결합, 포스포로티오에이트 결합, 포스포로디티오에이트 결합, 포스포아미데이트 결합, 보라노포스페이트 결합 또는 알킬포스포네이트 결합이며, R4는, 각각, 독립적으로, 수소 원자, 치환되어 있어도 되는 탄소수 1∼6의 알킬기이며, Y'는, 산소 원자 또는 치환되어 있어도 되는 질소 원자이며, R5 및 R6는, 각각, 독립적으로, 수소 원자, 치환되어 있어도 되는 탄소수 1∼6의 알킬기, 또는 R5 및 R6가 합쳐져서 카르보닐기 또는 환을 형성하고 있고, n은, 0 또는 1이다.
본 실시형태의 다른 측면에 있어서, 상기 올리고뉴클레오티드를 구성하는 당의 수식이 상기 식(A2)으로 표시되는 기이며, 상기 R4는, 각각, 독립적으로, 메틸기, 메톡시에틸기, 또는 N-메틸프로판아미드기(-CH2CH2-CONH-CH3, 메틸이미노카르보닐에틸기)인 것이 바람직하다.
본 실시형태의 다른 측면에 있어서, 상기 올리고뉴클레오티드를 구성하는 당의 수식이 상기 식(A3)으로 표시되는 기이며, 상기 Y'는, 산소 원자, 또는 수소 원자, 메틸기, 메톡시에틸기, 혹은 N-메틸프로판아미드기로 치환되어 있어도 되는 질소 원자이며, 상기 R5 및 R6는, 각각, 독립적으로, 수소 원자, 탄소수 1∼2의 알킬기, 또는 상기 R5 및 R6가 합쳐져서 카르보닐기 또는 탄소수 3∼6의 환을 형성하고 있고, n은, 0 또는 1인 것이 바람직하다.
(당수식 이외의 해당 분야에서 공지의 뉴클레오티드의 수식)
상기 당수식 이외의 해당 분야에서 공지의 뉴클레오티드의 수식은, 본 발명의 단일가닥 안티센스 올리고뉴클레오티드를 제조하기 위한 수식 핵산으로서 이용 가능하다. 뉴클레오티드의 수식으로서는, 후술하는 인산기 수식, 핵산염기 수식이 알려져 있다. 이와 같은 뉴클레오티드의 수식은, 예를 들면, J.Med.Chem.(2016) 59:9645-9667.(비특허문헌 5) 등에 기재되어 있는 뉴클레오티드의 수식이 있다. 이들 뉴클레오티드의 수식은, 상기 문헌에서 인용되고 있는 문헌에 있어서 설명되어 있는 해당 분야에서 공지의 방법에 기초하여 행할 수 있다.
(인산기)
본 실시형태에 있어서 「인산기」는, 상기 뉴클레오티드의 인산부의 결합 양식이 천연에 존재하는 포스포디에스테르 결합(후술하는 기호 「-」로 표시되는 결합)인 것을 의미한다.
(인산기 수식, 수식 인산기)
본 실시형태에 있어서 「인산기 수식」은, 상기 뉴클레오티드의 인산부가 수식되어 있는 것을 의미한다. 수식된 인산부를 특히 「수식 인산기」라고 하는 경우가 있다. 상기 수식 인산기를 포함하는 결합 양식으로서는, 예를 들면, 포스포로티오에이트 결합(후술하는 기호「Λ」로 나타내는 결합), 포스포로디티오에이트 결합, 포스포아미데이트 결합, 또는 보라노포스페이트 결합, 알킬포스포네이트 결합, 포스포로디아미데이트 결합(후술하는 기호「*」로 나타내는 결합), 포스포로디아미드티오에이트 결합, 및 포스포로디아미드디티오에이트 결합 등이 있다.
(핵산염기 수식, 수식 핵산염기)
본 실시형태에 있어서 「핵산염기 수식」이란, 상기 뉴클레오티드의 핵산염기부가 수식되어 있는 것을 의미한다. 수식된 핵산염기부를 특히 「수식 핵산염기」라고 하는 경우가 있다. 수식 핵산염기로서는, 예를 들면, 5-메틸시토신, 5-하이드록시메틸시토신, 5-프로피닐시토신 등이 있다.
(DNA 또는 RNA의 유사체)
상기 DNA 또는 RNA의 유사체와는, DNA 또는 RNA에 유사의 구조를 가지는 분자를 의미한다. 예를 들면, 펩티드 핵산(pNA), 모르폴리노핵산 등이 있다.
그리고, 본 발명에서 사용하는 핵산은, 핵산당부의 수식에 한정되지 않고, 모르폴리노핵산이나 펩티드 핵산을 사용해도 된다.
즉, 본 발명의 단일가닥 안티센스 올리고뉴클레오티드의 다른 일태양으로서는, 하기 <단일가닥 안티센스 올리고뉴클레오티드의 염기서열>의 란에 기재되는 서열에 있어서, 올리고뉴클레오티드는, DNA 또는 RNA의 유사체로 구성되어도 된다. 이 DNA 또는 RNA의 유사체는, 펩티드 핵산이나 모르폴리노핵산을 적어도 포함한다. 펩티드 핵산이나 모르폴리노핵산을 포함하는 본 발명의 안티센스 올리고뉴클레오티드의 합성은 일반적으로 정해진 방법에 따라 행한다. 모르폴리노올리고핵산은, 예를 들면, 국제공개 제1991/009033호(특허문헌 4), 국제공개 제2009/064471호(특허문헌 5), J.Am.Chem.Soc(2016) 138: 15663-15672(비특허문헌 8)에 따라 제조할 수 있다. 모르폴리노핵산으로서는, 예를 들면, 후술하는 기호 「A(N)」, 「C(N)」, 「G(N)」, 「T(N)」으로 표시되는 구조를 포함하는 것이 있다.
본 실시형태의 일측면에 있어서, 상기 올리고뉴클레오티드는, 하기 식(A4)으로 표시되는 모르폴리노핵산으로 구성되는 모르폴리노올리고핵산인 것이 바람직하다.
식 중, Bx는 핵산염기이며, 각각, 독립적으로, 아데닌, 구아닌, 시토신, 5-메틸시토신, 티민 또는 우라실로 표시되는 기이며, X'는 인산 결합이며, 각각, 독립적으로, 포스포로디아미데이트 결합, 포스포로디아미드티오에이트 결합, 또는 포스포로디아미드디티오에이트 결합이다.
(ncRNA)
본 실시형태에 있어서 「ncRNA」는, 단백질의 번역에는 관여하지 않는 RNA의 총칭을 의미한다. 상기 ncRNA로서는, 예를 들면, 리보솜 RNA, 전이 RNA, miRNA, Natural Antisense Transcript(NAT) 등이 있다.
(올리고뉴클레오티드의 핵산염기부)
상기 올리고뉴클레오티드의 핵산염기부로서는, 티미닐기, 시토시닐기, 아데니닐기, 구아니닐기, 5-메틸시토시닐기, 우라실릴기, 2-옥소-4-하이드록시-5-메틸-1,2-디하이드로피리미딘-1-일기, 2-옥소-4-아미노-1,2-디하이드로피리미딘-1-일기, 4-아미노-5-메틸-2-옥소-1,2-디하이드로피리미딘-1-일기, 및 2-옥소-4-하이드록시-1,2-디하이드로피리미딘-1-일 등을 예로 들 수 있다. 바람직하게는, 상기 핵산염기부로서는, 티미닐기, 시토시닐기, 아데니닐기, 구아니닐기, 5-메틸시토시닐기, 및 우라실릴기 등을 예로 들 수 있다. 상기 핵산염기 중, 우라실(U)과 티민(T)은, 호환성이 있다. 우라실(U)과 티민(T)의 어느 쪽도, 상보쇄인 아데닌(A)과의 염기쌍을 형성할 수 있다. 또한, 안티센스 올리고뉴클레오티드의 핵산염기부에 있어서도 동일하다.
(표적 RNA)
본 실시형태에 있어서 「표적 RNA」는, 상기 단일가닥 안티센스 올리고뉴클레오티드가 결합하는 RNA를 나타낸다. 바꾸어 말하면, 본 실시형태에 있어서 표적 RNA는, WRN 유전자의 mRNA 전구체를 의미한다. 상기 표적 RNA로서는, 예를 들면, 서열번호 2에 기재된 염기서열을 가지는 인간 WRN 유전자의 mRNA 전구체, 서열번호 3∼5 중 어느 하나에 기재된 염기서열을 가지는 인간 WRN 유전자의 엑손 26 스킵변이를 가지는 mRNA 전구체, 서열번호 6에 기재된 염기서열을 가지는 인간 WRN 유전자의 엑손 28 스킵변이를 가지 는mRNA 전구체기 있다.
(표적 RNA와의 결합)
본 실시형태에 있어서 「표적 RNA와의 결합」은, 단일가닥 안티센스 올리고뉴클레오티드의 핵산염기가, 표적 RNA와의 상보성에 의해, 상기 표적 RNA의 핵산염기와 함께 이중가닥핵산을 형성하는 것을 의미한다. 상기 이중가닥핵산은, 상기 표적 RNA 중 적어도 일부에 있어서 형성되어 있으면 된다. 그리고, 상기 표적 RNA와의 결합의 강도는, 예를 들면, 열안정성의 지표에 의해 측정할 수 있다. 상기 열안정성의 지표로서는, 예를 들면, 상기 이중가닥핵산의 융해 온도(Tm값) 등이 있다. 상기 Tm값으로서는, 바람직하게는 40∼90℃이며, 보다 바람직하게는 50∼70℃다.
(표적 영역)
상기 표적 영역은, WRN 유전자의 mRNA 전구체에서의, 상기 단일가닥 안티센스 올리고뉴클레오티드와 결합하는 영역을 의미한다. 상기 표적 영역에는, 표시된 염기서열로 이루어지는 표적 영역, 및 WRN의 mRNA 전구체 상의 영역을 포함한다.
(mRNA 전구체)
상기 mRNA 전구체는, DNA로부터 전사(轉寫)된 RNA의 1차전사물을 의미한다. 즉, 상기 mRNA 전구체는, 엑손 영역, 인트론 영역 및 비번역 영역(Untranslated region: UTR)을 포함하는 RNA이다. 상기 mRNA 전구체는, 전사 후 스플라이싱이 행해지기 전의 RNA로 파악할 수도 있다. 상기 mRNA 전구체가 스플라이싱되면 mRNA가 된다.
(표적 영역과의 결합)
상기 표적 영역과의 결합은, 본 발명의 단일가닥 안티센스 올리고뉴클레오티드가 표적 영역과 이중가닥을 형성하는 것을 의미한다. 다만, 본 발명의 단일가닥 안티센스 올리고뉴클레오티드는, 반드시 표적 영역 전체와 이중가닥을 형성할 필요는 없고, 표적 영역의 일부 영역과 이중가닥을 형성하는 것이면 된다. 즉, 본 발명의 단일가닥 안티센스 올리고뉴클레오티드는, 표적 영역과 완전한 상보성을 가지고 있는 것이 바람직하지만, WRN의 표적 영역과 결합하는 한, 표적 영역 중 적어도 일부 영역과 상보적이면 된다.
(표적 영역의 일부)
상기 표적 영역의 일부는, 표적 영역 중 10∼15 뉴클레오티드 염기길이의 영역을 의미한다.
(표적 영역 중 적어도 일부와 상보적)
상기 표적 영역 중 적어도 일부와 상보적이라는 것은, 표적 RNA 상의 표적 영역 중 적어도 일부 영역의 염기와 상보적인 것을 의미한다. 여기에서, 적어도 일부 영역에 대응하는 mRNA 전구체 상의 영역의 염기와 상보적인 것도 포함한다.
본 발명자들은, 스플라이싱 제어형 안티센스 올리고뉴클레오티드에 착안하여, 인간 WRN 유전자의 엑손 27의 스킵핑을 유도하는 안티센스 올리고뉴클레오티드의 창생의 검토를 행하였다.
<단일가닥 안티센스 올리고뉴클레오티드의 설계>
프레임 시프트 등에 의한 이상 RNA에 대하여, 단일가닥 안티센스 올리고뉴클레오티드는 이상이 된 리딩프레임을 원상태로 되돌리는 것을 가능하게 하고, 또한 표적 영역인 엑손을 스킵핑시키기 위한 화합물이다. 이에 따라, 안티센스 올리고뉴클레오티드의 구조로서는, 표적 RNA의 표적 영역에 결합할 수 있도록 설계되어 있고, 부가하여, RNaseH 등의 뉴클레아제로 인식되지 않도록 당부 수식 핵산이 배치되어 있다.
<단일가닥 안티센스 올리고뉴클레오티드의 염기서열>
본 실시형태에 따른 단일가닥 안티센스 올리고뉴클레오티드의 염기서열은,
(A) 서열번호 1에 기재된 염기서열에 있어서, 5'말단으로부터 카운트하여 1번∼40번, 46번, 51번, 56번, 혹은 62번∼63번에 위치하는 염기로부터 연속된 10∼30mer(바람직하게는15∼25mer)로 구성된 표적 영역, 또는 서열번호 2에 기재된 염기서열에 있어서, 5'말단으로부터 카운트하여 108873번, 108878번∼108917번, 108923번, 108928번, 108933번, 혹은 108939번∼108940번에 위치하는 염기로부터 연속된 15∼25mer로 구성된 표적 영역에 대하여 상보적인 염기서열을 기준으로 하여, 90% 이상 100% 이하의 서열동일성을 가지는 염기서열,
(B) 상기 표적 영역에 있어서, 1개 또는 수개의 염기가 결실, 치환, 삽입 또는 부가된 염기서열에 대하여, 상보적인 염기서열, 또는,
(C) 상기 표적 영역을 가지는 올리고뉴클레오티드에 대하여, 스트린젠트한 조건에서 하이브리다이징하는 염기서열인 것이 바람직하다.
또한, 본 실시형태에 있어서, 배열표에 나타나 있는 각염기서열은 핵산염기부의 배열 정보만을 나타내기 위해 사용하지만나 되므로 한다.
상기 핵산염기부에 더하여 당부 및 인산부를 포함시킨 올리고뉴클레오티드의 구조정보는, 후술하는 표 2-1∼표 2-7에 표시된 기재 형식으로 나타낸 것으로 한다.
본 실시형태에 있어서 「서열동일성」이란, 해당 기술 분야에 있어서 공지의 수학적 알고리즘을 사용하여 2개의 염기서열을 정렬시킨 경우의 최적 얼라인먼트(바람직하게는, 상기 알고리즘은 최적 얼라인먼트를 위하여 서열의 한쪽 또는 양쪽으로의 갭의 도입을 고려할 수 있는 것이다.)에서의, 오버랩하는 전체염기서열에 대한 동일염기의 비율(%)을 의미한다. 염기서열의 「서열동일성」은, 당업자라면 용이하게 확인할 수 있다. 예를 들면, NCBI BLAST(National Center for Biotechnology Information Basic Local Alignment Search Tool)를 사용할 수 있다.
본 실시형태에 따른 단일가닥 안티센스 올리고뉴클레오티드의 염기서열은, 서열번호 1에 기재된 염기서열에서의 전술한 소정의 표적 영역에 대하여 상보적인 염기서열과 95% 이상 100% 이하의 서열동일성을 가지는 것이 바람직하고, 98% 이상 100% 이하의 서열동일성을 가지는 것이 보다 바람직하고, 100%의 서열동일성을 가지는 것이 더욱 바람직하다.
본 실시형태에 있어서, 「1개 또는 수개의 염기가 결실, 치환, 삽입 또는 부가 된 염기서열」로서는, 예를 들면, 결실, 치환, 삽입 또는 부가에 의해, 결실, 치환, 삽입 또는 부가 되기 전의 염기서열에 대하여 80% 이상, 85% 이상, 90% 이상, 95% 이상, 97% 이상, 98% 이상, 또는 99% 이상의 서열동일성을 가지는 염기서열이다. 「1개 또는 수개의 염기」의 구체적인 수로서는, 전술한 결실, 치환, 삽입 또는 부가가, 각각 독립적으로, 1개소, 2개소, 3개소, 4개소, 또는 5개소에 존재해도 되고, 복수가 조합하여 일어나고 있어도 된다.
본 실시형태에 있어서 「스트린젠트한 조건」이란, 6×SSC(1×SSC의 조성: 0.15M의 NaCl, 0.015M의 시트르산 나트륨, pH 7.0)와 0.5% SDS와 5×덴하르트와 100μg/mL의 변성 연어 정자 DNA와 50%(v/v) 포름아미드를 포함하는 용액 중, 실온에서 12시간 인큐베이팅하고, 나아가서는 0.5×SSC로 50℃ 이상의 온도에서 세정하는 조건을 일컫는다. 또한, 보다 스트린젠트한 조건, 예를 들면, 45℃ 또는 60℃에서 12시간 인큐베이팅하는 것, 0.2×SSC 또는 0.1×SSC로 세정하는 것, 세정 시에 60℃ 또는 65℃ 이상의 온도 조건에서 세정하는 것 등의, 보다 엄격한 조건도 포함한다.
본 실시형태의 일측면에 있어서, 상기 단일가닥 안티센스 올리고뉴클레오티드의 염기서열은, 서열번호 1에 기재된 염기서열에 있어서, 5'말단으로부터 카운트하여 1번∼40번, 46번, 51번, 56번, 혹은 62번∼63번에 위치하는 염기로부터 연속된 15∼25mer로 구성된 표적 영역, 또는 서열번호 2에 기재된 염기서열에 있어서, 5'말단으로부터 카운트하여 108873번, 108878번∼108917번, 108923번, 108928번, 108933번, 혹은 108939번∼108940번에 위치하는 염기로부터 연속된 15∼25mer로 구성된 표적 영역에 대하여 상보적인 염기서열인 것이 바람직하다.
본 실시형태의 일측면에 있어서, 상기 단일가닥 안티센스 올리고뉴클레오티드의 염기서열은, 서열번호 1에 기재된 염기서열에 있어서, 5'말단으로부터 카운트하여 1번∼32번, 34번∼40번, 46번, 51번, 혹은 62번∼63번에 위치하는 염기로부터 연속된 15∼25mer로 구성된 표적 영역, 또는 서열번호 2에 기재된 염기서열에 있어서, 5'말단으로부터 카운트하여 108878번∼108909번, 108911번∼108917번, 108923번, 108928번, 혹은 108939번∼108940번에 위치하는 염기로부터 연속된 15∼25mer로 구성된 표적 영역에 대하여 상보적인 염기서열인 것이 보다 바람직하다.
본 실시형태의 일측면에 있어서, 상기 단일가닥 안티센스 올리고뉴클레오티드의 염기서열은, 서열번호 1에 기재된 염기서열에 있어서, 5'말단으로부터 카운트하여 1번, 3번, 5번∼12번, 14번∼19번, 21번, 25번, 29번, 30번, 31번, 34번, 46번, 혹은 51번에 위치하는 염기로부터 연속된 15∼25mer로 구성된 표적 영역, 또는 서열번호 2에 기재된 염기서열에 있어서, 5'말단으로부터 카운트하여 108878번, 108880번, 108882번∼108889번, 108891번∼108896번, 108898번, 108902번, 108906번∼108908번, 108911번, 108923번, 혹은 108928번에 위치하는 염기로부터 연속된 15∼25mer로 구성된 표적 영역에 대하여 상보적인 염기서열인 것이 보다 바람직하다.
상기 단일가닥 안티센스 올리고뉴클레오티드는, WRN 유전자의 표적 영역과 결합할 수 있다. 본 명세서에 있어서, 본 발명의 단일가닥 안티센스 올리고뉴클레오티드의 「WRN 유전자의 표적 영역과의 결합」은, 본 발명의 단일가닥 안티센스 올리고뉴클레오티드의 WRN의 mRNA 전구체로의 직접 결합을 포함한다.
본 발명의 단일가닥 안티센스 올리고뉴클레오티드의 일태양으로서는, WRN 유전자의 엑손 27을 스킵핑할 수 있는 단일가닥 안티센스 올리고뉴클레오티드이며, 표 1-1∼표 1-4에 기재되어 있는 어느 하나의 염기서열을 가지고, 상기 단일가닥 올리고뉴클레오티드는, 인간 WRN 유전자의 mRNA 전구체에서의 표적 영역과 상보적이다.
그리고, 상기 단일가닥 안티센스 올리고뉴클레오티드는, 표 1-1∼표 1-4에 기재되어 있는 염기서열을 포함하고 있으면 3'측 및/또는 5'측에 각각 1∼5 염기 연장되어 있어도 된다. 상기 표적 영역은, 인간 WRN의 mRNA 전구체에 있어서, 특히, 인간 WRN 유전자의 발현조절과 관련된 영역(예를 들면, 안티센스뉴클레오티드가 결합하기 쉬운 mRNA의 2차구조를 가지는 영역)이라고 할 수 있다. 예를 들면, 표 1-1에 있어서 서열번호 1의 5'말단위치가 「5」이며 3'말단위치가 「24」인 경우, 서열번호 1(서열번호 2의 엑손 27에 해당)에 기재된 염기서열에서의 5'말단으로부터 카운트하여 5번째로부터 24번째까지의 연속하는 20mer의 염기서열이, 대응하는 단일가닥 안티센스 올리고뉴클레오티드(서열명 「5-20」)가 표적으로 하는 인간 WRN의 엑손 27에서의 표적 영역이 된다. 또한, 표 1-1에 있어서 서열번호 1의 5'말단위치가 「(-)5」이며 3'말단위치가 「15」인 경우, 서열번호 1(서열번호 2의 엑손 27에 해당)에 기재된 염기서열에서의 5'말단에 결합하는 인트론 영역에 대하여 엑손 27에 결합하는 위치로부터 카운트하여 5번째의 염기로부터 엑손 27의 15번째까지의 20mer의 염기서열이, 대응하는 단일가닥 안티센스 올리고뉴클레오티드(서열명 「(-)5-20」)가 표적으로 하는 인간 WRN의 엑손 27에서의 표적 영역이 된다.
[표 1-1]
[표 1-2]
[표 1-3]
[표 1-4]
상기 표 1-1∼표 1-4에 있어서, 기호 「A'」, 기호 「C'」, 기호 「G'」 및 기호 「T'」는, 각각 천연 뉴클레오시드(후술하는, a, c, g, 및 t) 또는 수식 뉴클레오시드(수식 당 뉴클레오시드를 포함함)로부터 선택된다. 그리고, 수식 당 뉴클레오시드 중 2'-O-알킬화 핵산으로서는, 기호 「A'」는, 후술하는 A(M), 또는 A(m)으로부터 선택되고, 기호 「C'」는, 후술하는 C(M), 또는 5(m)으로부터 선택되고, 기호 「G'」는, 후술하는 G(M), 또는 G(m)으로부터 선택되고, 기호 「T'」는, 후술하는 U(M), 또는 T(m)으로부터 선택된다. 가교형 수식 뉴클레오시드로서는, 기호 「A'」는, 후술하는 A(L), A(Y), A(Gx), 또는 A(S)로부터 선택되고, 기호 「C'」는, 후술하는 5(x), 5(L), 5(Y), 5(Gx), 또는 5(S)로부터 선택되고, 기호 「G'」는, 후술하는 G(L), G(Y), G(Gx), 또는 G(S)로부터 선택되고, 기호 「T'」는, 후술하는 T(L), T(Y), T(Gx), 또는 T(S)로부터 선택된다. 모르폴리노핵산으로서는, 기호 「A'」는, 후술하는 A(N)이며, 기호 「C'」는, 후술하는 C(N)이며, 기호 「G'」는, 후술하는 G(N)이며, 기호 「T'」는, 후술하는 T(N)이다.
<약리학 상 허용되는 염>
본 실시형태에 따른 단일가닥 안티센스 올리고뉴클레오티드는, 약리학 상 허용되는 염의 형태라도 된다. 여기서, 「약리학 상 허용되는 염」은, 본 발명의 단일가닥 안티센스 올리고뉴클레오티드의 염이며, 본 발명의 단일가닥 안티센스 올리고뉴클레오티드의 생리학적으로 허용되는 염, 즉 상기 단일가닥 안티센스 올리고뉴클레오티드의 원하는 생물학적인 활성을 유지하고, 동시에 원하지 않는 독물학적 효과를 유지하지 않는 염을 의미한다. 그리고, 후술하는 이중가닥 안티센스 올리고뉴클레오티드 및 안티센스 올리고뉴클레오티드 복합체에 대해서도 동일하다.
<제약학적으로 허용되는 염>
본 실시형태의 일측면에 있어서, 상기 단일가닥 안티센스 올리고뉴클레오티드는, 제약학적으로 허용되는 염의 형태라도 된다. 여기서 「제약학적으로 허용되는 염」이란, 전술한 약리학 상 허용되는 염이며 또한 산부가염 또는 염기부가염인 것을 의미한다. 산부가염으로서는, 예를 들면, 염산염, 브롬화수소산염, 황산염, 요오드화수소산염, 질산염 및 인산염 등의 무기산염, 및 시트르산염, 옥살산염, 프탈산염, 푸마르산염, 말레산염, 숙신산염, 말산염, 아세트산염, 포름산염, 프로피온산염, 벤조산염, 트리플루오로아세트산염, 메탄술폰산염, 벤젠술폰산염, para-톨루엔술폰산염 및 캠퍼술폰산염 등의 유기산염이 있다. 또한, 염기부가염으로서는, 예를 들면, 나트륨염, 칼륨염, 칼슘염, 마그네슘염, 바륨염 및 알루미늄염 등의 무기염기염, 및 트리메틸아민, 트리에틸아민, 피리딘, 피콜린, 2,6-루티딘, 에탄올아민, 디에탄올아민, 트리에탄올아민, 트로메타민[트리스(하이드록시메틸)메틸아민], tert-부틸아민, 시클로헥실아민, 디시클로헥실아민 및 N,N-디벤질에틸아민 등의 유기염기염 등이 있다. 나아가서는, 알기닌, 리진(lysine), 오루니친, 아스파라긴산 또는 글루타민산(Glutamicacid)등의 염기성 아미노산 또는 산성 아미노산과의 염(아미노산염)을 들 수 있다.
그리고, 후술하는 이중가닥 안티센스 올리고뉴클레오티드 및 안티센스 올리고뉴클레오티드 복합체에 대하여도 같다.
<단일가닥 안티센스 올리고뉴클레오티드의 구조>
본 실시형태에 따른 단일가닥 안티센스 올리고뉴클레오티드는, 천연 올리고뉴클레오티드 및/또는 비천연 올리고뉴클레오티드에 의해 구성되어 있다. 상기 단일가닥 안티센스 올리고뉴클레오티드는, 단일가닥의 형태인 것이 바람직하다. 본 실시형태의 일측면에 있어서, 상기 단일가닥 안티센스 올리고뉴클레오티드는, 후술하는 제2쇄 올리고뉴클레오티드와 하이브리다이징하여 이중가닥의 형태(이중가닥 안티센스 올리고뉴클레오티드)를 가져도 된다. 상기 제2쇄 올리고뉴클레오티드의 염기서열은, 상기 단일가닥 안티센스 올리고뉴클레오티드의 염기서열에 대하여 상보적인 염기서열을 기준으로 하여, 90% 이상 100% 이하의 서열동일성을 가지는 염기서열인 것이 바람직하다.
<단일가닥 안티센스 올리고뉴클레오티드에 의한 엑손 스킵핑 기구>
상기 단일가닥 안티센스 올리고뉴클레오티드는, 이하의 메커니즘으로, 이상 스플라이싱된 표적 RNA의 리딩프레임을 원래의 리딩프레임으로 되돌리고, 기능적인 WRN 단백질의 발현을 유도한다. 엑손은 양쪽의 스플라이싱 부위가 스플라이소좀 복합체에 의해 인식된 경우에만 mRNA에 포함되지만, 스플라이싱 부위를 안티센스 올리고뉴클레오티드으로 타겟팅함으로써, 스플라이싱이 저해되어, 엑손 스킵핑을 유도할 수 있다. 엑손 스킵핑은, 엑손의 5'스플라이싱 부위 및 3'스플라이싱 부위 중 어느 한쪽 또는 양쪽, 또는 엑손의 내부를 표적으로 하는 단일가닥 안티센스 올리고뉴클레오티드가 상기 엑손에 결합함으로써 유도할 수 있다. 즉, 상기 단일가닥 안티센스 올리고뉴클레오티드가 표적 RNA의 표적 영역에 결합하고, 상기 엑손의 스플라이싱을 저해함으로써, 대상이 되는 엑손을 스킵시키는 것이 가능하게 되고, 발현된 mRNA를 바탕으로 기능적인 단백질의 번역을 유도한다.
또한, 상기 단일가닥 안티센스 올리고뉴클레오티드는, 본 실시형태에 있어서는, 상술한 바와 같은 메커니즘으로 인간 WRN 유전자의 제27번째의 엑손을 고효율로 스킵핑(WRN의 mRNA 전구체의 성숙을 조절하는 것을 통하여 작용하는 경우도 포함함)하기 위하여 바람직하게 사용하는 것이 가능하다. 보다 구체적으로는, 상기 단일가닥 안티센스 올리고뉴클레오티드가 표적 RNA(WRN 유전자의 mRNA 전구체)의 표적 영역인 엑손 27에 결합하여(도 3의 상단(上段)), 상기 엑손 27의 스플라이싱을 저해한다. 따라서, 베르너 증후군 환자에서 관찰되는 엑손 26의 스킵변이로 출현한 엑손 27 내의 종결 코돈이 스킵되고, 엑손 25와 엑손 28이 연결한 WRN mRNA(정상인 WRN 유전자의 리딩프레임으로 수정: 인·프레임)가 생성하고(도 3 중단), 상기 mRNA를 바탕으로 엑손 34에 포함되는 핵이행신호를 가지는 기능적인 WRN 단백질이 번역된다. 또한 본 실시형태에 의하면, 임상응용 시에 통상 사용되는 투여 경로인 경피투여, 정맥내 투여나 피내 투여에 있어서도, 상기 단일가닥 안티센스 올리고뉴클레오티드에 의한 기능적인 WRN 유전자의 발현을 조절하는 효과가 발휘될 수 있다. 여기서, 「인간 WRN 유전자의 제27번째의 엑손을 고효율로 스킵핑」이란, 인간 WRN 유전자의 제27번째의 엑손을 고효율로 스킵핑하는 것을 적어도 의미하고, 결과로서, 기능적인 WRN 단백질의 발현을 회복하는 것을 적어도 의미한다.
당부가 데옥시리보오스인 천연 뉴클레오티드로서는, 예를 들면, 데옥시아데노신 1인산, 데옥시구아노신 1인산, 티미딘 1인산, 데옥시시티딘 1인산, 디옥시-5-메틸시티딘 1인산 등이 있다. 바꾸어 말하면, 상기 단일가닥 안티센스 올리고뉴클레오티드를 구성하는 천연 뉴클레오티드로서는, 후술하는 기호 a, g, t, c 및 5(x) 각각에 대응하는 구조식을 포함하는 것을 예로 들 수 있다.
당부가 데옥시리보오스인 비천연 뉴클레오티드로서는, 예를 들면, 2-티오-티미딘-인산, 2-아미노아데노신-인산, 7-데아자구아노신-인산 등을 들 수 있다.
본 발명의 단일가닥 안티센스 올리고뉴클레오티드의 염기길이는, 10∼30mer이며, 바람직하게는 15∼25mer이며, 보다 바람직하게는 18∼22mer이며, 더욱 바람직하게는 16∼20mer이며, 특히 바람직하게는 18∼20mer이다. 본 발명의 단일가닥 안티센스 올리고뉴클레오티드의 염기길이가, 15∼25mer, 18∼22mer, 16∼20mer, 18∼20mer인 경우, 특히, WRN의 mRNA 전구체로의 결합이 강하고, 인간 WRN 유전자의 제27번째의 엑손에서의 고효율의 스킵핑을 보다 효과적으로 조절할 수 있다.
본 실시형태에 있어서, 상기 단일가닥 안티센스 올리고뉴클레오티드는, 각 뉴클레오티드가 인산기 및/또는 수식 인산기로 결합되어 있고, 포스포디에스테르 결합 또는 포스포로티오에이트 결합으로 결합되어 있는 것이 바람직하다.
<이중가닥 안티센스 올리고뉴클레오티드>
본 실시형태에 따른 이중가닥 안티센스 올리고뉴클레오티드는, 상기 단일가닥 안티센스 올리고뉴클레오티드와, 상기 단일가닥 안티센스 올리고뉴클레오티드에 대하여 하이브리다이징하고 있는 제2쇄 올리고뉴클레오티드를 포함하는 이중가닥 안티센스 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염이다. 상기 제2쇄 올리고뉴클레오티드의 염기서열은, 상기 단일가닥 안티센스 올리고뉴클레오티드의 염기서열에 대하여 상보적인 염기서열을 기준으로 하여, 90% 이상 100% 이하의 서열동일성을 가지는 염기서열인 것이 바람직하다.
상기 이중가닥 안티센스 올리고뉴클레오티드는, 용액 중에서 분해하고, 상기 단일가닥 안티센스 올리고뉴클레오티드와, 상기 제2쇄 올리고뉴클레오티드에 분리할 수 있다. 분리한 상기 단일가닥 안티센스 올리고뉴클레오티드는, 전술한 표적 RNA에 결합할 수 있다. 그리고, 상기 단일가닥 안티센스 올리고뉴클레오티드는, 상기 제2쇄 올리고뉴클레오티드와의 관계에 있어서, 「제1쇄 올리고뉴클레오티드」로 파악할 수도 있다. 그리고, 상기 이중가닥 안티센스 올리고뉴클레오티드를 구성하는 올리고뉴클레오티드 중 상기 제1쇄 올리고뉴클레오티드가 전술한 표적 RNA에 대한 안티센스 쇄를 가지고 있지만, 상기 제1쇄 올리고뉴클레오티드와 상기 제2쇄 올리고뉴클레오티드로 이루어지는 이중가닥 올리고뉴클레오티드를 편의 상 「이중가닥 안티센스 올리고뉴클레오티드」로 칭하기로 한다.
≪단일가닥 안티센스 올리고뉴클레오티드의 제조 방법≫
본 발명의 단일가닥 안티센스 올리고뉴클레오티드는, 포스포로아미다이트법에 의한 고상(固相)합성에 의해 제조할 수 있다. 예를 들면, 시판하고 있는 핵산자동합성기를 사용하여 고상담체 상에서 소정의 염기서열을 가지는 단일가닥 올리고뉴클레오티드를 먼저 합성한다. 다음으로, 염기성물질 등을 사용하여 고상담체로부터 합성한 단일가닥 올리고뉴클레오티드를 잘라내고, 탈(脫)보호를 행하고, 조체(粗體)인 단일가닥 올리고뉴클레오티드를 얻는다. 그 후, 얻어진 조체인 단일가닥 올리고뉴클레오티드를, HPLC 등을 사용하여 정제한다. 전술한 제조법으로 한정되지 않고, 본 발명의 단일가닥 안티센스 올리고뉴클레오티드는, 당업자에게 공지의 방법에 준하여, 핵산의 염기서열, 수식 부위 등을 적절하게 변경함으로써 제조할 수 있다. 또한, AmNA, GuNA, 및 scpBNA에 대해서는, 각각 국제공개 제2011/052436호(특허문헌 1), 국제공개 제2014/046212호(특허문헌 2), 및 국제공개 제2015/125783호(특허문헌 3)에 기재된 방법에 의해 제조할 수 있다. 또한, 모르폴리노올리고핵산(PMO)은, 국제공개 제1991/009033호(특허문헌 4), 국제공개 공보 제2009/064471호(특허문헌 5) 또는 비특허문헌 8에 기재된 방법에 따라 제조할 수 있다.
≪이중가닥 안티센스 올리고뉴클레오티드의 제조 방법≫
본 발명의 이중가닥 안티센스 올리고뉴클레오티드는, 먼저, 상기 단일가닥 안티센스 올리고뉴클레오티드와 동일한 제조 방법을 사용하여, 상기 단일가닥 안티센스 올리고뉴클레오티드에 상보적인 염기서열을 기준으로 하여 소정의 서열동일성을 가지는 올리고뉴클레오티드(제2쇄 올리고뉴클레오티드)를 제조한다. 그 후, 상기 단일가닥 안티센스 올리고뉴클레오티드 및 상기 제2쇄 올리고뉴클레오티드를 하이브리다이징시킴으로써 제조할 수 있다.
≪안티센스 올리고뉴클레오티드 복합체≫
본 실시형태에 따른안티센스 올리고뉴클레오티드 복합체는,
상기 올리고뉴클레오티드(바람직하게는, 단일가닥 안티센스 올리고뉴클레오티드) 또는 그의 제약학적으로 허용되는 염, 또는 상기 이중가닥 안티센스 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염과,
상기 올리고뉴클레오티드 또는 상기 제2쇄 올리고뉴클레오티드에 결합되어 있는 부가물질을 가진다.
상기 부가물질은, 폴리에틸렌글리콜, 펩티드, 알킬쇄(예를 들면, 포화지방족 탄화수소 등), 리간드 화합물, 항체, 단백질, 및 당쇄(예를 들면, 탄수화물, 다당 등)로 이루어지는 군으로부터 선택된다.
본 실시형태의 일측면에 있어서, 상기 올리고뉴클레오티드 복합체는, 상기 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 또는 상기 이중가닥 안티센스 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염과,
상기 올리고뉴클레오티드 또는 상기 제2쇄 올리고뉴클레오티드에, 직접 또는 링커 결합을 통하여 결합되어 있는 부가물질을 가지는, 올리고뉴클레오티드 복합체 또는 그의 제약학적으로 허용되는 염이며,
상기 부가물질은, 폴리에틸렌글리콜, 펩티드, 알킬쇄, 리간드 화합물, 항체, 단백질, 및 당쇄로 이루어지는 군으로부터 선택되고,
상기 링커 결합은, 각각, 독립적으로 포스포디에스테르 결합, 포스포로티오에이트 결합, 포스포로디티오에이트 결합, 포스포아미데이트 결합, 보라노포스페이트 결합, 알킬포스포네이트 결합, 포스포로디아미데이트 결합, 포스포로디아미드티오에이트 결합, 또는 포스포로디아미드디티오에이트 결합이다.
본 실시형태의 일측면에 있어서, 상기 안티센스 올리고뉴클레오티드 복합체는,
상기 올리고뉴클레오티드(바람직하게는단일가닥 안티센스 올리고뉴클레오티드) 또는 그의 제약학적으로 허용되는 염과,
상기 올리고뉴클레오티드에 결합되어 있는 부가물질을 가지고, 상기 부가물질은, 폴리에틸렌글리콜, 펩티드, 알킬쇄, 리간드 화합물, 항체, 단백질, 및 당쇄로 이루어지는 군으로부터 선택된다.
본 실시예의 다른 측면에 있어서, 상기 안티센스 올리고뉴클레오티드 복합체는,
상기 이중가닥 안티센스 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염과,
상기 단일가닥 안티센스 올리고뉴클레오티드 또는 상기 제2쇄 올리고뉴클레오티드에 결합되어 있는 부가물질을 가지고, 상기 부가물질은, 폴리에틸렌글리콜, 펩티드, 알킬쇄(예를 들면, 포화지방족 탄화수소 등), 리간드 화합물, 항체, 단백질, 및 당쇄(예를 들면, 탄수화물, 다당 등)로 이루어지는 군으로부터 선택된다.
본 실시형태에 있어서 「부가물질」이란, 상기 단일가닥 안티센스 올리고뉴클레오티드 또는 상기 제2쇄 올리고뉴클레오티드에 결합되어 있는 물질로서, 소정의 작용을 부여하기 위해 사용되는 물질을 의미한다. 상기 부가물질은, 상기 단일가닥 안티센스 올리고뉴클레오티드의 5'말단에 결합하고 있어도 되고, 3'말단에 결합하고 있어도 되고, 5'말단 및 3'말단의 양쪽에 결합하고 있어도 된다. 또한, 상기 부가물질은, 상기 제2쇄 올리고뉴클레오티드의 5'말단에 결합하고 있어도 되고, 3'말단에 결합하고 있어도 되고, 5'말단 및 3'말단의 양쪽에 결합하고 있어도 된다. 본 실시형태의 일측면에 있어서, 상기 부가물질은, 상기 단일가닥 안티센스 올리고뉴클레오티드 또는 상기 제2쇄 올리고뉴클레오티드의 5'말단 또는 3'말단 중 어느 한쪽에 결합되어 있는 것이 바람직하다. 또한, 상기 부가물질은, 상기 단일가닥 안티센스 올리고뉴클레오티드 또는 상기 제2쇄 올리고뉴클레오티드와 직접, 공유결합으로 결합하고 있어도 된다. 상기 부가물질은, 상기 단일가닥 안티센스 올리고뉴클레오티드 또는 상기 제2쇄 올리고뉴클레오티드와, 링커 물질을 통하여 결합하고 있어도 된다. 상기 링커 물질로서는, 예를 들면, 알킬, 폴리에틸렌글리콜, 펩티드, 디술피드, 인산 결합 등 및/또는 이들의 조합에 의해 구성된 링커가 있다. 상기 링커 물질은, 링커 결합으로 파악할 수도 있다.
상기 부가물질로서 사용되는 펩티드로서는, 예를 들면, 이하와 같은 것이 있지만, 이들로 제한하지 않는다. CPPs(Cell Penetrating Peptides: 세포막투과성 펩티드), 핵이행성 펩티드, TAT(TRans-Activator of Transcription protein), 폴리알기닌, 글루카곤상 펩티드-1 유사 펩티드, 합성환상 RGD 펩티드, 피부투과성 펩티드.
상기 부가물질로서 사용되는 리간드 화합물로서는, 예를 들면, 이하와 같은 것이 있지만, 이들로 제한하지 않는다. N-아세틸갈락토사민(GalNAc), 당류(글루코오스, 만노스 등), 지질류(콜레스테롤 등), 비타민류(엽산, 비타민 A, 비타민 E 등), 아미노산.
상기 부가물질로서 사용되는 항체로서는, 예를 들면, 이하와 같은 것을 들 수 있지만, 이들로 제한하지 않는다. 항(抗)인슐린 수용체 항체, 항트랜스페린수용체 항체, 항LDL수용체 관련 단백질항체, 항CD22항체, 항CD30항체, 항HER2항체.
상기 부가물질로서 사용되는 단백질로서는, 예를 들면, 이하와 같은 것이 있지만, 이것으로 제한하지 않는다. 알부민.
모르폴리노올리고핵산에 있어서, 상기 부가물질과 상기 링커 물질의 조합으로서는, 예를 들면, 이하의 구조식으로 나타내지는 것이 있지만, 이것으로 제한하지 않는다.
≪인간 WRN 유전자의 제27번째의 엑손의 스킵핑제≫
본 실시형태에 따른 인간 WRN 유전자의 제27번째의 엑손의 스킵핑제는, 본 발명의 단일가닥 안티센스 올리고뉴클레오티드, 상기 이중가닥 안티센스 올리고뉴클레오티드 또는 상기 안티센스 올리고뉴클레오티드 복합체를 유효성분으로서 포함한다.
본 발명의 단일가닥 안티센스 올리고뉴클레오티드는, WRN의 mRNA 전구체에 결합함으로써, 인간 WRN 유전자의 제27번째의 엑손을 스킵핑할 수 있다. 상기 스킵핑제의 투여 방법 및 제제는, 상기 분야에서 공지의 투여 방법 및 제제라면, 모두 사용 가능하다.
≪기능적 WRN 회복제≫
본 실시형태에 따른 기능적 WRN 회복제는, 상기 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 상기 이중가닥 안티센스 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 또는 상기 올리고뉴클레오티드 복합체 또는 그의 제약학적으로 허용되는 염을 유효성분으로서 포함하는, 인간 WRN 유전자의 제27번째의 엑손의 스킵핑에 의한 핵이행신호를 보유하는 기능적 WRN 회복제이다. 본 발명의 단일가닥 안티센스 올리고뉴클레오티드는, WRN의 mRNA 전구체에 결합함으로써, 인간 WRN 유전자의 제27번째의 엑손을 스킵핑할 수 있다. 특히, 상기 인간 WRN 유전자가 베르너 증후군 환자에서 관찰되는 엑손 26의 스킵변이를 가지는 경우, 상기 인간 WRN 유전자에서 출현한 엑손 27 내의 종결 코돈이 스킵되고, 엑손 25와 엑손 28이 연결한 WRN mRNA가 생성하고, 상기 mRNA를 바탕으로 엑손 34에 포함되는 핵이행신호를 가지는 기능적인 WRN 단백질이 번역된다.
≪단일가닥 안티센스 올리고뉴클레오티드 등을 유효성분으로서 함유하는 의약조성물≫
본 실시형태에 따른 의약조성물은, 본 발명의 단일가닥 안티센스 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 상기 이중가닥 안티센스 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 또는 상기 안티센스 올리고뉴클레오티드 복합체 또는 그의 제약학적으로 허용되는 염을 유효성분으로서 포함한다. 본 실시형태의 의약조성물의 투여 방법 및 제제는, 상기 분야에서 공지의 투여 방법 및 제제라면, 모두 이용 가능하다. 이하, 상기 의약조성물을, 「안티센스 올리고뉴클레오티드 등의 의약조성물」로 표기하는 경우가 있다.
상기 의약조성물은, 베르너 증후군의 치료 또는 예방에 사용된다. 달리 말하면, 상기 의약조성물은, 인간 WRN 유전자의 제27번째의 엑손을 고효율로 스킵핑함으로써 베르너 증후군의 증상의 개선을 기대할 수 있는 치료 또는 예방에 사용할 수 있다.
≪베르너 증후군에 대한 치료제 및 예방제≫
본 실시형태에 따른 베르너 증후군에 대한 치료제는, 상기 단일가닥 안티센스 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 상기 이중가닥 안티센스 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 또는 상기 안티센스 올리고뉴클레오티드 복합체 또는 그의 제약학적으로 허용되는 염을 유효성분으로서 포함한다. 본 실시형태에 따른 베르너 증후군에 대한 예방제는, 상기 단일가닥 안티센스 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 상기 이중가닥 안티센스 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 또는 상기 안티센스 올리고뉴클레오티드 복합체 또는 그의 제약학적으로 허용되는 염을 유효성분으로서 포함한다.
<개체>
본 발명에서의 개체와는, 포유동물을 의미한다. 바람직하게는, 인간, 원숭이, 마모셋, 개, 돼지, 토끼, 모르모트, 랫 및 마우스이다. 보다 바람직하게는 인간이다.
본 발명의 단일가닥 안티센스 올리고뉴클레오티드 또는 그의 의약조성물(베르너 증후군에 대한 치료제 및 예방제를 포함함)을 투여하는 데 있어서는, 그 투여 방법 및 제형은 특별히 한정되지 않는다. 즉, 상기 분야에서의 공지의 투여 방법 및 제제라면, 모두 본 발명의 안티센스 올리고뉴클레오티드 등의 투여 방법 및 제제로서 사용할 수 있다. 투여 방법으로서는, 예를 들면, 경구투여, 비경구투여 등이 있다. 비경구투여로서는, 점안투여, 질내투여, 직장내투여, 비강내투여, 경피투여, 정맥내 주사, 점적, 피하투여, 복강내투여 또는 근육내 주입, 흡인 또는 흡입에 의한 폐투여, 수강(髓腔)내투여, 뇌실내투여 등을 들 수 있다.
본 발명의 안티센스 올리고뉴클레오티드 등의 제제에는, 부형제, 결합제, 습윤제, 붕괴제, 활택제, 희석제, 교미제, 방향제, 용해보조제, 현탁화제, 유화제, 안정화제, 보존제, 장력제 등의 각종 의약용 첨가제를 필요에 따라 혼합할 수 있다.
본 발명의 안티센스 올리고뉴클레오티드 등의 의약조성물을 국소투여하는 경우, 예를 들면, 경피 패치, 연고, 로션, 크림, 겔, 적하제, 좌제, 분무제, 액제, 산제(散劑) 등의 제제를 사용할 수 있다.
본 발명의 안티센스 올리고뉴클레오티드 등의 의약조성물을 경구투여하는 경우, 예를 들면, 산제, 과립제, 물 또는 비수성(非水性) 매체에 용해시킨 현탁액 또는 용액, 캡슐, 분말제, 정제(錠劑) 등의 제제를 사용할 수 있다.
본 발명의 안티센스 올리고뉴클레오티드 등의 의약조성물을 비경구, 정맥내 투여, 피하투여, 또는 피내투여하는 경우, 예를 들면, 무균수용액 등의 제제를 사용할 수 있다.
본 발명의 단일가닥 안티센스 올리고뉴클레오티드의 유효투여량은, 투여되는 개체의 성별, 연령, 체중, 증상 등에 의해, 임의로 결정할 수 있다. 나아가허는, 투여의 방법, 경로, 빈도 등에 의해서도 임의로 결정할 수 있다. 예를 들면, 투여량으로서 0.01∼100mg/kg 등이다. 바람직하게는 0.1∼50mg/kg이며, 더욱 바람직하게는 0.1∼10mg/kg이다.
≪인간 WRN 유전자의 제27번째의 엑손을 고효율로 스킵핑하는 방법≫
본 실시형태에서의 인간 WRN 유전자의 제27번째의 엑손을 스킵핑하는 방법은, 상기 단일가닥 안티센스 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 상기 이중가닥 안티센스 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 또는 상기 안티센스 올리고뉴클레오티드 복합체 또는 그의 제약학적으로 허용되는 염을 유효성분으로서, 상기 WRN 유전자를 발현하고 있는 세포, 조직 또는 개체에 투여하는 공정을 포함한다.
본 실시형태에 있어서, 상기 단일가닥 안티센스 올리고뉴클레오티드 등을 세포, 조직 또는 개체에 투여하는 방법은, in vitro로 행해도 되고, in vivo로 행해도 된다. in vivo로 투여하는 경우, 그 투여 경로는, 전술한 투여 경로가 사용된다.
본 실시형태에 있어서, 「WRN 유전자를 발현하고 있는 세포」로서는, 섬유아세포, 지방세포, 간엽계 줄기세포, 케라티노사이트, 근육세포, 혈관내피세포, 평활근세포 등을 예로 들 수 있다.
본 실시형태에서의 베르너 증후군의 치료 방법 또는 예방 방법은, 상기 단일가닥 안티센스 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 상기 이중가닥 안티센스 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 또는 상기 안티센스 올리고뉴클레오티드 복합체 또는 그의 제약학적으로 허용되는 염을 유효성분으로서, 상기 베르너 증후군에 감염되어 있는 개체에 투여하는 공정을 포함한다.
이상, 본 실시형태에 따른안티센스 올리고뉴클레오티드에 대하여 설명했다. 전술한 구성을 구비하는 상기 단일가닥 안티센스 올리고뉴클레오티드는, 인간 WRN 유전자의 제27번째의 엑손을 고효율로 스킵핑하는 것이 가능하게 된다.
≪인간 WRN 유전자의 제27번째의 엑손을 스킵핑에 대한 활성의 평가 방법≫
<세포로의 안티센스 올리고뉴클레오티드의 도입>
「WRN 유전자를 발현하고 있는 세포」에 리포펙션법, 일렉트로포레이션법 또는 직접 첨가로 의한 도입 등의 방법을 사용하여 안티센스 올리고뉴클레오티드를 6시간∼1개월간 처치함으로써 관찰할 수 있다. 그리고 처치 시간은, 48시간∼7일간이 바람직하다. 사용하는 세포는 WRN 유전자가 발현하고 있는 세포이면 되고, 예를 들면, HEK293T 세포, 또는 베르너 증후군 환자 유래의 섬유아세포(이하, 「베르너 증후군 환자 섬유아세포」라고 함)가 있다. 안티센스 올리고뉴클레오티드를 처치한 세포는, 처치 후 즉시 회수해도 되고, 안티센스 올리고뉴클레오티드를 제거하여 계속 배양해도 된다.
<인간 WRN 유전자의 제27번째의 엑손 스킵핑 평가>
회수한 세포로부터 추출한 전체 RNA에 대하여 역전사반응을 실시하고, 얻어진 cDNA에 대하여 WRN 유전자의 엑손 27의 주변영역을 PCR로 증폭한다. 상기 PCR 증폭산물에 대하여, 폴리뉴클레오티드량의 정량(定量) 또는 시퀀스 해석을 행함으로써, WRN 유전자의 제27번째의 엑손 스킵핑을 확인할 수 있다. 스킵핑 효율은, 엑손 27이 스킵한 PCR산물의 폴리뉴클레오티드량 「A」 및 엑손 27이 스킵하지 않은 PCR산물의 폴리뉴클레오티드량 「B」를 정량하고, 이들 「A」와 「B」의 측정값을 하기 계산식에 따라, 스킵핑 효율(%)을 계산할 수 있다.
스킵핑 효율(%)=100×A/(A＋B)
그리고, 본 발명은, 전술한 실시형태로 한정되지 않는다. 예를 들면, 상기 단일가닥 안티센스 올리고뉴클레오티드는, 하기 실시 태양을 포함한다.
본 발명의 단일가닥 안티센스 올리고뉴클레오티드의 일태양으로서는,
인간 WRN 유전자의 제26번 또는 제28번 엑손의 스킵변이에 대하여, 기능적인 인간 WRN 단백질을 발현하는 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염으로서,
상기 올리고뉴클레오티드는, 각 뉴클레오티드가 인산기 및/또는 수식 인산기로 결합되어 있고,
상기 올리고뉴클레오티드는, 적어도 1개의 수식 당을 가지는 수식 핵산을 포함하고,
상기 올리고뉴클레오티드의 염기길이는, 10∼30mer이며,
상기 올리고뉴클레오티드의 염기서열은,
서열번호 1에 기재된 염기서열에서의, 상기 올리고뉴클레오티드와 동일한 염기길이로 구성된 적어도 1개의 표적 영역에 대하여 상보적인 염기서열을 기준으로 하여, 90% 이상 100% 이하의 서열동일성을 가지는 염기서열,
상기 표적 영역에 있어서 1개 또는 수개의 염기가 결실, 치환, 삽입 또는 부가 된 염기서열에 대하여, 상보적인 염기서열, 또는,
상기 표적 영역을 가지는 올리고뉴클레오티드에 대하여, 스트린젠트한 조건 에서 하이브리다이징하는 염기서열인, 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염이다.
본 발명의 단일가닥 안티센스 올리고뉴클레오티드의 다른 일태양으로서는, 상기 단일가닥 안티센스 올리고뉴클레오티드의 염기서열은,
서열번호 1, 서열번호 2, 서열번호 3, 서열번호 4, 서열번호 5, 또는 서열번호 6에 기재된 염기서열에서의, 상기 단일가닥 안티센스 올리고뉴클레오티드와 동일한 염기길이로 구성된 적어도 1개의 표적 영역에 대하여 상보적인 염기서열을 기준으로 하여, 95% 이상 100% 이하의 서열동일성을 가지는 염기서열이다.
본 발명의 단일가닥 안티센스 올리고뉴클레오티드의 다른 일태양으로서는, 상기 단일가닥 안티센스 올리고뉴클레오티드의 염기서열은, 서열번호 1, 서열번호 2, 서열번호 3, 서열번호 4, 서열번호 5, 또는 서열번호 6에 기재된 염기서열에서의, 상기 단일가닥 안티센스 올리고뉴클레오티드와 동일한 염기길이로 구성된 적어도 1개의 표적 영역에 대하여 상보적인 염기서열이다.
본 발명의 단일가닥 안티센스 올리고뉴클레오티드의 다른 일태양으로서는,
상기 올리고뉴클레오티드를 구성하는 당이 D-리보퓨라노스이며, 당의 수식이 D-리보퓨라노스의 2'위치의 수산기의 당수식이다.
상기 올리고뉴클레오티드의 염기길이는, 15∼25mer이다.
본 발명의 단일가닥 안티센스 올리고뉴클레오티드의 다른 일태양으로서는,
상기 올리고뉴클레오티드를 구성하는 당의 수식이 하기 식(A1)으로 표시되는 기이다.
(식 중, Bx는 핵산염기이며, 각각, 독립적으로, 아데닌, 구아닌, 시토신, 5-메틸시토신, 티민 또는 우라실로 표시되는 기이며, X는 인산 결합이며, 각각, 독립적으로, 포스포디에스테르 결합, 포스포로티오에이트 결합, 포스포로디티오에이트 결합, 포스포아미데이트 결합, 보라노포스페이트 결합 또는 알킬포스포네이트 결합이며, Y는, 각각, 독립적으로, 수소 원자, 수산기, 불소 원자, 치환되어 있어도 되는 탄소수 1∼6의 알콕시기, 또는 치환되어 있어도 되는 아미노기이며, Z는, 각각, 독립적으로, 수소 원자인가, 탄소-산소 이중결합 또는 환상 구조를 가지고 있어도 되는 탄소수 1∼5의 알킬기이거나, 또는 상기 알킬기의 일부 탄소 원자와 Y가 합쳐져서 환을 형성함). 상기 탄소수 1∼5의 알킬기가 가지는 「탄소-산소 이중결합」으로서는, 예를 들면, 카르보닐기가 있다. 상기 탄소수 1∼5의 알킬기가 가지는 「환상 구조」로서는, 예를 들면 시클로프로판 구조가 있다.
본 발명의 단일가닥 안티센스 올리고뉴클레오티드의 다른 일태양으로서는,
상기 올리고뉴클레오티드 중 적어도 1개의 뉴클레오티드간 결합이 포스포로티오에이트 결합이다.
본 발명의 단일가닥 안티센스 올리고뉴클레오티드의 다른 일태양으로서는,
상기 올리고뉴클레오티드 중 적어도 1개의 뉴클레오티드간 결합이 포스포디에스테르 결합이다.
본 발명의 단일가닥 안티센스 올리고뉴클레오티드의 다른 일태양으로서는,
상기 올리고뉴클레오티드의 염기서열은,
서열번호 1에 기재된 염기서열에 있어서, 5'말단으로부터 카운트하여 1번∼12번, 14번∼21번, 24번, 25번, 29번∼31번, 34번, 36번, 41번, 46번, 51번, 혹은 62번에 위치하는 염기로부터 연속된 15∼25mer로 구성된 표적 영역에 대하여 상보적인 염기서열을 기준으로 하여, 90% 이상 100% 이하의 서열동일성을 가지는 염기서열,
상기 표적 영역에 있어서, 1개 또는 수개의 염기가 결실, 치환, 삽입 또는 부가 된 염기서열에 대하여 상보적인 염기서열, 또는,
상기 표적 영역을 가지는 올리고뉴클레오티드에 대하여, 스트린젠트한 조건에서 하이브리다이징하는 염기서열이다.
본 발명의 단일가닥 안티센스 올리고뉴클레오티드의 다른 일태양으로서는,
상기 올리고뉴클레오티드의 염기서열은,
서열번호 1에 기재된 염기서열에 있어서, 5'말단으로부터 카운트하여 1번∼40번, 46번, 51번, 56번, 또는 62번∼63번에 위치하는 염기로부터 연속된 15∼25mer로 구성된 표적 영역, 또는 서열번호 2에 기재된 염기서열에 있어서, 5'말단으로부터 카운트하여 108873번, 108878번∼108917번, 108923번, 108928번, 108933번, 또는 108939번∼108940번에 위치하는 염기로부터 연속된 15∼25mer로 구성된 표적 영역에 대하여 상보적인 염기서열을 기준으로 하여, 90% 이상 100% 이하의 서열동일성을 가지는 염기서열,
상기 표적 영역에 있어서, 1개 또는 수개의 염기가 결실, 치환, 삽입 또는 부가 된 염기서열에 대하여 상보적인 염기서열, 또는,
상기 표적 영역을 가지는 올리고뉴클레오티드에 대하여, 스트린젠트한 조건에서 하이브리다이징하는 염기서열이다.
본 발명의 단일가닥 안티센스 올리고뉴클레오티드의 다른 일태양으로서는,
상기 올리고뉴클레오티드의 염기서열은, 서열번호 1에 기재된 염기서열에 있어서, 5'말단으로부터 카운트하여 1번, 3번∼12번, 14번∼19번, 21번, 25번, 29번, 30번, 31번, 34번, 46번, 혹은 51번에 위치하는 염기로부터 연속된 15∼25mer로 구성된 표적 영역에 대하여 상보적인 염기서열을 기준으로 하여, 90% 이상 100% 이하의 서열동일성을 가지는 염기서열이다.
본 발명의 단일가닥 안티센스 올리고뉴클레오티드의 다른 일태양으로서는,
상기 올리고뉴클레오티드의 염기서열은, 서열번호 1에 기재된 염기서열에 있어서, 5'말단으로부터 카운트하여 1번∼32번, 34번∼40번, 46번, 51번, 또는 62번∼63번에 위치하는 염기로부터 연속된 15∼25mer로 구성된 표적 영역, 또는 서열번호 2에 기재된 염기서열에 있어서, 5'말단으로부터 카운트하여 108878번∼108909번, 108911번∼108917번, 108923번, 108928번, 또는 108939번∼108940번에 위치하는 염기로부터 연속된 15∼25mer로 구성된 표적 영역에 대하여 상보적인 염기서열을 기준으로 하여, 90% 이상 100% 이하의 서열동일성을 가지는 염기서열이다.
본 발명의 단일가닥 안티센스 올리고뉴클레오티드의 다른 일태양으로서는,
상기 올리고뉴클레오티드의 염기서열은, 서열번호 1에 기재된 염기서열에 있어서, 5'말단으로부터 카운트하여 1번, 3번, 6번∼12번, 14번∼19번, 21번, 25번, 29번, 30번, 31번, 34번, 46번, 혹은 51번에 위치하는 염기로부터 연속된 15∼25mer로 구성된 표적 영역에 대하여 상보적인 염기서열을 기준으로 하여, 90% 이상 100% 이하의 서열동일성을 가지는 염기서열이다.
본 발명의 단일가닥 안티센스 올리고뉴클레오티드의 다른 일태양으로서는,
상기 올리고뉴클레오티드의 염기서열은, 서열번호 1에 기재된 염기서열에 있어서, 5'말단으로부터 카운트하여 1번, 3번, 5번∼12번, 14번∼19번, 21번, 25번, 29번, 30번, 31번, 34번, 46번, 또는 51번에 위치하는 염기로부터 연속된 15∼25mer로 구성된 표적 영역, 또는 서열번호 2에 기재된 염기서열에 있어서, 5'말단으로부터 카운트하여 108878번, 108880번, 108882번∼108889번, 108891번∼108896번, 108898번, 108902번, 108906번∼108908번, 108911번, 108923번, 또는 108928번에 위치하는 염기로부터 연속된 15∼25mer로 구성된 표적 영역에 대하여 상보적인 염기서열을 기준으로 하여, 90% 이상 100% 이하의 서열동일성을 가지는 염기서열이다.
본 발명의 단일가닥 안티센스 올리고뉴클레오티드의 다른 일태양으로서는,
상기 올리고뉴클레오티드를 구성하는 당의 수식이 하기 식(A2) 또는 식(A3)으로 표시되는 기이다.
(식 중, Bx는 핵산염기이며, 각각, 독립적으로, 아데닌, 구아닌, 시토신, 5-메틸시토신, 티민 또는 우라실로 표시되는 기이며, X는 인산 결합이며, 각각, 독립적으로, 포스포디에스테르 결합, 포스포로티오에이트 결합, 포스포로디티오에이트 결합, 포스포아미데이트 결합, 보라노포스페이트 결합 또는 알킬포스포네이트 결합이며, R4는, 각각, 독립적으로, 수소 원자, 치환되어 있어도 되는 탄소수 1∼6의 알킬기이며, Y'는, 산소 원자 또는 치환되어 있어도 되는 질소 원자이며, R5 및 R6는, 각각, 독립적으로, 수소 원자, 치환되어 있어도 되는 탄소수 1∼6의 알킬기, 또는 R5 및 R6가 합쳐져서 카르보닐기 또는 환을 형성하고 있고, n은, 0∼1이다.)
본 발명의 단일가닥 안티센스 올리고뉴클레오티드의 다른 일태양으로서는,
상기 올리고뉴클레오티드의 염기서열은, 서열번호 9, 11, 14∼22, 24∼29, 31, 35, 39∼41, 44, 52, 및 53의 염기서열로 이루어지는 군으로부터 선택되는 1개의 염기서열이다.
본 발명의 단일가닥 안티센스 올리고뉴클레오티드의 다른 일태양으로서는,
상기 올리고뉴클레오티드의 염기서열은, 서열번호 9∼14, 16∼26, 28∼39, 41∼42, 44∼50, 52, 55∼56, 69, 73, 80∼105, 107∼108, 110, 112, 114, 116, 118∼131, 133, 및 135의 염기서열로 이루어지는 군으로부터 선택되는 1개의 염기서열이다.
본 발명의 단일가닥 안티센스 올리고뉴클레오티드의 다른 일태양으로서는,
상기 올리고뉴클레오티드의 염기서열은, 단일가닥 안티센스 올리고뉴클레오티드이다.
실시예
이하, 본 발명에 따른 실시예를 설명하지만, 본 발명은 이들로 한정되는 것은 아니다.
≪WRN 유전자에 대한 단일가닥 안티센스 올리고뉴클레오티드의 제작≫
하기 수순으로 WRN 유전자에 대한 단일가닥 안티센스 올리고뉴클레오티드를 제작했다.
2'-OMe(O-메틸), 2'-MOE(O-메톡시에틸), AmNA, scpBNA, 및 GuNA를 포함하는 단일가닥 안티센스 올리고뉴클레오티드는, 핵산자동합성기(nS-8형, 가부시키가이샤 진디자인 제조)를 사용하여, 0.2㎛ol 스케일로 합성했다. 쇄길이의 신장(伸長)은, 표준적인 포스포로아미다이트 프로토콜에 의해 실시했다. 이 때 고상담체는, CPG 레진을 사용했다. 또한, 포스포로티오에이트화(PS) 골격 형성을 위한 황화는 DDTT(((Dimethylamino-methylidene)amino)-3H-1,2,4-dithiazaoline-3-thione) 등을 사용했다. AmNA 및 scpBNA를 포함하는 안티센스 올리고뉴클레오티드는, 말단의 5'위의 수산기가 DMTR(4,4'-디메톡시트리틸)기로 보호되고 있지 않고, 또한 3'위치가 고상에 담지된 것으로서 얻었다. 계속해서 알칼리 처리함으로써, 상기 단일가닥 안티센스 올리고뉴클레오티드를 고상담체로부터 잘라내고, 용액의 상태로 회수했다. 그 후, 회수한 용액으로 용매를 증류제거함으로써 조생성물을 얻었다. 얻어진 조생성물을 역상HPLC로 정제함으로써 정제된 단일가닥 안티센스 올리고뉴클레오티드를 얻었다. 얻어진 각각의 단일가닥 안티센스 올리고뉴클레오티드의 순도 및 구조를 LC-MS(WateRs사 제조)에 의해 확인했다. 모르폴리노핵산을 포함하는 모르폴리노올리고핵산은, 국제공개 제2009/064471호(특허문헌 5) 또는, J.Am.Chem.Soc(2016) 138: 15663-15672(비특허문헌 8)에 따라 합성했다.
하기 표 2-1∼표 2-7에, 전술한 방법으로 제조한 단일가닥 안티센스 올리고뉴클레오티드를 열거한다.
[표 2-1]
[표 2-2]
[표 2-3]
[표 2-4]
[표 2-5]
[표 2-6]
[표 2-7]
본 명세서에 있어서, 하기 기호 또는 표기를 사용하여, 대응하는 구조를 표시하는 경우가 있다.
위에서 나타내는 구조식에 있어서, R1, R2, 및 R3는, 각각 독립적으로, 수소 원자, 또는, 직쇄 또는 분지의 탄소수 1∼6의 알킬기, 또는 탄소수 3∼7의 시클로알킬기를 나타낸다. 여기에서, 전술한 「Gx」로 나타내는 GuNA에서의 R1 및 R3가 모두 수소 원자이며, 또한, R2가 메틸기인 경우에는, 「Gm」으로 나타내고, R1이 수소 원자이며, 또한, R2 및 R3가 모두 메틸기인 경우에는, 「Gdm」으로 나타내고, R1 및 R3가 수소 원자이며, 또한, R2가 tert-부틸기인 경우에는, 「GtB」로 나타낸다.
≪인간 WRN 유전자의 제27번째의 엑손 스킵핑 평가≫
인간 WRN 유전자의 제27번째의 엑손 스킵핑 평가는, HEK293T세포나 엑손 26을 결실한 베르너 증후군 환자 섬유아세포에서의 엑손 27 스킵핑의 유도를 확인함으로써 행하였다.
본 실시예에서의 유전자발현평가는, 역전사반응에 의해 얻어진 상보적 DNA(cDNA)에 대하여 WRN 유전자의 엑손 26(정상 WRN 유전자를 가지는 HEK293T) 혹 25(엑손 26을 결실한 베르너 증후군 환자 섬유아세포)로부터 29에 걸친 영역을, PCR법을 사용하여 증폭한 양을 측정함으로써 WRN 유전자의 제27번째의 엑손의 서열 구조를 평가하는 것을 의미한다. 이하, 각 발현평가의 구체적 수순에 대하여 설명한다.
(세포로의 안티센스 올리고뉴클레오티드의 도입)
「인간 WRN 유전자를 발현하고 있는 세포」에 리포펙션법 혹은 직접첨가에 의한 도입등의 방법을 사용하여 안티센스 올리고뉴클레오티드를 2일간 처치했다. 사용하는 세포는 WRN 유전자가 발현하고 있는 세포(예를 들면, HEK293T세포 또는 엑손 26을 결실한 베르너 증후군 환자 섬유아세포)를 사용했다. 안티센스 올리고뉴클레오티드를 처치한 세포는, 처치 후 즉시 회수하거나, 또는, 안티센스 올리고뉴클레오티드를 제거하여 계속 배양하고나서 회수했다.
(WRN cDNA의 해석)
회수한 세포로부터 추출한 전체 RNA에 대하여 역전사반응을 실시하고, 얻어진 cDNA에 대하여 WRN 유전자의 엑손 26∼엑손 29에 걸친 영역(정상 WRN 유전자를 가지는 HEK293T세포를 사용한 경우), 혹은 WRN 유전자의 엑손 25∼엑손 29에 걸친 영역(엑손 26을 결실한 베르너 증후군 환자 섬유아세포를 사용한 경우)을, PCR법을 사용하여 증폭했다. 이러한 증폭 시에는, 어닐링 온도 60℃를 설정했다.
(엑손 27의 스킵핑의 확인)
이와 같이 하여, 정상 WRN 유전자를 가지는 HEK293T에 있어서, WRN cDNA의 엑손 26∼29의 영역을 증폭한 바, 안티센스 올리고뉴클레오티드의 무첨가에서는 290 염기쌍의 밴드가 얻어졌다. 이 증폭산물의 염기서열을 통상적인 방법에 의해 결정한 바, 이것이 엑손 26, 엑손 27, 엑손 28, 엑손 29로 이루어지는 것으로 나타났다.
마찬가지로, 엑손 26을 결실한 베르너 증후군 환자 섬유아세포에 있어서는, WRN cDNA의 엑손 25∼엑손 29의 영역을 증폭한 바, 안티센스 올리고뉴클레오티드의 무첨가에서는 290 염기쌍의 밴드가 얻어졌다. 이 증폭산물의 염기서열을 통상적인 방법에 의해 결정한 바, 이것이 엑손 25, 엑손 27, 엑손 28, 엑손 29로 이루어지는 것으로 나타났다. 이 결과는 환자의 유전자해석 결과와 양호하게 일치하였다.
한편, 안티센스 올리고뉴클레오티드를 도입한 HEK293T세포의 cDNA에서는, 안티센스 올리고뉴클레오티드를 도입하지 않는 세포로부터 얻어진 증폭산물과 동일한 사이즈의 증폭산물이 얻어졌을 뿐만 아니라, 배양 48시간 후, 작은 사이즈의 증폭산물이 얻어졌다. 이 증폭산물의 염기서열을 통상적인 방법에 의해 결정한 바, 이것이 엑손 26, 엑손 28, 엑손 29로 이루어지는 것으로 나타났다. 이 조건에서 작은 사이즈의 전사물, 즉 엑손 27의 스킵핑을 가지는 것만이 얻어졌다.
안티센스 올리고뉴클레오티드를 도입한 전술한 베르너 증후군 환자 섬유아세포의 cDNA에서는, 안티센스 올리고뉴클레오티드를 도입하지 않는 세포로부터 얻어진 증폭산물보다 작은 사이즈의 증폭산물이 얻어졌다. 이 작은 사이즈의 증폭산물의 염기서열을 결정한 바, 엑손 25의 서열이 직접 엑손 28의 서열에 연결되어 있고, 엑손 26과 엑손 27의 결실이 판명되었다. 이는, 안티센스 올리고뉴클레오티드처리에 의해 엑손 27이 스킵핑한 것을 나타내고 있다.
정상인 인간 WRN 유전자구조를 가지는 유전자로부터 전사된 mRNA 전구체도 스플라이싱 반응에 있어서, 본 발명자들은 디자인한 안티센스 올리고뉴클레오티드가 엑손 27의 스킵핑을 효과적으로 유도하는 것을 확인했다. 또한, 제26번 엑손의 스킵변이 c.3139-1G>C를 가지는 베르너 증후군 환자 섬유아세포(엑손 26을 결실한 베르너 증후군 환자 섬유아세포)에서도, 본 발명자들은 디자인한 안티센스 올리고뉴클레오티드가 엑손 27의 스킵핑을 효과적으로 유도하는 것을 확인했다. 이하, 각종 시험에 기초하여 본 발명을 더욱 상세하게 설명한다.
≪WRN 유전자의 엑손 27 스킵핑의 유도 평가≫
WRN 유전자의 엑손 27 스킵핑의 유도 평가는, 제조한 단일가닥 안티센스 올리고뉴클레오티드에 따라, 인간태아신장세포 HEK293T세포를 사용한 평가와, 26번 엑손의 스킵변이 c.3139-1G>C를 가지는 베르너 증후군 환자 섬유아세포를 사용한 평가로 나누어서 행하였다. 이하, 구체적 수순에 대하여 설명한다.
<인간태아신장세포 HEK293T세포를 사용한 엑손 27 스킵핑의 유도 평가>
인간태아신장세포 HEK293T세포(ATCC(등록상표) CRL-3216(상표))를, 배양 배지 중, 37℃, 5% CO2의 조건에서 배양했다. HEK293T세포의 배양 배지로서는, 하기 조성의 것을 사용했다.
HEK293T세포의 배양 배지 조성
둘베코수정이글배지(DMEM): Thermo Fisher Scientific사 제조, Cat#11995
10% 우태아혈청(FBS): Thermo Fisher Scientific사 제조, Cat#10437028
먼저, 트랜스펙션의 전날에, 96웰플레이트에 HEK293T세포(12000cells/well)를 파종하고, 37℃, 5% CO2의 조건에서 하룻밤 배양했다. 그 후, 인산완충생리식염수(PBS)로 희석한 각각의 단일가닥 안티센스 올리고뉴클레오티드(50nM)를 리포펙션법에 의해, 전술한 세포에 트랜스펙션했다. 음성대조군으로서는, 단일가닥 안티센스 올리고뉴클레오티드가 용해하고 있지 않은 PBS를 트랜스펙션한 세포를 사용했다. 트랜스펙션한 세포를 배양 배지 중에서 37℃, 5% CO2의 조건에서 48시간 배양했다. 그 후, 상기 배양 배지를 제거하고, Taqman Fast Cells-to-CT Kit(Thermo Fisher Scientific사 제조, Cat#4399003)을 사용하여, 추출한 전체 RNA에 대하여 역전사반응을 실시했다. 이 역전사반응으로부터 얻어진 상보적 DNA(cDNA)를 사용하여, 미리 설계된 특이적 프라이머(하기 참조)를 사용하여 WRN 유전자의 엑손 25∼엑손 29에 걸친 PCR을 실시했다.
사용한 PCR의 프로그램은, 하기와 같다.
94℃, 1분간: 열변성
[98℃, 10초간; 60℃, 5초간; 68℃, 40초간] ×35사이클: PCR 증폭
유전자 특이적 프라이머는 WRN_Exon26_Fw 및 WRN_Exon29_Rv를 사용했다.
WRN_Exon26_Fw: 5'-CTCAGAGCCTCATCCTTCAAGCTAATG-3'
WRN_Exon29_Rv: 5'-CAATCTGAGTCTCCTGCTCTTGTGC-3'
상기 PCR 반응의 반응물을 3% 아가로스겔전기영동에 의해 분리하고, LED트랜스일루미네이터겔미에루(Wako사)와 iPhone8(Apple사)를 조합한 촬영 시스템에 의해, 겔 사진을 촬영했다.
전술한 방법으로 구해진, 인간 WRN mRNA 전구체에 대한 각각의 단일가닥 안티센스 올리고뉴클레오티드(도 4)에 의한 인간 WRN 유전자의 엑손 27의 스킵핑 활성 측정의 실험 결과를 도 5에 나타낸다.
정상 WRN 유전자를 가지는 HEK293T세포에 있어서, WRNcDNA의 엑손 26∼엑손 29의 영역을 증폭한 바, 안티센스 올리고뉴클레오티드를 도입하지 않은 샘플(도 5중, 「무첨가」로 표기)에서는 291 염기쌍의 밴드가 얻어졌다. 이 증폭산물의 염기서열을 DNA시퀀싱에 의해 결정한 바, 이 밴드가 엑손 26, 엑손 27, 엑손 28, 엑손 29로 이루어지는 것으로 나타났다.
한편, 각각의 안티센스 올리고뉴클레오티드를 첨가한 HEK293T세포의 cDNA에서는, 안티센스 올리고뉴클레오티드를 도입하지 않는 세포로부터 얻어진 증폭산물과 동일한 사이즈의 증폭산물이 얻어졌을 뿐만 아니라, 배양 48시간 후, 작은 사이즈의 증폭산물(215염기쌍)이 얻어졌다. 이 증폭산물의 염기서열을 시퀀싱에 의해 결정한 바, 상기 증폭산물은 엑손 26, 엑손 28, 엑손 29로 이루어지는 것으로 나타났다. 또한 이 조건으로 작은 사이즈의 증폭산물만이 인정되는, 즉 고효율의 엑손 27의 스킵핑 활성을 가지는 안티센스 올리고뉴클레오티드도 얻어졌다.
ImageJ(미국 NIH)에 의해, 엑손 27이 스킵한 PCR산물 「215bp, A」와, 및 엑손 27이 스킵하지 않은 PCR산물 「291bp, B」를 정량했다. 이들 「A」와 「B」의 측정값을 하기 계산식에 따라, 하기 식을 사용하여 스킵핑 효율(%)을 구했다. 그 결과를 표 3-1∼표 3-3에 나타내었다.
스킵핑 효율(%)=100×A/(A＋B)
[표 3-1]
[표 3-2]
[표 3-3]
<베르너 증후군 환자 섬유아세포의 WRN 유전자변이형의 확인>
베르너 증후군 환자 섬유아세포(CoRiell Cell Repositories, Cat#AG12795)를, 배양 배지 중, 37℃, 5% CO2의 조건에서 배양했다. 베르너 증후군 환자 섬유아세포의 배양 배지로서는, 하기 조성의 것을 사용했다.
베르너 증후군 환자 섬유아세포의 배양 배지 조성
이글최소필수배지(MEM): Sigma사 제조, Cat#M5650
15% FBS: Thermo Fisher Scientific사 제조, Cat#10437028
상기한 베르너 증후군 환자 섬유아세포에서의 WRN 유전자변이형에 대하여 유전자변이의 해석을 행하였다. 96웰플레이트에 베르너 증후군 환자 섬유아세포(10000cells/well)를 파종하고, 37℃, 5% CO2의 조건에서 하룻밤 배양했다. 그 후, 세포의 게놈 DNA를 추출하고, 미리 설계된 특이적 프라이머(하기 참조)를 사용하여 WRN 유전자의 엑손 25∼엑손 29에 걸친 PCR을 실시했다.
사용한 PCR의 프로그램은, 하기와 같다.
94℃, 1분간: 열변성
[98℃, 10초간; 60℃, 5초간; 68℃, 40초간] ×35사이클: PCR 증폭
유전자 특이적 프라이머는 WRN_Exon25_Fw 및 WRN_Exon29_Rv를 사용했다.
WRN_Exon25_Fw: 5'-CTGGCAAGGATCAAACAGAGAGTTG-3'
WRN_Exon29_Rv: 5'-CAATCTGAGTCTCCTGCTCTTGTGC-3'
상기 PCR 반응의 반응물을 3% 아가로스겔 전기영동으로서 분리하고, LED 트랜스일루미네이터겔미에루(Wako사)에 의해, 증폭한 PCR단편을 검출하고, PCR단편을 포함하는 겔을 잘라내었다. 증폭한 PCR단편을 정제하고 시퀀싱에 의한 해석을 실시한 바, 상기 베르너 증후군 환자 섬유아세포는 WRN 유전자의 c. 3139-1G>C의 호모 접합체인 것이 확인되었다.
<베르너 증후군 환자 섬유아세포를 사용한 엑손 27 스킵핑의 유도 평가>
다음으로, WRN 유전자의 c. 3139-1G>C의 호모 접합체인 베르너 증후군 환자 섬유아세포를 사용하여, WRN 유전자의 엑손 27 스킵핑의 유도 평가를 행하였다. 트랜스펙션의 전날에, 96웰플레이트에 베르너 증후군 환자 섬유아세포(10000cells/well)를 파종하고, 37℃, 5% CO2의 조건에서 하룻밤 배양했다.
그 후, 리포펙션법에 의한 도입방법을 사용하여 안티센스 올리고뉴클레오티드를 48시간∼10일간 처치했다. PBS로 희석한 각각의 단일가닥 안티센스 올리고뉴클레오티드(최종농도 1∼50nM)를 리포펙션법으로, 전술한 세포에 트랜스펙션했다. 음성대조군으로서는, 단일가닥 안티센스 올리고뉴클레오티드가 용해하고 있지 않은PBS를 트랜스펙션한 세포를 사용했다. 안티센스 올리고뉴클레오티드로 처치한 세포를 배양 배지 중에서 37℃, 5% CO2의 조건에서 48시간 또는 240시간 배양했다. 그 후, 상기 배양 배지를 제거하고, Taqman Fast Cells-to-CT Kit(Thermo Fisher Scientific사 제조, Cat#4399003)을 사용하여, 추출한 전체 RNA에 대하여 역전사반응을 실시했다. 이 역전사반응으로부터 얻어진 상보적 DNA(cDNA)를 사용하여, 미리 설계된 특이적 프라이머(하기 참조)를 사용하여 WRN 유전자의 엑손 25∼엑손 29에 걸친 PCR을 실시했다. 사용한 PCR의 프로그램은, 하기와 같다.
94℃, 1분간: 열변성
[98℃, 10초간; 60℃, 5초간; 68℃, 40초간] ×35사이클: PCR 증폭
유전자 특이적 프라이머는 WRN_Exon25_Fw 및 WRN_Exon29_Rv를 사용했다.
WRN_Exon25_Fw: 5'-CTGGCAAGGATCAAACAGAGAGTTG-3'
WRN_Exon29_Rv: 5'-CAATCTGAGTCTCCTGCTCTTGTGC-3'
상기 PCR 반응의 반응물을 3% 아가로스겔 전기영동으로서 분리하고, LED 트랜스일루미네이터겔미에루(Wako사)와 iPhone8(Apple사)을 조합한 촬영 시스템에 의해, 겔 사진을 촬영했다.
전술한 방법으로 구해진, 인간 WRN mRNA 전구체에 대한 각각의 단일가닥 안티센스 올리고뉴클레오티드에 의한 인간 WRN 유전자의 엑손 27의 스킵핑 활성측정의 실험 결과를 도 6에 나타내었다. 베르너 증후군 환자 섬유아세포에 있어서는, WRNcDNA의 엑손 25∼엑손 29의 영역을 증폭한 바, 안티센스 올리고뉴클레오티드를 도입하지 않은 샘플(도 6 중, 「무첨가」로 표기)에서는 352 염기쌍의 밴드가 얻어졌다. 이 증폭산물의 염기서열을 시퀀싱에 의해 결정한 바, 이 밴드가 엑손 25, 엑손 27, 엑손 28, 엑손 29로 이루어지는 것으로 나타났다. 이 결과는 환자의 유전자해석 결과와 양호하게 일치한다.
한편,안티센스 올리고뉴클레오티드를 첨가한 베르너 증후군 환자 섬유아세포의 cDNA에서는, 안티센스 올리고뉴클레오티드를 도입하지 않는 세포로부터 얻어진 산물보다 작은 사이즈의 산물(276 염기쌍)이 얻어졌다. 이 작은 사이즈의 증폭산물의 염기서열을 시퀀싱에 의해 결정한 바, 엑손 25의 서열이 직접 엑손 28의 서열에 연결되어 있고, 엑손 26과 엑손 27의 결실이 판명되었다. 이는, 안티센스 올리고뉴클레오티드처리에 의해 엑손 27이 스킵핑한 것을 나타내고 있다.
ImageJ(미국 NIH)에 의해, 엑손 27이 스킵한 PCR산물 「276bp, A」와, 및 엑손 27이 스킵하지 않은 PCR산물 「352bp, B」를 정량했다. 이들 「A」와 「B」의 측정값을 하기 계산식에 따라, 하기 식을 사용하여 스킵핑 효율(%)을 구했다. 그 결과를 표 4-1A∼4-1F, 표 4-2A∼4-2D, 표 4-3A∼4-3D, 표 4-4A∼4-4D 및 표 4-5에 나타내었다.
스킵핑 효율(%)=100×A/ (A＋B)
[표 4-1A]
[표 4-1B]
[표 4-1C]
[표 4-1D]
[표 4-1E]
[표 4-1F]
[표 4-2A]
[표 4-2B]
[표 4-2C]
[표 4-2D]
[표 4-3A]
[표 4-3B]
[표 4-3C]
[표 4-3D]
[표 4-4A]
[표 4-4B]
[표 4-4C]
[표 4-4D]
[표 4-5]
<베르너 증후군 환자 섬유아세포에서의 안티센스 올리고뉴클레오티드에 의한 기능적인 WRN 단백질 발현의 유도>
WRN 유전자의 c. 3139-1G>C의 호모 접합체인 베르너 증후군 환자 섬유아세포를 사용하여, WRN 유전자의 엑손 27 스킵핑에 의한 기능적인 WRN 단백질 발현의 유도 평가를 행하였다. 평가 전날에, 96웰플레이트에 베르너 증후군 환자 섬유아세포(10000cells/well)를 파종하고, 37℃, 5% CO2의 조건에서 하룻밤 배양했다. 그 후, PBS로 희석한 서열번호 28의 염기서열로 이루어지는 단일가닥 안티센스 올리고뉴클레오티드(최종농도 50nM)를 리포펙션법으로, 전술한 세포에 트랜스펙션했다. 음성대조군으로서는, 단일가닥 안티센스 올리고뉴클레오티드가 용해하고 있지 않은PBS를 트랜스펙션한 세포를 사용했다. 트랜스펙션한 세포를 배양 배지 중에서 37℃, 5% CO2의 조건에서 48시간 배양했다. 그 후, 세포를 4% paraformaldehyde(후지필름와코순약사 제조, Cat#163-20145)로 15분간으로 고정하고, 0.5% Triton-X(나카라이테스크사 제조, Cat#12967-45)로 10분간 인큐베이팅했다. 계속해서, 인큐베이팅한 상기 세포를 5% 염소 혈청을 함유하는 PBS로 1시간 블록킹하고, 항WRN항체(Cell Signaling사 제조, Cat#4666) 용액 중에서 하룻밤 인큐베이팅했다. 또한 항마우스IgG항체(Thermo Fisher Scientific사 제조, A32766) 용액 중에서, 상기 세포를 1시간 인큐베이팅했다. 마지막으로 Hoechst(등록상표) 33342핵산염색(Thermo Fisher Scientific사 제조, Cat#H3570) 용액 중에서 15분간 인큐베이팅하고, 형광현미경으로 관찰했다.
전술한 방법으로 구해진, 인간 WRN mRNA 전구체에 대한 단일가닥 안티센스 올리고뉴클레오티드에 의한 WRN 유전자의 엑손 27의 스킵핑 활성에 의한 기능적인 WRN 단백질 발현의 유도 결과를 도 7에 나타내었다. 도 7로부터, 서열번호 28의 염기서열로 이루어지는 단일가닥 안티센스 올리고뉴클레오티드를 트랜스펙션한 세포(도 7에서의 「ASO: No.28」)에서는 상기 기능적인 WRN 단백질이 핵내 이행하고 있는 것을 알 수 있다.
<베르너 증후군 환자 섬유아세포에서의 안티센스 올리고뉴클레오티드에 의한 세포증식의 촉진>
인간 WRN 유전자의 c. 3139-1G>C의 호모 접합체인 베르너 증후군 환자 섬유아세포를 사용하여, WRN 유전자의 엑손 27 스킵핑에 의한 세포증식능의 평가를 행하였다. 평가 전날에, 96웰플레이트에 베르너 증후군 환자 섬유아세포(12000 cells/well)를 파종하고, 37℃, 5% CO2의 조건에서 하룻밤 배양했다. 그 후, PBS로 희석한 각각의 단일가닥 안티센스 올리고뉴클레오티드(최종농도 10nM)를 리포펙션법으로, 전술한 세포에 트랜스펙션했다. 음성대조군으로서는, 단일가닥 안티센스 올리고뉴클레오티드가 용해하고 있지 않은 PBS를 트랜스펙션한 세포를 사용했다. 트랜스펙션한 세포를 배양 배지 중에서 37℃, 5% CO2의 조건에서 288시간 배양했다. 그 후, 상기 증식 배지에 Celltiter-Glo 2.0 Assay(Promega사 제조, Cat#G9242)을 첨가하여 세포수를 측정했다. 단일가닥 안티센스 올리고뉴클레오티드를 트랜스펙션한 세포의 세포수 「A」와 음성대조군의 세포수 「B」의 측정값을 하기 계산식에 따라, 하기 식을 사용하여 세포증식율(%)을 구했다. 그 결과를 표 5에 나타낸다.
세포증식율(%)=100×(A)/B
[표 5]
≪단일가닥 안티센스 올리고뉴클레오티드의 세포독성평가≫
인간간암 유래 세포주인 HepG2세포를, 증식 배지 중, 37℃, 5% CO2 조건에서 배양했다. 증식 배지로서는, 하기 조성의 것을 사용했다.
세포독성평가에 사용한 증식 배지의 조성
10% FBS: GIBCO사 제조, CAT#10270-106
Minimum Essential Medium(L-글루타민, 페놀레드 함유)(GIBCO사 제조, CAT#11095-080)
실험 전날에 96웰플레이트에 상기 세포(1.5×104cells/well)를 파종했다. 파종한 세포를 37℃, 5% CO2의 조건에서 하룻밤 배양 한 후, 그 후, PBS로 희석한 각각의 단일가닥 안티센스 올리고뉴클레오티드(최종농도 3∼30nM)를 리포펙션법으로, 전술한 세포에 트랜스펙션했다. 첨가 후, 37℃, 5% CO2의 조건에서 24시간 상기 세포를 배양했다. 음성대조군으로서는, 단일가닥 안티센스 올리고뉴클레오티드가 용해하고 있지 않은 PBS를 트랜스펙션한 세포를 사용했다. 그 후, 상기 증식 배지에, Caspase-Glo 3/7 Assay System(Promega사 제조, Cat#G8093)을 첨가하여 카스파제 활성을 평가했다. 전술한 방법으로 구해진, 각각의 단일가닥 안티센스 올리고뉴클레오티드에서의 카스파제 활성을 표 6에 나타내었다.
[표 6]
이상과 같이 본 발명의 실시형태 및 실시예에 대하여 설명을 행하였으나, 전술한 각 실시형태 및 각 실시예의 구성을 적절ㅎ하게 조합하는 것도 처음부터 예정하고 있다.
금번에 개시된 실시형태 및 실시예는 모든 점에서 예시로서, 제한적인 것은 아닌 것으로 여겨져야 한다. 본 발명의 범위는 상기한 실시형태 및 실시예가 아니라 청구의 범위에 의해 표시되고, 청구의 범위와 균등한 의미, 및 범위 내에서의 모든 변경이 포함되는 것이 의도된다.
SEQUENCE LISTING <110> Sumitomo Pharma Co., Ltd. <120> Antisense nucleic acid <130> 9220355WO01 <150> JP 2021-090359 <151> 2021-05-28 <160> 236 <170> PatentIn version 3.5 <210> 1 <211> 76 <212> DNA <213> Artificial Sequence <220> <223> WRN Exon27 <400> 1 ttcgaaaact gtatcttcgg gcaccaaaga gcattgttat aatcaagtac cagttgaatt 60 aagtacagag aagaag 76 <210> 2 <211> 142390 <212> DNA <213> Homo sapiens <220> <221> gene <222> (1)..(142390) <223> Healthy person WRN <400> 2 gcaggaacgg gggcggggac ggcgctggag gggcgggtcg ggtaggtctc ccggagctga 60 tgtgtactgt gtgcgccggg gaggcgccgg cttgtactcg gcagcgcggg aataaagttt 120 gctgatttgg tgtctagcct ggatgcctgg gttgcaggcc ctgcttgtgg tggcgctcca 180 cagtcatccg gctgaagaag acctgttgga ctggatcttc tcggggtaaa gtgtcttcct 240 attcccgttt tcccagctcc gtgccccggg gtatctatag tgctaggctt ctgagacacg 300 tggaggcgct taggcccgcg gagcaggccc ctgggctgtg tttgggagat tctggaaaaa 360 cagactttct cccttttcct ttcccctctg gagcagctgg gaaaggcgtc tctcggagct 420 tccgccattc agaaagtgtt tccccgcccc tgacggcccc agcttgatgt ttaccttgcg 480 cgcttagtta ggattgctct ttctagtacg gcctttatta tggcagaaat tgagccacta 540 caggtctgca cagcaaagtc gagggaaata acctgctgtc tatgatttag caagtgatga 600 tggatatttt tgagttcaaa tcactcagtc tttaatggat tttcttttct ttttttccta 660 gttgaatctc agttgttctc aggctaggtt tgatatgaaa aatactactc cctattgaag 720 agggtaatat aattcttagg atgctaatac aggagtctgt aagtcggagt acttcaggct 780 ttttatggtt cggtacattt ctttttaggg gtgggatatt gggataagta ggacagttca 840 gatcttgatg tcattgaata gtggtgtcta cctaaaagga agaggctggg gcacaaaatt 900 ataatttaaa gtgtttactt cagccaaaat gaggacagct gcccaggact catttcccag 960 ttgccttggg gagtgctcct tcagccttgg ttacaagcag gtttttaaag gcgaagggga 1020 agagtgggct gagacaaagt tggtcaggaa ttgttattgg tttacagaga taccattgct 1080 tagtgattgg ctgtacactg taactcatag ggtatgagtt atcgtgtcca gcatatggca 1140 ttttatggct tcttggttcc agtctagagc ccatatagca ggtgggcttt aagagataat 1200 tatccagctc agaccgggag tgagacggga ctgttttttc attctaatgc ctctctgggc 1260 ctgataattt aaaggggctt gcattcttca gctaaaattt tattttcttt tatttttttt 1320 cccccacagt ggtctccctt tattaatcca acaaatgttt attaaggact gctctaggca 1380 ctagagatac caacaatgaa caaaacagac aaacatctct ctccttttgg agcttacatt 1440 ttagtggaaa gagacaggca aaaagtaaaa ttataggatg acagaaggtg aaaatagaga 1500 ttaaaaagga aagggggatg aagagtgtgt gtgtgtgttg tgggtggggg gctgtaggga 1560 gctgcagttt tacaataagt ggtcagggac gtcctcgctg agaagggaat ttttgagtcc 1620 agagctcaag gaagtgagag aacttacctt gacgttctct ggaggagaag aaagtacaaa 1680 ggccctgggg gaacctgcct ctttatgttc agagagcaac ttaagaggcc tagtgagctg 1740 gagcagagcg gagaggaggt cagaggtcag gccagaaagg gaaaggggcc agaatgtgta 1800 ggactttatg ggctatattg aaaattgggg ctttcattct gagggagatg ggaagctgtt 1860 ggagagttgt tagggaaacg tgatctgaat tatgtttcta aaaaattgga gtaagatatc 1920 ataaaatttg ccatcttagt cttttttgta tctggccaat tccactcaga attctttttt 1980 aaacagcttt attgagatat aattaatata tcatatgatt cactcattta aagtgtgcaa 2040 tacaatggtt tttagtttgt cttcagagtt gtacaacctt tatcacaatt acctttagga 2100 ctttttcatt acccaaaaga gaatctccat aaccattagt actcaatccc acccgctttc 2160 ctagcaatca cttacctatt tttttgtctc tatatagctc tcaaacccta tgatattcct 2220 tctatctaac tgtatttttg tactcattaa cagcctctct tcattcccac cacccatcca 2280 tcccagcctc tggtaatcac cattctactt actacctcaa tgacatcaaa ttttttagct 2340 cccacatata agtgagaaca tgcgatattt gtctttccct gcctggttta tttcacttaa 2400 cagaatgtct tccagttcca ttcatgttgc tgcaaatgac aggatttcat tctttattat 2460 ggcttaatac tattccattg tatatgtata tcacattttc tttatccact catctgttga 2520 tggacagtta gcttgattcc atattctggc tattgttgaa tagtgctgca ggaaacatgg 2580 aagtgcagat agctctttga catactgatt tcatttccct tgaatatata ccctgtagtg 2640 gatttgctgg acccgcttgt agttctacat ttaatatttt gagttatttc cataatgtta 2700 gtaataattt acattcccac caacagcgag gaaggagttc ccttttctcc acatcctcgc 2760 caacacttat cttttgtctt tttggtaata gccattctaa caggtgtgag gtgatatctc 2820 attgtgattt tgatttacat ttccctgatg gttattgatg agcaatgttt catatacttg 2880 ttggttattt gtatatctcc ttttgagaaa tgtctattca ggtcttttgc tcatttttta 2940 aatatggttt tttaattttt ttattttttt gctattgagt tgtttgacat ccttaaacat 3000 tttggaaatt aacctcttat tagatgtata gtttgcaaat attttatccg attctgtaga 3060 ttctgtcttc agtctgttga atttgctgtg cagagaagca ttttattttg atgtaatccc 3120 tttgtctatt tttgcttttg ttacctttgc ttttgaagtc atatccaaaa aatcattgcc 3180 cagatcagca gtccccaacc tttttggtac caaggactgg tttcatcgaa gacaattttt 3240 ccatccacag gagggagggg atggtttcag gatatttcaa gcgcattaca tttattgtgc 3300 actttgtttc tattattatt acattgtaat atatagtgaa ataattatac aattcaccat 3360 aatgtagaat cactgggagc cctgagcttg ttttcctgaa acttgagggt cctatctggg 3420 agtgatggga gacagtgaca gttcataagg cattaggttc ttctaaggag catacaacct 3480 agatcccttg catgcgcaat tcacagtagg ttttgcgctg ctatgagaat ctaatgccac 3540 cgttgatgtg tcaggaggtg gagctcaggt ggtaacgtga ggaatgggga gcagctgtaa 3600 agaaaaatga agcttcgctt gcttgcctgc tgctcaccta ctgctttgtg gcctggttcc 3660 taacaggcca tggactggta ctaatctgtg gccctggggt tgggaacctc tagccctgac 3720 caatgttagg gagctttttt cctgtgtttt cttcaagtgg tttcatggtt tggggtctta 3780 catttaagtc tttagtccat tttgagttga tgctgtatgt ggtgagagat aattgactac 3840 tttcattctt ttgcatatgg ttatcagttt tcccaacacc gtttattgaa gagcctgacc 3900 tttccccatt gtgggttctt ggctcttttg tcaaaaatca gttggctata aatatgtggt 3960 tttatttctt gggtctctgt tctgttctat tatctgtgtg tctctttatg ccagtaccgt 4020 gctgttttaa ttactagagt ttagtatatt ttgaagtcag gtagtgtgat gcccctagct 4080 ttgttctttt agctcaacat tgctttggct attcagagtc ttttgtgagg ataatgtttt 4140 caaggttcac ccatgttgtg gcatgtatca gaactcgatt tctttttatg gctgaataat 4200 attccatttg tttatattat atatatgcca tatttattta ttcatatgtt gatggacact 4260 taggttgttt ccaccttttg gctattgtga ataatgctgt tattaacatt ggtgtacaag 4320 aatctgtttg agttcctatt ttcaattctt ttgggaatat acctacgtgt ggacttacta 4380 gatcacatgg taagctttta gtttagcttt ttaaggaact gctaaaactg tttttccatg 4440 ggagcagtgt acaagtgttc cagttctcca tatgctcacc aaaacttaat ttcctttttt 4500 aaaaattata gctatcctag taggtggtgg gaagtggtat cttactgtgg ttttattttg 4560 tatttcttta atgactaatg atgttgagca tcttttaatg tgcttattgg ccattatatg 4620 tcttctttgg gaactgtcta ttaagtcctt tgcccatttt ttaattgagt ttttttttct 4680 gttgaattgt gggagatctt tatatattct gaatattaaa cccttattgg gtgtatgatt 4740 tgcaaataat ttctcccatt ttgtgggttt tcttcacttt ttgatattgt tctttgattc 4800 acttttaaat ttttatagag tccagtttat ctgttttttc ttttattacc tatgcttttg 4860 gcatcatacc taattcccaa atccaatgcc atgaagattt tctgttatgt tttcttttaa 4920 tagttttata gttttacttt ttctattgga gttttaagta aattcttgta tattagtgtg 4980 atacatttta agttattttt gtatatggtg tgaggtaggg gtccaacttc actcttttcc 5040 atatggagat ccagttgtcc cagcaccaca tgtttaagag tctattcttt ccccactgaa 5100 tggacttggc acccttgtca aaaatcaatt ggtggtaaat gtatggattt actcctggaa 5160 tctcaattct attctattgt atttatattt ctgtccttat gcctgtacca cactgttttg 5220 attacagtag ctttgtagta agtttagaaa ttgggaaaca tgagtcctcc aactttgttc 5280 ttcttttcaa gattattttg gctatttggg gtcccttgca attctgatga gtttgaggat 5340 caccttttcc atttctgcag aaaagccttt tgatagggat tgcattgaat ctgtagataa 5400 ctttgggtag tattgacatc ttaacaatat taagtctttc tatgcataaa catgggatat 5460 ctttccattt atttgtgttt tctttaattt ctttcagcag cattctgtag ttttcagagt 5520 acacgttttt cacctccttg gttaaattta ttccttggta ttttattctt ttagctgcta 5580 ttgtaaatgc agttactttc ttagtttcct ttcagattgt tcatttctgg tgtataacaa 5640 cagctgatat ttcaacgttg atgttgtact ctgaaacttt gttgaattta cttattagat 5700 ctagtagctt tctttgagat ttttatatgg gattatgtca tctgtatata gagatagttt 5760 tacttcttcc tttccattat ggatgccttt tatttctttt ccatgtctaa tttctctggc 5820 tagaactttc aatatgatgt tgaaaagcag tggtgaaagt gggtatcttt gtcttgcttc 5880 ctatcttagg tggaaagctt tcagtctttc accattaagt atggtgttag ctgtgggttt 5940 tcataaatgc cctttatcat gttgaggaaa taccctttta ttcctagttt tctgagtttt 6000 tatcatgaaa gggtgttgga ttttgtcaaa tgccttttct gtgtcaattg aaatgatcat 6060 gtatttttcc tcccttatct taatgtaatg tgttatattg attaattttc ttatgttgaa 6120 ccacccttgc ctttctgggg taaatttcag tcacttatgt tatatagtcc tttaaattgt 6180 gttatcttat aacagaatca ctctgctact gttttgagca taggccatag ggaaaagcag 6240 gtaaaaggta atatggcttg aaccaacatt gtagcagcgg aagtggtgag aggaggtcga 6300 attttggctt tgttttgaag atagaaccaa cagtatttgc tgacagatta gatgcagaat 6360 gtgaaaggag gagatgagtc aggatgaatc caaggctttt ggcatgagca accagaaaga 6420 tgaaggtgac ttactaagat gggaaatata caaaaggagc agtttgggga aactttatat 6480 ctattgagtg gaatatgcca attagagatt caaatatcca gtaaataatt ggctatcaaa 6540 gtttgaagtt aagaggaatg gtctaggctg tttatataac tttggaagtc attagtgtat 6600 aacagctaat ttaaaagcca gcagactcta agggagtgag tgtagaggga gaagagtaga 6660 ggtctgtgac ttgaatcctg gaatgctgtg atgtttagag attggggagg taagaaggag 6720 cagcagagta tactgaaaag ggattgttat actgaaaagg gattgatata gatggagact 6780 caagaattat cacagaaacc tgataaaatg tttcaagaag atgggtgtga ttaattgtgt 6840 cacttactgc cggtacattg actcagatga gcgttgagaa ttggctatag gatttgacaa 6900 cataaaagtc attggaaacc ttgacatgag cccttttcgt ggagtggagt ggttacagtg 6960 ggtttaagag aggattaaag gagtggaaac agagatgcta ttatagatga ctcgtttgag 7020 tagttttcct acaaagggga gaataataat ggagcagtta gccaaaagtt gagttttttt 7080 ttcttcttct tttttttagt tggaaaaaat tgcgtatatg ttgatgggtc ttttctggca 7140 gaccagtaga gaggaaaaag ttgatgatgt aggagatggg aaaatgtctt tgagtagatg 7200 tcttcgagaa aatgtctttg agtagatgag aggtttgcac acatggagag gttggatgta 7260 ggagtactga tagttcatcc atagttacat aagaaaaggt agatgtatta gagttctcct 7320 gagaaacaga accaatggga gatctttata tctctgtgtc catctctatc tgtatttctg 7380 tctctgtatc tatgaagaga ttataaaagt tttaagatct gccaggagac atacccacgg 7440 gagctaatgg tatagttcca ggccagttgt gaaggcctga gaaccaggag agcctatggt 7500 gtaagttcca gtctgagtcc aagtctgaag gcaggagaag accaatgtcc cagctcaaag 7560 acaggcagag ggagcagatc ttcccttact tagccttttt atttattcag gccttcaaca 7620 aattgaaggc ccacccacat tagggagggc aatctgcttt actcagtcta ctgaatcaaa 7680 tgttagtctc acccagaaac atcctcacag acacacccag aataatggtt agccaaatat 7740 ctgggcaccc catggcccac tcaaattgac acataaaatt aaccaccaca gtagagtata 7800 tgggtacaaa tataattatg tgatatagat ttcagggtaa gagcctgtgg aaattcattt 7860 ttgattgctt ctagtgaaat cggaagcaag atcatcagct aagagtgacg atcggtggag 7920 gagatatgaa gtttaagtgg agaggagaag gtataaaata gtcttaggag gggaggatag 7980 taaatagatt agggaaaagt tgtaggattg ccaggaagta gtaagggccc acttgaggct 8040 ggtggtcaca aatttaaggt gagaccagtc aaaatggttg tgcttttcac ctgctgcatt 8100 cattcagctg cataggtaca ggcacagagt aggtcaagag ttctttttta ttcggggtta 8160 gagttttgcc aggagatagt aataaagcca gaagggcaat gaatttgagg gagtatgcaa 8220 ggaagtggct gttaacttgg agtttaaact agtcaagaag agaattaagg actgcccaag 8280 gggtgaggac aatgatatgg tagcagggcc cttaaaagcc ccagttagat gaaaagattg 8340 ttggaattga gtttctagag ggaatgaact tgaaaaacag gaggtgttgg ttggagagtg 8400 ggatatatgg aattgagatt atggaaggat tcagtcgttg gtaataacat agtatctttg 8460 taggaataaa taggtggagc aggatgcaga caagatcact ggaggagggc tggtcagaag 8520 actgggaggc actatctccc ttggatatta tacatcaaag cttgtgatct actagacaag 8580 tagtggggaa agggtaggat atagatatta atggctatag ttttgatggt gatggtcatg 8640 gtgatgatga tggtccatta acactcaact caaataccat caatttgatt tatatctaac 8700 accacaaagt taggtgttga gttacatgtg gttatattgt aactaatagt cagcccttca 8760 tggacttcta ttctttgatg agactcttct tgtaggagta gtaggtgcct taaagcacct 8820 tttcatagtt gtcagattga aatccttcac cagtgtttta ggttaaccct gttactgtgg 8880 aagtttctct tggctttctg tgtgggctgc ttctttgtct agttttacct tttggggtta 8940 gcatactatt gtgaataatt tattggtgag aaggtaagca gagaagtaga gtactctatg 9000 acctagtaat ttcatatcta ggaatctatc ctatagaaat gataggaatg ccttacaata 9060 cccacatatc cacaagggta ttcattgaac gttatttttg gtgaaattcg caagcaacct 9120 aattatcatc aatagggaat tgttaaatta tgatagataa aatggaattc tattcagtct 9180 tcaaaaagtc agatcaagaa gtggtcttac attttaatta tcccatcctg tcaacaagag 9240 tgtcttcagt tgcaagtaat ggaaaaacca ttcaaactga cttcagcaat aaaaggttat 9300 ttattggtct gtttcatgga gacatctgag gtagagtggc cttcaggcaa gttcactcag 9360 ggatccgact atttttctgg ccttattctt ggccctcttc tatgaaaaca ccttcagggt 9420 ggtttcttgt atgcttgtaa gatggctact tgcatcaacc atgaccacat ctagcaggag 9480 caaaagcatc ctttcccgta ccagaggaga gtcccgaaat ttgttgcaat tggactgcct 9540 tggaagcaat aattatggcc aggagatgga ggctagagaa ctgagacctg atcatagctc 9600 ctatccttga atcagttgta tagcaagggg aattggattt tccttaagac agttggattt 9660 cacctgtagt cttggtgatg aggtcagttc catccataaa actttgctgt tacacatttt 9720 gggatggggt gaggagggct gaatggagat taggatgcta ttgaaatttg ctgtacacaa 9780 tggatcatta tcgtcttctt tcttagtgtt aaggtaatca gcctcttttt cctcctccta 9840 tgcttgactt tactaaaacc atgagacatg tttaacctca ggactccaat ttgaaaaaat 9900 atagactgtt atttacttta ttacttacag aagcccttca tactactctc agcaagaaag 9960 aggtaggcag ggagtgaggg aggggggatc atgcttactg agaaacaaac tatcgagtat 10020 tgaaactccc ccttcatatg cctgacctca gtcccattca gttaccagta ggggccccta 10080 ttaattggta cctcaccagc ttttgctgtt cgttcataaa actgagtcat tgaagtacag 10140 tagaaaaata attggactac aagataactt atttccttcc ataattgcaa aatatctgat 10200 ttttcttctt gtttgtatta tgtaaactta ccctgtctga gggtcctcct ggattgttct 10260 ttgcatttat atatacatag aatttcattt tcttttttct tgtttttttt ttagacggag 10320 tctcactctg tcgcccaggc tggagtgcag tggcacaatc tcggctcact gcaagctccg 10380 cctcccaggt tcacgccatt ctcctgcctc agcctcccca gcagctggga ctacaggtgc 10440 acgccgccac acccggctaa ttttttgtgt ttttagtaga gacggggttt caccatgata 10500 gccaggatgg tctcaatctc ctgaccttgt tatctgcccg ccttggcttc ccaaagtgct 10560 aggattacag gcgtgagccg cttgcccgac cttctttttt tttttttttt ttttttttga 10620 gacgttgaga tagagtctca ctctgttgcc caggctggag tgcaatggca cgttttcagc 10680 tcactgcaac ctccacctcc caggttcaag cgattctcct gcctcagcct cctgagtagc 10740 tgggattaca ggcgcccgcc accatgctct gctaattttt gtatttttat tagagatggg 10800 gttttaccat ggtggtcagg ctggtctcga actcttgact acgtgatccg cctgcctcgg 10860 cctcccaaag ttctgggatt ataggcgtga gccactgtgc ccggccaatt tcattttcta 10920 ttttgaaatt taaactacca ctgacacttc gttttccctc tgttttactt agcatttatc 10980 ttagagaata atcttaatat gtatagttct attttattct tttactggca gcttagtatg 11040 ccatattttg gatgtgtcat tgtttattta cctattaatt taccctataa ctgcttccca 11100 tatttttgct tttacaaagg gatgtaatga acatccttta catacgtctt tgtgcatatg 11160 tgcaaatatt tccataggat agatgtaatt actgacttga aggttatgca gatttaaaat 11220 tttgatgcct tctatgaaac atctttcaaa atggtgatgc cagtttcttc tctcgtaatt 11280 actgcatatg gtcaatcttt taaatttttg ctggtaatga tatttcaaaa ttataaccag 11340 ttttttggcc tcatttcttg aataacttgt tttttctcaa agataagaaa tgtctccttc 11400 atcgtatgtc aaatttccat atttacatgg atctatttct ggacatggca agttttattt 11460 atttattgta tgtatttacg gtgtacaaca tgatgttttg atacacatat acgtagtgaa 11520 atgattccta cagtcaaaca aattaacatg ttcaccacct tccatagtct ctgcagtctt 11580 caaggttttc tctatatggg attagacatg ctatgtctga tctgtttttg tatttttaca 11640 ccaattccac actaattttt tttttttttt tgactgggag tctcgttctt attgcccagg 11700 ctggagtgca atggcatgat ctctgctcac tgcaacctcc gcctcccagg ttcaagcaat 11760 tctcctgcct cagcctccct agtagatggg attacagcac tcgctgccac acctggctaa 11820 tttttgtatt tttagtagag atggggtttc accatgttgg ccaggctggt ctcgaactcc 11880 tgacctcagg tgatctgccc gcctcggcct ccgaaagtgc tgggattaca ggtgtgagcc 11940 acctcacctg gcacacacta ttttaattac tgtagtttta aaagtttcat atttagtagg 12000 gtgagttttt ccttgttggt cttgtttttc aaaaaaaatt tgctgctctt gagtattttc 12060 tcttcccagt gaactttaat gtaaactcac gtggttcaat gaaaaattct gatgactttt 12120 tttcttggta ttgcttcttg agtgtattga tttaattaat atatttacag ttttgggtct 12180 ggctgtgccg aaacgcagtg tgtcttatcc agtccttttt taactgtctt aataaaattt 12240 gctggttatc tttaaaatgg atcttgtata ttttatgtta ggtttattcc caggcaggtt 12300 gtcatttttg ctgttactga ttttggatat aaattttgga tataattgta taatttggac 12360 ttggatataa ttgtatttga ttctgtctta tatataaaaa tgagatagga taataattta 12420 tcctaggata aaaataattt gagtatcctt attttgcatc tggtacctta cttgctcctg 12480 ttaaacaaat agataaaatt acttgtcttc aaagagatcc tgtggaaaaa ttatttattt 12540 taggagactt tggagctttg ataaaaatta ggcttatctt ttgtaaaagc tggttagtga 12600 tagcaatcag actcttttaa aggtgatttt tttttctttc ctttgataaa atgcttaata 12660 tgagggagga ttaagaaaga ggatggcttt tgaacagttt cttcatgggg aaataagaaa 12720 ttagaataat ttcatgttct ccaaaaaaag gagaaaaatg accttccctc ctgagcctac 12780 ttcaagcctc tgtttctttc tgactctatt gttctcatct ctgcattttt ccaatctctt 12840 ctactgttag tgttttaggc tagctcctca gtggagggca gaaattcacc ttctctttag 12900 ctgtctttga aaccaagaag atagaggtat gagatcttcg tagtctgtag taagaataat 12960 agaagccatc agaaaaaaat atcaaagctt tgtagctgct cctggaagtt ttgatgtgaa 13020 gcaggagaca tcacctattg gtacctgact tgcttttgct gttcattcat aaaacagagt 13080 ctctgaaata cagtagaaaa ataattagac tggaggataa cttttttcct tccaggaatt 13140 acacaatcac aaaattgctg atttttcttc ttattcatgt tacataaact tatcctgtcc 13200 gaaaagactg tatttgaact tactatgtaa gatttgcttt aggtaaattt atggctgctt 13260 ccagaattgt gtattaattt tccagtttct tttttaccag tctccacttt tacctttccc 13320 tcttccccct atacttaaat tggtcttact gtaaaattta tgcgtttctc tttctacctg 13380 gcaatgctga tttttttttt tttttttttt ttgaggcaag gtctcactct ttcacccagg 13440 ctatagtgca gtggcaagat cgtggctcac tgcaacctcg aatccctggg ctcaagcgat 13500 cctcccacct cagtctccca agtagctggg actacagatg tgtgccatcg cacctggctc 13560 atttttgtat tttttgtaga gatagtattc gccatgttgc ctaggctgga ctcaagccag 13620 cctcctgcct tagcctccca aagtgctggg attgctggca cgtaccacta catccagcca 13680 gggctgagtt tctgaatcat cattgcagca agagaaattg gattaccttt agaccactgg 13740 ctctactgtg ggctgggagt gggacacctt ccttaaagcg cattggacat tggctttgtg 13800 ggtaactgat ctttacctga atgaaattta tcagtactgt attaagggtc tagggtggaa 13860 cggatgctag caaggcaacc gttaacatcc acttactgat gaatcctata aaattttatt 13920 tcaggccata cgaagtaaca gtaataaata taaaaggaaa aatagacaac ctaagcaact 13980 ttttaaattg acttacttga aaactttccc tgcaatttcc cggtttataa tggttgattt 14040 cagctgactg gctatagcta cttagagaac agaggaaatt cattaaaaat aatgaattat 14100 tcagttgggt agtgaaatcc agttataaag cacttcgctg tgccatggat tcagttcagg 14160 tcaagtgatg ttcctggttt atgggcagtg tggcttctca ctatgacaca gcaaagaacg 14220 tagcttttat cctttaccct tgttactaac taaaattaat ggcattttat tgtgtttatt 14280 tgtttgattc catttacagt ttatttcact tggttttatt agtacaaaat tgtgctttat 14340 ataatatttg acagttagga aaaattgtta gatacctata aagaaacaag tctctcaaaa 14400 atcatcctac tacttttaaa aattacatcg tcttactaca gttaacctag atgtgaatgg 14460 gtagttttat ttagcttttc tggtttgttt gcttggtctg tttggaggga agttaagatt 14520 agcagaaatg tagtaataga ttcatgaaag tcttgaaagc ttctttaatt agagaattta 14580 atgagggctt tggcatgcat tctttggttt ttctctgttt tcctctaccc cttcttattc 14640 tttttggttc attgaaaagt agaaagaaat tctcaaaaac cgtacaggag aataccttat 14700 aaatgatatc ttctgcaata aactatagat tgtatatatg tatatgtatc tagatacaca 14760 atctgtgtgt gtgtatatat atgcttgtgt gtgtataaat gtataaatta gttactagta 14820 tatacgtaag tataaaacct caatgtgcaa ggttacattt tcagaaaata tgtaatataa 14880 taaaagaaat caagcccaga atttttaaaa agtttattgc gctttctgtt aaaaatgaaa 14940 ggctttttga ctggaagctg cttctcagta aaaataacat aattgtgttg gtgaagccca 15000 aagattctaa tgaaaattag ggtattgaca accaaacgga attgctggag tacttaagct 15060 gctttggttt tgtaatcttt ctgtgtcaga atatttgaaa aacacttatt aatccagtct 15120 tgtaacttat ccttgaaatc tcttttttaa tattcttttc cacacacatg aaaagttaga 15180 tgagtgtatg aatttctgtt gtcagactag ttgtaaacct cctaaatata gtttctgcag 15240 tatagttaaa gagaaagaac atcctggcta acacggtgaa accctgtctc tactaaaaaa 15300 aaaatacaga aaatgagccg ggcatggtgg tgggtgcctg tagtcccagc tactccggag 15360 gctgaggcag gagaatggcg tgaactcagg aggcagagct tgcagtgagc cgagatcacg 15420 ccattgcact ccagcctggg cgacagtgcg agactctgtc tcaaaaaaaa aaaaaaaaaa 15480 aaaaaaaaag aaagaaaata ggcccagcaa ggtagctcac gcctgtaatc tcagcacatt 15540 gggaggctga ggtagggagg attgcttgag gccaggagtt caagaccagc ctgggcaaca 15600 tggtgaaact ccatttctac aaaaaataca aaaattagct gggcatggtg gcatgtgcct 15660 gtagtcccag ctacttggga ggctgagtgg gaggattgct taagcctggg gaggttgagg 15720 ctgcagtgag ctgtgactga gcaacagagc tagactctgt ctcaaaaaaa aaaaaaaaag 15780 agatgggttt tgaaattcag tacttttttt gagtgaggtc caatgggtca gaaagaagca 15840 ttggataaat gaatccattt tctcttctct gtttgaattt gtaatttgaa agaatattct 15900 acctataaag tacttcagtg cttaattagc tgtcagtgaa tttatatatc ttatctaatt 15960 catatggatt tgctattttt atctgtacct acagattcct gacctctcta aggggatccc 16020 agtatactat agggaatgag gtataataga agtaaaagac ctatcactag tcctgtcatc 16080 attccaactc atgtgtaatt atagtttaaa agaagtgaca tcatgtgtat tgctgtttat 16140 ctttacatta atcttgtggt caagaaagca aatactataa tatataataa ttatataata 16200 tcataagaca agtaatataa taatgggaat ataatcccat tttacaaatg aggaaatgaa 16260 aatttagaga aataaagtga cttgtccagg gtcacatgga tactaagtga ccaagtgtca 16320 aagcagaatt ttccaaataa cttaaagata attcttgtac aaatatagaa cgaacacatg 16380 tcatatgtgt tgtgttaatg agggaaccag aaggatgaca acattggttc agagagatgc 16440 aaagataaat atagacattg gaggaaaaag ttggaaataa gattgttagg ttagatacaa 16500 agctgtgtta taggccaata aaaaccatag actttgaggt tatctttttt actggacagg 16560 attcagttac acctttatga gaccaaaatt tattatttaa catgtggata ttagagtctg 16620 agttttaaaa ttattagtaa atgaccgtca aataaagata tgtcccctaa tgaaatactg 16680 ataatcgctg ggtgagcttg tgctcctata tgacattgaa atgacatact gccctctctt 16740 tgtcttctaa gttttggata cttttttttt tttttttttg acacaaagct gcattagaac 16800 ctaggtttct tgattttcag tccagatttc tttccactct acttcctgct tcttcatagt 16860 ataattttca acactagagc agtctgcata acttttgcaa aatcagctag tctttcttat 16920 tagttttcct ttgtgcaaag tgatgtagat acagctttct tcttcagaga aacattgtga 16980 aattcaatga atatttgtaa aatttgcata cgtgcccaat gtgagaaatt gaaattatta 17040 cttaagtatt gcaactgttc ttttaggata ttttgtttgc aaatttcaga gtaattataa 17100 atattcttgc atttttattg taatcagtat ttataaaaca gtgtatttca tcacattaac 17160 ctttacatat tttgaataaa atagtattga accattttaa atagtaagtg gaaatttttc 17220 cacattaaac agtataacgg gctaacagag ttaagcattg cattatttaa ctaataattt 17280 tttcctgaac ttcagattat tatctgtatg tgtcatataa cttgacaatt tttttttttt 17340 agtgcttttt aaaaagagtg ggatacttta ttcagtttag ccctcaagca attaggcaag 17400 tcagttacca tggtaacagt aggtattaat ttccttacct agttagaggt tttatgaaca 17460 aagaaatctc tgagttcatc caccaaaacc caactttctc ttgagactgg cctcttgaga 17520 ctggtgttaa atttgtctat tttctagaag atgacactat tctaagtgga aaatacggtt 17580 ctcttgaggt gaatttctac tctatcaaga gtgaagtaga gtatggctta aaagttaagt 17640 gattaaaaag ctaccctttc ttagctaatt tggaatgtaa ttggtcttaa tttttctaaa 17700 ttcgttctaa ccaaaatctt attggcgtga tttctattga catgaactag aagtgacttc 17760 agcagacaac ttgtcccaat atctaaatgc tgtcaaatag aatcacttaa gatgaatttc 17820 ttccaaaaca gagttcacaa ttttgacaga taatctctta gcatttaatt gactagtatt 17880 accaacctta tggaataggt ccactcgttt agctatcatg aggaccattt tgcaactaac 17940 ttatcaaaaa gccttcacca agaagttgca tatcttattg atattttaga atgcgattat 18000 ggagattaaa aatcaccaca atgggttgtt aataacgcca gccttgaact ttcagtttta 18060 gagcatttta tctgtgttct gtagtcaaag ttggtaaggt gtccagtggg tcatgtttga 18120 cttgctgctt gtttttgtac tgtgtgctaa atggtttcta catttttcag tggttgaaaa 18180 gtcaaaagaa gaataatatt ttatgaaatt taaataaatc caggtttcag tgtctatagg 18240 taaaatttca ttgtaacgtt gttatgctta agtattgttt atgacttctt tgctatagtg 18300 acaaacttga gtagttttga caaagatcat ctggcctgta aggcctagaa tagttactgt 18360 ctaacccttt agagaaaaaa attgctggcc cttgttctat agtatgaaaa aatatagcct 18420 tgattattca ttaaaaaatt attttcccat tttattgaca tacttttgtc ccctgattgt 18480 taaaaggaat gcatgttctt atagaaaagt tggaatatat agaaaagtat aaagaacaat 18540 atgaaaaacc atttgcaatt gtgagataac cactaatgtt ttggtataca ttgctccaga 18600 cttacacaca aacacacacg cgtatttatt ttatacaatt agagtctaat tttttttttg 18660 agacagtctt gctctgttgc ccagggtgga gtgcagtggc aagatttcag ctcactgcaa 18720 cctctgcctc ctgggctcaa gtgattcttg tgcctcagcc tcttgagtaa ctgggattac 18780 aggcgtgcac caccatgtcc agctaatttt tgtattttta gtagagacgg ggtttcgcca 18840 tatgcccagg ctggtctcga acccctggcc tcaaatcatc ggcctgcctt ggcctcccaa 18900 agtactggga ttacacacgt gagccactgc gccttaattt tttaatttgc ttttttcact 18960 tgaataatta taagaacatt atttttaatg actgtgtagt gttctgtttt atggatgtac 19020 catacttaat tatttagtca taatttatta ttatgaggtt gataaacatg ataatcagat 19080 tgagctcaag aagctagtta tagggttgca caattaatga atcccaggta cctcgctggg 19140 ttgctgaggc tgctattttt ttcctgcctg tttggaacac tgtgtttggg accaatgagg 19200 caaaagaaat tgaagagctg ccattttcaa ttattctatt agaagataca ttgaagattt 19260 gtcaaatgac atagacacaa cactaatcca gaagattatt taatcaaaaa ggcattcatt 19320 tcagatatga attcataaac atttgtaacg atcctcagtt tgaagaccat atagaatccc 19380 tgaagaactg gaagacacta tttgcttggc aaagagaagt ccccagacca actggggatg 19440 aaatattcaa agagataaat gaatactttg aaacatacaa ggtactatgg aaaaagagtg 19500 gaagtttggg acaggtaatg acaggaagat ataaaagctt tacattaagt tcaatctaaa 19560 actttattcc aagtaacagg ttgtcttatt catggagaag cagttgtaaa ttaaaacttg 19620 cctgtggttt ggaatttcac attaaatgat tacattaaaa attcaaatgg tgaacctaac 19680 taaatccaag ctcctacagt accttctttt cacctttagg tgaagaaatg cggtgagcta 19740 ttttattact gattatgtgg acagtccaaa ggaaggttca taagcgaaaa ggaaaaattt 19800 aaattattcc atgtgagcga ttcttacttt gcagatttgt tgaagtgtag ttactggctt 19860 caaaaagtgg tatccttaac tgacattttg aacacttgaa ttcactcaat aaaaaaatgc 19920 agtgatcatg tggaaaatac attaaggtat atgacagagt ttatggattc agagcaaaaa 19980 ttcagctttg gaaaagtgaa gttaaaatgg ttttttaagt gatgtttaat tggtgttatt 20040 tgaatcctaa agaagaatta atagtactag tagaggaaag tcagtgtgtc tgtgacaaag 20100 ctttagtatt attttgaaat acttgatata aaaaagttca cgtttactca aagcttactt 20160 aaatcatcag aataaattaa catgtttctt aattaaagaa aaggagaagc tattagactt 20220 aaaaaatttt tgcacccttg aaatacatac aatttgaaga gattaagttg ttggaatact 20280 ggttaatggt gaaaaaggag ttttcagtct atgaaagcaa agccttctcc tttgccattt 20340 gcttttttgt agtggttgct atgtagaatt cgaagaaaat attgttaaaa agtcttggtc 20400 aggagtagag tgtagcatga acccaatgca ttttaacgtt aataatgagg aaaaagggaa 20460 tgcatgataa tttcatcaag tcagaaaaaa atggaaaaag aaaaagagga aactgaagaa 20520 agtaactgat gaaagtaagg tgaaagggaa aacaactttt tataccacct gtgaatgaga 20580 ttaattttcg tttccatact gaaagacaaa tatattccaa ttaagccatt caaaataaaa 20640 aacaattttt ttttggtaag agatgggatc tcactatgtt gaccaagtta gtcttgaact 20700 cctgccctca atcagtcctc ctgcttcagc ctcccaaagt gctaggattt caggcatgag 20760 ccactgtgcc tggccaaaac caaaattaag caacaaaaca acaacaacaa aaattccaga 20820 cagcctttaa aataatgata aaggttgaaa aattgtagat agtggtaggt agataagatt 20880 tcaggaaaag tccaaagcaa atcataatac gttattttaa aggggggttt aaaatccttt 20940 aaaggtacaa tgtgaagcat tatgaaatga taaaatacat gttttttaaa aacattaatt 21000 ttattttaag ttccaggata catgtgcagg acgtgcaggt ttgctacata ggtaaatgtg 21060 tgccatggtg gtttgctgca cctatcaatc tgtcacctac atattaagcc ccgcatacat 21120 tagctgtttt tcctgatgct gtccctcctc caggacccag tgtgtgttgt tccccatgta 21180 ttctcatcgt tcggctccca cttataagtg agaacatgtg gtatttggtt ttctgttcct 21240 ttgttagttt gctgaggata atggattcca gttccatcca tgtccctgca aagtacatga 21300 tcgtgttcct ttttatggct gcatagtatt ccattttata tgtaccacat tttctttatc 21360 tagtctatca ttgatgggca tttggttttt ttccatgtct ttgctattgt gaatagtgct 21420 gcagtgaaca tgaacatgtg tgtgcttgta tctttataat aaaatgattt atattccttt 21480 gggtatatac ccagtaatat aattgtataa cccagtaata ggattgcagt gtcaaatggt 21540 atttctggtt ctaggtcttt gaggaatcgc cacactgtct tccacaatgg ttgaactagt 21600 ttacattccc accaacagtg taaaagcatt cctatttctc catagccttg ccagcacctg 21660 ttgtttcttg attttttaat aaacgccatt ctgactggca tgagagggta tatcattgtg 21720 gttttgattt gtatacaaaa aagatttgta tttctctact gatcagtgat gttgagcttt 21780 ttttcatgtt tgatggttgc ataaatgtct ttttttgaga agtgtctgtt catgtcctct 21840 gcctactttt taatgggatt gtttgttttt tttttcttgt aaatttgttt gagttccttg 21900 tagattctgg atatagacct ttgtcagctg gatagattgc aaaaattttc tcccattctg 21960 taggttgtct gttcactctg atttgctgtg cagaagctaa aagacatgat tttagaaaaa 22020 gacatgtcaa agtcatacat gctcaacgac atagcgagta catatgtaaa taaaaaatta 22080 ttttatgctg tgaatttgac cgaaaataac ctttacctcg tcaggaatta caatcctcac 22140 gtatggtaaa ggatttccct attgcaaatt attccacaac attaatgttc tgtgtgcttt 22200 ttatctatcc caagatacaa gtaaatttga caaagatatt aggtttgtaa acaaatttac 22260 gttcaaatct ttgcctggaa gtatctagat agaattttgc atgcaaaaga gtatttacat 22320 ctaaaaaatt acatatttca aattaaaatg attttagtgt tatagataga aggaaagagt 22380 tattgaagtt tatttctgtt ttggcagtgt aaatgaatta cttacaaaat tttagaagtc 22440 tacaggtgtt tttataaagt ttgtgttatt tgtggaaacc tcagttttct ggcattttgc 22500 caatgaggtc tactctaagt atagcagaaa tttgttttcc agctttataa atatatattt 22560 taagattaag aactgatttt acttatataa tctgggatca acttttggct tctcctgtca 22620 aggattttga atttgtgaca aaatatacac ttattgataa ccagtgacat atataaaatg 22680 ctttacaatt aataaagcat atgtatttta catatttttt cactacatat gacgcatgtg 22740 gcaaccccaa gagttgagtt gtacccatcg gcaaactttg atcatgattc tgtgaatata 22800 ggcaagcacc aattgcaggt agaacattct ttttttgagt cccaaaccgt gagaaacaaa 22860 ttacagaaat gtacctttct tttgcattag gacacgttgt agttttgtat gaacactcta 22920 gttttaagca gtatgtgcaa aaacattgca caaaggattt gtgtgttgat tttgggactc 22980 ctgtattatt aattatgtgg tttatttgac taccccacat tttcaagcat aaattaataa 23040 atccataatt ccaggcttat taacaataaa caatctagat agttgaactc tttcttgcta 23100 acattttcta gatatggact gtttggtatt tttctactaa taaagaccct tagtaagctg 23160 ccttctggtt tgatgtcatt gggatgttta ctgggaactt tggtggagat cttgcagtct 23220 ctctccccca gtggtgaaag aatgagttac aaaccagctt tccttcccag tgtacaatag 23280 cgatggagtt tgttctatat ggaaaatttg tttgataaaa gtattcttta aaattttttg 23340 ttccataaat tatcagtatt ttcagtttct gattcatgct tgggatagtt gctgcatatt 23400 gtttaatttt gtcagaattt atattgttaa atatcaaata cgacagacta ccctcaaatc 23460 ataagtagtt aatgtaatta acatcctgtt tcatcatgag actcttcagt gttacattaa 23520 aaactgctac ctcctgggcc gggcgtggtg gctcatgcct gtaatcccag cactttggga 23580 ggctgaggtg ggcgatcgga tcacgaggtc aggagattga gaccatcctg gctaacatgg 23640 tgaaaccccg tcgctactaa aacatgcaaa aaattagccg ggcttggtgg cgggcgcctg 23700 tagtcccagc tactcaggag gctgaggcag gagaatggca tgaacccagg aggcagatct 23760 tgcagagagc tgagatcgtg ccactgcact ccagcctggg cgacacagca agactccgtc 23820 tcaaaacaaa aaacaaaaaa caaaaaaact gctacctcct tattacaaat aggaactaaa 23880 gttgaagttt gaggaatttg ctaagaacta agccttgaac taaggctatt ttatttgagt 23940 atgagtcata tcagggtacg gatccatttt actattaaca aaacaaatat gttctgtttt 24000 ttttttttaa atgcacacac cacgtttgag agattcttat tcactgtatt ttctttaatt 24060 atacttgaat tttggtttac attgaggagt gccctcaaag atattaacag atttttaaaa 24120 aatcctctaa aaaactcatt cttagggaaa tttgttcact tactaggtga ggagcaaaat 24180 aaaaatcctt aatatagaag agctattatc tgtcttcaaa attaagtctt tgagtagatt 24240 tgtgaataaa tctaatagtt ttgctgaatt tacttagatc ttaagacaga ataatcatgt 24300 agaaaattta aaatgtcagg aattcataat gattcatata cccaaggatt ttcattgata 24360 gtgaggtaag gttattcttg agaaagactc aaagtcataa aataatagaa tttcgaaact 24420 accagaatta tacaagtcaa ttaaaatgac tgatttgttt taagaggaag aaatactaaa 24480 tgtataatta ttagatgcag catattgtat ctgttttgtt ttgtgattct agctcttata 24540 acctatgctt ggacctaggt gtcataactt actttaaata tgtatgtttg gttttcattc 24600 atattgacag tactacctct cagttttctt tcagatattg ttttgtattt acccatgaag 24660 acattgtttt ttggactctg caaataggac atttcaaaga tgagtgaaaa aaaattggaa 24720 acaactgcac agcagcggaa atgtcctgaa tggatgaatg tgcagaataa aagatgtgct 24780 gtagaagaaa gaaaggtatg ttgttcattg actattcttt tgggtgagaa atttaattta 24840 tatttgactg tgcaaagagt cagttgttac ttgtaaactt caagtcattg tttaggtcag 24900 agttgctgtt gtctaaatgc accaggacct agttgttgaa agggtaaact ggaataaact 24960 ttaattgggt ttacaaaatg agaattctta ctgtatattt tctctttttc gggttgactt 25020 taccagtttg ttctagttca gataatttag acaacattaa ctttgttgaa ttttttgttt 25080 gccagccggt cttcagcatt ttaaggcaac attattatta cagttgtaat acgaatataa 25140 ttaccagaga aaaaactcag gaaaataaat gcttttatga aaatgggatt agaggtttga 25200 aaataaactt gttaggagaa ataatttcac aatgggatgg ttttttcttt gttaagtttt 25260 ctttatgact tcattagttt ataaaacatt aattgataaa acttagaact ataaattgaa 25320 tgcttcagtg aactttatta tttcagtgaa catttgttat ttgatgtgaa ctttgtgcct 25380 gttttgaaat ttactaaact caaggcatgt gttcggaaga gtgtttttga agatgacctc 25440 cccttcttag aattcactgg atccattgtg tatagttacg atgctagtga ttgctctttc 25500 ctgtcagaag atattaggta agtgatttga atttcctgat tttatttgaa tttggaccct 25560 tagaaggtac tattatggta atgtttgtga atatactgag ttttacaggt gaggtgtgtt 25620 caatagataa ttatttctat gtatacacta tcaccaagtt ttacatttca aataaaagtc 25680 actgaattaa tttgtaatct gtcagtttgt tcattcataa gcttttctat tacttcagac 25740 agtttttttt taactttttt aatatatgtg ctgctgaagc gagcacgaca gttttttaac 25800 tttcagtact taagatgtta tatatagagc tactgaacat actgtgttta ttttaccaat 25860 ttagggaaaa agtgcaaaaa ttatttaacc tttaaatgca cctttatatt tcattaaaaa 25920 tatcaacata gtaatattga ataatggcta tgatcggctc tgttgtgtgt aattagtaac 25980 agttgtagca aatgatcctt aaaaaatgtt ctaactaaac attagaggcc aggcgcggtg 26040 gctcaggcct gtaatcccag cactttgtga ggccgaggca ggtggatcac aaggtcagga 26100 gattgagacc atcccggcta acatggtgaa acaccgtctc tactaaaaat acaaaaaatt 26160 agccaggtgt ggtggcgtgc gcctgtagtc tcagctactc aggaggctga agcaggagaa 26220 tcgcttgaac ctgggaggca gaggttgcgg tgagccaaga ttgcatcact gcactccagc 26280 ctgggcgaca gagtgaggct ccgtctcaaa aaaaaaaaat ccaaaaaaac aaccccacaa 26340 acaaacaaaa aacattagaa atgtctgtta gtacttttaa aggttgcctt gtaaaattag 26400 gactgcaata gtgcaatcta aggctctcaa agcataaaac aagtaataag gaattcattc 26460 agatattttc cgaggtggtt atacctgtct tttaaaaaaa aaattttgtt atatattggg 26520 ttaaaaaaag cagaggtgct gggcacagtg gctcatgcct ataaccccta cactttggga 26580 ggccaaggca ggaggattgc ttgagcccag gagtttgaga ccagccatag taagaccccc 26640 atctctacaa aaaaatttaa aaattagcca ggtgtctgtg gtcccagcta ctcaggaggc 26700 ctaggttttg ggcccgagag gttgaggctg cagtgagcct tgatcacacc attgcactcc 26760 agcctgggca acagggcaaa accctgtctc aaacagacaa acaaacaaac aaaaggcaga 26820 ggtaggttaa gctatttatt aatggtcttc tactggtata gatataagct agaaataaca 26880 ttcaagtgtt tttactttta ctacagttat ctggccactt tgggactcat tatactgaat 26940 tagtttcaca gaggaggtaa aatctgttgt ttatgattac atattaactc taccatttta 27000 ccttcagcat tgctgtagta tgtcatatct gaaggcaatt agcacaagtg acttgaagaa 27060 ttgtagtttt gatgacttat atgtatttta taaaaggcag gcagagtttt tgtgtttgct 27120 ttcccctcct ctggacactt taaatttttg ctaccacagg tttccaacaa tttgattatg 27180 atgtgccctt gtgtaatgtg gttggtgttt atttggcttg gagttcgttg aatttttttg 27240 atctgtgtgg gcttatacct ttaatcaaat ttgaaaaatg tcttcagatc ctttttcctc 27300 ccatcctgtt attcttttct ctttctggga ctcttagtac acacaagttt gattgcttga 27360 tactgtgtca caggccactg aggctctttc ctttcagtct tttcttcttt cttccttttt 27420 ttctttctgt gcttcatttt gaatagcttg aatagttttg tttcctgtct tcaagttcac 27480 ttatattttt ttcttctgta gtgtctggtc tgtttatacc atcctgtgaa tttctttttt 27540 agatactaca tattttgttt atctctagaa gtcccatttg gttcttaatt tttttttcca 27600 ttttggctct cattattcat gtttctttca aaattcttga acatatttag catattttta 27660 atagctgttt taatgtactt gtctgttaat tccattattc tagggttttt ttctttctat 27720 tggatgattt ttctcctgat tatgggttat attttcctgt ttattcctac agctgttaat 27780 tttttttttt ttaattaggc attgtgatct tactttgtgg aatgttagat tttattgttt 27840 tcctttaaag aaaggaactt tgtcagacat ctaagttacc tgaagatcaa ctttatgttt 27900 tgaagcttgt tttcaagctt gatcagggaa agtctacgtt tgcctttagt ctaaaggtaa 27960 tttagcccta taataagatg tgacccttct ggagtctttg tagactgcct ctggtgatca 28020 acgatctctt ctctgacttt tcagaacgtt aatgcctctt acctttgtgt aagtccgtcc 28080 taagaatcat tcagcttatg gttgtttgcc cagccccata gagttttagt ctatgcatgc 28140 ttgtcttcgt attctgcaaa gaccaaagga gtcccttagg gagatttctg gagctctttt 28200 cctgcctagc ttcctcctct ccagaactct gccccgtgag ttccaggtcc ttcagcttcc 28260 agggctctga actctgtctc cccaactcag tgctctcctt gggattcttc tccctgttct 28320 gttgtctgca atgggtccca ggaagaatgt ggggcaactg taaggttcac ccttcatttc 28380 ccttccctta gagatcatag tcctgtactg cctgttgtct agtatctgaa acagttgttt 28440 tatatgtttt gtccaagttt agatttgttt gtggtgggag ggtgagtctg gcctcccttg 28500 ttatatcatg ttggcctgaa gcagaagctg agtttctttt attttttaaa tatagtttca 28560 atttttaaca actattaaat aggcaagtat caacaacaat agataacaat ataatagata 28620 tgcatattcc tcccacttta tcaaatctta attttcttca attttttttt ttttttttaa 28680 tagggtctca ctctgttgct cgtgctggag tgacagtggt gtgatcttgg ttcgctgcaa 28740 cctccgcctc ttgggctcaa gtgatcctcc tgcctcagcc tcctgagtag ctgggactac 28800 aggcatgcac catcatgccc agataattta tatatatatt tttttataga gatggggttt 28860 ttgccatgtt gcccaggcgg tctcaaattc ctggactcaa gcaatctgcc tgccttggcc 28920 ccccaaagtg ctgggattac aggcgtgaac cactgcgcct ggcctgtttt cttcagttct 28980 ttattaagaa atgaaacagt aaaatacagc tgaagccccg tgtttgttct ttctgattct 29040 ccctctgtgc ccctctgaga taacttctat gagttttgtg catttttttt tctttttaat 29100 aaaaacaggg tcttgctctg ttatccaggc tggagtgcgg tggcgagatc atactcaatg 29160 cagcctcaac cttatgggct cgagtgatcc tttcgcctca gcctctcaag tagctacaac 29220 tactggtgtg tgctgccatg cctggctaat tttttattta tagtttttaa agacagggtc 29280 tcactatgtt gcccaggcta gttttgaact cctggcttct agtgatcctc ctgccttggt 29340 ctcttactta aagcactggg attacaggtg tgagccactg gctgctcaca tgttttttat 29400 aatagtactt aataatttta tgtctgaaaa tattatataa tgttattttg cccatttaaa 29460 aactttaaaa aatgctaaca aactgtgtac tctgtaactt gtctttttta ctcaacacta 29520 cgtttttgag aatttttctt gttgatctgt gtagttccat tttaactgtt atatcttact 29580 atgtttcatt atgcaacagt tggttcaatc cattctcttg ttaatggaaa tttagtttgt 29640 ttctaatttt tgccagtagg aacagtgttg caatgcatat tcttaaacat gtctgtacac 29700 atctgagggt ttcatttatt tgtgacaaaa cttgccaggt catagtgttt atgcaccttc 29760 aactagatat tgtcgttgtc aaagtttttt tccaaaagga ttttaccaat ttatacatga 29820 accaccgata gatatcctct taacacgtgg tattctgaaa cttaattttt accaatcaga 29880 tagatgtgaa atcacgtaga cttagtttgc atttctttga cttctagtga gaagtagtgt 29940 cttcacatat tttttggatt tttaaaattt attttttatt tttgtttttc ttagagacag 30000 ggtcttgaac ttttacccag gctgaagtgc agtgatgcga tcatagctca cgctaacctc 30060 gaactcctgg actcaagtga tcctcctgcc tcagcttcct gagtagctgg gactacaggt 30120 gtgtgccacc aagcccagct aatttttaat tttttttttt gtagagacat gctgtgttgc 30180 acaggttggt cttaaactcc tagtctcaag cagtcctcct gccttgactt tccaaagtgc 30240 tgggattaca ggggtaaacc accatacctg gccatatctt ttggatttat tggtcatttg 30300 gattttcttt tgggaattac ctgttcatat ttttctccat ttttctgctg aataatttgt 30360 cttttcttac ttatttttca agaaatttta catattttct ggctgttcat tgtcagttgt 30420 atgtgctcca gataacttga acagtctgtg gttgcctttt aatttttgaa ttatgtcttt 30480 agttatgcag aagtttaaaa ttttaacata aattaattta cactattttt ctcactttag 30540 catgagtcta tcagatgggg atgtggtggg atttgacatg gagtggccac cattatacaa 30600 tagagggaaa cttggcaaag ttgcactaat tcagttgtgt gtttctgaga gcaaatgtta 30660 cttgttccac gtttcttcca tgtcaggttg gtatctctac atttcatttt tatatggctg 30720 ataattgtaa tatgtcaact ttatccctat aaaattaagt tcttttatta gctggccgtt 30780 ctctcattat ctcaaattta tttaagtatt tatgttctac ctgattcact cacattcctt 30840 gttttattta attttcacaa catacctgtg aggcattgac attttttctg ttttagagaa 30900 gagaaaactg aaattttaag aggctaaatg accaggatat gtactgctat tgctagcagg 30960 agtggcattc aaactgatta ttttttcttg tcatttatca atcaggactg tttgctttag 31020 ttaagaaata ctcaaggtca atgtgtttct gaatttaaaa ttactgttaa atacaaattt 31080 acacataaac atggtatgta taagaagtag gacataaatc catcatactt gacagaactt 31140 atggaaataa caagaaaatg ttacagtttt tccccaggga ttaaaaatgt tgcttgaaaa 31200 taaagcagtt aaaaaggcag gtgtaggaat tgaaggagat cagtggaaac ttctacgtga 31260 ctttgatatc aaattgaaga attttgtgga gttgacagat gttgccaata aaaaggtaaa 31320 agcaatatat atataatttt catgatgaag attattttgt gttacacaga atgtactttc 31380 tatctgaatg ttagattttt ttttgaaaaa gcttgttata taatgttttt gtagcaataa 31440 aaaagttcca agtgaatgtt ctttaatgaa aacctttatt tatttattta tttttaactt 31500 ttgtttcaag atcggggtac atgtgcatgt ttgttacaca ggtaaacttg tgtcatgggg 31560 gtttatcata cagattattt tatcacccgg gtattaagcc tggtacccat tagttatttt 31620 tcctgatttt cttcctccct cctcccaccc tccacctccc acagtgtgtg ttgttcccct 31680 ctgtgtgtcc atgttttctt atcatttagc tcccacttat aagtgagaac atatggtatt 31740 tggttttctg ttcctgcgtt agtttgctaa ggataatggc ctccagtgcc atccatgtcc 31800 ctgcaaagga catgatctta tttatttttt ttatggctgc atagtattcc atggtgtata 31860 tgtaccacat tttttttaat gcagtctatc attgatgggc atttaggctg attccatgtc 31920 tttgctattg ttaaatagtg ctgcagtgaa catatgcgtg catgtgtctt tgtaacagaa 31980 tgatttatat tccttttggt atatacccag taatgggatt gctggggcaa atggtatttc 32040 tttctttagg tctttgagga attgctacac agttttccac aatggaaagc ctttagttct 32100 aatccatgtc ttggcataga gtttcttttc tttttttttt tttttttgag gtggagtttc 32160 gctcttgttg cccaggctgg agtggaatgg tgtgatctca gctcactgca acctccacct 32220 cctgggttta agtggttctc ctgcctcagg ctcctgagta gctggggtta caggcatgca 32280 ccaccatgcc tagctaattt tgtattttta gtagagacgg ggtttctcca tcttggtcag 32340 gctgatctcg aactcctgac ctcagataat ctgcctgcct cggcctccca aagtgctgag 32400 attgcaggcg tgagccaccg cacctggccg gcagacagtt tctttttttc tttttgagac 32460 agagtcttgc tctgtcgccc aggctggagt gcagtggtgc aatcttggct cactgaaacc 32520 tctgcctcct gggttcaagc gattctcctg cctcagcctc ccgagtagct ggcactacag 32580 gcgtgccacc acacccagct aattttttgt atttttttta gtagagacga ggtttcaccg 32640 tgttagccag gatggtcttg atctcctgac ctcatgatcc acctgcctcg gtctcccaaa 32700 gtgctgggat tacatacagt ttctttaagc aagccttctc ttttccttcc tcccagttct 32760 tggtactctt tcactttcat atatttgcaa atgtaaaatt gtgttttagg tgtatatttt 32820 taatccatgt ataccagtaa cttaaaaaaa aatttttttt tttttaaggg agagcataat 32880 ggagctcttg tgatacggtg ctcttagtgg aagtttggct atcaattcca tcacctgtat 32940 ttcacatatt ttattaatga agttcttaaa ttaaattctc atatttagcc aagtattcat 33000 ttggctggga ggtagaaagc ctactaacca actttttttc atgaacaata tttttaaagt 33060 ccaagatttt taatacctac attagggaaa ttctagaatt aaattcttac aatgtggact 33120 gcatatgagg cttttagtga cagggaattt gttgaaggct atctgtgggt tgtattttgg 33180 tataacattt cctaatttta tttgtggtat gttcatttga tatcatttgg taatacctga 33240 aaacaggaac tgattttact gtgttgcttt ttcatcattt ctagctgaaa tgcacagaga 33300 cctggagcct taacagtctg gttaaacacc tcttaggtaa acagctcctg aaagacaagt 33360 ctatccgctg tagcaattgg agtaaatttc ctctcactga ggaccagaaa ctgtatgcag 33420 ccactgatgc ttatgtacgt gcttaaagat ctttagaaat tgtgatgtgt tttaaaaaca 33480 ttattataaa tgactttaga aaaattttat tatagtagtg gcagaaactc taccaaaata 33540 ttttatatca atttggcatt gaaaaatgct taggaagaca tttagtgaaa ctattcattt 33600 tcgatattaa ttagcaagta ccaatcaaca gattgttcaa tgctagttta ttttcattgt 33660 catgaagcca aattaatgtc taatttgtat gttaaaaaat gtgaacttgc tgaaaacatg 33720 aaaggctaat aaatccaggc tgagcaagca taaatagtac tgatgatgga tttgatatat 33780 aaacaattca gaatgaaaat aattatagta cagtttctat tttaaaactg gccttatttc 33840 ttatatataa aatgtggtga aattttagaa aaattgcctc caaatttagc ttgttgctgc 33900 cattagatat atttttatat ttacatgttt gtatgtagtg aaatctgggc ttatctttat 33960 atatagcact attgtgtgtt ttttaagaaa tgtattttat tccacagtga atttgttttc 34020 tcctaactca tgctttcatt tgtagatgaa tattttattg tttctccttt gcatctatca 34080 aaggaatgga aactcctttg aattgtaacc agcaaacaat tcacttttgt tagggaaatt 34140 ggatgataat tttcctttaa aagataccgc caaacttgag actaacattc tcagctgatt 34200 taagtaggat ttctcttact agattgcatt ttgttagatt ccattttaag ttattttatt 34260 tggatattgt gtgtaatatt gagtgtgaaa aagtgaaaac aaacttttaa ggctcaggca 34320 cctttctcaa ttttcacaat tggtatgatt attaaatgag gacatattga tatttgtgtc 34380 acataatagg ttgaattcca tgtttgggtg ctttgtgaat cattctcttc gatttttctg 34440 aagatgggac ttactgtttt atttcggtga tctttagcat actttttaaa tttttctgtt 34500 tttttatagg ctggttttat tatttaccga aatttagaga ttttggatga tactgtgcaa 34560 aggtttgcta taaataaagg tatgttaaga tccataaata aaatgtgaat tcactctttt 34620 gtgaggttta tctccaaaaa aggcaatatt cacatatttg caaagcattt agtactataa 34680 cttcttgaat gtctgagcag tcctgacatt agggtgggat ccatcagggc ccaagatgag 34740 tgtttcatct ttgttacttg tggcaaagca gcccttactt cttttacttt gtagcattgc 34800 tatgtatttg gcttctagag ttggggcttt gtggctttct tattgcagtg acacaaccag 34860 ctttctccta gtctggagat tatacatcct tgctataagt atttaaaatg ctttctatat 34920 aatgctttaa aacatgtaag atggcttatc cccaagatgg tagctaataa acactaagtg 34980 ataaagtagg taaagatcta tttattcatt tattaaatat tgttggtcat tttacagtgc 35040 tttctaacat actgatttac atttctaatt ttcttctgtc atttttctcc aaaaataatg 35100 gtcatgtcat ccaacctcag tgctgttttt agaggtcttg ataagccagt gagagcagaa 35160 ggagccacgt agtagagtgg gtgagcccag gctttttgtt gcacagacca atgtgaatcc 35220 cagccatgtg acctgggatg tacctgtttc tccaaacatg gaatgtagat actagcataa 35280 tgtccgtttt accgttttat agaataattg tgaagactta aagggacaaa ctattcgaag 35340 catctgtatt gatataaagt tatcactatt ctcgtagctt ccttttggag attttaaatg 35400 attgtgtttg ttaagatgtt aattaaatta ggccattttg ctaaatgctc ttaaaaatat 35460 ggcatgactg cctcatataa aatgatatga tattctttat aattgtcgtt gagcctctgt 35520 gggtggcagg ccctccttta tatgttaagg tagaagagtc tttattctta cttctcctcc 35580 ctggagagcc acttcctatg aatgcctgct ggttctctgt agtcagaggt cttgtggctg 35640 taacttagag tcagtctcca tatccctggg ttctgcatct gtggattcaa ccaaccacag 35700 attgagaaca ttcaagccaa aaaaaaaaat tcacagtttt aaaaaaggaa aagttgaatt 35760 tcttgcatgg agtaccacat tgaatctata tgaatgaagt gatgcgtagg cattttataa 35820 ggtattataa gaaatccgga gatgatttaa agtatacagg acaatgtgta tagattatat 35880 gcaaatattg cagcatttta tataagagac ttgatcatct atggatttga tatcagtggg 35940 agggaggttc ctggaaccaa tccctcaagg atacagagga atgactgtat gttaattaac 36000 tgaggcaggt gatcggtttt ttaagctgat tagggaaaca gtatataaga acttacttaa 36060 ctcataataa aactaaaatt caacagggga gagttatgat tttttggctt tatggttgtg 36120 gaattgcatg taggttacat gtacaatttt gttacatgtg caattttgat gaaaatgctt 36180 ccaaggaatg tttatgatat ttttcactaa agtaacatat attaataaca cagtactgga 36240 agtcctggta tctgtgtact tgtcattgta atgctacatt atttgacctt cacttttttt 36300 cccctttatt acattatatg tgtgagtata ttgtgacatc ttgactcaga ttccagtgaa 36360 ttgtattagg ttggtgcaaa aataattgtg gttttggtaa tttttaatgg caaaaaccac 36420 aattactttt gcaccaacct aataactaag attaccatct ttttttcctt ccttcctccc 36480 ttccttcctt tctgttattc agccagaagt atcagcatca ctgttctctt attttcttca 36540 tgtacatatg gatgatattt tcgaatgacc acttttctct tttgcttttt attattagac 36600 tgtttttttc ttcttgttaa aggataaaaa gattagaaca taaaaggata tttacacatt 36660 gtttccccat tgacttattc ccaagatggt agctaaaaac accaaatgat atagtagtta 36720 aagatacatt gactcattta ttaaatattg ttgagcattt tacgatatgg gaataccgta 36780 gtgaacaagc caggcatact ctgtttcctg aggggcctac agttttattg gggatataga 36840 tgagtgaaga aagcaattgc agtgtaggga gatgagtctt atgtcatggg aaaacaaggt 36900 gctgtagttg acacaccgag aggcatctga cacattgggg gaaatattct agaatatttc 36960 ctggagaaag tgcaggtaaa agccagacct gaaacctgag caagagttag ctaaggccag 37020 gtgcagtggc tcacgcctgt aatcctagca ctttgggagg ccgaggtggg tggatcacct 37080 gaggtcagga gtttgagacc agcctggcca aaatggtgaa acaccatctc tactaaaaat 37140 acaaaaaatt agctgagtgt ggtgacgggc acctgtaatc ccagcttctt gggaggctga 37200 ggcaggagaa tcgctttaat ctgggaggtg gaggttgtag tgagctgaga ttgcaccatt 37260 gcactccagc ctgcacaaga gcgagactct gtctcagaaa aaaaaaaaaa aaaaagttag 37320 ctagctgaag agtataggaa agaatgggta caggaaatta caggtgccaa gttacagagg 37380 tgagagaaat tatggtatct ataggtaatt gaaagtaatt cagtatagtg aacattgaat 37440 agggctgggc ggatgaaggc aaagcagaaa aaggaaagca gatgggccat ggtaaggagt 37500 ttatatctcc tcccaagagc aatcgaagtg actgagagtt ttaaacacag cagtgaagtg 37560 aattacatta aaaaaataag aacttgggct ctagaataaa aaacggatat aggaggaagg 37620 caggagtcac agtaggaata tcttttggga ggctgtgaca ataatccaag tgagaagtaa 37680 tggcaacttg agtcggttaa ttgtgttgag aatggagaga agttgacagg ttcaaaattc 37740 atttttcttc tttttttgag tctcactctg tcacccaggc tggagtgcag tgatgcgatc 37800 ttggcttacc gcagcttcca cctcctgggt tcaagtgatt atcctgcctc agcctcctga 37860 gtaactggga ttacaggtgc ctgccaccac gcccagctaa tttttgtgtg tttagtggag 37920 atgtggtttc gccatgttgg ccaggctggt ctcgaactcc tggtctcaag tcttccgccc 37980 acctcagcct cccaaagtgc tagaattata ggcatgagct accacacctg acctcaaaat 38040 acatttaata gagcaagcat gagccactat gcccagcctc aaaatacatt taataaacca 38100 atggaatttg aggtaatgat gaaagacaca tgtcaaggat cattcctgtg ttgttggcat 38160 aagcaacagg gatgaaaagc attgaggaag agcaagattt tgggatgcgt tgtcacacag 38220 ttgattttag gtatgttaag ggagggagac ctgtaagaca gcaaagtgga ggtggtgcaa 38280 gaattagttg tgttggctgt agcacagagg acagtttgag ttaagagagt tgggactgag 38340 aatcccgagg aactcttagt gttgaacatt tgcgtggagg aggggacacc aaaggagttg 38400 ccatagacat cgaggaaatt aggaggtgtg gtgtgcagaa agccaagtga agaacatgtt 38460 ttaagtagga ggatgctatc aactgtttta aattctgctg agagtttgag aaactgagga 38520 cttagaattc atcattagat ttggcaatgc gccaatcatt tgtaatcttt taaacaatag 38580 ttttgctgta ctgggtagca aaagagtgat ttgaggagtg gtcatttgga gcatatgcta 38640 ttcaaacaga gaagagtcca cgggctttgg taacatgaag gtcctataac catagcaaga 38700 gaatgaggtg ggtggaagtc atattaacgt gaatagagga gtaggttaga tctgaggaat 38760 gtgggaacag agacagggtc tcattatgtt gcccagcctg gctcagactc gtggcctcaa 38820 gcgatcctcc tgcctcagcc tcctgaatac ctcgggtttc aggcctctgc atctggcttg 38880 aaaacaacat tttctcagaa gcttgtttta gttgttttag aaataacgaa ggcatgtgta 38940 aacaactgtt ctagaagctt agtttggaaa gggaacgttt attgatgcat ataacactta 39000 tatgttgggt gcttatgtgt caggcactgt tagagttgct cgggaaaatt tacaaaccaa 39060 gcaaaccatg ccccttcatt tcctttgggt gaagtgaggg agccatgtgg ttatctgaag 39120 gaagagctta gcaggattag agggaagaaa gtgcaaagcc tcctagggtg attggctggc 39180 tcttttggag gaacagtacc tataactgaa tgaaatgagt gagggtaaga gtggcaggaa 39240 atgaggctag aaaaggagct tgggccatat cacgtagggc ctcgtaggct gtgaatctga 39300 cttcatttct tattaatgaa aataaatacg atgatgggtg atgggaaacc catagaggat 39360 ttggagcaga agaatgatat aattaaaatt ttattttaga aatatttttc tggttgtcgt 39420 aagaggaaaa atatttagcc ccagggcatt ttggcagaga gttaggaggc tattgtaaca 39480 gcccaagcaa tagacaataa ttgtttggat taggcgggta gcaatagagg tgatgagaag 39540 tcgtagcttc tgtaggtatt tggaagatat atattgtgaa ggatttgctg atgaattccc 39600 tgtaaggggt gagatgtaaa gattcataga acattaagat attttggtca gatcatctga 39660 tcaatggaaa ggtcagttat agtggacaga ttatgagaag aacaggtttg ggtgagaaaa 39720 ctttagattt cagtgttgga tatcctaagt tttagatgat tattgatatc caagagatat 39780 caatatttgg gatcaatttg ggaaatatga tcccaaagtt caaggttgag gttggagatg 39840 taattcagat ccgatggtag ttaaagcagt gagactgaat gagataaaat agggagtgaa 39900 tgaaataaag agtaggtgtg atattgacct caagggcaca ccagcattta gaggttggga 39960 agatgaggag agagcagcaa agaggactgg gagggccact aatgaaggag ggaagtacag 40020 gaggtgttta gttctgaagc cacctgaaga aaatgtttgg aataggaaga agttgtcagt 40080 tgctttaaat cattcgggga ggttgagtga gatgagagtc tagaactaac agttaggttt 40140 gatggtgtgg aggccatcag taaccttttc tttctttttt ttttttgaga cagagtcttg 40200 ctcagtcacc caggctggag tgcagtggcg cgatctctgc tcactgcaag ctccgcctcc 40260 caggttcaca ctattctcct gcctcagcct ccggagtagc tgggactacg ggtgcccgcc 40320 accatgcccg gctaattttt tttttttttt gtatttttag tagagacggg gtttcaccat 40380 gttagccagg ttggtctcga tctcctgacc tcgtgatcca cccgcctcgg cctcccaaag 40440 tgctgggatt acaggtgtga gccaccgcgc ccggcccaag agtaaccttt tcaaaagcag 40500 ctttgctcta ctgatttggg taaaagctta gttgcagttg gtttgggagg aaatgggagc 40560 agaaaatttg agagagtgag tgtagacaac tctttcaagg aatttcgcta taaatgggag 40620 tagagatctg aagactgaat aattagcaaa ctgaaaagtg ggaagacgta attctcttat 40680 tatttcattt ttcttagtga aataagaggt gaagttctct gagtaatagg agggtcaaac 40740 aggtgttaga agttcacaaa gaaaggaaga ggtttgaaat agtcattttg agagtgggaa 40800 atgtagaaga attaacagtc attgctgagg gtgcgtttga aatctgtcat gagtttaaaa 40860 taacttgtgt catcatcgat gtgtttattt tcaactatat tcaactgctt gggtgtaggc 40920 atcaggtagg taaaaaaagt gggttttatt atgagtagag gttttgccac gtaattacca 40980 tggagggagg gaagagcaaa ggagttgaga gtatagatac aaaggaatga ttactgtaat 41040 gtgggtaaga gaggaatgga aggctcagtg ggcagtggga gtagggatgt tgataggtaa 41100 ggaaaaggtg ataggatcaa tgcatttggt tctgcaagtg tcaaagtatt gttggggaaa 41160 gcatgctgga aggaaagata gggatgctgg tgttctcagg gtggaaggct tacagttgta 41220 gtctggaagt ggtgatttta ttggcaatta taaggtcaac ggtatgacta tggaattgag 41280 tggctaaggt ctgttgaaga aaagattgtc ggaaatgcag gggtcaagga actggcctgt 41340 ggatgttgaa ctcactggca gtgatcaagg aatagtagtg gagtgaaagt agttaatgaa 41400 tcaggcacta agatctccaa gggatgaaag gatgcagttt ggagatgaca agataactgt 41460 agtaatcagg aatagcaggt tttgtagctc tgtctcatag gcctcagagg agatgggctt 41520 ttgaaggaca agagaaatga tgatgaataa attctaagca ggggaagtgt ttgggaaagc 41580 agggcaggct ttgtgctgtt gatggcaaat gatgtaccag acaggatgaa gttgagaatt 41640 tggaagttga tcactgatta gaaaggctta cattttattt tggccggggg tggcagctca 41700 tgcctgtaat cccagcactt tgggaggcca aggtgggcgg atcccttagg ccagaagttg 41760 gagaccagcc tggccaccat tgcgaaacac tgtctctact agaaatacaa aaaaaaaaaa 41820 aattagctgg tcgtggtggc acatgcctgt agtcccagct actccggggg ctagggaatg 41880 agaatagctt gaagccggga ggtggaggtt gcagtgagcc gagattgcgc cactgcattc 41940 cagcctgggt gacagagtga gactctgtct caaaaaaaaa aaaaaggaag ggcttacatt 42000 ttattttggt gctgactggg aatgaaggca atgagggatg actgttggag aaggctgtgc 42060 ttactaaaca gtattattaa gtagcagcat acatggtgtt atactgactt ctgattttgc 42120 aatagtacag acaggttcag attctcattt ccaccttctc cttctgccta ggtgaataac 42180 tgctgggtta tagtacagat gactgcagat catttggaat ttactttaaa tgtaaacagt 42240 aaaaatttga aagagaggga aagtgattga ggcaatttgg ggattgaata agaaggtctt 42300 tttgttggaa ttcatttaag gaaagaaaat gaaaatttga tccctaatat tatttaatga 42360 agtggctaaa tgaatatctc tgctttgtgg tttgaaaatt aatattgatt ttttttcccc 42420 ctagaggaag aaatcctact tagcgacatg aacaaacagt tgacttcaat ctctgaggaa 42480 gtgatggatc tggctaagca tcttcctcat gctttcagta aattggaaaa cccacggagg 42540 ttaaatatta cctttttttt ttttaactta aatcaattct gtttattttt ttatcacatt 42600 ttcctatatg tgaagaatac tattcattaa ggctgactca tagaaatttg cttgaataca 42660 cacacacaga ctgatgcata aatttgagaa atatctttcc agttgttgaa tagtgaatcc 42720 aaaggtttaa gccttttctg tctgctttgt aggatgtttt atgaaacaaa ggaatagaaa 42780 ttgtattcat attatacatt ttgaaattat atctatatta tattttttgt caaagcaaaa 42840 taaattatac attaaggaaa atatttaaga ttcaaagttg tcattttctt tctgttaatg 42900 agtatctttg atttaataac atttatagtt tggtcacttg aaatctatag tgaccaaaag 42960 caatgtcata tttagtagcc tcatttctgt tactatctga ttattactta agaattctac 43020 ttaattaata gattattaga acaaaaggca ttccaatttt agagattctt ttatggttaa 43080 agcactaggt aacttaaaaa atttggatca aatgttatac agattaatag accttggaat 43140 acaggggcta tgtctttttg gaatcagacc ttgtcctggc cttaattgca ggatgacttc 43200 cttattaaat ctctaaaagc aggaatgctc tggaacaatg aacaattaga atgtggtaat 43260 gtaattttgg gccaaaaaat actttgtaga aatgtgattc tcttacttgg aatagaaaga 43320 attctgactc gaaaaagtgc agttaatgta tgcttttctg ggtaagattt gtgatagatt 43380 ttgattgaga tttaaaacca tgatatataa atttagcttt tttgtcaaag taatttgcca 43440 ccctagaatt tgtgttggta atttttaatg caacttggac aatttctgaa agatgtaact 43500 ttcttttttt tgagacgagt ctcgctttgt tgcccaggct ggagtgcagt gacatgatct 43560 caggtcactg caagctccgc ctcccgggtt cacaccatta tcctgcctca gcctcccgag 43620 tagctgggac taccggcgcc cgccacccca cctggctaat ttttttttta tttttagtag 43680 agacggggtt tcaccgtgtt agccaggatc gtctcgatct ccggacctcg tgatctgccc 43740 gcctcagcct cccaaagtgc tgggattaca ggcgttagcc accgcgccca gcctgaaaga 43800 tgaactttaa aatggggaag gatactagta aagccatttc ttactcatgt atacattttt 43860 ccctccatga aattagagca gccacctttt acatgacttt tacatgcatt tcagattttt 43920 gtactagcaa ttaaaatatc tactggatgt aaatcacatg tgcttaatgc tttgcttcat 43980 aatatctgtt gaagtcaatt aaaatataga gacagatctt taaattgaac atgttttatt 44040 tgggaagcaa gaattaaatt tgaggcatat acacagactg ggtgtccttg gtatctctga 44100 agaacaaaga gaagtttgga ggttatagaa aaaggaaaat gtgacattgt ttttccagaa 44160 agttctttgg cactagtaaa ttttggggag ttggaagctc tgatgggtta gtgactgtgg 44220 tgggtaaaac tagtcttaga gtcacaacag gttgtttcag tatctattag ataaaacagg 44280 ttttaggtta caataggcag tttcagcagc taggcttgca gaaaattaca ttcttagagt 44340 aatgttatgt gccttgagtg cttttttccc cttggccctt gactctgatt tagttgggta 44400 tgacaagaat tatcaattta tataattact ttttacatat tgaagctgaa taggttttct 44460 taaaacttgg aaatgggaaa tactgggtct tgtgaagttt tagtgtgaaa acgataacta 44520 gtctcttatt tcatgctctt tgtaacaagt ctacagtaat acctaatgta tctagatgac 44580 acctcagaac caggagggaa caaaaaagac ctctgagcag tcaaaataat gctataagca 44640 tgtattccag cttactttcg gcatttctgt ggagtgcagg aggccacatt ttgttcatag 44700 atccagtttg acaagcttgg gtactgagtt aaagtgaaaa tggtgtaaat aagtaatcat 44760 attcacatga cagtaggtgg aagtgacagc tgacaatctg aaagagtgga caaaactata 44820 aaaattagaa ctaagaactc ttaaaataga acggtttgaa gtttgttaca gaagggagca 44880 gctttatgct tcagtggact ctgaaggtat tggcagtgta tagtactgct tagtcattga 44940 tttaaattcg gtatatatct cttctattgc tgtcatgtac ttgacattct gctgggtgct 45000 aaggctgtct gcaggctact aatatgcata ataacaatcc tgaaaaagaa ggaaaagtat 45060 actgtgcctt actgaagaag gcaggacagc cgttggtatt tgttagagta aatattagtt 45120 atcttacata aagcatgtta tattccctga tgtcagggcc tgataaatga gcccttacac 45180 tcttgatagt caatctgtgc cactgttgct gtgtttgtat gttacaccat ttcctgtcca 45240 tgtaacagtt aaactgtatc acatatctgt tcctactaaa ctatttgcat ataattttaa 45300 catttgagtg gctgtatata aagctaaaag ttctttataa gatttatagc atcttagaat 45360 gtttaaatta gataacatta gtgtgctttt agtttttgaa tttaattttg ctcttgattt 45420 tgtttgtgtt aatgtagact ttgtctacgt aagcttgagc ccaactttgg agtggtgttt 45480 tcagtgatgg aagtaactgg aaataactca tgaaaccact tagtactttt gatagtttat 45540 tcccatgaag gatcaaattt ttacttgagt cattaatata aaaatttaaa agacatgtca 45600 gattttatta agcatggatt ttaaatatat aaatattaga agacctaaac aaaatcgcta 45660 atgaaagagt aaaacatgtc cctgcctatc atactccctt cactttcact gatttctgct 45720 tttatgaagt actttaataa gctctacaac aaataaacaa gacattgtgc ctcattttac 45780 actctagcag tggttttcca ttccaactaa ctagattggg tttataatat agtcatttaa 45840 acttacttag ttaaaatgtt atacattagc aactgcaatt aaggagctaa gaaattcagc 45900 tcgtatttat ttatatgcat cttatccata gtttctcact tgttatattt gcctactgat 45960 ggcaaattga ttttttctgt tccaaaaatg tagtgttttg agatttttgg agatgcaaaa 46020 cagcatcatt ttcaaattag atcacaaaca atcttacttg ttgcagttga gactagtaat 46080 tgatcagtga ggtgaaaaaa ttaggcaaaa cggtatcatc aaaattttct ttcttttttt 46140 ttttgaaaca gagtattgct cttgtcgccc aggctggagt gcaatggcac gatctcagct 46200 cagctcactg gggcccctac ctacgggatt caagggattc tcctgcctca gcctcctgag 46260 tagctgagat tacaggcgca tgccaccaag cccagctaat ttttgtattt ttagtagaga 46320 cagggttttg ccatgttggc caggctggtc tggaacttca gacctcaagt gattcacctg 46380 cctcagcctc ccaaagtgct gggattacag gcatgaacca ccgtgcccgc cccaaatttt 46440 cttttaactt aaagtgttaa tgtttgtttg ttcccaatat ttttatatat gtcaaggctt 46500 tttcattata tacaggccag ctctttggag ttctgcatag tgtttcttgt ttaaaccaca 46560 cctataatgt accatctaca atttccaatt ctttaagaca gagtgaaaaa ttaagacacc 46620 tgaagcaatc tgagtgcgga gtcctaggca ttatgatttt ccttgacact tttagggttc 46680 ttttatcaca gtttatcaaa cacctttttt tttttaacaa aaaacaaatt tacaaaatct 46740 ttccatgtat tcaacttaga atttaatgaa atagggtttt tttttttttg gtggtcatgt 46800 atcatcaact ttctttacat ttaattaaat taatcaacaa aaaacatata gttgacataa 46860 acaaatttgg gaccaagcac tactgactct tagtaaacat acaagtcaac tgttggtgca 46920 gaagtgcctt gatgctagag agtagcctgc aagctgtaat tatatatggg cattagggaa 46980 tgaagaacag ccttaatact attgatcttt taagtgaagg tcagcttaga aagcttttac 47040 ttgttaaaaa gcttcacagt ttgtccttgt agttaatgca attgaagttg aattaatctt 47100 tcttaatttt ttttttaggg tttctatctt actaaaggat atttcagaaa atctatattc 47160 actgaggagg atgataattg ggtctactaa cattgagact gaactgaggc ccagcaataa 47220 tttaaactta ttatcctttg aagattcaac tactggggga gtacaacaga aacaaattag 47280 agaacatgaa gttttaattc acgttgaaga tgaaacatgg gacccaacac ttgatcattt 47340 agctaaacat gatggagaag atgtacttgg aaataaagtg gaacgaaaag aagatggatt 47400 tgaagatgga gtagaagaca acaaattgaa agagaatatg gaaagagctt gtttgatgtc 47460 gttagatatt acagaacatg aactccaaat tttggaacag cagtctcagg aagaatatct 47520 tagtgatatt gcttataaat ctactgaggt actaaataaa gaggaagcac atttttagtt 47580 attagtaggt tctggcagac tttattcccg taaagagaca gatagtaaat attttaggct 47640 ttgtgggaca tacagtctct gttgcagtaa ctcagttctg ttattgtagt gtgaaagcag 47700 ccacagacaa atgtaaacaa atgtgcctgt ctttcaataa aactttatct acaaatacag 47760 atagtgggcc acatttggct tgcgagctgt agtttgctgt tcctgactta gtatgatatg 47820 cagcattgtg tagtggaaag attttatagt atcaacagac atttgtagga gtttgctatt 47880 ttataatttc gtatgctttt ttcataatag atgtctctgc tttttgtgga ttctcttcat 47940 atctactagt gtttactctt ctgactttga tttttggggg tgtattttat ttctttatac 48000 agaatttttt tcttttttct ttcttttttt gagacaaggt tttgctgtgt caccccagct 48060 ggagtgcagt ggtgggatct tggccccctg cggtcttcaa ctcctgggct taagcgatcc 48120 tgtcacctca gcctccctag tagctgggac cacaggcctg caccactaca ctcagctaat 48180 ttttgtattt tttgtagaga tggggtttcg ctctgttgcc cagactggtc tccaactcct 48240 ggactcaagt gatccacctg ccttggcctc ccaaagtgtt ggaattatag gtgtgagtca 48300 ctgtgcctgg cccagaattt ctttacttgc tcatgtgaga gagtttctaa taaactcctg 48360 atgcttttgc ttgacactat agttttactg tcatctcaga gtcagatttt ttccttaatt 48420 tcttcattaa attgatttct taatttctca tttgttttgc attagtttac aaaattactt 48480 aagatgccta tattctctga aattttatat tttatttcac gataaataag tttaaaaaat 48540 tagatttgac catttaatta gagttatttc cccatcattt ttctaatggc aacaataatt 48600 ttagcatttg agcaattctc tgtattttgg taactattag taatcacttt tatcagtata 48660 aacatgcatt tcattttaaa atggttttca aaatattctc ataccaacca ttcataaaag 48720 atgttcccct tctgggaaat atcagttttt gctaacatct gcatttccct ttgattttct 48780 aggaatttct tattaggtat acactttaag tgatatgttt catataatat tataggatta 48840 tcaggatttc atgatttttt ttttttgaga tggaatctat ctctgtcgcc caagctggag 48900 tgccgtggcg cagtcttggc tcactacaac ctctgcctcc ccggttcaag tgattctcct 48960 acctcagcct cccgagtcac tgggattaca ggtgcccgcc accacacccg gctaattttt 49020 gtatttttag tagagaaagt gctgggatta caggtgtgag ccactgcacc tggccttgga 49080 tttcgtgatt tgactgacat cttttacacc aattattgcc atttttttat tgggtactaa 49140 ttattagtat tgctttcttt attcgttaaa taagaagtaa aagaactttt aaaaaataaa 49200 ataacttttt ttcctagtac aaagcttatt ttcaattttt tttattgctt aaattttgca 49260 ggttaattaa ggctgtactt ctttttccta cttcctgttt aaatatttgg cattttttga 49320 gggttttctt tctatggatt tttgtggggg atcccatctc gttggacact tggttcctgg 49380 agattgccaa attattgaaa agtttcctca tacccaaaca ttggcaatag actgaataaa 49440 taacatctct gacattattt ttcaattata tagagaatgc tttttgtaaa atactgattt 49500 atttaaagat attacaatca tagtagtttt ttgcaatctt ttttaaatca gtggatgtca 49560 aggaacaact attgttcttt gtacggcatt tttcaacatt gtgaagagtt cttatactca 49620 aaaagtttgg gagacacagt gtgacattgt ttaacctgag ttgaacttgt cattttgtat 49680 tcttgtttag agcagggatt ttattttgtc tctttatcta actttgtatt cctaactatt 49740 tctttctttc tctttggttc tttgtttctt tgttcattct tctctctctc ccttttttat 49800 ctatcatata aatatgtaaa tatatattat atatccatta gggaagagga agttgtctaa 49860 agatatctag tatataggag ctttgttctg cagaaaagag gatatgaagt caattatatt 49920 ggaaattaat gcttaatact ttttttaaag catttatctc ccaatgataa tgaaaacgat 49980 acgtcctatg taattgagag tgatgaagat ttagaaatgg agatgcttaa ggtatgttta 50040 caattataaa aatattactt caagttcttt ccaaaggaca tttaattaag taaaatatta 50100 actaattcta aactaggttc taccacaatg aaattgctac taattatgta acattagatt 50160 tcacattttc caattcatgt ttctttcatg tagtctataa ataatgggtt agaggtaatt 50220 tactaatttt aaatgtgctt tccttgttcc ttcttatttt ttattttgaa gacagggtct 50280 cactctatca cccaggctgg agtgcagttg ctccatctcg gctcactgca accttcacct 50340 cctgggctca agtgatcctc ctgcataagc ctcccgagta gctgggatta tgggcgtgca 50400 ccaccatgcc cggctaattt ttatagtttt agtagagaca gggtctcacc atgttgtcct 50460 tgctggtctc gaactcttta cctcaagtaa tccacccgcc ttggcctccc aaagtgctgg 50520 gattacaggt gtgagccacc acacctggcc ttggatttca tgatttgact gacatctttt 50580 acacaaatta ttgccatttt tttattgggt accaattatt agtattgttt tctttattcg 50640 ttaaataaga agtaaaataa ctttttttta aaaaaagaac ttttttccta gtaaaaagct 50700 tattttcaat ttttttattg cttaaatttt gcaggttaat taaggctgtg cttccttttc 50760 ctactttctg tttaaatgtt tggcattttt tgagggtttt ctttctatgg atttttgtgg 50820 gggatcccat cttgttggac acttggttcc tggagattgc caaattattg aaaagtttcc 50880 tcatacccaa acattggcag tagactgaat aaataacatc tctgacacta tttttcaatt 50940 atatagagaa tgctatttgt aaaatactga tttatttaaa gatattacag tcagtagttt 51000 tttgcaatct ttttaaaatc agtggatgtc aaaaacagct attgttcttt gtacagcatt 51060 tttcaacatt gtgaagagtt cttatactca aaaagtttgg gagacacagt ttgatattgt 51120 ttaacctgag ttgaacttgt cattttgtat tcttgtttag agcagggatt ttattttgtc 51180 tctttatcta actttgtatt cctatttctt tctttctctt tggttctttg tttctttgtt 51240 cattcttctc tctctccctt ttttatctat catataaata tgtaaatata tattatatat 51300 ccattaggga agaggaagct gtctaaagat atctagtata taggagcttt gttctgcaga 51360 aaagaggata tgaagtcaat tatattggaa attaatgctt aatacttttt tttaaagcat 51420 ttatctccca atgataatga aaacgatacg tcctatgtaa ttgagagtga tgaagattta 51480 gaaatggaga tgcttaaggt atgtttacaa ttataaaaac attacttcaa gttctttcca 51540 aaggacattt aattaagtaa aatattaact aattctaaac caggttccac cacaatgaaa 51600 ttgctactaa ttatgtaaca ttagatttca cattttccaa ttcatgtttc ttttatgtag 51660 tctatgaata atgggttaga ggtaatatac taattttaat tgtgctttct ttgttccttc 51720 tttttttttt ttttattttg agacagggtc tcactctgtc acccaggctg gggtgtagtg 51780 gtgccatctt ggctcactgc aaccttcacc tccagggctg aagtgattct cctgcatgag 51840 cctcctgagt agctgggatt acaggcgtgt gccaccatac ccggcttatt tttgtatttt 51900 ttgtagagat ggggtttcac catgttgccc aggatggtct taaactcctg ggctcaagtg 51960 atctactggc ctcagcctcc cagcgtgctg gggattgcag gtgtgagccg ccgcatccag 52020 ccctgtgttc cttcttgtgt tactttcttg taattttttc ctggaatatg ggtagtgatt 52080 tggctctcca gtattgaaat tgagtttcct ttcttccaat tcatgtgtat ccatttttat 52140 ttggaagttt tgtttttata cattcaataa tcatctttac tttctttggt attatttact 52200 atggatattt tatattatat aattttcaaa tggattaaat ggttcagttt tactcttatt 52260 attgagattg aaaatactag tttataattt atatattttc tattccttta cctctaattt 52320 ctttgtcagg tgttactaac caaagatgta taataagaaa agccaatgta gctaaattaa 52380 gtaaaaaatg aagaaaaaca cagaagttcc ccattatgca tttttttatt cctaatcttt 52440 aggttgatga gattttttta tttttatgaa atgagattaa tttattgact tttttagttt 52500 tgaggccaag taatgagtag tgagtaagaa tgtatattct agggccaggc atggtggctc 52560 actcatgtaa tctcagcact ttgggaggcc gaggcaggag gatcacttca ttccaggagt 52620 ttgagaccaa cctgggcaac atggcaaaac cctctctctc cagaaaaata caagaattgg 52680 ctgggtgtgg tggcatgtgc ctttagtccc agctacttgg gaggctgagg tgggaggatc 52740 acctggggag cctggggagg ttgaggctgc agttagccat gaccatgcca ctgcactcta 52800 gcctgggtga cagagtgaga ccctgtctca attaaaaaat taaaaaaaaa aaagtagatt 52860 gtgaattcag atgtaggttt gtatcccagc ttttccagtt agtatctgtg tgactttggg 52920 gaagtttctt agcatctttg atactcggtt aacagttgta attattattt aaggtattgc 52980 ttgagaagag cttagtatag agcctgacat ttagtaagtg tttaatacat attagctaac 53040 agtaaaacta gaacataaat actgaattgt attttgttat taattatcca tttctctgag 53100 aagtactgtt ccaatagtac atttatagga aacttgtgga cgtctacaaa cgtatacatt 53160 aaatctctta gaaggcaacc tggatgccca tattagagaa ctctatttta aacatgcatt 53220 ctaagtatgt ttgtggactt gaataaaata aaacaaacag aaacacttct ttcttctgcc 53280 ttcaggcttg aaatgaacat actttttttt aaaaaaaaac cttcaaaatg aaaatattaa 53340 ataaaagatt taataaaaag agaaagtaaa aactgtagtt taataaagtc ttcctgtctc 53400 ttcatagtta aaaaatgtta tagatgaaac aattttgaaa tattcttgaa atagataatc 53460 tttatttagg ggagaatgtc agatactgtc aagccaaaat aaaaacaaat aactttattt 53520 catgtttgta aaattccttt tctaaaatga tttgaatctt ttgttgtttt gacaattcca 53580 aaacacattt attgtttgct catagtttca gccttattca gaaagaatgc gactgacaca 53640 tgatatagag aaacttgttc caaaaataac attaaaatcc acgtttacta cttgagaatc 53700 gaaaatattg aggtgcaata aagaataaaa tgttttaaat tatccaaatt taaaatttat 53760 gatagctttc cccaggggca gtttattata tgctattaat gagccttgtt tatgctggaa 53820 atgttccatc tttggccttg cgccttagaa accattcatg agcacatatt taaaccggag 53880 cacacatgtt cttttgtagt atggcttgca catctgccag ctttcgacaa aattgtaggc 53940 cctgttaata atagtccttt tgtgtttggt gaaaaagata cgacactgtc agtggttttg 54000 cttttaagat ttcttttaaa ctttcagtct ttagaaaacc tcaatagtgg cacggtagaa 54060 ccaactcatt ctaaatgctt aaaaatggaa agaaatctgg gtcttcctac taaagaagaa 54120 gaagaagatg atgaaaatga agctaatgaa ggggaagaag atgatgataa gggtaagcac 54180 tgaagtatgt ttgaaatgac tcacctgtga tacctaccac tgactttaac ttaggatcca 54240 gttttggatg gtttggaggt cagggacttt gtggcatata gttaattatt ggatccttat 54300 aagcttttgt ctccttagtg cttttgtctc cataaagcac aatcttacta cttagaaaaa 54360 tagagtaata gcattatgat gataaaaata tctttccctt tgtttttttg tatttctcca 54420 aatcattata gctctcattt agaattatta aagctgagaa ctctaacaat gaacttttat 54480 tgtttagtgg ttaattatct tgattctttg ttttgccctt tcttggccac tcaggaatct 54540 ttcaagctca ctgtggacag ggaaagtgac ttgggtagag ctaacataac ttcattgtgc 54600 tgtgcagtta gaattttgac caaagatgtg ggtaactaac ttttcctaac taaatgacat 54660 ttaggtaact aaactaaacg agattttcgt aactaaattt tggtgtaact acatttagct 54720 ttaggtaact aaaacgaaga ttttatttta tctgtggatt tttttagtgc gggactaatg 54780 taatttctga ttaccattaa ttgaaggttg gttatattat aacatttgga ttggtatatt 54840 gcttgccatg gtttgttcta aatgttagcc tttagaagta ttcctgattc taaaacatca 54900 gtttttttta atagtcctgg caaagtgtga atcacaacaa aattctaata cttaaaagta 54960 atccaagtgt cacagatggt acccagaaga ccagtttgta ttggaattaa aaaatagaaa 55020 acattaaccc atggtagctg tcactgtatt ctttcaaaga agccaatgaa ataaactgtt 55080 ttctccctct atgtggtgtt tttctacttg aacataaatg cacattttat tttatttcca 55140 gactttttgt ggccagcacc caatgaagag caagttactt gcctcaagat gtactttggc 55200 cattccagtt ttaaaccgtg agtataatct catttaatca aatcacatat ttagtattct 55260 ctttaaaaca agggaaaagg caaataacct gtctgcttaa cagcaacagc acaacttcac 55320 tatagttata catgccacac tgtattttct gtgtgactac aaaattattt caaagtgata 55380 tttatataaa attcatttct gcaaattgtt tttataagtg aggaaaaatg gttttccttt 55440 aactgagcag ttctgagtag aaactagttt aaagatactt ataaataaat gttaatttaa 55500 tactgacttg tttttcatta aacgagtgtc tatgtgcctg ttttgtgtat attacccaga 55560 acatgcagat gtactagaag ttcttaatac aacaatttga ggaatagtga taatcttatc 55620 tattttaatg tactcaaaat ttgtttacat ctaacaggca catttttgtg aggattaaat 55680 gagatgaata agaatgagat gaacaagtaa atgtgaataa aactaataag cctgtgaaaa 55740 tctagactgg atttttccta ttctgagaat ttaaaatata atccactgaa gtatttcttt 55800 ccttttttct tttgatctta aacatttttt atttatgtct tacatacaga aaagtgcaca 55860 tgttgtagag atcaatgaat tgtcataaac tgggcaccct gtggccagca cttagttaag 55920 aataggtcag taacagcatg ccagaagacc acctctccaa ttgatttttc ccatgatatt 55980 ttattaagaa aattttctaa gatgtagtaa agttgaaaga acttttttct gtgcatgtct 56040 gtattcccac cacctaaatt caactatcat tactatactt gctttatcac atatccatcc 56100 attcatatgt ctctatccat ccattcattc attccagttt taaaatgcat ctcagggtca 56160 atcgaggaca ccattacact tccacctaag tatttcagca tgtaaattat taacgagtta 56220 aatatttact taacagtttt ttctttggtg taaaatttgc acgtaaggaa atataaaact 56280 ttaagtgtac atttgcaaat tttaaatata catgtgcata cccatgtaac ccaaattctt 56340 atcaagagat attattatca tcaccacaca gagttccctt atttcccttt tcagtcagtc 56400 cttgtccctg agcatttctc ttattatttt aaagtattga ttcttttgga tatctagtat 56460 gaagcttaga atctgttttt tactttagat gtatgtagtg aaatttaata tatataccaa 56520 atggtagttg ttagttagct tgaatgggac attggtcaaa tggcattgtt tgttttaaag 56580 ttccaggttt gtgcatttat gtatgaagtt tgaaaataaa ttctatgaga ggaaatgaaa 56640 aattgaatgg attttaattt gtaccttggg tttcttatta ataaaacaaa atagcttttt 56700 gcttttcacc ttcaagagtt cagtggaaag tgattcattc agtattagaa gaaagaagag 56760 ataatgttgc tgtcatggca actggtaagt tgtacttaag caaaacctaa tcctttaaaa 56820 aaataaaaca taaagagttt gaaatgctta atctttcatt aaactctcaa aatacaaatg 56880 caactacaaa tgatgtaaac tatagaagag agtgaacaaa gaacagatgc tcagatttat 56940 gtatcaatta gcttttagga agatagcata ctagtattga ccattcatct gtataagtac 57000 attgtaaaaa gaaatgaaag catcaaaggt ttatttttat ttctatattt ttttcatttt 57060 atttttatat ttttttcatt tcaaggatat ggaaagagtt tgtgcttcca gtatccacct 57120 gtttatgtag gcaagattgg ccttgttatc tctcccctta tttctctgat ggaagaccaa 57180 gtgctacagc ttaagtaagt catgttatca ttgccacaat atcaccctct ttttttcttc 57240 tgtgggtgaa acatctgatc catcatgcat gttaaaatct agttcacaat aacacatttc 57300 tgcaggtatt gctttatctt tattggtaat aaatgaccct ttagtggaag agcttacctt 57360 ctttcttgtg ttctctgtaa ttcaaagcta ccaggtggcc ctgataaaat ttttttaaaa 57420 aacattatta ctttatgctg gtttacattg aatatctcaa aattcttttc tctttttgtt 57480 acccttgctt tttagcttga taagaagtgt atacatggaa gtatattttt tatctatgaa 57540 acacttttca gcttcttcaa cctgagcttg caatctgttt taaattgata cataatatct 57600 ttacatattc atggggtact gtagtatttt gatacactca tatcaaatac acttgatcaa 57660 atcagggcat ttgttcatca acttgaacat ttatcatttc tttgtgctgg gaacatttct 57720 aatcttttct ttgagttatt ttgaaataca cagtgttgtt gttaactata gttaccctac 57780 tgttggttaa tgagtacaaa catacagtta gaaggaatag gttctagcaa cctattcctt 57840 taccccctgt catcccctgc tgccctgagc ttgcagtctc tttcaaagac ccaccttaaa 57900 aacttgcatt ctgataaggc ccttgaagga atttgcttat caagttagta agtgacaaaa 57960 aagaaaattg caaagaacag gaatataaat tattatattt ctttattctt tctcacttaa 58020 gagtgaaatt gatatgtgta atgtgtacat ggtgccagaa tatttgtttt tcttcttata 58080 gaatgtccaa catcccagct tgcttccttg gatcagcaca gtcagaaaat gttctaacag 58140 atattaaatt gtgagtaatt tttttccctc aacttttatt ttggatttat gggggtgcat 58200 atgcaagttt gttacgtggg tgaattacat gttgctgagg aagttgtgag taatttatgt 58260 catttctaat catgtggtca gatgtctgtg gtatatgaga gaattttgta tacaaacaaa 58320 ttttactaaa tgcatgaaaa aaaaagtcca tgattttaaa atgcactttc ttttgtacct 58380 ttgcaggact gttacttttt aaatccttca aacttgaaga aatctgttat tctcggttct 58440 tgggctataa gattagcatt gtactcatag aattataaaa attttggttt tggaagagaa 58500 gttggagaat ataaagattt gtctcatttt atagatgaga aaactgaggc tcagagacaa 58560 gtaatttgcc caaaatcaca caatgactgg ctgagcaggg actggattct aggtctcttg 58620 cccaaccaat tctatcatga tgtaattcct aaggagaatg tcatctcaga tacacataca 58680 cacacccatt ttgtgtgtgt gtgtgtgtgt gtatatgtac acacacacac aaacatatgt 58740 acacttatat atacatacac acacatatat taatatatat gcatatatat gcatgttcta 58800 attcagaaca ttttcatcac tcccaaaaga acacccctgc ccattaagca gttgctttct 58860 ttacgtatat attagtatat acatacacac gagatacaca tatatttact gagttttgat 58920 aaatgcatac aaagatgtaa accaaacctc taacaagata cagaatatca ctgacactct 58980 agaaagtttc ttcatgtccc tccccagtct gtccttccat cctccatcct aggcaagcca 59040 ctgctccgat tttctctacc atagtttggt agaatgccat ataaatgcag tcacacaata 59100 ttaactcttt tgtgtaagac ttctttcatt tgctgtaatg tttctgagat tctttcatgc 59160 tgttgcatgt atcagtagtt ttttgttttg ttttgttttg tttttgtttt ttcagagtca 59220 gggtctcctt ctgtcaccca ggctagagta cagtggcgca atcatagctt actgcagcct 59280 ctaactactg ggctcaagct atcctcctgc ctctcaagta ggctaggctg caggtatgtt 59340 ccaccatgcc tggctaatta ttaaattttt tgtagagaca ggatcttgct tggttgccca 59400 ggctggtctt gaactcctgg cgtcaggatt gtttccagtt ttggattatt acaaataaag 59460 ctgagacaca tataagtctt tgtatggaca tatggtttca ttttattgat acatgtcaag 59520 gagtgggatg actggatcgt gtggtggata tatgtttaac tttctttttt ctgagataaa 59580 attagaaggc gatcctcctg ccttggcttt ccaaagtgcc gggattacag gcgtgaacca 59640 ccgcacctga tgcagttgtt gttgttgttg ttgttttaat atctgattat tattttattg 59700 tatttcattg aatatagcac agtttgtttt tacattttct tattgataga cacctaggct 59760 atttttctgg ttttggactg ttactaataa agctgctata cacatcctta taaaaatctt 59820 ttttgtgaac atgttttctt tttttctaag cattttaaat cacctttatt gaggtgtaat 59880 tgacttacaa taaattttat atgctgagaa tgtataattt gataagtttt gacacaggta 59940 tgcactcatg aaaccatcat cacaatccag ataatgaaca tattcatcac ccacaaagtt 60000 tacctttttg ttttaacccc agtcaccggg taactgctga gctccttcct gttactgtag 60060 actagtttgc attttctaaa cttatataca tggagtcatt catattttat gtgctctttt 60120 ttgtctgatt taaataatgc agtataatta ttttgagatt cattcatgtt attacagtga 60180 ttaatagttc attcctctta ttgttaagtg gattacattt tatggatatc caacaagttg 60240 tttatccatt cacctgatag acatttggat cgtttccagt tttgggttat tacaaataaa 60300 actgctatga acattcgtat gtaagtcttt gtatggacat atgttttcat tttattatat 60360 atgacggagc ggaatgactg gaacatgtga tgcatatatg tttaactttc ttttttctaa 60420 ttgagataaa attcacagaa cataactttt accattttaa tcattactaa agtccagtgg 60480 gttttggtat agtaataata tataaccatc ataattaatt ccagaacatt ttcctaactc 60540 ccaaaagaaa ttccataccc attaaggagt cattccctat tttccctttt cttttctttc 60600 tttttttttt tttttgagtc agggtctccc tctgtctccc gggctggagt gcacttgcat 60660 gatcttggtt cactgcatcc ttgatttcct gggctcaatt gatcctccca cctcagtctc 60720 ctgagtagct gggactgtag gcatatgtta ccatacctgg ctaatttgtt ttattttgag 60780 tggagatgag attttgctat gttgcccagg ttgctctcaa actcctgggc tcaagtaatt 60840 gtcccacctc agccttccaa aatgctggga ttacaggcgt gagccactct gcccggccta 60900 ttatctctgt tctgcccact tccaaccact aatctacttt ctgtctctat gatttgccta 60960 ttctggatgt ttctataaat taacttatac attatatggc cttttgtgtc tggcatcttc 61020 cacttagcat agtgatatca gtacttcatt cggtcttttt ttatgactga ataatattcc 61080 atagtatggg catacacatt ttaaaaattc attcatcagt gatggacatt tgggttgttt 61140 cctttttggc tgttatgaat aatgatgctg tgaacatttg tgtaccaatt tttttatgaa 61200 catacatttt caacgctttt gcatatatgc ctaagagtgg aattgctggg ctatatgcta 61260 attttttaag aaactatgaa gcttttgaga gtgattgtat catgggatat tcccaccagc 61320 agtgtatgag aggtccagtt cctccccatc cttgctatca cttagtctgg ctgatcttta 61380 acttaagcca ttctaatagt atctcattgt atttttagtt tgcttttccc taatgactaa 61440 ttatattgag catttttcat acacttattg gccatctgta tatcttcttt gagggagtat 61500 ctgttcaaat cttttgccta ttttttctta gtgagttttg atagtcattt ctatattctg 61560 aatataaatt atttatttga tatatgcttt gcaaacattt tctcctagtt tatggctttt 61620 catactttcc acacagttct tttgaagagc agcagttttt cattttgata aagtccagtt 61680 tgtcgattcg ttcttttagg gattttgctt ttagtgtttt gacccaaggt cacaaagatt 61740 tgcttttatg ttttctccta aaagttttat agttttaagt tttacattta gatttacgat 61800 tcatttttag taaatgttgt ctattgtatg aggtattgat tacagtttat gtatttttca 61860 catattgttc cagctccatt ttttaaaaag actatgcttt tacactgaat tgactttgta 61920 cctttgtcaa aaataaattg actacatata tgtgggtcta ttgctgcact ctctattctg 61980 tgttctgtgg atctatttgt ctgtcttgat tggtgtcttg attactgtag ctttataata 62040 aacctggaaa tcaggtagcg caaggcctct tgctttgctc ttttctttca aagttgttct 62100 ggctattcta tgtcctttgt atttctgtga gcatgtcagc atcacctttt caacccatat 62160 gcctgctggg attttgaatg agtttacctt gaatctagat atcgaaacaa ttagctgtct 62220 tgatagttat tgtcaccgtt ttataccgaa gaaactaggc atactaaagt aacttggcta 62280 acatcactta ccttgtaaga agtagaactg ggctgtttga catcagagct tattctttat 62340 accatttcct atgttaatta gaatacaata ttaatttcat aaaggtaaag gcatatctgt 62400 tttgttccta tttgattcct tgtgaaagca caatgcctag cgcacaatag acacttaaac 62460 ttatctgttg aatggacagg tgaatgcttt taaagtcttt ccatatagaa aattaagttt 62520 cattacattt gacttgatct aggttttcat ttcatagaat ggagagcaga ctctgtaaat 62580 attttgcccc agacctagct ttattacaaa cattgtctta attaggattc tgtctaccca 62640 gaatagaaat taactcaagc tagcatgagt gtatattgaa atttatatta aggataaagg 62700 aatgtctcat agatcccact caaaagaaat tagccagccc ttaggaagag actggaattg 62760 ggtttggaaa atacaatagg tctttctttt tatctgtagt ctttagtgag tcttcctcat 62820 ttttctctct gaagagataa gcattctctg catatatata gcattctttt agattttcgt 62880 gacataaagt attatttaaa ctttcataag gtatcttgat tttaagttgt aattccttga 62940 gatgattgtt ttctttattg ttaatatgtt tcccttcctg tttttttttt tttctttttt 63000 cttttgtttg tttttacaga ggtaaatacc ggattgtata cgtaactcca gaatactgtt 63060 caggtaacat gggcctgctc cagcaacttg aggctgatat tggtaagtga taaagaaaga 63120 tctctgtaaa tacttactga gttaatattt aaagttaaac ctatggatgg acactggatt 63180 tcacttctgt taaagtttat ttcaaacatt acttcctcca ggaaatctct gactctctaa 63240 cttgctgttt cacctatctt atcccatgat actctataat tccttttgct atagaaatta 63300 ggctctgtta tcataattac ctgtttatat atctgttttc ttctgctagg ctataaactt 63360 ttcaagggaa aaatatcact ttttaaaatt tatgtttccc cagtgcagtg cttggcatat 63420 aggcacttaa acatattgtt gaatgaatgt tgaatcctag gttctgtgaa attttaattt 63480 acttgttttt catgttctgt atctaaatta agtcagtgta gtggttttgt accctctttg 63540 ttcataagaa tcacttttca aactttaaaa aaaatgtagg taaccaacac ccaactctga 63600 aaattctgat ttaacaggcc tgggttggca cctggcattg gtggtttctc acaggtgatt 63660 ctgatatata gcccgggttg gaaaccacag tacctttgat tagttgccac tagtgagtat 63720 gatttattac aaaaaccaaa aacttagata agtcacagtt tatttcctag aacgtgtaaa 63780 tatagaatta gtcaaaagct gatagcactt tttttgtact taaaaatatt ttaagcctca 63840 gtatagtgag acctcatctc tacaaataat tttttaaaaa attggccgag cctggtggtg 63900 catgcccata gtccaagcta cttgggaggc tgaggtagga ggattgtttg agcctgggag 63960 atgaaggctg cggtgagcca agatcatgct actgcactcc atcctgggca acagagcgag 64020 accatgcctc aaaaaaaatt tttttttctt cttggtggtt aggcttaact atccaagaat 64080 tgcaatcatg gcttctattg caaatgcccc tatttcccac cttcagttgg cctaaccaaa 64140 tttaattttt caatatcata tgatcttttt gtataattat gtattcaaat aattccagat 64200 aggttaggtt ttcgaattgc aacgtctcat ttaatggtta ctttcatata actgtaggaa 64260 agcatttgat aatttttcca acaatgtaat gaaaacaaac ttgtatcttt tttattatgt 64320 gttaaaacca acaaaagaat gagggcagca attaacattt cattaaatat attagcaatg 64380 agtacattta tgagctctta aactccctta ttgacatact gtattttttg cctttaatgg 64440 acaatgaatt tgatatgttt cctaataggt tgtatgaagt tattgtgaat atttcacttt 64500 ggattaagaa taactaccct atatataaat ttcatggttg tattgcaaaa gctggggtct 64560 atgtccatag tggtttgggt acgtttttac tatttgcttt gtttctgtga tagtgttaaa 64620 tgaataataa gcttaagtat ttaagcaaat acttaatact tctgacaagt agttagaact 64680 ctctattttt gtttttttgt aatggatgag ttatggacac tgcaattatt agagcagcgt 64740 actttgctta tgatggatga aaatgttctc tggttgactc agtgttgaat aaaaagggat 64800 acatgaaata aaaattattt ttgaaatatt ttcctttgcc ttttgttgcg ggaaattgta 64860 caatgcttgc aaaaatgaat atacgcagga tattatttgt acagcagtct gacatttagc 64920 taatcagatt cctcattttt aggtaaatgt taaattactt aagtagtctg gatttttaac 64980 agaaacagca aacatagttt tatagggagg ctccttacca accagacttt taacttaagt 65040 gaatgttggc aaaagcttgt ctaaactgat ttccagggat aaggtttagc tccattaaaa 65100 gctagtttgt caaacctgta actaaagctt tttaaaaaat gaaagtttta aaagagacca 65160 tcattctgtt ttaacctatt taatttaaaa tctgggctga agtaggagta ttgcttgaac 65220 ccaggagttc gagaccagcc tgggcaacac agtgagaccc catctctgaa aaaaaaaaat 65280 gagctgagca tggtacctgt tacagtgcta gttatgaaag aaagaaagag agagagagag 65340 aaggaaggaa gggagaaagg aaggaagggg ctgggagtgg tggctcacac ctgtaatccc 65400 agcactttgg gaggccgagg cgggtggatc atgaggtcag gagatcgaga ccatcctggc 65460 gaacatggtg aaaccctgtc tctactaaaa atacaaaaag aaaaaattag ccgggcatgg 65520 tggtgggtgc ctgtagtccc agctactggg gagggtaagg caggagaatg gcatgaaccc 65580 gggaggcaga gcttgcagtg agccgagatt gcgccactgc actttagcct aagaaaagga 65640 aggaaggaag gaaggaagga aggaaggaaa aatcagtcac tcactcaggt ttagtttcaa 65700 aagccaaaac agtgataata ttgaattttt tccagccact cagtagtacc cagagaattt 65760 tgatacaaat aactgacttt gaccccatgt ttagtaggtt ttttttttgt ttgtttgttt 65820 gttttttttt tttgtctttc ttctccacac tctcttagga ctgttgtagc ttgtaatgtt 65880 agtgaattgt aattgtttat ttgcatgtct gtctcctctt ttagaattgt gaactcctca 65940 ggtcatggat tgtattttat tagtcttttt attcctagaa aagtgtttgg ataataatag 66000 atatttatta accataatag gagtagtagc atttttgtgt gtgtgtgcca ggccctattt 66060 tagcatttta tgtgaatgat ataatttaat ttttagagca tctagaaaat gttaggtacc 66120 attattatcc acattttact tgtgagagga ctgagacttg gaaagcttaa gtaacttgct 66180 taaggtaata cacatggcag atggtggagc caggttctgc atctgggcag tctgacttta 66240 gagcttttta atcatcctcc tcctagtgtc cgaacattat taatgctcag agaagtatca 66300 aagaatgatg atactcattg agggaaaaaa ttattcttaa gtatcaattt gttaattgag 66360 gacaaaagca ctactgttac tactgtgaaa aatctgaaaa cattgtcacg gatgatttta 66420 caataacatc cttttctgac atgcattaca acacactatt gattccgttt caatgtttgt 66480 gtctggtatg ggggcggagt agagaggcta ctacaggaag aaagaacaaa taacatttct 66540 tcttactact ttgtgcatca tgtgatttag ctcctcccat accattttac attagaaaat 66600 gtggctgtcc tcctgtgctc tagtactggc atttcagagg actctttgca atatgatatg 66660 tgatcaatca tggatggcga tgcagttaat ttcagtagaa atttgctgac tctttttatc 66720 tcttttaata gctaatgcat gagataaaat tgaaggtatt accaaggaga aatgcaggtg 66780 gatagttttg gaggcaaagt cacagtaagc aattcatctc tccaaggaat agtgatgaaa 66840 gctgagatcc aataaatgtc ttgtttggat taatacataa atatttcctt ttaaaattct 66900 taaggctttt attcatatat ctcccctctc cctatttcca ataatgattt ttggtgttaa 66960 tatgatgata tttatgcttc tgtttttata ggaaccaaat actttgattt ggttatttat 67020 tctcctttgg agatgtagat gagtttattt tttcctttcg agctttatct tttcctttat 67080 gtgtttttct ttttttacag gtatcacgct cattgctgtg gatgaggctc actgtatttc 67140 tgagtggggg catgatttta gggattcatt caggaagttg ggctccctaa agacagcact 67200 gccaatggta agctttgcca agtctgatgt cccgaaatta cattcttaat aaggagagca 67260 ttcaggattg gggagtggta aagaagctga agacttcact ataaaagagc aaatggataa 67320 tgtaaaaaga gaactatttt tttaaaaatg ctaaagttgg tatataatct attgaggaat 67380 ataatagaac aaggcttgac aaaccttttc tgaaaggacc agataataaa tatttcaagc 67440 tttataggcc acatgtagtc tgtatcacat attcctctct ctgttttttc ttttagtaac 67500 cctttaaaaa tataaagagt tacatttttc actggtgggc cataacaaaa caggctgtgg 67560 gccatatttg tccgaatgtc ttctcagtga tctttcatcc gtatgtcctt ttactctagg 67620 atgctgtgaa atcctggtta ccccttcttg tatcacattg aaaacctaaa gtttgaacta 67680 ttctatagaa attttattaa agcttttggt attagaattt ccctttcttc cctaattata 67740 aaaaatagca aattttggcc gggcatggtg gctcacgcct gtagtcccag cactttggga 67800 ggccgaggtg ggtggatcac ctgaggtcag gagttcgaga ccagcctggt caacatggtg 67860 aaaccctgtc tctactaaaa atacaacaat tagctgggcg tggtggcagg tgcctgtaat 67920 cccagctact tgggaggctg aggcagggga attgcttgaa ctcgggaggt ggaggttgca 67980 gtgagccgag attgtgccat tccactccag cctgggcaac aagagcgaaa ctctgtctca 68040 aaaaaaaaaa aaaaaaaaaa aaaagtgaat ttttacatga atattctaca tgattggcat 68100 atttacatga atggtttaaa aacccacaat aatagcactg ttttattttt tattttgaaa 68160 attgtagatt cacaagaagt tgtaaaaaaa aaaataccta tatagaggtc ctatgtacct 68220 ttcatccagt ttcctgaaca gtaacatctt gtgtgactat agtacaatat caaaactagg 68280 aatatgacat ttgtacagta tctagagttt attcctattt ctctagtttt gtaagtactc 68340 ttttgtatgg catgtgtatt gttctataca gtttaatctc atgtacattt gtgtaactac 68400 cactgcagtc aggatgccaa atgttccctt accacaaagc tccctggagc tgttcttccc 68460 acccctggcc ctagccactg gcaaccacaa atctggtctc tatctctaaa atattatttc 68520 aagaatgtta tatacatgga atcatgcaat ttgtcacctt ttggaattag tttttttcac 68580 tcaacataac taccttgaga tctatccaag ttgtttgtgg tcatgtgttg cctaacaaca 68640 gggatatgtt ctgagaaatg tgttcttagg acattttgtg gttgtctgaa catggactta 68700 cacaaaccta catgataaag cttactgcac acctaggcta tatgatagag cctattgctc 68760 ctaggctgta aacctgtaca gatgttactg taatgaatat tgcaggcaat tgtaatacaa 68820 tggtaagtat ttgtgtatct aaacttatct aatgtagaaa agacacagta aaaatacagt 68880 ataaaagata aaagatggta tacctgtata gggtgcttcc tgtgaatgga gcttgtagga 68940 ctggaagttg ctctgagtga gtgagggagt ggcgagtgaa tgtaaaggcc taggacatta 69000 ctgtacacta ctgtagactt tatacatatt gtacacttag gcgacactaa atttttaaaa 69060 ttttctttaa aaattttctt tcttcaataa taaattaatc tcagtttact gtaactttaa 69120 ttcataaacc taaaacattt tttgactttg gactcttgta ataattctta gattaaaaca 69180 tgaacacatt gtacagctgt acaaaaattt tttcttcctt gattaatgca ttccataagg 69240 ctttatttta aaattttatt atttttattt ttaaaacttt tttgttaaaa actaaaatac 69300 acacatatca gactagacct acacagggtc aggatcatca atgttgctgt cttccacctc 69360 cacgtcttat cccactggaa gttctttagg ggcagtaaca ctcatggagc tgtcatctgt 69420 gataacaatg ccttctccta gatacctcct gaaggacctg cctgaggctg tttttcagtt 69480 aactttaaaa aatgaatacg taggaggagt atactctaaa ataatggaaa agggtatagg 69540 taaatacgta aaccagtaac atacttgttt attattcatc aagttatata ctgtatataa 69600 ttgtatgtgc tatacttttt aatgcctggt agtgcagtag gtttattgac agcagcatca 69660 ccacaaacgt gagcagtgcc ttgtgctaag acattatgct ggctatgaca tcacttggtg 69720 ataggaattt ttcagctcca ttataatctt atgggaccac tgttccacat gtgctctgtc 69780 attgacagaa atgccgttaa gtaccacatg actatttttc ggtggtctgt tcctttttat 69840 tattacagag tattccacag tatggttgta ccacagttta actgatcacc tgttgaagaa 69900 cttttgggtt gttttccagt ttttgactat tatgaataaa gatgctatga acatttgttc 69960 atatctcaaa ggttctttat ttttttttat ttatttttct ttttttgaga cagtctggtt 70020 ctgtcaccct ggctggaatg cagtggcgcg atctcggctc gctgcaagct ccgcctcctg 70080 ggttcacgcc attctcctgc ctcagcctcc cgagtagctg agactacagg cgcccgccac 70140 tgtgcccggc taattttttg tatttttagt agaggcagcg tttcaccgtg ttagccagga 70200 tggtctcgat ctcctgacct cgtgatccac ctgcctcggc ctcccaaagt gctgggatta 70260 caggcgtgag ccactgcgcc cggccttcag agattcttta atgggtgaat ggttaaacaa 70320 cctgaaaata taaaagtttt catttctctg ggataaatgt ccaggagtgt atttttagtt 70380 tttaaggaat tgtcacaaac ctgttttcca aagtggctgt agcattctac attcctgtca 70440 gcagtgtgtg aatgatctag ttatccttgc caccgtttgt tgttgcaact gttttttatt 70500 ttagccattt cgataggtgt cgagtggtat ctcactttta atttgcattt ctctcatggc 70560 taatgatggt gaacgtcttt tcatatacta atttgcctct ggtgaaattt cttacataat 70620 tggagtgctt gtttttttct gttgagtttt aagagtttaa aaaatacatt gtagatatga 70680 gtccttggtc agatacgtgg tttcaaatat ttctttcact ttgtagcttg ccttttcatt 70740 ctttttaccg tgtctttcac agagtaaata tttaacattt tagtgaaatc cagtttatca 70800 ttttttcttt tatggattgt gctcttcacc tagccctaga tcctgaagat tttctcctgt 70860 ggttctttcc taaaattgtt acagttttat gttttaagtc tgtgatccat tttgagttaa 70920 attttgtata aggtgtgagg tttaagtcaa ggttcattgt tttcccaata gattaaattg 70980 cagcagatcc tttgttgaat aggctgtcct tcccctgtta aattgcgttt gcccctttgt 71040 tgaaagtcat gtgggtgtat ttgtgtgggt ctatttctgg gttctctagc ctgttatatt 71100 aattttgaac gaataaagtt ggcttatgtt taagttttct tggtagtagc gaggcaatgg 71160 tgccttctga gcccaggatt tcacaatttt gtgagtaaac tgtgttagaa attgtttgtt 71220 attcttttgg taggttgtct agttcaattt cattgctcat taatcttgct tatagatagc 71280 aaattgagag gcatctcaaa aatagtatct tttgttagct tatctcacag agtttggttg 71340 gagcagatat taaaacaaca aaccaaaaat aaattaaata tactagttag caagtttata 71400 ttgagggaaa atcaaaccat gtgaattgag ctccaatgat gtggctggcc ttgggtcaga 71460 ttttagtatc atggttcaac aaggtagcta ttaaaatctt catacttttt cttgaaataa 71520 ttctttagta gtcacatagg acagcacaca ctcatggatt tcttctttcc ttactgtctc 71580 tttattctca gcctcctgtt ccttctcatc tccctgacct tttaatgttg gccttccaga 71640 aactttagtc tttggaccta cctttgcact cattttcttg gtcatttcac ccaacataca 71700 gttttatgtt attttatttt ttttattttt gagatggagt ttcactcttg ttgcccaggc 71760 tggagtgcaa tggcgtgaac tcaccttact gcaacctctg cctcccgggt tcaagtgatt 71820 cttctgctca gcctccccag tagttaggat tataggtacg tgccaccatg cctagctaat 71880 tttgtatttt tagtagagat ggggtttcac catattggcc aggctggtct cgaactcctg 71940 acctcaggtg atccacctgc cttggcttgc caaagtgctg agattacaga tgtgagccac 72000 cacgtccagc ctacagtttt aaatatcaag tctatactga ggactcccaa atttttatct 72060 ccatcataga ctgatatcag cagtatatga gtgattcagt tgtttttgcc tctttgccag 72120 catttggtgt tgtcactatt agttcatttt agccatttaa tagaatatat gtacatatat 72180 atgtgtgtat acacaggcac acatctatat aactactcaa catgcctctg gtgagatgac 72240 caacaggtat ctcaaactta acctcttcct aattgacttc tgcatagcac tccagatctg 72300 ctctttcctc actctcctcc atcttgttta acagcagctc cattggccaa aattttggaa 72360 ttttcctcaa tcttttctct ttttcttaca ctccactgtt tatttaaaca gtaaggaaat 72420 ctcgtgaggt cttcagaata tatgcagaat taaatcactt ctctcttgat ccctgccatt 72480 ccccaggtac gggccaccat ctccttaggg cctcctgctt tcactcttcc catccctcat 72540 tctgtttcaa cacagcgtcc agagtgatac tttaaaaatg aagtctgata gatcatgtct 72600 tcggctcaga accatctagt agcatgccat ttcattctaa ataaaggcaa aagtccttat 72660 gatgagttac cgatcctcat gtaatctggc cttccatttt ccctctgatc tcattctcta 72720 ctggtctcct cattcaccgg atgcagccac accaccctcc ttgtttttct tcggacattc 72780 caggcatgct tcagtgcctg ggctttgcgc ctgctgcttc ctctccctga atacgtttcc 72840 cccacattgt ctataggatg ttctcccata cttctctcag atctcttgga tttaggcctc 72900 ctgggccacc atatttgaaa tatcagatta gttccccctc ccccatcatt cagcattcct 72960 cgtaaatctt tgctgtttta aaaatagcac tatcactgtc taacttactg tgttatattt 73020 tgttaatttt ctgtgagttc ttcttcacta gaatattctt tgtagggagg agtttttgat 73080 tgtttggttt ataaaatctg gaacaatacc tggcttatag gaggtgctca atttataatg 73140 gggtgaatga atgaatgaat gatgatgaga aagctgagaa tcagtaaagt gactttccaa 73200 aacaggtagt gggcagtata gagttgggcc ataaatagct gcaccataca acatcctgct 73260 agtttctaaa gcaaatgatt tgaaagaggc ataaaacata atttctgccc tcaggtagct 73320 catagttcag taaaggagtt tagattcata cctataacag tagaagtaat agcaccaaat 73380 gaaatatggt attatgaagt ggtacaaata atataaaaag atgaacagtg ttagtagtac 73440 atgtttagaa gggatttctg tggtgaaagt cactaggcac agtgcacctg gaggaccgat 73500 ttccattaat ttagaatggt ttaaagtaag cttttggaaa ctaggaagat tactttctgt 73560 aatcctttcc taggcctttg attctagaag gattgtgtta aaggagtttt aaatatttta 73620 tacagttctt aaacattgtt aagcttgaat taaatctttt attatgtctg gccatggacg 73680 tcattggatc attttcattt cttgggagga ttaataaagc acattccttc tgttgggcct 73740 ccagtgcggg gagggtgttg gccgagcagt ggctgagaaa acgtttttcc cctggtgttt 73800 tcaagaaccc tctttattag ctaagtggtg agacatgcca cctggtggtt atagtagtat 73860 catttttctc actgttcttg gtgcttttct tctcgttctg attccagtta tactaggaca 73920 actgctataa acctggaatg tttcacacta tattatttca gtaatttcaa aaacagcaga 73980 aatcactaag ctgtttggca caaagattcc tatttggaag gaatcagaca aagtgagtgt 74040 tgagaaagaa cagccaggca gaaagctttg catcagtctt aaagttcttt acatttcaag 74100 taagaggaat tgtgaaatcc ataagacatg tggggttttt ctattacttt ctccccagta 74160 tctattacaa agatcagcac atagtaggta ctcagtaact atttagaatg agtgcatgaa 74220 tgaatgaagt atgtgtgatg ttatggagta caaagttaga attagcaaca tgacctgaat 74280 ttagaagcag gtgggatact tatacttttc tcagtctgtg ggcaccacac cattgaagta 74340 tatgtctaag attaatttat atttggttgt ttgatttagc aaaacttgct gcctgttaaa 74400 aaagaaatta agacctgtca acttaaagaa tacattttgt gagttaagaa ctaaatgaca 74460 gtataattta ttacccaaag cagtttgctt ctgaaaatta aagagttcaa gctattaata 74520 attatgctgt gactgcaggc ataaactggg aatgtcctgg caaatgagga tgtattgtca 74580 cctttctcag cctgcctgtg tgttgttttt aagcttcact ctagtttata tattttaaat 74640 gtcataaaat accacatact tataagagaa aaggttctat tcattgctga agtggaagct 74700 tatcattaat ttttatttat ttattttttt ttccagtttt ggaattctta ttactttgaa 74760 cccaagaacc actgataact agcacaatcc agtgaaacag aggaagcagc agcttaatca 74820 aaggaaaaat acatttaaga ttataagtct ggttataagc ttaaaaagtg acccagaaag 74880 ggatatcatt gctaaaaaaa aaaatcccct tgtgacctgg gtacattttg caaagccaca 74940 ggtttgcagt gttacacaag ggccaaagga ggccatgagt tgtctttggt tgtggggccg 75000 gagggtaact gttcatgaaa atagtgagtg tctgaagatt aagaaaatca tgctgcagca 75060 gaggagaagg gagaggaagg caggaaggga aaggagatgc ctgagggtca aaagctgagc 75120 ccaagcctaa gcccaagctc aagttcaagc cccagcatgg cacaattttg tgaattaact 75180 caggctgagt tgcctccagt ctttggaatg tcatcttata ctggtactgc tgaggcagag 75240 ggcagtaatt ggttctttgg gataggagaa ggggcagttg ctgaaataca aaattaatag 75300 tcagcatccc aagttcctca attgcagcca aaatacatgt gttcaggcct ttcggcagta 75360 ccgcccccag aactaccagc tgtagtgtgg tctattccca gacagcaaca tgcaagaata 75420 agtttacaat acactcagcc cttgtggctt aagatcaggg gctcagaggc tgtgacaact 75480 catgatgctg aaaatgtatc caatgaaaac gaagtactag cttgtttagt agtaacgaag 75540 tactattaat ttttaatata gtctgatact ttattttcta attgtagaag caacattctt 75600 agctatatct ttctagaatg ttgaggcaaa agagtaaatt tatagtgatt ttcactgtta 75660 ccagattgct ggaataggga atttctggta gcaagatggg aatttttaag ttggaagggt 75720 ctaacacatc atatagccgt ctccatctca ttttttttgc tgaaaaaact gagcccttgc 75780 aaatgtcagt tgcaaatctg ggagtagtac tcatgtctct gaagttgtta tatagaattc 75840 tttttattta ttttaataac aatatttatg atagttgaaa ctttttgagt gcttactata 75900 ttttatttca tgcattatgt tcagcacttt acatgtttta tctcacttga tattcacaac 75960 tttatgagat tggcactgtt attgtagcca ttttatagat gaggaaactg aagcttagag 76020 agttaaataa agagctcaaa atctcacatc tagtaagtgg caaaaacagg atttcagctc 76080 aagcaatctg attccaaaac agactttttt cactgtgctg ccattctttt gcctggtttt 76140 tctgttaact tcttaaatat atgtcatgtt tcatgcttac ttcctcattt tcataaatat 76200 attacctgct cacttataca ttatattgct tagaaacaaa cccaaccctg ttttcttatg 76260 gactgtatcc tgaaaatcac tgtttttaat atgtggttaa acaagtgttt tattagtgca 76320 tttatataaa ttatttaacc aaaacactta accggtgaaa gtgctttact gtgtgagaat 76380 gtgcatgttc taagaacctc taatttttaa acctccctta ttctcagcct tatatttgtt 76440 aaaacctgtg tgttaacaca gatgcaccca tgttaggggt taattagaga aaccaacctc 76500 tttatagatt agcttgttca tctttaagtt gctaggcagg cactgtaaat tcagagaaca 76560 atctgattgt aagccacaaa tcaatgaaat taattttggg gttgcctttt aaaatagtgt 76620 cacaaaattt aaggataaag aatgcaaaaa tgatgccaat tatctcatca cattagtttt 76680 gatttaattt ttttaatttg aaaaaaccta ctcttaaact taattgattt ttttaaatat 76740 aagtttggag ataattttta attcagtaaa gttatagtga ttgaaaaagt agtttataat 76800 ttttaataaa ttgatcttgt tttaattttg agtcatattc tagaagtgct tctttgcaaa 76860 ttggtaaatt gcacatacat ttccacttat atacaagata attgctatgg ttggtttgta 76920 taatagatgc agtgcatctg aagagctatt ttatgagaat attgtttctt gtatctgtca 76980 cgagccaaaa agaatatttt taagaaagtt atattcttgg tgatagaaca gctgataatt 77040 tagaaacaac tgtaagacag tccacttttt ctgattatga aataatacca tagttaagtg 77100 taatttccta taatagaata aaaacacgag ttctagtttt aggggaggca tgttgttacc 77160 gtaccttaga atttctggaa gatgacatat tcatgctttt cctgataact gctgagtctc 77220 ctgctctgtc tgccaatcca gtcaagaagc ctttgctagc aatcaattaa taatacgttt 77280 catttataca tatttcctat atatagtatg ttattgatta tctcagtacc actgaagaga 77340 ggttatctgg gtcattggag ctttgcttct agatttgtga agccataaac ctatatattt 77400 aaaataggag gccaaaaaaa aacgaccatt gctttatata gttagatttt cagtgaattg 77460 agagtttatc atttgtaatt atacattaat caaatataag gcataatata cccccctgct 77520 tatatcagca ccatttcaaa tgtaatgtta aaaaataata aatggagaag tagatagcta 77580 acaagtaggc ttaatttaat aagacaaagt aaatggcatt tggaaacctc atggatttaa 77640 tgttttattt aaatgatttc tgatttttaa aaagtaaata ttgtttccag aaggctgaga 77700 aacaagttag tagggagatt ttttctttgc aaaaaaattt tacagttgtg tctttaacat 77760 tgtaccacaa actgttgtcc taccagtctc tttgtaagaa agctatagac atgttgggaa 77820 tgaatgagct ctttcctttt taaaatatca gttttacatc attcaggttc caatcgttgc 77880 acttactgct actgcaagtt cttcaatccg ggaagacatt gtacgttgct taaatctgag 77940 aaatcctcag atcacctgta ctggttttga tcgaccaaac ctgtatttag aagttaggcg 78000 aaaaacaggg aatatccttc aggatctgca gccatttctt gtcaaaacaa ggtaaggatt 78060 taatggttga tgaattttgg taatgatttc cttttttttt ttttaacaac ttatgtattt 78120 tatgttattt acgatttcct tctaatgcat atttaacata tttcaaattc cacctagttt 78180 tggttcaagt caagcatgat gttatataat caattcagtg attgagacta gtgtattttt 78240 aaaagcagaa accaattctc ctaatatttt aataccccat tctgttgctt aaacagggca 78300 tatactattt atttttattt tttaaaattt tacttattta tttatagaga cagggtctct 78360 ctgtcgtcca ggctggagtg cagtggtgtg atcacaactc actgcagcct caaactcctg 78420 ggttcaagca gtcctcctgc ctcagtctcc caagtagctg gaactacagt cttgcaccac 78480 catgcctggc taggacatat acttttaatg attgataagt aaacaagcaa acataaaatg 78540 actctttcat ctgaattctg tctagtttac taattacatg acttcagtct taaggagctt 78600 agaaaaggtc accttacaaa cacagtggag cctgtattgt gttccaagga ctattgtagg 78660 cgctttctat ataaaatgat ctaatttaat ccctataact gctcagtaag ttacgtatta 78720 ttttcatttt attgttgagg aaactggcat tagtactttt ttctgtttat tttgtttaaa 78780 ggcattttaa atatatatgt taagaagttt tcaaaagcct atattttact ttttataagc 78840 ctttatttta ctatttgaga cagtgtcttg ctctgtcacc caggctggag tgcagtggcg 78900 caatcccggc tcactacaac ttccacctcc tgggttcaag ctattctcct gcctcagtct 78960 cccaagtagc tgaaattaca ggtgtgcgcc accatgccag gctaattttt gtatttttta 79020 gtggagacgg ggtttcacca tggtggccag gctgatctcg aactcctgac ctcaagtgat 79080 ccacctgtgt tggccttcca aagtgctgga attacaggtg ttggccactg cgcctggcca 79140 gtttataatt ttaaacatta aaataaatgc ttcttgtcca atcatggtgt ctcacaccca 79200 gaatcccagc actttgggag gcagacgttg gagaatcact tgaggccagg agttcgagac 79260 cagcctgggc aacatggtga atccctgtct ctacaaaaaa tacaaaaatt agctgggcat 79320 ggtggtgcat gcctgtagtc ccagctattt gggaggctga ggtgggagga tcatttgagc 79380 ccaggatgtt ggggctgcag tgagctgaga tcacaccact gtactccagg ctggatgaca 79440 gagcaaggcc ccgtttcaaa aaaaaaaaaa aagcttctac caatacaaac acaaaacaag 79500 catagacaaa tagagtttaa agaacatcat tggtgttttc ctctaaaggg aatattgatg 79560 ctaggccaag aaaatcctgg agttattctt gaggacctta aggaataatt gaaatgtagg 79620 atttgctcct ggctttcttg tcctatattc agaataaaac aagaatggat cgaatatatt 79680 ctgagtgttc tggccattct agtgctctct gaagtgagta ctcactgtgt ttcacttccc 79740 tttcatccta aagaggaaaa gttcttttga agaaggctgt ttgtcctagg ttagagtctc 79800 cacagtcaga tcattatctc ctcctaatct ttgatcctgt tcagtctcta tggtactttc 79860 ccttataata acactctcta tggcactttc ccttataata acactctcct ttttaaagca 79920 gtttgccttt tttgtgtgta atattgttct cctggttttc tgacgtcctg gtcctcttat 79980 aatcctatgc aaatgtttct ttctgttttt catgttgact ctgctaattg aggtctttgt 80040 tactttttag ccgagactat tataatttcc ccaacagata cccctctccc cagtgcccct 80100 tgttgctttc tatgcagttt acaaattatt gtctgcaaac acatccttaa gtctggaata 80160 cctttctgga actccttact aggaaataaa gaccagactc agtgtaacat tcaacagtat 80220 tgaagatcta ggtatttaat atgaattttt ttttttaagg agatcaagaa agatttttgt 80280 acccattttt aatcctccaa gaagacttag gatagcagga aaccattgag agtcagaatg 80340 ctttctacag atcttaggtg aacagaaact ttcctcttca tgagcagtga ggtagagggt 80400 aattaaggct tcagagcatt gcccgttatt tccatcttct tcccttcctt taattctgct 80460 aaattccttt aatttgttta tcagtattca agtattttta tccattgagc taaggtgttt 80520 cttaaactaa ccctattttg ttaaagtctt aattataata tattcatagt acatttaagt 80580 gagatagatg agtctctcat ataatttagt ggttagatta gattagaatt ttctcccctc 80640 agaaaattaa gaggaaataa aagtctgtag caaatcactt ggcaaaataa tggctccttt 80700 tgtaatagga atttttactc ttttgattta tctgttacat aagttcaaat ttttacatat 80760 tttccacctt ttttaaaaaa gagtgatatg tagtcaatat caatttgagc aacactgttg 80820 catataaatt gaaaaggact ccaattttct aattccgtac ctcagttgtg atcactgttg 80880 gtattttggc atttatgtag acttcctttc tctgacccta ctactgtgca gatatatagt 80940 tgcagttttt tgttgttgtt aagttgatac agaaatagtt gcatactata tccattattt 81000 atgcaaattt tttttcattt aaagtatctg ctatctttcc atatattgca ttttcttaaa 81060 ttagagcctt aatatatagg atattacaat atctaggttt tgttgagtag ttttttcttc 81120 tttgaaaaca tgtttttaaa ataaggtttt tttttttttt tttttgacat ggagtcttgc 81180 tctgtcgccc aggctgtaat gcagtggcgg gatcttggct cgttgcagcc tctgcctcct 81240 gggttccagc gattctcctg cctcagcctc ctgggtagct gggattacag gtgcatgcca 81300 ccatgccctg ctaatttttg tatttttagt agagacgggg tttcaccttg ttggccaggc 81360 tggtctcgaa cttctgagct caggtaatcc gcccgccttg gcatcccaaa gtgctgggat 81420 tacaggcgtg agccactgtg ctggccttaa aataagattt ttatacacta aaagaaaact 81480 tacatttttc actccattaa gtagttcact gtgaattttt gatattgaag cccatttggt 81540 tgctgtcaaa aatagatttg aacagattat tcagtatgac tcttgtagtg aaattattgc 81600 cttgtttcct ctgcttaagt tttcagtggc ttttgccaca gtccttaaag gttttataat 81660 ttttttaatg tttaattttt aaatgtttgc ttaatatttc ttagtatgag tgtagataat 81720 gatgaacatt tagatgactt tttactatta taatgttgca gtgaatattt gtttacattt 81780 atcttttggc caataagcaa atatttttgt aaattagaat cctaaaattg aaattggatc 81840 aaaagttata tgcacttgaa attgattaac ttttcctaaa tctaaaatag tatagtcttt 81900 tttatattgt cagcataaat gaatgcactt atgtaaatga atatttttag gcgttaagta 81960 aaatattctg tggaaattga acatttaagt tgtttatact tctatggaaa tcgtttacgc 82020 ttttaataaa gaagcacaag tttctacaaa atacattcta acagatgttt tctataacat 82080 tcagtctcaa gattactagt aaatacttct ttgaactgta aaagcaatct ttcaatatta 82140 taagaaagct cttgctttag taaacattta gaaactcagc tttattatca taagcaagaa 82200 taagaacagt gtaacaagtt ttatgcacac tcctttgtaa accctcacca gactaattgt 82260 taatctggtg ccttgcattc cccaaagtat ttgtatctgt cgtttataag tttttatcaa 82320 ggtttcagct aaaacaaata aatttgtttc tggttttagc tttaatttga actgaaacag 82380 tcaaaactga gttttgggga cttcacacaa ttcatttgga tatttgattc tccataatgt 82440 tttaaatttt catgcactta aatatatcat tatttttgat aggctttctt cctttagtct 82500 tttctttaga aggtagaaag gaagaattaa ataagataaa accaaacggg tctgaagcat 82560 gtataaagta tatatgtttg ctcttttgtt cttctttttc tttagttccc actgggaatt 82620 tgaaggtcca acaatcatct actgtccttc tagaaaaatg acacaacaag ttacaggtga 82680 acttaggaaa ctgaatctat cctgtggaac ataccatgcg ggcatgagtt ttagcacaag 82740 gaaagacatt catcataggt ttgtaagaga tgaaattcag gtatgaggat caatcatcat 82800 tgctctccgt tgctcatagt ggaagtggat atttctcaaa tgtttattta ccagatcttt 82860 attgaatact ttctttgtgt tgaacataaa gcagtccctc tgataaatgt gggagaacaa 82920 acttgcagat tagtataaat agcaatctgt acctagtgct taggtgcaca gaggagggag 82980 gaatagctct gtcaaggtag ttgtgtaatg ggggtggtcc atccaggaaa attcaattag 83040 agtccaaaca tgtaagtaga agtttttcaa gtatgccagg ccagtaggtg atgaggggaa 83100 aggaattggt tatagaattc caggaagaag gactagcagg tgcaaagaca ctttgatatg 83160 agaacacata ctgggttcag gaaatgtgac tggtatggaa tggttggagg gaaagacaat 83220 gtggggtagg aatggcacaa agtatggaca aagaggcagg gtggaaccgt tagagacttg 83280 agagaacagt tgaatgggtc ggttggccag gttatagatg gctttaaaac ttgcaaagaa 83340 gcagtctggg cttggtatca tatacctgtt agttttcact gactacttta gccttagaat 83400 ttttagttta gatacaattt tctgtaatag gtaaaacgga ttaaagtaga ataactctgg 83460 ctgaagttaa tgtgagggaa aaggaggtac aagagtctcg tctctagacc ttgaagacac 83520 tccctgttgg ggtcttataa tccttggagt gccgcagaat catttgaaaa ccatcttgat 83580 gtactactct gtgtttttaa ataagataat aggattatag aaacattaga ctggcagcaa 83640 taagttggat tgatttgaag aagagaaact gaagaaggga aagggtatcg atgcagctat 83700 tgtgaaattc tacagttgag attcctgacc tgattggact ggctcagtgg gtgtcataga 83760 ggatttattt gggaggattt aagttcaagg cacatgagta ggtttaagtc aacaacttga 83820 cactgtcaac atgaaatcca cactgtaact ataagtccga ggaagagccc tctcctgaag 83880 ttaggaattt aacttcagct cttgcatttt ctgtcccacc ggtcatccat ttcttctcta 83940 tccatctcct tttctgatat ctagttgtta tcagtgttgt tgaaaagctt aagtatgatt 84000 catattcact gtctataaag ttcactacac atagtcatgc tgtaatgcat acccgcctga 84060 aagcatctgg tctctctttt ccttctttcc aaagataaga ataccattca cagctgttta 84120 gaatagaaat tttatccaaa ttcttcagtg tttatatttt tgttctgtta tttcagtgtc 84180 ttgaatattg tcaaatgaca tttattagct actactggta ctactgaatc ttaataatca 84240 atcttcaagc cattaactga ccaatggttt cttctatctt aatgtattag taattattca 84300 tttagagtaa aacatctccc agaacatgaa agaatacaaa ctttattcat gttacgttgt 84360 gacaggagac tttgttggat gcgcctgatt ttcctgccaa ttcacagctt cattaaaaca 84420 gtaatgcttt gaaatatggc ttaggaaact tcacaatgat cattaattac acctaatttc 84480 tggaagagta tatgcatgta tgtgttgcgg tattctccct tgctgtggca ggatgtcaca 84540 aatttttatc cacattacga aaatttaaaa attgatatgg ttttttctcc ctacgttgat 84600 atcagatatt ttgttttatc tgacagctgg cccaatgtac tcctactttg ccattataaa 84660 gaattcaaaa gcttcatatt tgcattgaaa gttctcaaac actttgtaaa gatgatgaaa 84720 gtatgtttca tcatctatgt agaatagtca ggtgttcttg caattgatta cttgctaccg 84780 agaattgaat acctactgag tgcataatgt atagaattct agatattcac ttttgtgtgt 84840 ttttacagtt gttatatacc ttagtgtggc tctaaaagtg gaggtgacag ctgtagctct 84900 taatgtctta cactgagtga tgtttagaat cttaaatttt cttttataat tttagaaaaa 84960 agtatacttt tctttcttat ttttataacc agatccaaac acatttgcat gtagataggc 85020 atttttagtc ttgaacattc atttttactt ttaatcctca cttttattag tttcgtatct 85080 ttttgtattt catttcccct ttcaagatgc cttgagtcct ttctttttag gaatgatgtt 85140 gtgaataaat tatttgataa aatgtcttta cacctgagag tttataagga tagtttgaaa 85200 atcatgtctg taaaataggt tgatctcacc taaaaataat accatataat taaaattaga 85260 attattattg tgttgcttat tgactcttac atatatcaaa aaattgctga gtcttattca 85320 gccagagctt ttacttagta tgatattcat tcctatattt acttttttct cacctttctc 85380 atactttctt ttacttactc agcattttcc tcctttcctc cctcctttct tttcttcttt 85440 ccttcttttc tcttcctttc gtattcctgg tccatcttag catgtaatct ttctttatga 85500 aatggcatgc agataggtct actgttctta cagtaaaaaa cttcaaggcc tcatgtcttt 85560 cccacttctg tttcccattc acaacctttt tagctgattc ttttggtact ttaccactat 85620 atcttgccat agtttatgta cctggctcct acttaatttt ttgtttattt gtgtattagt 85680 cgtaggcatt atttatcgac tcttctctct gaaagatgaa aggttagctc tctttcacat 85740 tcttaactgc ccttttttct taccttgtcc atgtatttct aacccccttt cctcctaata 85800 tgtttatgtc ataattttgg ctagattagt gtatacgatt tacataatta ttactctgta 85860 aatgcttttt atgatctctg agccatgtag tatattatgg ctatttttct ttcttatcta 85920 tttgtatttt tattgttatt acctaaaaaa aaattttcta tgtcttatca ctaattcttc 85980 cctaaaattt cccacaattg tgtaaactta cctcagtata ttcatagata tgagacattc 86040 tatcaatttt accctcttaa agatgcagag ataatgcatt atgtttcatc ccaccatctt 86100 taatgagaag cttccatctt agattaatat tagagaatgt taaaatactc tgcaatcagg 86160 taaggacgct tgaaacttca ttataatgca aaagttttct ttaacacaat aaatattttg 86220 aacccctttt gtgtcttgta ttcataggag ttcagataga ccactttatt tactattttt 86280 tatagagagt gaacagaaat cccatttcta gtcaccagtc cttaatctgt aaatcaggca 86340 gataatctgt aaatgattgg ttgaaatcac attgaattcc actttgtgcc agggacttaa 86400 gttaacgaac aaattattct tacaaaaagg tataaatgta aggttttcat tctgctaaat 86460 atgtttgtca aactgtgttg tgatttgttc tcagtgtgtc atagctacca tagcttttgg 86520 aatgggcatt aataaagctg acattcgcca agtcattcat tacggtgctc ctaaggacat 86580 ggaatcatat tatcaggaga ttggtagagc tggtcgtgat ggacttcaaa gttcttgtca 86640 cgtcctctgg gctcctgcag acattaactt aaataggtaa aaaaaattta ttgtttttac 86700 tcttgcagat ttctttcttt ctttccatat aaacctcaaa agtgtttgag gctatttcca 86760 gtatcccaag taatttgtga gtgcatttaa agtaaaaaaa aaaaaaaaga aaaataaaac 86820 ctccccaaat ccagaggaca tgtaagaaga acatttgtgg taagagttgc cacttggaga 86880 tgagctaatt tcagcatgcc ttagttagtg tgaggaatta actaaatcag gacaatactt 86940 gggcctgtca cagagatcct atggaatact ttcctaccat tgtgcattaa tgaacaggtt 87000 cttttcctct cctcagatcc tgtcaagttg cgatgtcttc agccatagtt acttcaacta 87060 ccactgattt tgttactgat tctttcttcc catgctacag tggtgattat tccagaggat 87120 ttctctcagt ccctatttga ctcttgttac tatttgtttt cttggttagt tccatgagac 87180 catgccagtt ctccttgact gtgtatgaat cattgtgttg cactgtactg acagactgcc 87240 gtaagtcaat attaagtgtt cagtatctaa gtgcaggaga acctttctac ttaagtactc 87300 aacaagtagt ttgttggcac ttaagttcta tgagattttt tgttgtaaag gaaaacatta 87360 tcttgcaaag attttggggc agcatttacc aatactttgt tccttcatcc gtaggaaaaa 87420 gaatctcagg agaaaaacct atacatggta accaatgggg ctgccaagct gatgaagtat 87480 tttcagagta cacctttgtg tagctgaata aattgagatc ttgaatggac atattagctc 87540 attttagtaa aatgataaga gagtgcctcc cactacagtt tttgttttta tgcatcatta 87600 aacaatgtgt ttttgattgt ccactgtgtt ccatgaacta tgctatgtgt gggagatata 87660 gtagtaaaga aaagcaaagt acctgcttcc atagaattca gtataatggg aatggtaatt 87720 ctttagagaa tcacataact atggatacat aggcttcatt ttactgttct ccttttgtgt 87780 ttgaaaatgt caacaatcaa aattttgtaa aaaaggaatc atgcaacata tttaaaatta 87840 taactgtgtt aagtgtaatg aagggaaatt gcactgagta gtaagaatat ataatggtgt 87900 gtggtatttc ccaagttaaa aaggtcagat aaggcttcct tgtggaagtg atagttcaaa 87960 tctgaaagaa gaataggaat taattaggta aaaatgtttg atgcaaattt taagattttc 88020 cttctgagta gtcagtagct tttccttctt aacatagaag atgacaaaac catccttttt 88080 ttgtacataa caattcttgt tttcctttag acagttgtat ctgtcaagct tcttatgatc 88140 taatttaaat aattgggata gaacacagct gtacatgtta ctattaaata tggaatatat 88200 caaacataag ttgattccta ccagttctga ttttatttgt gtattttgtt aaaggtactg 88260 aggacattaa tatccagttt tatattgtgc atttgaaggt tcatcaataa atacaattct 88320 tgtttctctg ggtcttaaaa gatattttaa atggttatct cattaagatt taacaggaaa 88380 taacagtgat tcaaatcaaa tagtggtgcc agaaacccat acttgaattt tgggtataga 88440 caggttaccc tttgcatcaa tcctgaggaa actaaaacta taggattaat caggataaaa 88500 aagaattgag caaggattca ggagggatct gtatcatcct ggtgacaacc ctcttctaga 88560 aaaaactaga aagtctaaga ataaatgaag ttgctggttc tcacctggaa aggtcagtta 88620 ctcacaaaat ttttagagtc tatcttatgc cataattcta tcactgagag aagaaacttg 88680 tccagtcatc atgtaatctt catgtaaatt tatgttttta attgcagaat tcataccaca 88740 ggcaaagtcc caatgtctgc atttgctgtt accttaaata gtcaaacccc aaagttattg 88800 taatcttttt ttaacagaga ataatttgca gagtaatctc ggtccggtag atctttcagt 88860 ggatccaaat gattgccatg aatggtttag aattttttta attttcaagt tgtttttatt 88920 ctgtggaata ctggacttat ttttgtagtc ccaaaagaaa aataaatatt tatttatttg 88980 ccgttaagag ttgtagtttt gttttctcaa atttgtcctg acactgacga gattagttaa 89040 atgtaggtca tctgaaccaa atacaaggaa ggaaggaccc agttctgaag agtgtgggca 89100 tttcttttct tgtttttttt tttttttttt tttttttcta taggagggga acgaggtgaa 89160 ctaaacaaac aaaataaagc aaaaaagaac tgatttttat cccttgaggt agaaagaatg 89220 agattacagt ggaccccctt gtctgcattt tcactttcta tgttttagtt actcacaacc 89280 acgtccaaaa tgttaaatag aaaattccag aaataaacaa tttataaatt ttaaatcagt 89340 ggtggctttg agtactgtaa tgaaattttg tgccatccca ctcagtctgc ctcgacttcc 89400 cttagaatca tccctttgtc cggtgcattc acgttgtatt tactccctgt ctgttagtca 89460 cttgttgcag tatcacagtg cttgtgttca agtaacgctt attttactta agaatgaccc 89520 caaagcacaa gagtactgtg cctaatttat aaattaaact ttttcatagg tatatacata 89580 taggaaaaaa cataatacat acaggatttg gttggtacta ttctgcggct tcaggcatcc 89640 actggacgtc ttggaatgta tcccttgtgg ataaggagga actgtatatg gttaacctag 89700 gagctagagt caacagttgg aagagacttt ggggataatt acatggaagg gcatggtggg 89760 tggtcgtttc agatgacaag aatgtttttg aataacggat catttgtgtc ttcagacttt 89820 ccagaactcc ttgagaatta tgcagaggta tttaatcagt cagaaggttg aatagtcaaa 89880 ttattagtga gtgaagtcta ttttgatgag gattttacta atgctgtccc ttagatatta 89940 taagtaaatc gttgttttct tttgaaatat ctgaaaccta gttaacatgg actttcattt 90000 gttcttgtaa agatatgcaa agctatttgg gagattgtca tcatctgata tttgatattc 90060 atgggctttc ttcacagaag actagaaatt aacagagtca tgatgaatta tggctgcatt 90120 gactttaaaa aacaaacacc tccttaatgt tatttaacaa ttttgaataa atttgatatg 90180 gcaaacaaat cagttataat cgattgagaa aggaacttaa ttctaatact tgactggtgt 90240 cccataataa cccataatac taagagacag ttttggaggg cgagaagtcc tgaagagctg 90300 atagagataa aggttcaaat ttgagcttct ttcagtgttc cttacgtcaa tgcttttagt 90360 ttctcataca aaataaaata aagaataacc tttttactgg gaaaaggtaa aaattaataa 90420 attgtagaag cattgtttga agccaaaaag tgtgtgacat gtaaattgaa atgaaaaacc 90480 ttagagtttt tgatactttt tcaaagcagc taaagaattg atacttggac acaggaagaa 90540 ttttttttca aaagcaattt ttataaaatc agaaaaatgt ttacctcttg ttgggggcat 90600 tgactggaaa ggaatacaac agaactttct gagatgctag aaatgttttt ttatcttgat 90660 ggggtgtggg ttttgtagat aatgaaaaat aaacagtaaa aaataagtaa aaaaaaaagt 90720 aagaaagttg ccaatacagt tttacatatt cctgtgatgt ttttaatcga caggcacctt 90780 cttactgaga tacgtaatga gaagtttcga ttatacaaat taaagatgat ggcaaagatg 90840 gaaaaatatc ttcattctag cagatgtagg agacagtatg tattatttat tttatgccaa 90900 tagtatggat ttatggatga tgctctttta agacaacaat ttggctaaat aattatcagt 90960 attttgaaaa aatattttgt tgctgttaca tgtgtgctga atttttaagg ctaacttctt 91020 tgtgtctgag taaactgaag tcaaataatg aagtcccaag tgaatcaatt aatggtgatt 91080 ttacctcatt attttcagga atgaacttaa catatacgtt tctgttcttt tatttaattt 91140 aaaattttgt cttgggtaga atcatcttgt ctcattttga ggacaaacaa gtacaaaaag 91200 cctccttggg aattatggga actgaaaaat gctgtgataa ttgcaggtcc aggtaaagat 91260 ttcttattat agatggacat tctaaaagtc tttctttctc ttccttttca tgtttaactg 91320 aatttttgtt gaatgataag tatttcagtt ttttaaacaa aacaatgaat gtgtttagat 91380 atgagaaagc aaacaatatt aaagtatttt gcttaaaaaa tagataaagc aataaaatgg 91440 tagccctaaa tctaaacata tcaatagtta tgttaaatgt aaatgatcta aaatattatt 91500 taaaggcgta aattgtaaga attggtttaa aaacatgacc ctgttctgta cgttgtccac 91560 aagaaatcca ctgtaattat atagataggt ttaaaaaaga atgaaacatt acattccatg 91620 aaaacattaa tcaaaaggaa gttggagtta ctttaatatc agacaatgga cactttggag 91680 caaagaatat tatcaggata aagaaggata ttatatgatg taaaagaatc atttcaccaa 91740 tgtatcagtc agggttcacc agagaaatag gacgattgat attatggaga tatatatata 91800 tatatatata tatatatata tggggaggga aaggaagaac aaatatgggg agagagggat 91860 gaggcgactg attttgaaga attagctcac gaaattgtgg gggttggcaa gtctgaaatt 91920 tgtagagcag gtcaataggc tggaaactca ggcaagaggt gatgttgcag tcttgaggca 91980 gaatttcttc tctagcaaac ctagtttttg ccctttagtc ctgccactga gtggatgagg 92040 cccacccaca ttattgacaa taatctcctt tacttaaagt caactgatta taaatgttaa 92100 tcacgtctac aaaatatttt acagcaacat ctagattagt gtttgaccaa acaactgagc 92160 atcataggct agccaagttg atgcataata ttaatcatca caaccaagaa gacatcatcc 92220 taaatatata tatatatata tatatatata tctacttaac aaaaagactg acagaactga 92280 aaggagaaat agagaaatct acagttacat ttggtgactt ccagcatctc tcaataatca 92340 ataaaactga cagaccaaaa aatcagtaag aagacagaag aaatgaacag gattatcagc 92400 atgctggatc tcattgacct ttttagaaca ttctacccaa caacagtaga gtacacattc 92460 aagtgcagat gcagtattca tgaacatgga tcatattcag agtcataaaa caaaccttaa 92520 caaatttaag aatcttgtat ttgtatattt tttgactaga atggaattaa actagaaaac 92580 aataacagaa agataacaga aaagtctcta aaccttagaa attaaataac acacttataa 92640 ataaatccat gagtcaaaga ggaagtctca aggcaaatca gaaaatgttt tgaactgaat 92700 gaaatgaaaa tacaaaatgt gtgagatgca gctaatgcaa tactgagaag gaaatttata 92760 gcattaaata cctatgtaat aaaagaagaa aggtctcaaa tcagtaccta agcttacatc 92820 ttaagcaaca agcaaataag agcaaaataa atcaaaatga agtaaacata aggaaataac 92880 aaagaacata agtcaatgaa tagaaaagct atggtcatac cactgctgtc cagcctgggt 92940 gacagagtga gaccctatgt caaaaaaatt taaaaacaaa gcagcatgca gcattcattg 93000 tcagtgaata gaaaatggga aaacaataga gaaaatcaac tcaaaagctc attctgtata 93060 aagatcaaca aaattgatat aaacttctaa caagactgac ggaaagagaa aagacacaga 93120 agaccaatac caggaatgaa agagggaatt tcactacaga cctcccaggt attactaggg 93180 atgataaggg aacactatga acaactcaga acataacttt aataatttag atgaaatgga 93240 tcaatttctt gataatctca agctaattaa acttacagtg aattagataa cctgcatagt 93300 gttacaacca ttagagggat tgaattctat gttaaaaatc tctgaaaata aaatccccta 93360 gcccaaagaa tttcaatgac aaattctacc aaacatttag aagacaaaat aataccaatt 93420 ctatagcatg attccattta tataatagtc tttgaaacat aaaactatac tagagggatg 93480 aagaaaagat cagtggttat tagagattgg gggagggaga aggtatgatt ccaaaggata 93540 gtacaaggca gtattttgga gtgatagatt tatcgtgccc tgattgtgat gggagttaga 93600 tgaatctatg gatatcttaa aatgtgtaga actttacaca tacatacaac caatttgcct 93660 atgttaattg aaaaaataaa ataaaaacaa attatttacc tggtgggtta gctacgtacc 93720 taagttcaat agctgcgtta ctgtaagaca aaagaagcat tattagggat ggagttgttc 93780 tctgtgtaat gacaaatact tcttcactaa gaagacagaa ttgttttatg cacctttaaa 93840 aaaaaacaaa aacaaaaaaa atacaaccaa caaacagtaa cttgctggtg cggtggctca 93900 cacttgtagt attagcactt tgggaggctg aggtgggagg atcacttgag accaggattt 93960 ttaagaccag tctgggcaaa aaaccgagac tgtgtctcta caaaaataaa aaataaataa 94020 aaaaaattag ctaggcatag cattatgtgc ctctagtccc agctactctg gaggctaagg 94080 tggaaagatc gcttgagcct ggaaggttga gactgcagtt gcagtgagcc atgatggcac 94140 cactacactc caggctgggc atcagagtaa gactctgtct cacataaaaa aaataataat 94200 aatgataaaa actagtctgg gcatggtggc tcacacctgt agtcccagtc ctttggaagg 94260 ccgaggcaag agaattgctt gaacccaaga ctttgagaac agcctgggca acatagcaag 94320 accccatctc tatttaaaaa aaaaaacaaa cttaaaaatc cagcaaatac ataaagcaca 94380 aagccgacag aagaggtgga gaaatcaaca aatccaccat caaagtggga gaatttgata 94440 taattttaag ttattggtag ggtaaacaat ccaaaaatta gtacactgta gaaaatttgg 94500 tcaacatagt aataagtttg cttattacta tttatcagta tacatagtat actgatttat 94560 cagatacata gtatatggag ccctagagca agcaactata gcagtgtatc tcaagtattt 94620 ttacttcatg acccacatag caaatgatat gtgtatataa cacactgggc taattgtcag 94680 agttcagttt ctgtccaaaa ccctaagatc tggagtgatt aacctttcag cactcttaga 94740 actcacttgt ttgtagcaca ctgattgaga agcactgaaa gacttcactc ctcaaacata 94800 catggaatat ttctaaaaac tatgtattgg gccgggtgca gtggctcatg cctgtaatcc 94860 cagcactttg ggaggccgag gcgggtggat cccgaggtca ggagatcgag accatcctgg 94920 ctaacatgat gaaacgccgt ctctactaaa aatacaaaaa attagccgga tgtggtggcg 94980 agtgcctgta gtcccagcta ctcgggaggc tgaggcagga gaatggtgtg aacccaggag 95040 gcggagcttg cagtgagccg agatcgcgcc actgcactcc agcctgggca acagagcgag 95100 actctgtctc aaaaaaaacc aaccaactga acaaacaaaa aaactaaaaa acaaaaacaa 95160 aaaaactatg tattagagca tgggttggca aactatggcc tgtaggccaa atctgcatgc 95220 tgttttattt ttttttattt ttttgacata gggtcactac aggctgtcac acaggctgga 95280 gagcagtggt atgatcatag ctcactgtaa cctcaaattc ctgggctcaa gcaattctct 95340 tgcctcacct cagcttccca agtagctaca ggcatgcact accagaccca gttaattaaa 95400 acaaattttt ttttggtaga gacagtctca gtatgttgcc caggctggtt ttcaaactcc 95460 ttgcctcaat cagtcctcct acttcagcct cctaaagtgc tgggattata ggcatgagcc 95520 atcacgcttg actaatgttt ttgtaaataa agttttctca gaacacagcc atgccttttg 95580 tttatgtgtt atgtagggct gcctgagtta agtagttggc tgcaaagcct atcatggcct 95640 ataaagcctg aaatacttac tatctggtcc tttatagaaa gtgttttctg accctgtact 95700 agactagctt gtctcaaaat tcttcaatga atttggaagt tttctcacca cattttctga 95760 ccataatgca cttgagttag aagtaaataa gcagataaac aacaaaatcc tcatgcattt 95820 ggaaattaaa aataacactt aaataattca tattcaaaga aaaaatcaaa ctggaaatta 95880 aaaaaaattt taaacctaca gataactaca ttaatatgca ttaacatttt tagaacttag 95940 ggatagttac aatgatatac attaaaactg gtaagaggct gggtgcgttg gctcacgcct 96000 gtaatcccag cactttggga ggccgaggct gggggatcac gaggtcaaga gattgaaacc 96060 atcctggcca acatggtgaa accccgtctc tactaaaaat acaaaaatca gctgggcgtg 96120 gtggcacgcg cctgtagtcc cagctacttg ggaggctgag gcaggagaat cgcttgaacc 96180 tgggaggcgg aggttgccgt gagccgagat tgggccactg cactccagcc tggcgacaga 96240 gcgacactct tgtctcaaaa aaaaaacaaa acaaaacaaa aaaaaaaact agtaagaggg 96300 cccagtggct cacacctgtc attctagctc tttgggagac tgaggagaga ggatcagttg 96360 aggccaggat tcaagaccag tctgggcaac ataacgagac cgcatctcta caaaatttta 96420 ataacaacaa caaaaaaaac tggtaagagg caacattgaa tagtactttg tgggagttta 96480 ttagcttgaa atactcataa tagaaaagaa aattaatcag ctaagcatct cactaaagag 96540 attaggagaa taaacctaag catagttttt ttcccccaaa cattattata tctggaatat 96600 tgaatgcatt cttattgcta tttcaaagat acttactcta aggaaagcaa ttgaattagg 96660 tagttgaact ctatagtaga ttttctttaa tgagtccttt tgttctcaac ctacttaaat 96720 aattctcatt tgaatttatg atagtttcag atctacccaa agggtgactt aggaatttaa 96780 cttctaaatc tatttaaatg aaaggtttat aatctttttg tcatatttta cagtcgttag 96840 cgtttaacaa tttatagcat aggatttggg tttttttttt tttttcattt taaagaagaa 96900 gtttatttaa gcaagacact tgactaaggg aagactatct tggagttatt attactagag 96960 taatttattt ctacttaaag acagattgcc ccacaagtaa cagctacata aaaacagttg 97020 taaaattgtc cttggtttta caatgataaa tgaaaaacat taaaattctc taattgaaca 97080 aggtatgcaa ggatttttat attgtttttt gctaaaacta tgacagcaaa ataacatcct 97140 ggagtataaa gataagagct gaatgagcag gccactaggg gacaaaggga gtcttttcac 97200 agaaccaatg cttcttttgc ccaccccatc tccatcgaag tcaatctaaa catattattg 97260 gccatttagt taaaaaaaga aagaaaagaa aagcaatatg cttgtggaca tacaccagtt 97320 actttatgtg cagtaaaaga gtaggaaggg gaaggtgaaa gaatagagaa aactatgtag 97380 tcaggatgtg gtggaaccaa attgcaactt tctttttttt tgagacagag ttttgctctt 97440 gtcacccagg ctggagtgta gtggtggccc aatcttggct cactgcaacc tccgcctctc 97500 agattcaagc cattctcctg cctcagcctt ctgagtagct gggattacag gtgcatgcca 97560 ccatgcctgg ctaatttttg tatttttagt agagatgggt tttcaccatg ttggccaggc 97620 tggtcttgaa tgcctgactt caagtgatcc acccgcctca gcctcccaaa gtgctgggat 97680 tacaggcgtg agccactgcg cctggccaaa ttgtagcttt ctaattgaga ctgtcttctt 97740 ggtctggaag agcagagttc tgcagtaaaa taacaggtcc cccttttagt agacatctcc 97800 atgtctgctg ctggaacaca tcagttttgt cttaagcctc acttccaaat gtgcagatgt 97860 gtctggttca ttgattggct gcctgtcaaa ttgaaacctg atctgcctca ttggcaaacc 97920 gtgcccctta caataggctt tcattggttt actaagcggt gtggtgcgtg gctgttcatc 97980 ttaaactgca ccacagttta agatgaacct tcaaatgaac attatccttg ttctcagtct 98040 tgactttcct tgggcttttt gtggaccctg gtgagtgtgg cagtctcctc agctgctgct 98100 tcacaaaaga ggtaccaggt ctgccccgaa tgagtgagcc cctaaacagg accaggagtg 98160 gcagaagaaa gaggcagcaa ctgagatgtg ttttttctaa gctgaaaggc tttttttttt 98220 tttttttttg caacacacct ttaacactaa agtccaatat ttatataatt ggtcaagtaa 98280 gtggagctgt tctagctata aatatggcaa ctctgcttgc tcgtcctatt attgacatta 98340 ttcctttctg tggtctgagg tgcctcccat gaaacttgct tctaggacac taggattgag 98400 aaccatcagc gtaacatatc tgttacgcta caatagttta ttttcatatt ttagctactt 98460 tacatactcg ggtataatga actttattca tagcttctga agcagttggc acatttgaga 98520 tattttttac ttggctaatt gttatgctaa atcttttgat ttctaaagat acatgccttt 98580 gctaagcttt cttcaaatgt tattattttt atttagattg gatcattgct attccatgga 98640 tgactcagag gatacatcct gggactttgg tccacaagca tttaagcttt tgtctgctgt 98700 ggacatctta ggcgaaaaat ttggaattgg gcttccaatt ttatttctcc gaggatctgt 98760 aagtatatat ctgtgaattc ccttcataga tcttctttta cttctattac acttttcttc 98820 agaggtttgc agtattatga ttgtagcttt gacttcagat gggtgactag gaactcatag 98880 agtcttacta agttccagtt aaacactaca ttcattactt tggataaaac ccgtgtgtat 98940 ggcatcttct gctgttttca tgttcaagcc gatgttcagc tctgcagctc agtctggaag 99000 cattgtgtta atttatcaca ttgcatttgg gtgaatccct agactagtct tgcttaggat 99060 aattaggaaa agttaacttt cattgtatca agggacaggt agaacaaaat tgtccttttg 99120 tccaggaaac cattaaattc ttcaaggaaa actttagtta tagggattat tttttaaatg 99180 tctaatttca gtaacaatat ttgggacata tttatttttc cttctgtttc ctatcagaag 99240 tatttaaagt tataagaaaa ttgtggtttt tgcctttact aatgaataaa taatcaatta 99300 aattcagtta cttttttttg gagtgattga tgttccagta ttcttctaaa caaccacggg 99360 tacaaatgtg aataagatag gaccgttgca gtccaagagc ttgttctgta gtcctttcct 99420 ttatatgatt ttttcccctg atttagaagt ctataaagca aagctaagta ttacacactg 99480 ataatggctg aataaatcaa gagcaagaga taggatactt tgcaaatatg catatttatt 99540 aaaaatgtac tttaaaatag agattaaaat tctcgtattg aatgtagaat aggtaagcat 99600 ttatttgtga aatactcgaa tgcttcatgt aaatactttc tgagtttgta tttttagaaa 99660 ggaacatttt ggaggctgag gcaggagaat ggcgtgaacg tgggaggcgg agcttgcagt 99720 gagctgagat tgtgccactg cactccagcc tgcgcgacag agcaagattc tgtctcaata 99780 aaaaaaaaaa aagaaacata tttattaaat tagttgtgaa atatttttaa tgaaatatat 99840 tgaaaacttc tgttgatttt tcatgtactg atgtttttag attctaaatg gagtttaaaa 99900 ttttgtttgt aaatcacaag ttggattaga aatttaatag tagaagtgtt gcctaaggac 99960 tattttaggt gctgtgagtg aaactgtatt ttttataaca agaattttag ttgtaaggga 100020 cagcttaaat ataattgaga tctgtgaaaa tgtattctgt ctctatcacc ttcagaacct 100080 gtgtatctca gttgaatgta taatttataa aaattattct tgttttaatt tggtgtaatc 100140 cagccatatc cagtatcaac aaataagtct aagtaggctc cttgacaaac ttgaactggc 100200 cacaagagag atcagatttc acctattaaa aaaccaaatc agaccactta cactgacagt 100260 ctcttctggg agtcctcaaa ttaagaagtc tatcctttgt gaaatattac actacccttg 100320 ctagataaaa cttttctaaa agtaccactt aatgaaaatc tgtagacact aaatgcaatg 100380 aaaataaggc attgtttttt tttctcccca tttcagtgat cttggtatcc tgggatattg 100440 tttttaaaat tatcgttata attcctttga gaatttagtg aaatgttccc tttaaccaac 100500 ttaggaaaaa ttaatatctt tgtacatgat tttgagctgt aaaataaaca ttttaaactg 100560 ggaataattg gagtttagtt aaagagataa tgtatataaa tatataacat agtagcagca 100620 tataattctg tcttacacaa gatttttctg aatagtataa acagttatgt agcctatcta 100680 ggagtttgtg aatagagttt aaaattttgt tttgaagctg caaatttgat tagaaattaa 100740 acagtgaagt tattacttaa ggaacttcgt tttagctgtc tgaacaactt actgtataaa 100800 aatctttaaa cattctgtat aaatatgtga taagatatgc aatgacctta attttataga 100860 ttagaaaata aaaacacact cattaattta cataactgac agattaagtg aaacttctct 100920 tctgatcacg ttagcagaat gccaaatctt gtcgtggcac tagaattaga cggtagtttt 100980 gataatacat gatttgacta tagacatttg ttgaaactat tggtagtttt aatcactctt 101040 gtaattttca aactatctaa cgggagagga ttatccatcc tgttttctag acaaactgtt 101100 tcatctgaat gaaatatatt cctagagata attatcacta cttcatcttt tggttttatt 101160 ttgcacatag aattatagtt cacaatgact ttctgaagct ctaaagttgc agctgtgagc 101220 ttctttggcc tgtagggact gggaaaaagc acccccgtcc tcccccaagc ccccccacca 101280 aaaaaagtta aagtgttttt aacaatagct gtgggctttt tgtagtttca gaacttagga 101340 gttgcccagg ctggaatgca gtggtgtgat catagcttga tgcagccttg aactcctggg 101400 ttcaagcaat cctcccacct cagcctccag agtagctggg accacaggtg ccaccccacc 101460 cagctatttt ttttattttt taattttttt gtaggtatgg ggtctcccca tgttgccctg 101520 cctgtctcaa actccagggc tctcaggtga tacccaccac ccttggcctc ccaaagcacc 101580 gagagtcact gtgccaggct gagtttaaaa tttcttgagt tggagtttat ggctattttt 101640 tccactagtt attaaacatg tatttttgta taaggcactg tattacattt tgtgggggga 101700 ttcaaagcta aattagatga gacgcatcat ctattatgga agatgttact taagaagaaa 101760 tgagtgtaat gtagcagaga attagataag ggacgtatga atacatataa atgctgttga 101820 agttctgaag agagagagtg tttagagaaa ttagaggagt ctttgtgaag gtatcactag 101880 aacttcctat ttttgtggaa tatatagtag attttggtgt gatactgtgg atttggacat 101940 tcactcagag aaggaatgag ggaagaatgg tggagaagaa tggcattcac agtacaaaaa 102000 gcaactgtga cttttaaaga agttaatatg gagaagtggc aagtcttttc ttctctcttc 102060 tcttctcttc tctcttcttt ttcttttttc tttttttctc tgtcagatac cgttgtaaag 102120 actttgcttt taccggaaac tgatacgttg ggtcatgtac cctggccagt cagttctctt 102180 tattctaaca cttagccgat cagttagatt tccacattcc atgatatgtc agttttggtg 102240 acccttattt ttccacctgg tttataaagg gaaagaatgt gatatgtcac ccaggctctg 102300 gagtacagtg gcatgatcat aggtcacagc agcctcaaag tttccagttc aagcgatcct 102360 acttccttgg cttcctgagt atgtggcact acaggtgcat gccaccatgc ccagctaact 102420 tttttgtaga gacagggtct ccctatgttt cccaggctgg tcttgaaccc ctgacctcaa 102480 gtgatccgcc caccttggct tcccaagata ttggcattac aggcatgagc cactgtgccg 102540 gcctgaaaat ttctcttttg agatggcatc ccacagaagt atacctgctt agagctaaca 102600 ctggtaaaaa gactatttaa ccctattgcc ttattttact gtagttgaga ttgagttaaa 102660 ctgaaagctg aatgacctgt cctaggtcat actgttactt tgtgccagag tcaggatgag 102720 caaatggatt tcctgcctgc tagtctagtg tcttttctat ttattgtgct gtaacataca 102780 gttttaaatt tgtattttta tgcccaatgg acatggtagc tcacacctgt aatttcagca 102840 cttttgggaa gccgaggtgg ggggattgct cgagaccagg agttcaagat gagcctgggc 102900 aacatagcga gactccgtct ctataaaaaa aaatttaaaa attagctgag tggtgatgtg 102960 tgtgcgtgta gtcctccttg tgggaggttg aggtgggagg atcgattgaa tctaggaatt 103020 caggactgca gtgagccatg attacaccac tgcactccag cctgggtgac agagcaatac 103080 cctgtctcga atgaatgaat gaatgaatga atgaatgaat gaatgcccaa atccgtaagc 103140 tatgttctgt atagcagctt tttcatcata ggcagttttt actcttatca gtggacaacc 103200 tacaaaatta actaaacact taaacaatta acagaggagg ccttgttcag agtgagaaat 103260 cattaagcat ttgttgttga aatttcttac tgtactctgt tttaattctg tttttttttt 103320 tttttaatgt tacttgtttt agtttggatt cctagttgaa aagggaatat gattccttta 103380 aaacaaagat actctgcttt aaagcaaagg tatatcatcc tcttcatggt gattgccatg 103440 gaaacaagac aatgtaaatt tattcaaata gtacacagtt tttatagtta ttgatcatga 103500 ggggaaggga cagttaatcc ctactgatca gataaaacct cattgtttca tactaataaa 103560 tggttttttt atgcttatga aaggaaaagc cagaagtgta atttttagtg tttagagagc 103620 tagtgattct agttagggaa cttaatacct ttgaagttat tagtttgcaa gcaatagaat 103680 ctactactac caaggtgacc cctagcagat gtagagtacc attaacaagt gttccaggga 103740 aggaaagcca actagatacc aagtcatgct ttttactctt agattaagaa attcaggttg 103800 agttaaagga tcagctgtta actaataaaa agcagattaa tattacagag ccaggctctg 103860 tcctggttat ggacttaatc ttcacagcat cctcaagaga taaaaatgaa tatacctgca 103920 tattagatga ggaaatagaa gataagtaac ttgccagagc tatgacgtga actcaggtaa 103980 tgtagcttaa gagcccccac atgtatgtat attgggtgtg tgtgtggagg gggtgcgtgt 104040 gagtgcttgt gcatgcgtgt ggtataataa gaaaaaatta gcatttatgc ctgtaatccc 104100 agcactttgg gagaccgagg cacgaggatc tctcaacccc aggagttcaa gaccagtcta 104160 ggcaacatag cgagacccta cctctacaaa aaaagtttta aaaatattag cgggcatggt 104220 ggaatacacc tgtagtctca gctgcttggg acgctgaggt gggaggatcc ttgagtccag 104280 gagattgagg ctacagtgag ctatgatgac acctctgcac tccagcttgg gtgacaaaga 104340 gagaccctgt ctccaaaaaa aaaaattaga actagttatc tggaggcctg tgttctagtc 104400 ctagctttag tacggctaca cagtgacaca ttaggctacc atttaacatc tttgaacctc 104460 tgataatttg ttaacaatat gggtaaaaat gactaagata aatcaaagag ctccagcatt 104520 ccctccagct ctgaaattct atgatgtttt atcttatttt acttacaaaa ataaattata 104580 ttatgtatat ttaaagtata caatttgatg ttatgggtta cctatagtaa aatgattact 104640 ataatgaaac taattaacat atccatcatc ttatattgtt aaccattttt ttgtttttgt 104700 ggcaaaagca gctgaaatcc actcatttag caggaatccc aaatacagtt cagttgtatt 104760 aattgtaatt ctcatgttgt acattcgatc tctagacttg tttatgctac atatgtttga 104820 cttttaaaca ttctactcaa atcaacccta agtcagggtt agcacagaca ggacttgtta 104880 acaaggtaga aggtgccaca ttgtacctgg gtgtttatat ttctctaaat cttgttctga 104940 tcatatttta ataaatataa tcatcaggac accaaaattc attccttagc tattaaaaaa 105000 ttctattcta ttttattgtt aagatttagg agagcatggt acagattctc ttaactatac 105060 ctatcagaag cctatgtttt aagtccaatg tataggcact gctctgtttg tctctggtgg 105120 gaacttaccc tgctttacct aatttcatcc tagcttcctt tttgtgaaag atcacccttg 105180 cttagcctat tttttggcaa atctacacct tggaaatagt agtaaatgac ataagcatat 105240 taatatttat gatgtgattt atttttgttt tcaagtcata tactggggaa gattctcaaa 105300 tattaaaaca atgtatcttt acatttatgt atgtcgttct tgttctgttt tagaaggctt 105360 gtatttgcat ttttaacatt ccaaaaggta aacctgtaat cataatgttt tcatcaattc 105420 aataaaacca ttacgtttgt aatagagagc cctatagttg ccttagttaa gtttgctgca 105480 actcatttta tatattcttt taattttgat ccctggattt ttaattgatt attaaacctt 105540 cattaggata tatatgaaat gtaaaaatat tgagttataa tctaccgttt tctaaaattt 105600 tatactgcat ttttatatag aaattcaaat tgctcataat cattctagtg aatttaagta 105660 gaaaggtatt tattactagg tattaaatgg cttataatat tgttgacaag gttccactgc 105720 aaaatagttc accaagggag ctgtggcctc ttctgtgatc aagaagccat ctgtcaactt 105780 gggaagcttc cactatagca cctaacccca gactacattg agtaggaagc tgtaataatc 105840 aggaagcttc tacctttgca tgctctgcaa accaacgtga acctgctgta atttgtaacc 105900 acaaaatgga tgcctgttga tacttacgaa gctcatcatt gtatgctggg ttctttgcta 105960 atactttctt ataaaaatta aatacctcca caatcatgca tgctagcaga aacagcagag 106020 gagtagcctt agcctcactt cctgcttata cctgtcatgc aaatatacag aacccagaac 106080 cctagctgaa agggagtttg agaactagta tttgtattgt cccagattct gcagtggaag 106140 aattcatagt ggatggaagt tagaatgacc cttgaattac aatcggccac attcatcaca 106200 aatacattaa ataagagtaa tttgccataa agctctatgt ttgtatactt ctttgttttt 106260 tttttttttt tttttttttt tttttgagac agggtctcac tctgttgctc agtctgtagt 106320 gcagtggtgt catcatagct cactgcagtc ttgatctcct gagctcaaac gattctcctg 106380 cctcagctcc tgcttcagcc tcctgagtag cggaacaaca ggtacacacc accacacttt 106440 gctaattttt tattttttat tttttgtaga gatgtgggtc tcactgtgtt gcccaggatg 106500 gtctcgaact cctgggctta agtgatcctc ccaaagtgtt gggattacag gcatgaacca 106560 ctgtgcctgg cccatatact acatatattt aaaagtagta tttaaatgtg taggatgaat 106620 gaaagaggca gtaagagaac aaagtgaatg aaaaagtatt tctatatgaa gtgaaagcag 106680 gagagtcctc tctgttagag aacaacagaa ttgcatatga cagactagct ttcttaatat 106740 ttctagaact tgatggctgt gaagagcgtc ccgtaggaat tctcccttca cttaggaaaa 106800 catacctcaa aaccatcagc tgtttagcat gcacctgctt ttcctggtat atctcagtga 106860 agcagctaaa ttgtaaatga ttaagtaaac tttgcagtgt atcatgtgca aaagcacagt 106920 aaaaacaaaa atgcattgga agctgtgagt tgttgcactg cactcatgga tgaatagctg 106980 ttggttcgca ttgcgttttt ttgttttgtt ttgttttgtt tttttgagat ggagtcttgc 107040 tctgttgccc aggctggagt gcagtggcgt gatctcggct cactgcaagc tctgcctccc 107100 agattcacgc catcctcctg cctcagcctc ccgagcagct gggaccacag gtgcccgcca 107160 caacacctgg ctaatttttt gtatttttag tagagacggg gtttcaccat gttagccatg 107220 atggtctcaa tctcctgacc tcgtgatctg cctgccttgg cctcccaaag tgctaggatt 107280 acaggcatgc cgcattgcgt tttatataat tctcatggtt ctagtctcga gctgtaggat 107340 tttgatcact gtttcaaaca ataatgtgag tttgctaaga ggtctaaata acaaaagcta 107400 agtgttccaa acacatatcc aaacctatac actgggcaat gcatctgaat tatatgtgaa 107460 atttcctgcc attatttaag acacaaaagg aacattattt tgataatgta tttatttgtg 107520 agtggagtgt tcagaatgag cacgatgggt ataacatttt tgtaggtttt taaagttgaa 107580 atttagtgta aatccaaaga atcaatagac aagtctgtgt tttacttaac ctatatgttt 107640 aaattagcat ttttagatac tgattttatt cctaatttca gaattctcag cgtcttgccg 107700 atcaatatcg caggcacagt ttatttggca ctggcaagga tcaaacagag agttggtgga 107760 aggctttttc ccgtcagctg atcactgagg gattcttggt agaagtttct cggtataaca 107820 aatttatgaa gatttgcgcc cttacgaaaa aggtaaacgg tgtaggagtc tgcctgtttg 107880 acttaatttt gtttcccact ccacattaaa agatcctttt tgcttttaat agggtagaaa 107940 ttggcttcat aaagctaata cagaatctca gagcctcatc cttcaagcta atgaagaatt 108000 gtgtccaaag aagttgcttc tgcctaggtt catttttcag tttttttctt gtaacttctg 108060 cattttttgt tgctatttat gtgattcaaa ttataccagt ttataggcct ctcacaagta 108120 aaatgaatta cctgtttgtt tttgtatgcc tattttagtc agtttggggg aagggatctg 108180 tgaggaaagg ataagtcata gagcactttt cttttttaag agacagagtc tctctgtgtt 108240 gctcaagctg gagtgcagtg gtgcgatcat agcttactgc agcctcgatc tcgtgggccc 108300 aagtaatcct cagccacctg agtagatggg actacagaca tgcactacta tgcccagcta 108360 atatatttta attttttgta tagagacagg gtcttctagt gcttcctagg ctggtcttga 108420 actcctgagc tcaagtgatc ctcctgcctc agcctcccaa actactggga ttacaggcat 108480 gatccaccgc tcccagccag aacattttct tggttgatgg gaagtagctg accatggtat 108540 ttagaaaact tctttctcat cgattaaaga agcagtactg aaatcaatgc ggaggaatcc 108600 atatatcata tttacttctg gtgtgtagaa gtggaaaggg aatacatttg ttgcttactt 108660 ttttgtacct ttacatgtga ttgatcactt gtgagttttt tctttcaaac atcttaaagc 108720 ttccagagct ttttctagaa aaaaaaatca gttttaagaa tcaccagttc taaaagggta 108780 atatcttatt catctttctg agaatggagt atcatgattc atgaattaga tacttgcatc 108840 ttaacatttg aaataattta attttattat tttttagttc gaaaactgta tcttcgggca 108900 ccaaagagca ttgttataat caagtaccag ttgaattaag tacagagaag aaggtttgtt 108960 ttaaagaaat tgttctgatt tatttcattc tttattgatt caaattctgt ttaaaatttt 109020 atattttaat tcctttccaa ttaaagagaa aatggcatat ataacaaagc ataaaattcg 109080 gccagggaag tgatgtgaac agactaaaat ttattgtata taatttctgg ggctaataaa 109140 gaattggagg tatttgagaa aggaattaat ttgggttctt ttaaacctat ctgctaactc 109200 atttggctta gagtagtcac atgttataat acttatagtt gatcaaaaaa ttgattccta 109260 agtgttctta ttaaagacac acacacacac acacacacac acacacattc tctctctctc 109320 tctctcacac acacacacat gcacacacac ttatgtactt tcttgctttt tttgacctaa 109380 gatcttagat aactattaca gattaaatac taatccactg gcagacttca gctaattaga 109440 acactggaat aataggcaag catagtgaat tacattttct ggtgaacttt ttctgcttta 109500 ttgaagtatg cagaatgtaa atgaattgtt tttataactt tggcacttgc tgtatcttag 109560 aacattcttt tgatgattta ttttctgtag ttttgggaga gataagacat tggaatgcgt 109620 ttctaactac ctttagaact ttagaaactg ataatttagg aggttatttt caggtgatta 109680 atttgacagc ttgattaggc aaagaaaaaa ttgtgatttt gagatttttg tttcttattt 109740 tcttcacatt taaaagtttt ttgaaacttt ttttaatgga cctttatatg tttaaatgca 109800 gtctaacttg gagaagttat attcttataa accatgtgat aagatttctt ctgggagtaa 109860 catttctaaa aaaaggtaca gagttccata tttctatgtt ctatacttgc tttatgagta 109920 cttttttttc taaagagaaa gaactgtcag atgttgggct atttcattgg caaaaggaag 109980 ttaaatttaa aacataagct tttcagtatt agaatgatca aagtgagcta taaaagaata 110040 atgttaattt aatagctaac acttcttgga tattactgtt tgtcaggcat tatgttaaat 110100 gctaagaact ttatatgtga tatctcattt aattcttaca agagtctaac agctgttact 110160 atttatcgcc attttatagt tgaagatacc aagggttaag aagttgacaa acttgttcaa 110220 gagcatacag ctaatggccg agctggcttt caagtctata tttgtctacc tctagcatca 110280 agacactatt tatttttctt tgtatgaaat atatacaggc atactttgtt ttattgtgcc 110340 tggctttatt gtgacttgca gatattgcat ttcttataaa ttgaaggttt gtggcaaccc 110400 tgcgtcaaac aggtcatatt agccccattt tccaatagca tgttctgttg tcatgtcttt 110460 gtgttatatt ttggtagttc ttgactggcc attcaccatt tctctccctc tcctcgggtc 110520 tccctgttcc ctgagataca acaaaattga aattaggcca attaataact ctataatagt 110580 ctctaagtgt gttttttttt ttttcgagac tgagtctcac tctgttgttc aggctggagt 110640 gcagtagcac aatctcggct cactgcaatc ttcgcctccc gggttcaagc gattctcctg 110700 tcttagcctc ctgagtagct gggactacag gcgccccccg atcatgtctg gctaattttt 110760 gtatttttag tagagatggg tttttgccgt gttggtcagg tggatcttga actcctgaac 110820 tcaggtgatc cgcctgcctt ggcctcccaa agtgctggga ttacaggtgt gagccgctgt 110880 gcctggccca tctctaagtg tttaagagaa aggaagattc acatgtctct caatttaaat 110940 caaaagctaa aagtgattag gcttagtgag gaagccatgt cgaaagctga gataggccaa 111000 aagctaggcc ccttgcacca aacagttagt ttgcaaaggc aaaagttcct gaaggaaatt 111060 aaaaatgcta ccccagtgaa taaaacaatg ataagaaagc aaagcaggct ttttgctgat 111120 atggagaaag ttttagtggt ctttatagga gattaaacca gccacaacat tcccttgagc 111180 caaagcctaa tccagagcaa agccctaact ctcttcaatt ctctgaaagc tgagagaggt 111240 gaggaagctg cagaataaaa gtttgaggcc agcagaggtt ggttcatgag gtttaaggaa 111300 agaagccatc tccataacat aaaagtgcaa agtgaaacag caagtgctgg tatagaagct 111360 gtagcaagtt atccagaaga tctagctaag atcatcgatg aaggtgcctg cactaacaga 111420 ctttgaatgt agaccaaatg ctttctacca gaagaagaag ctgtctagta ctttcatagc 111480 tagagagaag tcaatgcctg gcttcaaagc ttcaaaggac aagctgactc tcttgttaga 111540 agctgatgca gctggtgact ttaagttgaa gccagtgctc aattagcatt ctgaaaatcc 111600 tagggccctt aagaattatg ctatatctac tctgcctttg ctacatacat gtaacaacaa 111660 agtcttgatg atacctgttt acagcatggt ttcctgaata ctttaagccc attgttgaaa 111720 cctgcttaga caaaagattc ctttcaaaat gttattgctc attgacaaca cttagtcacc 111780 aagagccgta atggagacat acaaggagac taacgttgtt ttcatgcctg ctcgcttaac 111840 atccattctg tagctcatgg atcaagaagt aaattaacct tttaagtatt attatttaag 111900 aaatacagtt tgtaatgctt tagcttctgt agatagtgat tatcagagat gggtttttaa 111960 gaggttttcc agaaaacctt ctggaaaata ttcactattc tagaagtcat gaagaatatt 112020 tgtgattcag gagagtaggt cagaatatca atattaatag gaatttggaa gaagtcgatt 112080 cttattaaaa tcaagagttt agtgatagac atactgagtt tgggatacct gtggagtagt 112140 ccagaagtta atttaaatat atgggcttag tgtacagaag tgagcagggt gcttatatat 112200 gaataaatat tattttaaga tatatttaaa ttttccttaa aataatacct atacttgata 112260 taaaaagtta attggaaatt agtggcttat gacaagcata ccagcccaca ctcttcccaa 112320 acccactttg ctcttattca tagaagctgt catcttcaaa tcttccagct gatttccctg 112380 gcgtgtgcct tcttatttct gaatgacacg cttagagtac tatttttttg acttagcaat 112440 tttagaaatt ttctactcat ctcctattat ggtagatttc ccctccttca ttcctcctcc 112500 aatataatta tatttcgtca tattaataat ttgtttatat atatttttaa tataatatga 112560 taatattgta tttatattat taaaactaca caaatattat atacacacta ctaacccaac 112620 cgtgttatta tggccaccac tacctttatt tttttccttg tgttagtgat tgtctttgtt 112680 ttattttctt ggttttgagt attcctttta ctaattttct tttttcctat ttcaatctct 112740 cattatttgt ttactcattt ggagtgttcc ttgactttta tcccctctta cctagtgaca 112800 ttttaatttt agttatcaaa tttttaattt ctaagaatgc ttcttgttct cttcttgttt 112860 cttcttcccc accagccaaa aatctatgat gttatagcaa ggatcataca ttgtttccca 112920 gtaggttaag aaaccttggt taaaacctgt tgtatcccag taagttaaaa gacgttaacg 112980 tgtcatcttc agtatggatg aaagaatatt ttctttcaaa agcagttggt tgaggaagag 113040 aatgggacaa atgctctttt taaaacacca attttgtgat gaactcaaat tgcaatttta 113100 actttaccat tataatgaat gtatttgatc caaaatgttt aaaatctagg ctgttgtcat 113160 ttaaataaca aattacctta ctggtatcat gaagaataaa tgtttgtact gatttggaaa 113220 gacattctca tttaggggat gaaatagaaa gtcaatgagg agaaagaaaa gcttttatta 113280 tttattttct tttaaatatt ttagtatcat ggtacagtca ccagaaaaag cttacagttc 113340 ctcacagcct gttatttcgg cacaagagca ggagactcag gtaaggcttt tgtaaaaagg 113400 taattagttt atgataggat agttatgatt ctatgtatgc ttaaaattct gtattttgcc 113460 agcattttaa aaattgttct taagctaaga gtctgagttt atatttcagt ttatattcat 113520 tctaaggaaa aatgtggtat ctgaagctct aaaaataaag gactagatct tttaagtaca 113580 ctttaaaaag tgttgtttct ttgttttttg ttcagattgt gttatatggc aaattggtag 113640 aagctaggca gaaacatgcc aataaaatgg atgttccccc agctattctg gcaacaaaca 113700 agatactggt ggatatggcc aaaatgaggt aaactatctt ttgcatgtgt tctatttatt 113760 tccttctaac aaaatagatt tggaaaatat atctaagttg ataatatgac catagcttcc 113820 actgtcacat ctgggaggtg actcagattc cccctgctgc gatgcttatc tctttgccaa 113880 gctttagtac cgtgtttctg tatgaataaa aaccagttac gttttcagca atcatattca 113940 atatttataa aatctaactc attatttacc caccctgcat tttatccaaa tgccgaaact 114000 cctctttttg gattctttat ttttgattat cttaccatca catttgtagt cagaggttcc 114060 taatgcttaa aacctctgat ctgaattttc tctcctccaa tataaaaccc cttcgtcttc 114120 ctcttcttct tcttcatttt tttttttttt tttgtctgaa gacttgtctc actgtgttgc 114180 ccaggctgga gtgtagtggt gcgatcactg ctcactgcag ccttgacccc ctggactcaa 114240 gctatcctcg cacctcagcc tcccgagtag ctgggactac agaacatgcc accatgctca 114300 gctaattttt gtattttttg tagagacagg gttttgccat attgcctagg ctggtcttga 114360 actcctaagc tcaagcaatc ttcccgcctc agtctccaaa gttctggcac tacaggtgtg 114420 agccactgtg cctggcctct ttttctcatt taaatacttt tcataccttt tgtaaaacgg 114480 gttccttgtt gcctgtctat gccttcctcc tccttcttaa tgacaccacg ttaattctga 114540 ctgttttccc ttggcctgtt gcagaagcct cttaactatt aacccttcat tctctctctc 114600 tgtttcatct gatatatgag taccaaacta aatcttcctt tatcatatct tacttctgct 114660 taaatgtttt ttttctagct tagaattcaa ggccctctat ttatgaactt aaacttactt 114720 ttccctctaa gttacagaat ttgaaatggt ttatcttacc tggattgttt atcacttgtt 114780 gaagatccat tttcaacttc catatattta tttacagtgt tgcttctcct tgtagtttcc 114840 ttgattcctc aaaactcctt ttaagaattc ttgaagatct cgctttatta ctatttctcg 114900 ctttattact gtaaagacta tgagaaggtc tttcatgatc ttatcagcaa agtaattcct 114960 ctctcttgaa ttcatagagg actttcagat gaattctaaa gatgcttctg tagcacttac 115020 cacacaatgc tatattttat ttttttgtaa ttagtggtaa acaagtatta ttatatcttc 115080 tagattttaa actccaaata aagatactag ctccttacct ttttgtgtgt ctcctgtagc 115140 acctagcaca atgcctcata aacaggaggt gatcattaaa tatttagaag aaattatttc 115200 ccaagaatag ttgcttggta attgtatttg tcttttactt ccttttaaaa aattgtttct 115260 gtcactaaat tgcatccaat agatgttact tgagtgcaga attttctaat gacattacac 115320 agtgctacat ctgacactaa ttcttttgtt aaaaaataaa tattctggcc gggcgctgtg 115380 gctcacgctt gtaaatccca ggactttggg aggccgaggc gggcggatca cgaggttagg 115440 agatcgaggc catcctggct aacacggtga aaccccgttt ctactaaaaa tacaaaaaat 115500 tagccgggcg tggtggcggg tgcctgtagt cccagttact ctggcggctg aggcaggaga 115560 atggcgtgaa cccgggaggc ggagcttgca gtgagcggag atcgcgccac tgcactccag 115620 cctgggtgac agagcgagac tccgtctaaa aaaaaaataa aaaataaaaa taaataaata 115680 ttctaagacc atactttaat agaggtgttt tttttttttt tttttttttt tttttttttt 115740 tttggtgata gagtctcact ctgtcaccta ggctagagtg cagtggcgcg atctcggctc 115800 actgcaacct ccgcctcctg ggttcaagca attctcctgc ctcagcctcc ggaatagctg 115860 ggactacagg tgcgcgctgc cacccccggc taattttttg tattttagta gagatgaggt 115920 ttcactgtgt tgtccaggct ggtgttgaac tcctgagctc aggcaatcca cccgccccgg 115980 cctcccaaat tgttgggatt acaggcgtga gccacagtgc ctggcccaga ggagatattt 116040 aatgaaaaat aataatcatt agataggcag atttttagaa ggagggcatc gaatgggttc 116100 ttggatattg gacacaataa gaaatattga gctaaaagtc tgaaggaatt ggcagatata 116160 ctgttacagg taaacacttt gtagaagaaa ataatgaatg agactttctt ttgagatttt 116220 cttagcctct tagttgttcc cagttaaagc ctcatatttt tccttttcat gacaataaaa 116280 ataataataa aatcagtaat aaagtgaata tatgagatgt taacctgttc ctttatgaca 116340 atgtcctgtt taccaattaa cagtgtgttt ttgtggtgat gggggcaaga caaatcttta 116400 aatggtggaa agcaaagaaa gaaattataa aacatgatta gttgtattat acgttgtttt 116460 tggttgttgg aaaaactata catttattga gagaatcatt aggaagctga acatcagcta 116520 tattgctgga gtgatactgt ttcagtggtt tcttgacctt tttgttgttg ttgttgttgt 116580 tgttaaacac agaccaacta cggttgaaaa cgtaaaaagg attgatggtg tttctgaagg 116640 caaagctgcc atgttggccc ctctgttgga agtcatcaaa catttctgcc aaacaaatag 116700 tgttcaggta aaatactgtg gtttgcagga gctcttagag aataagcatt ttttgtaacc 116760 atttcaaaag taccctccag aagcaacatt tgctcacttt atttgcattt ccatactgga 116820 cacttagaaa atgaattaaa attgttttta cagtcaatct gttgtaaaaa catgtcagtt 116880 atctactttt aaagatgata ctaaaaagta gttgtccagg ctgctgatgt ctttctattt 116940 cattgggagg ttttgttttt aaattggaaa cattatttta ggttgataaa ttataatttt 117000 acattcaaat gtggtagttg gaatttaaag ctggaaagtt atccttgcta tgagttggtc 117060 aggagctcag ccactttctt ttggtttagc atcttctcta atctccctcc ccttccagta 117120 atgctgtctt ttgatagtaa gtggatttca tattattctc ttcagtttta atagtgtttc 117180 cttcatatcc ttttattatt gcttgttctg ccctaagtga ccatttccag aaatgtcatt 117240 taggattttc tctaaactcc acgtagcaga ctctataatg catactctgc agaaggtgag 117300 gcagtgggag gtagagggga gactactaga ctaggagtca cggaatcagg actttagttc 117360 ttccttacag ttgttcacct ggtgaacctg cacatgtcct ttaatttcct tgggtctcca 117420 tttcctcagc tatacaatgg aaatgacact tcctccccca catccaggaa acaacagatg 117480 acattagaaa atagaagaca tgggataagt ataaaatgtt gaaagagtta aacacattca 117540 aggcaatatt aagggattat tttttacttc caagaagctc ctggaagctt tgggcaggca 117600 cagttggatc ctactttaga aaaatctttc tctaactata agtagaaaac ccttctgctt 117660 tttgaatgta gcatttccct cttttgatat agagtatctt tggcaacttt gaattttctt 117720 tttcatactc ttatataaga catcatgtga aaattcttat ttcttactga gtttttggaa 117780 atgaaattat aatgtcttaa tagtttgaga aagaatatca tacctaccag cggtaattga 117840 gtaagttccc tctctttgga cacttgaaag tagtatcttc tttcatgaat tagtgatatt 117900 atttaataat gaatgagtga tctctcctaa ctccccttca gaagaggaaa atgaagtagg 117960 ggaaaaggta aattccccaa gggataggta tgaaaccttt atgaaccttc tggatagaga 118020 agatgactgc tgatttctgt gattagaaat tatacttggg ttattctgca aattgaaatg 118080 aattatttaa aaaaaaacaa ctttaatgtt tattaagcaa gttttgttat tcatgagttt 118140 cattagcctt ttattttttt tttaaatttt gaagtaaaat ttcttgctgt cacaatacac 118200 attaaaaatt acaaatatga cacatattaa acacattaag atggccgaat aggaaaaata 118260 tgctaaaata tttttatata aatacatttt ttgagaattt tgagaatttc tggaacaaag 118320 taatgatata atccataaat gtacaattaa agagtttaag gatatccaaa atacttggca 118380 aagtaatctg aaataatact cttaggaagg tagggcaaga atgtgattct agtaagcaaa 118440 aatgtgatca aatcgtattc tagtcccagc tactcgggag gctgaggcag gagaatggcg 118500 tgaacctggg aggcggagct tggagtaagc cgagatcgtg ccactgcact ccagcctggg 118560 cgacagagcg agactccatc tcaaaaaaaa aaaaagacta tatgaacatg tatggcataa 118620 atatgtacaa atattattta ttttaaaaaa attcaggggt agggacaggg tagttagaaa 118680 atatctaagg atgttcatga aataatactg gctatgaatg acagttgatg aaaccgggtg 118740 gtgcccatct tattccctcg actcgtgtat atgtttgata tatcccacaa taaaccttaa 118800 aaaaaaaaag atgagtggtc aattatagga agatataaat agaaaaggca ataaggacaa 118860 aagttggcaa agcttaccta agcactcttc agataaaaag acatttttgc taactagatt 118920 tgaatattat agtttaattg tcaaggaaaa tgcctcaact taatctttgt taagagacta 118980 cttaaggcac tatcagaagt tccctcatgg caaggtgcaa tccctcatgc ctgtaatccc 119040 agcactttgg gaggccaagg caggcaggtt acctgaggcc aggagttaga aaacaacctg 119100 ggaaacatag tgagacccga cctctacaaa aacaatttct taaaattagc caggcatggt 119160 ggtgctagcc tgtaatccca gctatttagg atgcttaggc aggaggattg cttgagcccg 119220 gggatttgag gctgcagtga gccatcattg tgccacaata ctccagcctg agtgatagaa 119280 aaaaaaaaaa aaagtgtctt tgttatattc caaacttgtt ctcaactttc aggtgagctg 119340 gcttcctgta taactcttgt ataggacaga acatactggt tggggcaagt gaaactgtct 119400 agttgtatgc ctcataaatt aatgaatttc ctttctaata tatacactga tatttataca 119460 cacatacaca taaaaccaag ctcaatagat gggtagtgca gctctattcc ccaaaaccca 119520 actaccctgt aacaagacac attagacttt tgagattgca aggatgagga ctgaaatgct 119580 ggcctagacc atggtgttgc catagtgggg tgaccagtct gaatagccaa caatgcttcc 119640 tcagtaaata cccattttgt cttggtggga tttctataaa ttgcaaaatg cagctattat 119700 gaagctgtaa aagagaaaca gaaacatgta acacctggga ctgttttatt aggcccaccg 119760 tatgctcaga acatgaaatc tccactgcta gggttatttg attgaaatta tcttttgtgt 119820 tgatgtgaga gtttagctct gagattcttc cacatgtaaa atgtaatccc ccaaagtatt 119880 tggcaagcac attttattgc cttgggtcag ataattgaaa cattaggcat catatatata 119940 gcatgtaaaa agtaaaacag aaacatttat gtttctcacc aagcagtaaa ttagtactca 120000 actaataaat ttcttaaact ccctaataac agaatatgga aacaaaaaat aaatctttcc 120060 aaaagaagag ctcatggaca catttcctca tatatgtata cataatatag tagaacacat 120120 gataaataac ctataaaaat gataccaata tcattcatca agagacgagg ctcttcttta 120180 aattattaat ttcatctgtt acaggtttta ttatgactgt agtatgctgt tttcatctac 120240 cttttatgtg tagttaaaaa aatagttttc tatctcttta cctttatttc agcctttaaa 120300 aagattccat tattttttca ttaatcttgt ttttcagttt ttcccatttt ttcttttaaa 120360 catttcttaa ggaaccatat ttaagatttt atagaatact tagatttcta gttgggatgt 120420 atcatttaaa attagatatg tagagagagt gttatgatat atttccttac gatatattag 120480 tggttatagt acctaaattt gaatagtgat tctgttcatt cattcattca ttcattcaat 120540 attcacttcc aggagattgg ggacttattt aaagacagag tagttcacat tatagttcct 120600 ttttttagtc cttcttattc gttaaagaaa agactaggaa atgtttgtta ttacaaatat 120660 tttattaaaa ttttgtgtgc tctagcatta ttttaccttt taaaatcaat atgttaaaaa 120720 tccaacttct ttttgagctc cccataaaaa gggaattatt tgttgcttat gggtttaact 120780 tgtgttattt ttttcttaat ggctaattat catacatata ttctattatt gtattgatat 120840 tactgatcat ttgtgctaca ttaaaaattc tgtagacaga cctcttttca agtacaaaac 120900 ctcaagaaga acagaagacg agtctggtag caaaaaataa aatatgcaca ctttcacagt 120960 ctatggccat cacatactct ttattccaag aaaagaagat gcctttggta agtgtgactt 121020 tcatgttaca gggaattttt ttagtttact taaacttgtg ttttatcagc tttttagtat 121080 taaagttctg acttgggatc aatttcctcc aaccctacaa taaatctcag tttatcttta 121140 attttaaaag agaatgttgt tttctttttc tgttaagcct ccctgttaag taatagcagc 121200 aagtttagtt tggccatgaa tatcttctag agattgtatc ggggtactga taaacacatt 121260 tgtagctcag ggatactgca tcagccatat tttaaaatgg gactaacagt ttaaaaacta 121320 taaatattca cagtgttaag aaacaatctc aagatgcatt aagaaaaagg aaggtgcaaa 121380 acagaaaaac aaacgtaaac gtgtgtgcat atgcatgctt atatagtcac atattcttgt 121440 atgtgtacaa aaaatacaca ctggatctct gcaagcatag ccaagcaact ggaaatatgt 121500 ttttaaaaac ttgcttttca ttctatctct tctagtactg ttttgatgct ctttgaaaac 121560 aatctaattg ctgtaacaaa tgaccatacg taggccgggt gtggtggctc atgcctgtaa 121620 tcccagcact tcgggaggct gaggcaggca gatcatttga ggccagggat ttgagaccag 121680 ttggacaaca tagggagacc ctgtctttac taaaaataca aaaattagct gggcgtagtg 121740 acgcatgcct gtaatcccag atacttggga ggcggagaca tgggacttgc atgaacccag 121800 gaggcagagg ttgcagtgag ctgagattgc gacactgcat tccaacctgg gcgaccgagc 121860 aagactcggt ctccaaaaaa aaaaaaaaaa aagaccatat gtaatgtttc ttcattgttc 121920 taagataaat ctttaaggct gttgaggttt tttgtataca aaatggagag taagttttaa 121980 tgggatggga caaaatgagg cttacagttg agtttaattt gagttcacat cctgttgaca 122040 ttaagttgat ttggaacaag tgatatggtc caatgcctgc ttttctattg tctgtggttc 122100 catccactag tgcctgtgtt acacacctct tgttcaggtt ttatcattta aaataaataa 122160 gaataaacag tccatagctt atcttactta ctgaataaat gctctaattt gacagtcatg 122220 tttcttaaag ttccttacaa aggccattgc ccaagaaacc aaataattcc attatactat 122280 ttttgaaata gaacacataa taaatgggaa ttttaagttc agtttcttat gtaaacaata 122340 acttctatgt acatgttaaa tatgcctgta tatacctaat ttgaccatgt atgtatagta 122400 gaaatgaaaa cagttactaa gaaaatttgt tattggctcc aaattttctg aattaagtgt 122460 attctaatgc tcagccataa tatggggttt catgtgttag tttatgtatt catggttaaa 122520 aatgtgaaga ctgttatatc ttcatttgtg tcttttggta ttatttggtt gtattttatt 122580 gtgtgatatg gtggtataat tatccttacc tcccaggagt ttgagagggt cttgccagtt 122640 aaccgcagaa ttaaacatgc ttaggactaa ttaatcagga gcaatactac aattagttgg 122700 aggtaatttg aaacctggtt tcaaataacc ctgatattat gcacacatgg tgcacacttt 122760 tctagtagac atttaatgaa agtaatttaa aacctacctt tgaaggatga aaaacattgc 122820 cttaaatgct ctattctgtg aaagtatcaa catttatgca aatacagtct aaattcagac 122880 tttgaaaatg tattgaaaga gaggatcatg aaataagtta gagctgagtg acaaagcttt 122940 ctgagtgttt aaaagaatgt tttacctaat aaatatctga aatgtatttg gagccacatt 123000 tgtttaaaga actgtataaa tatgtagcac tgttcatgtg aagttcaata gtaggaaaat 123060 gctgacagcc cttgtggaac tgtggttatt attattttat gaatagagcc aatttcaaac 123120 acctattaga gtcttctcag gaacatttta tagaatgcat ctggagcctt atgttatctc 123180 taagcatttt aggatttgtc ttcttggaaa ttcatgtaac caaaccacca tgtgttattt 123240 caagtgtata tagtattggg ttacagttta ctatgttttc agaaggttgt gacaactatt 123300 agacttacag agaatgactt ctctgccact aacggctttc taaagtgaat agagaggggc 123360 gaggattgaa ttcttcggta aagctgggtg attttgtttt attcaataca gtataataag 123420 tataaaaagt agaacctata gagagctata atgggggtag ttttaaagaa attctgaaaa 123480 tgaaaaactt aagtaaaggt ttagttcatt gtttatttca cactgagcat ttactacctg 123540 aatgttttgg acattttatt tccatgactg gagtggacac ttttacaact cactgggttc 123600 tttgctgatc tttctctaga agagcatagc tgagagcagg attctgcctc tcatgacaat 123660 tggcatgcac ttatcccaag cggtgaaagc tggctgcccc cttgatttgg agcgagcagg 123720 cctgactcca gaggttcaga agattattgc tgatgttatc cgaaaccctc ccgtcaactc 123780 aggtgagagg catggcctag ctctgcaccc ttaatgactt gatgaagtaa acaagcaatc 123840 cactatattt ttcactgtta acagcattaa tcctttatgc tattatgaaa accttacttt 123900 tgtgattctt tttcttgttt taggaaaaca atctttcttc ccattatcac tcagaggaaa 123960 gtatactgag aaattttttt gttttgtttt gttttttgag acagagtctt gctctcttgt 124020 ctaggctgga gtgcagtggc gtgatcttgg ctcgctgcaa cctctatctc ccaggttcaa 124080 gtgattctct tgcctcagct tcctgagtag ctgggactac aggcgtgtgc caccatgccc 124140 agctattttt tgtatttttt gatagagaca gggttttcca tgttggctag gcaggtctcg 124200 aactcctgac ctctgatgat ccgcccacct cagcctccca aagtgctgcg attacaggtg 124260 tgagccatgg cacctggcca atacactgag aaatttttat tttccttttc agcttaaggt 124320 tacaacttcc ccaccatcca aaacgtgcac tttcattttt tttctaattt ctatctcatc 124380 acttgcaaaa accatatttt tctccacatt cattcccagt agcttcctga ctcctagttc 124440 ttccctaaat ccttctgagt ccttgtcatt ggtttcgctt gagtagcctt tctaatcaac 124500 acagtcattg gtatcagtta ctgtgacatg gaagggacag accaagttct gtgggccgct 124560 acgtagaagg atttcctgtc actttgctgc agaacctcag ctcgcggaga gcaagcccct 124620 ttgcttgccc tgtagaaata ttttaaatta ttatcctttt tttttttaac agaagtaaat 124680 aggagatacg ttagaggatt ttctctccta gatgtgtaaa tacaaacttg gggtcttata 124740 actcaataaa tctgataaat ttcttttgac tgttaggata gagcagtggc cataccaata 124800 gcctcatctc caaagctgca gtgaagatac tttttactac cttaaagtct ttcccatttg 124860 tgaacaactt gtgaacaatt ccccccaaga atttggaaga tcactctctg aaagcacagt 124920 caatactgta cttaaatgga tctgagcaaa aataagtcac ttagaagaca ggattatttc 124980 tagacttgag tgtgacttga ctgaaggtct aaagaacaaa cagctccttc acttccattg 125040 atcacggtgg aagcacaggg aaaggacaga cacggaggca agttggagta gtgctcatct 125100 aagttccagg gatgcggggg agtggccagg ggacttcagg tatagtaaat aaataaccta 125160 tttataagtt atgtcaatgt catgtttgaa atagaaaacc aaatactgca tgttcttact 125220 tacaagcagg agctaaagtt ggtgcatatg gatataaaaa tgagaacagg ccgggcgtgg 125280 tggcttgtgt ctgtaatccc agcactttgg gagacctaga tggaaggatt gcttgagctc 125340 aggagttcaa gaccagcctg agcaacatag tgtgaccccc atctctacaa aaaataagaa 125400 aattagccag acgtggtggc atatacctat agtctcagct acttgggagt ctgagtcagg 125460 aggagtgctt gagctcagga gtttggggtt ataataagct gtgatcatgc cactgtgctc 125520 cagcctgagt gacacccaga gtgagaacct gtctcaaaag gagaaaaaaa aaaaagtaac 125580 agtagacgct ggggactact gaggggaggg aaggaacaat ggttgaaaag gtgggaaggg 125640 acagtggttg aaaaactacg tgttgggtac tatgctcact atctgggtga tgggatcaat 125700 tgtacctcaa acctcagcat cctgcaatat actaatgtta caaacctgcc catgtactac 125760 ctgaatctaa agtaaaagtt ataatttaaa aaaattataa taaaatcaga aaataaaggt 125820 ctgagatgga aaattaaaag accaaagcca cccataagca caataaatcc ctccccccaa 125880 aaaattatat ctattaaaaa aaggtgttgc gccaggcact gtggctcatg cctataatcc 125940 tagcactttg ggaggccaag acgggcagat gacttgactt gaggtcagga gttcaagacc 126000 agcctggcca acatggtgaa accctgtctc tactgaaaat acaaaaatta gccagcagtg 126060 gtggcatgcg cctgtaatcc cagctactca ggagactgag gcaggagaat cgcttgaact 126120 ggggaggcgg aggttgcagt gagccgagat catgccactg cacttcagcc tgggtgacag 126180 agtgagactc tgtctcaaaa aaaaaaaaaa aaaaagacct tgtaccctga caagttttag 126240 tttgtgcagg aatgctagaa tgactcaaga ttggaaaaat ctttaaatgt taattacaca 126300 ataagggtaa aaggagaaaa attacctaat gtcatctgag caacaagaag aagaaatgaa 126360 aggcattaaa aattgggaaa aatttatatt tgacagtatc ttaacaacga attctgcttc 126420 tatatcactt cctagctttc tgatgataac ttcccgtgca gatctgtatg taaggaatgg 126480 acgtagtagt catgctaatc tgagtattta tctgtgtgat acttacgaat taacgatgta 126540 agttaataag ttagcatttc gtgaacctgg ttaataccat ttgctaaggt taaattagcc 126600 aaatcctgaa gtaagctgta aaacatccaa ggtagggtag agaggcatct tatgagaaag 126660 ctggccaact ctcctggtca ccttctaatc ttcctaactt cagaaatcaa ggcagagaga 126720 ggaaaatagt aattactttg taggattaga tttatggttg tcgaaacctt tgtttctcca 126780 gtgcagaatg agatagcgtt ttagggaaag ccaaagactc agatgtcttc ttcatgctca 126840 tcgtgtggaa tttttcttcc tttagaaatg tattgtctct cagggcttaa agcaatttgc 126900 atctttcgat gagacattga gtaataggca atattctctg aaataatttg tgcaggctgg 126960 gcacagtggc tcacacctgt aatcccagca ctttgggagg ccgaggcggg caggtcactg 127020 aggtcaggtg ttggagacga gcctgaccaa catggtgaaa ccccgtctct actaaaaata 127080 ccaaaattag ctgggcttgg tggcacacac ctgtaatccc agctacttgg gaggctgagg 127140 caggagaatt gcttgaaccc ccatgggagg tggaggttgt ggtgagccaa gattgtgtca 127200 ttgtactaca gtctggacaa cagagtgaga ctctgtctca aaaaaaaaaa aatagaattt 127260 gtgcagttcc ccccaccccc tttttttttt ctgttggcat ttttgctatc atttagctgc 127320 cttctttata tcctgaaact tacaggtggt gttggtctag tcagtaagag caaaggcttt 127380 gggaatagat agatctgtat ttagaccttg gctctagcat ctcattgtta tgtgacctcc 127440 atcaagtgac ctaatttccc taatattcaa tttcctcatc tctaagacag ggagttaata 127500 ttgcctctct tatagaattg tgagaaatat agtcatgtgt cgcttgatga tggggatgaa 127560 ttctgagaaa tgtgttgttg ggcgatttca ttttgtggga acctcacagg gtggacttaa 127620 acaaacctag atggtatggc ctactacaca cctaggctgt acggtatagc tcctgtcttc 127680 aaacctgtac agcatgtgac tttactgaac actgtaggca attataacac agtggtattt 127740 gtatatataa acatagtgaa acatagaaaa ggcccagtag aaatacagtg taaaagattt 127800 tttaaaaaag ctgggcatgg tggctcacgc ctgtaatccc agcactttgg gaggccgagg 127860 caggcagatc acttgaggtc aggagttcaa gaccagcctg gccaacatga tgaaactccg 127920 tttctactaa aagtacaaaa attagctggg cgtggtgttg ggtgcctgta atcccagcta 127980 ctcaggaggc tgaggcagga gaattgcttg aacccaggag gtggaggttg cagtgagtca 128040 agattgtgcc actgcacttc agcctgggag acagagcgag actctgtctc aaaaaaaaaa 128100 aaaaaaaaga gataaaaagg tacatctgta cagggcactt accacgaatg gagcttgcac 128160 cctgggagtt gctctgggta agtcagtgag tgagcggtga gtgaatgtga agacctagga 128220 ctgtgcactg ctgtagactt tataaaccct gtgcacttag gccacactca cccctgtgat 128280 acgagtctac ctactgtata acgtacctgc atatgtaccc ttgaaactaa aacaaaagtt 128340 aaaaaattta tcttcttttg ccaataataa attaacctta gcttactgta atgattcttc 128400 tttatgaatt aaaatctttt tactcttttg taataacact tggcttaaaa cacaaacata 128460 ttgtacagct atacaaatat attttcttta tatccttctt ctctaagatt ttttctgttt 128520 ttgattttgt taaatttgtt tttacttttt acattttttt tgttaaaaac caagacaaaa 128580 acccacacat cagcctaggc ctacatgggc tcaggatcat cagtctcact atcttccacc 128640 tccacatctt gtcccaccag gtcttcaggg gcagtcatat gcatggggct gtcatctcct 128700 gtgataacaa tgccttcttc tggacacctc cagaagggcc tgcgtgtttt acagtgaact 128760 tctaaaaaat aataaaatgt atagtatagc aaacacataa acatagtaac atagtcattt 128820 attatcattt tcaagtatta tatactgtac ataattgtac atgctagact tttacacagc 128880 tggcagcaag gtgagtttgt ttacaccatt accaccacaa acacatgggt gatgctttgc 128940 attgtgatgt tacgatggca tgatgtcact aggtggtagg aacttttcag ctccatgata 129000 atctaatgga tacttgttcc tgttggctgc ccgtcgttga ctgcaacatc attatgtggt 129060 gcatgactgt aaattagata ctgttcagaa agctttggca cactggtaat agcaaatggt 129120 ggtggcaaat atgatgatga tgatgatgat gattgaagac atagatggta aaattttatg 129180 gtgtcttaaa agtaccctct aaatatgatt atttttatag tctgtccttt tgaataggca 129240 cttaagaatg tatgaactta ataagtatat aagaaagaat gttccccaaa atatatctta 129300 cagaggcata caatttaaga attcaaacag gttgtaatgg ggtgtgtgtg tgtgtgcaca 129360 cgcgcacgca tgcgtgctca ttcacactaa agaattcttg ggcatatgtt cctgaatgtc 129420 ctaaatggac attctaacat cacttcatta tgggcagagg gaaatggtaa agaaaaattt 129480 catattatat tattcagcca catattgaca gcatctgttt tatttgccta tggtaaagaa 129540 ttgaagcact gttaatttgc tttttaaatc atgtaggcac aaagttatcg aactttagat 129600 ttagaaatga aactggaaat cattacactt tccctttcct atccccaccc tgttttggag 129660 agaaagagtg tgaggcttag agagttataa aactgtttta ataccatgtc taagattaat 129720 aactgaacaa gtttctcttt ttactcgtgt taaagttgta ctgccaatta acttaaaaga 129780 aagaaatatg caatttctaa tcctgatata ggatatgggt atataaactc taacttgatg 129840 agtgaaacaa attaacttat ttataatcag tttcatatct ttatttattg agtgtcttta 129900 aatacccctt acctttaaag taagaaatat taaaatcaag cagaatataa taatgaaaaa 129960 ttcttaagat atacttacta aaaacttatc cttcggttaa tacactgtat gtaggttgta 130020 catacaatat gaaaaagtat atttttgtag cctactttta aatccagaat agaggaggtt 130080 aagaaggttg tgataaccat gagctctttt tttttttttt ttgagacaag gtcttactct 130140 gtttcccagg ctggagtgcc gtggcacaat catagcttac tgcagccttg aactcttggg 130200 ctcaagcaag ccttccactt cagccttcca agtagctggg accacacctg gctaattttt 130260 aagtattttt gtagagatga gttctcacta cattgcccag gctagtcttg aacccctagc 130320 cttaagcgat cctcccacct cagcctgcct aagtgctggg attacaggtg tgagccactg 130380 agcccagccc tcttttattt cttttgatag tacactcata atcattaaac tatcatttct 130440 ggatgtgaga ttgtgctttt ggattcttat tttttcttta taaaatactt tttgttctct 130500 tactggagaa aacattgttg gattataaat gatataacaa ggaatgagga tatacatact 130560 ataataacga ttcagatatg ttattttcat attttattta actgtagcca tgccacaata 130620 atttagagtt ttaaagaaca agtttgattg aaatctaaac tttgtacaat cctgaattga 130680 gaagtttcct gtattttatt atgacacaat atttacctaa aaatagagta attatgaatt 130740 gagaaaacat agctattaat ttcatactct tatttgttaa gtagattttg tctggaaaac 130800 tgttcatatt taaaggagct ttgtaccttt gtattctttt tgtttttcct tgtttatata 130860 attttaaact ctgtttatgg atttgggatt ctaactatgc taaataataa attaaggcat 130920 tgaatgaagt acctagacag tattttgatt aattttattc ccccattctt aatgtgcatg 130980 taactggaaa attaagagtg gcttccaagg gatctactac aaaagtaagg ttaatatgat 131040 ctcttttaaa acactgaagg cgtgtagcca gtgttgtcat taattctgca gtagatattt 131100 tcagcactta tttacatggg aagttagagc agagtaagat gcacctgtaa agctaaatgc 131160 cacttatttg catatatata aaacgcagga tgaatttacc atagaaatat aaagggtact 131220 tatagaaatg tattagaaaa atatatgaat ttttaactta tatctagaag ttaactttat 131280 acatttaact ttaaatcatt aatagtggtt taacaccata agcggatgtt tatgcatcat 131340 cattttatga acaaaagaca ttctaatttt agaaataaag tgattcaaaa gagaataaaa 131400 tatcttactt tttcttttaa aattaatttg tttagcgcat tacatgataa tagctcaagc 131460 ttgtgtgatt tttccctaaa aaattggttt ataaatatta catttatagt atgaagaaat 131520 taatcataca tagtttattt atctaatttc taaataccca tggaagaaaa tgaatttaat 131580 ggaatgtagt tgtgtattac ttggtttcga gtgtgggaaa atttatatgg tctttctaaa 131640 acagcactgt cagtagaaat acaatgtgag ctacatatgc aattttaaat tttctagtag 131700 ccacatttta aaaagtaaat ggatgcaatt tattttgata atataattta attagtctac 131760 tatatttaaa attttatcat ttcaacatgt aatcaatatg aaaattatta atgagatatt 131820 ttacatactt ttttctgtaa taagcctttg taatcaggta tgtactttat atatacaaca 131880 aatcttctga tgctaaattt taactggaaa tacttgatct gtgtttagct tttgtaaaat 131940 ttactgttga acaacgtgga ctaatgtgcc taagtggttc caaacatatt ttaaaatttg 132000 aagacaaata aaagggaact caaagtaaat tgggatacat acatacaaca gaatactgag 132060 ccattaaaaa atgatgaaat agtaaaattg ggggaatttt gatgatacta ggatgatata 132120 atgaccaaga gacaaataca attttagttt ggttgagaga tgtgatcatc acgttgctga 132180 ttttactatg tatagaggtt atcttttcct ttctaagatt ttgaaacttt aattagttaa 132240 cccacttacc tagtttctat tagctgtgta actttctctt cctgtttttt gttttgtttt 132300 gttttgtttt ttgcttttta actgcagtat tttgaggagt cttggagtag caagctaatc 132360 tttggaagaa aggaaaatat aaacctgaaa actaacaatt taaagaacgt cttttcaggt 132420 tgtcatttga aaaatacttg atttctgatc actgatttga attgagtgtc aaatatttga 132480 tatgttttgt aaattaggtg aagatgagtg agtaggttct aaactgcttg ggtttaccgc 132540 actctggagc attgcagaag aatgtgatgt tggaaggaag tgctgaaaca taattattgg 132600 cttgcctata ggagggtgct acataatttt agaaggtgtc aagaaattga cacagtctga 132660 attagttctg ttgagttgca aaaaatgtaa agtttcttga ttctgaaaat aagaaatatg 132720 ttcccagaaa tctcatctag ttaatgtgct tttaaaatca ttgatgtctc ttgttattac 132780 aataatagcc attgaaagaa tcttttttat tagaatgtta tttacaggta cgattagctt 132840 ctatttaaat aaattatttt tatacttgat cttaggcaaa aggccaacaa gtgatcagaa 132900 taaattattt taagagaaaa ctaattataa ttgatatttg gaattggaag cacaatttcc 132960 tttagaacaa ttccacgaat ggttgttttg attctcaagg cagcccacaa aagacagttt 133020 gaaacacaat ttatgcagtg tcaatagtac tgacctgact ttggatcttg gaggcagggg 133080 cttcaggtga tacccgagtg gagtttttac tccatttcca ttccgtaagg ctataggcat 133140 ttgaaagagg aaacttttct ttggcaacct tccaccttcc tttctacaga atatttcagt 133200 atttctagct cataggtttt ctaaaatatt ctctgtaatt tattttgaaa tggagttttt 133260 ttatcgttta cagatatgag taaaattagc ctaatcagaa tgttagttcc tgaaaacatt 133320 gacacgtacc ttatccacat ggcaattgag atccttaaac atggtcctga cagcggactt 133380 caaccttcat gtgatgtcaa caaaaggaga tgttttcccg gttctgaaga gatctgttca 133440 agttctaaga gaagcaagga agaagtaggc atcaatactg aggtattaat tatatataga 133500 attttcataa agtgtcagtt tgttcaattt gcatatccta gtactagaat gctgtatttt 133560 tttgaactgt tatgaattct gatatgatta ctttctctat gtgctacatt tcctttgctt 133620 ttcataaata tgatctgaga aaagtgatta aaaaaaagac agtaaaaggg aggtttagtc 133680 catctgttta gcttattatg tagaatgtca gcttaaattt tacctgtacc tcatattgac 133740 cgtatagcct ggaaaatctt tcggaggtat agttaatgga tttaagcata tggcagttta 133800 tgtagttaat gaaagtgaaa acaaattgta ttataaatac ctcccaaact ggtttattat 133860 cattctatca ttcttcatgc tctgttagta tgatattgaa tatctgaggt accaggatta 133920 ttgttgcttg tggctctgag catttcgtag tgcttttgca tgatgagaga aagattacaa 133980 atttagtatt atgttagatg gtacgtttta ttaaaatcaa atgcttcaaa aataattgct 134040 ctgtgtatgg catgagataa atagcaatca gatatattgt ttaataatat gactctatta 134100 aatgatggca taaatttgaa aatttgacct tcggtatctt ccgggtctaa aattatatga 134160 ctccattata aatattttgg aaatgattaa ctaaaaaatt gtttcaattc ttagttggta 134220 aattcaatgt ggtagtaggt ggtggtgatt attttgtatt agagaattag gaattacact 134280 tagttctaag gtaatcttta taggatgtcc agcaattaaa cccctacttt tttgaattgc 134340 ttaaaaataa gggaactgat ctttttaaat tctgtacttg agttacgtct gtatatatag 134400 tcatgtccta gataatctaa tggaacttaa ttagttggaa atctttatat tgtttataac 134460 tgaactagct ataagaggaa cattaaagaa aacatatttt gagtggaggt aatgaaattt 134520 agcttctaat gctcagcctt ttatttctgt aatctatacc agatacctaa gaccctctta 134580 ttgtttccca gcttcaacct gtcagtatag aaaacggtgt aacttactat tttttctcaa 134640 tattgaagca catttgtagt gaaatattat tttaactata tattgccatt tttgcttttt 134700 ccctatttca gtaacatttt tcgctatttc agtaacatta catgtcaaca agagaatggt 134760 gggtattttg gggggggttg ggtggggaga aattttacta agcttgctag attctaaaag 134820 gtatacctta tttggcccct tttccccatt taggggaaca agggtgttgg ggctgggaag 134880 tagataagag gtgagtaagt catccaaagc atatgtcttc attagcctcc ctgtatgaaa 134940 agctgatttc tgtagagtgt tggaggccta ctttcagaat ctgtcatatg ttaacattca 135000 tcttctctac tgacctgatt tatatccctt agtctatttc attttataat tatgacaaag 135060 gataaagtca ttagaacaaa ttctttttat tagttgacgt attgttgtgt ttatatctct 135120 tgtgtttgtt attaagatgg aagctcaatc atgtccttgt ttaacagaaa ggtgatgtct 135180 tggcattgat aattctgatt caatatccat aggtacatgg tggattcttt aaatatttag 135240 tattctttta tttctggaaa gttttcttaa atgatagttt ttttaaaatt tcatttctat 135300 aaagttttct taaatcatac tttttagtgt tttattccat tacttcatat ttcttcttca 135360 ggaactcctg ctatacatgt atgttggatc ttcattaccc agcttcaata tttttcactt 135420 ttcatgcatt ctttttattt cttcatttct ctttaaattt ttttcttcct tttcaccttc 135480 tatttctctt ttaacataat tgtatttatt tctgtattcc acatagctta gtattcactt 135540 attttaaaat tattttaaaa cgttttttag atttaaaaat tcttttttta tttatatata 135600 catattttat ttttaccaaa ggagcaacac tattaactga agacttctat aatttttttc 135660 ttttatttct gattctttct tcggttttcc ccctcagttt tgaacttttc taattttgat 135720 ttgtgatgtc cttttgtatt ttagataatt ttcctaatgt tttccagctc atttggaaag 135780 gctacagttt tattctgtac ctaagcaagt ctttctggtg tcaaagattt gaccttgata 135840 cttttctttt gctcattttc gtatgagatt agttttcctg tactttcaaa agaaggcgtg 135900 gttcaagatg gctttcccaa tttcacatct gtctctaatg tttttgtgta atgtctaaaa 135960 tatggaaact tggtttatga gatctactct gccattttta tctgggcttt ctcttccttt 136020 tgtctctgtt gtacctgtcc tgcttggttt tgatttaacc ccagtggttt ctcctgaatg 136080 tggagccttc tcctagaagg cagcctcggc tagtcccagg gttcagagta gccagctgct 136140 ctcttcacct aagagaccac tgtggattcc ttgtactcac ttgctattgg cttggacaaa 136200 agccctccca ttttcagatg ctattatcag attaatctct cattaatctg tctttccagt 136260 gtatgcctgt gggctatctt ggggttctct tgttatcaga cacctccctg ctggcctctg 136320 ctttctcccg tacagatgtc agtactgtgc aggtcttaat tgctgttggt ggtttgcccc 136380 tacattctta cagttttagt ttcccaagga tacctttaaa cttggtttta ttgtaaatgt 136440 cgacaatgga ttttgggttt tactatctag ttctgtctta attctggaat tcagaaagat 136500 taaaagctct gttgttgcag ctgctgccac ctcttcccag taccctctcc tcctatgtca 136560 tttttttctt cttatttttc ttgactgtat aagagagaat gtatgacatt tcctgcttga 136620 ccgctgagtt tgattataaa ttaaaataca caatatttta tacaaattgt tttgtagaag 136680 atttatttac agatgctcat tcacaggtaa aattgactta tgaaaatagt tttcatgaca 136740 aatgtatcag gctcggtaac taaatatatg gattgatctt gtttataaat gaaattaaat 136800 gtgaatgtaa cttacatatt tctgtatttg cttacatccg tatgtacaca tataatcagc 136860 aaatgagttg atgtttccta ttcgtaactt aatggtaata gcttggtaac agagttggga 136920 gtattaaaaa gatgtaaaga gccccttaaa attttgttgc tgggaatttt agtgttctac 136980 tgatgaagga aatagacact ggaaggcgtt gtttctatta ggtaacttag atatcatact 137040 gaagacttca aatacttatt gttgacactc aaaagacaca cttagtgtaa gtaagcattt 137100 ccccgctttt cccaatgaaa taagatcatt attataattc cattataaat gctgatgatc 137160 atatttatag aaatatagaa gataagactt gaaatgatat tcgctaccaa ttaatgagtt 137220 tgaagaagaa atcaggatgt gttttgctat tttacattta ttcttattta actccaaaga 137280 attcagtgat gttatgtact attatttcca tttctctgtg aagacgttga agcttaagta 137340 acacgcataa taaggtcata catttagcaa gtggctcaat taaagttcaa acctggttct 137400 gcctggtttc aaagtctgtg ctactccatg gtattaggct acaacatgac ttagggtttc 137460 ttcctctgct ctattgctgt tcagatgtac tcctcttttg gcagagtggg agaaaatttt 137520 tgcaatctat gcatctgaca aaggcccaat atccagaatc tacaaggaac ctaaacaaat 137580 ttacaagaaa aaaaaaaaaa cattaaaaag tgggcaaagg acttgatcag acacatctca 137640 aaagaagaca tttatgtagc caacaaacat atgaagaaaa gctcaacatc actgatcatt 137700 agaaagatgc aaaatgcctt ttctgtatgc caccttatat ccccagtatt tattatttct 137760 aagtcatagt atcttacagt gtatataagt ctcatccgtt cttttgattt tctcttccct 137820 gcttgcaatt gggtacctag gaacaaagtt gcaatcttag ccagtttttt ctttagcctt 137880 tgctgatgtg tgaaaagccc ttttttctac cctggatttc tgtacttaag ctggaacagc 137940 taagttttta ccttttttaa atataaagtt tcagagtctt ctgccaagga tcttttgctg 138000 ttttcctact gttaaatatt tcaaagcctt ttttaaacat agggaatata atcaaacata 138060 gcaagcagct gatgaacaat atctagatag tcttcattat tgaaatggaa taaatggtat 138120 ttttgtattt taggctaaca gacaccttgt accttagata aggccaacct tctcataaaa 138180 tccctcagtt acttttatta ataataacca aattaactct ggattccagg gtgtactcat 138240 gatggaatga tttctctgtc atgttatcct gaggatctag tactctgaga taacataagt 138300 gtatgacact ttaggcttat gaaacactta gctacttaaa ttatttaatt ttttttcatg 138360 tgcagatggt attgtaccca aacactacct ttgtgtgtgt gtgtgtgtgt gcctgtgtgt 138420 gtgtttttga gacagggtct tactctgctc aggctggagt gcagtggcgt gattatagct 138480 cactacagcc ttgacctcct gggctccagt gatcctgcca aagtgttggg attgcaggcg 138540 tgagccacct cacccagcct taaattattt ttttttcaag gatgtttaac ctgagggtta 138600 gaggctcttt ggcacgtgag ctgctgaaat gtgtgtgaaa gtgttgtgca cgtgtatgtt 138660 tctctttttt tctgggaagt ggatctgtag tgattcttag atgagtctat gagacaagaa 138720 acttttattt ttttcattta tttagcgaat gtttgttaag cgtactatgc cttggccact 138780 ctacagggtg ctgattggac cagtctgtct acctaccgtt gtagatgtta gaagctatat 138840 tcttttcaca tgcctaatat aactctttgt gtatgtatac atgcccaggc atgttccttc 138900 ctcagaacat taaattcacc attttggtca actcaaagca agtacaccat gggacacaga 138960 tctgaaataa tgtccagatt tttacttact gaatgaggtg tgttgagtgt ataagactac 139020 atgatgagat ggcaagtaat tgcctgaaga aatgatgtag tgattttgtg tgtcttatat 139080 ttatttactt tttgatccag aaataaatta tatagatacc actattttgt ttggatgggg 139140 gagaaaggat gggtgtgtat tcaggaactt atgttacttt tttgcaacta ataccccttc 139200 tcagtagtac aaagatttga tttctttttc tttctatttc ctacagactt catctgcaga 139260 gagaaagaga cgattacctg tgtggtttgc caaaggaagt gataccagca agaaattaat 139320 ggacaaaacg aaaaggggag gtctttttag ttaagctggc aattaccaga acaattatgt 139380 ttcttgctgt attataagag gatagctata ttttatttct gaagagtaag gagtagtatt 139440 ttggcttaaa aatcattcta attacaaagt tcactgttta ttgaagaact ggcatcttaa 139500 atcagccttc cgcaattcat gtagtttctg ggtcttctgg gagcctacgt gagtacatca 139560 cctaacagaa tattaaatta gacttcctgt aagattgctt taagaaactg ttactgtcct 139620 gttttctaat ctctttatta aaacagtgta tttggaaaat gttatgtgct ctgatttgat 139680 atagataaca gattagtagt tacatggtaa ttatgtgata taaaatattc atatattatc 139740 aaaattctgt tttgtaaatg taagaaagca tagttatttt acaaattgtt tttactgtct 139800 tttgaagaag ttcttaaata cgttgttaaa tggtattagt tgaccagggc agtgaaaatg 139860 aaaccgcatt ttgggtgcca ttaaataggg aaaaaacatg taaaaaatgt aaaatggaga 139920 ccaattgcac taggcaagtg tatattttgt attttatata caatttctat tatttttcaa 139980 gtaataaaac aatgtttttc atactgaata ttatatatat attttttagc tttcatttac 140040 ttaattattt taagtacctt tatttttcca ggatgtcaga atttgattct aatctctctt 140100 atgtagcaca tgtgacttaa tttaaaacct atactgtgac acagagttgg gtaaacgatg 140160 attatttaac tttaagcagt tcaccatcca tttcaaagcc tttgattggc ttttttgtaa 140220 ataaaaataa cttgttaaga aacaaatata tctgtcatag aagaactaga aaatccaggg 140280 aagtgagaaa aatgaaaata aaaatcattc atagttttac tagtagctaa tcacagtcaa 140340 cctcttttgt gtatcccacc agactttttt atattcattt gtttttagtt aaaatataaa 140400 agtctcgtat attcccattt ttctgcattg cattaccaga aggtagtggc gcctattaaa 140460 tatgtgatat gttgttgtcc agccatggct tctgcatttg catgcttttg tgtgtgcatc 140520 tgcaataccc tgtgaatatc ctgtgtgatg gagtggcaag tacgcacaga cacgtctgct 140580 gcatgcctag gtacgaggct gtctccagga gaagcacttg tttgattatt tgagttgcca 140640 attgaatttg ctgctttttt tcatggcttg ccattttcac tgaaaagaat gactaatgaa 140700 aaacgatgat tggttattag atttggatgt ttggcagaca ttttctcaaa attgaactaa 140760 gttggcctct tcacggaaaa caactggtat ttgttgtgcc aatgataaaa ttggagattt 140820 ctagcaaaat gtataatttt ggaaaagttg tgttcctcca ctggaagctt gacagctttc 140880 cttaacataa agacttctct ttctcttcgc tttcactact actactacta attcttcttc 140940 tgattcttct tcttctcctt cttccttctt ccttccttcc tcctcctcct ccttcttctt 141000 cctcttcctc ttcttctttc tctctttcct tccttccctt cccttcccct tccttccttc 141060 cttccttcct tcctccctcc ctccctccct ccctccctcc ctcctttctt tttctttctc 141120 tttctttctt tctttctctc tctctctctc tttctttctt tttctttctc tttttctttc 141180 tttcaagcag tcctcccgcc tcagtccccc aaaatagtgg gattacaggt gtgagccacc 141240 atgcacagcc ttacataaag ccttttctaa tgagatggat agtaattaac aaatgtgagt 141300 ttttgatatt atataaagat tttttctgtg tttcgaagat ccgtataact cagtgaatca 141360 gtatgttctg gatgactaat atgtgatgtt aagaaatcat gactgaggcc gggcgcggtg 141420 gctcacgcct gtaatcccag cactttggga ggccgaggcg ggcggatcac gagatcagga 141480 gatcgagacc accctggcca acatggtgaa accccgtctc tactaaaaat acaaaaatta 141540 gctgggtgtg ttggtgcgtg cctataatcc cagctactcg ggaggctgag gcaggagaat 141600 cgcttgaact caggaggcgg agattgcagt gagctgagac tgcgccactg caccccagcc 141660 tggcgacaga gcaagactcc gtctcaaaaa taaaaaaaga aatcatgact gggtaaaaga 141720 tctgttcaga gtacaagatg gaccaatgga tttgatatat ttgaatataa cagagtatga 141780 aaaagtttat tgatatagtt tcagattaca cactgcaact aatctttaag aaactattac 141840 ttgtccactt tttggtaaaa tttcagagaa caatgtccac cattatctga acaggctatt 141900 aaaatactct tctcttttcc aactacgtgc ctgtgcaaag tcagattttt ttcatatact 141960 tcagccaaaa cagcatatca aaatggattg aatgcagaag tagatctgag aatacagcca 142020 cttttgttaa gccagacaat gagatttgca aaatgtaaac aatgctgctg ttctcagttt 142080 ttaaaaatat gttttttaaa agtatttatg ttaatgtgta cttggtttac tactgctatt 142140 tttaaataaa acaagaaaca tttttaaatg tctgttttaa tttctaaagt ggtagtgata 142200 gatataaccc atattaataa aagctctttg gggtcctcag tgattttttt ttaagagtat 142260 ggaagggttc tcagacctaa gagattgaga aatgctgatg taatgtttta ttataaaggt 142320 gtaccatgaa ttatgtacct tacttcatat tgttggacat taaagttgct ttcagttttt 142380 ttgttttaaa 142390 <210> 3 <211> 142390 <212> DNA <213> Homo sapiens <220> <221> gene <222> (1)..(142390) <223> c.3139-1G>C (Exon26 skipping mutation) <400> 3 gcaggaacgg gggcggggac ggcgctggag gggcgggtcg ggtaggtctc ccggagctga 60 tgtgtactgt gtgcgccggg gaggcgccgg cttgtactcg gcagcgcggg aataaagttt 120 gctgatttgg tgtctagcct ggatgcctgg gttgcaggcc ctgcttgtgg tggcgctcca 180 cagtcatccg gctgaagaag acctgttgga ctggatcttc tcggggtaaa gtgtcttcct 240 attcccgttt tcccagctcc gtgccccggg gtatctatag tgctaggctt ctgagacacg 300 tggaggcgct taggcccgcg gagcaggccc ctgggctgtg tttgggagat tctggaaaaa 360 cagactttct cccttttcct ttcccctctg gagcagctgg gaaaggcgtc tctcggagct 420 tccgccattc agaaagtgtt tccccgcccc tgacggcccc agcttgatgt ttaccttgcg 480 cgcttagtta ggattgctct ttctagtacg gcctttatta tggcagaaat tgagccacta 540 caggtctgca cagcaaagtc gagggaaata acctgctgtc tatgatttag caagtgatga 600 tggatatttt tgagttcaaa tcactcagtc tttaatggat tttcttttct ttttttccta 660 gttgaatctc agttgttctc aggctaggtt tgatatgaaa aatactactc cctattgaag 720 agggtaatat aattcttagg atgctaatac aggagtctgt aagtcggagt acttcaggct 780 ttttatggtt cggtacattt ctttttaggg gtgggatatt gggataagta ggacagttca 840 gatcttgatg tcattgaata gtggtgtcta cctaaaagga agaggctggg gcacaaaatt 900 ataatttaaa gtgtttactt cagccaaaat gaggacagct gcccaggact catttcccag 960 ttgccttggg gagtgctcct tcagccttgg ttacaagcag gtttttaaag gcgaagggga 1020 agagtgggct gagacaaagt tggtcaggaa ttgttattgg tttacagaga taccattgct 1080 tagtgattgg ctgtacactg taactcatag ggtatgagtt atcgtgtcca gcatatggca 1140 ttttatggct tcttggttcc agtctagagc ccatatagca ggtgggcttt aagagataat 1200 tatccagctc agaccgggag tgagacggga ctgttttttc attctaatgc ctctctgggc 1260 ctgataattt aaaggggctt gcattcttca gctaaaattt tattttcttt tatttttttt 1320 cccccacagt ggtctccctt tattaatcca acaaatgttt attaaggact gctctaggca 1380 ctagagatac caacaatgaa caaaacagac aaacatctct ctccttttgg agcttacatt 1440 ttagtggaaa gagacaggca aaaagtaaaa ttataggatg acagaaggtg aaaatagaga 1500 ttaaaaagga aagggggatg aagagtgtgt gtgtgtgttg tgggtggggg gctgtaggga 1560 gctgcagttt tacaataagt ggtcagggac gtcctcgctg agaagggaat ttttgagtcc 1620 agagctcaag gaagtgagag aacttacctt gacgttctct ggaggagaag aaagtacaaa 1680 ggccctgggg gaacctgcct ctttatgttc agagagcaac ttaagaggcc tagtgagctg 1740 gagcagagcg gagaggaggt cagaggtcag gccagaaagg gaaaggggcc agaatgtgta 1800 ggactttatg ggctatattg aaaattgggg ctttcattct gagggagatg ggaagctgtt 1860 ggagagttgt tagggaaacg tgatctgaat tatgtttcta aaaaattgga gtaagatatc 1920 ataaaatttg ccatcttagt cttttttgta tctggccaat tccactcaga attctttttt 1980 aaacagcttt attgagatat aattaatata tcatatgatt cactcattta aagtgtgcaa 2040 tacaatggtt tttagtttgt cttcagagtt gtacaacctt tatcacaatt acctttagga 2100 ctttttcatt acccaaaaga gaatctccat aaccattagt actcaatccc acccgctttc 2160 ctagcaatca cttacctatt tttttgtctc tatatagctc tcaaacccta tgatattcct 2220 tctatctaac tgtatttttg tactcattaa cagcctctct tcattcccac cacccatcca 2280 tcccagcctc tggtaatcac cattctactt actacctcaa tgacatcaaa ttttttagct 2340 cccacatata agtgagaaca tgcgatattt gtctttccct gcctggttta tttcacttaa 2400 cagaatgtct tccagttcca ttcatgttgc tgcaaatgac aggatttcat tctttattat 2460 ggcttaatac tattccattg tatatgtata tcacattttc tttatccact catctgttga 2520 tggacagtta gcttgattcc atattctggc tattgttgaa tagtgctgca ggaaacatgg 2580 aagtgcagat agctctttga catactgatt tcatttccct tgaatatata ccctgtagtg 2640 gatttgctgg acccgcttgt agttctacat ttaatatttt gagttatttc cataatgtta 2700 gtaataattt acattcccac caacagcgag gaaggagttc ccttttctcc acatcctcgc 2760 caacacttat cttttgtctt tttggtaata gccattctaa caggtgtgag gtgatatctc 2820 attgtgattt tgatttacat ttccctgatg gttattgatg agcaatgttt catatacttg 2880 ttggttattt gtatatctcc ttttgagaaa tgtctattca ggtcttttgc tcatttttta 2940 aatatggttt tttaattttt ttattttttt gctattgagt tgtttgacat ccttaaacat 3000 tttggaaatt aacctcttat tagatgtata gtttgcaaat attttatccg attctgtaga 3060 ttctgtcttc agtctgttga atttgctgtg cagagaagca ttttattttg atgtaatccc 3120 tttgtctatt tttgcttttg ttacctttgc ttttgaagtc atatccaaaa aatcattgcc 3180 cagatcagca gtccccaacc tttttggtac caaggactgg tttcatcgaa gacaattttt 3240 ccatccacag gagggagggg atggtttcag gatatttcaa gcgcattaca tttattgtgc 3300 actttgtttc tattattatt acattgtaat atatagtgaa ataattatac aattcaccat 3360 aatgtagaat cactgggagc cctgagcttg ttttcctgaa acttgagggt cctatctggg 3420 agtgatggga gacagtgaca gttcataagg cattaggttc ttctaaggag catacaacct 3480 agatcccttg catgcgcaat tcacagtagg ttttgcgctg ctatgagaat ctaatgccac 3540 cgttgatgtg tcaggaggtg gagctcaggt ggtaacgtga ggaatgggga gcagctgtaa 3600 agaaaaatga agcttcgctt gcttgcctgc tgctcaccta ctgctttgtg gcctggttcc 3660 taacaggcca tggactggta ctaatctgtg gccctggggt tgggaacctc tagccctgac 3720 caatgttagg gagctttttt cctgtgtttt cttcaagtgg tttcatggtt tggggtctta 3780 catttaagtc tttagtccat tttgagttga tgctgtatgt ggtgagagat aattgactac 3840 tttcattctt ttgcatatgg ttatcagttt tcccaacacc gtttattgaa gagcctgacc 3900 tttccccatt gtgggttctt ggctcttttg tcaaaaatca gttggctata aatatgtggt 3960 tttatttctt gggtctctgt tctgttctat tatctgtgtg tctctttatg ccagtaccgt 4020 gctgttttaa ttactagagt ttagtatatt ttgaagtcag gtagtgtgat gcccctagct 4080 ttgttctttt agctcaacat tgctttggct attcagagtc ttttgtgagg ataatgtttt 4140 caaggttcac ccatgttgtg gcatgtatca gaactcgatt tctttttatg gctgaataat 4200 attccatttg tttatattat atatatgcca tatttattta ttcatatgtt gatggacact 4260 taggttgttt ccaccttttg gctattgtga ataatgctgt tattaacatt ggtgtacaag 4320 aatctgtttg agttcctatt ttcaattctt ttgggaatat acctacgtgt ggacttacta 4380 gatcacatgg taagctttta gtttagcttt ttaaggaact gctaaaactg tttttccatg 4440 ggagcagtgt acaagtgttc cagttctcca tatgctcacc aaaacttaat ttcctttttt 4500 aaaaattata gctatcctag taggtggtgg gaagtggtat cttactgtgg ttttattttg 4560 tatttcttta atgactaatg atgttgagca tcttttaatg tgcttattgg ccattatatg 4620 tcttctttgg gaactgtcta ttaagtcctt tgcccatttt ttaattgagt ttttttttct 4680 gttgaattgt gggagatctt tatatattct gaatattaaa cccttattgg gtgtatgatt 4740 tgcaaataat ttctcccatt ttgtgggttt tcttcacttt ttgatattgt tctttgattc 4800 acttttaaat ttttatagag tccagtttat ctgttttttc ttttattacc tatgcttttg 4860 gcatcatacc taattcccaa atccaatgcc atgaagattt tctgttatgt tttcttttaa 4920 tagttttata gttttacttt ttctattgga gttttaagta aattcttgta tattagtgtg 4980 atacatttta agttattttt gtatatggtg tgaggtaggg gtccaacttc actcttttcc 5040 atatggagat ccagttgtcc cagcaccaca tgtttaagag tctattcttt ccccactgaa 5100 tggacttggc acccttgtca aaaatcaatt ggtggtaaat gtatggattt actcctggaa 5160 tctcaattct attctattgt atttatattt ctgtccttat gcctgtacca cactgttttg 5220 attacagtag ctttgtagta agtttagaaa ttgggaaaca tgagtcctcc aactttgttc 5280 ttcttttcaa gattattttg gctatttggg gtcccttgca attctgatga gtttgaggat 5340 caccttttcc atttctgcag aaaagccttt tgatagggat tgcattgaat ctgtagataa 5400 ctttgggtag tattgacatc ttaacaatat taagtctttc tatgcataaa catgggatat 5460 ctttccattt atttgtgttt tctttaattt ctttcagcag cattctgtag ttttcagagt 5520 acacgttttt cacctccttg gttaaattta ttccttggta ttttattctt ttagctgcta 5580 ttgtaaatgc agttactttc ttagtttcct ttcagattgt tcatttctgg tgtataacaa 5640 cagctgatat ttcaacgttg atgttgtact ctgaaacttt gttgaattta cttattagat 5700 ctagtagctt tctttgagat ttttatatgg gattatgtca tctgtatata gagatagttt 5760 tacttcttcc tttccattat ggatgccttt tatttctttt ccatgtctaa tttctctggc 5820 tagaactttc aatatgatgt tgaaaagcag tggtgaaagt gggtatcttt gtcttgcttc 5880 ctatcttagg tggaaagctt tcagtctttc accattaagt atggtgttag ctgtgggttt 5940 tcataaatgc cctttatcat gttgaggaaa taccctttta ttcctagttt tctgagtttt 6000 tatcatgaaa gggtgttgga ttttgtcaaa tgccttttct gtgtcaattg aaatgatcat 6060 gtatttttcc tcccttatct taatgtaatg tgttatattg attaattttc ttatgttgaa 6120 ccacccttgc ctttctgggg taaatttcag tcacttatgt tatatagtcc tttaaattgt 6180 gttatcttat aacagaatca ctctgctact gttttgagca taggccatag ggaaaagcag 6240 gtaaaaggta atatggcttg aaccaacatt gtagcagcgg aagtggtgag aggaggtcga 6300 attttggctt tgttttgaag atagaaccaa cagtatttgc tgacagatta gatgcagaat 6360 gtgaaaggag gagatgagtc aggatgaatc caaggctttt ggcatgagca accagaaaga 6420 tgaaggtgac ttactaagat gggaaatata caaaaggagc agtttgggga aactttatat 6480 ctattgagtg gaatatgcca attagagatt caaatatcca gtaaataatt ggctatcaaa 6540 gtttgaagtt aagaggaatg gtctaggctg tttatataac tttggaagtc attagtgtat 6600 aacagctaat ttaaaagcca gcagactcta agggagtgag tgtagaggga gaagagtaga 6660 ggtctgtgac ttgaatcctg gaatgctgtg atgtttagag attggggagg taagaaggag 6720 cagcagagta tactgaaaag ggattgttat actgaaaagg gattgatata gatggagact 6780 caagaattat cacagaaacc tgataaaatg tttcaagaag atgggtgtga ttaattgtgt 6840 cacttactgc cggtacattg actcagatga gcgttgagaa ttggctatag gatttgacaa 6900 cataaaagtc attggaaacc ttgacatgag cccttttcgt ggagtggagt ggttacagtg 6960 ggtttaagag aggattaaag gagtggaaac agagatgcta ttatagatga ctcgtttgag 7020 tagttttcct acaaagggga gaataataat ggagcagtta gccaaaagtt gagttttttt 7080 ttcttcttct tttttttagt tggaaaaaat tgcgtatatg ttgatgggtc ttttctggca 7140 gaccagtaga gaggaaaaag ttgatgatgt aggagatggg aaaatgtctt tgagtagatg 7200 tcttcgagaa aatgtctttg agtagatgag aggtttgcac acatggagag gttggatgta 7260 ggagtactga tagttcatcc atagttacat aagaaaaggt agatgtatta gagttctcct 7320 gagaaacaga accaatggga gatctttata tctctgtgtc catctctatc tgtatttctg 7380 tctctgtatc tatgaagaga ttataaaagt tttaagatct gccaggagac atacccacgg 7440 gagctaatgg tatagttcca ggccagttgt gaaggcctga gaaccaggag agcctatggt 7500 gtaagttcca gtctgagtcc aagtctgaag gcaggagaag accaatgtcc cagctcaaag 7560 acaggcagag ggagcagatc ttcccttact tagccttttt atttattcag gccttcaaca 7620 aattgaaggc ccacccacat tagggagggc aatctgcttt actcagtcta ctgaatcaaa 7680 tgttagtctc acccagaaac atcctcacag acacacccag aataatggtt agccaaatat 7740 ctgggcaccc catggcccac tcaaattgac acataaaatt aaccaccaca gtagagtata 7800 tgggtacaaa tataattatg tgatatagat ttcagggtaa gagcctgtgg aaattcattt 7860 ttgattgctt ctagtgaaat cggaagcaag atcatcagct aagagtgacg atcggtggag 7920 gagatatgaa gtttaagtgg agaggagaag gtataaaata gtcttaggag gggaggatag 7980 taaatagatt agggaaaagt tgtaggattg ccaggaagta gtaagggccc acttgaggct 8040 ggtggtcaca aatttaaggt gagaccagtc aaaatggttg tgcttttcac ctgctgcatt 8100 cattcagctg cataggtaca ggcacagagt aggtcaagag ttctttttta ttcggggtta 8160 gagttttgcc aggagatagt aataaagcca gaagggcaat gaatttgagg gagtatgcaa 8220 ggaagtggct gttaacttgg agtttaaact agtcaagaag agaattaagg actgcccaag 8280 gggtgaggac aatgatatgg tagcagggcc cttaaaagcc ccagttagat gaaaagattg 8340 ttggaattga gtttctagag ggaatgaact tgaaaaacag gaggtgttgg ttggagagtg 8400 ggatatatgg aattgagatt atggaaggat tcagtcgttg gtaataacat agtatctttg 8460 taggaataaa taggtggagc aggatgcaga caagatcact ggaggagggc tggtcagaag 8520 actgggaggc actatctccc ttggatatta tacatcaaag cttgtgatct actagacaag 8580 tagtggggaa agggtaggat atagatatta atggctatag ttttgatggt gatggtcatg 8640 gtgatgatga tggtccatta acactcaact caaataccat caatttgatt tatatctaac 8700 accacaaagt taggtgttga gttacatgtg gttatattgt aactaatagt cagcccttca 8760 tggacttcta ttctttgatg agactcttct tgtaggagta gtaggtgcct taaagcacct 8820 tttcatagtt gtcagattga aatccttcac cagtgtttta ggttaaccct gttactgtgg 8880 aagtttctct tggctttctg tgtgggctgc ttctttgtct agttttacct tttggggtta 8940 gcatactatt gtgaataatt tattggtgag aaggtaagca gagaagtaga gtactctatg 9000 acctagtaat ttcatatcta ggaatctatc ctatagaaat gataggaatg ccttacaata 9060 cccacatatc cacaagggta ttcattgaac gttatttttg gtgaaattcg caagcaacct 9120 aattatcatc aatagggaat tgttaaatta tgatagataa aatggaattc tattcagtct 9180 tcaaaaagtc agatcaagaa gtggtcttac attttaatta tcccatcctg tcaacaagag 9240 tgtcttcagt tgcaagtaat ggaaaaacca ttcaaactga cttcagcaat aaaaggttat 9300 ttattggtct gtttcatgga gacatctgag gtagagtggc cttcaggcaa gttcactcag 9360 ggatccgact atttttctgg ccttattctt ggccctcttc tatgaaaaca ccttcagggt 9420 ggtttcttgt atgcttgtaa gatggctact tgcatcaacc atgaccacat ctagcaggag 9480 caaaagcatc ctttcccgta ccagaggaga gtcccgaaat ttgttgcaat tggactgcct 9540 tggaagcaat aattatggcc aggagatgga ggctagagaa ctgagacctg atcatagctc 9600 ctatccttga atcagttgta tagcaagggg aattggattt tccttaagac agttggattt 9660 cacctgtagt cttggtgatg aggtcagttc catccataaa actttgctgt tacacatttt 9720 gggatggggt gaggagggct gaatggagat taggatgcta ttgaaatttg ctgtacacaa 9780 tggatcatta tcgtcttctt tcttagtgtt aaggtaatca gcctcttttt cctcctccta 9840 tgcttgactt tactaaaacc atgagacatg tttaacctca ggactccaat ttgaaaaaat 9900 atagactgtt atttacttta ttacttacag aagcccttca tactactctc agcaagaaag 9960 aggtaggcag ggagtgaggg aggggggatc atgcttactg agaaacaaac tatcgagtat 10020 tgaaactccc ccttcatatg cctgacctca gtcccattca gttaccagta ggggccccta 10080 ttaattggta cctcaccagc ttttgctgtt cgttcataaa actgagtcat tgaagtacag 10140 tagaaaaata attggactac aagataactt atttccttcc ataattgcaa aatatctgat 10200 ttttcttctt gtttgtatta tgtaaactta ccctgtctga gggtcctcct ggattgttct 10260 ttgcatttat atatacatag aatttcattt tcttttttct tgtttttttt ttagacggag 10320 tctcactctg tcgcccaggc tggagtgcag tggcacaatc tcggctcact gcaagctccg 10380 cctcccaggt tcacgccatt ctcctgcctc agcctcccca gcagctggga ctacaggtgc 10440 acgccgccac acccggctaa ttttttgtgt ttttagtaga gacggggttt caccatgata 10500 gccaggatgg tctcaatctc ctgaccttgt tatctgcccg ccttggcttc ccaaagtgct 10560 aggattacag gcgtgagccg cttgcccgac cttctttttt tttttttttt ttttttttga 10620 gacgttgaga tagagtctca ctctgttgcc caggctggag tgcaatggca cgttttcagc 10680 tcactgcaac ctccacctcc caggttcaag cgattctcct gcctcagcct cctgagtagc 10740 tgggattaca ggcgcccgcc accatgctct gctaattttt gtatttttat tagagatggg 10800 gttttaccat ggtggtcagg ctggtctcga actcttgact acgtgatccg cctgcctcgg 10860 cctcccaaag ttctgggatt ataggcgtga gccactgtgc ccggccaatt tcattttcta 10920 ttttgaaatt taaactacca ctgacacttc gttttccctc tgttttactt agcatttatc 10980 ttagagaata atcttaatat gtatagttct attttattct tttactggca gcttagtatg 11040 ccatattttg gatgtgtcat tgtttattta cctattaatt taccctataa ctgcttccca 11100 tatttttgct tttacaaagg gatgtaatga acatccttta catacgtctt tgtgcatatg 11160 tgcaaatatt tccataggat agatgtaatt actgacttga aggttatgca gatttaaaat 11220 tttgatgcct tctatgaaac atctttcaaa atggtgatgc cagtttcttc tctcgtaatt 11280 actgcatatg gtcaatcttt taaatttttg ctggtaatga tatttcaaaa ttataaccag 11340 ttttttggcc tcatttcttg aataacttgt tttttctcaa agataagaaa tgtctccttc 11400 atcgtatgtc aaatttccat atttacatgg atctatttct ggacatggca agttttattt 11460 atttattgta tgtatttacg gtgtacaaca tgatgttttg atacacatat acgtagtgaa 11520 atgattccta cagtcaaaca aattaacatg ttcaccacct tccatagtct ctgcagtctt 11580 caaggttttc tctatatggg attagacatg ctatgtctga tctgtttttg tatttttaca 11640 ccaattccac actaattttt tttttttttt tgactgggag tctcgttctt attgcccagg 11700 ctggagtgca atggcatgat ctctgctcac tgcaacctcc gcctcccagg ttcaagcaat 11760 tctcctgcct cagcctccct agtagatggg attacagcac tcgctgccac acctggctaa 11820 tttttgtatt tttagtagag atggggtttc accatgttgg ccaggctggt ctcgaactcc 11880 tgacctcagg tgatctgccc gcctcggcct ccgaaagtgc tgggattaca ggtgtgagcc 11940 acctcacctg gcacacacta ttttaattac tgtagtttta aaagtttcat atttagtagg 12000 gtgagttttt ccttgttggt cttgtttttc aaaaaaaatt tgctgctctt gagtattttc 12060 tcttcccagt gaactttaat gtaaactcac gtggttcaat gaaaaattct gatgactttt 12120 tttcttggta ttgcttcttg agtgtattga tttaattaat atatttacag ttttgggtct 12180 ggctgtgccg aaacgcagtg tgtcttatcc agtccttttt taactgtctt aataaaattt 12240 gctggttatc tttaaaatgg atcttgtata ttttatgtta ggtttattcc caggcaggtt 12300 gtcatttttg ctgttactga ttttggatat aaattttgga tataattgta taatttggac 12360 ttggatataa ttgtatttga ttctgtctta tatataaaaa tgagatagga taataattta 12420 tcctaggata aaaataattt gagtatcctt attttgcatc tggtacctta cttgctcctg 12480 ttaaacaaat agataaaatt acttgtcttc aaagagatcc tgtggaaaaa ttatttattt 12540 taggagactt tggagctttg ataaaaatta ggcttatctt ttgtaaaagc tggttagtga 12600 tagcaatcag actcttttaa aggtgatttt tttttctttc ctttgataaa atgcttaata 12660 tgagggagga ttaagaaaga ggatggcttt tgaacagttt cttcatgggg aaataagaaa 12720 ttagaataat ttcatgttct ccaaaaaaag gagaaaaatg accttccctc ctgagcctac 12780 ttcaagcctc tgtttctttc tgactctatt gttctcatct ctgcattttt ccaatctctt 12840 ctactgttag tgttttaggc tagctcctca gtggagggca gaaattcacc ttctctttag 12900 ctgtctttga aaccaagaag atagaggtat gagatcttcg tagtctgtag taagaataat 12960 agaagccatc agaaaaaaat atcaaagctt tgtagctgct cctggaagtt ttgatgtgaa 13020 gcaggagaca tcacctattg gtacctgact tgcttttgct gttcattcat aaaacagagt 13080 ctctgaaata cagtagaaaa ataattagac tggaggataa cttttttcct tccaggaatt 13140 acacaatcac aaaattgctg atttttcttc ttattcatgt tacataaact tatcctgtcc 13200 gaaaagactg tatttgaact tactatgtaa gatttgcttt aggtaaattt atggctgctt 13260 ccagaattgt gtattaattt tccagtttct tttttaccag tctccacttt tacctttccc 13320 tcttccccct atacttaaat tggtcttact gtaaaattta tgcgtttctc tttctacctg 13380 gcaatgctga tttttttttt tttttttttt ttgaggcaag gtctcactct ttcacccagg 13440 ctatagtgca gtggcaagat cgtggctcac tgcaacctcg aatccctggg ctcaagcgat 13500 cctcccacct cagtctccca agtagctggg actacagatg tgtgccatcg cacctggctc 13560 atttttgtat tttttgtaga gatagtattc gccatgttgc ctaggctgga ctcaagccag 13620 cctcctgcct tagcctccca aagtgctggg attgctggca cgtaccacta catccagcca 13680 gggctgagtt tctgaatcat cattgcagca agagaaattg gattaccttt agaccactgg 13740 ctctactgtg ggctgggagt gggacacctt ccttaaagcg cattggacat tggctttgtg 13800 ggtaactgat ctttacctga atgaaattta tcagtactgt attaagggtc tagggtggaa 13860 cggatgctag caaggcaacc gttaacatcc acttactgat gaatcctata aaattttatt 13920 tcaggccata cgaagtaaca gtaataaata taaaaggaaa aatagacaac ctaagcaact 13980 ttttaaattg acttacttga aaactttccc tgcaatttcc cggtttataa tggttgattt 14040 cagctgactg gctatagcta cttagagaac agaggaaatt cattaaaaat aatgaattat 14100 tcagttgggt agtgaaatcc agttataaag cacttcgctg tgccatggat tcagttcagg 14160 tcaagtgatg ttcctggttt atgggcagtg tggcttctca ctatgacaca gcaaagaacg 14220 tagcttttat cctttaccct tgttactaac taaaattaat ggcattttat tgtgtttatt 14280 tgtttgattc catttacagt ttatttcact tggttttatt agtacaaaat tgtgctttat 14340 ataatatttg acagttagga aaaattgtta gatacctata aagaaacaag tctctcaaaa 14400 atcatcctac tacttttaaa aattacatcg tcttactaca gttaacctag atgtgaatgg 14460 gtagttttat ttagcttttc tggtttgttt gcttggtctg tttggaggga agttaagatt 14520 agcagaaatg tagtaataga ttcatgaaag tcttgaaagc ttctttaatt agagaattta 14580 atgagggctt tggcatgcat tctttggttt ttctctgttt tcctctaccc cttcttattc 14640 tttttggttc attgaaaagt agaaagaaat tctcaaaaac cgtacaggag aataccttat 14700 aaatgatatc ttctgcaata aactatagat tgtatatatg tatatgtatc tagatacaca 14760 atctgtgtgt gtgtatatat atgcttgtgt gtgtataaat gtataaatta gttactagta 14820 tatacgtaag tataaaacct caatgtgcaa ggttacattt tcagaaaata tgtaatataa 14880 taaaagaaat caagcccaga atttttaaaa agtttattgc gctttctgtt aaaaatgaaa 14940 ggctttttga ctggaagctg cttctcagta aaaataacat aattgtgttg gtgaagccca 15000 aagattctaa tgaaaattag ggtattgaca accaaacgga attgctggag tacttaagct 15060 gctttggttt tgtaatcttt ctgtgtcaga atatttgaaa aacacttatt aatccagtct 15120 tgtaacttat ccttgaaatc tcttttttaa tattcttttc cacacacatg aaaagttaga 15180 tgagtgtatg aatttctgtt gtcagactag ttgtaaacct cctaaatata gtttctgcag 15240 tatagttaaa gagaaagaac atcctggcta acacggtgaa accctgtctc tactaaaaaa 15300 aaaatacaga aaatgagccg ggcatggtgg tgggtgcctg tagtcccagc tactccggag 15360 gctgaggcag gagaatggcg tgaactcagg aggcagagct tgcagtgagc cgagatcacg 15420 ccattgcact ccagcctggg cgacagtgcg agactctgtc tcaaaaaaaa aaaaaaaaaa 15480 aaaaaaaaag aaagaaaata ggcccagcaa ggtagctcac gcctgtaatc tcagcacatt 15540 gggaggctga ggtagggagg attgcttgag gccaggagtt caagaccagc ctgggcaaca 15600 tggtgaaact ccatttctac aaaaaataca aaaattagct gggcatggtg gcatgtgcct 15660 gtagtcccag ctacttggga ggctgagtgg gaggattgct taagcctggg gaggttgagg 15720 ctgcagtgag ctgtgactga gcaacagagc tagactctgt ctcaaaaaaa aaaaaaaaag 15780 agatgggttt tgaaattcag tacttttttt gagtgaggtc caatgggtca gaaagaagca 15840 ttggataaat gaatccattt tctcttctct gtttgaattt gtaatttgaa agaatattct 15900 acctataaag tacttcagtg cttaattagc tgtcagtgaa tttatatatc ttatctaatt 15960 catatggatt tgctattttt atctgtacct acagattcct gacctctcta aggggatccc 16020 agtatactat agggaatgag gtataataga agtaaaagac ctatcactag tcctgtcatc 16080 attccaactc atgtgtaatt atagtttaaa agaagtgaca tcatgtgtat tgctgtttat 16140 ctttacatta atcttgtggt caagaaagca aatactataa tatataataa ttatataata 16200 tcataagaca agtaatataa taatgggaat ataatcccat tttacaaatg aggaaatgaa 16260 aatttagaga aataaagtga cttgtccagg gtcacatgga tactaagtga ccaagtgtca 16320 aagcagaatt ttccaaataa cttaaagata attcttgtac aaatatagaa cgaacacatg 16380 tcatatgtgt tgtgttaatg agggaaccag aaggatgaca acattggttc agagagatgc 16440 aaagataaat atagacattg gaggaaaaag ttggaaataa gattgttagg ttagatacaa 16500 agctgtgtta taggccaata aaaaccatag actttgaggt tatctttttt actggacagg 16560 attcagttac acctttatga gaccaaaatt tattatttaa catgtggata ttagagtctg 16620 agttttaaaa ttattagtaa atgaccgtca aataaagata tgtcccctaa tgaaatactg 16680 ataatcgctg ggtgagcttg tgctcctata tgacattgaa atgacatact gccctctctt 16740 tgtcttctaa gttttggata cttttttttt tttttttttg acacaaagct gcattagaac 16800 ctaggtttct tgattttcag tccagatttc tttccactct acttcctgct tcttcatagt 16860 ataattttca acactagagc agtctgcata acttttgcaa aatcagctag tctttcttat 16920 tagttttcct ttgtgcaaag tgatgtagat acagctttct tcttcagaga aacattgtga 16980 aattcaatga atatttgtaa aatttgcata cgtgcccaat gtgagaaatt gaaattatta 17040 cttaagtatt gcaactgttc ttttaggata ttttgtttgc aaatttcaga gtaattataa 17100 atattcttgc atttttattg taatcagtat ttataaaaca gtgtatttca tcacattaac 17160 ctttacatat tttgaataaa atagtattga accattttaa atagtaagtg gaaatttttc 17220 cacattaaac agtataacgg gctaacagag ttaagcattg cattatttaa ctaataattt 17280 tttcctgaac ttcagattat tatctgtatg tgtcatataa cttgacaatt tttttttttt 17340 agtgcttttt aaaaagagtg ggatacttta ttcagtttag ccctcaagca attaggcaag 17400 tcagttacca tggtaacagt aggtattaat ttccttacct agttagaggt tttatgaaca 17460 aagaaatctc tgagttcatc caccaaaacc caactttctc ttgagactgg cctcttgaga 17520 ctggtgttaa atttgtctat tttctagaag atgacactat tctaagtgga aaatacggtt 17580 ctcttgaggt gaatttctac tctatcaaga gtgaagtaga gtatggctta aaagttaagt 17640 gattaaaaag ctaccctttc ttagctaatt tggaatgtaa ttggtcttaa tttttctaaa 17700 ttcgttctaa ccaaaatctt attggcgtga tttctattga catgaactag aagtgacttc 17760 agcagacaac ttgtcccaat atctaaatgc tgtcaaatag aatcacttaa gatgaatttc 17820 ttccaaaaca gagttcacaa ttttgacaga taatctctta gcatttaatt gactagtatt 17880 accaacctta tggaataggt ccactcgttt agctatcatg aggaccattt tgcaactaac 17940 ttatcaaaaa gccttcacca agaagttgca tatcttattg atattttaga atgcgattat 18000 ggagattaaa aatcaccaca atgggttgtt aataacgcca gccttgaact ttcagtttta 18060 gagcatttta tctgtgttct gtagtcaaag ttggtaaggt gtccagtggg tcatgtttga 18120 cttgctgctt gtttttgtac tgtgtgctaa atggtttcta catttttcag tggttgaaaa 18180 gtcaaaagaa gaataatatt ttatgaaatt taaataaatc caggtttcag tgtctatagg 18240 taaaatttca ttgtaacgtt gttatgctta agtattgttt atgacttctt tgctatagtg 18300 acaaacttga gtagttttga caaagatcat ctggcctgta aggcctagaa tagttactgt 18360 ctaacccttt agagaaaaaa attgctggcc cttgttctat agtatgaaaa aatatagcct 18420 tgattattca ttaaaaaatt attttcccat tttattgaca tacttttgtc ccctgattgt 18480 taaaaggaat gcatgttctt atagaaaagt tggaatatat agaaaagtat aaagaacaat 18540 atgaaaaacc atttgcaatt gtgagataac cactaatgtt ttggtataca ttgctccaga 18600 cttacacaca aacacacacg cgtatttatt ttatacaatt agagtctaat tttttttttg 18660 agacagtctt gctctgttgc ccagggtgga gtgcagtggc aagatttcag ctcactgcaa 18720 cctctgcctc ctgggctcaa gtgattcttg tgcctcagcc tcttgagtaa ctgggattac 18780 aggcgtgcac caccatgtcc agctaatttt tgtattttta gtagagacgg ggtttcgcca 18840 tatgcccagg ctggtctcga acccctggcc tcaaatcatc ggcctgcctt ggcctcccaa 18900 agtactggga ttacacacgt gagccactgc gccttaattt tttaatttgc ttttttcact 18960 tgaataatta taagaacatt atttttaatg actgtgtagt gttctgtttt atggatgtac 19020 catacttaat tatttagtca taatttatta ttatgaggtt gataaacatg ataatcagat 19080 tgagctcaag aagctagtta tagggttgca caattaatga atcccaggta cctcgctggg 19140 ttgctgaggc tgctattttt ttcctgcctg tttggaacac tgtgtttggg accaatgagg 19200 caaaagaaat tgaagagctg ccattttcaa ttattctatt agaagataca ttgaagattt 19260 gtcaaatgac atagacacaa cactaatcca gaagattatt taatcaaaaa ggcattcatt 19320 tcagatatga attcataaac atttgtaacg atcctcagtt tgaagaccat atagaatccc 19380 tgaagaactg gaagacacta tttgcttggc aaagagaagt ccccagacca actggggatg 19440 aaatattcaa agagataaat gaatactttg aaacatacaa ggtactatgg aaaaagagtg 19500 gaagtttggg acaggtaatg acaggaagat ataaaagctt tacattaagt tcaatctaaa 19560 actttattcc aagtaacagg ttgtcttatt catggagaag cagttgtaaa ttaaaacttg 19620 cctgtggttt ggaatttcac attaaatgat tacattaaaa attcaaatgg tgaacctaac 19680 taaatccaag ctcctacagt accttctttt cacctttagg tgaagaaatg cggtgagcta 19740 ttttattact gattatgtgg acagtccaaa ggaaggttca taagcgaaaa ggaaaaattt 19800 aaattattcc atgtgagcga ttcttacttt gcagatttgt tgaagtgtag ttactggctt 19860 caaaaagtgg tatccttaac tgacattttg aacacttgaa ttcactcaat aaaaaaatgc 19920 agtgatcatg tggaaaatac attaaggtat atgacagagt ttatggattc agagcaaaaa 19980 ttcagctttg gaaaagtgaa gttaaaatgg ttttttaagt gatgtttaat tggtgttatt 20040 tgaatcctaa agaagaatta atagtactag tagaggaaag tcagtgtgtc tgtgacaaag 20100 ctttagtatt attttgaaat acttgatata aaaaagttca cgtttactca aagcttactt 20160 aaatcatcag aataaattaa catgtttctt aattaaagaa aaggagaagc tattagactt 20220 aaaaaatttt tgcacccttg aaatacatac aatttgaaga gattaagttg ttggaatact 20280 ggttaatggt gaaaaaggag ttttcagtct atgaaagcaa agccttctcc tttgccattt 20340 gcttttttgt agtggttgct atgtagaatt cgaagaaaat attgttaaaa agtcttggtc 20400 aggagtagag tgtagcatga acccaatgca ttttaacgtt aataatgagg aaaaagggaa 20460 tgcatgataa tttcatcaag tcagaaaaaa atggaaaaag aaaaagagga aactgaagaa 20520 agtaactgat gaaagtaagg tgaaagggaa aacaactttt tataccacct gtgaatgaga 20580 ttaattttcg tttccatact gaaagacaaa tatattccaa ttaagccatt caaaataaaa 20640 aacaattttt ttttggtaag agatgggatc tcactatgtt gaccaagtta gtcttgaact 20700 cctgccctca atcagtcctc ctgcttcagc ctcccaaagt gctaggattt caggcatgag 20760 ccactgtgcc tggccaaaac caaaattaag caacaaaaca acaacaacaa aaattccaga 20820 cagcctttaa aataatgata aaggttgaaa aattgtagat agtggtaggt agataagatt 20880 tcaggaaaag tccaaagcaa atcataatac gttattttaa aggggggttt aaaatccttt 20940 aaaggtacaa tgtgaagcat tatgaaatga taaaatacat gttttttaaa aacattaatt 21000 ttattttaag ttccaggata catgtgcagg acgtgcaggt ttgctacata ggtaaatgtg 21060 tgccatggtg gtttgctgca cctatcaatc tgtcacctac atattaagcc ccgcatacat 21120 tagctgtttt tcctgatgct gtccctcctc caggacccag tgtgtgttgt tccccatgta 21180 ttctcatcgt tcggctccca cttataagtg agaacatgtg gtatttggtt ttctgttcct 21240 ttgttagttt gctgaggata atggattcca gttccatcca tgtccctgca aagtacatga 21300 tcgtgttcct ttttatggct gcatagtatt ccattttata tgtaccacat tttctttatc 21360 tagtctatca ttgatgggca tttggttttt ttccatgtct ttgctattgt gaatagtgct 21420 gcagtgaaca tgaacatgtg tgtgcttgta tctttataat aaaatgattt atattccttt 21480 gggtatatac ccagtaatat aattgtataa cccagtaata ggattgcagt gtcaaatggt 21540 atttctggtt ctaggtcttt gaggaatcgc cacactgtct tccacaatgg ttgaactagt 21600 ttacattccc accaacagtg taaaagcatt cctatttctc catagccttg ccagcacctg 21660 ttgtttcttg attttttaat aaacgccatt ctgactggca tgagagggta tatcattgtg 21720 gttttgattt gtatacaaaa aagatttgta tttctctact gatcagtgat gttgagcttt 21780 ttttcatgtt tgatggttgc ataaatgtct ttttttgaga agtgtctgtt catgtcctct 21840 gcctactttt taatgggatt gtttgttttt tttttcttgt aaatttgttt gagttccttg 21900 tagattctgg atatagacct ttgtcagctg gatagattgc aaaaattttc tcccattctg 21960 taggttgtct gttcactctg atttgctgtg cagaagctaa aagacatgat tttagaaaaa 22020 gacatgtcaa agtcatacat gctcaacgac atagcgagta catatgtaaa taaaaaatta 22080 ttttatgctg tgaatttgac cgaaaataac ctttacctcg tcaggaatta caatcctcac 22140 gtatggtaaa ggatttccct attgcaaatt attccacaac attaatgttc tgtgtgcttt 22200 ttatctatcc caagatacaa gtaaatttga caaagatatt aggtttgtaa acaaatttac 22260 gttcaaatct ttgcctggaa gtatctagat agaattttgc atgcaaaaga gtatttacat 22320 ctaaaaaatt acatatttca aattaaaatg attttagtgt tatagataga aggaaagagt 22380 tattgaagtt tatttctgtt ttggcagtgt aaatgaatta cttacaaaat tttagaagtc 22440 tacaggtgtt tttataaagt ttgtgttatt tgtggaaacc tcagttttct ggcattttgc 22500 caatgaggtc tactctaagt atagcagaaa tttgttttcc agctttataa atatatattt 22560 taagattaag aactgatttt acttatataa tctgggatca acttttggct tctcctgtca 22620 aggattttga atttgtgaca aaatatacac ttattgataa ccagtgacat atataaaatg 22680 ctttacaatt aataaagcat atgtatttta catatttttt cactacatat gacgcatgtg 22740 gcaaccccaa gagttgagtt gtacccatcg gcaaactttg atcatgattc tgtgaatata 22800 ggcaagcacc aattgcaggt agaacattct ttttttgagt cccaaaccgt gagaaacaaa 22860 ttacagaaat gtacctttct tttgcattag gacacgttgt agttttgtat gaacactcta 22920 gttttaagca gtatgtgcaa aaacattgca caaaggattt gtgtgttgat tttgggactc 22980 ctgtattatt aattatgtgg tttatttgac taccccacat tttcaagcat aaattaataa 23040 atccataatt ccaggcttat taacaataaa caatctagat agttgaactc tttcttgcta 23100 acattttcta gatatggact gtttggtatt tttctactaa taaagaccct tagtaagctg 23160 ccttctggtt tgatgtcatt gggatgttta ctgggaactt tggtggagat cttgcagtct 23220 ctctccccca gtggtgaaag aatgagttac aaaccagctt tccttcccag tgtacaatag 23280 cgatggagtt tgttctatat ggaaaatttg tttgataaaa gtattcttta aaattttttg 23340 ttccataaat tatcagtatt ttcagtttct gattcatgct tgggatagtt gctgcatatt 23400 gtttaatttt gtcagaattt atattgttaa atatcaaata cgacagacta ccctcaaatc 23460 ataagtagtt aatgtaatta acatcctgtt tcatcatgag actcttcagt gttacattaa 23520 aaactgctac ctcctgggcc gggcgtggtg gctcatgcct gtaatcccag cactttggga 23580 ggctgaggtg ggcgatcgga tcacgaggtc aggagattga gaccatcctg gctaacatgg 23640 tgaaaccccg tcgctactaa aacatgcaaa aaattagccg ggcttggtgg cgggcgcctg 23700 tagtcccagc tactcaggag gctgaggcag gagaatggca tgaacccagg aggcagatct 23760 tgcagagagc tgagatcgtg ccactgcact ccagcctggg cgacacagca agactccgtc 23820 tcaaaacaaa aaacaaaaaa caaaaaaact gctacctcct tattacaaat aggaactaaa 23880 gttgaagttt gaggaatttg ctaagaacta agccttgaac taaggctatt ttatttgagt 23940 atgagtcata tcagggtacg gatccatttt actattaaca aaacaaatat gttctgtttt 24000 ttttttttaa atgcacacac cacgtttgag agattcttat tcactgtatt ttctttaatt 24060 atacttgaat tttggtttac attgaggagt gccctcaaag atattaacag atttttaaaa 24120 aatcctctaa aaaactcatt cttagggaaa tttgttcact tactaggtga ggagcaaaat 24180 aaaaatcctt aatatagaag agctattatc tgtcttcaaa attaagtctt tgagtagatt 24240 tgtgaataaa tctaatagtt ttgctgaatt tacttagatc ttaagacaga ataatcatgt 24300 agaaaattta aaatgtcagg aattcataat gattcatata cccaaggatt ttcattgata 24360 gtgaggtaag gttattcttg agaaagactc aaagtcataa aataatagaa tttcgaaact 24420 accagaatta tacaagtcaa ttaaaatgac tgatttgttt taagaggaag aaatactaaa 24480 tgtataatta ttagatgcag catattgtat ctgttttgtt ttgtgattct agctcttata 24540 acctatgctt ggacctaggt gtcataactt actttaaata tgtatgtttg gttttcattc 24600 atattgacag tactacctct cagttttctt tcagatattg ttttgtattt acccatgaag 24660 acattgtttt ttggactctg caaataggac atttcaaaga tgagtgaaaa aaaattggaa 24720 acaactgcac agcagcggaa atgtcctgaa tggatgaatg tgcagaataa aagatgtgct 24780 gtagaagaaa gaaaggtatg ttgttcattg actattcttt tgggtgagaa atttaattta 24840 tatttgactg tgcaaagagt cagttgttac ttgtaaactt caagtcattg tttaggtcag 24900 agttgctgtt gtctaaatgc accaggacct agttgttgaa agggtaaact ggaataaact 24960 ttaattgggt ttacaaaatg agaattctta ctgtatattt tctctttttc gggttgactt 25020 taccagtttg ttctagttca gataatttag acaacattaa ctttgttgaa ttttttgttt 25080 gccagccggt cttcagcatt ttaaggcaac attattatta cagttgtaat acgaatataa 25140 ttaccagaga aaaaactcag gaaaataaat gcttttatga aaatgggatt agaggtttga 25200 aaataaactt gttaggagaa ataatttcac aatgggatgg ttttttcttt gttaagtttt 25260 ctttatgact tcattagttt ataaaacatt aattgataaa acttagaact ataaattgaa 25320 tgcttcagtg aactttatta tttcagtgaa catttgttat ttgatgtgaa ctttgtgcct 25380 gttttgaaat ttactaaact caaggcatgt gttcggaaga gtgtttttga agatgacctc 25440 cccttcttag aattcactgg atccattgtg tatagttacg atgctagtga ttgctctttc 25500 ctgtcagaag atattaggta agtgatttga atttcctgat tttatttgaa tttggaccct 25560 tagaaggtac tattatggta atgtttgtga atatactgag ttttacaggt gaggtgtgtt 25620 caatagataa ttatttctat gtatacacta tcaccaagtt ttacatttca aataaaagtc 25680 actgaattaa tttgtaatct gtcagtttgt tcattcataa gcttttctat tacttcagac 25740 agtttttttt taactttttt aatatatgtg ctgctgaagc gagcacgaca gttttttaac 25800 tttcagtact taagatgtta tatatagagc tactgaacat actgtgttta ttttaccaat 25860 ttagggaaaa agtgcaaaaa ttatttaacc tttaaatgca cctttatatt tcattaaaaa 25920 tatcaacata gtaatattga ataatggcta tgatcggctc tgttgtgtgt aattagtaac 25980 agttgtagca aatgatcctt aaaaaatgtt ctaactaaac attagaggcc aggcgcggtg 26040 gctcaggcct gtaatcccag cactttgtga ggccgaggca ggtggatcac aaggtcagga 26100 gattgagacc atcccggcta acatggtgaa acaccgtctc tactaaaaat acaaaaaatt 26160 agccaggtgt ggtggcgtgc gcctgtagtc tcagctactc aggaggctga agcaggagaa 26220 tcgcttgaac ctgggaggca gaggttgcgg tgagccaaga ttgcatcact gcactccagc 26280 ctgggcgaca gagtgaggct ccgtctcaaa aaaaaaaaat ccaaaaaaac aaccccacaa 26340 acaaacaaaa aacattagaa atgtctgtta gtacttttaa aggttgcctt gtaaaattag 26400 gactgcaata gtgcaatcta aggctctcaa agcataaaac aagtaataag gaattcattc 26460 agatattttc cgaggtggtt atacctgtct tttaaaaaaa aaattttgtt atatattggg 26520 ttaaaaaaag cagaggtgct gggcacagtg gctcatgcct ataaccccta cactttggga 26580 ggccaaggca ggaggattgc ttgagcccag gagtttgaga ccagccatag taagaccccc 26640 atctctacaa aaaaatttaa aaattagcca ggtgtctgtg gtcccagcta ctcaggaggc 26700 ctaggttttg ggcccgagag gttgaggctg cagtgagcct tgatcacacc attgcactcc 26760 agcctgggca acagggcaaa accctgtctc aaacagacaa acaaacaaac aaaaggcaga 26820 ggtaggttaa gctatttatt aatggtcttc tactggtata gatataagct agaaataaca 26880 ttcaagtgtt tttactttta ctacagttat ctggccactt tgggactcat tatactgaat 26940 tagtttcaca gaggaggtaa aatctgttgt ttatgattac atattaactc taccatttta 27000 ccttcagcat tgctgtagta tgtcatatct gaaggcaatt agcacaagtg acttgaagaa 27060 ttgtagtttt gatgacttat atgtatttta taaaaggcag gcagagtttt tgtgtttgct 27120 ttcccctcct ctggacactt taaatttttg ctaccacagg tttccaacaa tttgattatg 27180 atgtgccctt gtgtaatgtg gttggtgttt atttggcttg gagttcgttg aatttttttg 27240 atctgtgtgg gcttatacct ttaatcaaat ttgaaaaatg tcttcagatc ctttttcctc 27300 ccatcctgtt attcttttct ctttctggga ctcttagtac acacaagttt gattgcttga 27360 tactgtgtca caggccactg aggctctttc ctttcagtct tttcttcttt cttccttttt 27420 ttctttctgt gcttcatttt gaatagcttg aatagttttg tttcctgtct tcaagttcac 27480 ttatattttt ttcttctgta gtgtctggtc tgtttatacc atcctgtgaa tttctttttt 27540 agatactaca tattttgttt atctctagaa gtcccatttg gttcttaatt tttttttcca 27600 ttttggctct cattattcat gtttctttca aaattcttga acatatttag catattttta 27660 atagctgttt taatgtactt gtctgttaat tccattattc tagggttttt ttctttctat 27720 tggatgattt ttctcctgat tatgggttat attttcctgt ttattcctac agctgttaat 27780 tttttttttt ttaattaggc attgtgatct tactttgtgg aatgttagat tttattgttt 27840 tcctttaaag aaaggaactt tgtcagacat ctaagttacc tgaagatcaa ctttatgttt 27900 tgaagcttgt tttcaagctt gatcagggaa agtctacgtt tgcctttagt ctaaaggtaa 27960 tttagcccta taataagatg tgacccttct ggagtctttg tagactgcct ctggtgatca 28020 acgatctctt ctctgacttt tcagaacgtt aatgcctctt acctttgtgt aagtccgtcc 28080 taagaatcat tcagcttatg gttgtttgcc cagccccata gagttttagt ctatgcatgc 28140 ttgtcttcgt attctgcaaa gaccaaagga gtcccttagg gagatttctg gagctctttt 28200 cctgcctagc ttcctcctct ccagaactct gccccgtgag ttccaggtcc ttcagcttcc 28260 agggctctga actctgtctc cccaactcag tgctctcctt gggattcttc tccctgttct 28320 gttgtctgca atgggtccca ggaagaatgt ggggcaactg taaggttcac ccttcatttc 28380 ccttccctta gagatcatag tcctgtactg cctgttgtct agtatctgaa acagttgttt 28440 tatatgtttt gtccaagttt agatttgttt gtggtgggag ggtgagtctg gcctcccttg 28500 ttatatcatg ttggcctgaa gcagaagctg agtttctttt attttttaaa tatagtttca 28560 atttttaaca actattaaat aggcaagtat caacaacaat agataacaat ataatagata 28620 tgcatattcc tcccacttta tcaaatctta attttcttca attttttttt ttttttttaa 28680 tagggtctca ctctgttgct cgtgctggag tgacagtggt gtgatcttgg ttcgctgcaa 28740 cctccgcctc ttgggctcaa gtgatcctcc tgcctcagcc tcctgagtag ctgggactac 28800 aggcatgcac catcatgccc agataattta tatatatatt tttttataga gatggggttt 28860 ttgccatgtt gcccaggcgg tctcaaattc ctggactcaa gcaatctgcc tgccttggcc 28920 ccccaaagtg ctgggattac aggcgtgaac cactgcgcct ggcctgtttt cttcagttct 28980 ttattaagaa atgaaacagt aaaatacagc tgaagccccg tgtttgttct ttctgattct 29040 ccctctgtgc ccctctgaga taacttctat gagttttgtg catttttttt tctttttaat 29100 aaaaacaggg tcttgctctg ttatccaggc tggagtgcgg tggcgagatc atactcaatg 29160 cagcctcaac cttatgggct cgagtgatcc tttcgcctca gcctctcaag tagctacaac 29220 tactggtgtg tgctgccatg cctggctaat tttttattta tagtttttaa agacagggtc 29280 tcactatgtt gcccaggcta gttttgaact cctggcttct agtgatcctc ctgccttggt 29340 ctcttactta aagcactggg attacaggtg tgagccactg gctgctcaca tgttttttat 29400 aatagtactt aataatttta tgtctgaaaa tattatataa tgttattttg cccatttaaa 29460 aactttaaaa aatgctaaca aactgtgtac tctgtaactt gtctttttta ctcaacacta 29520 cgtttttgag aatttttctt gttgatctgt gtagttccat tttaactgtt atatcttact 29580 atgtttcatt atgcaacagt tggttcaatc cattctcttg ttaatggaaa tttagtttgt 29640 ttctaatttt tgccagtagg aacagtgttg caatgcatat tcttaaacat gtctgtacac 29700 atctgagggt ttcatttatt tgtgacaaaa cttgccaggt catagtgttt atgcaccttc 29760 aactagatat tgtcgttgtc aaagtttttt tccaaaagga ttttaccaat ttatacatga 29820 accaccgata gatatcctct taacacgtgg tattctgaaa cttaattttt accaatcaga 29880 tagatgtgaa atcacgtaga cttagtttgc atttctttga cttctagtga gaagtagtgt 29940 cttcacatat tttttggatt tttaaaattt attttttatt tttgtttttc ttagagacag 30000 ggtcttgaac ttttacccag gctgaagtgc agtgatgcga tcatagctca cgctaacctc 30060 gaactcctgg actcaagtga tcctcctgcc tcagcttcct gagtagctgg gactacaggt 30120 gtgtgccacc aagcccagct aatttttaat tttttttttt gtagagacat gctgtgttgc 30180 acaggttggt cttaaactcc tagtctcaag cagtcctcct gccttgactt tccaaagtgc 30240 tgggattaca ggggtaaacc accatacctg gccatatctt ttggatttat tggtcatttg 30300 gattttcttt tgggaattac ctgttcatat ttttctccat ttttctgctg aataatttgt 30360 cttttcttac ttatttttca agaaatttta catattttct ggctgttcat tgtcagttgt 30420 atgtgctcca gataacttga acagtctgtg gttgcctttt aatttttgaa ttatgtcttt 30480 agttatgcag aagtttaaaa ttttaacata aattaattta cactattttt ctcactttag 30540 catgagtcta tcagatgggg atgtggtggg atttgacatg gagtggccac cattatacaa 30600 tagagggaaa cttggcaaag ttgcactaat tcagttgtgt gtttctgaga gcaaatgtta 30660 cttgttccac gtttcttcca tgtcaggttg gtatctctac atttcatttt tatatggctg 30720 ataattgtaa tatgtcaact ttatccctat aaaattaagt tcttttatta gctggccgtt 30780 ctctcattat ctcaaattta tttaagtatt tatgttctac ctgattcact cacattcctt 30840 gttttattta attttcacaa catacctgtg aggcattgac attttttctg ttttagagaa 30900 gagaaaactg aaattttaag aggctaaatg accaggatat gtactgctat tgctagcagg 30960 agtggcattc aaactgatta ttttttcttg tcatttatca atcaggactg tttgctttag 31020 ttaagaaata ctcaaggtca atgtgtttct gaatttaaaa ttactgttaa atacaaattt 31080 acacataaac atggtatgta taagaagtag gacataaatc catcatactt gacagaactt 31140 atggaaataa caagaaaatg ttacagtttt tccccaggga ttaaaaatgt tgcttgaaaa 31200 taaagcagtt aaaaaggcag gtgtaggaat tgaaggagat cagtggaaac ttctacgtga 31260 ctttgatatc aaattgaaga attttgtgga gttgacagat gttgccaata aaaaggtaaa 31320 agcaatatat atataatttt catgatgaag attattttgt gttacacaga atgtactttc 31380 tatctgaatg ttagattttt ttttgaaaaa gcttgttata taatgttttt gtagcaataa 31440 aaaagttcca agtgaatgtt ctttaatgaa aacctttatt tatttattta tttttaactt 31500 ttgtttcaag atcggggtac atgtgcatgt ttgttacaca ggtaaacttg tgtcatgggg 31560 gtttatcata cagattattt tatcacccgg gtattaagcc tggtacccat tagttatttt 31620 tcctgatttt cttcctccct cctcccaccc tccacctccc acagtgtgtg ttgttcccct 31680 ctgtgtgtcc atgttttctt atcatttagc tcccacttat aagtgagaac atatggtatt 31740 tggttttctg ttcctgcgtt agtttgctaa ggataatggc ctccagtgcc atccatgtcc 31800 ctgcaaagga catgatctta tttatttttt ttatggctgc atagtattcc atggtgtata 31860 tgtaccacat tttttttaat gcagtctatc attgatgggc atttaggctg attccatgtc 31920 tttgctattg ttaaatagtg ctgcagtgaa catatgcgtg catgtgtctt tgtaacagaa 31980 tgatttatat tccttttggt atatacccag taatgggatt gctggggcaa atggtatttc 32040 tttctttagg tctttgagga attgctacac agttttccac aatggaaagc ctttagttct 32100 aatccatgtc ttggcataga gtttcttttc tttttttttt tttttttgag gtggagtttc 32160 gctcttgttg cccaggctgg agtggaatgg tgtgatctca gctcactgca acctccacct 32220 cctgggttta agtggttctc ctgcctcagg ctcctgagta gctggggtta caggcatgca 32280 ccaccatgcc tagctaattt tgtattttta gtagagacgg ggtttctcca tcttggtcag 32340 gctgatctcg aactcctgac ctcagataat ctgcctgcct cggcctccca aagtgctgag 32400 attgcaggcg tgagccaccg cacctggccg gcagacagtt tctttttttc tttttgagac 32460 agagtcttgc tctgtcgccc aggctggagt gcagtggtgc aatcttggct cactgaaacc 32520 tctgcctcct gggttcaagc gattctcctg cctcagcctc ccgagtagct ggcactacag 32580 gcgtgccacc acacccagct aattttttgt atttttttta gtagagacga ggtttcaccg 32640 tgttagccag gatggtcttg atctcctgac ctcatgatcc acctgcctcg gtctcccaaa 32700 gtgctgggat tacatacagt ttctttaagc aagccttctc ttttccttcc tcccagttct 32760 tggtactctt tcactttcat atatttgcaa atgtaaaatt gtgttttagg tgtatatttt 32820 taatccatgt ataccagtaa cttaaaaaaa aatttttttt tttttaaggg agagcataat 32880 ggagctcttg tgatacggtg ctcttagtgg aagtttggct atcaattcca tcacctgtat 32940 ttcacatatt ttattaatga agttcttaaa ttaaattctc atatttagcc aagtattcat 33000 ttggctggga ggtagaaagc ctactaacca actttttttc atgaacaata tttttaaagt 33060 ccaagatttt taatacctac attagggaaa ttctagaatt aaattcttac aatgtggact 33120 gcatatgagg cttttagtga cagggaattt gttgaaggct atctgtgggt tgtattttgg 33180 tataacattt cctaatttta tttgtggtat gttcatttga tatcatttgg taatacctga 33240 aaacaggaac tgattttact gtgttgcttt ttcatcattt ctagctgaaa tgcacagaga 33300 cctggagcct taacagtctg gttaaacacc tcttaggtaa acagctcctg aaagacaagt 33360 ctatccgctg tagcaattgg agtaaatttc ctctcactga ggaccagaaa ctgtatgcag 33420 ccactgatgc ttatgtacgt gcttaaagat ctttagaaat tgtgatgtgt tttaaaaaca 33480 ttattataaa tgactttaga aaaattttat tatagtagtg gcagaaactc taccaaaata 33540 ttttatatca atttggcatt gaaaaatgct taggaagaca tttagtgaaa ctattcattt 33600 tcgatattaa ttagcaagta ccaatcaaca gattgttcaa tgctagttta ttttcattgt 33660 catgaagcca aattaatgtc taatttgtat gttaaaaaat gtgaacttgc tgaaaacatg 33720 aaaggctaat aaatccaggc tgagcaagca taaatagtac tgatgatgga tttgatatat 33780 aaacaattca gaatgaaaat aattatagta cagtttctat tttaaaactg gccttatttc 33840 ttatatataa aatgtggtga aattttagaa aaattgcctc caaatttagc ttgttgctgc 33900 cattagatat atttttatat ttacatgttt gtatgtagtg aaatctgggc ttatctttat 33960 atatagcact attgtgtgtt ttttaagaaa tgtattttat tccacagtga atttgttttc 34020 tcctaactca tgctttcatt tgtagatgaa tattttattg tttctccttt gcatctatca 34080 aaggaatgga aactcctttg aattgtaacc agcaaacaat tcacttttgt tagggaaatt 34140 ggatgataat tttcctttaa aagataccgc caaacttgag actaacattc tcagctgatt 34200 taagtaggat ttctcttact agattgcatt ttgttagatt ccattttaag ttattttatt 34260 tggatattgt gtgtaatatt gagtgtgaaa aagtgaaaac aaacttttaa ggctcaggca 34320 cctttctcaa ttttcacaat tggtatgatt attaaatgag gacatattga tatttgtgtc 34380 acataatagg ttgaattcca tgtttgggtg ctttgtgaat cattctcttc gatttttctg 34440 aagatgggac ttactgtttt atttcggtga tctttagcat actttttaaa tttttctgtt 34500 tttttatagg ctggttttat tatttaccga aatttagaga ttttggatga tactgtgcaa 34560 aggtttgcta taaataaagg tatgttaaga tccataaata aaatgtgaat tcactctttt 34620 gtgaggttta tctccaaaaa aggcaatatt cacatatttg caaagcattt agtactataa 34680 cttcttgaat gtctgagcag tcctgacatt agggtgggat ccatcagggc ccaagatgag 34740 tgtttcatct ttgttacttg tggcaaagca gcccttactt cttttacttt gtagcattgc 34800 tatgtatttg gcttctagag ttggggcttt gtggctttct tattgcagtg acacaaccag 34860 ctttctccta gtctggagat tatacatcct tgctataagt atttaaaatg ctttctatat 34920 aatgctttaa aacatgtaag atggcttatc cccaagatgg tagctaataa acactaagtg 34980 ataaagtagg taaagatcta tttattcatt tattaaatat tgttggtcat tttacagtgc 35040 tttctaacat actgatttac atttctaatt ttcttctgtc atttttctcc aaaaataatg 35100 gtcatgtcat ccaacctcag tgctgttttt agaggtcttg ataagccagt gagagcagaa 35160 ggagccacgt agtagagtgg gtgagcccag gctttttgtt gcacagacca atgtgaatcc 35220 cagccatgtg acctgggatg tacctgtttc tccaaacatg gaatgtagat actagcataa 35280 tgtccgtttt accgttttat agaataattg tgaagactta aagggacaaa ctattcgaag 35340 catctgtatt gatataaagt tatcactatt ctcgtagctt ccttttggag attttaaatg 35400 attgtgtttg ttaagatgtt aattaaatta ggccattttg ctaaatgctc ttaaaaatat 35460 ggcatgactg cctcatataa aatgatatga tattctttat aattgtcgtt gagcctctgt 35520 gggtggcagg ccctccttta tatgttaagg tagaagagtc tttattctta cttctcctcc 35580 ctggagagcc acttcctatg aatgcctgct ggttctctgt agtcagaggt cttgtggctg 35640 taacttagag tcagtctcca tatccctggg ttctgcatct gtggattcaa ccaaccacag 35700 attgagaaca ttcaagccaa aaaaaaaaat tcacagtttt aaaaaaggaa aagttgaatt 35760 tcttgcatgg agtaccacat tgaatctata tgaatgaagt gatgcgtagg cattttataa 35820 ggtattataa gaaatccgga gatgatttaa agtatacagg acaatgtgta tagattatat 35880 gcaaatattg cagcatttta tataagagac ttgatcatct atggatttga tatcagtggg 35940 agggaggttc ctggaaccaa tccctcaagg atacagagga atgactgtat gttaattaac 36000 tgaggcaggt gatcggtttt ttaagctgat tagggaaaca gtatataaga acttacttaa 36060 ctcataataa aactaaaatt caacagggga gagttatgat tttttggctt tatggttgtg 36120 gaattgcatg taggttacat gtacaatttt gttacatgtg caattttgat gaaaatgctt 36180 ccaaggaatg tttatgatat ttttcactaa agtaacatat attaataaca cagtactgga 36240 agtcctggta tctgtgtact tgtcattgta atgctacatt atttgacctt cacttttttt 36300 cccctttatt acattatatg tgtgagtata ttgtgacatc ttgactcaga ttccagtgaa 36360 ttgtattagg ttggtgcaaa aataattgtg gttttggtaa tttttaatgg caaaaaccac 36420 aattactttt gcaccaacct aataactaag attaccatct ttttttcctt ccttcctccc 36480 ttccttcctt tctgttattc agccagaagt atcagcatca ctgttctctt attttcttca 36540 tgtacatatg gatgatattt tcgaatgacc acttttctct tttgcttttt attattagac 36600 tgtttttttc ttcttgttaa aggataaaaa gattagaaca taaaaggata tttacacatt 36660 gtttccccat tgacttattc ccaagatggt agctaaaaac accaaatgat atagtagtta 36720 aagatacatt gactcattta ttaaatattg ttgagcattt tacgatatgg gaataccgta 36780 gtgaacaagc caggcatact ctgtttcctg aggggcctac agttttattg gggatataga 36840 tgagtgaaga aagcaattgc agtgtaggga gatgagtctt atgtcatggg aaaacaaggt 36900 gctgtagttg acacaccgag aggcatctga cacattgggg gaaatattct agaatatttc 36960 ctggagaaag tgcaggtaaa agccagacct gaaacctgag caagagttag ctaaggccag 37020 gtgcagtggc tcacgcctgt aatcctagca ctttgggagg ccgaggtggg tggatcacct 37080 gaggtcagga gtttgagacc agcctggcca aaatggtgaa acaccatctc tactaaaaat 37140 acaaaaaatt agctgagtgt ggtgacgggc acctgtaatc ccagcttctt gggaggctga 37200 ggcaggagaa tcgctttaat ctgggaggtg gaggttgtag tgagctgaga ttgcaccatt 37260 gcactccagc ctgcacaaga gcgagactct gtctcagaaa aaaaaaaaaa aaaaagttag 37320 ctagctgaag agtataggaa agaatgggta caggaaatta caggtgccaa gttacagagg 37380 tgagagaaat tatggtatct ataggtaatt gaaagtaatt cagtatagtg aacattgaat 37440 agggctgggc ggatgaaggc aaagcagaaa aaggaaagca gatgggccat ggtaaggagt 37500 ttatatctcc tcccaagagc aatcgaagtg actgagagtt ttaaacacag cagtgaagtg 37560 aattacatta aaaaaataag aacttgggct ctagaataaa aaacggatat aggaggaagg 37620 caggagtcac agtaggaata tcttttggga ggctgtgaca ataatccaag tgagaagtaa 37680 tggcaacttg agtcggttaa ttgtgttgag aatggagaga agttgacagg ttcaaaattc 37740 atttttcttc tttttttgag tctcactctg tcacccaggc tggagtgcag tgatgcgatc 37800 ttggcttacc gcagcttcca cctcctgggt tcaagtgatt atcctgcctc agcctcctga 37860 gtaactggga ttacaggtgc ctgccaccac gcccagctaa tttttgtgtg tttagtggag 37920 atgtggtttc gccatgttgg ccaggctggt ctcgaactcc tggtctcaag tcttccgccc 37980 acctcagcct cccaaagtgc tagaattata ggcatgagct accacacctg acctcaaaat 38040 acatttaata gagcaagcat gagccactat gcccagcctc aaaatacatt taataaacca 38100 atggaatttg aggtaatgat gaaagacaca tgtcaaggat cattcctgtg ttgttggcat 38160 aagcaacagg gatgaaaagc attgaggaag agcaagattt tgggatgcgt tgtcacacag 38220 ttgattttag gtatgttaag ggagggagac ctgtaagaca gcaaagtgga ggtggtgcaa 38280 gaattagttg tgttggctgt agcacagagg acagtttgag ttaagagagt tgggactgag 38340 aatcccgagg aactcttagt gttgaacatt tgcgtggagg aggggacacc aaaggagttg 38400 ccatagacat cgaggaaatt aggaggtgtg gtgtgcagaa agccaagtga agaacatgtt 38460 ttaagtagga ggatgctatc aactgtttta aattctgctg agagtttgag aaactgagga 38520 cttagaattc atcattagat ttggcaatgc gccaatcatt tgtaatcttt taaacaatag 38580 ttttgctgta ctgggtagca aaagagtgat ttgaggagtg gtcatttgga gcatatgcta 38640 ttcaaacaga gaagagtcca cgggctttgg taacatgaag gtcctataac catagcaaga 38700 gaatgaggtg ggtggaagtc atattaacgt gaatagagga gtaggttaga tctgaggaat 38760 gtgggaacag agacagggtc tcattatgtt gcccagcctg gctcagactc gtggcctcaa 38820 gcgatcctcc tgcctcagcc tcctgaatac ctcgggtttc aggcctctgc atctggcttg 38880 aaaacaacat tttctcagaa gcttgtttta gttgttttag aaataacgaa ggcatgtgta 38940 aacaactgtt ctagaagctt agtttggaaa gggaacgttt attgatgcat ataacactta 39000 tatgttgggt gcttatgtgt caggcactgt tagagttgct cgggaaaatt tacaaaccaa 39060 gcaaaccatg ccccttcatt tcctttgggt gaagtgaggg agccatgtgg ttatctgaag 39120 gaagagctta gcaggattag agggaagaaa gtgcaaagcc tcctagggtg attggctggc 39180 tcttttggag gaacagtacc tataactgaa tgaaatgagt gagggtaaga gtggcaggaa 39240 atgaggctag aaaaggagct tgggccatat cacgtagggc ctcgtaggct gtgaatctga 39300 cttcatttct tattaatgaa aataaatacg atgatgggtg atgggaaacc catagaggat 39360 ttggagcaga agaatgatat aattaaaatt ttattttaga aatatttttc tggttgtcgt 39420 aagaggaaaa atatttagcc ccagggcatt ttggcagaga gttaggaggc tattgtaaca 39480 gcccaagcaa tagacaataa ttgtttggat taggcgggta gcaatagagg tgatgagaag 39540 tcgtagcttc tgtaggtatt tggaagatat atattgtgaa ggatttgctg atgaattccc 39600 tgtaaggggt gagatgtaaa gattcataga acattaagat attttggtca gatcatctga 39660 tcaatggaaa ggtcagttat agtggacaga ttatgagaag aacaggtttg ggtgagaaaa 39720 ctttagattt cagtgttgga tatcctaagt tttagatgat tattgatatc caagagatat 39780 caatatttgg gatcaatttg ggaaatatga tcccaaagtt caaggttgag gttggagatg 39840 taattcagat ccgatggtag ttaaagcagt gagactgaat gagataaaat agggagtgaa 39900 tgaaataaag agtaggtgtg atattgacct caagggcaca ccagcattta gaggttggga 39960 agatgaggag agagcagcaa agaggactgg gagggccact aatgaaggag ggaagtacag 40020 gaggtgttta gttctgaagc cacctgaaga aaatgtttgg aataggaaga agttgtcagt 40080 tgctttaaat cattcgggga ggttgagtga gatgagagtc tagaactaac agttaggttt 40140 gatggtgtgg aggccatcag taaccttttc tttctttttt ttttttgaga cagagtcttg 40200 ctcagtcacc caggctggag tgcagtggcg cgatctctgc tcactgcaag ctccgcctcc 40260 caggttcaca ctattctcct gcctcagcct ccggagtagc tgggactacg ggtgcccgcc 40320 accatgcccg gctaattttt tttttttttt gtatttttag tagagacggg gtttcaccat 40380 gttagccagg ttggtctcga tctcctgacc tcgtgatcca cccgcctcgg cctcccaaag 40440 tgctgggatt acaggtgtga gccaccgcgc ccggcccaag agtaaccttt tcaaaagcag 40500 ctttgctcta ctgatttggg taaaagctta gttgcagttg gtttgggagg aaatgggagc 40560 agaaaatttg agagagtgag tgtagacaac tctttcaagg aatttcgcta taaatgggag 40620 tagagatctg aagactgaat aattagcaaa ctgaaaagtg ggaagacgta attctcttat 40680 tatttcattt ttcttagtga aataagaggt gaagttctct gagtaatagg agggtcaaac 40740 aggtgttaga agttcacaaa gaaaggaaga ggtttgaaat agtcattttg agagtgggaa 40800 atgtagaaga attaacagtc attgctgagg gtgcgtttga aatctgtcat gagtttaaaa 40860 taacttgtgt catcatcgat gtgtttattt tcaactatat tcaactgctt gggtgtaggc 40920 atcaggtagg taaaaaaagt gggttttatt atgagtagag gttttgccac gtaattacca 40980 tggagggagg gaagagcaaa ggagttgaga gtatagatac aaaggaatga ttactgtaat 41040 gtgggtaaga gaggaatgga aggctcagtg ggcagtggga gtagggatgt tgataggtaa 41100 ggaaaaggtg ataggatcaa tgcatttggt tctgcaagtg tcaaagtatt gttggggaaa 41160 gcatgctgga aggaaagata gggatgctgg tgttctcagg gtggaaggct tacagttgta 41220 gtctggaagt ggtgatttta ttggcaatta taaggtcaac ggtatgacta tggaattgag 41280 tggctaaggt ctgttgaaga aaagattgtc ggaaatgcag gggtcaagga actggcctgt 41340 ggatgttgaa ctcactggca gtgatcaagg aatagtagtg gagtgaaagt agttaatgaa 41400 tcaggcacta agatctccaa gggatgaaag gatgcagttt ggagatgaca agataactgt 41460 agtaatcagg aatagcaggt tttgtagctc tgtctcatag gcctcagagg agatgggctt 41520 ttgaaggaca agagaaatga tgatgaataa attctaagca ggggaagtgt ttgggaaagc 41580 agggcaggct ttgtgctgtt gatggcaaat gatgtaccag acaggatgaa gttgagaatt 41640 tggaagttga tcactgatta gaaaggctta cattttattt tggccggggg tggcagctca 41700 tgcctgtaat cccagcactt tgggaggcca aggtgggcgg atcccttagg ccagaagttg 41760 gagaccagcc tggccaccat tgcgaaacac tgtctctact agaaatacaa aaaaaaaaaa 41820 aattagctgg tcgtggtggc acatgcctgt agtcccagct actccggggg ctagggaatg 41880 agaatagctt gaagccggga ggtggaggtt gcagtgagcc gagattgcgc cactgcattc 41940 cagcctgggt gacagagtga gactctgtct caaaaaaaaa aaaaaggaag ggcttacatt 42000 ttattttggt gctgactggg aatgaaggca atgagggatg actgttggag aaggctgtgc 42060 ttactaaaca gtattattaa gtagcagcat acatggtgtt atactgactt ctgattttgc 42120 aatagtacag acaggttcag attctcattt ccaccttctc cttctgccta ggtgaataac 42180 tgctgggtta tagtacagat gactgcagat catttggaat ttactttaaa tgtaaacagt 42240 aaaaatttga aagagaggga aagtgattga ggcaatttgg ggattgaata agaaggtctt 42300 tttgttggaa ttcatttaag gaaagaaaat gaaaatttga tccctaatat tatttaatga 42360 agtggctaaa tgaatatctc tgctttgtgg tttgaaaatt aatattgatt ttttttcccc 42420 ctagaggaag aaatcctact tagcgacatg aacaaacagt tgacttcaat ctctgaggaa 42480 gtgatggatc tggctaagca tcttcctcat gctttcagta aattggaaaa cccacggagg 42540 ttaaatatta cctttttttt ttttaactta aatcaattct gtttattttt ttatcacatt 42600 ttcctatatg tgaagaatac tattcattaa ggctgactca tagaaatttg cttgaataca 42660 cacacacaga ctgatgcata aatttgagaa atatctttcc agttgttgaa tagtgaatcc 42720 aaaggtttaa gccttttctg tctgctttgt aggatgtttt atgaaacaaa ggaatagaaa 42780 ttgtattcat attatacatt ttgaaattat atctatatta tattttttgt caaagcaaaa 42840 taaattatac attaaggaaa atatttaaga ttcaaagttg tcattttctt tctgttaatg 42900 agtatctttg atttaataac atttatagtt tggtcacttg aaatctatag tgaccaaaag 42960 caatgtcata tttagtagcc tcatttctgt tactatctga ttattactta agaattctac 43020 ttaattaata gattattaga acaaaaggca ttccaatttt agagattctt ttatggttaa 43080 agcactaggt aacttaaaaa atttggatca aatgttatac agattaatag accttggaat 43140 acaggggcta tgtctttttg gaatcagacc ttgtcctggc cttaattgca ggatgacttc 43200 cttattaaat ctctaaaagc aggaatgctc tggaacaatg aacaattaga atgtggtaat 43260 gtaattttgg gccaaaaaat actttgtaga aatgtgattc tcttacttgg aatagaaaga 43320 attctgactc gaaaaagtgc agttaatgta tgcttttctg ggtaagattt gtgatagatt 43380 ttgattgaga tttaaaacca tgatatataa atttagcttt tttgtcaaag taatttgcca 43440 ccctagaatt tgtgttggta atttttaatg caacttggac aatttctgaa agatgtaact 43500 ttcttttttt tgagacgagt ctcgctttgt tgcccaggct ggagtgcagt gacatgatct 43560 caggtcactg caagctccgc ctcccgggtt cacaccatta tcctgcctca gcctcccgag 43620 tagctgggac taccggcgcc cgccacccca cctggctaat ttttttttta tttttagtag 43680 agacggggtt tcaccgtgtt agccaggatc gtctcgatct ccggacctcg tgatctgccc 43740 gcctcagcct cccaaagtgc tgggattaca ggcgttagcc accgcgccca gcctgaaaga 43800 tgaactttaa aatggggaag gatactagta aagccatttc ttactcatgt atacattttt 43860 ccctccatga aattagagca gccacctttt acatgacttt tacatgcatt tcagattttt 43920 gtactagcaa ttaaaatatc tactggatgt aaatcacatg tgcttaatgc tttgcttcat 43980 aatatctgtt gaagtcaatt aaaatataga gacagatctt taaattgaac atgttttatt 44040 tgggaagcaa gaattaaatt tgaggcatat acacagactg ggtgtccttg gtatctctga 44100 agaacaaaga gaagtttgga ggttatagaa aaaggaaaat gtgacattgt ttttccagaa 44160 agttctttgg cactagtaaa ttttggggag ttggaagctc tgatgggtta gtgactgtgg 44220 tgggtaaaac tagtcttaga gtcacaacag gttgtttcag tatctattag ataaaacagg 44280 ttttaggtta caataggcag tttcagcagc taggcttgca gaaaattaca ttcttagagt 44340 aatgttatgt gccttgagtg cttttttccc cttggccctt gactctgatt tagttgggta 44400 tgacaagaat tatcaattta tataattact ttttacatat tgaagctgaa taggttttct 44460 taaaacttgg aaatgggaaa tactgggtct tgtgaagttt tagtgtgaaa acgataacta 44520 gtctcttatt tcatgctctt tgtaacaagt ctacagtaat acctaatgta tctagatgac 44580 acctcagaac caggagggaa caaaaaagac ctctgagcag tcaaaataat gctataagca 44640 tgtattccag cttactttcg gcatttctgt ggagtgcagg aggccacatt ttgttcatag 44700 atccagtttg acaagcttgg gtactgagtt aaagtgaaaa tggtgtaaat aagtaatcat 44760 attcacatga cagtaggtgg aagtgacagc tgacaatctg aaagagtgga caaaactata 44820 aaaattagaa ctaagaactc ttaaaataga acggtttgaa gtttgttaca gaagggagca 44880 gctttatgct tcagtggact ctgaaggtat tggcagtgta tagtactgct tagtcattga 44940 tttaaattcg gtatatatct cttctattgc tgtcatgtac ttgacattct gctgggtgct 45000 aaggctgtct gcaggctact aatatgcata ataacaatcc tgaaaaagaa ggaaaagtat 45060 actgtgcctt actgaagaag gcaggacagc cgttggtatt tgttagagta aatattagtt 45120 atcttacata aagcatgtta tattccctga tgtcagggcc tgataaatga gcccttacac 45180 tcttgatagt caatctgtgc cactgttgct gtgtttgtat gttacaccat ttcctgtcca 45240 tgtaacagtt aaactgtatc acatatctgt tcctactaaa ctatttgcat ataattttaa 45300 catttgagtg gctgtatata aagctaaaag ttctttataa gatttatagc atcttagaat 45360 gtttaaatta gataacatta gtgtgctttt agtttttgaa tttaattttg ctcttgattt 45420 tgtttgtgtt aatgtagact ttgtctacgt aagcttgagc ccaactttgg agtggtgttt 45480 tcagtgatgg aagtaactgg aaataactca tgaaaccact tagtactttt gatagtttat 45540 tcccatgaag gatcaaattt ttacttgagt cattaatata aaaatttaaa agacatgtca 45600 gattttatta agcatggatt ttaaatatat aaatattaga agacctaaac aaaatcgcta 45660 atgaaagagt aaaacatgtc cctgcctatc atactccctt cactttcact gatttctgct 45720 tttatgaagt actttaataa gctctacaac aaataaacaa gacattgtgc ctcattttac 45780 actctagcag tggttttcca ttccaactaa ctagattggg tttataatat agtcatttaa 45840 acttacttag ttaaaatgtt atacattagc aactgcaatt aaggagctaa gaaattcagc 45900 tcgtatttat ttatatgcat cttatccata gtttctcact tgttatattt gcctactgat 45960 ggcaaattga ttttttctgt tccaaaaatg tagtgttttg agatttttgg agatgcaaaa 46020 cagcatcatt ttcaaattag atcacaaaca atcttacttg ttgcagttga gactagtaat 46080 tgatcagtga ggtgaaaaaa ttaggcaaaa cggtatcatc aaaattttct ttcttttttt 46140 ttttgaaaca gagtattgct cttgtcgccc aggctggagt gcaatggcac gatctcagct 46200 cagctcactg gggcccctac ctacgggatt caagggattc tcctgcctca gcctcctgag 46260 tagctgagat tacaggcgca tgccaccaag cccagctaat ttttgtattt ttagtagaga 46320 cagggttttg ccatgttggc caggctggtc tggaacttca gacctcaagt gattcacctg 46380 cctcagcctc ccaaagtgct gggattacag gcatgaacca ccgtgcccgc cccaaatttt 46440 cttttaactt aaagtgttaa tgtttgtttg ttcccaatat ttttatatat gtcaaggctt 46500 tttcattata tacaggccag ctctttggag ttctgcatag tgtttcttgt ttaaaccaca 46560 cctataatgt accatctaca atttccaatt ctttaagaca gagtgaaaaa ttaagacacc 46620 tgaagcaatc tgagtgcgga gtcctaggca ttatgatttt ccttgacact tttagggttc 46680 ttttatcaca gtttatcaaa cacctttttt tttttaacaa aaaacaaatt tacaaaatct 46740 ttccatgtat tcaacttaga atttaatgaa atagggtttt tttttttttg gtggtcatgt 46800 atcatcaact ttctttacat ttaattaaat taatcaacaa aaaacatata gttgacataa 46860 acaaatttgg gaccaagcac tactgactct tagtaaacat acaagtcaac tgttggtgca 46920 gaagtgcctt gatgctagag agtagcctgc aagctgtaat tatatatggg cattagggaa 46980 tgaagaacag ccttaatact attgatcttt taagtgaagg tcagcttaga aagcttttac 47040 ttgttaaaaa gcttcacagt ttgtccttgt agttaatgca attgaagttg aattaatctt 47100 tcttaatttt ttttttaggg tttctatctt actaaaggat atttcagaaa atctatattc 47160 actgaggagg atgataattg ggtctactaa cattgagact gaactgaggc ccagcaataa 47220 tttaaactta ttatcctttg aagattcaac tactggggga gtacaacaga aacaaattag 47280 agaacatgaa gttttaattc acgttgaaga tgaaacatgg gacccaacac ttgatcattt 47340 agctaaacat gatggagaag atgtacttgg aaataaagtg gaacgaaaag aagatggatt 47400 tgaagatgga gtagaagaca acaaattgaa agagaatatg gaaagagctt gtttgatgtc 47460 gttagatatt acagaacatg aactccaaat tttggaacag cagtctcagg aagaatatct 47520 tagtgatatt gcttataaat ctactgaggt actaaataaa gaggaagcac atttttagtt 47580 attagtaggt tctggcagac tttattcccg taaagagaca gatagtaaat attttaggct 47640 ttgtgggaca tacagtctct gttgcagtaa ctcagttctg ttattgtagt gtgaaagcag 47700 ccacagacaa atgtaaacaa atgtgcctgt ctttcaataa aactttatct acaaatacag 47760 atagtgggcc acatttggct tgcgagctgt agtttgctgt tcctgactta gtatgatatg 47820 cagcattgtg tagtggaaag attttatagt atcaacagac atttgtagga gtttgctatt 47880 ttataatttc gtatgctttt ttcataatag atgtctctgc tttttgtgga ttctcttcat 47940 atctactagt gtttactctt ctgactttga tttttggggg tgtattttat ttctttatac 48000 agaatttttt tcttttttct ttcttttttt gagacaaggt tttgctgtgt caccccagct 48060 ggagtgcagt ggtgggatct tggccccctg cggtcttcaa ctcctgggct taagcgatcc 48120 tgtcacctca gcctccctag tagctgggac cacaggcctg caccactaca ctcagctaat 48180 ttttgtattt tttgtagaga tggggtttcg ctctgttgcc cagactggtc tccaactcct 48240 ggactcaagt gatccacctg ccttggcctc ccaaagtgtt ggaattatag gtgtgagtca 48300 ctgtgcctgg cccagaattt ctttacttgc tcatgtgaga gagtttctaa taaactcctg 48360 atgcttttgc ttgacactat agttttactg tcatctcaga gtcagatttt ttccttaatt 48420 tcttcattaa attgatttct taatttctca tttgttttgc attagtttac aaaattactt 48480 aagatgccta tattctctga aattttatat tttatttcac gataaataag tttaaaaaat 48540 tagatttgac catttaatta gagttatttc cccatcattt ttctaatggc aacaataatt 48600 ttagcatttg agcaattctc tgtattttgg taactattag taatcacttt tatcagtata 48660 aacatgcatt tcattttaaa atggttttca aaatattctc ataccaacca ttcataaaag 48720 atgttcccct tctgggaaat atcagttttt gctaacatct gcatttccct ttgattttct 48780 aggaatttct tattaggtat acactttaag tgatatgttt catataatat tataggatta 48840 tcaggatttc atgatttttt ttttttgaga tggaatctat ctctgtcgcc caagctggag 48900 tgccgtggcg cagtcttggc tcactacaac ctctgcctcc ccggttcaag tgattctcct 48960 acctcagcct cccgagtcac tgggattaca ggtgcccgcc accacacccg gctaattttt 49020 gtatttttag tagagaaagt gctgggatta caggtgtgag ccactgcacc tggccttgga 49080 tttcgtgatt tgactgacat cttttacacc aattattgcc atttttttat tgggtactaa 49140 ttattagtat tgctttcttt attcgttaaa taagaagtaa aagaactttt aaaaaataaa 49200 ataacttttt ttcctagtac aaagcttatt ttcaattttt tttattgctt aaattttgca 49260 ggttaattaa ggctgtactt ctttttccta cttcctgttt aaatatttgg cattttttga 49320 gggttttctt tctatggatt tttgtggggg atcccatctc gttggacact tggttcctgg 49380 agattgccaa attattgaaa agtttcctca tacccaaaca ttggcaatag actgaataaa 49440 taacatctct gacattattt ttcaattata tagagaatgc tttttgtaaa atactgattt 49500 atttaaagat attacaatca tagtagtttt ttgcaatctt ttttaaatca gtggatgtca 49560 aggaacaact attgttcttt gtacggcatt tttcaacatt gtgaagagtt cttatactca 49620 aaaagtttgg gagacacagt gtgacattgt ttaacctgag ttgaacttgt cattttgtat 49680 tcttgtttag agcagggatt ttattttgtc tctttatcta actttgtatt cctaactatt 49740 tctttctttc tctttggttc tttgtttctt tgttcattct tctctctctc ccttttttat 49800 ctatcatata aatatgtaaa tatatattat atatccatta gggaagagga agttgtctaa 49860 agatatctag tatataggag ctttgttctg cagaaaagag gatatgaagt caattatatt 49920 ggaaattaat gcttaatact ttttttaaag catttatctc ccaatgataa tgaaaacgat 49980 acgtcctatg taattgagag tgatgaagat ttagaaatgg agatgcttaa ggtatgttta 50040 caattataaa aatattactt caagttcttt ccaaaggaca tttaattaag taaaatatta 50100 actaattcta aactaggttc taccacaatg aaattgctac taattatgta acattagatt 50160 tcacattttc caattcatgt ttctttcatg tagtctataa ataatgggtt agaggtaatt 50220 tactaatttt aaatgtgctt tccttgttcc ttcttatttt ttattttgaa gacagggtct 50280 cactctatca cccaggctgg agtgcagttg ctccatctcg gctcactgca accttcacct 50340 cctgggctca agtgatcctc ctgcataagc ctcccgagta gctgggatta tgggcgtgca 50400 ccaccatgcc cggctaattt ttatagtttt agtagagaca gggtctcacc atgttgtcct 50460 tgctggtctc gaactcttta cctcaagtaa tccacccgcc ttggcctccc aaagtgctgg 50520 gattacaggt gtgagccacc acacctggcc ttggatttca tgatttgact gacatctttt 50580 acacaaatta ttgccatttt tttattgggt accaattatt agtattgttt tctttattcg 50640 ttaaataaga agtaaaataa ctttttttta aaaaaagaac ttttttccta gtaaaaagct 50700 tattttcaat ttttttattg cttaaatttt gcaggttaat taaggctgtg cttccttttc 50760 ctactttctg tttaaatgtt tggcattttt tgagggtttt ctttctatgg atttttgtgg 50820 gggatcccat cttgttggac acttggttcc tggagattgc caaattattg aaaagtttcc 50880 tcatacccaa acattggcag tagactgaat aaataacatc tctgacacta tttttcaatt 50940 atatagagaa tgctatttgt aaaatactga tttatttaaa gatattacag tcagtagttt 51000 tttgcaatct ttttaaaatc agtggatgtc aaaaacagct attgttcttt gtacagcatt 51060 tttcaacatt gtgaagagtt cttatactca aaaagtttgg gagacacagt ttgatattgt 51120 ttaacctgag ttgaacttgt cattttgtat tcttgtttag agcagggatt ttattttgtc 51180 tctttatcta actttgtatt cctatttctt tctttctctt tggttctttg tttctttgtt 51240 cattcttctc tctctccctt ttttatctat catataaata tgtaaatata tattatatat 51300 ccattaggga agaggaagct gtctaaagat atctagtata taggagcttt gttctgcaga 51360 aaagaggata tgaagtcaat tatattggaa attaatgctt aatacttttt tttaaagcat 51420 ttatctccca atgataatga aaacgatacg tcctatgtaa ttgagagtga tgaagattta 51480 gaaatggaga tgcttaaggt atgtttacaa ttataaaaac attacttcaa gttctttcca 51540 aaggacattt aattaagtaa aatattaact aattctaaac caggttccac cacaatgaaa 51600 ttgctactaa ttatgtaaca ttagatttca cattttccaa ttcatgtttc ttttatgtag 51660 tctatgaata atgggttaga ggtaatatac taattttaat tgtgctttct ttgttccttc 51720 tttttttttt ttttattttg agacagggtc tcactctgtc acccaggctg gggtgtagtg 51780 gtgccatctt ggctcactgc aaccttcacc tccagggctg aagtgattct cctgcatgag 51840 cctcctgagt agctgggatt acaggcgtgt gccaccatac ccggcttatt tttgtatttt 51900 ttgtagagat ggggtttcac catgttgccc aggatggtct taaactcctg ggctcaagtg 51960 atctactggc ctcagcctcc cagcgtgctg gggattgcag gtgtgagccg ccgcatccag 52020 ccctgtgttc cttcttgtgt tactttcttg taattttttc ctggaatatg ggtagtgatt 52080 tggctctcca gtattgaaat tgagtttcct ttcttccaat tcatgtgtat ccatttttat 52140 ttggaagttt tgtttttata cattcaataa tcatctttac tttctttggt attatttact 52200 atggatattt tatattatat aattttcaaa tggattaaat ggttcagttt tactcttatt 52260 attgagattg aaaatactag tttataattt atatattttc tattccttta cctctaattt 52320 ctttgtcagg tgttactaac caaagatgta taataagaaa agccaatgta gctaaattaa 52380 gtaaaaaatg aagaaaaaca cagaagttcc ccattatgca tttttttatt cctaatcttt 52440 aggttgatga gattttttta tttttatgaa atgagattaa tttattgact tttttagttt 52500 tgaggccaag taatgagtag tgagtaagaa tgtatattct agggccaggc atggtggctc 52560 actcatgtaa tctcagcact ttgggaggcc gaggcaggag gatcacttca ttccaggagt 52620 ttgagaccaa cctgggcaac atggcaaaac cctctctctc cagaaaaata caagaattgg 52680 ctgggtgtgg tggcatgtgc ctttagtccc agctacttgg gaggctgagg tgggaggatc 52740 acctggggag cctggggagg ttgaggctgc agttagccat gaccatgcca ctgcactcta 52800 gcctgggtga cagagtgaga ccctgtctca attaaaaaat taaaaaaaaa aaagtagatt 52860 gtgaattcag atgtaggttt gtatcccagc ttttccagtt agtatctgtg tgactttggg 52920 gaagtttctt agcatctttg atactcggtt aacagttgta attattattt aaggtattgc 52980 ttgagaagag cttagtatag agcctgacat ttagtaagtg tttaatacat attagctaac 53040 agtaaaacta gaacataaat actgaattgt attttgttat taattatcca tttctctgag 53100 aagtactgtt ccaatagtac atttatagga aacttgtgga cgtctacaaa cgtatacatt 53160 aaatctctta gaaggcaacc tggatgccca tattagagaa ctctatttta aacatgcatt 53220 ctaagtatgt ttgtggactt gaataaaata aaacaaacag aaacacttct ttcttctgcc 53280 ttcaggcttg aaatgaacat actttttttt aaaaaaaaac cttcaaaatg aaaatattaa 53340 ataaaagatt taataaaaag agaaagtaaa aactgtagtt taataaagtc ttcctgtctc 53400 ttcatagtta aaaaatgtta tagatgaaac aattttgaaa tattcttgaa atagataatc 53460 tttatttagg ggagaatgtc agatactgtc aagccaaaat aaaaacaaat aactttattt 53520 catgtttgta aaattccttt tctaaaatga tttgaatctt ttgttgtttt gacaattcca 53580 aaacacattt attgtttgct catagtttca gccttattca gaaagaatgc gactgacaca 53640 tgatatagag aaacttgttc caaaaataac attaaaatcc acgtttacta cttgagaatc 53700 gaaaatattg aggtgcaata aagaataaaa tgttttaaat tatccaaatt taaaatttat 53760 gatagctttc cccaggggca gtttattata tgctattaat gagccttgtt tatgctggaa 53820 atgttccatc tttggccttg cgccttagaa accattcatg agcacatatt taaaccggag 53880 cacacatgtt cttttgtagt atggcttgca catctgccag ctttcgacaa aattgtaggc 53940 cctgttaata atagtccttt tgtgtttggt gaaaaagata cgacactgtc agtggttttg 54000 cttttaagat ttcttttaaa ctttcagtct ttagaaaacc tcaatagtgg cacggtagaa 54060 ccaactcatt ctaaatgctt aaaaatggaa agaaatctgg gtcttcctac taaagaagaa 54120 gaagaagatg atgaaaatga agctaatgaa ggggaagaag atgatgataa gggtaagcac 54180 tgaagtatgt ttgaaatgac tcacctgtga tacctaccac tgactttaac ttaggatcca 54240 gttttggatg gtttggaggt cagggacttt gtggcatata gttaattatt ggatccttat 54300 aagcttttgt ctccttagtg cttttgtctc cataaagcac aatcttacta cttagaaaaa 54360 tagagtaata gcattatgat gataaaaata tctttccctt tgtttttttg tatttctcca 54420 aatcattata gctctcattt agaattatta aagctgagaa ctctaacaat gaacttttat 54480 tgtttagtgg ttaattatct tgattctttg ttttgccctt tcttggccac tcaggaatct 54540 ttcaagctca ctgtggacag ggaaagtgac ttgggtagag ctaacataac ttcattgtgc 54600 tgtgcagtta gaattttgac caaagatgtg ggtaactaac ttttcctaac taaatgacat 54660 ttaggtaact aaactaaacg agattttcgt aactaaattt tggtgtaact acatttagct 54720 ttaggtaact aaaacgaaga ttttatttta tctgtggatt tttttagtgc gggactaatg 54780 taatttctga ttaccattaa ttgaaggttg gttatattat aacatttgga ttggtatatt 54840 gcttgccatg gtttgttcta aatgttagcc tttagaagta ttcctgattc taaaacatca 54900 gtttttttta atagtcctgg caaagtgtga atcacaacaa aattctaata cttaaaagta 54960 atccaagtgt cacagatggt acccagaaga ccagtttgta ttggaattaa aaaatagaaa 55020 acattaaccc atggtagctg tcactgtatt ctttcaaaga agccaatgaa ataaactgtt 55080 ttctccctct atgtggtgtt tttctacttg aacataaatg cacattttat tttatttcca 55140 gactttttgt ggccagcacc caatgaagag caagttactt gcctcaagat gtactttggc 55200 cattccagtt ttaaaccgtg agtataatct catttaatca aatcacatat ttagtattct 55260 ctttaaaaca agggaaaagg caaataacct gtctgcttaa cagcaacagc acaacttcac 55320 tatagttata catgccacac tgtattttct gtgtgactac aaaattattt caaagtgata 55380 tttatataaa attcatttct gcaaattgtt tttataagtg aggaaaaatg gttttccttt 55440 aactgagcag ttctgagtag aaactagttt aaagatactt ataaataaat gttaatttaa 55500 tactgacttg tttttcatta aacgagtgtc tatgtgcctg ttttgtgtat attacccaga 55560 acatgcagat gtactagaag ttcttaatac aacaatttga ggaatagtga taatcttatc 55620 tattttaatg tactcaaaat ttgtttacat ctaacaggca catttttgtg aggattaaat 55680 gagatgaata agaatgagat gaacaagtaa atgtgaataa aactaataag cctgtgaaaa 55740 tctagactgg atttttccta ttctgagaat ttaaaatata atccactgaa gtatttcttt 55800 ccttttttct tttgatctta aacatttttt atttatgtct tacatacaga aaagtgcaca 55860 tgttgtagag atcaatgaat tgtcataaac tgggcaccct gtggccagca cttagttaag 55920 aataggtcag taacagcatg ccagaagacc acctctccaa ttgatttttc ccatgatatt 55980 ttattaagaa aattttctaa gatgtagtaa agttgaaaga acttttttct gtgcatgtct 56040 gtattcccac cacctaaatt caactatcat tactatactt gctttatcac atatccatcc 56100 attcatatgt ctctatccat ccattcattc attccagttt taaaatgcat ctcagggtca 56160 atcgaggaca ccattacact tccacctaag tatttcagca tgtaaattat taacgagtta 56220 aatatttact taacagtttt ttctttggtg taaaatttgc acgtaaggaa atataaaact 56280 ttaagtgtac atttgcaaat tttaaatata catgtgcata cccatgtaac ccaaattctt 56340 atcaagagat attattatca tcaccacaca gagttccctt atttcccttt tcagtcagtc 56400 cttgtccctg agcatttctc ttattatttt aaagtattga ttcttttgga tatctagtat 56460 gaagcttaga atctgttttt tactttagat gtatgtagtg aaatttaata tatataccaa 56520 atggtagttg ttagttagct tgaatgggac attggtcaaa tggcattgtt tgttttaaag 56580 ttccaggttt gtgcatttat gtatgaagtt tgaaaataaa ttctatgaga ggaaatgaaa 56640 aattgaatgg attttaattt gtaccttggg tttcttatta ataaaacaaa atagcttttt 56700 gcttttcacc ttcaagagtt cagtggaaag tgattcattc agtattagaa gaaagaagag 56760 ataatgttgc tgtcatggca actggtaagt tgtacttaag caaaacctaa tcctttaaaa 56820 aaataaaaca taaagagttt gaaatgctta atctttcatt aaactctcaa aatacaaatg 56880 caactacaaa tgatgtaaac tatagaagag agtgaacaaa gaacagatgc tcagatttat 56940 gtatcaatta gcttttagga agatagcata ctagtattga ccattcatct gtataagtac 57000 attgtaaaaa gaaatgaaag catcaaaggt ttatttttat ttctatattt ttttcatttt 57060 atttttatat ttttttcatt tcaaggatat ggaaagagtt tgtgcttcca gtatccacct 57120 gtttatgtag gcaagattgg ccttgttatc tctcccctta tttctctgat ggaagaccaa 57180 gtgctacagc ttaagtaagt catgttatca ttgccacaat atcaccctct ttttttcttc 57240 tgtgggtgaa acatctgatc catcatgcat gttaaaatct agttcacaat aacacatttc 57300 tgcaggtatt gctttatctt tattggtaat aaatgaccct ttagtggaag agcttacctt 57360 ctttcttgtg ttctctgtaa ttcaaagcta ccaggtggcc ctgataaaat ttttttaaaa 57420 aacattatta ctttatgctg gtttacattg aatatctcaa aattcttttc tctttttgtt 57480 acccttgctt tttagcttga taagaagtgt atacatggaa gtatattttt tatctatgaa 57540 acacttttca gcttcttcaa cctgagcttg caatctgttt taaattgata cataatatct 57600 ttacatattc atggggtact gtagtatttt gatacactca tatcaaatac acttgatcaa 57660 atcagggcat ttgttcatca acttgaacat ttatcatttc tttgtgctgg gaacatttct 57720 aatcttttct ttgagttatt ttgaaataca cagtgttgtt gttaactata gttaccctac 57780 tgttggttaa tgagtacaaa catacagtta gaaggaatag gttctagcaa cctattcctt 57840 taccccctgt catcccctgc tgccctgagc ttgcagtctc tttcaaagac ccaccttaaa 57900 aacttgcatt ctgataaggc ccttgaagga atttgcttat caagttagta agtgacaaaa 57960 aagaaaattg caaagaacag gaatataaat tattatattt ctttattctt tctcacttaa 58020 gagtgaaatt gatatgtgta atgtgtacat ggtgccagaa tatttgtttt tcttcttata 58080 gaatgtccaa catcccagct tgcttccttg gatcagcaca gtcagaaaat gttctaacag 58140 atattaaatt gtgagtaatt tttttccctc aacttttatt ttggatttat gggggtgcat 58200 atgcaagttt gttacgtggg tgaattacat gttgctgagg aagttgtgag taatttatgt 58260 catttctaat catgtggtca gatgtctgtg gtatatgaga gaattttgta tacaaacaaa 58320 ttttactaaa tgcatgaaaa aaaaagtcca tgattttaaa atgcactttc ttttgtacct 58380 ttgcaggact gttacttttt aaatccttca aacttgaaga aatctgttat tctcggttct 58440 tgggctataa gattagcatt gtactcatag aattataaaa attttggttt tggaagagaa 58500 gttggagaat ataaagattt gtctcatttt atagatgaga aaactgaggc tcagagacaa 58560 gtaatttgcc caaaatcaca caatgactgg ctgagcaggg actggattct aggtctcttg 58620 cccaaccaat tctatcatga tgtaattcct aaggagaatg tcatctcaga tacacataca 58680 cacacccatt ttgtgtgtgt gtgtgtgtgt gtatatgtac acacacacac aaacatatgt 58740 acacttatat atacatacac acacatatat taatatatat gcatatatat gcatgttcta 58800 attcagaaca ttttcatcac tcccaaaaga acacccctgc ccattaagca gttgctttct 58860 ttacgtatat attagtatat acatacacac gagatacaca tatatttact gagttttgat 58920 aaatgcatac aaagatgtaa accaaacctc taacaagata cagaatatca ctgacactct 58980 agaaagtttc ttcatgtccc tccccagtct gtccttccat cctccatcct aggcaagcca 59040 ctgctccgat tttctctacc atagtttggt agaatgccat ataaatgcag tcacacaata 59100 ttaactcttt tgtgtaagac ttctttcatt tgctgtaatg tttctgagat tctttcatgc 59160 tgttgcatgt atcagtagtt ttttgttttg ttttgttttg tttttgtttt ttcagagtca 59220 gggtctcctt ctgtcaccca ggctagagta cagtggcgca atcatagctt actgcagcct 59280 ctaactactg ggctcaagct atcctcctgc ctctcaagta ggctaggctg caggtatgtt 59340 ccaccatgcc tggctaatta ttaaattttt tgtagagaca ggatcttgct tggttgccca 59400 ggctggtctt gaactcctgg cgtcaggatt gtttccagtt ttggattatt acaaataaag 59460 ctgagacaca tataagtctt tgtatggaca tatggtttca ttttattgat acatgtcaag 59520 gagtgggatg actggatcgt gtggtggata tatgtttaac tttctttttt ctgagataaa 59580 attagaaggc gatcctcctg ccttggcttt ccaaagtgcc gggattacag gcgtgaacca 59640 ccgcacctga tgcagttgtt gttgttgttg ttgttttaat atctgattat tattttattg 59700 tatttcattg aatatagcac agtttgtttt tacattttct tattgataga cacctaggct 59760 atttttctgg ttttggactg ttactaataa agctgctata cacatcctta taaaaatctt 59820 ttttgtgaac atgttttctt tttttctaag cattttaaat cacctttatt gaggtgtaat 59880 tgacttacaa taaattttat atgctgagaa tgtataattt gataagtttt gacacaggta 59940 tgcactcatg aaaccatcat cacaatccag ataatgaaca tattcatcac ccacaaagtt 60000 tacctttttg ttttaacccc agtcaccggg taactgctga gctccttcct gttactgtag 60060 actagtttgc attttctaaa cttatataca tggagtcatt catattttat gtgctctttt 60120 ttgtctgatt taaataatgc agtataatta ttttgagatt cattcatgtt attacagtga 60180 ttaatagttc attcctctta ttgttaagtg gattacattt tatggatatc caacaagttg 60240 tttatccatt cacctgatag acatttggat cgtttccagt tttgggttat tacaaataaa 60300 actgctatga acattcgtat gtaagtcttt gtatggacat atgttttcat tttattatat 60360 atgacggagc ggaatgactg gaacatgtga tgcatatatg tttaactttc ttttttctaa 60420 ttgagataaa attcacagaa cataactttt accattttaa tcattactaa agtccagtgg 60480 gttttggtat agtaataata tataaccatc ataattaatt ccagaacatt ttcctaactc 60540 ccaaaagaaa ttccataccc attaaggagt cattccctat tttccctttt cttttctttc 60600 tttttttttt tttttgagtc agggtctccc tctgtctccc gggctggagt gcacttgcat 60660 gatcttggtt cactgcatcc ttgatttcct gggctcaatt gatcctccca cctcagtctc 60720 ctgagtagct gggactgtag gcatatgtta ccatacctgg ctaatttgtt ttattttgag 60780 tggagatgag attttgctat gttgcccagg ttgctctcaa actcctgggc tcaagtaatt 60840 gtcccacctc agccttccaa aatgctggga ttacaggcgt gagccactct gcccggccta 60900 ttatctctgt tctgcccact tccaaccact aatctacttt ctgtctctat gatttgccta 60960 ttctggatgt ttctataaat taacttatac attatatggc cttttgtgtc tggcatcttc 61020 cacttagcat agtgatatca gtacttcatt cggtcttttt ttatgactga ataatattcc 61080 atagtatggg catacacatt ttaaaaattc attcatcagt gatggacatt tgggttgttt 61140 cctttttggc tgttatgaat aatgatgctg tgaacatttg tgtaccaatt tttttatgaa 61200 catacatttt caacgctttt gcatatatgc ctaagagtgg aattgctggg ctatatgcta 61260 attttttaag aaactatgaa gcttttgaga gtgattgtat catgggatat tcccaccagc 61320 agtgtatgag aggtccagtt cctccccatc cttgctatca cttagtctgg ctgatcttta 61380 acttaagcca ttctaatagt atctcattgt atttttagtt tgcttttccc taatgactaa 61440 ttatattgag catttttcat acacttattg gccatctgta tatcttcttt gagggagtat 61500 ctgttcaaat cttttgccta ttttttctta gtgagttttg atagtcattt ctatattctg 61560 aatataaatt atttatttga tatatgcttt gcaaacattt tctcctagtt tatggctttt 61620 catactttcc acacagttct tttgaagagc agcagttttt cattttgata aagtccagtt 61680 tgtcgattcg ttcttttagg gattttgctt ttagtgtttt gacccaaggt cacaaagatt 61740 tgcttttatg ttttctccta aaagttttat agttttaagt tttacattta gatttacgat 61800 tcatttttag taaatgttgt ctattgtatg aggtattgat tacagtttat gtatttttca 61860 catattgttc cagctccatt ttttaaaaag actatgcttt tacactgaat tgactttgta 61920 cctttgtcaa aaataaattg actacatata tgtgggtcta ttgctgcact ctctattctg 61980 tgttctgtgg atctatttgt ctgtcttgat tggtgtcttg attactgtag ctttataata 62040 aacctggaaa tcaggtagcg caaggcctct tgctttgctc ttttctttca aagttgttct 62100 ggctattcta tgtcctttgt atttctgtga gcatgtcagc atcacctttt caacccatat 62160 gcctgctggg attttgaatg agtttacctt gaatctagat atcgaaacaa ttagctgtct 62220 tgatagttat tgtcaccgtt ttataccgaa gaaactaggc atactaaagt aacttggcta 62280 acatcactta ccttgtaaga agtagaactg ggctgtttga catcagagct tattctttat 62340 accatttcct atgttaatta gaatacaata ttaatttcat aaaggtaaag gcatatctgt 62400 tttgttccta tttgattcct tgtgaaagca caatgcctag cgcacaatag acacttaaac 62460 ttatctgttg aatggacagg tgaatgcttt taaagtcttt ccatatagaa aattaagttt 62520 cattacattt gacttgatct aggttttcat ttcatagaat ggagagcaga ctctgtaaat 62580 attttgcccc agacctagct ttattacaaa cattgtctta attaggattc tgtctaccca 62640 gaatagaaat taactcaagc tagcatgagt gtatattgaa atttatatta aggataaagg 62700 aatgtctcat agatcccact caaaagaaat tagccagccc ttaggaagag actggaattg 62760 ggtttggaaa atacaatagg tctttctttt tatctgtagt ctttagtgag tcttcctcat 62820 ttttctctct gaagagataa gcattctctg catatatata gcattctttt agattttcgt 62880 gacataaagt attatttaaa ctttcataag gtatcttgat tttaagttgt aattccttga 62940 gatgattgtt ttctttattg ttaatatgtt tcccttcctg tttttttttt tttctttttt 63000 cttttgtttg tttttacaga ggtaaatacc ggattgtata cgtaactcca gaatactgtt 63060 caggtaacat gggcctgctc cagcaacttg aggctgatat tggtaagtga taaagaaaga 63120 tctctgtaaa tacttactga gttaatattt aaagttaaac ctatggatgg acactggatt 63180 tcacttctgt taaagtttat ttcaaacatt acttcctcca ggaaatctct gactctctaa 63240 cttgctgttt cacctatctt atcccatgat actctataat tccttttgct atagaaatta 63300 ggctctgtta tcataattac ctgtttatat atctgttttc ttctgctagg ctataaactt 63360 ttcaagggaa aaatatcact ttttaaaatt tatgtttccc cagtgcagtg cttggcatat 63420 aggcacttaa acatattgtt gaatgaatgt tgaatcctag gttctgtgaa attttaattt 63480 acttgttttt catgttctgt atctaaatta agtcagtgta gtggttttgt accctctttg 63540 ttcataagaa tcacttttca aactttaaaa aaaatgtagg taaccaacac ccaactctga 63600 aaattctgat ttaacaggcc tgggttggca cctggcattg gtggtttctc acaggtgatt 63660 ctgatatata gcccgggttg gaaaccacag tacctttgat tagttgccac tagtgagtat 63720 gatttattac aaaaaccaaa aacttagata agtcacagtt tatttcctag aacgtgtaaa 63780 tatagaatta gtcaaaagct gatagcactt tttttgtact taaaaatatt ttaagcctca 63840 gtatagtgag acctcatctc tacaaataat tttttaaaaa attggccgag cctggtggtg 63900 catgcccata gtccaagcta cttgggaggc tgaggtagga ggattgtttg agcctgggag 63960 atgaaggctg cggtgagcca agatcatgct actgcactcc atcctgggca acagagcgag 64020 accatgcctc aaaaaaaatt tttttttctt cttggtggtt aggcttaact atccaagaat 64080 tgcaatcatg gcttctattg caaatgcccc tatttcccac cttcagttgg cctaaccaaa 64140 tttaattttt caatatcata tgatcttttt gtataattat gtattcaaat aattccagat 64200 aggttaggtt ttcgaattgc aacgtctcat ttaatggtta ctttcatata actgtaggaa 64260 agcatttgat aatttttcca acaatgtaat gaaaacaaac ttgtatcttt tttattatgt 64320 gttaaaacca acaaaagaat gagggcagca attaacattt cattaaatat attagcaatg 64380 agtacattta tgagctctta aactccctta ttgacatact gtattttttg cctttaatgg 64440 acaatgaatt tgatatgttt cctaataggt tgtatgaagt tattgtgaat atttcacttt 64500 ggattaagaa taactaccct atatataaat ttcatggttg tattgcaaaa gctggggtct 64560 atgtccatag tggtttgggt acgtttttac tatttgcttt gtttctgtga tagtgttaaa 64620 tgaataataa gcttaagtat ttaagcaaat acttaatact tctgacaagt agttagaact 64680 ctctattttt gtttttttgt aatggatgag ttatggacac tgcaattatt agagcagcgt 64740 actttgctta tgatggatga aaatgttctc tggttgactc agtgttgaat aaaaagggat 64800 acatgaaata aaaattattt ttgaaatatt ttcctttgcc ttttgttgcg ggaaattgta 64860 caatgcttgc aaaaatgaat atacgcagga tattatttgt acagcagtct gacatttagc 64920 taatcagatt cctcattttt aggtaaatgt taaattactt aagtagtctg gatttttaac 64980 agaaacagca aacatagttt tatagggagg ctccttacca accagacttt taacttaagt 65040 gaatgttggc aaaagcttgt ctaaactgat ttccagggat aaggtttagc tccattaaaa 65100 gctagtttgt caaacctgta actaaagctt tttaaaaaat gaaagtttta aaagagacca 65160 tcattctgtt ttaacctatt taatttaaaa tctgggctga agtaggagta ttgcttgaac 65220 ccaggagttc gagaccagcc tgggcaacac agtgagaccc catctctgaa aaaaaaaaat 65280 gagctgagca tggtacctgt tacagtgcta gttatgaaag aaagaaagag agagagagag 65340 aaggaaggaa gggagaaagg aaggaagggg ctgggagtgg tggctcacac ctgtaatccc 65400 agcactttgg gaggccgagg cgggtggatc atgaggtcag gagatcgaga ccatcctggc 65460 gaacatggtg aaaccctgtc tctactaaaa atacaaaaag aaaaaattag ccgggcatgg 65520 tggtgggtgc ctgtagtccc agctactggg gagggtaagg caggagaatg gcatgaaccc 65580 gggaggcaga gcttgcagtg agccgagatt gcgccactgc actttagcct aagaaaagga 65640 aggaaggaag gaaggaagga aggaaggaaa aatcagtcac tcactcaggt ttagtttcaa 65700 aagccaaaac agtgataata ttgaattttt tccagccact cagtagtacc cagagaattt 65760 tgatacaaat aactgacttt gaccccatgt ttagtaggtt ttttttttgt ttgtttgttt 65820 gttttttttt tttgtctttc ttctccacac tctcttagga ctgttgtagc ttgtaatgtt 65880 agtgaattgt aattgtttat ttgcatgtct gtctcctctt ttagaattgt gaactcctca 65940 ggtcatggat tgtattttat tagtcttttt attcctagaa aagtgtttgg ataataatag 66000 atatttatta accataatag gagtagtagc atttttgtgt gtgtgtgcca ggccctattt 66060 tagcatttta tgtgaatgat ataatttaat ttttagagca tctagaaaat gttaggtacc 66120 attattatcc acattttact tgtgagagga ctgagacttg gaaagcttaa gtaacttgct 66180 taaggtaata cacatggcag atggtggagc caggttctgc atctgggcag tctgacttta 66240 gagcttttta atcatcctcc tcctagtgtc cgaacattat taatgctcag agaagtatca 66300 aagaatgatg atactcattg agggaaaaaa ttattcttaa gtatcaattt gttaattgag 66360 gacaaaagca ctactgttac tactgtgaaa aatctgaaaa cattgtcacg gatgatttta 66420 caataacatc cttttctgac atgcattaca acacactatt gattccgttt caatgtttgt 66480 gtctggtatg ggggcggagt agagaggcta ctacaggaag aaagaacaaa taacatttct 66540 tcttactact ttgtgcatca tgtgatttag ctcctcccat accattttac attagaaaat 66600 gtggctgtcc tcctgtgctc tagtactggc atttcagagg actctttgca atatgatatg 66660 tgatcaatca tggatggcga tgcagttaat ttcagtagaa atttgctgac tctttttatc 66720 tcttttaata gctaatgcat gagataaaat tgaaggtatt accaaggaga aatgcaggtg 66780 gatagttttg gaggcaaagt cacagtaagc aattcatctc tccaaggaat agtgatgaaa 66840 gctgagatcc aataaatgtc ttgtttggat taatacataa atatttcctt ttaaaattct 66900 taaggctttt attcatatat ctcccctctc cctatttcca ataatgattt ttggtgttaa 66960 tatgatgata tttatgcttc tgtttttata ggaaccaaat actttgattt ggttatttat 67020 tctcctttgg agatgtagat gagtttattt tttcctttcg agctttatct tttcctttat 67080 gtgtttttct ttttttacag gtatcacgct cattgctgtg gatgaggctc actgtatttc 67140 tgagtggggg catgatttta gggattcatt caggaagttg ggctccctaa agacagcact 67200 gccaatggta agctttgcca agtctgatgt cccgaaatta cattcttaat aaggagagca 67260 ttcaggattg gggagtggta aagaagctga agacttcact ataaaagagc aaatggataa 67320 tgtaaaaaga gaactatttt tttaaaaatg ctaaagttgg tatataatct attgaggaat 67380 ataatagaac aaggcttgac aaaccttttc tgaaaggacc agataataaa tatttcaagc 67440 tttataggcc acatgtagtc tgtatcacat attcctctct ctgttttttc ttttagtaac 67500 cctttaaaaa tataaagagt tacatttttc actggtgggc cataacaaaa caggctgtgg 67560 gccatatttg tccgaatgtc ttctcagtga tctttcatcc gtatgtcctt ttactctagg 67620 atgctgtgaa atcctggtta ccccttcttg tatcacattg aaaacctaaa gtttgaacta 67680 ttctatagaa attttattaa agcttttggt attagaattt ccctttcttc cctaattata 67740 aaaaatagca aattttggcc gggcatggtg gctcacgcct gtagtcccag cactttggga 67800 ggccgaggtg ggtggatcac ctgaggtcag gagttcgaga ccagcctggt caacatggtg 67860 aaaccctgtc tctactaaaa atacaacaat tagctgggcg tggtggcagg tgcctgtaat 67920 cccagctact tgggaggctg aggcagggga attgcttgaa ctcgggaggt ggaggttgca 67980 gtgagccgag attgtgccat tccactccag cctgggcaac aagagcgaaa ctctgtctca 68040 aaaaaaaaaa aaaaaaaaaa aaaagtgaat ttttacatga atattctaca tgattggcat 68100 atttacatga atggtttaaa aacccacaat aatagcactg ttttattttt tattttgaaa 68160 attgtagatt cacaagaagt tgtaaaaaaa aaaataccta tatagaggtc ctatgtacct 68220 ttcatccagt ttcctgaaca gtaacatctt gtgtgactat agtacaatat caaaactagg 68280 aatatgacat ttgtacagta tctagagttt attcctattt ctctagtttt gtaagtactc 68340 ttttgtatgg catgtgtatt gttctataca gtttaatctc atgtacattt gtgtaactac 68400 cactgcagtc aggatgccaa atgttccctt accacaaagc tccctggagc tgttcttccc 68460 acccctggcc ctagccactg gcaaccacaa atctggtctc tatctctaaa atattatttc 68520 aagaatgtta tatacatgga atcatgcaat ttgtcacctt ttggaattag tttttttcac 68580 tcaacataac taccttgaga tctatccaag ttgtttgtgg tcatgtgttg cctaacaaca 68640 gggatatgtt ctgagaaatg tgttcttagg acattttgtg gttgtctgaa catggactta 68700 cacaaaccta catgataaag cttactgcac acctaggcta tatgatagag cctattgctc 68760 ctaggctgta aacctgtaca gatgttactg taatgaatat tgcaggcaat tgtaatacaa 68820 tggtaagtat ttgtgtatct aaacttatct aatgtagaaa agacacagta aaaatacagt 68880 ataaaagata aaagatggta tacctgtata gggtgcttcc tgtgaatgga gcttgtagga 68940 ctggaagttg ctctgagtga gtgagggagt ggcgagtgaa tgtaaaggcc taggacatta 69000 ctgtacacta ctgtagactt tatacatatt gtacacttag gcgacactaa atttttaaaa 69060 ttttctttaa aaattttctt tcttcaataa taaattaatc tcagtttact gtaactttaa 69120 ttcataaacc taaaacattt tttgactttg gactcttgta ataattctta gattaaaaca 69180 tgaacacatt gtacagctgt acaaaaattt tttcttcctt gattaatgca ttccataagg 69240 ctttatttta aaattttatt atttttattt ttaaaacttt tttgttaaaa actaaaatac 69300 acacatatca gactagacct acacagggtc aggatcatca atgttgctgt cttccacctc 69360 cacgtcttat cccactggaa gttctttagg ggcagtaaca ctcatggagc tgtcatctgt 69420 gataacaatg ccttctccta gatacctcct gaaggacctg cctgaggctg tttttcagtt 69480 aactttaaaa aatgaatacg taggaggagt atactctaaa ataatggaaa agggtatagg 69540 taaatacgta aaccagtaac atacttgttt attattcatc aagttatata ctgtatataa 69600 ttgtatgtgc tatacttttt aatgcctggt agtgcagtag gtttattgac agcagcatca 69660 ccacaaacgt gagcagtgcc ttgtgctaag acattatgct ggctatgaca tcacttggtg 69720 ataggaattt ttcagctcca ttataatctt atgggaccac tgttccacat gtgctctgtc 69780 attgacagaa atgccgttaa gtaccacatg actatttttc ggtggtctgt tcctttttat 69840 tattacagag tattccacag tatggttgta ccacagttta actgatcacc tgttgaagaa 69900 cttttgggtt gttttccagt ttttgactat tatgaataaa gatgctatga acatttgttc 69960 atatctcaaa ggttctttat ttttttttat ttatttttct ttttttgaga cagtctggtt 70020 ctgtcaccct ggctggaatg cagtggcgcg atctcggctc gctgcaagct ccgcctcctg 70080 ggttcacgcc attctcctgc ctcagcctcc cgagtagctg agactacagg cgcccgccac 70140 tgtgcccggc taattttttg tatttttagt agaggcagcg tttcaccgtg ttagccagga 70200 tggtctcgat ctcctgacct cgtgatccac ctgcctcggc ctcccaaagt gctgggatta 70260 caggcgtgag ccactgcgcc cggccttcag agattcttta atgggtgaat ggttaaacaa 70320 cctgaaaata taaaagtttt catttctctg ggataaatgt ccaggagtgt atttttagtt 70380 tttaaggaat tgtcacaaac ctgttttcca aagtggctgt agcattctac attcctgtca 70440 gcagtgtgtg aatgatctag ttatccttgc caccgtttgt tgttgcaact gttttttatt 70500 ttagccattt cgataggtgt cgagtggtat ctcactttta atttgcattt ctctcatggc 70560 taatgatggt gaacgtcttt tcatatacta atttgcctct ggtgaaattt cttacataat 70620 tggagtgctt gtttttttct gttgagtttt aagagtttaa aaaatacatt gtagatatga 70680 gtccttggtc agatacgtgg tttcaaatat ttctttcact ttgtagcttg ccttttcatt 70740 ctttttaccg tgtctttcac agagtaaata tttaacattt tagtgaaatc cagtttatca 70800 ttttttcttt tatggattgt gctcttcacc tagccctaga tcctgaagat tttctcctgt 70860 ggttctttcc taaaattgtt acagttttat gttttaagtc tgtgatccat tttgagttaa 70920 attttgtata aggtgtgagg tttaagtcaa ggttcattgt tttcccaata gattaaattg 70980 cagcagatcc tttgttgaat aggctgtcct tcccctgtta aattgcgttt gcccctttgt 71040 tgaaagtcat gtgggtgtat ttgtgtgggt ctatttctgg gttctctagc ctgttatatt 71100 aattttgaac gaataaagtt ggcttatgtt taagttttct tggtagtagc gaggcaatgg 71160 tgccttctga gcccaggatt tcacaatttt gtgagtaaac tgtgttagaa attgtttgtt 71220 attcttttgg taggttgtct agttcaattt cattgctcat taatcttgct tatagatagc 71280 aaattgagag gcatctcaaa aatagtatct tttgttagct tatctcacag agtttggttg 71340 gagcagatat taaaacaaca aaccaaaaat aaattaaata tactagttag caagtttata 71400 ttgagggaaa atcaaaccat gtgaattgag ctccaatgat gtggctggcc ttgggtcaga 71460 ttttagtatc atggttcaac aaggtagcta ttaaaatctt catacttttt cttgaaataa 71520 ttctttagta gtcacatagg acagcacaca ctcatggatt tcttctttcc ttactgtctc 71580 tttattctca gcctcctgtt ccttctcatc tccctgacct tttaatgttg gccttccaga 71640 aactttagtc tttggaccta cctttgcact cattttcttg gtcatttcac ccaacataca 71700 gttttatgtt attttatttt ttttattttt gagatggagt ttcactcttg ttgcccaggc 71760 tggagtgcaa tggcgtgaac tcaccttact gcaacctctg cctcccgggt tcaagtgatt 71820 cttctgctca gcctccccag tagttaggat tataggtacg tgccaccatg cctagctaat 71880 tttgtatttt tagtagagat ggggtttcac catattggcc aggctggtct cgaactcctg 71940 acctcaggtg atccacctgc cttggcttgc caaagtgctg agattacaga tgtgagccac 72000 cacgtccagc ctacagtttt aaatatcaag tctatactga ggactcccaa atttttatct 72060 ccatcataga ctgatatcag cagtatatga gtgattcagt tgtttttgcc tctttgccag 72120 catttggtgt tgtcactatt agttcatttt agccatttaa tagaatatat gtacatatat 72180 atgtgtgtat acacaggcac acatctatat aactactcaa catgcctctg gtgagatgac 72240 caacaggtat ctcaaactta acctcttcct aattgacttc tgcatagcac tccagatctg 72300 ctctttcctc actctcctcc atcttgttta acagcagctc cattggccaa aattttggaa 72360 ttttcctcaa tcttttctct ttttcttaca ctccactgtt tatttaaaca gtaaggaaat 72420 ctcgtgaggt cttcagaata tatgcagaat taaatcactt ctctcttgat ccctgccatt 72480 ccccaggtac gggccaccat ctccttaggg cctcctgctt tcactcttcc catccctcat 72540 tctgtttcaa cacagcgtcc agagtgatac tttaaaaatg aagtctgata gatcatgtct 72600 tcggctcaga accatctagt agcatgccat ttcattctaa ataaaggcaa aagtccttat 72660 gatgagttac cgatcctcat gtaatctggc cttccatttt ccctctgatc tcattctcta 72720 ctggtctcct cattcaccgg atgcagccac accaccctcc ttgtttttct tcggacattc 72780 caggcatgct tcagtgcctg ggctttgcgc ctgctgcttc ctctccctga atacgtttcc 72840 cccacattgt ctataggatg ttctcccata cttctctcag atctcttgga tttaggcctc 72900 ctgggccacc atatttgaaa tatcagatta gttccccctc ccccatcatt cagcattcct 72960 cgtaaatctt tgctgtttta aaaatagcac tatcactgtc taacttactg tgttatattt 73020 tgttaatttt ctgtgagttc ttcttcacta gaatattctt tgtagggagg agtttttgat 73080 tgtttggttt ataaaatctg gaacaatacc tggcttatag gaggtgctca atttataatg 73140 gggtgaatga atgaatgaat gatgatgaga aagctgagaa tcagtaaagt gactttccaa 73200 aacaggtagt gggcagtata gagttgggcc ataaatagct gcaccataca acatcctgct 73260 agtttctaaa gcaaatgatt tgaaagaggc ataaaacata atttctgccc tcaggtagct 73320 catagttcag taaaggagtt tagattcata cctataacag tagaagtaat agcaccaaat 73380 gaaatatggt attatgaagt ggtacaaata atataaaaag atgaacagtg ttagtagtac 73440 atgtttagaa gggatttctg tggtgaaagt cactaggcac agtgcacctg gaggaccgat 73500 ttccattaat ttagaatggt ttaaagtaag cttttggaaa ctaggaagat tactttctgt 73560 aatcctttcc taggcctttg attctagaag gattgtgtta aaggagtttt aaatatttta 73620 tacagttctt aaacattgtt aagcttgaat taaatctttt attatgtctg gccatggacg 73680 tcattggatc attttcattt cttgggagga ttaataaagc acattccttc tgttgggcct 73740 ccagtgcggg gagggtgttg gccgagcagt ggctgagaaa acgtttttcc cctggtgttt 73800 tcaagaaccc tctttattag ctaagtggtg agacatgcca cctggtggtt atagtagtat 73860 catttttctc actgttcttg gtgcttttct tctcgttctg attccagtta tactaggaca 73920 actgctataa acctggaatg tttcacacta tattatttca gtaatttcaa aaacagcaga 73980 aatcactaag ctgtttggca caaagattcc tatttggaag gaatcagaca aagtgagtgt 74040 tgagaaagaa cagccaggca gaaagctttg catcagtctt aaagttcttt acatttcaag 74100 taagaggaat tgtgaaatcc ataagacatg tggggttttt ctattacttt ctccccagta 74160 tctattacaa agatcagcac atagtaggta ctcagtaact atttagaatg agtgcatgaa 74220 tgaatgaagt atgtgtgatg ttatggagta caaagttaga attagcaaca tgacctgaat 74280 ttagaagcag gtgggatact tatacttttc tcagtctgtg ggcaccacac cattgaagta 74340 tatgtctaag attaatttat atttggttgt ttgatttagc aaaacttgct gcctgttaaa 74400 aaagaaatta agacctgtca acttaaagaa tacattttgt gagttaagaa ctaaatgaca 74460 gtataattta ttacccaaag cagtttgctt ctgaaaatta aagagttcaa gctattaata 74520 attatgctgt gactgcaggc ataaactggg aatgtcctgg caaatgagga tgtattgtca 74580 cctttctcag cctgcctgtg tgttgttttt aagcttcact ctagtttata tattttaaat 74640 gtcataaaat accacatact tataagagaa aaggttctat tcattgctga agtggaagct 74700 tatcattaat ttttatttat ttattttttt ttccagtttt ggaattctta ttactttgaa 74760 cccaagaacc actgataact agcacaatcc agtgaaacag aggaagcagc agcttaatca 74820 aaggaaaaat acatttaaga ttataagtct ggttataagc ttaaaaagtg acccagaaag 74880 ggatatcatt gctaaaaaaa aaaatcccct tgtgacctgg gtacattttg caaagccaca 74940 ggtttgcagt gttacacaag ggccaaagga ggccatgagt tgtctttggt tgtggggccg 75000 gagggtaact gttcatgaaa atagtgagtg tctgaagatt aagaaaatca tgctgcagca 75060 gaggagaagg gagaggaagg caggaaggga aaggagatgc ctgagggtca aaagctgagc 75120 ccaagcctaa gcccaagctc aagttcaagc cccagcatgg cacaattttg tgaattaact 75180 caggctgagt tgcctccagt ctttggaatg tcatcttata ctggtactgc tgaggcagag 75240 ggcagtaatt ggttctttgg gataggagaa ggggcagttg ctgaaataca aaattaatag 75300 tcagcatccc aagttcctca attgcagcca aaatacatgt gttcaggcct ttcggcagta 75360 ccgcccccag aactaccagc tgtagtgtgg tctattccca gacagcaaca tgcaagaata 75420 agtttacaat acactcagcc cttgtggctt aagatcaggg gctcagaggc tgtgacaact 75480 catgatgctg aaaatgtatc caatgaaaac gaagtactag cttgtttagt agtaacgaag 75540 tactattaat ttttaatata gtctgatact ttattttcta attgtagaag caacattctt 75600 agctatatct ttctagaatg ttgaggcaaa agagtaaatt tatagtgatt ttcactgtta 75660 ccagattgct ggaataggga atttctggta gcaagatggg aatttttaag ttggaagggt 75720 ctaacacatc atatagccgt ctccatctca ttttttttgc tgaaaaaact gagcccttgc 75780 aaatgtcagt tgcaaatctg ggagtagtac tcatgtctct gaagttgtta tatagaattc 75840 tttttattta ttttaataac aatatttatg atagttgaaa ctttttgagt gcttactata 75900 ttttatttca tgcattatgt tcagcacttt acatgtttta tctcacttga tattcacaac 75960 tttatgagat tggcactgtt attgtagcca ttttatagat gaggaaactg aagcttagag 76020 agttaaataa agagctcaaa atctcacatc tagtaagtgg caaaaacagg atttcagctc 76080 aagcaatctg attccaaaac agactttttt cactgtgctg ccattctttt gcctggtttt 76140 tctgttaact tcttaaatat atgtcatgtt tcatgcttac ttcctcattt tcataaatat 76200 attacctgct cacttataca ttatattgct tagaaacaaa cccaaccctg ttttcttatg 76260 gactgtatcc tgaaaatcac tgtttttaat atgtggttaa acaagtgttt tattagtgca 76320 tttatataaa ttatttaacc aaaacactta accggtgaaa gtgctttact gtgtgagaat 76380 gtgcatgttc taagaacctc taatttttaa acctccctta ttctcagcct tatatttgtt 76440 aaaacctgtg tgttaacaca gatgcaccca tgttaggggt taattagaga aaccaacctc 76500 tttatagatt agcttgttca tctttaagtt gctaggcagg cactgtaaat tcagagaaca 76560 atctgattgt aagccacaaa tcaatgaaat taattttggg gttgcctttt aaaatagtgt 76620 cacaaaattt aaggataaag aatgcaaaaa tgatgccaat tatctcatca cattagtttt 76680 gatttaattt ttttaatttg aaaaaaccta ctcttaaact taattgattt ttttaaatat 76740 aagtttggag ataattttta attcagtaaa gttatagtga ttgaaaaagt agtttataat 76800 ttttaataaa ttgatcttgt tttaattttg agtcatattc tagaagtgct tctttgcaaa 76860 ttggtaaatt gcacatacat ttccacttat atacaagata attgctatgg ttggtttgta 76920 taatagatgc agtgcatctg aagagctatt ttatgagaat attgtttctt gtatctgtca 76980 cgagccaaaa agaatatttt taagaaagtt atattcttgg tgatagaaca gctgataatt 77040 tagaaacaac tgtaagacag tccacttttt ctgattatga aataatacca tagttaagtg 77100 taatttccta taatagaata aaaacacgag ttctagtttt aggggaggca tgttgttacc 77160 gtaccttaga atttctggaa gatgacatat tcatgctttt cctgataact gctgagtctc 77220 ctgctctgtc tgccaatcca gtcaagaagc ctttgctagc aatcaattaa taatacgttt 77280 catttataca tatttcctat atatagtatg ttattgatta tctcagtacc actgaagaga 77340 ggttatctgg gtcattggag ctttgcttct agatttgtga agccataaac ctatatattt 77400 aaaataggag gccaaaaaaa aacgaccatt gctttatata gttagatttt cagtgaattg 77460 agagtttatc atttgtaatt atacattaat caaatataag gcataatata cccccctgct 77520 tatatcagca ccatttcaaa tgtaatgtta aaaaataata aatggagaag tagatagcta 77580 acaagtaggc ttaatttaat aagacaaagt aaatggcatt tggaaacctc atggatttaa 77640 tgttttattt aaatgatttc tgatttttaa aaagtaaata ttgtttccag aaggctgaga 77700 aacaagttag tagggagatt ttttctttgc aaaaaaattt tacagttgtg tctttaacat 77760 tgtaccacaa actgttgtcc taccagtctc tttgtaagaa agctatagac atgttgggaa 77820 tgaatgagct ctttcctttt taaaatatca gttttacatc attcaggttc caatcgttgc 77880 acttactgct actgcaagtt cttcaatccg ggaagacatt gtacgttgct taaatctgag 77940 aaatcctcag atcacctgta ctggttttga tcgaccaaac ctgtatttag aagttaggcg 78000 aaaaacaggg aatatccttc aggatctgca gccatttctt gtcaaaacaa ggtaaggatt 78060 taatggttga tgaattttgg taatgatttc cttttttttt ttttaacaac ttatgtattt 78120 tatgttattt acgatttcct tctaatgcat atttaacata tttcaaattc cacctagttt 78180 tggttcaagt caagcatgat gttatataat caattcagtg attgagacta gtgtattttt 78240 aaaagcagaa accaattctc ctaatatttt aataccccat tctgttgctt aaacagggca 78300 tatactattt atttttattt tttaaaattt tacttattta tttatagaga cagggtctct 78360 ctgtcgtcca ggctggagtg cagtggtgtg atcacaactc actgcagcct caaactcctg 78420 ggttcaagca gtcctcctgc ctcagtctcc caagtagctg gaactacagt cttgcaccac 78480 catgcctggc taggacatat acttttaatg attgataagt aaacaagcaa acataaaatg 78540 actctttcat ctgaattctg tctagtttac taattacatg acttcagtct taaggagctt 78600 agaaaaggtc accttacaaa cacagtggag cctgtattgt gttccaagga ctattgtagg 78660 cgctttctat ataaaatgat ctaatttaat ccctataact gctcagtaag ttacgtatta 78720 ttttcatttt attgttgagg aaactggcat tagtactttt ttctgtttat tttgtttaaa 78780 ggcattttaa atatatatgt taagaagttt tcaaaagcct atattttact ttttataagc 78840 ctttatttta ctatttgaga cagtgtcttg ctctgtcacc caggctggag tgcagtggcg 78900 caatcccggc tcactacaac ttccacctcc tgggttcaag ctattctcct gcctcagtct 78960 cccaagtagc tgaaattaca ggtgtgcgcc accatgccag gctaattttt gtatttttta 79020 gtggagacgg ggtttcacca tggtggccag gctgatctcg aactcctgac ctcaagtgat 79080 ccacctgtgt tggccttcca aagtgctgga attacaggtg ttggccactg cgcctggcca 79140 gtttataatt ttaaacatta aaataaatgc ttcttgtcca atcatggtgt ctcacaccca 79200 gaatcccagc actttgggag gcagacgttg gagaatcact tgaggccagg agttcgagac 79260 cagcctgggc aacatggtga atccctgtct ctacaaaaaa tacaaaaatt agctgggcat 79320 ggtggtgcat gcctgtagtc ccagctattt gggaggctga ggtgggagga tcatttgagc 79380 ccaggatgtt ggggctgcag tgagctgaga tcacaccact gtactccagg ctggatgaca 79440 gagcaaggcc ccgtttcaaa aaaaaaaaaa aagcttctac caatacaaac acaaaacaag 79500 catagacaaa tagagtttaa agaacatcat tggtgttttc ctctaaaggg aatattgatg 79560 ctaggccaag aaaatcctgg agttattctt gaggacctta aggaataatt gaaatgtagg 79620 atttgctcct ggctttcttg tcctatattc agaataaaac aagaatggat cgaatatatt 79680 ctgagtgttc tggccattct agtgctctct gaagtgagta ctcactgtgt ttcacttccc 79740 tttcatccta aagaggaaaa gttcttttga agaaggctgt ttgtcctagg ttagagtctc 79800 cacagtcaga tcattatctc ctcctaatct ttgatcctgt tcagtctcta tggtactttc 79860 ccttataata acactctcta tggcactttc ccttataata acactctcct ttttaaagca 79920 gtttgccttt tttgtgtgta atattgttct cctggttttc tgacgtcctg gtcctcttat 79980 aatcctatgc aaatgtttct ttctgttttt catgttgact ctgctaattg aggtctttgt 80040 tactttttag ccgagactat tataatttcc ccaacagata cccctctccc cagtgcccct 80100 tgttgctttc tatgcagttt acaaattatt gtctgcaaac acatccttaa gtctggaata 80160 cctttctgga actccttact aggaaataaa gaccagactc agtgtaacat tcaacagtat 80220 tgaagatcta ggtatttaat atgaattttt ttttttaagg agatcaagaa agatttttgt 80280 acccattttt aatcctccaa gaagacttag gatagcagga aaccattgag agtcagaatg 80340 ctttctacag atcttaggtg aacagaaact ttcctcttca tgagcagtga ggtagagggt 80400 aattaaggct tcagagcatt gcccgttatt tccatcttct tcccttcctt taattctgct 80460 aaattccttt aatttgttta tcagtattca agtattttta tccattgagc taaggtgttt 80520 cttaaactaa ccctattttg ttaaagtctt aattataata tattcatagt acatttaagt 80580 gagatagatg agtctctcat ataatttagt ggttagatta gattagaatt ttctcccctc 80640 agaaaattaa gaggaaataa aagtctgtag caaatcactt ggcaaaataa tggctccttt 80700 tgtaatagga atttttactc ttttgattta tctgttacat aagttcaaat ttttacatat 80760 tttccacctt ttttaaaaaa gagtgatatg tagtcaatat caatttgagc aacactgttg 80820 catataaatt gaaaaggact ccaattttct aattccgtac ctcagttgtg atcactgttg 80880 gtattttggc atttatgtag acttcctttc tctgacccta ctactgtgca gatatatagt 80940 tgcagttttt tgttgttgtt aagttgatac agaaatagtt gcatactata tccattattt 81000 atgcaaattt tttttcattt aaagtatctg ctatctttcc atatattgca ttttcttaaa 81060 ttagagcctt aatatatagg atattacaat atctaggttt tgttgagtag ttttttcttc 81120 tttgaaaaca tgtttttaaa ataaggtttt tttttttttt tttttgacat ggagtcttgc 81180 tctgtcgccc aggctgtaat gcagtggcgg gatcttggct cgttgcagcc tctgcctcct 81240 gggttccagc gattctcctg cctcagcctc ctgggtagct gggattacag gtgcatgcca 81300 ccatgccctg ctaatttttg tatttttagt agagacgggg tttcaccttg ttggccaggc 81360 tggtctcgaa cttctgagct caggtaatcc gcccgccttg gcatcccaaa gtgctgggat 81420 tacaggcgtg agccactgtg ctggccttaa aataagattt ttatacacta aaagaaaact 81480 tacatttttc actccattaa gtagttcact gtgaattttt gatattgaag cccatttggt 81540 tgctgtcaaa aatagatttg aacagattat tcagtatgac tcttgtagtg aaattattgc 81600 cttgtttcct ctgcttaagt tttcagtggc ttttgccaca gtccttaaag gttttataat 81660 ttttttaatg tttaattttt aaatgtttgc ttaatatttc ttagtatgag tgtagataat 81720 gatgaacatt tagatgactt tttactatta taatgttgca gtgaatattt gtttacattt 81780 atcttttggc caataagcaa atatttttgt aaattagaat cctaaaattg aaattggatc 81840 aaaagttata tgcacttgaa attgattaac ttttcctaaa tctaaaatag tatagtcttt 81900 tttatattgt cagcataaat gaatgcactt atgtaaatga atatttttag gcgttaagta 81960 aaatattctg tggaaattga acatttaagt tgtttatact tctatggaaa tcgtttacgc 82020 ttttaataaa gaagcacaag tttctacaaa atacattcta acagatgttt tctataacat 82080 tcagtctcaa gattactagt aaatacttct ttgaactgta aaagcaatct ttcaatatta 82140 taagaaagct cttgctttag taaacattta gaaactcagc tttattatca taagcaagaa 82200 taagaacagt gtaacaagtt ttatgcacac tcctttgtaa accctcacca gactaattgt 82260 taatctggtg ccttgcattc cccaaagtat ttgtatctgt cgtttataag tttttatcaa 82320 ggtttcagct aaaacaaata aatttgtttc tggttttagc tttaatttga actgaaacag 82380 tcaaaactga gttttgggga cttcacacaa ttcatttgga tatttgattc tccataatgt 82440 tttaaatttt catgcactta aatatatcat tatttttgat aggctttctt cctttagtct 82500 tttctttaga aggtagaaag gaagaattaa ataagataaa accaaacggg tctgaagcat 82560 gtataaagta tatatgtttg ctcttttgtt cttctttttc tttagttccc actgggaatt 82620 tgaaggtcca acaatcatct actgtccttc tagaaaaatg acacaacaag ttacaggtga 82680 acttaggaaa ctgaatctat cctgtggaac ataccatgcg ggcatgagtt ttagcacaag 82740 gaaagacatt catcataggt ttgtaagaga tgaaattcag gtatgaggat caatcatcat 82800 tgctctccgt tgctcatagt ggaagtggat atttctcaaa tgtttattta ccagatcttt 82860 attgaatact ttctttgtgt tgaacataaa gcagtccctc tgataaatgt gggagaacaa 82920 acttgcagat tagtataaat agcaatctgt acctagtgct taggtgcaca gaggagggag 82980 gaatagctct gtcaaggtag ttgtgtaatg ggggtggtcc atccaggaaa attcaattag 83040 agtccaaaca tgtaagtaga agtttttcaa gtatgccagg ccagtaggtg atgaggggaa 83100 aggaattggt tatagaattc caggaagaag gactagcagg tgcaaagaca ctttgatatg 83160 agaacacata ctgggttcag gaaatgtgac tggtatggaa tggttggagg gaaagacaat 83220 gtggggtagg aatggcacaa agtatggaca aagaggcagg gtggaaccgt tagagacttg 83280 agagaacagt tgaatgggtc ggttggccag gttatagatg gctttaaaac ttgcaaagaa 83340 gcagtctggg cttggtatca tatacctgtt agttttcact gactacttta gccttagaat 83400 ttttagttta gatacaattt tctgtaatag gtaaaacgga ttaaagtaga ataactctgg 83460 ctgaagttaa tgtgagggaa aaggaggtac aagagtctcg tctctagacc ttgaagacac 83520 tccctgttgg ggtcttataa tccttggagt gccgcagaat catttgaaaa ccatcttgat 83580 gtactactct gtgtttttaa ataagataat aggattatag aaacattaga ctggcagcaa 83640 taagttggat tgatttgaag aagagaaact gaagaaggga aagggtatcg atgcagctat 83700 tgtgaaattc tacagttgag attcctgacc tgattggact ggctcagtgg gtgtcataga 83760 ggatttattt gggaggattt aagttcaagg cacatgagta ggtttaagtc aacaacttga 83820 cactgtcaac atgaaatcca cactgtaact ataagtccga ggaagagccc tctcctgaag 83880 ttaggaattt aacttcagct cttgcatttt ctgtcccacc ggtcatccat ttcttctcta 83940 tccatctcct tttctgatat ctagttgtta tcagtgttgt tgaaaagctt aagtatgatt 84000 catattcact gtctataaag ttcactacac atagtcatgc tgtaatgcat acccgcctga 84060 aagcatctgg tctctctttt ccttctttcc aaagataaga ataccattca cagctgttta 84120 gaatagaaat tttatccaaa ttcttcagtg tttatatttt tgttctgtta tttcagtgtc 84180 ttgaatattg tcaaatgaca tttattagct actactggta ctactgaatc ttaataatca 84240 atcttcaagc cattaactga ccaatggttt cttctatctt aatgtattag taattattca 84300 tttagagtaa aacatctccc agaacatgaa agaatacaaa ctttattcat gttacgttgt 84360 gacaggagac tttgttggat gcgcctgatt ttcctgccaa ttcacagctt cattaaaaca 84420 gtaatgcttt gaaatatggc ttaggaaact tcacaatgat cattaattac acctaatttc 84480 tggaagagta tatgcatgta tgtgttgcgg tattctccct tgctgtggca ggatgtcaca 84540 aatttttatc cacattacga aaatttaaaa attgatatgg ttttttctcc ctacgttgat 84600 atcagatatt ttgttttatc tgacagctgg cccaatgtac tcctactttg ccattataaa 84660 gaattcaaaa gcttcatatt tgcattgaaa gttctcaaac actttgtaaa gatgatgaaa 84720 gtatgtttca tcatctatgt agaatagtca ggtgttcttg caattgatta cttgctaccg 84780 agaattgaat acctactgag tgcataatgt atagaattct agatattcac ttttgtgtgt 84840 ttttacagtt gttatatacc ttagtgtggc tctaaaagtg gaggtgacag ctgtagctct 84900 taatgtctta cactgagtga tgtttagaat cttaaatttt cttttataat tttagaaaaa 84960 agtatacttt tctttcttat ttttataacc agatccaaac acatttgcat gtagataggc 85020 atttttagtc ttgaacattc atttttactt ttaatcctca cttttattag tttcgtatct 85080 ttttgtattt catttcccct ttcaagatgc cttgagtcct ttctttttag gaatgatgtt 85140 gtgaataaat tatttgataa aatgtcttta cacctgagag tttataagga tagtttgaaa 85200 atcatgtctg taaaataggt tgatctcacc taaaaataat accatataat taaaattaga 85260 attattattg tgttgcttat tgactcttac atatatcaaa aaattgctga gtcttattca 85320 gccagagctt ttacttagta tgatattcat tcctatattt acttttttct cacctttctc 85380 atactttctt ttacttactc agcattttcc tcctttcctc cctcctttct tttcttcttt 85440 ccttcttttc tcttcctttc gtattcctgg tccatcttag catgtaatct ttctttatga 85500 aatggcatgc agataggtct actgttctta cagtaaaaaa cttcaaggcc tcatgtcttt 85560 cccacttctg tttcccattc acaacctttt tagctgattc ttttggtact ttaccactat 85620 atcttgccat agtttatgta cctggctcct acttaatttt ttgtttattt gtgtattagt 85680 cgtaggcatt atttatcgac tcttctctct gaaagatgaa aggttagctc tctttcacat 85740 tcttaactgc ccttttttct taccttgtcc atgtatttct aacccccttt cctcctaata 85800 tgtttatgtc ataattttgg ctagattagt gtatacgatt tacataatta ttactctgta 85860 aatgcttttt atgatctctg agccatgtag tatattatgg ctatttttct ttcttatcta 85920 tttgtatttt tattgttatt acctaaaaaa aaattttcta tgtcttatca ctaattcttc 85980 cctaaaattt cccacaattg tgtaaactta cctcagtata ttcatagata tgagacattc 86040 tatcaatttt accctcttaa agatgcagag ataatgcatt atgtttcatc ccaccatctt 86100 taatgagaag cttccatctt agattaatat tagagaatgt taaaatactc tgcaatcagg 86160 taaggacgct tgaaacttca ttataatgca aaagttttct ttaacacaat aaatattttg 86220 aacccctttt gtgtcttgta ttcataggag ttcagataga ccactttatt tactattttt 86280 tatagagagt gaacagaaat cccatttcta gtcaccagtc cttaatctgt aaatcaggca 86340 gataatctgt aaatgattgg ttgaaatcac attgaattcc actttgtgcc agggacttaa 86400 gttaacgaac aaattattct tacaaaaagg tataaatgta aggttttcat tctgctaaat 86460 atgtttgtca aactgtgttg tgatttgttc tcagtgtgtc atagctacca tagcttttgg 86520 aatgggcatt aataaagctg acattcgcca agtcattcat tacggtgctc ctaaggacat 86580 ggaatcatat tatcaggaga ttggtagagc tggtcgtgat ggacttcaaa gttcttgtca 86640 cgtcctctgg gctcctgcag acattaactt aaataggtaa aaaaaattta ttgtttttac 86700 tcttgcagat ttctttcttt ctttccatat aaacctcaaa agtgtttgag gctatttcca 86760 gtatcccaag taatttgtga gtgcatttaa agtaaaaaaa aaaaaaaaga aaaataaaac 86820 ctccccaaat ccagaggaca tgtaagaaga acatttgtgg taagagttgc cacttggaga 86880 tgagctaatt tcagcatgcc ttagttagtg tgaggaatta actaaatcag gacaatactt 86940 gggcctgtca cagagatcct atggaatact ttcctaccat tgtgcattaa tgaacaggtt 87000 cttttcctct cctcagatcc tgtcaagttg cgatgtcttc agccatagtt acttcaacta 87060 ccactgattt tgttactgat tctttcttcc catgctacag tggtgattat tccagaggat 87120 ttctctcagt ccctatttga ctcttgttac tatttgtttt cttggttagt tccatgagac 87180 catgccagtt ctccttgact gtgtatgaat cattgtgttg cactgtactg acagactgcc 87240 gtaagtcaat attaagtgtt cagtatctaa gtgcaggaga acctttctac ttaagtactc 87300 aacaagtagt ttgttggcac ttaagttcta tgagattttt tgttgtaaag gaaaacatta 87360 tcttgcaaag attttggggc agcatttacc aatactttgt tccttcatcc gtaggaaaaa 87420 gaatctcagg agaaaaacct atacatggta accaatgggg ctgccaagct gatgaagtat 87480 tttcagagta cacctttgtg tagctgaata aattgagatc ttgaatggac atattagctc 87540 attttagtaa aatgataaga gagtgcctcc cactacagtt tttgttttta tgcatcatta 87600 aacaatgtgt ttttgattgt ccactgtgtt ccatgaacta tgctatgtgt gggagatata 87660 gtagtaaaga aaagcaaagt acctgcttcc atagaattca gtataatggg aatggtaatt 87720 ctttagagaa tcacataact atggatacat aggcttcatt ttactgttct ccttttgtgt 87780 ttgaaaatgt caacaatcaa aattttgtaa aaaaggaatc atgcaacata tttaaaatta 87840 taactgtgtt aagtgtaatg aagggaaatt gcactgagta gtaagaatat ataatggtgt 87900 gtggtatttc ccaagttaaa aaggtcagat aaggcttcct tgtggaagtg atagttcaaa 87960 tctgaaagaa gaataggaat taattaggta aaaatgtttg atgcaaattt taagattttc 88020 cttctgagta gtcagtagct tttccttctt aacatagaag atgacaaaac catccttttt 88080 ttgtacataa caattcttgt tttcctttag acagttgtat ctgtcaagct tcttatgatc 88140 taatttaaat aattgggata gaacacagct gtacatgtta ctattaaata tggaatatat 88200 caaacataag ttgattccta ccagttctga ttttatttgt gtattttgtt aaaggtactg 88260 aggacattaa tatccagttt tatattgtgc atttgaaggt tcatcaataa atacaattct 88320 tgtttctctg ggtcttaaaa gatattttaa atggttatct cattaagatt taacaggaaa 88380 taacagtgat tcaaatcaaa tagtggtgcc agaaacccat acttgaattt tgggtataga 88440 caggttaccc tttgcatcaa tcctgaggaa actaaaacta taggattaat caggataaaa 88500 aagaattgag caaggattca ggagggatct gtatcatcct ggtgacaacc ctcttctaga 88560 aaaaactaga aagtctaaga ataaatgaag ttgctggttc tcacctggaa aggtcagtta 88620 ctcacaaaat ttttagagtc tatcttatgc cataattcta tcactgagag aagaaacttg 88680 tccagtcatc atgtaatctt catgtaaatt tatgttttta attgcagaat tcataccaca 88740 ggcaaagtcc caatgtctgc atttgctgtt accttaaata gtcaaacccc aaagttattg 88800 taatcttttt ttaacagaga ataatttgca gagtaatctc ggtccggtag atctttcagt 88860 ggatccaaat gattgccatg aatggtttag aattttttta attttcaagt tgtttttatt 88920 ctgtggaata ctggacttat ttttgtagtc ccaaaagaaa aataaatatt tatttatttg 88980 ccgttaagag ttgtagtttt gttttctcaa atttgtcctg acactgacga gattagttaa 89040 atgtaggtca tctgaaccaa atacaaggaa ggaaggaccc agttctgaag agtgtgggca 89100 tttcttttct tgtttttttt tttttttttt tttttttcta taggagggga acgaggtgaa 89160 ctaaacaaac aaaataaagc aaaaaagaac tgatttttat cccttgaggt agaaagaatg 89220 agattacagt ggaccccctt gtctgcattt tcactttcta tgttttagtt actcacaacc 89280 acgtccaaaa tgttaaatag aaaattccag aaataaacaa tttataaatt ttaaatcagt 89340 ggtggctttg agtactgtaa tgaaattttg tgccatccca ctcagtctgc ctcgacttcc 89400 cttagaatca tccctttgtc cggtgcattc acgttgtatt tactccctgt ctgttagtca 89460 cttgttgcag tatcacagtg cttgtgttca agtaacgctt attttactta agaatgaccc 89520 caaagcacaa gagtactgtg cctaatttat aaattaaact ttttcatagg tatatacata 89580 taggaaaaaa cataatacat acaggatttg gttggtacta ttctgcggct tcaggcatcc 89640 actggacgtc ttggaatgta tcccttgtgg ataaggagga actgtatatg gttaacctag 89700 gagctagagt caacagttgg aagagacttt ggggataatt acatggaagg gcatggtggg 89760 tggtcgtttc agatgacaag aatgtttttg aataacggat catttgtgtc ttcagacttt 89820 ccagaactcc ttgagaatta tgcagaggta tttaatcagt cagaaggttg aatagtcaaa 89880 ttattagtga gtgaagtcta ttttgatgag gattttacta atgctgtccc ttagatatta 89940 taagtaaatc gttgttttct tttgaaatat ctgaaaccta gttaacatgg actttcattt 90000 gttcttgtaa agatatgcaa agctatttgg gagattgtca tcatctgata tttgatattc 90060 atgggctttc ttcacagaag actagaaatt aacagagtca tgatgaatta tggctgcatt 90120 gactttaaaa aacaaacacc tccttaatgt tatttaacaa ttttgaataa atttgatatg 90180 gcaaacaaat cagttataat cgattgagaa aggaacttaa ttctaatact tgactggtgt 90240 cccataataa cccataatac taagagacag ttttggaggg cgagaagtcc tgaagagctg 90300 atagagataa aggttcaaat ttgagcttct ttcagtgttc cttacgtcaa tgcttttagt 90360 ttctcataca aaataaaata aagaataacc tttttactgg gaaaaggtaa aaattaataa 90420 attgtagaag cattgtttga agccaaaaag tgtgtgacat gtaaattgaa atgaaaaacc 90480 ttagagtttt tgatactttt tcaaagcagc taaagaattg atacttggac acaggaagaa 90540 ttttttttca aaagcaattt ttataaaatc agaaaaatgt ttacctcttg ttgggggcat 90600 tgactggaaa ggaatacaac agaactttct gagatgctag aaatgttttt ttatcttgat 90660 ggggtgtggg ttttgtagat aatgaaaaat aaacagtaaa aaataagtaa aaaaaaaagt 90720 aagaaagttg ccaatacagt tttacatatt cctgtgatgt ttttaatcga caggcacctt 90780 cttactgaga tacgtaatga gaagtttcga ttatacaaat taaagatgat ggcaaagatg 90840 gaaaaatatc ttcattctag cagatgtagg agacagtatg tattatttat tttatgccaa 90900 tagtatggat ttatggatga tgctctttta agacaacaat ttggctaaat aattatcagt 90960 attttgaaaa aatattttgt tgctgttaca tgtgtgctga atttttaagg ctaacttctt 91020 tgtgtctgag taaactgaag tcaaataatg aagtcccaag tgaatcaatt aatggtgatt 91080 ttacctcatt attttcagga atgaacttaa catatacgtt tctgttcttt tatttaattt 91140 aaaattttgt cttgggtaga atcatcttgt ctcattttga ggacaaacaa gtacaaaaag 91200 cctccttggg aattatggga actgaaaaat gctgtgataa ttgcaggtcc aggtaaagat 91260 ttcttattat agatggacat tctaaaagtc tttctttctc ttccttttca tgtttaactg 91320 aatttttgtt gaatgataag tatttcagtt ttttaaacaa aacaatgaat gtgtttagat 91380 atgagaaagc aaacaatatt aaagtatttt gcttaaaaaa tagataaagc aataaaatgg 91440 tagccctaaa tctaaacata tcaatagtta tgttaaatgt aaatgatcta aaatattatt 91500 taaaggcgta aattgtaaga attggtttaa aaacatgacc ctgttctgta cgttgtccac 91560 aagaaatcca ctgtaattat atagataggt ttaaaaaaga atgaaacatt acattccatg 91620 aaaacattaa tcaaaaggaa gttggagtta ctttaatatc agacaatgga cactttggag 91680 caaagaatat tatcaggata aagaaggata ttatatgatg taaaagaatc atttcaccaa 91740 tgtatcagtc agggttcacc agagaaatag gacgattgat attatggaga tatatatata 91800 tatatatata tatatatata tggggaggga aaggaagaac aaatatgggg agagagggat 91860 gaggcgactg attttgaaga attagctcac gaaattgtgg gggttggcaa gtctgaaatt 91920 tgtagagcag gtcaataggc tggaaactca ggcaagaggt gatgttgcag tcttgaggca 91980 gaatttcttc tctagcaaac ctagtttttg ccctttagtc ctgccactga gtggatgagg 92040 cccacccaca ttattgacaa taatctcctt tacttaaagt caactgatta taaatgttaa 92100 tcacgtctac aaaatatttt acagcaacat ctagattagt gtttgaccaa acaactgagc 92160 atcataggct agccaagttg atgcataata ttaatcatca caaccaagaa gacatcatcc 92220 taaatatata tatatatata tatatatata tctacttaac aaaaagactg acagaactga 92280 aaggagaaat agagaaatct acagttacat ttggtgactt ccagcatctc tcaataatca 92340 ataaaactga cagaccaaaa aatcagtaag aagacagaag aaatgaacag gattatcagc 92400 atgctggatc tcattgacct ttttagaaca ttctacccaa caacagtaga gtacacattc 92460 aagtgcagat gcagtattca tgaacatgga tcatattcag agtcataaaa caaaccttaa 92520 caaatttaag aatcttgtat ttgtatattt tttgactaga atggaattaa actagaaaac 92580 aataacagaa agataacaga aaagtctcta aaccttagaa attaaataac acacttataa 92640 ataaatccat gagtcaaaga ggaagtctca aggcaaatca gaaaatgttt tgaactgaat 92700 gaaatgaaaa tacaaaatgt gtgagatgca gctaatgcaa tactgagaag gaaatttata 92760 gcattaaata cctatgtaat aaaagaagaa aggtctcaaa tcagtaccta agcttacatc 92820 ttaagcaaca agcaaataag agcaaaataa atcaaaatga agtaaacata aggaaataac 92880 aaagaacata agtcaatgaa tagaaaagct atggtcatac cactgctgtc cagcctgggt 92940 gacagagtga gaccctatgt caaaaaaatt taaaaacaaa gcagcatgca gcattcattg 93000 tcagtgaata gaaaatggga aaacaataga gaaaatcaac tcaaaagctc attctgtata 93060 aagatcaaca aaattgatat aaacttctaa caagactgac ggaaagagaa aagacacaga 93120 agaccaatac caggaatgaa agagggaatt tcactacaga cctcccaggt attactaggg 93180 atgataaggg aacactatga acaactcaga acataacttt aataatttag atgaaatgga 93240 tcaatttctt gataatctca agctaattaa acttacagtg aattagataa cctgcatagt 93300 gttacaacca ttagagggat tgaattctat gttaaaaatc tctgaaaata aaatccccta 93360 gcccaaagaa tttcaatgac aaattctacc aaacatttag aagacaaaat aataccaatt 93420 ctatagcatg attccattta tataatagtc tttgaaacat aaaactatac tagagggatg 93480 aagaaaagat cagtggttat tagagattgg gggagggaga aggtatgatt ccaaaggata 93540 gtacaaggca gtattttgga gtgatagatt tatcgtgccc tgattgtgat gggagttaga 93600 tgaatctatg gatatcttaa aatgtgtaga actttacaca tacatacaac caatttgcct 93660 atgttaattg aaaaaataaa ataaaaacaa attatttacc tggtgggtta gctacgtacc 93720 taagttcaat agctgcgtta ctgtaagaca aaagaagcat tattagggat ggagttgttc 93780 tctgtgtaat gacaaatact tcttcactaa gaagacagaa ttgttttatg cacctttaaa 93840 aaaaaacaaa aacaaaaaaa atacaaccaa caaacagtaa cttgctggtg cggtggctca 93900 cacttgtagt attagcactt tgggaggctg aggtgggagg atcacttgag accaggattt 93960 ttaagaccag tctgggcaaa aaaccgagac tgtgtctcta caaaaataaa aaataaataa 94020 aaaaaattag ctaggcatag cattatgtgc ctctagtccc agctactctg gaggctaagg 94080 tggaaagatc gcttgagcct ggaaggttga gactgcagtt gcagtgagcc atgatggcac 94140 cactacactc caggctgggc atcagagtaa gactctgtct cacataaaaa aaataataat 94200 aatgataaaa actagtctgg gcatggtggc tcacacctgt agtcccagtc ctttggaagg 94260 ccgaggcaag agaattgctt gaacccaaga ctttgagaac agcctgggca acatagcaag 94320 accccatctc tatttaaaaa aaaaaacaaa cttaaaaatc cagcaaatac ataaagcaca 94380 aagccgacag aagaggtgga gaaatcaaca aatccaccat caaagtggga gaatttgata 94440 taattttaag ttattggtag ggtaaacaat ccaaaaatta gtacactgta gaaaatttgg 94500 tcaacatagt aataagtttg cttattacta tttatcagta tacatagtat actgatttat 94560 cagatacata gtatatggag ccctagagca agcaactata gcagtgtatc tcaagtattt 94620 ttacttcatg acccacatag caaatgatat gtgtatataa cacactgggc taattgtcag 94680 agttcagttt ctgtccaaaa ccctaagatc tggagtgatt aacctttcag cactcttaga 94740 actcacttgt ttgtagcaca ctgattgaga agcactgaaa gacttcactc ctcaaacata 94800 catggaatat ttctaaaaac tatgtattgg gccgggtgca gtggctcatg cctgtaatcc 94860 cagcactttg ggaggccgag gcgggtggat cccgaggtca ggagatcgag accatcctgg 94920 ctaacatgat gaaacgccgt ctctactaaa aatacaaaaa attagccgga tgtggtggcg 94980 agtgcctgta gtcccagcta ctcgggaggc tgaggcagga gaatggtgtg aacccaggag 95040 gcggagcttg cagtgagccg agatcgcgcc actgcactcc agcctgggca acagagcgag 95100 actctgtctc aaaaaaaacc aaccaactga acaaacaaaa aaactaaaaa acaaaaacaa 95160 aaaaactatg tattagagca tgggttggca aactatggcc tgtaggccaa atctgcatgc 95220 tgttttattt ttttttattt ttttgacata gggtcactac aggctgtcac acaggctgga 95280 gagcagtggt atgatcatag ctcactgtaa cctcaaattc ctgggctcaa gcaattctct 95340 tgcctcacct cagcttccca agtagctaca ggcatgcact accagaccca gttaattaaa 95400 acaaattttt ttttggtaga gacagtctca gtatgttgcc caggctggtt ttcaaactcc 95460 ttgcctcaat cagtcctcct acttcagcct cctaaagtgc tgggattata ggcatgagcc 95520 atcacgcttg actaatgttt ttgtaaataa agttttctca gaacacagcc atgccttttg 95580 tttatgtgtt atgtagggct gcctgagtta agtagttggc tgcaaagcct atcatggcct 95640 ataaagcctg aaatacttac tatctggtcc tttatagaaa gtgttttctg accctgtact 95700 agactagctt gtctcaaaat tcttcaatga atttggaagt tttctcacca cattttctga 95760 ccataatgca cttgagttag aagtaaataa gcagataaac aacaaaatcc tcatgcattt 95820 ggaaattaaa aataacactt aaataattca tattcaaaga aaaaatcaaa ctggaaatta 95880 aaaaaaattt taaacctaca gataactaca ttaatatgca ttaacatttt tagaacttag 95940 ggatagttac aatgatatac attaaaactg gtaagaggct gggtgcgttg gctcacgcct 96000 gtaatcccag cactttggga ggccgaggct gggggatcac gaggtcaaga gattgaaacc 96060 atcctggcca acatggtgaa accccgtctc tactaaaaat acaaaaatca gctgggcgtg 96120 gtggcacgcg cctgtagtcc cagctacttg ggaggctgag gcaggagaat cgcttgaacc 96180 tgggaggcgg aggttgccgt gagccgagat tgggccactg cactccagcc tggcgacaga 96240 gcgacactct tgtctcaaaa aaaaaacaaa acaaaacaaa aaaaaaaact agtaagaggg 96300 cccagtggct cacacctgtc attctagctc tttgggagac tgaggagaga ggatcagttg 96360 aggccaggat tcaagaccag tctgggcaac ataacgagac cgcatctcta caaaatttta 96420 ataacaacaa caaaaaaaac tggtaagagg caacattgaa tagtactttg tgggagttta 96480 ttagcttgaa atactcataa tagaaaagaa aattaatcag ctaagcatct cactaaagag 96540 attaggagaa taaacctaag catagttttt ttcccccaaa cattattata tctggaatat 96600 tgaatgcatt cttattgcta tttcaaagat acttactcta aggaaagcaa ttgaattagg 96660 tagttgaact ctatagtaga ttttctttaa tgagtccttt tgttctcaac ctacttaaat 96720 aattctcatt tgaatttatg atagtttcag atctacccaa agggtgactt aggaatttaa 96780 cttctaaatc tatttaaatg aaaggtttat aatctttttg tcatatttta cagtcgttag 96840 cgtttaacaa tttatagcat aggatttggg tttttttttt tttttcattt taaagaagaa 96900 gtttatttaa gcaagacact tgactaaggg aagactatct tggagttatt attactagag 96960 taatttattt ctacttaaag acagattgcc ccacaagtaa cagctacata aaaacagttg 97020 taaaattgtc cttggtttta caatgataaa tgaaaaacat taaaattctc taattgaaca 97080 aggtatgcaa ggatttttat attgtttttt gctaaaacta tgacagcaaa ataacatcct 97140 ggagtataaa gataagagct gaatgagcag gccactaggg gacaaaggga gtcttttcac 97200 agaaccaatg cttcttttgc ccaccccatc tccatcgaag tcaatctaaa catattattg 97260 gccatttagt taaaaaaaga aagaaaagaa aagcaatatg cttgtggaca tacaccagtt 97320 actttatgtg cagtaaaaga gtaggaaggg gaaggtgaaa gaatagagaa aactatgtag 97380 tcaggatgtg gtggaaccaa attgcaactt tctttttttt tgagacagag ttttgctctt 97440 gtcacccagg ctggagtgta gtggtggccc aatcttggct cactgcaacc tccgcctctc 97500 agattcaagc cattctcctg cctcagcctt ctgagtagct gggattacag gtgcatgcca 97560 ccatgcctgg ctaatttttg tatttttagt agagatgggt tttcaccatg ttggccaggc 97620 tggtcttgaa tgcctgactt caagtgatcc acccgcctca gcctcccaaa gtgctgggat 97680 tacaggcgtg agccactgcg cctggccaaa ttgtagcttt ctaattgaga ctgtcttctt 97740 ggtctggaag agcagagttc tgcagtaaaa taacaggtcc cccttttagt agacatctcc 97800 atgtctgctg ctggaacaca tcagttttgt cttaagcctc acttccaaat gtgcagatgt 97860 gtctggttca ttgattggct gcctgtcaaa ttgaaacctg atctgcctca ttggcaaacc 97920 gtgcccctta caataggctt tcattggttt actaagcggt gtggtgcgtg gctgttcatc 97980 ttaaactgca ccacagttta agatgaacct tcaaatgaac attatccttg ttctcagtct 98040 tgactttcct tgggcttttt gtggaccctg gtgagtgtgg cagtctcctc agctgctgct 98100 tcacaaaaga ggtaccaggt ctgccccgaa tgagtgagcc cctaaacagg accaggagtg 98160 gcagaagaaa gaggcagcaa ctgagatgtg ttttttctaa gctgaaaggc tttttttttt 98220 tttttttttg caacacacct ttaacactaa agtccaatat ttatataatt ggtcaagtaa 98280 gtggagctgt tctagctata aatatggcaa ctctgcttgc tcgtcctatt attgacatta 98340 ttcctttctg tggtctgagg tgcctcccat gaaacttgct tctaggacac taggattgag 98400 aaccatcagc gtaacatatc tgttacgcta caatagttta ttttcatatt ttagctactt 98460 tacatactcg ggtataatga actttattca tagcttctga agcagttggc acatttgaga 98520 tattttttac ttggctaatt gttatgctaa atcttttgat ttctaaagat acatgccttt 98580 gctaagcttt cttcaaatgt tattattttt atttagattg gatcattgct attccatgga 98640 tgactcagag gatacatcct gggactttgg tccacaagca tttaagcttt tgtctgctgt 98700 ggacatctta ggcgaaaaat ttggaattgg gcttccaatt ttatttctcc gaggatctgt 98760 aagtatatat ctgtgaattc ccttcataga tcttctttta cttctattac acttttcttc 98820 agaggtttgc agtattatga ttgtagcttt gacttcagat gggtgactag gaactcatag 98880 agtcttacta agttccagtt aaacactaca ttcattactt tggataaaac ccgtgtgtat 98940 ggcatcttct gctgttttca tgttcaagcc gatgttcagc tctgcagctc agtctggaag 99000 cattgtgtta atttatcaca ttgcatttgg gtgaatccct agactagtct tgcttaggat 99060 aattaggaaa agttaacttt cattgtatca agggacaggt agaacaaaat tgtccttttg 99120 tccaggaaac cattaaattc ttcaaggaaa actttagtta tagggattat tttttaaatg 99180 tctaatttca gtaacaatat ttgggacata tttatttttc cttctgtttc ctatcagaag 99240 tatttaaagt tataagaaaa ttgtggtttt tgcctttact aatgaataaa taatcaatta 99300 aattcagtta cttttttttg gagtgattga tgttccagta ttcttctaaa caaccacggg 99360 tacaaatgtg aataagatag gaccgttgca gtccaagagc ttgttctgta gtcctttcct 99420 ttatatgatt ttttcccctg atttagaagt ctataaagca aagctaagta ttacacactg 99480 ataatggctg aataaatcaa gagcaagaga taggatactt tgcaaatatg catatttatt 99540 aaaaatgtac tttaaaatag agattaaaat tctcgtattg aatgtagaat aggtaagcat 99600 ttatttgtga aatactcgaa tgcttcatgt aaatactttc tgagtttgta tttttagaaa 99660 ggaacatttt ggaggctgag gcaggagaat ggcgtgaacg tgggaggcgg agcttgcagt 99720 gagctgagat tgtgccactg cactccagcc tgcgcgacag agcaagattc tgtctcaata 99780 aaaaaaaaaa aagaaacata tttattaaat tagttgtgaa atatttttaa tgaaatatat 99840 tgaaaacttc tgttgatttt tcatgtactg atgtttttag attctaaatg gagtttaaaa 99900 ttttgtttgt aaatcacaag ttggattaga aatttaatag tagaagtgtt gcctaaggac 99960 tattttaggt gctgtgagtg aaactgtatt ttttataaca agaattttag ttgtaaggga 100020 cagcttaaat ataattgaga tctgtgaaaa tgtattctgt ctctatcacc ttcagaacct 100080 gtgtatctca gttgaatgta taatttataa aaattattct tgttttaatt tggtgtaatc 100140 cagccatatc cagtatcaac aaataagtct aagtaggctc cttgacaaac ttgaactggc 100200 cacaagagag atcagatttc acctattaaa aaaccaaatc agaccactta cactgacagt 100260 ctcttctggg agtcctcaaa ttaagaagtc tatcctttgt gaaatattac actacccttg 100320 ctagataaaa cttttctaaa agtaccactt aatgaaaatc tgtagacact aaatgcaatg 100380 aaaataaggc attgtttttt tttctcccca tttcagtgat cttggtatcc tgggatattg 100440 tttttaaaat tatcgttata attcctttga gaatttagtg aaatgttccc tttaaccaac 100500 ttaggaaaaa ttaatatctt tgtacatgat tttgagctgt aaaataaaca ttttaaactg 100560 ggaataattg gagtttagtt aaagagataa tgtatataaa tatataacat agtagcagca 100620 tataattctg tcttacacaa gatttttctg aatagtataa acagttatgt agcctatcta 100680 ggagtttgtg aatagagttt aaaattttgt tttgaagctg caaatttgat tagaaattaa 100740 acagtgaagt tattacttaa ggaacttcgt tttagctgtc tgaacaactt actgtataaa 100800 aatctttaaa cattctgtat aaatatgtga taagatatgc aatgacctta attttataga 100860 ttagaaaata aaaacacact cattaattta cataactgac agattaagtg aaacttctct 100920 tctgatcacg ttagcagaat gccaaatctt gtcgtggcac tagaattaga cggtagtttt 100980 gataatacat gatttgacta tagacatttg ttgaaactat tggtagtttt aatcactctt 101040 gtaattttca aactatctaa cgggagagga ttatccatcc tgttttctag acaaactgtt 101100 tcatctgaat gaaatatatt cctagagata attatcacta cttcatcttt tggttttatt 101160 ttgcacatag aattatagtt cacaatgact ttctgaagct ctaaagttgc agctgtgagc 101220 ttctttggcc tgtagggact gggaaaaagc acccccgtcc tcccccaagc ccccccacca 101280 aaaaaagtta aagtgttttt aacaatagct gtgggctttt tgtagtttca gaacttagga 101340 gttgcccagg ctggaatgca gtggtgtgat catagcttga tgcagccttg aactcctggg 101400 ttcaagcaat cctcccacct cagcctccag agtagctggg accacaggtg ccaccccacc 101460 cagctatttt ttttattttt taattttttt gtaggtatgg ggtctcccca tgttgccctg 101520 cctgtctcaa actccagggc tctcaggtga tacccaccac ccttggcctc ccaaagcacc 101580 gagagtcact gtgccaggct gagtttaaaa tttcttgagt tggagtttat ggctattttt 101640 tccactagtt attaaacatg tatttttgta taaggcactg tattacattt tgtgggggga 101700 ttcaaagcta aattagatga gacgcatcat ctattatgga agatgttact taagaagaaa 101760 tgagtgtaat gtagcagaga attagataag ggacgtatga atacatataa atgctgttga 101820 agttctgaag agagagagtg tttagagaaa ttagaggagt ctttgtgaag gtatcactag 101880 aacttcctat ttttgtggaa tatatagtag attttggtgt gatactgtgg atttggacat 101940 tcactcagag aaggaatgag ggaagaatgg tggagaagaa tggcattcac agtacaaaaa 102000 gcaactgtga cttttaaaga agttaatatg gagaagtggc aagtcttttc ttctctcttc 102060 tcttctcttc tctcttcttt ttcttttttc tttttttctc tgtcagatac cgttgtaaag 102120 actttgcttt taccggaaac tgatacgttg ggtcatgtac cctggccagt cagttctctt 102180 tattctaaca cttagccgat cagttagatt tccacattcc atgatatgtc agttttggtg 102240 acccttattt ttccacctgg tttataaagg gaaagaatgt gatatgtcac ccaggctctg 102300 gagtacagtg gcatgatcat aggtcacagc agcctcaaag tttccagttc aagcgatcct 102360 acttccttgg cttcctgagt atgtggcact acaggtgcat gccaccatgc ccagctaact 102420 tttttgtaga gacagggtct ccctatgttt cccaggctgg tcttgaaccc ctgacctcaa 102480 gtgatccgcc caccttggct tcccaagata ttggcattac aggcatgagc cactgtgccg 102540 gcctgaaaat ttctcttttg agatggcatc ccacagaagt atacctgctt agagctaaca 102600 ctggtaaaaa gactatttaa ccctattgcc ttattttact gtagttgaga ttgagttaaa 102660 ctgaaagctg aatgacctgt cctaggtcat actgttactt tgtgccagag tcaggatgag 102720 caaatggatt tcctgcctgc tagtctagtg tcttttctat ttattgtgct gtaacataca 102780 gttttaaatt tgtattttta tgcccaatgg acatggtagc tcacacctgt aatttcagca 102840 cttttgggaa gccgaggtgg ggggattgct cgagaccagg agttcaagat gagcctgggc 102900 aacatagcga gactccgtct ctataaaaaa aaatttaaaa attagctgag tggtgatgtg 102960 tgtgcgtgta gtcctccttg tgggaggttg aggtgggagg atcgattgaa tctaggaatt 103020 caggactgca gtgagccatg attacaccac tgcactccag cctgggtgac agagcaatac 103080 cctgtctcga atgaatgaat gaatgaatga atgaatgaat gaatgcccaa atccgtaagc 103140 tatgttctgt atagcagctt tttcatcata ggcagttttt actcttatca gtggacaacc 103200 tacaaaatta actaaacact taaacaatta acagaggagg ccttgttcag agtgagaaat 103260 cattaagcat ttgttgttga aatttcttac tgtactctgt tttaattctg tttttttttt 103320 tttttaatgt tacttgtttt agtttggatt cctagttgaa aagggaatat gattccttta 103380 aaacaaagat actctgcttt aaagcaaagg tatatcatcc tcttcatggt gattgccatg 103440 gaaacaagac aatgtaaatt tattcaaata gtacacagtt tttatagtta ttgatcatga 103500 ggggaaggga cagttaatcc ctactgatca gataaaacct cattgtttca tactaataaa 103560 tggttttttt atgcttatga aaggaaaagc cagaagtgta atttttagtg tttagagagc 103620 tagtgattct agttagggaa cttaatacct ttgaagttat tagtttgcaa gcaatagaat 103680 ctactactac caaggtgacc cctagcagat gtagagtacc attaacaagt gttccaggga 103740 aggaaagcca actagatacc aagtcatgct ttttactctt agattaagaa attcaggttg 103800 agttaaagga tcagctgtta actaataaaa agcagattaa tattacagag ccaggctctg 103860 tcctggttat ggacttaatc ttcacagcat cctcaagaga taaaaatgaa tatacctgca 103920 tattagatga ggaaatagaa gataagtaac ttgccagagc tatgacgtga actcaggtaa 103980 tgtagcttaa gagcccccac atgtatgtat attgggtgtg tgtgtggagg gggtgcgtgt 104040 gagtgcttgt gcatgcgtgt ggtataataa gaaaaaatta gcatttatgc ctgtaatccc 104100 agcactttgg gagaccgagg cacgaggatc tctcaacccc aggagttcaa gaccagtcta 104160 ggcaacatag cgagacccta cctctacaaa aaaagtttta aaaatattag cgggcatggt 104220 ggaatacacc tgtagtctca gctgcttggg acgctgaggt gggaggatcc ttgagtccag 104280 gagattgagg ctacagtgag ctatgatgac acctctgcac tccagcttgg gtgacaaaga 104340 gagaccctgt ctccaaaaaa aaaaattaga actagttatc tggaggcctg tgttctagtc 104400 ctagctttag tacggctaca cagtgacaca ttaggctacc atttaacatc tttgaacctc 104460 tgataatttg ttaacaatat gggtaaaaat gactaagata aatcaaagag ctccagcatt 104520 ccctccagct ctgaaattct atgatgtttt atcttatttt acttacaaaa ataaattata 104580 ttatgtatat ttaaagtata caatttgatg ttatgggtta cctatagtaa aatgattact 104640 ataatgaaac taattaacat atccatcatc ttatattgtt aaccattttt ttgtttttgt 104700 ggcaaaagca gctgaaatcc actcatttag caggaatccc aaatacagtt cagttgtatt 104760 aattgtaatt ctcatgttgt acattcgatc tctagacttg tttatgctac atatgtttga 104820 cttttaaaca ttctactcaa atcaacccta agtcagggtt agcacagaca ggacttgtta 104880 acaaggtaga aggtgccaca ttgtacctgg gtgtttatat ttctctaaat cttgttctga 104940 tcatatttta ataaatataa tcatcaggac accaaaattc attccttagc tattaaaaaa 105000 ttctattcta ttttattgtt aagatttagg agagcatggt acagattctc ttaactatac 105060 ctatcagaag cctatgtttt aagtccaatg tataggcact gctctgtttg tctctggtgg 105120 gaacttaccc tgctttacct aatttcatcc tagcttcctt tttgtgaaag atcacccttg 105180 cttagcctat tttttggcaa atctacacct tggaaatagt agtaaatgac ataagcatat 105240 taatatttat gatgtgattt atttttgttt tcaagtcata tactggggaa gattctcaaa 105300 tattaaaaca atgtatcttt acatttatgt atgtcgttct tgttctgttt tagaaggctt 105360 gtatttgcat ttttaacatt ccaaaaggta aacctgtaat cataatgttt tcatcaattc 105420 aataaaacca ttacgtttgt aatagagagc cctatagttg ccttagttaa gtttgctgca 105480 actcatttta tatattcttt taattttgat ccctggattt ttaattgatt attaaacctt 105540 cattaggata tatatgaaat gtaaaaatat tgagttataa tctaccgttt tctaaaattt 105600 tatactgcat ttttatatag aaattcaaat tgctcataat cattctagtg aatttaagta 105660 gaaaggtatt tattactagg tattaaatgg cttataatat tgttgacaag gttccactgc 105720 aaaatagttc accaagggag ctgtggcctc ttctgtgatc aagaagccat ctgtcaactt 105780 gggaagcttc cactatagca cctaacccca gactacattg agtaggaagc tgtaataatc 105840 aggaagcttc tacctttgca tgctctgcaa accaacgtga acctgctgta atttgtaacc 105900 acaaaatgga tgcctgttga tacttacgaa gctcatcatt gtatgctggg ttctttgcta 105960 atactttctt ataaaaatta aatacctcca caatcatgca tgctagcaga aacagcagag 106020 gagtagcctt agcctcactt cctgcttata cctgtcatgc aaatatacag aacccagaac 106080 cctagctgaa agggagtttg agaactagta tttgtattgt cccagattct gcagtggaag 106140 aattcatagt ggatggaagt tagaatgacc cttgaattac aatcggccac attcatcaca 106200 aatacattaa ataagagtaa tttgccataa agctctatgt ttgtatactt ctttgttttt 106260 tttttttttt tttttttttt tttttgagac agggtctcac tctgttgctc agtctgtagt 106320 gcagtggtgt catcatagct cactgcagtc ttgatctcct gagctcaaac gattctcctg 106380 cctcagctcc tgcttcagcc tcctgagtag cggaacaaca ggtacacacc accacacttt 106440 gctaattttt tattttttat tttttgtaga gatgtgggtc tcactgtgtt gcccaggatg 106500 gtctcgaact cctgggctta agtgatcctc ccaaagtgtt gggattacag gcatgaacca 106560 ctgtgcctgg cccatatact acatatattt aaaagtagta tttaaatgtg taggatgaat 106620 gaaagaggca gtaagagaac aaagtgaatg aaaaagtatt tctatatgaa gtgaaagcag 106680 gagagtcctc tctgttagag aacaacagaa ttgcatatga cagactagct ttcttaatat 106740 ttctagaact tgatggctgt gaagagcgtc ccgtaggaat tctcccttca cttaggaaaa 106800 catacctcaa aaccatcagc tgtttagcat gcacctgctt ttcctggtat atctcagtga 106860 agcagctaaa ttgtaaatga ttaagtaaac tttgcagtgt atcatgtgca aaagcacagt 106920 aaaaacaaaa atgcattgga agctgtgagt tgttgcactg cactcatgga tgaatagctg 106980 ttggttcgca ttgcgttttt ttgttttgtt ttgttttgtt tttttgagat ggagtcttgc 107040 tctgttgccc aggctggagt gcagtggcgt gatctcggct cactgcaagc tctgcctccc 107100 agattcacgc catcctcctg cctcagcctc ccgagcagct gggaccacag gtgcccgcca 107160 caacacctgg ctaatttttt gtatttttag tagagacggg gtttcaccat gttagccatg 107220 atggtctcaa tctcctgacc tcgtgatctg cctgccttgg cctcccaaag tgctaggatt 107280 acaggcatgc cgcattgcgt tttatataat tctcatggtt ctagtctcga gctgtaggat 107340 tttgatcact gtttcaaaca ataatgtgag tttgctaaga ggtctaaata acaaaagcta 107400 agtgttccaa acacatatcc aaacctatac actgggcaat gcatctgaat tatatgtgaa 107460 atttcctgcc attatttaag acacaaaagg aacattattt tgataatgta tttatttgtg 107520 agtggagtgt tcagaatgag cacgatgggt ataacatttt tgtaggtttt taaagttgaa 107580 atttagtgta aatccaaaga atcaatagac aagtctgtgt tttacttaac ctatatgttt 107640 aaattagcat ttttagatac tgattttatt cctaatttca gaattctcag cgtcttgccg 107700 atcaatatcg caggcacagt ttatttggca ctggcaagga tcaaacagag agttggtgga 107760 aggctttttc ccgtcagctg atcactgagg gattcttggt agaagtttct cggtataaca 107820 aatttatgaa gatttgcgcc cttacgaaaa aggtaaacgg tgtaggagtc tgcctgtttg 107880 acttaatttt gtttcccact ccacattaaa agatcctttt tgcttttaat acggtagaaa 107940 ttggcttcat aaagctaata cagaatctca gagcctcatc cttcaagcta atgaagaatt 108000 gtgtccaaag aagttgcttc tgcctaggtt catttttcag tttttttctt gtaacttctg 108060 cattttttgt tgctatttat gtgattcaaa ttataccagt ttataggcct ctcacaagta 108120 aaatgaatta cctgtttgtt tttgtatgcc tattttagtc agtttggggg aagggatctg 108180 tgaggaaagg ataagtcata gagcactttt cttttttaag agacagagtc tctctgtgtt 108240 gctcaagctg gagtgcagtg gtgcgatcat agcttactgc agcctcgatc tcgtgggccc 108300 aagtaatcct cagccacctg agtagatggg actacagaca tgcactacta tgcccagcta 108360 atatatttta attttttgta tagagacagg gtcttctagt gcttcctagg ctggtcttga 108420 actcctgagc tcaagtgatc ctcctgcctc agcctcccaa actactggga ttacaggcat 108480 gatccaccgc tcccagccag aacattttct tggttgatgg gaagtagctg accatggtat 108540 ttagaaaact tctttctcat cgattaaaga agcagtactg aaatcaatgc ggaggaatcc 108600 atatatcata tttacttctg gtgtgtagaa gtggaaaggg aatacatttg ttgcttactt 108660 ttttgtacct ttacatgtga ttgatcactt gtgagttttt tctttcaaac atcttaaagc 108720 ttccagagct ttttctagaa aaaaaaatca gttttaagaa tcaccagttc taaaagggta 108780 atatcttatt catctttctg agaatggagt atcatgattc atgaattaga tacttgcatc 108840 ttaacatttg aaataattta attttattat tttttagttc gaaaactgta tcttcgggca 108900 ccaaagagca ttgttataat caagtaccag ttgaattaag tacagagaag aaggtttgtt 108960 ttaaagaaat tgttctgatt tatttcattc tttattgatt caaattctgt ttaaaatttt 109020 atattttaat tcctttccaa ttaaagagaa aatggcatat ataacaaagc ataaaattcg 109080 gccagggaag tgatgtgaac agactaaaat ttattgtata taatttctgg ggctaataaa 109140 gaattggagg tatttgagaa aggaattaat ttgggttctt ttaaacctat ctgctaactc 109200 atttggctta gagtagtcac atgttataat acttatagtt gatcaaaaaa ttgattccta 109260 agtgttctta ttaaagacac acacacacac acacacacac acacacattc tctctctctc 109320 tctctcacac acacacacat gcacacacac ttatgtactt tcttgctttt tttgacctaa 109380 gatcttagat aactattaca gattaaatac taatccactg gcagacttca gctaattaga 109440 acactggaat aataggcaag catagtgaat tacattttct ggtgaacttt ttctgcttta 109500 ttgaagtatg cagaatgtaa atgaattgtt tttataactt tggcacttgc tgtatcttag 109560 aacattcttt tgatgattta ttttctgtag ttttgggaga gataagacat tggaatgcgt 109620 ttctaactac ctttagaact ttagaaactg ataatttagg aggttatttt caggtgatta 109680 atttgacagc ttgattaggc aaagaaaaaa ttgtgatttt gagatttttg tttcttattt 109740 tcttcacatt taaaagtttt ttgaaacttt ttttaatgga cctttatatg tttaaatgca 109800 gtctaacttg gagaagttat attcttataa accatgtgat aagatttctt ctgggagtaa 109860 catttctaaa aaaaggtaca gagttccata tttctatgtt ctatacttgc tttatgagta 109920 cttttttttc taaagagaaa gaactgtcag atgttgggct atttcattgg caaaaggaag 109980 ttaaatttaa aacataagct tttcagtatt agaatgatca aagtgagcta taaaagaata 110040 atgttaattt aatagctaac acttcttgga tattactgtt tgtcaggcat tatgttaaat 110100 gctaagaact ttatatgtga tatctcattt aattcttaca agagtctaac agctgttact 110160 atttatcgcc attttatagt tgaagatacc aagggttaag aagttgacaa acttgttcaa 110220 gagcatacag ctaatggccg agctggcttt caagtctata tttgtctacc tctagcatca 110280 agacactatt tatttttctt tgtatgaaat atatacaggc atactttgtt ttattgtgcc 110340 tggctttatt gtgacttgca gatattgcat ttcttataaa ttgaaggttt gtggcaaccc 110400 tgcgtcaaac aggtcatatt agccccattt tccaatagca tgttctgttg tcatgtcttt 110460 gtgttatatt ttggtagttc ttgactggcc attcaccatt tctctccctc tcctcgggtc 110520 tccctgttcc ctgagataca acaaaattga aattaggcca attaataact ctataatagt 110580 ctctaagtgt gttttttttt ttttcgagac tgagtctcac tctgttgttc aggctggagt 110640 gcagtagcac aatctcggct cactgcaatc ttcgcctccc gggttcaagc gattctcctg 110700 tcttagcctc ctgagtagct gggactacag gcgccccccg atcatgtctg gctaattttt 110760 gtatttttag tagagatggg tttttgccgt gttggtcagg tggatcttga actcctgaac 110820 tcaggtgatc cgcctgcctt ggcctcccaa agtgctggga ttacaggtgt gagccgctgt 110880 gcctggccca tctctaagtg tttaagagaa aggaagattc acatgtctct caatttaaat 110940 caaaagctaa aagtgattag gcttagtgag gaagccatgt cgaaagctga gataggccaa 111000 aagctaggcc ccttgcacca aacagttagt ttgcaaaggc aaaagttcct gaaggaaatt 111060 aaaaatgcta ccccagtgaa taaaacaatg ataagaaagc aaagcaggct ttttgctgat 111120 atggagaaag ttttagtggt ctttatagga gattaaacca gccacaacat tcccttgagc 111180 caaagcctaa tccagagcaa agccctaact ctcttcaatt ctctgaaagc tgagagaggt 111240 gaggaagctg cagaataaaa gtttgaggcc agcagaggtt ggttcatgag gtttaaggaa 111300 agaagccatc tccataacat aaaagtgcaa agtgaaacag caagtgctgg tatagaagct 111360 gtagcaagtt atccagaaga tctagctaag atcatcgatg aaggtgcctg cactaacaga 111420 ctttgaatgt agaccaaatg ctttctacca gaagaagaag ctgtctagta ctttcatagc 111480 tagagagaag tcaatgcctg gcttcaaagc ttcaaaggac aagctgactc tcttgttaga 111540 agctgatgca gctggtgact ttaagttgaa gccagtgctc aattagcatt ctgaaaatcc 111600 tagggccctt aagaattatg ctatatctac tctgcctttg ctacatacat gtaacaacaa 111660 agtcttgatg atacctgttt acagcatggt ttcctgaata ctttaagccc attgttgaaa 111720 cctgcttaga caaaagattc ctttcaaaat gttattgctc attgacaaca cttagtcacc 111780 aagagccgta atggagacat acaaggagac taacgttgtt ttcatgcctg ctcgcttaac 111840 atccattctg tagctcatgg atcaagaagt aaattaacct tttaagtatt attatttaag 111900 aaatacagtt tgtaatgctt tagcttctgt agatagtgat tatcagagat gggtttttaa 111960 gaggttttcc agaaaacctt ctggaaaata ttcactattc tagaagtcat gaagaatatt 112020 tgtgattcag gagagtaggt cagaatatca atattaatag gaatttggaa gaagtcgatt 112080 cttattaaaa tcaagagttt agtgatagac atactgagtt tgggatacct gtggagtagt 112140 ccagaagtta atttaaatat atgggcttag tgtacagaag tgagcagggt gcttatatat 112200 gaataaatat tattttaaga tatatttaaa ttttccttaa aataatacct atacttgata 112260 taaaaagtta attggaaatt agtggcttat gacaagcata ccagcccaca ctcttcccaa 112320 acccactttg ctcttattca tagaagctgt catcttcaaa tcttccagct gatttccctg 112380 gcgtgtgcct tcttatttct gaatgacacg cttagagtac tatttttttg acttagcaat 112440 tttagaaatt ttctactcat ctcctattat ggtagatttc ccctccttca ttcctcctcc 112500 aatataatta tatttcgtca tattaataat ttgtttatat atatttttaa tataatatga 112560 taatattgta tttatattat taaaactaca caaatattat atacacacta ctaacccaac 112620 cgtgttatta tggccaccac tacctttatt tttttccttg tgttagtgat tgtctttgtt 112680 ttattttctt ggttttgagt attcctttta ctaattttct tttttcctat ttcaatctct 112740 cattatttgt ttactcattt ggagtgttcc ttgactttta tcccctctta cctagtgaca 112800 ttttaatttt agttatcaaa tttttaattt ctaagaatgc ttcttgttct cttcttgttt 112860 cttcttcccc accagccaaa aatctatgat gttatagcaa ggatcataca ttgtttccca 112920 gtaggttaag aaaccttggt taaaacctgt tgtatcccag taagttaaaa gacgttaacg 112980 tgtcatcttc agtatggatg aaagaatatt ttctttcaaa agcagttggt tgaggaagag 113040 aatgggacaa atgctctttt taaaacacca attttgtgat gaactcaaat tgcaatttta 113100 actttaccat tataatgaat gtatttgatc caaaatgttt aaaatctagg ctgttgtcat 113160 ttaaataaca aattacctta ctggtatcat gaagaataaa tgtttgtact gatttggaaa 113220 gacattctca tttaggggat gaaatagaaa gtcaatgagg agaaagaaaa gcttttatta 113280 tttattttct tttaaatatt ttagtatcat ggtacagtca ccagaaaaag cttacagttc 113340 ctcacagcct gttatttcgg cacaagagca ggagactcag gtaaggcttt tgtaaaaagg 113400 taattagttt atgataggat agttatgatt ctatgtatgc ttaaaattct gtattttgcc 113460 agcattttaa aaattgttct taagctaaga gtctgagttt atatttcagt ttatattcat 113520 tctaaggaaa aatgtggtat ctgaagctct aaaaataaag gactagatct tttaagtaca 113580 ctttaaaaag tgttgtttct ttgttttttg ttcagattgt gttatatggc aaattggtag 113640 aagctaggca gaaacatgcc aataaaatgg atgttccccc agctattctg gcaacaaaca 113700 agatactggt ggatatggcc aaaatgaggt aaactatctt ttgcatgtgt tctatttatt 113760 tccttctaac aaaatagatt tggaaaatat atctaagttg ataatatgac catagcttcc 113820 actgtcacat ctgggaggtg actcagattc cccctgctgc gatgcttatc tctttgccaa 113880 gctttagtac cgtgtttctg tatgaataaa aaccagttac gttttcagca atcatattca 113940 atatttataa aatctaactc attatttacc caccctgcat tttatccaaa tgccgaaact 114000 cctctttttg gattctttat ttttgattat cttaccatca catttgtagt cagaggttcc 114060 taatgcttaa aacctctgat ctgaattttc tctcctccaa tataaaaccc cttcgtcttc 114120 ctcttcttct tcttcatttt tttttttttt tttgtctgaa gacttgtctc actgtgttgc 114180 ccaggctgga gtgtagtggt gcgatcactg ctcactgcag ccttgacccc ctggactcaa 114240 gctatcctcg cacctcagcc tcccgagtag ctgggactac agaacatgcc accatgctca 114300 gctaattttt gtattttttg tagagacagg gttttgccat attgcctagg ctggtcttga 114360 actcctaagc tcaagcaatc ttcccgcctc agtctccaaa gttctggcac tacaggtgtg 114420 agccactgtg cctggcctct ttttctcatt taaatacttt tcataccttt tgtaaaacgg 114480 gttccttgtt gcctgtctat gccttcctcc tccttcttaa tgacaccacg ttaattctga 114540 ctgttttccc ttggcctgtt gcagaagcct cttaactatt aacccttcat tctctctctc 114600 tgtttcatct gatatatgag taccaaacta aatcttcctt tatcatatct tacttctgct 114660 taaatgtttt ttttctagct tagaattcaa ggccctctat ttatgaactt aaacttactt 114720 ttccctctaa gttacagaat ttgaaatggt ttatcttacc tggattgttt atcacttgtt 114780 gaagatccat tttcaacttc catatattta tttacagtgt tgcttctcct tgtagtttcc 114840 ttgattcctc aaaactcctt ttaagaattc ttgaagatct cgctttatta ctatttctcg 114900 ctttattact gtaaagacta tgagaaggtc tttcatgatc ttatcagcaa agtaattcct 114960 ctctcttgaa ttcatagagg actttcagat gaattctaaa gatgcttctg tagcacttac 115020 cacacaatgc tatattttat ttttttgtaa ttagtggtaa acaagtatta ttatatcttc 115080 tagattttaa actccaaata aagatactag ctccttacct ttttgtgtgt ctcctgtagc 115140 acctagcaca atgcctcata aacaggaggt gatcattaaa tatttagaag aaattatttc 115200 ccaagaatag ttgcttggta attgtatttg tcttttactt ccttttaaaa aattgtttct 115260 gtcactaaat tgcatccaat agatgttact tgagtgcaga attttctaat gacattacac 115320 agtgctacat ctgacactaa ttcttttgtt aaaaaataaa tattctggcc gggcgctgtg 115380 gctcacgctt gtaaatccca ggactttggg aggccgaggc gggcggatca cgaggttagg 115440 agatcgaggc catcctggct aacacggtga aaccccgttt ctactaaaaa tacaaaaaat 115500 tagccgggcg tggtggcggg tgcctgtagt cccagttact ctggcggctg aggcaggaga 115560 atggcgtgaa cccgggaggc ggagcttgca gtgagcggag atcgcgccac tgcactccag 115620 cctgggtgac agagcgagac tccgtctaaa aaaaaaataa aaaataaaaa taaataaata 115680 ttctaagacc atactttaat agaggtgttt tttttttttt tttttttttt tttttttttt 115740 tttggtgata gagtctcact ctgtcaccta ggctagagtg cagtggcgcg atctcggctc 115800 actgcaacct ccgcctcctg ggttcaagca attctcctgc ctcagcctcc ggaatagctg 115860 ggactacagg tgcgcgctgc cacccccggc taattttttg tattttagta gagatgaggt 115920 ttcactgtgt tgtccaggct ggtgttgaac tcctgagctc aggcaatcca cccgccccgg 115980 cctcccaaat tgttgggatt acaggcgtga gccacagtgc ctggcccaga ggagatattt 116040 aatgaaaaat aataatcatt agataggcag atttttagaa ggagggcatc gaatgggttc 116100 ttggatattg gacacaataa gaaatattga gctaaaagtc tgaaggaatt ggcagatata 116160 ctgttacagg taaacacttt gtagaagaaa ataatgaatg agactttctt ttgagatttt 116220 cttagcctct tagttgttcc cagttaaagc ctcatatttt tccttttcat gacaataaaa 116280 ataataataa aatcagtaat aaagtgaata tatgagatgt taacctgttc ctttatgaca 116340 atgtcctgtt taccaattaa cagtgtgttt ttgtggtgat gggggcaaga caaatcttta 116400 aatggtggaa agcaaagaaa gaaattataa aacatgatta gttgtattat acgttgtttt 116460 tggttgttgg aaaaactata catttattga gagaatcatt aggaagctga acatcagcta 116520 tattgctgga gtgatactgt ttcagtggtt tcttgacctt tttgttgttg ttgttgttgt 116580 tgttaaacac agaccaacta cggttgaaaa cgtaaaaagg attgatggtg tttctgaagg 116640 caaagctgcc atgttggccc ctctgttgga agtcatcaaa catttctgcc aaacaaatag 116700 tgttcaggta aaatactgtg gtttgcagga gctcttagag aataagcatt ttttgtaacc 116760 atttcaaaag taccctccag aagcaacatt tgctcacttt atttgcattt ccatactgga 116820 cacttagaaa atgaattaaa attgttttta cagtcaatct gttgtaaaaa catgtcagtt 116880 atctactttt aaagatgata ctaaaaagta gttgtccagg ctgctgatgt ctttctattt 116940 cattgggagg ttttgttttt aaattggaaa cattatttta ggttgataaa ttataatttt 117000 acattcaaat gtggtagttg gaatttaaag ctggaaagtt atccttgcta tgagttggtc 117060 aggagctcag ccactttctt ttggtttagc atcttctcta atctccctcc ccttccagta 117120 atgctgtctt ttgatagtaa gtggatttca tattattctc ttcagtttta atagtgtttc 117180 cttcatatcc ttttattatt gcttgttctg ccctaagtga ccatttccag aaatgtcatt 117240 taggattttc tctaaactcc acgtagcaga ctctataatg catactctgc agaaggtgag 117300 gcagtgggag gtagagggga gactactaga ctaggagtca cggaatcagg actttagttc 117360 ttccttacag ttgttcacct ggtgaacctg cacatgtcct ttaatttcct tgggtctcca 117420 tttcctcagc tatacaatgg aaatgacact tcctccccca catccaggaa acaacagatg 117480 acattagaaa atagaagaca tgggataagt ataaaatgtt gaaagagtta aacacattca 117540 aggcaatatt aagggattat tttttacttc caagaagctc ctggaagctt tgggcaggca 117600 cagttggatc ctactttaga aaaatctttc tctaactata agtagaaaac ccttctgctt 117660 tttgaatgta gcatttccct cttttgatat agagtatctt tggcaacttt gaattttctt 117720 tttcatactc ttatataaga catcatgtga aaattcttat ttcttactga gtttttggaa 117780 atgaaattat aatgtcttaa tagtttgaga aagaatatca tacctaccag cggtaattga 117840 gtaagttccc tctctttgga cacttgaaag tagtatcttc tttcatgaat tagtgatatt 117900 atttaataat gaatgagtga tctctcctaa ctccccttca gaagaggaaa atgaagtagg 117960 ggaaaaggta aattccccaa gggataggta tgaaaccttt atgaaccttc tggatagaga 118020 agatgactgc tgatttctgt gattagaaat tatacttggg ttattctgca aattgaaatg 118080 aattatttaa aaaaaaacaa ctttaatgtt tattaagcaa gttttgttat tcatgagttt 118140 cattagcctt ttattttttt tttaaatttt gaagtaaaat ttcttgctgt cacaatacac 118200 attaaaaatt acaaatatga cacatattaa acacattaag atggccgaat aggaaaaata 118260 tgctaaaata tttttatata aatacatttt ttgagaattt tgagaatttc tggaacaaag 118320 taatgatata atccataaat gtacaattaa agagtttaag gatatccaaa atacttggca 118380 aagtaatctg aaataatact cttaggaagg tagggcaaga atgtgattct agtaagcaaa 118440 aatgtgatca aatcgtattc tagtcccagc tactcgggag gctgaggcag gagaatggcg 118500 tgaacctggg aggcggagct tggagtaagc cgagatcgtg ccactgcact ccagcctggg 118560 cgacagagcg agactccatc tcaaaaaaaa aaaaagacta tatgaacatg tatggcataa 118620 atatgtacaa atattattta ttttaaaaaa attcaggggt agggacaggg tagttagaaa 118680 atatctaagg atgttcatga aataatactg gctatgaatg acagttgatg aaaccgggtg 118740 gtgcccatct tattccctcg actcgtgtat atgtttgata tatcccacaa taaaccttaa 118800 aaaaaaaaag atgagtggtc aattatagga agatataaat agaaaaggca ataaggacaa 118860 aagttggcaa agcttaccta agcactcttc agataaaaag acatttttgc taactagatt 118920 tgaatattat agtttaattg tcaaggaaaa tgcctcaact taatctttgt taagagacta 118980 cttaaggcac tatcagaagt tccctcatgg caaggtgcaa tccctcatgc ctgtaatccc 119040 agcactttgg gaggccaagg caggcaggtt acctgaggcc aggagttaga aaacaacctg 119100 ggaaacatag tgagacccga cctctacaaa aacaatttct taaaattagc caggcatggt 119160 ggtgctagcc tgtaatccca gctatttagg atgcttaggc aggaggattg cttgagcccg 119220 gggatttgag gctgcagtga gccatcattg tgccacaata ctccagcctg agtgatagaa 119280 aaaaaaaaaa aaagtgtctt tgttatattc caaacttgtt ctcaactttc aggtgagctg 119340 gcttcctgta taactcttgt ataggacaga acatactggt tggggcaagt gaaactgtct 119400 agttgtatgc ctcataaatt aatgaatttc ctttctaata tatacactga tatttataca 119460 cacatacaca taaaaccaag ctcaatagat gggtagtgca gctctattcc ccaaaaccca 119520 actaccctgt aacaagacac attagacttt tgagattgca aggatgagga ctgaaatgct 119580 ggcctagacc atggtgttgc catagtgggg tgaccagtct gaatagccaa caatgcttcc 119640 tcagtaaata cccattttgt cttggtggga tttctataaa ttgcaaaatg cagctattat 119700 gaagctgtaa aagagaaaca gaaacatgta acacctggga ctgttttatt aggcccaccg 119760 tatgctcaga acatgaaatc tccactgcta gggttatttg attgaaatta tcttttgtgt 119820 tgatgtgaga gtttagctct gagattcttc cacatgtaaa atgtaatccc ccaaagtatt 119880 tggcaagcac attttattgc cttgggtcag ataattgaaa cattaggcat catatatata 119940 gcatgtaaaa agtaaaacag aaacatttat gtttctcacc aagcagtaaa ttagtactca 120000 actaataaat ttcttaaact ccctaataac agaatatgga aacaaaaaat aaatctttcc 120060 aaaagaagag ctcatggaca catttcctca tatatgtata cataatatag tagaacacat 120120 gataaataac ctataaaaat gataccaata tcattcatca agagacgagg ctcttcttta 120180 aattattaat ttcatctgtt acaggtttta ttatgactgt agtatgctgt tttcatctac 120240 cttttatgtg tagttaaaaa aatagttttc tatctcttta cctttatttc agcctttaaa 120300 aagattccat tattttttca ttaatcttgt ttttcagttt ttcccatttt ttcttttaaa 120360 catttcttaa ggaaccatat ttaagatttt atagaatact tagatttcta gttgggatgt 120420 atcatttaaa attagatatg tagagagagt gttatgatat atttccttac gatatattag 120480 tggttatagt acctaaattt gaatagtgat tctgttcatt cattcattca ttcattcaat 120540 attcacttcc aggagattgg ggacttattt aaagacagag tagttcacat tatagttcct 120600 ttttttagtc cttcttattc gttaaagaaa agactaggaa atgtttgtta ttacaaatat 120660 tttattaaaa ttttgtgtgc tctagcatta ttttaccttt taaaatcaat atgttaaaaa 120720 tccaacttct ttttgagctc cccataaaaa gggaattatt tgttgcttat gggtttaact 120780 tgtgttattt ttttcttaat ggctaattat catacatata ttctattatt gtattgatat 120840 tactgatcat ttgtgctaca ttaaaaattc tgtagacaga cctcttttca agtacaaaac 120900 ctcaagaaga acagaagacg agtctggtag caaaaaataa aatatgcaca ctttcacagt 120960 ctatggccat cacatactct ttattccaag aaaagaagat gcctttggta agtgtgactt 121020 tcatgttaca gggaattttt ttagtttact taaacttgtg ttttatcagc tttttagtat 121080 taaagttctg acttgggatc aatttcctcc aaccctacaa taaatctcag tttatcttta 121140 attttaaaag agaatgttgt tttctttttc tgttaagcct ccctgttaag taatagcagc 121200 aagtttagtt tggccatgaa tatcttctag agattgtatc ggggtactga taaacacatt 121260 tgtagctcag ggatactgca tcagccatat tttaaaatgg gactaacagt ttaaaaacta 121320 taaatattca cagtgttaag aaacaatctc aagatgcatt aagaaaaagg aaggtgcaaa 121380 acagaaaaac aaacgtaaac gtgtgtgcat atgcatgctt atatagtcac atattcttgt 121440 atgtgtacaa aaaatacaca ctggatctct gcaagcatag ccaagcaact ggaaatatgt 121500 ttttaaaaac ttgcttttca ttctatctct tctagtactg ttttgatgct ctttgaaaac 121560 aatctaattg ctgtaacaaa tgaccatacg taggccgggt gtggtggctc atgcctgtaa 121620 tcccagcact tcgggaggct gaggcaggca gatcatttga ggccagggat ttgagaccag 121680 ttggacaaca tagggagacc ctgtctttac taaaaataca aaaattagct gggcgtagtg 121740 acgcatgcct gtaatcccag atacttggga ggcggagaca tgggacttgc atgaacccag 121800 gaggcagagg ttgcagtgag ctgagattgc gacactgcat tccaacctgg gcgaccgagc 121860 aagactcggt ctccaaaaaa aaaaaaaaaa aagaccatat gtaatgtttc ttcattgttc 121920 taagataaat ctttaaggct gttgaggttt tttgtataca aaatggagag taagttttaa 121980 tgggatggga caaaatgagg cttacagttg agtttaattt gagttcacat cctgttgaca 122040 ttaagttgat ttggaacaag tgatatggtc caatgcctgc ttttctattg tctgtggttc 122100 catccactag tgcctgtgtt acacacctct tgttcaggtt ttatcattta aaataaataa 122160 gaataaacag tccatagctt atcttactta ctgaataaat gctctaattt gacagtcatg 122220 tttcttaaag ttccttacaa aggccattgc ccaagaaacc aaataattcc attatactat 122280 ttttgaaata gaacacataa taaatgggaa ttttaagttc agtttcttat gtaaacaata 122340 acttctatgt acatgttaaa tatgcctgta tatacctaat ttgaccatgt atgtatagta 122400 gaaatgaaaa cagttactaa gaaaatttgt tattggctcc aaattttctg aattaagtgt 122460 attctaatgc tcagccataa tatggggttt catgtgttag tttatgtatt catggttaaa 122520 aatgtgaaga ctgttatatc ttcatttgtg tcttttggta ttatttggtt gtattttatt 122580 gtgtgatatg gtggtataat tatccttacc tcccaggagt ttgagagggt cttgccagtt 122640 aaccgcagaa ttaaacatgc ttaggactaa ttaatcagga gcaatactac aattagttgg 122700 aggtaatttg aaacctggtt tcaaataacc ctgatattat gcacacatgg tgcacacttt 122760 tctagtagac atttaatgaa agtaatttaa aacctacctt tgaaggatga aaaacattgc 122820 cttaaatgct ctattctgtg aaagtatcaa catttatgca aatacagtct aaattcagac 122880 tttgaaaatg tattgaaaga gaggatcatg aaataagtta gagctgagtg acaaagcttt 122940 ctgagtgttt aaaagaatgt tttacctaat aaatatctga aatgtatttg gagccacatt 123000 tgtttaaaga actgtataaa tatgtagcac tgttcatgtg aagttcaata gtaggaaaat 123060 gctgacagcc cttgtggaac tgtggttatt attattttat gaatagagcc aatttcaaac 123120 acctattaga gtcttctcag gaacatttta tagaatgcat ctggagcctt atgttatctc 123180 taagcatttt aggatttgtc ttcttggaaa ttcatgtaac caaaccacca tgtgttattt 123240 caagtgtata tagtattggg ttacagttta ctatgttttc agaaggttgt gacaactatt 123300 agacttacag agaatgactt ctctgccact aacggctttc taaagtgaat agagaggggc 123360 gaggattgaa ttcttcggta aagctgggtg attttgtttt attcaataca gtataataag 123420 tataaaaagt agaacctata gagagctata atgggggtag ttttaaagaa attctgaaaa 123480 tgaaaaactt aagtaaaggt ttagttcatt gtttatttca cactgagcat ttactacctg 123540 aatgttttgg acattttatt tccatgactg gagtggacac ttttacaact cactgggttc 123600 tttgctgatc tttctctaga agagcatagc tgagagcagg attctgcctc tcatgacaat 123660 tggcatgcac ttatcccaag cggtgaaagc tggctgcccc cttgatttgg agcgagcagg 123720 cctgactcca gaggttcaga agattattgc tgatgttatc cgaaaccctc ccgtcaactc 123780 aggtgagagg catggcctag ctctgcaccc ttaatgactt gatgaagtaa acaagcaatc 123840 cactatattt ttcactgtta acagcattaa tcctttatgc tattatgaaa accttacttt 123900 tgtgattctt tttcttgttt taggaaaaca atctttcttc ccattatcac tcagaggaaa 123960 gtatactgag aaattttttt gttttgtttt gttttttgag acagagtctt gctctcttgt 124020 ctaggctgga gtgcagtggc gtgatcttgg ctcgctgcaa cctctatctc ccaggttcaa 124080 gtgattctct tgcctcagct tcctgagtag ctgggactac aggcgtgtgc caccatgccc 124140 agctattttt tgtatttttt gatagagaca gggttttcca tgttggctag gcaggtctcg 124200 aactcctgac ctctgatgat ccgcccacct cagcctccca aagtgctgcg attacaggtg 124260 tgagccatgg cacctggcca atacactgag aaatttttat tttccttttc agcttaaggt 124320 tacaacttcc ccaccatcca aaacgtgcac tttcattttt tttctaattt ctatctcatc 124380 acttgcaaaa accatatttt tctccacatt cattcccagt agcttcctga ctcctagttc 124440 ttccctaaat ccttctgagt ccttgtcatt ggtttcgctt gagtagcctt tctaatcaac 124500 acagtcattg gtatcagtta ctgtgacatg gaagggacag accaagttct gtgggccgct 124560 acgtagaagg atttcctgtc actttgctgc agaacctcag ctcgcggaga gcaagcccct 124620 ttgcttgccc tgtagaaata ttttaaatta ttatcctttt tttttttaac agaagtaaat 124680 aggagatacg ttagaggatt ttctctccta gatgtgtaaa tacaaacttg gggtcttata 124740 actcaataaa tctgataaat ttcttttgac tgttaggata gagcagtggc cataccaata 124800 gcctcatctc caaagctgca gtgaagatac tttttactac cttaaagtct ttcccatttg 124860 tgaacaactt gtgaacaatt ccccccaaga atttggaaga tcactctctg aaagcacagt 124920 caatactgta cttaaatgga tctgagcaaa aataagtcac ttagaagaca ggattatttc 124980 tagacttgag tgtgacttga ctgaaggtct aaagaacaaa cagctccttc acttccattg 125040 atcacggtgg aagcacaggg aaaggacaga cacggaggca agttggagta gtgctcatct 125100 aagttccagg gatgcggggg agtggccagg ggacttcagg tatagtaaat aaataaccta 125160 tttataagtt atgtcaatgt catgtttgaa atagaaaacc aaatactgca tgttcttact 125220 tacaagcagg agctaaagtt ggtgcatatg gatataaaaa tgagaacagg ccgggcgtgg 125280 tggcttgtgt ctgtaatccc agcactttgg gagacctaga tggaaggatt gcttgagctc 125340 aggagttcaa gaccagcctg agcaacatag tgtgaccccc atctctacaa aaaataagaa 125400 aattagccag acgtggtggc atatacctat agtctcagct acttgggagt ctgagtcagg 125460 aggagtgctt gagctcagga gtttggggtt ataataagct gtgatcatgc cactgtgctc 125520 cagcctgagt gacacccaga gtgagaacct gtctcaaaag gagaaaaaaa aaaaagtaac 125580 agtagacgct ggggactact gaggggaggg aaggaacaat ggttgaaaag gtgggaaggg 125640 acagtggttg aaaaactacg tgttgggtac tatgctcact atctgggtga tgggatcaat 125700 tgtacctcaa acctcagcat cctgcaatat actaatgtta caaacctgcc catgtactac 125760 ctgaatctaa agtaaaagtt ataatttaaa aaaattataa taaaatcaga aaataaaggt 125820 ctgagatgga aaattaaaag accaaagcca cccataagca caataaatcc ctccccccaa 125880 aaaattatat ctattaaaaa aaggtgttgc gccaggcact gtggctcatg cctataatcc 125940 tagcactttg ggaggccaag acgggcagat gacttgactt gaggtcagga gttcaagacc 126000 agcctggcca acatggtgaa accctgtctc tactgaaaat acaaaaatta gccagcagtg 126060 gtggcatgcg cctgtaatcc cagctactca ggagactgag gcaggagaat cgcttgaact 126120 ggggaggcgg aggttgcagt gagccgagat catgccactg cacttcagcc tgggtgacag 126180 agtgagactc tgtctcaaaa aaaaaaaaaa aaaaagacct tgtaccctga caagttttag 126240 tttgtgcagg aatgctagaa tgactcaaga ttggaaaaat ctttaaatgt taattacaca 126300 ataagggtaa aaggagaaaa attacctaat gtcatctgag caacaagaag aagaaatgaa 126360 aggcattaaa aattgggaaa aatttatatt tgacagtatc ttaacaacga attctgcttc 126420 tatatcactt cctagctttc tgatgataac ttcccgtgca gatctgtatg taaggaatgg 126480 acgtagtagt catgctaatc tgagtattta tctgtgtgat acttacgaat taacgatgta 126540 agttaataag ttagcatttc gtgaacctgg ttaataccat ttgctaaggt taaattagcc 126600 aaatcctgaa gtaagctgta aaacatccaa ggtagggtag agaggcatct tatgagaaag 126660 ctggccaact ctcctggtca ccttctaatc ttcctaactt cagaaatcaa ggcagagaga 126720 ggaaaatagt aattactttg taggattaga tttatggttg tcgaaacctt tgtttctcca 126780 gtgcagaatg agatagcgtt ttagggaaag ccaaagactc agatgtcttc ttcatgctca 126840 tcgtgtggaa tttttcttcc tttagaaatg tattgtctct cagggcttaa agcaatttgc 126900 atctttcgat gagacattga gtaataggca atattctctg aaataatttg tgcaggctgg 126960 gcacagtggc tcacacctgt aatcccagca ctttgggagg ccgaggcggg caggtcactg 127020 aggtcaggtg ttggagacga gcctgaccaa catggtgaaa ccccgtctct actaaaaata 127080 ccaaaattag ctgggcttgg tggcacacac ctgtaatccc agctacttgg gaggctgagg 127140 caggagaatt gcttgaaccc ccatgggagg tggaggttgt ggtgagccaa gattgtgtca 127200 ttgtactaca gtctggacaa cagagtgaga ctctgtctca aaaaaaaaaa aatagaattt 127260 gtgcagttcc ccccaccccc tttttttttt ctgttggcat ttttgctatc atttagctgc 127320 cttctttata tcctgaaact tacaggtggt gttggtctag tcagtaagag caaaggcttt 127380 gggaatagat agatctgtat ttagaccttg gctctagcat ctcattgtta tgtgacctcc 127440 atcaagtgac ctaatttccc taatattcaa tttcctcatc tctaagacag ggagttaata 127500 ttgcctctct tatagaattg tgagaaatat agtcatgtgt cgcttgatga tggggatgaa 127560 ttctgagaaa tgtgttgttg ggcgatttca ttttgtggga acctcacagg gtggacttaa 127620 acaaacctag atggtatggc ctactacaca cctaggctgt acggtatagc tcctgtcttc 127680 aaacctgtac agcatgtgac tttactgaac actgtaggca attataacac agtggtattt 127740 gtatatataa acatagtgaa acatagaaaa ggcccagtag aaatacagtg taaaagattt 127800 tttaaaaaag ctgggcatgg tggctcacgc ctgtaatccc agcactttgg gaggccgagg 127860 caggcagatc acttgaggtc aggagttcaa gaccagcctg gccaacatga tgaaactccg 127920 tttctactaa aagtacaaaa attagctggg cgtggtgttg ggtgcctgta atcccagcta 127980 ctcaggaggc tgaggcagga gaattgcttg aacccaggag gtggaggttg cagtgagtca 128040 agattgtgcc actgcacttc agcctgggag acagagcgag actctgtctc aaaaaaaaaa 128100 aaaaaaaaga gataaaaagg tacatctgta cagggcactt accacgaatg gagcttgcac 128160 cctgggagtt gctctgggta agtcagtgag tgagcggtga gtgaatgtga agacctagga 128220 ctgtgcactg ctgtagactt tataaaccct gtgcacttag gccacactca cccctgtgat 128280 acgagtctac ctactgtata acgtacctgc atatgtaccc ttgaaactaa aacaaaagtt 128340 aaaaaattta tcttcttttg ccaataataa attaacctta gcttactgta atgattcttc 128400 tttatgaatt aaaatctttt tactcttttg taataacact tggcttaaaa cacaaacata 128460 ttgtacagct atacaaatat attttcttta tatccttctt ctctaagatt ttttctgttt 128520 ttgattttgt taaatttgtt tttacttttt acattttttt tgttaaaaac caagacaaaa 128580 acccacacat cagcctaggc ctacatgggc tcaggatcat cagtctcact atcttccacc 128640 tccacatctt gtcccaccag gtcttcaggg gcagtcatat gcatggggct gtcatctcct 128700 gtgataacaa tgccttcttc tggacacctc cagaagggcc tgcgtgtttt acagtgaact 128760 tctaaaaaat aataaaatgt atagtatagc aaacacataa acatagtaac atagtcattt 128820 attatcattt tcaagtatta tatactgtac ataattgtac atgctagact tttacacagc 128880 tggcagcaag gtgagtttgt ttacaccatt accaccacaa acacatgggt gatgctttgc 128940 attgtgatgt tacgatggca tgatgtcact aggtggtagg aacttttcag ctccatgata 129000 atctaatgga tacttgttcc tgttggctgc ccgtcgttga ctgcaacatc attatgtggt 129060 gcatgactgt aaattagata ctgttcagaa agctttggca cactggtaat agcaaatggt 129120 ggtggcaaat atgatgatga tgatgatgat gattgaagac atagatggta aaattttatg 129180 gtgtcttaaa agtaccctct aaatatgatt atttttatag tctgtccttt tgaataggca 129240 cttaagaatg tatgaactta ataagtatat aagaaagaat gttccccaaa atatatctta 129300 cagaggcata caatttaaga attcaaacag gttgtaatgg ggtgtgtgtg tgtgtgcaca 129360 cgcgcacgca tgcgtgctca ttcacactaa agaattcttg ggcatatgtt cctgaatgtc 129420 ctaaatggac attctaacat cacttcatta tgggcagagg gaaatggtaa agaaaaattt 129480 catattatat tattcagcca catattgaca gcatctgttt tatttgccta tggtaaagaa 129540 ttgaagcact gttaatttgc tttttaaatc atgtaggcac aaagttatcg aactttagat 129600 ttagaaatga aactggaaat cattacactt tccctttcct atccccaccc tgttttggag 129660 agaaagagtg tgaggcttag agagttataa aactgtttta ataccatgtc taagattaat 129720 aactgaacaa gtttctcttt ttactcgtgt taaagttgta ctgccaatta acttaaaaga 129780 aagaaatatg caatttctaa tcctgatata ggatatgggt atataaactc taacttgatg 129840 agtgaaacaa attaacttat ttataatcag tttcatatct ttatttattg agtgtcttta 129900 aatacccctt acctttaaag taagaaatat taaaatcaag cagaatataa taatgaaaaa 129960 ttcttaagat atacttacta aaaacttatc cttcggttaa tacactgtat gtaggttgta 130020 catacaatat gaaaaagtat atttttgtag cctactttta aatccagaat agaggaggtt 130080 aagaaggttg tgataaccat gagctctttt tttttttttt ttgagacaag gtcttactct 130140 gtttcccagg ctggagtgcc gtggcacaat catagcttac tgcagccttg aactcttggg 130200 ctcaagcaag ccttccactt cagccttcca agtagctggg accacacctg gctaattttt 130260 aagtattttt gtagagatga gttctcacta cattgcccag gctagtcttg aacccctagc 130320 cttaagcgat cctcccacct cagcctgcct aagtgctggg attacaggtg tgagccactg 130380 agcccagccc tcttttattt cttttgatag tacactcata atcattaaac tatcatttct 130440 ggatgtgaga ttgtgctttt ggattcttat tttttcttta taaaatactt tttgttctct 130500 tactggagaa aacattgttg gattataaat gatataacaa ggaatgagga tatacatact 130560 ataataacga ttcagatatg ttattttcat attttattta actgtagcca tgccacaata 130620 atttagagtt ttaaagaaca agtttgattg aaatctaaac tttgtacaat cctgaattga 130680 gaagtttcct gtattttatt atgacacaat atttacctaa aaatagagta attatgaatt 130740 gagaaaacat agctattaat ttcatactct tatttgttaa gtagattttg tctggaaaac 130800 tgttcatatt taaaggagct ttgtaccttt gtattctttt tgtttttcct tgtttatata 130860 attttaaact ctgtttatgg atttgggatt ctaactatgc taaataataa attaaggcat 130920 tgaatgaagt acctagacag tattttgatt aattttattc ccccattctt aatgtgcatg 130980 taactggaaa attaagagtg gcttccaagg gatctactac aaaagtaagg ttaatatgat 131040 ctcttttaaa acactgaagg cgtgtagcca gtgttgtcat taattctgca gtagatattt 131100 tcagcactta tttacatggg aagttagagc agagtaagat gcacctgtaa agctaaatgc 131160 cacttatttg catatatata aaacgcagga tgaatttacc atagaaatat aaagggtact 131220 tatagaaatg tattagaaaa atatatgaat ttttaactta tatctagaag ttaactttat 131280 acatttaact ttaaatcatt aatagtggtt taacaccata agcggatgtt tatgcatcat 131340 cattttatga acaaaagaca ttctaatttt agaaataaag tgattcaaaa gagaataaaa 131400 tatcttactt tttcttttaa aattaatttg tttagcgcat tacatgataa tagctcaagc 131460 ttgtgtgatt tttccctaaa aaattggttt ataaatatta catttatagt atgaagaaat 131520 taatcataca tagtttattt atctaatttc taaataccca tggaagaaaa tgaatttaat 131580 ggaatgtagt tgtgtattac ttggtttcga gtgtgggaaa atttatatgg tctttctaaa 131640 acagcactgt cagtagaaat acaatgtgag ctacatatgc aattttaaat tttctagtag 131700 ccacatttta aaaagtaaat ggatgcaatt tattttgata atataattta attagtctac 131760 tatatttaaa attttatcat ttcaacatgt aatcaatatg aaaattatta atgagatatt 131820 ttacatactt ttttctgtaa taagcctttg taatcaggta tgtactttat atatacaaca 131880 aatcttctga tgctaaattt taactggaaa tacttgatct gtgtttagct tttgtaaaat 131940 ttactgttga acaacgtgga ctaatgtgcc taagtggttc caaacatatt ttaaaatttg 132000 aagacaaata aaagggaact caaagtaaat tgggatacat acatacaaca gaatactgag 132060 ccattaaaaa atgatgaaat agtaaaattg ggggaatttt gatgatacta ggatgatata 132120 atgaccaaga gacaaataca attttagttt ggttgagaga tgtgatcatc acgttgctga 132180 ttttactatg tatagaggtt atcttttcct ttctaagatt ttgaaacttt aattagttaa 132240 cccacttacc tagtttctat tagctgtgta actttctctt cctgtttttt gttttgtttt 132300 gttttgtttt ttgcttttta actgcagtat tttgaggagt cttggagtag caagctaatc 132360 tttggaagaa aggaaaatat aaacctgaaa actaacaatt taaagaacgt cttttcaggt 132420 tgtcatttga aaaatacttg atttctgatc actgatttga attgagtgtc aaatatttga 132480 tatgttttgt aaattaggtg aagatgagtg agtaggttct aaactgcttg ggtttaccgc 132540 actctggagc attgcagaag aatgtgatgt tggaaggaag tgctgaaaca taattattgg 132600 cttgcctata ggagggtgct acataatttt agaaggtgtc aagaaattga cacagtctga 132660 attagttctg ttgagttgca aaaaatgtaa agtttcttga ttctgaaaat aagaaatatg 132720 ttcccagaaa tctcatctag ttaatgtgct tttaaaatca ttgatgtctc ttgttattac 132780 aataatagcc attgaaagaa tcttttttat tagaatgtta tttacaggta cgattagctt 132840 ctatttaaat aaattatttt tatacttgat cttaggcaaa aggccaacaa gtgatcagaa 132900 taaattattt taagagaaaa ctaattataa ttgatatttg gaattggaag cacaatttcc 132960 tttagaacaa ttccacgaat ggttgttttg attctcaagg cagcccacaa aagacagttt 133020 gaaacacaat ttatgcagtg tcaatagtac tgacctgact ttggatcttg gaggcagggg 133080 cttcaggtga tacccgagtg gagtttttac tccatttcca ttccgtaagg ctataggcat 133140 ttgaaagagg aaacttttct ttggcaacct tccaccttcc tttctacaga atatttcagt 133200 atttctagct cataggtttt ctaaaatatt ctctgtaatt tattttgaaa tggagttttt 133260 ttatcgttta cagatatgag taaaattagc ctaatcagaa tgttagttcc tgaaaacatt 133320 gacacgtacc ttatccacat ggcaattgag atccttaaac atggtcctga cagcggactt 133380 caaccttcat gtgatgtcaa caaaaggaga tgttttcccg gttctgaaga gatctgttca 133440 agttctaaga gaagcaagga agaagtaggc atcaatactg aggtattaat tatatataga 133500 attttcataa agtgtcagtt tgttcaattt gcatatccta gtactagaat gctgtatttt 133560 tttgaactgt tatgaattct gatatgatta ctttctctat gtgctacatt tcctttgctt 133620 ttcataaata tgatctgaga aaagtgatta aaaaaaagac agtaaaaggg aggtttagtc 133680 catctgttta gcttattatg tagaatgtca gcttaaattt tacctgtacc tcatattgac 133740 cgtatagcct ggaaaatctt tcggaggtat agttaatgga tttaagcata tggcagttta 133800 tgtagttaat gaaagtgaaa acaaattgta ttataaatac ctcccaaact ggtttattat 133860 cattctatca ttcttcatgc tctgttagta tgatattgaa tatctgaggt accaggatta 133920 ttgttgcttg tggctctgag catttcgtag tgcttttgca tgatgagaga aagattacaa 133980 atttagtatt atgttagatg gtacgtttta ttaaaatcaa atgcttcaaa aataattgct 134040 ctgtgtatgg catgagataa atagcaatca gatatattgt ttaataatat gactctatta 134100 aatgatggca taaatttgaa aatttgacct tcggtatctt ccgggtctaa aattatatga 134160 ctccattata aatattttgg aaatgattaa ctaaaaaatt gtttcaattc ttagttggta 134220 aattcaatgt ggtagtaggt ggtggtgatt attttgtatt agagaattag gaattacact 134280 tagttctaag gtaatcttta taggatgtcc agcaattaaa cccctacttt tttgaattgc 134340 ttaaaaataa gggaactgat ctttttaaat tctgtacttg agttacgtct gtatatatag 134400 tcatgtccta gataatctaa tggaacttaa ttagttggaa atctttatat tgtttataac 134460 tgaactagct ataagaggaa cattaaagaa aacatatttt gagtggaggt aatgaaattt 134520 agcttctaat gctcagcctt ttatttctgt aatctatacc agatacctaa gaccctctta 134580 ttgtttccca gcttcaacct gtcagtatag aaaacggtgt aacttactat tttttctcaa 134640 tattgaagca catttgtagt gaaatattat tttaactata tattgccatt tttgcttttt 134700 ccctatttca gtaacatttt tcgctatttc agtaacatta catgtcaaca agagaatggt 134760 gggtattttg gggggggttg ggtggggaga aattttacta agcttgctag attctaaaag 134820 gtatacctta tttggcccct tttccccatt taggggaaca agggtgttgg ggctgggaag 134880 tagataagag gtgagtaagt catccaaagc atatgtcttc attagcctcc ctgtatgaaa 134940 agctgatttc tgtagagtgt tggaggccta ctttcagaat ctgtcatatg ttaacattca 135000 tcttctctac tgacctgatt tatatccctt agtctatttc attttataat tatgacaaag 135060 gataaagtca ttagaacaaa ttctttttat tagttgacgt attgttgtgt ttatatctct 135120 tgtgtttgtt attaagatgg aagctcaatc atgtccttgt ttaacagaaa ggtgatgtct 135180 tggcattgat aattctgatt caatatccat aggtacatgg tggattcttt aaatatttag 135240 tattctttta tttctggaaa gttttcttaa atgatagttt ttttaaaatt tcatttctat 135300 aaagttttct taaatcatac tttttagtgt tttattccat tacttcatat ttcttcttca 135360 ggaactcctg ctatacatgt atgttggatc ttcattaccc agcttcaata tttttcactt 135420 ttcatgcatt ctttttattt cttcatttct ctttaaattt ttttcttcct tttcaccttc 135480 tatttctctt ttaacataat tgtatttatt tctgtattcc acatagctta gtattcactt 135540 attttaaaat tattttaaaa cgttttttag atttaaaaat tcttttttta tttatatata 135600 catattttat ttttaccaaa ggagcaacac tattaactga agacttctat aatttttttc 135660 ttttatttct gattctttct tcggttttcc ccctcagttt tgaacttttc taattttgat 135720 ttgtgatgtc cttttgtatt ttagataatt ttcctaatgt tttccagctc atttggaaag 135780 gctacagttt tattctgtac ctaagcaagt ctttctggtg tcaaagattt gaccttgata 135840 cttttctttt gctcattttc gtatgagatt agttttcctg tactttcaaa agaaggcgtg 135900 gttcaagatg gctttcccaa tttcacatct gtctctaatg tttttgtgta atgtctaaaa 135960 tatggaaact tggtttatga gatctactct gccattttta tctgggcttt ctcttccttt 136020 tgtctctgtt gtacctgtcc tgcttggttt tgatttaacc ccagtggttt ctcctgaatg 136080 tggagccttc tcctagaagg cagcctcggc tagtcccagg gttcagagta gccagctgct 136140 ctcttcacct aagagaccac tgtggattcc ttgtactcac ttgctattgg cttggacaaa 136200 agccctccca ttttcagatg ctattatcag attaatctct cattaatctg tctttccagt 136260 gtatgcctgt gggctatctt ggggttctct tgttatcaga cacctccctg ctggcctctg 136320 ctttctcccg tacagatgtc agtactgtgc aggtcttaat tgctgttggt ggtttgcccc 136380 tacattctta cagttttagt ttcccaagga tacctttaaa cttggtttta ttgtaaatgt 136440 cgacaatgga ttttgggttt tactatctag ttctgtctta attctggaat tcagaaagat 136500 taaaagctct gttgttgcag ctgctgccac ctcttcccag taccctctcc tcctatgtca 136560 tttttttctt cttatttttc ttgactgtat aagagagaat gtatgacatt tcctgcttga 136620 ccgctgagtt tgattataaa ttaaaataca caatatttta tacaaattgt tttgtagaag 136680 atttatttac agatgctcat tcacaggtaa aattgactta tgaaaatagt tttcatgaca 136740 aatgtatcag gctcggtaac taaatatatg gattgatctt gtttataaat gaaattaaat 136800 gtgaatgtaa cttacatatt tctgtatttg cttacatccg tatgtacaca tataatcagc 136860 aaatgagttg atgtttccta ttcgtaactt aatggtaata gcttggtaac agagttggga 136920 gtattaaaaa gatgtaaaga gccccttaaa attttgttgc tgggaatttt agtgttctac 136980 tgatgaagga aatagacact ggaaggcgtt gtttctatta ggtaacttag atatcatact 137040 gaagacttca aatacttatt gttgacactc aaaagacaca cttagtgtaa gtaagcattt 137100 ccccgctttt cccaatgaaa taagatcatt attataattc cattataaat gctgatgatc 137160 atatttatag aaatatagaa gataagactt gaaatgatat tcgctaccaa ttaatgagtt 137220 tgaagaagaa atcaggatgt gttttgctat tttacattta ttcttattta actccaaaga 137280 attcagtgat gttatgtact attatttcca tttctctgtg aagacgttga agcttaagta 137340 acacgcataa taaggtcata catttagcaa gtggctcaat taaagttcaa acctggttct 137400 gcctggtttc aaagtctgtg ctactccatg gtattaggct acaacatgac ttagggtttc 137460 ttcctctgct ctattgctgt tcagatgtac tcctcttttg gcagagtggg agaaaatttt 137520 tgcaatctat gcatctgaca aaggcccaat atccagaatc tacaaggaac ctaaacaaat 137580 ttacaagaaa aaaaaaaaaa cattaaaaag tgggcaaagg acttgatcag acacatctca 137640 aaagaagaca tttatgtagc caacaaacat atgaagaaaa gctcaacatc actgatcatt 137700 agaaagatgc aaaatgcctt ttctgtatgc caccttatat ccccagtatt tattatttct 137760 aagtcatagt atcttacagt gtatataagt ctcatccgtt cttttgattt tctcttccct 137820 gcttgcaatt gggtacctag gaacaaagtt gcaatcttag ccagtttttt ctttagcctt 137880 tgctgatgtg tgaaaagccc ttttttctac cctggatttc tgtacttaag ctggaacagc 137940 taagttttta ccttttttaa atataaagtt tcagagtctt ctgccaagga tcttttgctg 138000 ttttcctact gttaaatatt tcaaagcctt ttttaaacat agggaatata atcaaacata 138060 gcaagcagct gatgaacaat atctagatag tcttcattat tgaaatggaa taaatggtat 138120 ttttgtattt taggctaaca gacaccttgt accttagata aggccaacct tctcataaaa 138180 tccctcagtt acttttatta ataataacca aattaactct ggattccagg gtgtactcat 138240 gatggaatga tttctctgtc atgttatcct gaggatctag tactctgaga taacataagt 138300 gtatgacact ttaggcttat gaaacactta gctacttaaa ttatttaatt ttttttcatg 138360 tgcagatggt attgtaccca aacactacct ttgtgtgtgt gtgtgtgtgt gcctgtgtgt 138420 gtgtttttga gacagggtct tactctgctc aggctggagt gcagtggcgt gattatagct 138480 cactacagcc ttgacctcct gggctccagt gatcctgcca aagtgttggg attgcaggcg 138540 tgagccacct cacccagcct taaattattt ttttttcaag gatgtttaac ctgagggtta 138600 gaggctcttt ggcacgtgag ctgctgaaat gtgtgtgaaa gtgttgtgca cgtgtatgtt 138660 tctctttttt tctgggaagt ggatctgtag tgattcttag atgagtctat gagacaagaa 138720 acttttattt ttttcattta tttagcgaat gtttgttaag cgtactatgc cttggccact 138780 ctacagggtg ctgattggac cagtctgtct acctaccgtt gtagatgtta gaagctatat 138840 tcttttcaca tgcctaatat aactctttgt gtatgtatac atgcccaggc atgttccttc 138900 ctcagaacat taaattcacc attttggtca actcaaagca agtacaccat gggacacaga 138960 tctgaaataa tgtccagatt tttacttact gaatgaggtg tgttgagtgt ataagactac 139020 atgatgagat ggcaagtaat tgcctgaaga aatgatgtag tgattttgtg tgtcttatat 139080 ttatttactt tttgatccag aaataaatta tatagatacc actattttgt ttggatgggg 139140 gagaaaggat gggtgtgtat tcaggaactt atgttacttt tttgcaacta ataccccttc 139200 tcagtagtac aaagatttga tttctttttc tttctatttc ctacagactt catctgcaga 139260 gagaaagaga cgattacctg tgtggtttgc caaaggaagt gataccagca agaaattaat 139320 ggacaaaacg aaaaggggag gtctttttag ttaagctggc aattaccaga acaattatgt 139380 ttcttgctgt attataagag gatagctata ttttatttct gaagagtaag gagtagtatt 139440 ttggcttaaa aatcattcta attacaaagt tcactgttta ttgaagaact ggcatcttaa 139500 atcagccttc cgcaattcat gtagtttctg ggtcttctgg gagcctacgt gagtacatca 139560 cctaacagaa tattaaatta gacttcctgt aagattgctt taagaaactg ttactgtcct 139620 gttttctaat ctctttatta aaacagtgta tttggaaaat gttatgtgct ctgatttgat 139680 atagataaca gattagtagt tacatggtaa ttatgtgata taaaatattc atatattatc 139740 aaaattctgt tttgtaaatg taagaaagca tagttatttt acaaattgtt tttactgtct 139800 tttgaagaag ttcttaaata cgttgttaaa tggtattagt tgaccagggc agtgaaaatg 139860 aaaccgcatt ttgggtgcca ttaaataggg aaaaaacatg taaaaaatgt aaaatggaga 139920 ccaattgcac taggcaagtg tatattttgt attttatata caatttctat tatttttcaa 139980 gtaataaaac aatgtttttc atactgaata ttatatatat attttttagc tttcatttac 140040 ttaattattt taagtacctt tatttttcca ggatgtcaga atttgattct aatctctctt 140100 atgtagcaca tgtgacttaa tttaaaacct atactgtgac acagagttgg gtaaacgatg 140160 attatttaac tttaagcagt tcaccatcca tttcaaagcc tttgattggc ttttttgtaa 140220 ataaaaataa cttgttaaga aacaaatata tctgtcatag aagaactaga aaatccaggg 140280 aagtgagaaa aatgaaaata aaaatcattc atagttttac tagtagctaa tcacagtcaa 140340 cctcttttgt gtatcccacc agactttttt atattcattt gtttttagtt aaaatataaa 140400 agtctcgtat attcccattt ttctgcattg cattaccaga aggtagtggc gcctattaaa 140460 tatgtgatat gttgttgtcc agccatggct tctgcatttg catgcttttg tgtgtgcatc 140520 tgcaataccc tgtgaatatc ctgtgtgatg gagtggcaag tacgcacaga cacgtctgct 140580 gcatgcctag gtacgaggct gtctccagga gaagcacttg tttgattatt tgagttgcca 140640 attgaatttg ctgctttttt tcatggcttg ccattttcac tgaaaagaat gactaatgaa 140700 aaacgatgat tggttattag atttggatgt ttggcagaca ttttctcaaa attgaactaa 140760 gttggcctct tcacggaaaa caactggtat ttgttgtgcc aatgataaaa ttggagattt 140820 ctagcaaaat gtataatttt ggaaaagttg tgttcctcca ctggaagctt gacagctttc 140880 cttaacataa agacttctct ttctcttcgc tttcactact actactacta attcttcttc 140940 tgattcttct tcttctcctt cttccttctt ccttccttcc tcctcctcct ccttcttctt 141000 cctcttcctc ttcttctttc tctctttcct tccttccctt cccttcccct tccttccttc 141060 cttccttcct tcctccctcc ctccctccct ccctccctcc ctcctttctt tttctttctc 141120 tttctttctt tctttctctc tctctctctc tttctttctt tttctttctc tttttctttc 141180 tttcaagcag tcctcccgcc tcagtccccc aaaatagtgg gattacaggt gtgagccacc 141240 atgcacagcc ttacataaag ccttttctaa tgagatggat agtaattaac aaatgtgagt 141300 ttttgatatt atataaagat tttttctgtg tttcgaagat ccgtataact cagtgaatca 141360 gtatgttctg gatgactaat atgtgatgtt aagaaatcat gactgaggcc gggcgcggtg 141420 gctcacgcct gtaatcccag cactttggga ggccgaggcg ggcggatcac gagatcagga 141480 gatcgagacc accctggcca acatggtgaa accccgtctc tactaaaaat acaaaaatta 141540 gctgggtgtg ttggtgcgtg cctataatcc cagctactcg ggaggctgag gcaggagaat 141600 cgcttgaact caggaggcgg agattgcagt gagctgagac tgcgccactg caccccagcc 141660 tggcgacaga gcaagactcc gtctcaaaaa taaaaaaaga aatcatgact gggtaaaaga 141720 tctgttcaga gtacaagatg gaccaatgga tttgatatat ttgaatataa cagagtatga 141780 aaaagtttat tgatatagtt tcagattaca cactgcaact aatctttaag aaactattac 141840 ttgtccactt tttggtaaaa tttcagagaa caatgtccac cattatctga acaggctatt 141900 aaaatactct tctcttttcc aactacgtgc ctgtgcaaag tcagattttt ttcatatact 141960 tcagccaaaa cagcatatca aaatggattg aatgcagaag tagatctgag aatacagcca 142020 cttttgttaa gccagacaat gagatttgca aaatgtaaac aatgctgctg ttctcagttt 142080 ttaaaaatat gttttttaaa agtatttatg ttaatgtgta cttggtttac tactgctatt 142140 tttaaataaa acaagaaaca tttttaaatg tctgttttaa tttctaaagt ggtagtgata 142200 gatataaccc atattaataa aagctctttg gggtcctcag tgattttttt ttaagagtat 142260 ggaagggttc tcagacctaa gagattgaga aatgctgatg taatgtttta ttataaaggt 142320 gtaccatgaa ttatgtacct tacttcatat tgttggacat taaagttgct ttcagttttt 142380 ttgttttaaa 142390 <210> 4 <211> 142390 <212> DNA <213> Homo sapiens <220> <221> gene <222> (1)..(142390) <223> c.3233+1G>TiExon26 skipping mutationj <400> 4 gcaggaacgg gggcggggac ggcgctggag gggcgggtcg ggtaggtctc ccggagctga 60 tgtgtactgt gtgcgccggg gaggcgccgg cttgtactcg gcagcgcggg aataaagttt 120 gctgatttgg tgtctagcct ggatgcctgg gttgcaggcc ctgcttgtgg tggcgctcca 180 cagtcatccg gctgaagaag acctgttgga ctggatcttc tcggggtaaa gtgtcttcct 240 attcccgttt tcccagctcc gtgccccggg gtatctatag tgctaggctt ctgagacacg 300 tggaggcgct taggcccgcg gagcaggccc ctgggctgtg tttgggagat tctggaaaaa 360 cagactttct cccttttcct ttcccctctg gagcagctgg gaaaggcgtc tctcggagct 420 tccgccattc agaaagtgtt tccccgcccc tgacggcccc agcttgatgt ttaccttgcg 480 cgcttagtta ggattgctct ttctagtacg gcctttatta tggcagaaat tgagccacta 540 caggtctgca cagcaaagtc gagggaaata acctgctgtc tatgatttag caagtgatga 600 tggatatttt tgagttcaaa tcactcagtc tttaatggat tttcttttct ttttttccta 660 gttgaatctc agttgttctc aggctaggtt tgatatgaaa aatactactc cctattgaag 720 agggtaatat aattcttagg atgctaatac aggagtctgt aagtcggagt acttcaggct 780 ttttatggtt cggtacattt ctttttaggg gtgggatatt gggataagta ggacagttca 840 gatcttgatg tcattgaata gtggtgtcta cctaaaagga agaggctggg gcacaaaatt 900 ataatttaaa gtgtttactt cagccaaaat gaggacagct gcccaggact catttcccag 960 ttgccttggg gagtgctcct tcagccttgg ttacaagcag gtttttaaag gcgaagggga 1020 agagtgggct gagacaaagt tggtcaggaa ttgttattgg tttacagaga taccattgct 1080 tagtgattgg ctgtacactg taactcatag ggtatgagtt atcgtgtcca gcatatggca 1140 ttttatggct tcttggttcc agtctagagc ccatatagca ggtgggcttt aagagataat 1200 tatccagctc agaccgggag tgagacggga ctgttttttc attctaatgc ctctctgggc 1260 ctgataattt aaaggggctt gcattcttca gctaaaattt tattttcttt tatttttttt 1320 cccccacagt ggtctccctt tattaatcca acaaatgttt attaaggact gctctaggca 1380 ctagagatac caacaatgaa caaaacagac aaacatctct ctccttttgg agcttacatt 1440 ttagtggaaa gagacaggca aaaagtaaaa ttataggatg acagaaggtg aaaatagaga 1500 ttaaaaagga aagggggatg aagagtgtgt gtgtgtgttg tgggtggggg gctgtaggga 1560 gctgcagttt tacaataagt ggtcagggac gtcctcgctg agaagggaat ttttgagtcc 1620 agagctcaag gaagtgagag aacttacctt gacgttctct ggaggagaag aaagtacaaa 1680 ggccctgggg gaacctgcct ctttatgttc agagagcaac ttaagaggcc tagtgagctg 1740 gagcagagcg gagaggaggt cagaggtcag gccagaaagg gaaaggggcc agaatgtgta 1800 ggactttatg ggctatattg aaaattgggg ctttcattct gagggagatg ggaagctgtt 1860 ggagagttgt tagggaaacg tgatctgaat tatgtttcta aaaaattgga gtaagatatc 1920 ataaaatttg ccatcttagt cttttttgta tctggccaat tccactcaga attctttttt 1980 aaacagcttt attgagatat aattaatata tcatatgatt cactcattta aagtgtgcaa 2040 tacaatggtt tttagtttgt cttcagagtt gtacaacctt tatcacaatt acctttagga 2100 ctttttcatt acccaaaaga gaatctccat aaccattagt actcaatccc acccgctttc 2160 ctagcaatca cttacctatt tttttgtctc tatatagctc tcaaacccta tgatattcct 2220 tctatctaac tgtatttttg tactcattaa cagcctctct tcattcccac cacccatcca 2280 tcccagcctc tggtaatcac cattctactt actacctcaa tgacatcaaa ttttttagct 2340 cccacatata agtgagaaca tgcgatattt gtctttccct gcctggttta tttcacttaa 2400 cagaatgtct tccagttcca ttcatgttgc tgcaaatgac aggatttcat tctttattat 2460 ggcttaatac tattccattg tatatgtata tcacattttc tttatccact catctgttga 2520 tggacagtta gcttgattcc atattctggc tattgttgaa tagtgctgca ggaaacatgg 2580 aagtgcagat agctctttga catactgatt tcatttccct tgaatatata ccctgtagtg 2640 gatttgctgg acccgcttgt agttctacat ttaatatttt gagttatttc cataatgtta 2700 gtaataattt acattcccac caacagcgag gaaggagttc ccttttctcc acatcctcgc 2760 caacacttat cttttgtctt tttggtaata gccattctaa caggtgtgag gtgatatctc 2820 attgtgattt tgatttacat ttccctgatg gttattgatg agcaatgttt catatacttg 2880 ttggttattt gtatatctcc ttttgagaaa tgtctattca ggtcttttgc tcatttttta 2940 aatatggttt tttaattttt ttattttttt gctattgagt tgtttgacat ccttaaacat 3000 tttggaaatt aacctcttat tagatgtata gtttgcaaat attttatccg attctgtaga 3060 ttctgtcttc agtctgttga atttgctgtg cagagaagca ttttattttg atgtaatccc 3120 tttgtctatt tttgcttttg ttacctttgc ttttgaagtc atatccaaaa aatcattgcc 3180 cagatcagca gtccccaacc tttttggtac caaggactgg tttcatcgaa gacaattttt 3240 ccatccacag gagggagggg atggtttcag gatatttcaa gcgcattaca tttattgtgc 3300 actttgtttc tattattatt acattgtaat atatagtgaa ataattatac aattcaccat 3360 aatgtagaat cactgggagc cctgagcttg ttttcctgaa acttgagggt cctatctggg 3420 agtgatggga gacagtgaca gttcataagg cattaggttc ttctaaggag catacaacct 3480 agatcccttg catgcgcaat tcacagtagg ttttgcgctg ctatgagaat ctaatgccac 3540 cgttgatgtg tcaggaggtg gagctcaggt ggtaacgtga ggaatgggga gcagctgtaa 3600 agaaaaatga agcttcgctt gcttgcctgc tgctcaccta ctgctttgtg gcctggttcc 3660 taacaggcca tggactggta ctaatctgtg gccctggggt tgggaacctc tagccctgac 3720 caatgttagg gagctttttt cctgtgtttt cttcaagtgg tttcatggtt tggggtctta 3780 catttaagtc tttagtccat tttgagttga tgctgtatgt ggtgagagat aattgactac 3840 tttcattctt ttgcatatgg ttatcagttt tcccaacacc gtttattgaa gagcctgacc 3900 tttccccatt gtgggttctt ggctcttttg tcaaaaatca gttggctata aatatgtggt 3960 tttatttctt gggtctctgt tctgttctat tatctgtgtg tctctttatg ccagtaccgt 4020 gctgttttaa ttactagagt ttagtatatt ttgaagtcag gtagtgtgat gcccctagct 4080 ttgttctttt agctcaacat tgctttggct attcagagtc ttttgtgagg ataatgtttt 4140 caaggttcac ccatgttgtg gcatgtatca gaactcgatt tctttttatg gctgaataat 4200 attccatttg tttatattat atatatgcca tatttattta ttcatatgtt gatggacact 4260 taggttgttt ccaccttttg gctattgtga ataatgctgt tattaacatt ggtgtacaag 4320 aatctgtttg agttcctatt ttcaattctt ttgggaatat acctacgtgt ggacttacta 4380 gatcacatgg taagctttta gtttagcttt ttaaggaact gctaaaactg tttttccatg 4440 ggagcagtgt acaagtgttc cagttctcca tatgctcacc aaaacttaat ttcctttttt 4500 aaaaattata gctatcctag taggtggtgg gaagtggtat cttactgtgg ttttattttg 4560 tatttcttta atgactaatg atgttgagca tcttttaatg tgcttattgg ccattatatg 4620 tcttctttgg gaactgtcta ttaagtcctt tgcccatttt ttaattgagt ttttttttct 4680 gttgaattgt gggagatctt tatatattct gaatattaaa cccttattgg gtgtatgatt 4740 tgcaaataat ttctcccatt ttgtgggttt tcttcacttt ttgatattgt tctttgattc 4800 acttttaaat ttttatagag tccagtttat ctgttttttc ttttattacc tatgcttttg 4860 gcatcatacc taattcccaa atccaatgcc atgaagattt tctgttatgt tttcttttaa 4920 tagttttata gttttacttt ttctattgga gttttaagta aattcttgta tattagtgtg 4980 atacatttta agttattttt gtatatggtg tgaggtaggg gtccaacttc actcttttcc 5040 atatggagat ccagttgtcc cagcaccaca tgtttaagag tctattcttt ccccactgaa 5100 tggacttggc acccttgtca aaaatcaatt ggtggtaaat gtatggattt actcctggaa 5160 tctcaattct attctattgt atttatattt ctgtccttat gcctgtacca cactgttttg 5220 attacagtag ctttgtagta agtttagaaa ttgggaaaca tgagtcctcc aactttgttc 5280 ttcttttcaa gattattttg gctatttggg gtcccttgca attctgatga gtttgaggat 5340 caccttttcc atttctgcag aaaagccttt tgatagggat tgcattgaat ctgtagataa 5400 ctttgggtag tattgacatc ttaacaatat taagtctttc tatgcataaa catgggatat 5460 ctttccattt atttgtgttt tctttaattt ctttcagcag cattctgtag ttttcagagt 5520 acacgttttt cacctccttg gttaaattta ttccttggta ttttattctt ttagctgcta 5580 ttgtaaatgc agttactttc ttagtttcct ttcagattgt tcatttctgg tgtataacaa 5640 cagctgatat ttcaacgttg atgttgtact ctgaaacttt gttgaattta cttattagat 5700 ctagtagctt tctttgagat ttttatatgg gattatgtca tctgtatata gagatagttt 5760 tacttcttcc tttccattat ggatgccttt tatttctttt ccatgtctaa tttctctggc 5820 tagaactttc aatatgatgt tgaaaagcag tggtgaaagt gggtatcttt gtcttgcttc 5880 ctatcttagg tggaaagctt tcagtctttc accattaagt atggtgttag ctgtgggttt 5940 tcataaatgc cctttatcat gttgaggaaa taccctttta ttcctagttt tctgagtttt 6000 tatcatgaaa gggtgttgga ttttgtcaaa tgccttttct gtgtcaattg aaatgatcat 6060 gtatttttcc tcccttatct taatgtaatg tgttatattg attaattttc ttatgttgaa 6120 ccacccttgc ctttctgggg taaatttcag tcacttatgt tatatagtcc tttaaattgt 6180 gttatcttat aacagaatca ctctgctact gttttgagca taggccatag ggaaaagcag 6240 gtaaaaggta atatggcttg aaccaacatt gtagcagcgg aagtggtgag aggaggtcga 6300 attttggctt tgttttgaag atagaaccaa cagtatttgc tgacagatta gatgcagaat 6360 gtgaaaggag gagatgagtc aggatgaatc caaggctttt ggcatgagca accagaaaga 6420 tgaaggtgac ttactaagat gggaaatata caaaaggagc agtttgggga aactttatat 6480 ctattgagtg gaatatgcca attagagatt caaatatcca gtaaataatt ggctatcaaa 6540 gtttgaagtt aagaggaatg gtctaggctg tttatataac tttggaagtc attagtgtat 6600 aacagctaat ttaaaagcca gcagactcta agggagtgag tgtagaggga gaagagtaga 6660 ggtctgtgac ttgaatcctg gaatgctgtg atgtttagag attggggagg taagaaggag 6720 cagcagagta tactgaaaag ggattgttat actgaaaagg gattgatata gatggagact 6780 caagaattat cacagaaacc tgataaaatg tttcaagaag atgggtgtga ttaattgtgt 6840 cacttactgc cggtacattg actcagatga gcgttgagaa ttggctatag gatttgacaa 6900 cataaaagtc attggaaacc ttgacatgag cccttttcgt ggagtggagt ggttacagtg 6960 ggtttaagag aggattaaag gagtggaaac agagatgcta ttatagatga ctcgtttgag 7020 tagttttcct acaaagggga gaataataat ggagcagtta gccaaaagtt gagttttttt 7080 ttcttcttct tttttttagt tggaaaaaat tgcgtatatg ttgatgggtc ttttctggca 7140 gaccagtaga gaggaaaaag ttgatgatgt aggagatggg aaaatgtctt tgagtagatg 7200 tcttcgagaa aatgtctttg agtagatgag aggtttgcac acatggagag gttggatgta 7260 ggagtactga tagttcatcc atagttacat aagaaaaggt agatgtatta gagttctcct 7320 gagaaacaga accaatggga gatctttata tctctgtgtc catctctatc tgtatttctg 7380 tctctgtatc tatgaagaga ttataaaagt tttaagatct gccaggagac atacccacgg 7440 gagctaatgg tatagttcca ggccagttgt gaaggcctga gaaccaggag agcctatggt 7500 gtaagttcca gtctgagtcc aagtctgaag gcaggagaag accaatgtcc cagctcaaag 7560 acaggcagag ggagcagatc ttcccttact tagccttttt atttattcag gccttcaaca 7620 aattgaaggc ccacccacat tagggagggc aatctgcttt actcagtcta ctgaatcaaa 7680 tgttagtctc acccagaaac atcctcacag acacacccag aataatggtt agccaaatat 7740 ctgggcaccc catggcccac tcaaattgac acataaaatt aaccaccaca gtagagtata 7800 tgggtacaaa tataattatg tgatatagat ttcagggtaa gagcctgtgg aaattcattt 7860 ttgattgctt ctagtgaaat cggaagcaag atcatcagct aagagtgacg atcggtggag 7920 gagatatgaa gtttaagtgg agaggagaag gtataaaata gtcttaggag gggaggatag 7980 taaatagatt agggaaaagt tgtaggattg ccaggaagta gtaagggccc acttgaggct 8040 ggtggtcaca aatttaaggt gagaccagtc aaaatggttg tgcttttcac ctgctgcatt 8100 cattcagctg cataggtaca ggcacagagt aggtcaagag ttctttttta ttcggggtta 8160 gagttttgcc aggagatagt aataaagcca gaagggcaat gaatttgagg gagtatgcaa 8220 ggaagtggct gttaacttgg agtttaaact agtcaagaag agaattaagg actgcccaag 8280 gggtgaggac aatgatatgg tagcagggcc cttaaaagcc ccagttagat gaaaagattg 8340 ttggaattga gtttctagag ggaatgaact tgaaaaacag gaggtgttgg ttggagagtg 8400 ggatatatgg aattgagatt atggaaggat tcagtcgttg gtaataacat agtatctttg 8460 taggaataaa taggtggagc aggatgcaga caagatcact ggaggagggc tggtcagaag 8520 actgggaggc actatctccc ttggatatta tacatcaaag cttgtgatct actagacaag 8580 tagtggggaa agggtaggat atagatatta atggctatag ttttgatggt gatggtcatg 8640 gtgatgatga tggtccatta acactcaact caaataccat caatttgatt tatatctaac 8700 accacaaagt taggtgttga gttacatgtg gttatattgt aactaatagt cagcccttca 8760 tggacttcta ttctttgatg agactcttct tgtaggagta gtaggtgcct taaagcacct 8820 tttcatagtt gtcagattga aatccttcac cagtgtttta ggttaaccct gttactgtgg 8880 aagtttctct tggctttctg tgtgggctgc ttctttgtct agttttacct tttggggtta 8940 gcatactatt gtgaataatt tattggtgag aaggtaagca gagaagtaga gtactctatg 9000 acctagtaat ttcatatcta ggaatctatc ctatagaaat gataggaatg ccttacaata 9060 cccacatatc cacaagggta ttcattgaac gttatttttg gtgaaattcg caagcaacct 9120 aattatcatc aatagggaat tgttaaatta tgatagataa aatggaattc tattcagtct 9180 tcaaaaagtc agatcaagaa gtggtcttac attttaatta tcccatcctg tcaacaagag 9240 tgtcttcagt tgcaagtaat ggaaaaacca ttcaaactga cttcagcaat aaaaggttat 9300 ttattggtct gtttcatgga gacatctgag gtagagtggc cttcaggcaa gttcactcag 9360 ggatccgact atttttctgg ccttattctt ggccctcttc tatgaaaaca ccttcagggt 9420 ggtttcttgt atgcttgtaa gatggctact tgcatcaacc atgaccacat ctagcaggag 9480 caaaagcatc ctttcccgta ccagaggaga gtcccgaaat ttgttgcaat tggactgcct 9540 tggaagcaat aattatggcc aggagatgga ggctagagaa ctgagacctg atcatagctc 9600 ctatccttga atcagttgta tagcaagggg aattggattt tccttaagac agttggattt 9660 cacctgtagt cttggtgatg aggtcagttc catccataaa actttgctgt tacacatttt 9720 gggatggggt gaggagggct gaatggagat taggatgcta ttgaaatttg ctgtacacaa 9780 tggatcatta tcgtcttctt tcttagtgtt aaggtaatca gcctcttttt cctcctccta 9840 tgcttgactt tactaaaacc atgagacatg tttaacctca ggactccaat ttgaaaaaat 9900 atagactgtt atttacttta ttacttacag aagcccttca tactactctc agcaagaaag 9960 aggtaggcag ggagtgaggg aggggggatc atgcttactg agaaacaaac tatcgagtat 10020 tgaaactccc ccttcatatg cctgacctca gtcccattca gttaccagta ggggccccta 10080 ttaattggta cctcaccagc ttttgctgtt cgttcataaa actgagtcat tgaagtacag 10140 tagaaaaata attggactac aagataactt atttccttcc ataattgcaa aatatctgat 10200 ttttcttctt gtttgtatta tgtaaactta ccctgtctga gggtcctcct ggattgttct 10260 ttgcatttat atatacatag aatttcattt tcttttttct tgtttttttt ttagacggag 10320 tctcactctg tcgcccaggc tggagtgcag tggcacaatc tcggctcact gcaagctccg 10380 cctcccaggt tcacgccatt ctcctgcctc agcctcccca gcagctggga ctacaggtgc 10440 acgccgccac acccggctaa ttttttgtgt ttttagtaga gacggggttt caccatgata 10500 gccaggatgg tctcaatctc ctgaccttgt tatctgcccg ccttggcttc ccaaagtgct 10560 aggattacag gcgtgagccg cttgcccgac cttctttttt tttttttttt ttttttttga 10620 gacgttgaga tagagtctca ctctgttgcc caggctggag tgcaatggca cgttttcagc 10680 tcactgcaac ctccacctcc caggttcaag cgattctcct gcctcagcct cctgagtagc 10740 tgggattaca ggcgcccgcc accatgctct gctaattttt gtatttttat tagagatggg 10800 gttttaccat ggtggtcagg ctggtctcga actcttgact acgtgatccg cctgcctcgg 10860 cctcccaaag ttctgggatt ataggcgtga gccactgtgc ccggccaatt tcattttcta 10920 ttttgaaatt taaactacca ctgacacttc gttttccctc tgttttactt agcatttatc 10980 ttagagaata atcttaatat gtatagttct attttattct tttactggca gcttagtatg 11040 ccatattttg gatgtgtcat tgtttattta cctattaatt taccctataa ctgcttccca 11100 tatttttgct tttacaaagg gatgtaatga acatccttta catacgtctt tgtgcatatg 11160 tgcaaatatt tccataggat agatgtaatt actgacttga aggttatgca gatttaaaat 11220 tttgatgcct tctatgaaac atctttcaaa atggtgatgc cagtttcttc tctcgtaatt 11280 actgcatatg gtcaatcttt taaatttttg ctggtaatga tatttcaaaa ttataaccag 11340 ttttttggcc tcatttcttg aataacttgt tttttctcaa agataagaaa tgtctccttc 11400 atcgtatgtc aaatttccat atttacatgg atctatttct ggacatggca agttttattt 11460 atttattgta tgtatttacg gtgtacaaca tgatgttttg atacacatat acgtagtgaa 11520 atgattccta cagtcaaaca aattaacatg ttcaccacct tccatagtct ctgcagtctt 11580 caaggttttc tctatatggg attagacatg ctatgtctga tctgtttttg tatttttaca 11640 ccaattccac actaattttt tttttttttt tgactgggag tctcgttctt attgcccagg 11700 ctggagtgca atggcatgat ctctgctcac tgcaacctcc gcctcccagg ttcaagcaat 11760 tctcctgcct cagcctccct agtagatggg attacagcac tcgctgccac acctggctaa 11820 tttttgtatt tttagtagag atggggtttc accatgttgg ccaggctggt ctcgaactcc 11880 tgacctcagg tgatctgccc gcctcggcct ccgaaagtgc tgggattaca ggtgtgagcc 11940 acctcacctg gcacacacta ttttaattac tgtagtttta aaagtttcat atttagtagg 12000 gtgagttttt ccttgttggt cttgtttttc aaaaaaaatt tgctgctctt gagtattttc 12060 tcttcccagt gaactttaat gtaaactcac gtggttcaat gaaaaattct gatgactttt 12120 tttcttggta ttgcttcttg agtgtattga tttaattaat atatttacag ttttgggtct 12180 ggctgtgccg aaacgcagtg tgtcttatcc agtccttttt taactgtctt aataaaattt 12240 gctggttatc tttaaaatgg atcttgtata ttttatgtta ggtttattcc caggcaggtt 12300 gtcatttttg ctgttactga ttttggatat aaattttgga tataattgta taatttggac 12360 ttggatataa ttgtatttga ttctgtctta tatataaaaa tgagatagga taataattta 12420 tcctaggata aaaataattt gagtatcctt attttgcatc tggtacctta cttgctcctg 12480 ttaaacaaat agataaaatt acttgtcttc aaagagatcc tgtggaaaaa ttatttattt 12540 taggagactt tggagctttg ataaaaatta ggcttatctt ttgtaaaagc tggttagtga 12600 tagcaatcag actcttttaa aggtgatttt tttttctttc ctttgataaa atgcttaata 12660 tgagggagga ttaagaaaga ggatggcttt tgaacagttt cttcatgggg aaataagaaa 12720 ttagaataat ttcatgttct ccaaaaaaag gagaaaaatg accttccctc ctgagcctac 12780 ttcaagcctc tgtttctttc tgactctatt gttctcatct ctgcattttt ccaatctctt 12840 ctactgttag tgttttaggc tagctcctca gtggagggca gaaattcacc ttctctttag 12900 ctgtctttga aaccaagaag atagaggtat gagatcttcg tagtctgtag taagaataat 12960 agaagccatc agaaaaaaat atcaaagctt tgtagctgct cctggaagtt ttgatgtgaa 13020 gcaggagaca tcacctattg gtacctgact tgcttttgct gttcattcat aaaacagagt 13080 ctctgaaata cagtagaaaa ataattagac tggaggataa cttttttcct tccaggaatt 13140 acacaatcac aaaattgctg atttttcttc ttattcatgt tacataaact tatcctgtcc 13200 gaaaagactg tatttgaact tactatgtaa gatttgcttt aggtaaattt atggctgctt 13260 ccagaattgt gtattaattt tccagtttct tttttaccag tctccacttt tacctttccc 13320 tcttccccct atacttaaat tggtcttact gtaaaattta tgcgtttctc tttctacctg 13380 gcaatgctga tttttttttt tttttttttt ttgaggcaag gtctcactct ttcacccagg 13440 ctatagtgca gtggcaagat cgtggctcac tgcaacctcg aatccctggg ctcaagcgat 13500 cctcccacct cagtctccca agtagctggg actacagatg tgtgccatcg cacctggctc 13560 atttttgtat tttttgtaga gatagtattc gccatgttgc ctaggctgga ctcaagccag 13620 cctcctgcct tagcctccca aagtgctggg attgctggca cgtaccacta catccagcca 13680 gggctgagtt tctgaatcat cattgcagca agagaaattg gattaccttt agaccactgg 13740 ctctactgtg ggctgggagt gggacacctt ccttaaagcg cattggacat tggctttgtg 13800 ggtaactgat ctttacctga atgaaattta tcagtactgt attaagggtc tagggtggaa 13860 cggatgctag caaggcaacc gttaacatcc acttactgat gaatcctata aaattttatt 13920 tcaggccata cgaagtaaca gtaataaata taaaaggaaa aatagacaac ctaagcaact 13980 ttttaaattg acttacttga aaactttccc tgcaatttcc cggtttataa tggttgattt 14040 cagctgactg gctatagcta cttagagaac agaggaaatt cattaaaaat aatgaattat 14100 tcagttgggt agtgaaatcc agttataaag cacttcgctg tgccatggat tcagttcagg 14160 tcaagtgatg ttcctggttt atgggcagtg tggcttctca ctatgacaca gcaaagaacg 14220 tagcttttat cctttaccct tgttactaac taaaattaat ggcattttat tgtgtttatt 14280 tgtttgattc catttacagt ttatttcact tggttttatt agtacaaaat tgtgctttat 14340 ataatatttg acagttagga aaaattgtta gatacctata aagaaacaag tctctcaaaa 14400 atcatcctac tacttttaaa aattacatcg tcttactaca gttaacctag atgtgaatgg 14460 gtagttttat ttagcttttc tggtttgttt gcttggtctg tttggaggga agttaagatt 14520 agcagaaatg tagtaataga ttcatgaaag tcttgaaagc ttctttaatt agagaattta 14580 atgagggctt tggcatgcat tctttggttt ttctctgttt tcctctaccc cttcttattc 14640 tttttggttc attgaaaagt agaaagaaat tctcaaaaac cgtacaggag aataccttat 14700 aaatgatatc ttctgcaata aactatagat tgtatatatg tatatgtatc tagatacaca 14760 atctgtgtgt gtgtatatat atgcttgtgt gtgtataaat gtataaatta gttactagta 14820 tatacgtaag tataaaacct caatgtgcaa ggttacattt tcagaaaata tgtaatataa 14880 taaaagaaat caagcccaga atttttaaaa agtttattgc gctttctgtt aaaaatgaaa 14940 ggctttttga ctggaagctg cttctcagta aaaataacat aattgtgttg gtgaagccca 15000 aagattctaa tgaaaattag ggtattgaca accaaacgga attgctggag tacttaagct 15060 gctttggttt tgtaatcttt ctgtgtcaga atatttgaaa aacacttatt aatccagtct 15120 tgtaacttat ccttgaaatc tcttttttaa tattcttttc cacacacatg aaaagttaga 15180 tgagtgtatg aatttctgtt gtcagactag ttgtaaacct cctaaatata gtttctgcag 15240 tatagttaaa gagaaagaac atcctggcta acacggtgaa accctgtctc tactaaaaaa 15300 aaaatacaga aaatgagccg ggcatggtgg tgggtgcctg tagtcccagc tactccggag 15360 gctgaggcag gagaatggcg tgaactcagg aggcagagct tgcagtgagc cgagatcacg 15420 ccattgcact ccagcctggg cgacagtgcg agactctgtc tcaaaaaaaa aaaaaaaaaa 15480 aaaaaaaaag aaagaaaata ggcccagcaa ggtagctcac gcctgtaatc tcagcacatt 15540 gggaggctga ggtagggagg attgcttgag gccaggagtt caagaccagc ctgggcaaca 15600 tggtgaaact ccatttctac aaaaaataca aaaattagct gggcatggtg gcatgtgcct 15660 gtagtcccag ctacttggga ggctgagtgg gaggattgct taagcctggg gaggttgagg 15720 ctgcagtgag ctgtgactga gcaacagagc tagactctgt ctcaaaaaaa aaaaaaaaag 15780 agatgggttt tgaaattcag tacttttttt gagtgaggtc caatgggtca gaaagaagca 15840 ttggataaat gaatccattt tctcttctct gtttgaattt gtaatttgaa agaatattct 15900 acctataaag tacttcagtg cttaattagc tgtcagtgaa tttatatatc ttatctaatt 15960 catatggatt tgctattttt atctgtacct acagattcct gacctctcta aggggatccc 16020 agtatactat agggaatgag gtataataga agtaaaagac ctatcactag tcctgtcatc 16080 attccaactc atgtgtaatt atagtttaaa agaagtgaca tcatgtgtat tgctgtttat 16140 ctttacatta atcttgtggt caagaaagca aatactataa tatataataa ttatataata 16200 tcataagaca agtaatataa taatgggaat ataatcccat tttacaaatg aggaaatgaa 16260 aatttagaga aataaagtga cttgtccagg gtcacatgga tactaagtga ccaagtgtca 16320 aagcagaatt ttccaaataa cttaaagata attcttgtac aaatatagaa cgaacacatg 16380 tcatatgtgt tgtgttaatg agggaaccag aaggatgaca acattggttc agagagatgc 16440 aaagataaat atagacattg gaggaaaaag ttggaaataa gattgttagg ttagatacaa 16500 agctgtgtta taggccaata aaaaccatag actttgaggt tatctttttt actggacagg 16560 attcagttac acctttatga gaccaaaatt tattatttaa catgtggata ttagagtctg 16620 agttttaaaa ttattagtaa atgaccgtca aataaagata tgtcccctaa tgaaatactg 16680 ataatcgctg ggtgagcttg tgctcctata tgacattgaa atgacatact gccctctctt 16740 tgtcttctaa gttttggata cttttttttt tttttttttg acacaaagct gcattagaac 16800 ctaggtttct tgattttcag tccagatttc tttccactct acttcctgct tcttcatagt 16860 ataattttca acactagagc agtctgcata acttttgcaa aatcagctag tctttcttat 16920 tagttttcct ttgtgcaaag tgatgtagat acagctttct tcttcagaga aacattgtga 16980 aattcaatga atatttgtaa aatttgcata cgtgcccaat gtgagaaatt gaaattatta 17040 cttaagtatt gcaactgttc ttttaggata ttttgtttgc aaatttcaga gtaattataa 17100 atattcttgc atttttattg taatcagtat ttataaaaca gtgtatttca tcacattaac 17160 ctttacatat tttgaataaa atagtattga accattttaa atagtaagtg gaaatttttc 17220 cacattaaac agtataacgg gctaacagag ttaagcattg cattatttaa ctaataattt 17280 tttcctgaac ttcagattat tatctgtatg tgtcatataa cttgacaatt tttttttttt 17340 agtgcttttt aaaaagagtg ggatacttta ttcagtttag ccctcaagca attaggcaag 17400 tcagttacca tggtaacagt aggtattaat ttccttacct agttagaggt tttatgaaca 17460 aagaaatctc tgagttcatc caccaaaacc caactttctc ttgagactgg cctcttgaga 17520 ctggtgttaa atttgtctat tttctagaag atgacactat tctaagtgga aaatacggtt 17580 ctcttgaggt gaatttctac tctatcaaga gtgaagtaga gtatggctta aaagttaagt 17640 gattaaaaag ctaccctttc ttagctaatt tggaatgtaa ttggtcttaa tttttctaaa 17700 ttcgttctaa ccaaaatctt attggcgtga tttctattga catgaactag aagtgacttc 17760 agcagacaac ttgtcccaat atctaaatgc tgtcaaatag aatcacttaa gatgaatttc 17820 ttccaaaaca gagttcacaa ttttgacaga taatctctta gcatttaatt gactagtatt 17880 accaacctta tggaataggt ccactcgttt agctatcatg aggaccattt tgcaactaac 17940 ttatcaaaaa gccttcacca agaagttgca tatcttattg atattttaga atgcgattat 18000 ggagattaaa aatcaccaca atgggttgtt aataacgcca gccttgaact ttcagtttta 18060 gagcatttta tctgtgttct gtagtcaaag ttggtaaggt gtccagtggg tcatgtttga 18120 cttgctgctt gtttttgtac tgtgtgctaa atggtttcta catttttcag tggttgaaaa 18180 gtcaaaagaa gaataatatt ttatgaaatt taaataaatc caggtttcag tgtctatagg 18240 taaaatttca ttgtaacgtt gttatgctta agtattgttt atgacttctt tgctatagtg 18300 acaaacttga gtagttttga caaagatcat ctggcctgta aggcctagaa tagttactgt 18360 ctaacccttt agagaaaaaa attgctggcc cttgttctat agtatgaaaa aatatagcct 18420 tgattattca ttaaaaaatt attttcccat tttattgaca tacttttgtc ccctgattgt 18480 taaaaggaat gcatgttctt atagaaaagt tggaatatat agaaaagtat aaagaacaat 18540 atgaaaaacc atttgcaatt gtgagataac cactaatgtt ttggtataca ttgctccaga 18600 cttacacaca aacacacacg cgtatttatt ttatacaatt agagtctaat tttttttttg 18660 agacagtctt gctctgttgc ccagggtgga gtgcagtggc aagatttcag ctcactgcaa 18720 cctctgcctc ctgggctcaa gtgattcttg tgcctcagcc tcttgagtaa ctgggattac 18780 aggcgtgcac caccatgtcc agctaatttt tgtattttta gtagagacgg ggtttcgcca 18840 tatgcccagg ctggtctcga acccctggcc tcaaatcatc ggcctgcctt ggcctcccaa 18900 agtactggga ttacacacgt gagccactgc gccttaattt tttaatttgc ttttttcact 18960 tgaataatta taagaacatt atttttaatg actgtgtagt gttctgtttt atggatgtac 19020 catacttaat tatttagtca taatttatta ttatgaggtt gataaacatg ataatcagat 19080 tgagctcaag aagctagtta tagggttgca caattaatga atcccaggta cctcgctggg 19140 ttgctgaggc tgctattttt ttcctgcctg tttggaacac tgtgtttggg accaatgagg 19200 caaaagaaat tgaagagctg ccattttcaa ttattctatt agaagataca ttgaagattt 19260 gtcaaatgac atagacacaa cactaatcca gaagattatt taatcaaaaa ggcattcatt 19320 tcagatatga attcataaac atttgtaacg atcctcagtt tgaagaccat atagaatccc 19380 tgaagaactg gaagacacta tttgcttggc aaagagaagt ccccagacca actggggatg 19440 aaatattcaa agagataaat gaatactttg aaacatacaa ggtactatgg aaaaagagtg 19500 gaagtttggg acaggtaatg acaggaagat ataaaagctt tacattaagt tcaatctaaa 19560 actttattcc aagtaacagg ttgtcttatt catggagaag cagttgtaaa ttaaaacttg 19620 cctgtggttt ggaatttcac attaaatgat tacattaaaa attcaaatgg tgaacctaac 19680 taaatccaag ctcctacagt accttctttt cacctttagg tgaagaaatg cggtgagcta 19740 ttttattact gattatgtgg acagtccaaa ggaaggttca taagcgaaaa ggaaaaattt 19800 aaattattcc atgtgagcga ttcttacttt gcagatttgt tgaagtgtag ttactggctt 19860 caaaaagtgg tatccttaac tgacattttg aacacttgaa ttcactcaat aaaaaaatgc 19920 agtgatcatg tggaaaatac attaaggtat atgacagagt ttatggattc agagcaaaaa 19980 ttcagctttg gaaaagtgaa gttaaaatgg ttttttaagt gatgtttaat tggtgttatt 20040 tgaatcctaa agaagaatta atagtactag tagaggaaag tcagtgtgtc tgtgacaaag 20100 ctttagtatt attttgaaat acttgatata aaaaagttca cgtttactca aagcttactt 20160 aaatcatcag aataaattaa catgtttctt aattaaagaa aaggagaagc tattagactt 20220 aaaaaatttt tgcacccttg aaatacatac aatttgaaga gattaagttg ttggaatact 20280 ggttaatggt gaaaaaggag ttttcagtct atgaaagcaa agccttctcc tttgccattt 20340 gcttttttgt agtggttgct atgtagaatt cgaagaaaat attgttaaaa agtcttggtc 20400 aggagtagag tgtagcatga acccaatgca ttttaacgtt aataatgagg aaaaagggaa 20460 tgcatgataa tttcatcaag tcagaaaaaa atggaaaaag aaaaagagga aactgaagaa 20520 agtaactgat gaaagtaagg tgaaagggaa aacaactttt tataccacct gtgaatgaga 20580 ttaattttcg tttccatact gaaagacaaa tatattccaa ttaagccatt caaaataaaa 20640 aacaattttt ttttggtaag agatgggatc tcactatgtt gaccaagtta gtcttgaact 20700 cctgccctca atcagtcctc ctgcttcagc ctcccaaagt gctaggattt caggcatgag 20760 ccactgtgcc tggccaaaac caaaattaag caacaaaaca acaacaacaa aaattccaga 20820 cagcctttaa aataatgata aaggttgaaa aattgtagat agtggtaggt agataagatt 20880 tcaggaaaag tccaaagcaa atcataatac gttattttaa aggggggttt aaaatccttt 20940 aaaggtacaa tgtgaagcat tatgaaatga taaaatacat gttttttaaa aacattaatt 21000 ttattttaag ttccaggata catgtgcagg acgtgcaggt ttgctacata ggtaaatgtg 21060 tgccatggtg gtttgctgca cctatcaatc tgtcacctac atattaagcc ccgcatacat 21120 tagctgtttt tcctgatgct gtccctcctc caggacccag tgtgtgttgt tccccatgta 21180 ttctcatcgt tcggctccca cttataagtg agaacatgtg gtatttggtt ttctgttcct 21240 ttgttagttt gctgaggata atggattcca gttccatcca tgtccctgca aagtacatga 21300 tcgtgttcct ttttatggct gcatagtatt ccattttata tgtaccacat tttctttatc 21360 tagtctatca ttgatgggca tttggttttt ttccatgtct ttgctattgt gaatagtgct 21420 gcagtgaaca tgaacatgtg tgtgcttgta tctttataat aaaatgattt atattccttt 21480 gggtatatac ccagtaatat aattgtataa cccagtaata ggattgcagt gtcaaatggt 21540 atttctggtt ctaggtcttt gaggaatcgc cacactgtct tccacaatgg ttgaactagt 21600 ttacattccc accaacagtg taaaagcatt cctatttctc catagccttg ccagcacctg 21660 ttgtttcttg attttttaat aaacgccatt ctgactggca tgagagggta tatcattgtg 21720 gttttgattt gtatacaaaa aagatttgta tttctctact gatcagtgat gttgagcttt 21780 ttttcatgtt tgatggttgc ataaatgtct ttttttgaga agtgtctgtt catgtcctct 21840 gcctactttt taatgggatt gtttgttttt tttttcttgt aaatttgttt gagttccttg 21900 tagattctgg atatagacct ttgtcagctg gatagattgc aaaaattttc tcccattctg 21960 taggttgtct gttcactctg atttgctgtg cagaagctaa aagacatgat tttagaaaaa 22020 gacatgtcaa agtcatacat gctcaacgac atagcgagta catatgtaaa taaaaaatta 22080 ttttatgctg tgaatttgac cgaaaataac ctttacctcg tcaggaatta caatcctcac 22140 gtatggtaaa ggatttccct attgcaaatt attccacaac attaatgttc tgtgtgcttt 22200 ttatctatcc caagatacaa gtaaatttga caaagatatt aggtttgtaa acaaatttac 22260 gttcaaatct ttgcctggaa gtatctagat agaattttgc atgcaaaaga gtatttacat 22320 ctaaaaaatt acatatttca aattaaaatg attttagtgt tatagataga aggaaagagt 22380 tattgaagtt tatttctgtt ttggcagtgt aaatgaatta cttacaaaat tttagaagtc 22440 tacaggtgtt tttataaagt ttgtgttatt tgtggaaacc tcagttttct ggcattttgc 22500 caatgaggtc tactctaagt atagcagaaa tttgttttcc agctttataa atatatattt 22560 taagattaag aactgatttt acttatataa tctgggatca acttttggct tctcctgtca 22620 aggattttga atttgtgaca aaatatacac ttattgataa ccagtgacat atataaaatg 22680 ctttacaatt aataaagcat atgtatttta catatttttt cactacatat gacgcatgtg 22740 gcaaccccaa gagttgagtt gtacccatcg gcaaactttg atcatgattc tgtgaatata 22800 ggcaagcacc aattgcaggt agaacattct ttttttgagt cccaaaccgt gagaaacaaa 22860 ttacagaaat gtacctttct tttgcattag gacacgttgt agttttgtat gaacactcta 22920 gttttaagca gtatgtgcaa aaacattgca caaaggattt gtgtgttgat tttgggactc 22980 ctgtattatt aattatgtgg tttatttgac taccccacat tttcaagcat aaattaataa 23040 atccataatt ccaggcttat taacaataaa caatctagat agttgaactc tttcttgcta 23100 acattttcta gatatggact gtttggtatt tttctactaa taaagaccct tagtaagctg 23160 ccttctggtt tgatgtcatt gggatgttta ctgggaactt tggtggagat cttgcagtct 23220 ctctccccca gtggtgaaag aatgagttac aaaccagctt tccttcccag tgtacaatag 23280 cgatggagtt tgttctatat ggaaaatttg tttgataaaa gtattcttta aaattttttg 23340 ttccataaat tatcagtatt ttcagtttct gattcatgct tgggatagtt gctgcatatt 23400 gtttaatttt gtcagaattt atattgttaa atatcaaata cgacagacta ccctcaaatc 23460 ataagtagtt aatgtaatta acatcctgtt tcatcatgag actcttcagt gttacattaa 23520 aaactgctac ctcctgggcc gggcgtggtg gctcatgcct gtaatcccag cactttggga 23580 ggctgaggtg ggcgatcgga tcacgaggtc aggagattga gaccatcctg gctaacatgg 23640 tgaaaccccg tcgctactaa aacatgcaaa aaattagccg ggcttggtgg cgggcgcctg 23700 tagtcccagc tactcaggag gctgaggcag gagaatggca tgaacccagg aggcagatct 23760 tgcagagagc tgagatcgtg ccactgcact ccagcctggg cgacacagca agactccgtc 23820 tcaaaacaaa aaacaaaaaa caaaaaaact gctacctcct tattacaaat aggaactaaa 23880 gttgaagttt gaggaatttg ctaagaacta agccttgaac taaggctatt ttatttgagt 23940 atgagtcata tcagggtacg gatccatttt actattaaca aaacaaatat gttctgtttt 24000 ttttttttaa atgcacacac cacgtttgag agattcttat tcactgtatt ttctttaatt 24060 atacttgaat tttggtttac attgaggagt gccctcaaag atattaacag atttttaaaa 24120 aatcctctaa aaaactcatt cttagggaaa tttgttcact tactaggtga ggagcaaaat 24180 aaaaatcctt aatatagaag agctattatc tgtcttcaaa attaagtctt tgagtagatt 24240 tgtgaataaa tctaatagtt ttgctgaatt tacttagatc ttaagacaga ataatcatgt 24300 agaaaattta aaatgtcagg aattcataat gattcatata cccaaggatt ttcattgata 24360 gtgaggtaag gttattcttg agaaagactc aaagtcataa aataatagaa tttcgaaact 24420 accagaatta tacaagtcaa ttaaaatgac tgatttgttt taagaggaag aaatactaaa 24480 tgtataatta ttagatgcag catattgtat ctgttttgtt ttgtgattct agctcttata 24540 acctatgctt ggacctaggt gtcataactt actttaaata tgtatgtttg gttttcattc 24600 atattgacag tactacctct cagttttctt tcagatattg ttttgtattt acccatgaag 24660 acattgtttt ttggactctg caaataggac atttcaaaga tgagtgaaaa aaaattggaa 24720 acaactgcac agcagcggaa atgtcctgaa tggatgaatg tgcagaataa aagatgtgct 24780 gtagaagaaa gaaaggtatg ttgttcattg actattcttt tgggtgagaa atttaattta 24840 tatttgactg tgcaaagagt cagttgttac ttgtaaactt caagtcattg tttaggtcag 24900 agttgctgtt gtctaaatgc accaggacct agttgttgaa agggtaaact ggaataaact 24960 ttaattgggt ttacaaaatg agaattctta ctgtatattt tctctttttc gggttgactt 25020 taccagtttg ttctagttca gataatttag acaacattaa ctttgttgaa ttttttgttt 25080 gccagccggt cttcagcatt ttaaggcaac attattatta cagttgtaat acgaatataa 25140 ttaccagaga aaaaactcag gaaaataaat gcttttatga aaatgggatt agaggtttga 25200 aaataaactt gttaggagaa ataatttcac aatgggatgg ttttttcttt gttaagtttt 25260 ctttatgact tcattagttt ataaaacatt aattgataaa acttagaact ataaattgaa 25320 tgcttcagtg aactttatta tttcagtgaa catttgttat ttgatgtgaa ctttgtgcct 25380 gttttgaaat ttactaaact caaggcatgt gttcggaaga gtgtttttga agatgacctc 25440 cccttcttag aattcactgg atccattgtg tatagttacg atgctagtga ttgctctttc 25500 ctgtcagaag atattaggta agtgatttga atttcctgat tttatttgaa tttggaccct 25560 tagaaggtac tattatggta atgtttgtga atatactgag ttttacaggt gaggtgtgtt 25620 caatagataa ttatttctat gtatacacta tcaccaagtt ttacatttca aataaaagtc 25680 actgaattaa tttgtaatct gtcagtttgt tcattcataa gcttttctat tacttcagac 25740 agtttttttt taactttttt aatatatgtg ctgctgaagc gagcacgaca gttttttaac 25800 tttcagtact taagatgtta tatatagagc tactgaacat actgtgttta ttttaccaat 25860 ttagggaaaa agtgcaaaaa ttatttaacc tttaaatgca cctttatatt tcattaaaaa 25920 tatcaacata gtaatattga ataatggcta tgatcggctc tgttgtgtgt aattagtaac 25980 agttgtagca aatgatcctt aaaaaatgtt ctaactaaac attagaggcc aggcgcggtg 26040 gctcaggcct gtaatcccag cactttgtga ggccgaggca ggtggatcac aaggtcagga 26100 gattgagacc atcccggcta acatggtgaa acaccgtctc tactaaaaat acaaaaaatt 26160 agccaggtgt ggtggcgtgc gcctgtagtc tcagctactc aggaggctga agcaggagaa 26220 tcgcttgaac ctgggaggca gaggttgcgg tgagccaaga ttgcatcact gcactccagc 26280 ctgggcgaca gagtgaggct ccgtctcaaa aaaaaaaaat ccaaaaaaac aaccccacaa 26340 acaaacaaaa aacattagaa atgtctgtta gtacttttaa aggttgcctt gtaaaattag 26400 gactgcaata gtgcaatcta aggctctcaa agcataaaac aagtaataag gaattcattc 26460 agatattttc cgaggtggtt atacctgtct tttaaaaaaa aaattttgtt atatattggg 26520 ttaaaaaaag cagaggtgct gggcacagtg gctcatgcct ataaccccta cactttggga 26580 ggccaaggca ggaggattgc ttgagcccag gagtttgaga ccagccatag taagaccccc 26640 atctctacaa aaaaatttaa aaattagcca ggtgtctgtg gtcccagcta ctcaggaggc 26700 ctaggttttg ggcccgagag gttgaggctg cagtgagcct tgatcacacc attgcactcc 26760 agcctgggca acagggcaaa accctgtctc aaacagacaa acaaacaaac aaaaggcaga 26820 ggtaggttaa gctatttatt aatggtcttc tactggtata gatataagct agaaataaca 26880 ttcaagtgtt tttactttta ctacagttat ctggccactt tgggactcat tatactgaat 26940 tagtttcaca gaggaggtaa aatctgttgt ttatgattac atattaactc taccatttta 27000 ccttcagcat tgctgtagta tgtcatatct gaaggcaatt agcacaagtg acttgaagaa 27060 ttgtagtttt gatgacttat atgtatttta taaaaggcag gcagagtttt tgtgtttgct 27120 ttcccctcct ctggacactt taaatttttg ctaccacagg tttccaacaa tttgattatg 27180 atgtgccctt gtgtaatgtg gttggtgttt atttggcttg gagttcgttg aatttttttg 27240 atctgtgtgg gcttatacct ttaatcaaat ttgaaaaatg tcttcagatc ctttttcctc 27300 ccatcctgtt attcttttct ctttctggga ctcttagtac acacaagttt gattgcttga 27360 tactgtgtca caggccactg aggctctttc ctttcagtct tttcttcttt cttccttttt 27420 ttctttctgt gcttcatttt gaatagcttg aatagttttg tttcctgtct tcaagttcac 27480 ttatattttt ttcttctgta gtgtctggtc tgtttatacc atcctgtgaa tttctttttt 27540 agatactaca tattttgttt atctctagaa gtcccatttg gttcttaatt tttttttcca 27600 ttttggctct cattattcat gtttctttca aaattcttga acatatttag catattttta 27660 atagctgttt taatgtactt gtctgttaat tccattattc tagggttttt ttctttctat 27720 tggatgattt ttctcctgat tatgggttat attttcctgt ttattcctac agctgttaat 27780 tttttttttt ttaattaggc attgtgatct tactttgtgg aatgttagat tttattgttt 27840 tcctttaaag aaaggaactt tgtcagacat ctaagttacc tgaagatcaa ctttatgttt 27900 tgaagcttgt tttcaagctt gatcagggaa agtctacgtt tgcctttagt ctaaaggtaa 27960 tttagcccta taataagatg tgacccttct ggagtctttg tagactgcct ctggtgatca 28020 acgatctctt ctctgacttt tcagaacgtt aatgcctctt acctttgtgt aagtccgtcc 28080 taagaatcat tcagcttatg gttgtttgcc cagccccata gagttttagt ctatgcatgc 28140 ttgtcttcgt attctgcaaa gaccaaagga gtcccttagg gagatttctg gagctctttt 28200 cctgcctagc ttcctcctct ccagaactct gccccgtgag ttccaggtcc ttcagcttcc 28260 agggctctga actctgtctc cccaactcag tgctctcctt gggattcttc tccctgttct 28320 gttgtctgca atgggtccca ggaagaatgt ggggcaactg taaggttcac ccttcatttc 28380 ccttccctta gagatcatag tcctgtactg cctgttgtct agtatctgaa acagttgttt 28440 tatatgtttt gtccaagttt agatttgttt gtggtgggag ggtgagtctg gcctcccttg 28500 ttatatcatg ttggcctgaa gcagaagctg agtttctttt attttttaaa tatagtttca 28560 atttttaaca actattaaat aggcaagtat caacaacaat agataacaat ataatagata 28620 tgcatattcc tcccacttta tcaaatctta attttcttca attttttttt ttttttttaa 28680 tagggtctca ctctgttgct cgtgctggag tgacagtggt gtgatcttgg ttcgctgcaa 28740 cctccgcctc ttgggctcaa gtgatcctcc tgcctcagcc tcctgagtag ctgggactac 28800 aggcatgcac catcatgccc agataattta tatatatatt tttttataga gatggggttt 28860 ttgccatgtt gcccaggcgg tctcaaattc ctggactcaa gcaatctgcc tgccttggcc 28920 ccccaaagtg ctgggattac aggcgtgaac cactgcgcct ggcctgtttt cttcagttct 28980 ttattaagaa atgaaacagt aaaatacagc tgaagccccg tgtttgttct ttctgattct 29040 ccctctgtgc ccctctgaga taacttctat gagttttgtg catttttttt tctttttaat 29100 aaaaacaggg tcttgctctg ttatccaggc tggagtgcgg tggcgagatc atactcaatg 29160 cagcctcaac cttatgggct cgagtgatcc tttcgcctca gcctctcaag tagctacaac 29220 tactggtgtg tgctgccatg cctggctaat tttttattta tagtttttaa agacagggtc 29280 tcactatgtt gcccaggcta gttttgaact cctggcttct agtgatcctc ctgccttggt 29340 ctcttactta aagcactggg attacaggtg tgagccactg gctgctcaca tgttttttat 29400 aatagtactt aataatttta tgtctgaaaa tattatataa tgttattttg cccatttaaa 29460 aactttaaaa aatgctaaca aactgtgtac tctgtaactt gtctttttta ctcaacacta 29520 cgtttttgag aatttttctt gttgatctgt gtagttccat tttaactgtt atatcttact 29580 atgtttcatt atgcaacagt tggttcaatc cattctcttg ttaatggaaa tttagtttgt 29640 ttctaatttt tgccagtagg aacagtgttg caatgcatat tcttaaacat gtctgtacac 29700 atctgagggt ttcatttatt tgtgacaaaa cttgccaggt catagtgttt atgcaccttc 29760 aactagatat tgtcgttgtc aaagtttttt tccaaaagga ttttaccaat ttatacatga 29820 accaccgata gatatcctct taacacgtgg tattctgaaa cttaattttt accaatcaga 29880 tagatgtgaa atcacgtaga cttagtttgc atttctttga cttctagtga gaagtagtgt 29940 cttcacatat tttttggatt tttaaaattt attttttatt tttgtttttc ttagagacag 30000 ggtcttgaac ttttacccag gctgaagtgc agtgatgcga tcatagctca cgctaacctc 30060 gaactcctgg actcaagtga tcctcctgcc tcagcttcct gagtagctgg gactacaggt 30120 gtgtgccacc aagcccagct aatttttaat tttttttttt gtagagacat gctgtgttgc 30180 acaggttggt cttaaactcc tagtctcaag cagtcctcct gccttgactt tccaaagtgc 30240 tgggattaca ggggtaaacc accatacctg gccatatctt ttggatttat tggtcatttg 30300 gattttcttt tgggaattac ctgttcatat ttttctccat ttttctgctg aataatttgt 30360 cttttcttac ttatttttca agaaatttta catattttct ggctgttcat tgtcagttgt 30420 atgtgctcca gataacttga acagtctgtg gttgcctttt aatttttgaa ttatgtcttt 30480 agttatgcag aagtttaaaa ttttaacata aattaattta cactattttt ctcactttag 30540 catgagtcta tcagatgggg atgtggtggg atttgacatg gagtggccac cattatacaa 30600 tagagggaaa cttggcaaag ttgcactaat tcagttgtgt gtttctgaga gcaaatgtta 30660 cttgttccac gtttcttcca tgtcaggttg gtatctctac atttcatttt tatatggctg 30720 ataattgtaa tatgtcaact ttatccctat aaaattaagt tcttttatta gctggccgtt 30780 ctctcattat ctcaaattta tttaagtatt tatgttctac ctgattcact cacattcctt 30840 gttttattta attttcacaa catacctgtg aggcattgac attttttctg ttttagagaa 30900 gagaaaactg aaattttaag aggctaaatg accaggatat gtactgctat tgctagcagg 30960 agtggcattc aaactgatta ttttttcttg tcatttatca atcaggactg tttgctttag 31020 ttaagaaata ctcaaggtca atgtgtttct gaatttaaaa ttactgttaa atacaaattt 31080 acacataaac atggtatgta taagaagtag gacataaatc catcatactt gacagaactt 31140 atggaaataa caagaaaatg ttacagtttt tccccaggga ttaaaaatgt tgcttgaaaa 31200 taaagcagtt aaaaaggcag gtgtaggaat tgaaggagat cagtggaaac ttctacgtga 31260 ctttgatatc aaattgaaga attttgtgga gttgacagat gttgccaata aaaaggtaaa 31320 agcaatatat atataatttt catgatgaag attattttgt gttacacaga atgtactttc 31380 tatctgaatg ttagattttt ttttgaaaaa gcttgttata taatgttttt gtagcaataa 31440 aaaagttcca agtgaatgtt ctttaatgaa aacctttatt tatttattta tttttaactt 31500 ttgtttcaag atcggggtac atgtgcatgt ttgttacaca ggtaaacttg tgtcatgggg 31560 gtttatcata cagattattt tatcacccgg gtattaagcc tggtacccat tagttatttt 31620 tcctgatttt cttcctccct cctcccaccc tccacctccc acagtgtgtg ttgttcccct 31680 ctgtgtgtcc atgttttctt atcatttagc tcccacttat aagtgagaac atatggtatt 31740 tggttttctg ttcctgcgtt agtttgctaa ggataatggc ctccagtgcc atccatgtcc 31800 ctgcaaagga catgatctta tttatttttt ttatggctgc atagtattcc atggtgtata 31860 tgtaccacat tttttttaat gcagtctatc attgatgggc atttaggctg attccatgtc 31920 tttgctattg ttaaatagtg ctgcagtgaa catatgcgtg catgtgtctt tgtaacagaa 31980 tgatttatat tccttttggt atatacccag taatgggatt gctggggcaa atggtatttc 32040 tttctttagg tctttgagga attgctacac agttttccac aatggaaagc ctttagttct 32100 aatccatgtc ttggcataga gtttcttttc tttttttttt tttttttgag gtggagtttc 32160 gctcttgttg cccaggctgg agtggaatgg tgtgatctca gctcactgca acctccacct 32220 cctgggttta agtggttctc ctgcctcagg ctcctgagta gctggggtta caggcatgca 32280 ccaccatgcc tagctaattt tgtattttta gtagagacgg ggtttctcca tcttggtcag 32340 gctgatctcg aactcctgac ctcagataat ctgcctgcct cggcctccca aagtgctgag 32400 attgcaggcg tgagccaccg cacctggccg gcagacagtt tctttttttc tttttgagac 32460 agagtcttgc tctgtcgccc aggctggagt gcagtggtgc aatcttggct cactgaaacc 32520 tctgcctcct gggttcaagc gattctcctg cctcagcctc ccgagtagct ggcactacag 32580 gcgtgccacc acacccagct aattttttgt atttttttta gtagagacga ggtttcaccg 32640 tgttagccag gatggtcttg atctcctgac ctcatgatcc acctgcctcg gtctcccaaa 32700 gtgctgggat tacatacagt ttctttaagc aagccttctc ttttccttcc tcccagttct 32760 tggtactctt tcactttcat atatttgcaa atgtaaaatt gtgttttagg tgtatatttt 32820 taatccatgt ataccagtaa cttaaaaaaa aatttttttt tttttaaggg agagcataat 32880 ggagctcttg tgatacggtg ctcttagtgg aagtttggct atcaattcca tcacctgtat 32940 ttcacatatt ttattaatga agttcttaaa ttaaattctc atatttagcc aagtattcat 33000 ttggctggga ggtagaaagc ctactaacca actttttttc atgaacaata tttttaaagt 33060 ccaagatttt taatacctac attagggaaa ttctagaatt aaattcttac aatgtggact 33120 gcatatgagg cttttagtga cagggaattt gttgaaggct atctgtgggt tgtattttgg 33180 tataacattt cctaatttta tttgtggtat gttcatttga tatcatttgg taatacctga 33240 aaacaggaac tgattttact gtgttgcttt ttcatcattt ctagctgaaa tgcacagaga 33300 cctggagcct taacagtctg gttaaacacc tcttaggtaa acagctcctg aaagacaagt 33360 ctatccgctg tagcaattgg agtaaatttc ctctcactga ggaccagaaa ctgtatgcag 33420 ccactgatgc ttatgtacgt gcttaaagat ctttagaaat tgtgatgtgt tttaaaaaca 33480 ttattataaa tgactttaga aaaattttat tatagtagtg gcagaaactc taccaaaata 33540 ttttatatca atttggcatt gaaaaatgct taggaagaca tttagtgaaa ctattcattt 33600 tcgatattaa ttagcaagta ccaatcaaca gattgttcaa tgctagttta ttttcattgt 33660 catgaagcca aattaatgtc taatttgtat gttaaaaaat gtgaacttgc tgaaaacatg 33720 aaaggctaat aaatccaggc tgagcaagca taaatagtac tgatgatgga tttgatatat 33780 aaacaattca gaatgaaaat aattatagta cagtttctat tttaaaactg gccttatttc 33840 ttatatataa aatgtggtga aattttagaa aaattgcctc caaatttagc ttgttgctgc 33900 cattagatat atttttatat ttacatgttt gtatgtagtg aaatctgggc ttatctttat 33960 atatagcact attgtgtgtt ttttaagaaa tgtattttat tccacagtga atttgttttc 34020 tcctaactca tgctttcatt tgtagatgaa tattttattg tttctccttt gcatctatca 34080 aaggaatgga aactcctttg aattgtaacc agcaaacaat tcacttttgt tagggaaatt 34140 ggatgataat tttcctttaa aagataccgc caaacttgag actaacattc tcagctgatt 34200 taagtaggat ttctcttact agattgcatt ttgttagatt ccattttaag ttattttatt 34260 tggatattgt gtgtaatatt gagtgtgaaa aagtgaaaac aaacttttaa ggctcaggca 34320 cctttctcaa ttttcacaat tggtatgatt attaaatgag gacatattga tatttgtgtc 34380 acataatagg ttgaattcca tgtttgggtg ctttgtgaat cattctcttc gatttttctg 34440 aagatgggac ttactgtttt atttcggtga tctttagcat actttttaaa tttttctgtt 34500 tttttatagg ctggttttat tatttaccga aatttagaga ttttggatga tactgtgcaa 34560 aggtttgcta taaataaagg tatgttaaga tccataaata aaatgtgaat tcactctttt 34620 gtgaggttta tctccaaaaa aggcaatatt cacatatttg caaagcattt agtactataa 34680 cttcttgaat gtctgagcag tcctgacatt agggtgggat ccatcagggc ccaagatgag 34740 tgtttcatct ttgttacttg tggcaaagca gcccttactt cttttacttt gtagcattgc 34800 tatgtatttg gcttctagag ttggggcttt gtggctttct tattgcagtg acacaaccag 34860 ctttctccta gtctggagat tatacatcct tgctataagt atttaaaatg ctttctatat 34920 aatgctttaa aacatgtaag atggcttatc cccaagatgg tagctaataa acactaagtg 34980 ataaagtagg taaagatcta tttattcatt tattaaatat tgttggtcat tttacagtgc 35040 tttctaacat actgatttac atttctaatt ttcttctgtc atttttctcc aaaaataatg 35100 gtcatgtcat ccaacctcag tgctgttttt agaggtcttg ataagccagt gagagcagaa 35160 ggagccacgt agtagagtgg gtgagcccag gctttttgtt gcacagacca atgtgaatcc 35220 cagccatgtg acctgggatg tacctgtttc tccaaacatg gaatgtagat actagcataa 35280 tgtccgtttt accgttttat agaataattg tgaagactta aagggacaaa ctattcgaag 35340 catctgtatt gatataaagt tatcactatt ctcgtagctt ccttttggag attttaaatg 35400 attgtgtttg ttaagatgtt aattaaatta ggccattttg ctaaatgctc ttaaaaatat 35460 ggcatgactg cctcatataa aatgatatga tattctttat aattgtcgtt gagcctctgt 35520 gggtggcagg ccctccttta tatgttaagg tagaagagtc tttattctta cttctcctcc 35580 ctggagagcc acttcctatg aatgcctgct ggttctctgt agtcagaggt cttgtggctg 35640 taacttagag tcagtctcca tatccctggg ttctgcatct gtggattcaa ccaaccacag 35700 attgagaaca ttcaagccaa aaaaaaaaat tcacagtttt aaaaaaggaa aagttgaatt 35760 tcttgcatgg agtaccacat tgaatctata tgaatgaagt gatgcgtagg cattttataa 35820 ggtattataa gaaatccgga gatgatttaa agtatacagg acaatgtgta tagattatat 35880 gcaaatattg cagcatttta tataagagac ttgatcatct atggatttga tatcagtggg 35940 agggaggttc ctggaaccaa tccctcaagg atacagagga atgactgtat gttaattaac 36000 tgaggcaggt gatcggtttt ttaagctgat tagggaaaca gtatataaga acttacttaa 36060 ctcataataa aactaaaatt caacagggga gagttatgat tttttggctt tatggttgtg 36120 gaattgcatg taggttacat gtacaatttt gttacatgtg caattttgat gaaaatgctt 36180 ccaaggaatg tttatgatat ttttcactaa agtaacatat attaataaca cagtactgga 36240 agtcctggta tctgtgtact tgtcattgta atgctacatt atttgacctt cacttttttt 36300 cccctttatt acattatatg tgtgagtata ttgtgacatc ttgactcaga ttccagtgaa 36360 ttgtattagg ttggtgcaaa aataattgtg gttttggtaa tttttaatgg caaaaaccac 36420 aattactttt gcaccaacct aataactaag attaccatct ttttttcctt ccttcctccc 36480 ttccttcctt tctgttattc agccagaagt atcagcatca ctgttctctt attttcttca 36540 tgtacatatg gatgatattt tcgaatgacc acttttctct tttgcttttt attattagac 36600 tgtttttttc ttcttgttaa aggataaaaa gattagaaca taaaaggata tttacacatt 36660 gtttccccat tgacttattc ccaagatggt agctaaaaac accaaatgat atagtagtta 36720 aagatacatt gactcattta ttaaatattg ttgagcattt tacgatatgg gaataccgta 36780 gtgaacaagc caggcatact ctgtttcctg aggggcctac agttttattg gggatataga 36840 tgagtgaaga aagcaattgc agtgtaggga gatgagtctt atgtcatggg aaaacaaggt 36900 gctgtagttg acacaccgag aggcatctga cacattgggg gaaatattct agaatatttc 36960 ctggagaaag tgcaggtaaa agccagacct gaaacctgag caagagttag ctaaggccag 37020 gtgcagtggc tcacgcctgt aatcctagca ctttgggagg ccgaggtggg tggatcacct 37080 gaggtcagga gtttgagacc agcctggcca aaatggtgaa acaccatctc tactaaaaat 37140 acaaaaaatt agctgagtgt ggtgacgggc acctgtaatc ccagcttctt gggaggctga 37200 ggcaggagaa tcgctttaat ctgggaggtg gaggttgtag tgagctgaga ttgcaccatt 37260 gcactccagc ctgcacaaga gcgagactct gtctcagaaa aaaaaaaaaa aaaaagttag 37320 ctagctgaag agtataggaa agaatgggta caggaaatta caggtgccaa gttacagagg 37380 tgagagaaat tatggtatct ataggtaatt gaaagtaatt cagtatagtg aacattgaat 37440 agggctgggc ggatgaaggc aaagcagaaa aaggaaagca gatgggccat ggtaaggagt 37500 ttatatctcc tcccaagagc aatcgaagtg actgagagtt ttaaacacag cagtgaagtg 37560 aattacatta aaaaaataag aacttgggct ctagaataaa aaacggatat aggaggaagg 37620 caggagtcac agtaggaata tcttttggga ggctgtgaca ataatccaag tgagaagtaa 37680 tggcaacttg agtcggttaa ttgtgttgag aatggagaga agttgacagg ttcaaaattc 37740 atttttcttc tttttttgag tctcactctg tcacccaggc tggagtgcag tgatgcgatc 37800 ttggcttacc gcagcttcca cctcctgggt tcaagtgatt atcctgcctc agcctcctga 37860 gtaactggga ttacaggtgc ctgccaccac gcccagctaa tttttgtgtg tttagtggag 37920 atgtggtttc gccatgttgg ccaggctggt ctcgaactcc tggtctcaag tcttccgccc 37980 acctcagcct cccaaagtgc tagaattata ggcatgagct accacacctg acctcaaaat 38040 acatttaata gagcaagcat gagccactat gcccagcctc aaaatacatt taataaacca 38100 atggaatttg aggtaatgat gaaagacaca tgtcaaggat cattcctgtg ttgttggcat 38160 aagcaacagg gatgaaaagc attgaggaag agcaagattt tgggatgcgt tgtcacacag 38220 ttgattttag gtatgttaag ggagggagac ctgtaagaca gcaaagtgga ggtggtgcaa 38280 gaattagttg tgttggctgt agcacagagg acagtttgag ttaagagagt tgggactgag 38340 aatcccgagg aactcttagt gttgaacatt tgcgtggagg aggggacacc aaaggagttg 38400 ccatagacat cgaggaaatt aggaggtgtg gtgtgcagaa agccaagtga agaacatgtt 38460 ttaagtagga ggatgctatc aactgtttta aattctgctg agagtttgag aaactgagga 38520 cttagaattc atcattagat ttggcaatgc gccaatcatt tgtaatcttt taaacaatag 38580 ttttgctgta ctgggtagca aaagagtgat ttgaggagtg gtcatttgga gcatatgcta 38640 ttcaaacaga gaagagtcca cgggctttgg taacatgaag gtcctataac catagcaaga 38700 gaatgaggtg ggtggaagtc atattaacgt gaatagagga gtaggttaga tctgaggaat 38760 gtgggaacag agacagggtc tcattatgtt gcccagcctg gctcagactc gtggcctcaa 38820 gcgatcctcc tgcctcagcc tcctgaatac ctcgggtttc aggcctctgc atctggcttg 38880 aaaacaacat tttctcagaa gcttgtttta gttgttttag aaataacgaa ggcatgtgta 38940 aacaactgtt ctagaagctt agtttggaaa gggaacgttt attgatgcat ataacactta 39000 tatgttgggt gcttatgtgt caggcactgt tagagttgct cgggaaaatt tacaaaccaa 39060 gcaaaccatg ccccttcatt tcctttgggt gaagtgaggg agccatgtgg ttatctgaag 39120 gaagagctta gcaggattag agggaagaaa gtgcaaagcc tcctagggtg attggctggc 39180 tcttttggag gaacagtacc tataactgaa tgaaatgagt gagggtaaga gtggcaggaa 39240 atgaggctag aaaaggagct tgggccatat cacgtagggc ctcgtaggct gtgaatctga 39300 cttcatttct tattaatgaa aataaatacg atgatgggtg atgggaaacc catagaggat 39360 ttggagcaga agaatgatat aattaaaatt ttattttaga aatatttttc tggttgtcgt 39420 aagaggaaaa atatttagcc ccagggcatt ttggcagaga gttaggaggc tattgtaaca 39480 gcccaagcaa tagacaataa ttgtttggat taggcgggta gcaatagagg tgatgagaag 39540 tcgtagcttc tgtaggtatt tggaagatat atattgtgaa ggatttgctg atgaattccc 39600 tgtaaggggt gagatgtaaa gattcataga acattaagat attttggtca gatcatctga 39660 tcaatggaaa ggtcagttat agtggacaga ttatgagaag aacaggtttg ggtgagaaaa 39720 ctttagattt cagtgttgga tatcctaagt tttagatgat tattgatatc caagagatat 39780 caatatttgg gatcaatttg ggaaatatga tcccaaagtt caaggttgag gttggagatg 39840 taattcagat ccgatggtag ttaaagcagt gagactgaat gagataaaat agggagtgaa 39900 tgaaataaag agtaggtgtg atattgacct caagggcaca ccagcattta gaggttggga 39960 agatgaggag agagcagcaa agaggactgg gagggccact aatgaaggag ggaagtacag 40020 gaggtgttta gttctgaagc cacctgaaga aaatgtttgg aataggaaga agttgtcagt 40080 tgctttaaat cattcgggga ggttgagtga gatgagagtc tagaactaac agttaggttt 40140 gatggtgtgg aggccatcag taaccttttc tttctttttt ttttttgaga cagagtcttg 40200 ctcagtcacc caggctggag tgcagtggcg cgatctctgc tcactgcaag ctccgcctcc 40260 caggttcaca ctattctcct gcctcagcct ccggagtagc tgggactacg ggtgcccgcc 40320 accatgcccg gctaattttt tttttttttt gtatttttag tagagacggg gtttcaccat 40380 gttagccagg ttggtctcga tctcctgacc tcgtgatcca cccgcctcgg cctcccaaag 40440 tgctgggatt acaggtgtga gccaccgcgc ccggcccaag agtaaccttt tcaaaagcag 40500 ctttgctcta ctgatttggg taaaagctta gttgcagttg gtttgggagg aaatgggagc 40560 agaaaatttg agagagtgag tgtagacaac tctttcaagg aatttcgcta taaatgggag 40620 tagagatctg aagactgaat aattagcaaa ctgaaaagtg ggaagacgta attctcttat 40680 tatttcattt ttcttagtga aataagaggt gaagttctct gagtaatagg agggtcaaac 40740 aggtgttaga agttcacaaa gaaaggaaga ggtttgaaat agtcattttg agagtgggaa 40800 atgtagaaga attaacagtc attgctgagg gtgcgtttga aatctgtcat gagtttaaaa 40860 taacttgtgt catcatcgat gtgtttattt tcaactatat tcaactgctt gggtgtaggc 40920 atcaggtagg taaaaaaagt gggttttatt atgagtagag gttttgccac gtaattacca 40980 tggagggagg gaagagcaaa ggagttgaga gtatagatac aaaggaatga ttactgtaat 41040 gtgggtaaga gaggaatgga aggctcagtg ggcagtggga gtagggatgt tgataggtaa 41100 ggaaaaggtg ataggatcaa tgcatttggt tctgcaagtg tcaaagtatt gttggggaaa 41160 gcatgctgga aggaaagata gggatgctgg tgttctcagg gtggaaggct tacagttgta 41220 gtctggaagt ggtgatttta ttggcaatta taaggtcaac ggtatgacta tggaattgag 41280 tggctaaggt ctgttgaaga aaagattgtc ggaaatgcag gggtcaagga actggcctgt 41340 ggatgttgaa ctcactggca gtgatcaagg aatagtagtg gagtgaaagt agttaatgaa 41400 tcaggcacta agatctccaa gggatgaaag gatgcagttt ggagatgaca agataactgt 41460 agtaatcagg aatagcaggt tttgtagctc tgtctcatag gcctcagagg agatgggctt 41520 ttgaaggaca agagaaatga tgatgaataa attctaagca ggggaagtgt ttgggaaagc 41580 agggcaggct ttgtgctgtt gatggcaaat gatgtaccag acaggatgaa gttgagaatt 41640 tggaagttga tcactgatta gaaaggctta cattttattt tggccggggg tggcagctca 41700 tgcctgtaat cccagcactt tgggaggcca aggtgggcgg atcccttagg ccagaagttg 41760 gagaccagcc tggccaccat tgcgaaacac tgtctctact agaaatacaa aaaaaaaaaa 41820 aattagctgg tcgtggtggc acatgcctgt agtcccagct actccggggg ctagggaatg 41880 agaatagctt gaagccggga ggtggaggtt gcagtgagcc gagattgcgc cactgcattc 41940 cagcctgggt gacagagtga gactctgtct caaaaaaaaa aaaaaggaag ggcttacatt 42000 ttattttggt gctgactggg aatgaaggca atgagggatg actgttggag aaggctgtgc 42060 ttactaaaca gtattattaa gtagcagcat acatggtgtt atactgactt ctgattttgc 42120 aatagtacag acaggttcag attctcattt ccaccttctc cttctgccta ggtgaataac 42180 tgctgggtta tagtacagat gactgcagat catttggaat ttactttaaa tgtaaacagt 42240 aaaaatttga aagagaggga aagtgattga ggcaatttgg ggattgaata agaaggtctt 42300 tttgttggaa ttcatttaag gaaagaaaat gaaaatttga tccctaatat tatttaatga 42360 agtggctaaa tgaatatctc tgctttgtgg tttgaaaatt aatattgatt ttttttcccc 42420 ctagaggaag aaatcctact tagcgacatg aacaaacagt tgacttcaat ctctgaggaa 42480 gtgatggatc tggctaagca tcttcctcat gctttcagta aattggaaaa cccacggagg 42540 ttaaatatta cctttttttt ttttaactta aatcaattct gtttattttt ttatcacatt 42600 ttcctatatg tgaagaatac tattcattaa ggctgactca tagaaatttg cttgaataca 42660 cacacacaga ctgatgcata aatttgagaa atatctttcc agttgttgaa tagtgaatcc 42720 aaaggtttaa gccttttctg tctgctttgt aggatgtttt atgaaacaaa ggaatagaaa 42780 ttgtattcat attatacatt ttgaaattat atctatatta tattttttgt caaagcaaaa 42840 taaattatac attaaggaaa atatttaaga ttcaaagttg tcattttctt tctgttaatg 42900 agtatctttg atttaataac atttatagtt tggtcacttg aaatctatag tgaccaaaag 42960 caatgtcata tttagtagcc tcatttctgt tactatctga ttattactta agaattctac 43020 ttaattaata gattattaga acaaaaggca ttccaatttt agagattctt ttatggttaa 43080 agcactaggt aacttaaaaa atttggatca aatgttatac agattaatag accttggaat 43140 acaggggcta tgtctttttg gaatcagacc ttgtcctggc cttaattgca ggatgacttc 43200 cttattaaat ctctaaaagc aggaatgctc tggaacaatg aacaattaga atgtggtaat 43260 gtaattttgg gccaaaaaat actttgtaga aatgtgattc tcttacttgg aatagaaaga 43320 attctgactc gaaaaagtgc agttaatgta tgcttttctg ggtaagattt gtgatagatt 43380 ttgattgaga tttaaaacca tgatatataa atttagcttt tttgtcaaag taatttgcca 43440 ccctagaatt tgtgttggta atttttaatg caacttggac aatttctgaa agatgtaact 43500 ttcttttttt tgagacgagt ctcgctttgt tgcccaggct ggagtgcagt gacatgatct 43560 caggtcactg caagctccgc ctcccgggtt cacaccatta tcctgcctca gcctcccgag 43620 tagctgggac taccggcgcc cgccacccca cctggctaat ttttttttta tttttagtag 43680 agacggggtt tcaccgtgtt agccaggatc gtctcgatct ccggacctcg tgatctgccc 43740 gcctcagcct cccaaagtgc tgggattaca ggcgttagcc accgcgccca gcctgaaaga 43800 tgaactttaa aatggggaag gatactagta aagccatttc ttactcatgt atacattttt 43860 ccctccatga aattagagca gccacctttt acatgacttt tacatgcatt tcagattttt 43920 gtactagcaa ttaaaatatc tactggatgt aaatcacatg tgcttaatgc tttgcttcat 43980 aatatctgtt gaagtcaatt aaaatataga gacagatctt taaattgaac atgttttatt 44040 tgggaagcaa gaattaaatt tgaggcatat acacagactg ggtgtccttg gtatctctga 44100 agaacaaaga gaagtttgga ggttatagaa aaaggaaaat gtgacattgt ttttccagaa 44160 agttctttgg cactagtaaa ttttggggag ttggaagctc tgatgggtta gtgactgtgg 44220 tgggtaaaac tagtcttaga gtcacaacag gttgtttcag tatctattag ataaaacagg 44280 ttttaggtta caataggcag tttcagcagc taggcttgca gaaaattaca ttcttagagt 44340 aatgttatgt gccttgagtg cttttttccc cttggccctt gactctgatt tagttgggta 44400 tgacaagaat tatcaattta tataattact ttttacatat tgaagctgaa taggttttct 44460 taaaacttgg aaatgggaaa tactgggtct tgtgaagttt tagtgtgaaa acgataacta 44520 gtctcttatt tcatgctctt tgtaacaagt ctacagtaat acctaatgta tctagatgac 44580 acctcagaac caggagggaa caaaaaagac ctctgagcag tcaaaataat gctataagca 44640 tgtattccag cttactttcg gcatttctgt ggagtgcagg aggccacatt ttgttcatag 44700 atccagtttg acaagcttgg gtactgagtt aaagtgaaaa tggtgtaaat aagtaatcat 44760 attcacatga cagtaggtgg aagtgacagc tgacaatctg aaagagtgga caaaactata 44820 aaaattagaa ctaagaactc ttaaaataga acggtttgaa gtttgttaca gaagggagca 44880 gctttatgct tcagtggact ctgaaggtat tggcagtgta tagtactgct tagtcattga 44940 tttaaattcg gtatatatct cttctattgc tgtcatgtac ttgacattct gctgggtgct 45000 aaggctgtct gcaggctact aatatgcata ataacaatcc tgaaaaagaa ggaaaagtat 45060 actgtgcctt actgaagaag gcaggacagc cgttggtatt tgttagagta aatattagtt 45120 atcttacata aagcatgtta tattccctga tgtcagggcc tgataaatga gcccttacac 45180 tcttgatagt caatctgtgc cactgttgct gtgtttgtat gttacaccat ttcctgtcca 45240 tgtaacagtt aaactgtatc acatatctgt tcctactaaa ctatttgcat ataattttaa 45300 catttgagtg gctgtatata aagctaaaag ttctttataa gatttatagc atcttagaat 45360 gtttaaatta gataacatta gtgtgctttt agtttttgaa tttaattttg ctcttgattt 45420 tgtttgtgtt aatgtagact ttgtctacgt aagcttgagc ccaactttgg agtggtgttt 45480 tcagtgatgg aagtaactgg aaataactca tgaaaccact tagtactttt gatagtttat 45540 tcccatgaag gatcaaattt ttacttgagt cattaatata aaaatttaaa agacatgtca 45600 gattttatta agcatggatt ttaaatatat aaatattaga agacctaaac aaaatcgcta 45660 atgaaagagt aaaacatgtc cctgcctatc atactccctt cactttcact gatttctgct 45720 tttatgaagt actttaataa gctctacaac aaataaacaa gacattgtgc ctcattttac 45780 actctagcag tggttttcca ttccaactaa ctagattggg tttataatat agtcatttaa 45840 acttacttag ttaaaatgtt atacattagc aactgcaatt aaggagctaa gaaattcagc 45900 tcgtatttat ttatatgcat cttatccata gtttctcact tgttatattt gcctactgat 45960 ggcaaattga ttttttctgt tccaaaaatg tagtgttttg agatttttgg agatgcaaaa 46020 cagcatcatt ttcaaattag atcacaaaca atcttacttg ttgcagttga gactagtaat 46080 tgatcagtga ggtgaaaaaa ttaggcaaaa cggtatcatc aaaattttct ttcttttttt 46140 ttttgaaaca gagtattgct cttgtcgccc aggctggagt gcaatggcac gatctcagct 46200 cagctcactg gggcccctac ctacgggatt caagggattc tcctgcctca gcctcctgag 46260 tagctgagat tacaggcgca tgccaccaag cccagctaat ttttgtattt ttagtagaga 46320 cagggttttg ccatgttggc caggctggtc tggaacttca gacctcaagt gattcacctg 46380 cctcagcctc ccaaagtgct gggattacag gcatgaacca ccgtgcccgc cccaaatttt 46440 cttttaactt aaagtgttaa tgtttgtttg ttcccaatat ttttatatat gtcaaggctt 46500 tttcattata tacaggccag ctctttggag ttctgcatag tgtttcttgt ttaaaccaca 46560 cctataatgt accatctaca atttccaatt ctttaagaca gagtgaaaaa ttaagacacc 46620 tgaagcaatc tgagtgcgga gtcctaggca ttatgatttt ccttgacact tttagggttc 46680 ttttatcaca gtttatcaaa cacctttttt tttttaacaa aaaacaaatt tacaaaatct 46740 ttccatgtat tcaacttaga atttaatgaa atagggtttt tttttttttg gtggtcatgt 46800 atcatcaact ttctttacat ttaattaaat taatcaacaa aaaacatata gttgacataa 46860 acaaatttgg gaccaagcac tactgactct tagtaaacat acaagtcaac tgttggtgca 46920 gaagtgcctt gatgctagag agtagcctgc aagctgtaat tatatatggg cattagggaa 46980 tgaagaacag ccttaatact attgatcttt taagtgaagg tcagcttaga aagcttttac 47040 ttgttaaaaa gcttcacagt ttgtccttgt agttaatgca attgaagttg aattaatctt 47100 tcttaatttt ttttttaggg tttctatctt actaaaggat atttcagaaa atctatattc 47160 actgaggagg atgataattg ggtctactaa cattgagact gaactgaggc ccagcaataa 47220 tttaaactta ttatcctttg aagattcaac tactggggga gtacaacaga aacaaattag 47280 agaacatgaa gttttaattc acgttgaaga tgaaacatgg gacccaacac ttgatcattt 47340 agctaaacat gatggagaag atgtacttgg aaataaagtg gaacgaaaag aagatggatt 47400 tgaagatgga gtagaagaca acaaattgaa agagaatatg gaaagagctt gtttgatgtc 47460 gttagatatt acagaacatg aactccaaat tttggaacag cagtctcagg aagaatatct 47520 tagtgatatt gcttataaat ctactgaggt actaaataaa gaggaagcac atttttagtt 47580 attagtaggt tctggcagac tttattcccg taaagagaca gatagtaaat attttaggct 47640 ttgtgggaca tacagtctct gttgcagtaa ctcagttctg ttattgtagt gtgaaagcag 47700 ccacagacaa atgtaaacaa atgtgcctgt ctttcaataa aactttatct acaaatacag 47760 atagtgggcc acatttggct tgcgagctgt agtttgctgt tcctgactta gtatgatatg 47820 cagcattgtg tagtggaaag attttatagt atcaacagac atttgtagga gtttgctatt 47880 ttataatttc gtatgctttt ttcataatag atgtctctgc tttttgtgga ttctcttcat 47940 atctactagt gtttactctt ctgactttga tttttggggg tgtattttat ttctttatac 48000 agaatttttt tcttttttct ttcttttttt gagacaaggt tttgctgtgt caccccagct 48060 ggagtgcagt ggtgggatct tggccccctg cggtcttcaa ctcctgggct taagcgatcc 48120 tgtcacctca gcctccctag tagctgggac cacaggcctg caccactaca ctcagctaat 48180 ttttgtattt tttgtagaga tggggtttcg ctctgttgcc cagactggtc tccaactcct 48240 ggactcaagt gatccacctg ccttggcctc ccaaagtgtt ggaattatag gtgtgagtca 48300 ctgtgcctgg cccagaattt ctttacttgc tcatgtgaga gagtttctaa taaactcctg 48360 atgcttttgc ttgacactat agttttactg tcatctcaga gtcagatttt ttccttaatt 48420 tcttcattaa attgatttct taatttctca tttgttttgc attagtttac aaaattactt 48480 aagatgccta tattctctga aattttatat tttatttcac gataaataag tttaaaaaat 48540 tagatttgac catttaatta gagttatttc cccatcattt ttctaatggc aacaataatt 48600 ttagcatttg agcaattctc tgtattttgg taactattag taatcacttt tatcagtata 48660 aacatgcatt tcattttaaa atggttttca aaatattctc ataccaacca ttcataaaag 48720 atgttcccct tctgggaaat atcagttttt gctaacatct gcatttccct ttgattttct 48780 aggaatttct tattaggtat acactttaag tgatatgttt catataatat tataggatta 48840 tcaggatttc atgatttttt ttttttgaga tggaatctat ctctgtcgcc caagctggag 48900 tgccgtggcg cagtcttggc tcactacaac ctctgcctcc ccggttcaag tgattctcct 48960 acctcagcct cccgagtcac tgggattaca ggtgcccgcc accacacccg gctaattttt 49020 gtatttttag tagagaaagt gctgggatta caggtgtgag ccactgcacc tggccttgga 49080 tttcgtgatt tgactgacat cttttacacc aattattgcc atttttttat tgggtactaa 49140 ttattagtat tgctttcttt attcgttaaa taagaagtaa aagaactttt aaaaaataaa 49200 ataacttttt ttcctagtac aaagcttatt ttcaattttt tttattgctt aaattttgca 49260 ggttaattaa ggctgtactt ctttttccta cttcctgttt aaatatttgg cattttttga 49320 gggttttctt tctatggatt tttgtggggg atcccatctc gttggacact tggttcctgg 49380 agattgccaa attattgaaa agtttcctca tacccaaaca ttggcaatag actgaataaa 49440 taacatctct gacattattt ttcaattata tagagaatgc tttttgtaaa atactgattt 49500 atttaaagat attacaatca tagtagtttt ttgcaatctt ttttaaatca gtggatgtca 49560 aggaacaact attgttcttt gtacggcatt tttcaacatt gtgaagagtt cttatactca 49620 aaaagtttgg gagacacagt gtgacattgt ttaacctgag ttgaacttgt cattttgtat 49680 tcttgtttag agcagggatt ttattttgtc tctttatcta actttgtatt cctaactatt 49740 tctttctttc tctttggttc tttgtttctt tgttcattct tctctctctc ccttttttat 49800 ctatcatata aatatgtaaa tatatattat atatccatta gggaagagga agttgtctaa 49860 agatatctag tatataggag ctttgttctg cagaaaagag gatatgaagt caattatatt 49920 ggaaattaat gcttaatact ttttttaaag catttatctc ccaatgataa tgaaaacgat 49980 acgtcctatg taattgagag tgatgaagat ttagaaatgg agatgcttaa ggtatgttta 50040 caattataaa aatattactt caagttcttt ccaaaggaca tttaattaag taaaatatta 50100 actaattcta aactaggttc taccacaatg aaattgctac taattatgta acattagatt 50160 tcacattttc caattcatgt ttctttcatg tagtctataa ataatgggtt agaggtaatt 50220 tactaatttt aaatgtgctt tccttgttcc ttcttatttt ttattttgaa gacagggtct 50280 cactctatca cccaggctgg agtgcagttg ctccatctcg gctcactgca accttcacct 50340 cctgggctca agtgatcctc ctgcataagc ctcccgagta gctgggatta tgggcgtgca 50400 ccaccatgcc cggctaattt ttatagtttt agtagagaca gggtctcacc atgttgtcct 50460 tgctggtctc gaactcttta cctcaagtaa tccacccgcc ttggcctccc aaagtgctgg 50520 gattacaggt gtgagccacc acacctggcc ttggatttca tgatttgact gacatctttt 50580 acacaaatta ttgccatttt tttattgggt accaattatt agtattgttt tctttattcg 50640 ttaaataaga agtaaaataa ctttttttta aaaaaagaac ttttttccta gtaaaaagct 50700 tattttcaat ttttttattg cttaaatttt gcaggttaat taaggctgtg cttccttttc 50760 ctactttctg tttaaatgtt tggcattttt tgagggtttt ctttctatgg atttttgtgg 50820 gggatcccat cttgttggac acttggttcc tggagattgc caaattattg aaaagtttcc 50880 tcatacccaa acattggcag tagactgaat aaataacatc tctgacacta tttttcaatt 50940 atatagagaa tgctatttgt aaaatactga tttatttaaa gatattacag tcagtagttt 51000 tttgcaatct ttttaaaatc agtggatgtc aaaaacagct attgttcttt gtacagcatt 51060 tttcaacatt gtgaagagtt cttatactca aaaagtttgg gagacacagt ttgatattgt 51120 ttaacctgag ttgaacttgt cattttgtat tcttgtttag agcagggatt ttattttgtc 51180 tctttatcta actttgtatt cctatttctt tctttctctt tggttctttg tttctttgtt 51240 cattcttctc tctctccctt ttttatctat catataaata tgtaaatata tattatatat 51300 ccattaggga agaggaagct gtctaaagat atctagtata taggagcttt gttctgcaga 51360 aaagaggata tgaagtcaat tatattggaa attaatgctt aatacttttt tttaaagcat 51420 ttatctccca atgataatga aaacgatacg tcctatgtaa ttgagagtga tgaagattta 51480 gaaatggaga tgcttaaggt atgtttacaa ttataaaaac attacttcaa gttctttcca 51540 aaggacattt aattaagtaa aatattaact aattctaaac caggttccac cacaatgaaa 51600 ttgctactaa ttatgtaaca ttagatttca cattttccaa ttcatgtttc ttttatgtag 51660 tctatgaata atgggttaga ggtaatatac taattttaat tgtgctttct ttgttccttc 51720 tttttttttt ttttattttg agacagggtc tcactctgtc acccaggctg gggtgtagtg 51780 gtgccatctt ggctcactgc aaccttcacc tccagggctg aagtgattct cctgcatgag 51840 cctcctgagt agctgggatt acaggcgtgt gccaccatac ccggcttatt tttgtatttt 51900 ttgtagagat ggggtttcac catgttgccc aggatggtct taaactcctg ggctcaagtg 51960 atctactggc ctcagcctcc cagcgtgctg gggattgcag gtgtgagccg ccgcatccag 52020 ccctgtgttc cttcttgtgt tactttcttg taattttttc ctggaatatg ggtagtgatt 52080 tggctctcca gtattgaaat tgagtttcct ttcttccaat tcatgtgtat ccatttttat 52140 ttggaagttt tgtttttata cattcaataa tcatctttac tttctttggt attatttact 52200 atggatattt tatattatat aattttcaaa tggattaaat ggttcagttt tactcttatt 52260 attgagattg aaaatactag tttataattt atatattttc tattccttta cctctaattt 52320 ctttgtcagg tgttactaac caaagatgta taataagaaa agccaatgta gctaaattaa 52380 gtaaaaaatg aagaaaaaca cagaagttcc ccattatgca tttttttatt cctaatcttt 52440 aggttgatga gattttttta tttttatgaa atgagattaa tttattgact tttttagttt 52500 tgaggccaag taatgagtag tgagtaagaa tgtatattct agggccaggc atggtggctc 52560 actcatgtaa tctcagcact ttgggaggcc gaggcaggag gatcacttca ttccaggagt 52620 ttgagaccaa cctgggcaac atggcaaaac cctctctctc cagaaaaata caagaattgg 52680 ctgggtgtgg tggcatgtgc ctttagtccc agctacttgg gaggctgagg tgggaggatc 52740 acctggggag cctggggagg ttgaggctgc agttagccat gaccatgcca ctgcactcta 52800 gcctgggtga cagagtgaga ccctgtctca attaaaaaat taaaaaaaaa aaagtagatt 52860 gtgaattcag atgtaggttt gtatcccagc ttttccagtt agtatctgtg tgactttggg 52920 gaagtttctt agcatctttg atactcggtt aacagttgta attattattt aaggtattgc 52980 ttgagaagag cttagtatag agcctgacat ttagtaagtg tttaatacat attagctaac 53040 agtaaaacta gaacataaat actgaattgt attttgttat taattatcca tttctctgag 53100 aagtactgtt ccaatagtac atttatagga aacttgtgga cgtctacaaa cgtatacatt 53160 aaatctctta gaaggcaacc tggatgccca tattagagaa ctctatttta aacatgcatt 53220 ctaagtatgt ttgtggactt gaataaaata aaacaaacag aaacacttct ttcttctgcc 53280 ttcaggcttg aaatgaacat actttttttt aaaaaaaaac cttcaaaatg aaaatattaa 53340 ataaaagatt taataaaaag agaaagtaaa aactgtagtt taataaagtc ttcctgtctc 53400 ttcatagtta aaaaatgtta tagatgaaac aattttgaaa tattcttgaa atagataatc 53460 tttatttagg ggagaatgtc agatactgtc aagccaaaat aaaaacaaat aactttattt 53520 catgtttgta aaattccttt tctaaaatga tttgaatctt ttgttgtttt gacaattcca 53580 aaacacattt attgtttgct catagtttca gccttattca gaaagaatgc gactgacaca 53640 tgatatagag aaacttgttc caaaaataac attaaaatcc acgtttacta cttgagaatc 53700 gaaaatattg aggtgcaata aagaataaaa tgttttaaat tatccaaatt taaaatttat 53760 gatagctttc cccaggggca gtttattata tgctattaat gagccttgtt tatgctggaa 53820 atgttccatc tttggccttg cgccttagaa accattcatg agcacatatt taaaccggag 53880 cacacatgtt cttttgtagt atggcttgca catctgccag ctttcgacaa aattgtaggc 53940 cctgttaata atagtccttt tgtgtttggt gaaaaagata cgacactgtc agtggttttg 54000 cttttaagat ttcttttaaa ctttcagtct ttagaaaacc tcaatagtgg cacggtagaa 54060 ccaactcatt ctaaatgctt aaaaatggaa agaaatctgg gtcttcctac taaagaagaa 54120 gaagaagatg atgaaaatga agctaatgaa ggggaagaag atgatgataa gggtaagcac 54180 tgaagtatgt ttgaaatgac tcacctgtga tacctaccac tgactttaac ttaggatcca 54240 gttttggatg gtttggaggt cagggacttt gtggcatata gttaattatt ggatccttat 54300 aagcttttgt ctccttagtg cttttgtctc cataaagcac aatcttacta cttagaaaaa 54360 tagagtaata gcattatgat gataaaaata tctttccctt tgtttttttg tatttctcca 54420 aatcattata gctctcattt agaattatta aagctgagaa ctctaacaat gaacttttat 54480 tgtttagtgg ttaattatct tgattctttg ttttgccctt tcttggccac tcaggaatct 54540 ttcaagctca ctgtggacag ggaaagtgac ttgggtagag ctaacataac ttcattgtgc 54600 tgtgcagtta gaattttgac caaagatgtg ggtaactaac ttttcctaac taaatgacat 54660 ttaggtaact aaactaaacg agattttcgt aactaaattt tggtgtaact acatttagct 54720 ttaggtaact aaaacgaaga ttttatttta tctgtggatt tttttagtgc gggactaatg 54780 taatttctga ttaccattaa ttgaaggttg gttatattat aacatttgga ttggtatatt 54840 gcttgccatg gtttgttcta aatgttagcc tttagaagta ttcctgattc taaaacatca 54900 gtttttttta atagtcctgg caaagtgtga atcacaacaa aattctaata cttaaaagta 54960 atccaagtgt cacagatggt acccagaaga ccagtttgta ttggaattaa aaaatagaaa 55020 acattaaccc atggtagctg tcactgtatt ctttcaaaga agccaatgaa ataaactgtt 55080 ttctccctct atgtggtgtt tttctacttg aacataaatg cacattttat tttatttcca 55140 gactttttgt ggccagcacc caatgaagag caagttactt gcctcaagat gtactttggc 55200 cattccagtt ttaaaccgtg agtataatct catttaatca aatcacatat ttagtattct 55260 ctttaaaaca agggaaaagg caaataacct gtctgcttaa cagcaacagc acaacttcac 55320 tatagttata catgccacac tgtattttct gtgtgactac aaaattattt caaagtgata 55380 tttatataaa attcatttct gcaaattgtt tttataagtg aggaaaaatg gttttccttt 55440 aactgagcag ttctgagtag aaactagttt aaagatactt ataaataaat gttaatttaa 55500 tactgacttg tttttcatta aacgagtgtc tatgtgcctg ttttgtgtat attacccaga 55560 acatgcagat gtactagaag ttcttaatac aacaatttga ggaatagtga taatcttatc 55620 tattttaatg tactcaaaat ttgtttacat ctaacaggca catttttgtg aggattaaat 55680 gagatgaata agaatgagat gaacaagtaa atgtgaataa aactaataag cctgtgaaaa 55740 tctagactgg atttttccta ttctgagaat ttaaaatata atccactgaa gtatttcttt 55800 ccttttttct tttgatctta aacatttttt atttatgtct tacatacaga aaagtgcaca 55860 tgttgtagag atcaatgaat tgtcataaac tgggcaccct gtggccagca cttagttaag 55920 aataggtcag taacagcatg ccagaagacc acctctccaa ttgatttttc ccatgatatt 55980 ttattaagaa aattttctaa gatgtagtaa agttgaaaga acttttttct gtgcatgtct 56040 gtattcccac cacctaaatt caactatcat tactatactt gctttatcac atatccatcc 56100 attcatatgt ctctatccat ccattcattc attccagttt taaaatgcat ctcagggtca 56160 atcgaggaca ccattacact tccacctaag tatttcagca tgtaaattat taacgagtta 56220 aatatttact taacagtttt ttctttggtg taaaatttgc acgtaaggaa atataaaact 56280 ttaagtgtac atttgcaaat tttaaatata catgtgcata cccatgtaac ccaaattctt 56340 atcaagagat attattatca tcaccacaca gagttccctt atttcccttt tcagtcagtc 56400 cttgtccctg agcatttctc ttattatttt aaagtattga ttcttttgga tatctagtat 56460 gaagcttaga atctgttttt tactttagat gtatgtagtg aaatttaata tatataccaa 56520 atggtagttg ttagttagct tgaatgggac attggtcaaa tggcattgtt tgttttaaag 56580 ttccaggttt gtgcatttat gtatgaagtt tgaaaataaa ttctatgaga ggaaatgaaa 56640 aattgaatgg attttaattt gtaccttggg tttcttatta ataaaacaaa atagcttttt 56700 gcttttcacc ttcaagagtt cagtggaaag tgattcattc agtattagaa gaaagaagag 56760 ataatgttgc tgtcatggca actggtaagt tgtacttaag caaaacctaa tcctttaaaa 56820 aaataaaaca taaagagttt gaaatgctta atctttcatt aaactctcaa aatacaaatg 56880 caactacaaa tgatgtaaac tatagaagag agtgaacaaa gaacagatgc tcagatttat 56940 gtatcaatta gcttttagga agatagcata ctagtattga ccattcatct gtataagtac 57000 attgtaaaaa gaaatgaaag catcaaaggt ttatttttat ttctatattt ttttcatttt 57060 atttttatat ttttttcatt tcaaggatat ggaaagagtt tgtgcttcca gtatccacct 57120 gtttatgtag gcaagattgg ccttgttatc tctcccctta tttctctgat ggaagaccaa 57180 gtgctacagc ttaagtaagt catgttatca ttgccacaat atcaccctct ttttttcttc 57240 tgtgggtgaa acatctgatc catcatgcat gttaaaatct agttcacaat aacacatttc 57300 tgcaggtatt gctttatctt tattggtaat aaatgaccct ttagtggaag agcttacctt 57360 ctttcttgtg ttctctgtaa ttcaaagcta ccaggtggcc ctgataaaat ttttttaaaa 57420 aacattatta ctttatgctg gtttacattg aatatctcaa aattcttttc tctttttgtt 57480 acccttgctt tttagcttga taagaagtgt atacatggaa gtatattttt tatctatgaa 57540 acacttttca gcttcttcaa cctgagcttg caatctgttt taaattgata cataatatct 57600 ttacatattc atggggtact gtagtatttt gatacactca tatcaaatac acttgatcaa 57660 atcagggcat ttgttcatca acttgaacat ttatcatttc tttgtgctgg gaacatttct 57720 aatcttttct ttgagttatt ttgaaataca cagtgttgtt gttaactata gttaccctac 57780 tgttggttaa tgagtacaaa catacagtta gaaggaatag gttctagcaa cctattcctt 57840 taccccctgt catcccctgc tgccctgagc ttgcagtctc tttcaaagac ccaccttaaa 57900 aacttgcatt ctgataaggc ccttgaagga atttgcttat caagttagta agtgacaaaa 57960 aagaaaattg caaagaacag gaatataaat tattatattt ctttattctt tctcacttaa 58020 gagtgaaatt gatatgtgta atgtgtacat ggtgccagaa tatttgtttt tcttcttata 58080 gaatgtccaa catcccagct tgcttccttg gatcagcaca gtcagaaaat gttctaacag 58140 atattaaatt gtgagtaatt tttttccctc aacttttatt ttggatttat gggggtgcat 58200 atgcaagttt gttacgtggg tgaattacat gttgctgagg aagttgtgag taatttatgt 58260 catttctaat catgtggtca gatgtctgtg gtatatgaga gaattttgta tacaaacaaa 58320 ttttactaaa tgcatgaaaa aaaaagtcca tgattttaaa atgcactttc ttttgtacct 58380 ttgcaggact gttacttttt aaatccttca aacttgaaga aatctgttat tctcggttct 58440 tgggctataa gattagcatt gtactcatag aattataaaa attttggttt tggaagagaa 58500 gttggagaat ataaagattt gtctcatttt atagatgaga aaactgaggc tcagagacaa 58560 gtaatttgcc caaaatcaca caatgactgg ctgagcaggg actggattct aggtctcttg 58620 cccaaccaat tctatcatga tgtaattcct aaggagaatg tcatctcaga tacacataca 58680 cacacccatt ttgtgtgtgt gtgtgtgtgt gtatatgtac acacacacac aaacatatgt 58740 acacttatat atacatacac acacatatat taatatatat gcatatatat gcatgttcta 58800 attcagaaca ttttcatcac tcccaaaaga acacccctgc ccattaagca gttgctttct 58860 ttacgtatat attagtatat acatacacac gagatacaca tatatttact gagttttgat 58920 aaatgcatac aaagatgtaa accaaacctc taacaagata cagaatatca ctgacactct 58980 agaaagtttc ttcatgtccc tccccagtct gtccttccat cctccatcct aggcaagcca 59040 ctgctccgat tttctctacc atagtttggt agaatgccat ataaatgcag tcacacaata 59100 ttaactcttt tgtgtaagac ttctttcatt tgctgtaatg tttctgagat tctttcatgc 59160 tgttgcatgt atcagtagtt ttttgttttg ttttgttttg tttttgtttt ttcagagtca 59220 gggtctcctt ctgtcaccca ggctagagta cagtggcgca atcatagctt actgcagcct 59280 ctaactactg ggctcaagct atcctcctgc ctctcaagta ggctaggctg caggtatgtt 59340 ccaccatgcc tggctaatta ttaaattttt tgtagagaca ggatcttgct tggttgccca 59400 ggctggtctt gaactcctgg cgtcaggatt gtttccagtt ttggattatt acaaataaag 59460 ctgagacaca tataagtctt tgtatggaca tatggtttca ttttattgat acatgtcaag 59520 gagtgggatg actggatcgt gtggtggata tatgtttaac tttctttttt ctgagataaa 59580 attagaaggc gatcctcctg ccttggcttt ccaaagtgcc gggattacag gcgtgaacca 59640 ccgcacctga tgcagttgtt gttgttgttg ttgttttaat atctgattat tattttattg 59700 tatttcattg aatatagcac agtttgtttt tacattttct tattgataga cacctaggct 59760 atttttctgg ttttggactg ttactaataa agctgctata cacatcctta taaaaatctt 59820 ttttgtgaac atgttttctt tttttctaag cattttaaat cacctttatt gaggtgtaat 59880 tgacttacaa taaattttat atgctgagaa tgtataattt gataagtttt gacacaggta 59940 tgcactcatg aaaccatcat cacaatccag ataatgaaca tattcatcac ccacaaagtt 60000 tacctttttg ttttaacccc agtcaccggg taactgctga gctccttcct gttactgtag 60060 actagtttgc attttctaaa cttatataca tggagtcatt catattttat gtgctctttt 60120 ttgtctgatt taaataatgc agtataatta ttttgagatt cattcatgtt attacagtga 60180 ttaatagttc attcctctta ttgttaagtg gattacattt tatggatatc caacaagttg 60240 tttatccatt cacctgatag acatttggat cgtttccagt tttgggttat tacaaataaa 60300 actgctatga acattcgtat gtaagtcttt gtatggacat atgttttcat tttattatat 60360 atgacggagc ggaatgactg gaacatgtga tgcatatatg tttaactttc ttttttctaa 60420 ttgagataaa attcacagaa cataactttt accattttaa tcattactaa agtccagtgg 60480 gttttggtat agtaataata tataaccatc ataattaatt ccagaacatt ttcctaactc 60540 ccaaaagaaa ttccataccc attaaggagt cattccctat tttccctttt cttttctttc 60600 tttttttttt tttttgagtc agggtctccc tctgtctccc gggctggagt gcacttgcat 60660 gatcttggtt cactgcatcc ttgatttcct gggctcaatt gatcctccca cctcagtctc 60720 ctgagtagct gggactgtag gcatatgtta ccatacctgg ctaatttgtt ttattttgag 60780 tggagatgag attttgctat gttgcccagg ttgctctcaa actcctgggc tcaagtaatt 60840 gtcccacctc agccttccaa aatgctggga ttacaggcgt gagccactct gcccggccta 60900 ttatctctgt tctgcccact tccaaccact aatctacttt ctgtctctat gatttgccta 60960 ttctggatgt ttctataaat taacttatac attatatggc cttttgtgtc tggcatcttc 61020 cacttagcat agtgatatca gtacttcatt cggtcttttt ttatgactga ataatattcc 61080 atagtatggg catacacatt ttaaaaattc attcatcagt gatggacatt tgggttgttt 61140 cctttttggc tgttatgaat aatgatgctg tgaacatttg tgtaccaatt tttttatgaa 61200 catacatttt caacgctttt gcatatatgc ctaagagtgg aattgctggg ctatatgcta 61260 attttttaag aaactatgaa gcttttgaga gtgattgtat catgggatat tcccaccagc 61320 agtgtatgag aggtccagtt cctccccatc cttgctatca cttagtctgg ctgatcttta 61380 acttaagcca ttctaatagt atctcattgt atttttagtt tgcttttccc taatgactaa 61440 ttatattgag catttttcat acacttattg gccatctgta tatcttcttt gagggagtat 61500 ctgttcaaat cttttgccta ttttttctta gtgagttttg atagtcattt ctatattctg 61560 aatataaatt atttatttga tatatgcttt gcaaacattt tctcctagtt tatggctttt 61620 catactttcc acacagttct tttgaagagc agcagttttt cattttgata aagtccagtt 61680 tgtcgattcg ttcttttagg gattttgctt ttagtgtttt gacccaaggt cacaaagatt 61740 tgcttttatg ttttctccta aaagttttat agttttaagt tttacattta gatttacgat 61800 tcatttttag taaatgttgt ctattgtatg aggtattgat tacagtttat gtatttttca 61860 catattgttc cagctccatt ttttaaaaag actatgcttt tacactgaat tgactttgta 61920 cctttgtcaa aaataaattg actacatata tgtgggtcta ttgctgcact ctctattctg 61980 tgttctgtgg atctatttgt ctgtcttgat tggtgtcttg attactgtag ctttataata 62040 aacctggaaa tcaggtagcg caaggcctct tgctttgctc ttttctttca aagttgttct 62100 ggctattcta tgtcctttgt atttctgtga gcatgtcagc atcacctttt caacccatat 62160 gcctgctggg attttgaatg agtttacctt gaatctagat atcgaaacaa ttagctgtct 62220 tgatagttat tgtcaccgtt ttataccgaa gaaactaggc atactaaagt aacttggcta 62280 acatcactta ccttgtaaga agtagaactg ggctgtttga catcagagct tattctttat 62340 accatttcct atgttaatta gaatacaata ttaatttcat aaaggtaaag gcatatctgt 62400 tttgttccta tttgattcct tgtgaaagca caatgcctag cgcacaatag acacttaaac 62460 ttatctgttg aatggacagg tgaatgcttt taaagtcttt ccatatagaa aattaagttt 62520 cattacattt gacttgatct aggttttcat ttcatagaat ggagagcaga ctctgtaaat 62580 attttgcccc agacctagct ttattacaaa cattgtctta attaggattc tgtctaccca 62640 gaatagaaat taactcaagc tagcatgagt gtatattgaa atttatatta aggataaagg 62700 aatgtctcat agatcccact caaaagaaat tagccagccc ttaggaagag actggaattg 62760 ggtttggaaa atacaatagg tctttctttt tatctgtagt ctttagtgag tcttcctcat 62820 ttttctctct gaagagataa gcattctctg catatatata gcattctttt agattttcgt 62880 gacataaagt attatttaaa ctttcataag gtatcttgat tttaagttgt aattccttga 62940 gatgattgtt ttctttattg ttaatatgtt tcccttcctg tttttttttt tttctttttt 63000 cttttgtttg tttttacaga ggtaaatacc ggattgtata cgtaactcca gaatactgtt 63060 caggtaacat gggcctgctc cagcaacttg aggctgatat tggtaagtga taaagaaaga 63120 tctctgtaaa tacttactga gttaatattt aaagttaaac ctatggatgg acactggatt 63180 tcacttctgt taaagtttat ttcaaacatt acttcctcca ggaaatctct gactctctaa 63240 cttgctgttt cacctatctt atcccatgat actctataat tccttttgct atagaaatta 63300 ggctctgtta tcataattac ctgtttatat atctgttttc ttctgctagg ctataaactt 63360 ttcaagggaa aaatatcact ttttaaaatt tatgtttccc cagtgcagtg cttggcatat 63420 aggcacttaa acatattgtt gaatgaatgt tgaatcctag gttctgtgaa attttaattt 63480 acttgttttt catgttctgt atctaaatta agtcagtgta gtggttttgt accctctttg 63540 ttcataagaa tcacttttca aactttaaaa aaaatgtagg taaccaacac ccaactctga 63600 aaattctgat ttaacaggcc tgggttggca cctggcattg gtggtttctc acaggtgatt 63660 ctgatatata gcccgggttg gaaaccacag tacctttgat tagttgccac tagtgagtat 63720 gatttattac aaaaaccaaa aacttagata agtcacagtt tatttcctag aacgtgtaaa 63780 tatagaatta gtcaaaagct gatagcactt tttttgtact taaaaatatt ttaagcctca 63840 gtatagtgag acctcatctc tacaaataat tttttaaaaa attggccgag cctggtggtg 63900 catgcccata gtccaagcta cttgggaggc tgaggtagga ggattgtttg agcctgggag 63960 atgaaggctg cggtgagcca agatcatgct actgcactcc atcctgggca acagagcgag 64020 accatgcctc aaaaaaaatt tttttttctt cttggtggtt aggcttaact atccaagaat 64080 tgcaatcatg gcttctattg caaatgcccc tatttcccac cttcagttgg cctaaccaaa 64140 tttaattttt caatatcata tgatcttttt gtataattat gtattcaaat aattccagat 64200 aggttaggtt ttcgaattgc aacgtctcat ttaatggtta ctttcatata actgtaggaa 64260 agcatttgat aatttttcca acaatgtaat gaaaacaaac ttgtatcttt tttattatgt 64320 gttaaaacca acaaaagaat gagggcagca attaacattt cattaaatat attagcaatg 64380 agtacattta tgagctctta aactccctta ttgacatact gtattttttg cctttaatgg 64440 acaatgaatt tgatatgttt cctaataggt tgtatgaagt tattgtgaat atttcacttt 64500 ggattaagaa taactaccct atatataaat ttcatggttg tattgcaaaa gctggggtct 64560 atgtccatag tggtttgggt acgtttttac tatttgcttt gtttctgtga tagtgttaaa 64620 tgaataataa gcttaagtat ttaagcaaat acttaatact tctgacaagt agttagaact 64680 ctctattttt gtttttttgt aatggatgag ttatggacac tgcaattatt agagcagcgt 64740 actttgctta tgatggatga aaatgttctc tggttgactc agtgttgaat aaaaagggat 64800 acatgaaata aaaattattt ttgaaatatt ttcctttgcc ttttgttgcg ggaaattgta 64860 caatgcttgc aaaaatgaat atacgcagga tattatttgt acagcagtct gacatttagc 64920 taatcagatt cctcattttt aggtaaatgt taaattactt aagtagtctg gatttttaac 64980 agaaacagca aacatagttt tatagggagg ctccttacca accagacttt taacttaagt 65040 gaatgttggc aaaagcttgt ctaaactgat ttccagggat aaggtttagc tccattaaaa 65100 gctagtttgt caaacctgta actaaagctt tttaaaaaat gaaagtttta aaagagacca 65160 tcattctgtt ttaacctatt taatttaaaa tctgggctga agtaggagta ttgcttgaac 65220 ccaggagttc gagaccagcc tgggcaacac agtgagaccc catctctgaa aaaaaaaaat 65280 gagctgagca tggtacctgt tacagtgcta gttatgaaag aaagaaagag agagagagag 65340 aaggaaggaa gggagaaagg aaggaagggg ctgggagtgg tggctcacac ctgtaatccc 65400 agcactttgg gaggccgagg cgggtggatc atgaggtcag gagatcgaga ccatcctggc 65460 gaacatggtg aaaccctgtc tctactaaaa atacaaaaag aaaaaattag ccgggcatgg 65520 tggtgggtgc ctgtagtccc agctactggg gagggtaagg caggagaatg gcatgaaccc 65580 gggaggcaga gcttgcagtg agccgagatt gcgccactgc actttagcct aagaaaagga 65640 aggaaggaag gaaggaagga aggaaggaaa aatcagtcac tcactcaggt ttagtttcaa 65700 aagccaaaac agtgataata ttgaattttt tccagccact cagtagtacc cagagaattt 65760 tgatacaaat aactgacttt gaccccatgt ttagtaggtt ttttttttgt ttgtttgttt 65820 gttttttttt tttgtctttc ttctccacac tctcttagga ctgttgtagc ttgtaatgtt 65880 agtgaattgt aattgtttat ttgcatgtct gtctcctctt ttagaattgt gaactcctca 65940 ggtcatggat tgtattttat tagtcttttt attcctagaa aagtgtttgg ataataatag 66000 atatttatta accataatag gagtagtagc atttttgtgt gtgtgtgcca ggccctattt 66060 tagcatttta tgtgaatgat ataatttaat ttttagagca tctagaaaat gttaggtacc 66120 attattatcc acattttact tgtgagagga ctgagacttg gaaagcttaa gtaacttgct 66180 taaggtaata cacatggcag atggtggagc caggttctgc atctgggcag tctgacttta 66240 gagcttttta atcatcctcc tcctagtgtc cgaacattat taatgctcag agaagtatca 66300 aagaatgatg atactcattg agggaaaaaa ttattcttaa gtatcaattt gttaattgag 66360 gacaaaagca ctactgttac tactgtgaaa aatctgaaaa cattgtcacg gatgatttta 66420 caataacatc cttttctgac atgcattaca acacactatt gattccgttt caatgtttgt 66480 gtctggtatg ggggcggagt agagaggcta ctacaggaag aaagaacaaa taacatttct 66540 tcttactact ttgtgcatca tgtgatttag ctcctcccat accattttac attagaaaat 66600 gtggctgtcc tcctgtgctc tagtactggc atttcagagg actctttgca atatgatatg 66660 tgatcaatca tggatggcga tgcagttaat ttcagtagaa atttgctgac tctttttatc 66720 tcttttaata gctaatgcat gagataaaat tgaaggtatt accaaggaga aatgcaggtg 66780 gatagttttg gaggcaaagt cacagtaagc aattcatctc tccaaggaat agtgatgaaa 66840 gctgagatcc aataaatgtc ttgtttggat taatacataa atatttcctt ttaaaattct 66900 taaggctttt attcatatat ctcccctctc cctatttcca ataatgattt ttggtgttaa 66960 tatgatgata tttatgcttc tgtttttata ggaaccaaat actttgattt ggttatttat 67020 tctcctttgg agatgtagat gagtttattt tttcctttcg agctttatct tttcctttat 67080 gtgtttttct ttttttacag gtatcacgct cattgctgtg gatgaggctc actgtatttc 67140 tgagtggggg catgatttta gggattcatt caggaagttg ggctccctaa agacagcact 67200 gccaatggta agctttgcca agtctgatgt cccgaaatta cattcttaat aaggagagca 67260 ttcaggattg gggagtggta aagaagctga agacttcact ataaaagagc aaatggataa 67320 tgtaaaaaga gaactatttt tttaaaaatg ctaaagttgg tatataatct attgaggaat 67380 ataatagaac aaggcttgac aaaccttttc tgaaaggacc agataataaa tatttcaagc 67440 tttataggcc acatgtagtc tgtatcacat attcctctct ctgttttttc ttttagtaac 67500 cctttaaaaa tataaagagt tacatttttc actggtgggc cataacaaaa caggctgtgg 67560 gccatatttg tccgaatgtc ttctcagtga tctttcatcc gtatgtcctt ttactctagg 67620 atgctgtgaa atcctggtta ccccttcttg tatcacattg aaaacctaaa gtttgaacta 67680 ttctatagaa attttattaa agcttttggt attagaattt ccctttcttc cctaattata 67740 aaaaatagca aattttggcc gggcatggtg gctcacgcct gtagtcccag cactttggga 67800 ggccgaggtg ggtggatcac ctgaggtcag gagttcgaga ccagcctggt caacatggtg 67860 aaaccctgtc tctactaaaa atacaacaat tagctgggcg tggtggcagg tgcctgtaat 67920 cccagctact tgggaggctg aggcagggga attgcttgaa ctcgggaggt ggaggttgca 67980 gtgagccgag attgtgccat tccactccag cctgggcaac aagagcgaaa ctctgtctca 68040 aaaaaaaaaa aaaaaaaaaa aaaagtgaat ttttacatga atattctaca tgattggcat 68100 atttacatga atggtttaaa aacccacaat aatagcactg ttttattttt tattttgaaa 68160 attgtagatt cacaagaagt tgtaaaaaaa aaaataccta tatagaggtc ctatgtacct 68220 ttcatccagt ttcctgaaca gtaacatctt gtgtgactat agtacaatat caaaactagg 68280 aatatgacat ttgtacagta tctagagttt attcctattt ctctagtttt gtaagtactc 68340 ttttgtatgg catgtgtatt gttctataca gtttaatctc atgtacattt gtgtaactac 68400 cactgcagtc aggatgccaa atgttccctt accacaaagc tccctggagc tgttcttccc 68460 acccctggcc ctagccactg gcaaccacaa atctggtctc tatctctaaa atattatttc 68520 aagaatgtta tatacatgga atcatgcaat ttgtcacctt ttggaattag tttttttcac 68580 tcaacataac taccttgaga tctatccaag ttgtttgtgg tcatgtgttg cctaacaaca 68640 gggatatgtt ctgagaaatg tgttcttagg acattttgtg gttgtctgaa catggactta 68700 cacaaaccta catgataaag cttactgcac acctaggcta tatgatagag cctattgctc 68760 ctaggctgta aacctgtaca gatgttactg taatgaatat tgcaggcaat tgtaatacaa 68820 tggtaagtat ttgtgtatct aaacttatct aatgtagaaa agacacagta aaaatacagt 68880 ataaaagata aaagatggta tacctgtata gggtgcttcc tgtgaatgga gcttgtagga 68940 ctggaagttg ctctgagtga gtgagggagt ggcgagtgaa tgtaaaggcc taggacatta 69000 ctgtacacta ctgtagactt tatacatatt gtacacttag gcgacactaa atttttaaaa 69060 ttttctttaa aaattttctt tcttcaataa taaattaatc tcagtttact gtaactttaa 69120 ttcataaacc taaaacattt tttgactttg gactcttgta ataattctta gattaaaaca 69180 tgaacacatt gtacagctgt acaaaaattt tttcttcctt gattaatgca ttccataagg 69240 ctttatttta aaattttatt atttttattt ttaaaacttt tttgttaaaa actaaaatac 69300 acacatatca gactagacct acacagggtc aggatcatca atgttgctgt cttccacctc 69360 cacgtcttat cccactggaa gttctttagg ggcagtaaca ctcatggagc tgtcatctgt 69420 gataacaatg ccttctccta gatacctcct gaaggacctg cctgaggctg tttttcagtt 69480 aactttaaaa aatgaatacg taggaggagt atactctaaa ataatggaaa agggtatagg 69540 taaatacgta aaccagtaac atacttgttt attattcatc aagttatata ctgtatataa 69600 ttgtatgtgc tatacttttt aatgcctggt agtgcagtag gtttattgac agcagcatca 69660 ccacaaacgt gagcagtgcc ttgtgctaag acattatgct ggctatgaca tcacttggtg 69720 ataggaattt ttcagctcca ttataatctt atgggaccac tgttccacat gtgctctgtc 69780 attgacagaa atgccgttaa gtaccacatg actatttttc ggtggtctgt tcctttttat 69840 tattacagag tattccacag tatggttgta ccacagttta actgatcacc tgttgaagaa 69900 cttttgggtt gttttccagt ttttgactat tatgaataaa gatgctatga acatttgttc 69960 atatctcaaa ggttctttat ttttttttat ttatttttct ttttttgaga cagtctggtt 70020 ctgtcaccct ggctggaatg cagtggcgcg atctcggctc gctgcaagct ccgcctcctg 70080 ggttcacgcc attctcctgc ctcagcctcc cgagtagctg agactacagg cgcccgccac 70140 tgtgcccggc taattttttg tatttttagt agaggcagcg tttcaccgtg ttagccagga 70200 tggtctcgat ctcctgacct cgtgatccac ctgcctcggc ctcccaaagt gctgggatta 70260 caggcgtgag ccactgcgcc cggccttcag agattcttta atgggtgaat ggttaaacaa 70320 cctgaaaata taaaagtttt catttctctg ggataaatgt ccaggagtgt atttttagtt 70380 tttaaggaat tgtcacaaac ctgttttcca aagtggctgt agcattctac attcctgtca 70440 gcagtgtgtg aatgatctag ttatccttgc caccgtttgt tgttgcaact gttttttatt 70500 ttagccattt cgataggtgt cgagtggtat ctcactttta atttgcattt ctctcatggc 70560 taatgatggt gaacgtcttt tcatatacta atttgcctct ggtgaaattt cttacataat 70620 tggagtgctt gtttttttct gttgagtttt aagagtttaa aaaatacatt gtagatatga 70680 gtccttggtc agatacgtgg tttcaaatat ttctttcact ttgtagcttg ccttttcatt 70740 ctttttaccg tgtctttcac agagtaaata tttaacattt tagtgaaatc cagtttatca 70800 ttttttcttt tatggattgt gctcttcacc tagccctaga tcctgaagat tttctcctgt 70860 ggttctttcc taaaattgtt acagttttat gttttaagtc tgtgatccat tttgagttaa 70920 attttgtata aggtgtgagg tttaagtcaa ggttcattgt tttcccaata gattaaattg 70980 cagcagatcc tttgttgaat aggctgtcct tcccctgtta aattgcgttt gcccctttgt 71040 tgaaagtcat gtgggtgtat ttgtgtgggt ctatttctgg gttctctagc ctgttatatt 71100 aattttgaac gaataaagtt ggcttatgtt taagttttct tggtagtagc gaggcaatgg 71160 tgccttctga gcccaggatt tcacaatttt gtgagtaaac tgtgttagaa attgtttgtt 71220 attcttttgg taggttgtct agttcaattt cattgctcat taatcttgct tatagatagc 71280 aaattgagag gcatctcaaa aatagtatct tttgttagct tatctcacag agtttggttg 71340 gagcagatat taaaacaaca aaccaaaaat aaattaaata tactagttag caagtttata 71400 ttgagggaaa atcaaaccat gtgaattgag ctccaatgat gtggctggcc ttgggtcaga 71460 ttttagtatc atggttcaac aaggtagcta ttaaaatctt catacttttt cttgaaataa 71520 ttctttagta gtcacatagg acagcacaca ctcatggatt tcttctttcc ttactgtctc 71580 tttattctca gcctcctgtt ccttctcatc tccctgacct tttaatgttg gccttccaga 71640 aactttagtc tttggaccta cctttgcact cattttcttg gtcatttcac ccaacataca 71700 gttttatgtt attttatttt ttttattttt gagatggagt ttcactcttg ttgcccaggc 71760 tggagtgcaa tggcgtgaac tcaccttact gcaacctctg cctcccgggt tcaagtgatt 71820 cttctgctca gcctccccag tagttaggat tataggtacg tgccaccatg cctagctaat 71880 tttgtatttt tagtagagat ggggtttcac catattggcc aggctggtct cgaactcctg 71940 acctcaggtg atccacctgc cttggcttgc caaagtgctg agattacaga tgtgagccac 72000 cacgtccagc ctacagtttt aaatatcaag tctatactga ggactcccaa atttttatct 72060 ccatcataga ctgatatcag cagtatatga gtgattcagt tgtttttgcc tctttgccag 72120 catttggtgt tgtcactatt agttcatttt agccatttaa tagaatatat gtacatatat 72180 atgtgtgtat acacaggcac acatctatat aactactcaa catgcctctg gtgagatgac 72240 caacaggtat ctcaaactta acctcttcct aattgacttc tgcatagcac tccagatctg 72300 ctctttcctc actctcctcc atcttgttta acagcagctc cattggccaa aattttggaa 72360 ttttcctcaa tcttttctct ttttcttaca ctccactgtt tatttaaaca gtaaggaaat 72420 ctcgtgaggt cttcagaata tatgcagaat taaatcactt ctctcttgat ccctgccatt 72480 ccccaggtac gggccaccat ctccttaggg cctcctgctt tcactcttcc catccctcat 72540 tctgtttcaa cacagcgtcc agagtgatac tttaaaaatg aagtctgata gatcatgtct 72600 tcggctcaga accatctagt agcatgccat ttcattctaa ataaaggcaa aagtccttat 72660 gatgagttac cgatcctcat gtaatctggc cttccatttt ccctctgatc tcattctcta 72720 ctggtctcct cattcaccgg atgcagccac accaccctcc ttgtttttct tcggacattc 72780 caggcatgct tcagtgcctg ggctttgcgc ctgctgcttc ctctccctga atacgtttcc 72840 cccacattgt ctataggatg ttctcccata cttctctcag atctcttgga tttaggcctc 72900 ctgggccacc atatttgaaa tatcagatta gttccccctc ccccatcatt cagcattcct 72960 cgtaaatctt tgctgtttta aaaatagcac tatcactgtc taacttactg tgttatattt 73020 tgttaatttt ctgtgagttc ttcttcacta gaatattctt tgtagggagg agtttttgat 73080 tgtttggttt ataaaatctg gaacaatacc tggcttatag gaggtgctca atttataatg 73140 gggtgaatga atgaatgaat gatgatgaga aagctgagaa tcagtaaagt gactttccaa 73200 aacaggtagt gggcagtata gagttgggcc ataaatagct gcaccataca acatcctgct 73260 agtttctaaa gcaaatgatt tgaaagaggc ataaaacata atttctgccc tcaggtagct 73320 catagttcag taaaggagtt tagattcata cctataacag tagaagtaat agcaccaaat 73380 gaaatatggt attatgaagt ggtacaaata atataaaaag atgaacagtg ttagtagtac 73440 atgtttagaa gggatttctg tggtgaaagt cactaggcac agtgcacctg gaggaccgat 73500 ttccattaat ttagaatggt ttaaagtaag cttttggaaa ctaggaagat tactttctgt 73560 aatcctttcc taggcctttg attctagaag gattgtgtta aaggagtttt aaatatttta 73620 tacagttctt aaacattgtt aagcttgaat taaatctttt attatgtctg gccatggacg 73680 tcattggatc attttcattt cttgggagga ttaataaagc acattccttc tgttgggcct 73740 ccagtgcggg gagggtgttg gccgagcagt ggctgagaaa acgtttttcc cctggtgttt 73800 tcaagaaccc tctttattag ctaagtggtg agacatgcca cctggtggtt atagtagtat 73860 catttttctc actgttcttg gtgcttttct tctcgttctg attccagtta tactaggaca 73920 actgctataa acctggaatg tttcacacta tattatttca gtaatttcaa aaacagcaga 73980 aatcactaag ctgtttggca caaagattcc tatttggaag gaatcagaca aagtgagtgt 74040 tgagaaagaa cagccaggca gaaagctttg catcagtctt aaagttcttt acatttcaag 74100 taagaggaat tgtgaaatcc ataagacatg tggggttttt ctattacttt ctccccagta 74160 tctattacaa agatcagcac atagtaggta ctcagtaact atttagaatg agtgcatgaa 74220 tgaatgaagt atgtgtgatg ttatggagta caaagttaga attagcaaca tgacctgaat 74280 ttagaagcag gtgggatact tatacttttc tcagtctgtg ggcaccacac cattgaagta 74340 tatgtctaag attaatttat atttggttgt ttgatttagc aaaacttgct gcctgttaaa 74400 aaagaaatta agacctgtca acttaaagaa tacattttgt gagttaagaa ctaaatgaca 74460 gtataattta ttacccaaag cagtttgctt ctgaaaatta aagagttcaa gctattaata 74520 attatgctgt gactgcaggc ataaactggg aatgtcctgg caaatgagga tgtattgtca 74580 cctttctcag cctgcctgtg tgttgttttt aagcttcact ctagtttata tattttaaat 74640 gtcataaaat accacatact tataagagaa aaggttctat tcattgctga agtggaagct 74700 tatcattaat ttttatttat ttattttttt ttccagtttt ggaattctta ttactttgaa 74760 cccaagaacc actgataact agcacaatcc agtgaaacag aggaagcagc agcttaatca 74820 aaggaaaaat acatttaaga ttataagtct ggttataagc ttaaaaagtg acccagaaag 74880 ggatatcatt gctaaaaaaa aaaatcccct tgtgacctgg gtacattttg caaagccaca 74940 ggtttgcagt gttacacaag ggccaaagga ggccatgagt tgtctttggt tgtggggccg 75000 gagggtaact gttcatgaaa atagtgagtg tctgaagatt aagaaaatca tgctgcagca 75060 gaggagaagg gagaggaagg caggaaggga aaggagatgc ctgagggtca aaagctgagc 75120 ccaagcctaa gcccaagctc aagttcaagc cccagcatgg cacaattttg tgaattaact 75180 caggctgagt tgcctccagt ctttggaatg tcatcttata ctggtactgc tgaggcagag 75240 ggcagtaatt ggttctttgg gataggagaa ggggcagttg ctgaaataca aaattaatag 75300 tcagcatccc aagttcctca attgcagcca aaatacatgt gttcaggcct ttcggcagta 75360 ccgcccccag aactaccagc tgtagtgtgg tctattccca gacagcaaca tgcaagaata 75420 agtttacaat acactcagcc cttgtggctt aagatcaggg gctcagaggc tgtgacaact 75480 catgatgctg aaaatgtatc caatgaaaac gaagtactag cttgtttagt agtaacgaag 75540 tactattaat ttttaatata gtctgatact ttattttcta attgtagaag caacattctt 75600 agctatatct ttctagaatg ttgaggcaaa agagtaaatt tatagtgatt ttcactgtta 75660 ccagattgct ggaataggga atttctggta gcaagatggg aatttttaag ttggaagggt 75720 ctaacacatc atatagccgt ctccatctca ttttttttgc tgaaaaaact gagcccttgc 75780 aaatgtcagt tgcaaatctg ggagtagtac tcatgtctct gaagttgtta tatagaattc 75840 tttttattta ttttaataac aatatttatg atagttgaaa ctttttgagt gcttactata 75900 ttttatttca tgcattatgt tcagcacttt acatgtttta tctcacttga tattcacaac 75960 tttatgagat tggcactgtt attgtagcca ttttatagat gaggaaactg aagcttagag 76020 agttaaataa agagctcaaa atctcacatc tagtaagtgg caaaaacagg atttcagctc 76080 aagcaatctg attccaaaac agactttttt cactgtgctg ccattctttt gcctggtttt 76140 tctgttaact tcttaaatat atgtcatgtt tcatgcttac ttcctcattt tcataaatat 76200 attacctgct cacttataca ttatattgct tagaaacaaa cccaaccctg ttttcttatg 76260 gactgtatcc tgaaaatcac tgtttttaat atgtggttaa acaagtgttt tattagtgca 76320 tttatataaa ttatttaacc aaaacactta accggtgaaa gtgctttact gtgtgagaat 76380 gtgcatgttc taagaacctc taatttttaa acctccctta ttctcagcct tatatttgtt 76440 aaaacctgtg tgttaacaca gatgcaccca tgttaggggt taattagaga aaccaacctc 76500 tttatagatt agcttgttca tctttaagtt gctaggcagg cactgtaaat tcagagaaca 76560 atctgattgt aagccacaaa tcaatgaaat taattttggg gttgcctttt aaaatagtgt 76620 cacaaaattt aaggataaag aatgcaaaaa tgatgccaat tatctcatca cattagtttt 76680 gatttaattt ttttaatttg aaaaaaccta ctcttaaact taattgattt ttttaaatat 76740 aagtttggag ataattttta attcagtaaa gttatagtga ttgaaaaagt agtttataat 76800 ttttaataaa ttgatcttgt tttaattttg agtcatattc tagaagtgct tctttgcaaa 76860 ttggtaaatt gcacatacat ttccacttat atacaagata attgctatgg ttggtttgta 76920 taatagatgc agtgcatctg aagagctatt ttatgagaat attgtttctt gtatctgtca 76980 cgagccaaaa agaatatttt taagaaagtt atattcttgg tgatagaaca gctgataatt 77040 tagaaacaac tgtaagacag tccacttttt ctgattatga aataatacca tagttaagtg 77100 taatttccta taatagaata aaaacacgag ttctagtttt aggggaggca tgttgttacc 77160 gtaccttaga atttctggaa gatgacatat tcatgctttt cctgataact gctgagtctc 77220 ctgctctgtc tgccaatcca gtcaagaagc ctttgctagc aatcaattaa taatacgttt 77280 catttataca tatttcctat atatagtatg ttattgatta tctcagtacc actgaagaga 77340 ggttatctgg gtcattggag ctttgcttct agatttgtga agccataaac ctatatattt 77400 aaaataggag gccaaaaaaa aacgaccatt gctttatata gttagatttt cagtgaattg 77460 agagtttatc atttgtaatt atacattaat caaatataag gcataatata cccccctgct 77520 tatatcagca ccatttcaaa tgtaatgtta aaaaataata aatggagaag tagatagcta 77580 acaagtaggc ttaatttaat aagacaaagt aaatggcatt tggaaacctc atggatttaa 77640 tgttttattt aaatgatttc tgatttttaa aaagtaaata ttgtttccag aaggctgaga 77700 aacaagttag tagggagatt ttttctttgc aaaaaaattt tacagttgtg tctttaacat 77760 tgtaccacaa actgttgtcc taccagtctc tttgtaagaa agctatagac atgttgggaa 77820 tgaatgagct ctttcctttt taaaatatca gttttacatc attcaggttc caatcgttgc 77880 acttactgct actgcaagtt cttcaatccg ggaagacatt gtacgttgct taaatctgag 77940 aaatcctcag atcacctgta ctggttttga tcgaccaaac ctgtatttag aagttaggcg 78000 aaaaacaggg aatatccttc aggatctgca gccatttctt gtcaaaacaa ggtaaggatt 78060 taatggttga tgaattttgg taatgatttc cttttttttt ttttaacaac ttatgtattt 78120 tatgttattt acgatttcct tctaatgcat atttaacata tttcaaattc cacctagttt 78180 tggttcaagt caagcatgat gttatataat caattcagtg attgagacta gtgtattttt 78240 aaaagcagaa accaattctc ctaatatttt aataccccat tctgttgctt aaacagggca 78300 tatactattt atttttattt tttaaaattt tacttattta tttatagaga cagggtctct 78360 ctgtcgtcca ggctggagtg cagtggtgtg atcacaactc actgcagcct caaactcctg 78420 ggttcaagca gtcctcctgc ctcagtctcc caagtagctg gaactacagt cttgcaccac 78480 catgcctggc taggacatat acttttaatg attgataagt aaacaagcaa acataaaatg 78540 actctttcat ctgaattctg tctagtttac taattacatg acttcagtct taaggagctt 78600 agaaaaggtc accttacaaa cacagtggag cctgtattgt gttccaagga ctattgtagg 78660 cgctttctat ataaaatgat ctaatttaat ccctataact gctcagtaag ttacgtatta 78720 ttttcatttt attgttgagg aaactggcat tagtactttt ttctgtttat tttgtttaaa 78780 ggcattttaa atatatatgt taagaagttt tcaaaagcct atattttact ttttataagc 78840 ctttatttta ctatttgaga cagtgtcttg ctctgtcacc caggctggag tgcagtggcg 78900 caatcccggc tcactacaac ttccacctcc tgggttcaag ctattctcct gcctcagtct 78960 cccaagtagc tgaaattaca ggtgtgcgcc accatgccag gctaattttt gtatttttta 79020 gtggagacgg ggtttcacca tggtggccag gctgatctcg aactcctgac ctcaagtgat 79080 ccacctgtgt tggccttcca aagtgctgga attacaggtg ttggccactg cgcctggcca 79140 gtttataatt ttaaacatta aaataaatgc ttcttgtcca atcatggtgt ctcacaccca 79200 gaatcccagc actttgggag gcagacgttg gagaatcact tgaggccagg agttcgagac 79260 cagcctgggc aacatggtga atccctgtct ctacaaaaaa tacaaaaatt agctgggcat 79320 ggtggtgcat gcctgtagtc ccagctattt gggaggctga ggtgggagga tcatttgagc 79380 ccaggatgtt ggggctgcag tgagctgaga tcacaccact gtactccagg ctggatgaca 79440 gagcaaggcc ccgtttcaaa aaaaaaaaaa aagcttctac caatacaaac acaaaacaag 79500 catagacaaa tagagtttaa agaacatcat tggtgttttc ctctaaaggg aatattgatg 79560 ctaggccaag aaaatcctgg agttattctt gaggacctta aggaataatt gaaatgtagg 79620 atttgctcct ggctttcttg tcctatattc agaataaaac aagaatggat cgaatatatt 79680 ctgagtgttc tggccattct agtgctctct gaagtgagta ctcactgtgt ttcacttccc 79740 tttcatccta aagaggaaaa gttcttttga agaaggctgt ttgtcctagg ttagagtctc 79800 cacagtcaga tcattatctc ctcctaatct ttgatcctgt tcagtctcta tggtactttc 79860 ccttataata acactctcta tggcactttc ccttataata acactctcct ttttaaagca 79920 gtttgccttt tttgtgtgta atattgttct cctggttttc tgacgtcctg gtcctcttat 79980 aatcctatgc aaatgtttct ttctgttttt catgttgact ctgctaattg aggtctttgt 80040 tactttttag ccgagactat tataatttcc ccaacagata cccctctccc cagtgcccct 80100 tgttgctttc tatgcagttt acaaattatt gtctgcaaac acatccttaa gtctggaata 80160 cctttctgga actccttact aggaaataaa gaccagactc agtgtaacat tcaacagtat 80220 tgaagatcta ggtatttaat atgaattttt ttttttaagg agatcaagaa agatttttgt 80280 acccattttt aatcctccaa gaagacttag gatagcagga aaccattgag agtcagaatg 80340 ctttctacag atcttaggtg aacagaaact ttcctcttca tgagcagtga ggtagagggt 80400 aattaaggct tcagagcatt gcccgttatt tccatcttct tcccttcctt taattctgct 80460 aaattccttt aatttgttta tcagtattca agtattttta tccattgagc taaggtgttt 80520 cttaaactaa ccctattttg ttaaagtctt aattataata tattcatagt acatttaagt 80580 gagatagatg agtctctcat ataatttagt ggttagatta gattagaatt ttctcccctc 80640 agaaaattaa gaggaaataa aagtctgtag caaatcactt ggcaaaataa tggctccttt 80700 tgtaatagga atttttactc ttttgattta tctgttacat aagttcaaat ttttacatat 80760 tttccacctt ttttaaaaaa gagtgatatg tagtcaatat caatttgagc aacactgttg 80820 catataaatt gaaaaggact ccaattttct aattccgtac ctcagttgtg atcactgttg 80880 gtattttggc atttatgtag acttcctttc tctgacccta ctactgtgca gatatatagt 80940 tgcagttttt tgttgttgtt aagttgatac agaaatagtt gcatactata tccattattt 81000 atgcaaattt tttttcattt aaagtatctg ctatctttcc atatattgca ttttcttaaa 81060 ttagagcctt aatatatagg atattacaat atctaggttt tgttgagtag ttttttcttc 81120 tttgaaaaca tgtttttaaa ataaggtttt tttttttttt tttttgacat ggagtcttgc 81180 tctgtcgccc aggctgtaat gcagtggcgg gatcttggct cgttgcagcc tctgcctcct 81240 gggttccagc gattctcctg cctcagcctc ctgggtagct gggattacag gtgcatgcca 81300 ccatgccctg ctaatttttg tatttttagt agagacgggg tttcaccttg ttggccaggc 81360 tggtctcgaa cttctgagct caggtaatcc gcccgccttg gcatcccaaa gtgctgggat 81420 tacaggcgtg agccactgtg ctggccttaa aataagattt ttatacacta aaagaaaact 81480 tacatttttc actccattaa gtagttcact gtgaattttt gatattgaag cccatttggt 81540 tgctgtcaaa aatagatttg aacagattat tcagtatgac tcttgtagtg aaattattgc 81600 cttgtttcct ctgcttaagt tttcagtggc ttttgccaca gtccttaaag gttttataat 81660 ttttttaatg tttaattttt aaatgtttgc ttaatatttc ttagtatgag tgtagataat 81720 gatgaacatt tagatgactt tttactatta taatgttgca gtgaatattt gtttacattt 81780 atcttttggc caataagcaa atatttttgt aaattagaat cctaaaattg aaattggatc 81840 aaaagttata tgcacttgaa attgattaac ttttcctaaa tctaaaatag tatagtcttt 81900 tttatattgt cagcataaat gaatgcactt atgtaaatga atatttttag gcgttaagta 81960 aaatattctg tggaaattga acatttaagt tgtttatact tctatggaaa tcgtttacgc 82020 ttttaataaa gaagcacaag tttctacaaa atacattcta acagatgttt tctataacat 82080 tcagtctcaa gattactagt aaatacttct ttgaactgta aaagcaatct ttcaatatta 82140 taagaaagct cttgctttag taaacattta gaaactcagc tttattatca taagcaagaa 82200 taagaacagt gtaacaagtt ttatgcacac tcctttgtaa accctcacca gactaattgt 82260 taatctggtg ccttgcattc cccaaagtat ttgtatctgt cgtttataag tttttatcaa 82320 ggtttcagct aaaacaaata aatttgtttc tggttttagc tttaatttga actgaaacag 82380 tcaaaactga gttttgggga cttcacacaa ttcatttgga tatttgattc tccataatgt 82440 tttaaatttt catgcactta aatatatcat tatttttgat aggctttctt cctttagtct 82500 tttctttaga aggtagaaag gaagaattaa ataagataaa accaaacggg tctgaagcat 82560 gtataaagta tatatgtttg ctcttttgtt cttctttttc tttagttccc actgggaatt 82620 tgaaggtcca acaatcatct actgtccttc tagaaaaatg acacaacaag ttacaggtga 82680 acttaggaaa ctgaatctat cctgtggaac ataccatgcg ggcatgagtt ttagcacaag 82740 gaaagacatt catcataggt ttgtaagaga tgaaattcag gtatgaggat caatcatcat 82800 tgctctccgt tgctcatagt ggaagtggat atttctcaaa tgtttattta ccagatcttt 82860 attgaatact ttctttgtgt tgaacataaa gcagtccctc tgataaatgt gggagaacaa 82920 acttgcagat tagtataaat agcaatctgt acctagtgct taggtgcaca gaggagggag 82980 gaatagctct gtcaaggtag ttgtgtaatg ggggtggtcc atccaggaaa attcaattag 83040 agtccaaaca tgtaagtaga agtttttcaa gtatgccagg ccagtaggtg atgaggggaa 83100 aggaattggt tatagaattc caggaagaag gactagcagg tgcaaagaca ctttgatatg 83160 agaacacata ctgggttcag gaaatgtgac tggtatggaa tggttggagg gaaagacaat 83220 gtggggtagg aatggcacaa agtatggaca aagaggcagg gtggaaccgt tagagacttg 83280 agagaacagt tgaatgggtc ggttggccag gttatagatg gctttaaaac ttgcaaagaa 83340 gcagtctggg cttggtatca tatacctgtt agttttcact gactacttta gccttagaat 83400 ttttagttta gatacaattt tctgtaatag gtaaaacgga ttaaagtaga ataactctgg 83460 ctgaagttaa tgtgagggaa aaggaggtac aagagtctcg tctctagacc ttgaagacac 83520 tccctgttgg ggtcttataa tccttggagt gccgcagaat catttgaaaa ccatcttgat 83580 gtactactct gtgtttttaa ataagataat aggattatag aaacattaga ctggcagcaa 83640 taagttggat tgatttgaag aagagaaact gaagaaggga aagggtatcg atgcagctat 83700 tgtgaaattc tacagttgag attcctgacc tgattggact ggctcagtgg gtgtcataga 83760 ggatttattt gggaggattt aagttcaagg cacatgagta ggtttaagtc aacaacttga 83820 cactgtcaac atgaaatcca cactgtaact ataagtccga ggaagagccc tctcctgaag 83880 ttaggaattt aacttcagct cttgcatttt ctgtcccacc ggtcatccat ttcttctcta 83940 tccatctcct tttctgatat ctagttgtta tcagtgttgt tgaaaagctt aagtatgatt 84000 catattcact gtctataaag ttcactacac atagtcatgc tgtaatgcat acccgcctga 84060 aagcatctgg tctctctttt ccttctttcc aaagataaga ataccattca cagctgttta 84120 gaatagaaat tttatccaaa ttcttcagtg tttatatttt tgttctgtta tttcagtgtc 84180 ttgaatattg tcaaatgaca tttattagct actactggta ctactgaatc ttaataatca 84240 atcttcaagc cattaactga ccaatggttt cttctatctt aatgtattag taattattca 84300 tttagagtaa aacatctccc agaacatgaa agaatacaaa ctttattcat gttacgttgt 84360 gacaggagac tttgttggat gcgcctgatt ttcctgccaa ttcacagctt cattaaaaca 84420 gtaatgcttt gaaatatggc ttaggaaact tcacaatgat cattaattac acctaatttc 84480 tggaagagta tatgcatgta tgtgttgcgg tattctccct tgctgtggca ggatgtcaca 84540 aatttttatc cacattacga aaatttaaaa attgatatgg ttttttctcc ctacgttgat 84600 atcagatatt ttgttttatc tgacagctgg cccaatgtac tcctactttg ccattataaa 84660 gaattcaaaa gcttcatatt tgcattgaaa gttctcaaac actttgtaaa gatgatgaaa 84720 gtatgtttca tcatctatgt agaatagtca ggtgttcttg caattgatta cttgctaccg 84780 agaattgaat acctactgag tgcataatgt atagaattct agatattcac ttttgtgtgt 84840 ttttacagtt gttatatacc ttagtgtggc tctaaaagtg gaggtgacag ctgtagctct 84900 taatgtctta cactgagtga tgtttagaat cttaaatttt cttttataat tttagaaaaa 84960 agtatacttt tctttcttat ttttataacc agatccaaac acatttgcat gtagataggc 85020 atttttagtc ttgaacattc atttttactt ttaatcctca cttttattag tttcgtatct 85080 ttttgtattt catttcccct ttcaagatgc cttgagtcct ttctttttag gaatgatgtt 85140 gtgaataaat tatttgataa aatgtcttta cacctgagag tttataagga tagtttgaaa 85200 atcatgtctg taaaataggt tgatctcacc taaaaataat accatataat taaaattaga 85260 attattattg tgttgcttat tgactcttac atatatcaaa aaattgctga gtcttattca 85320 gccagagctt ttacttagta tgatattcat tcctatattt acttttttct cacctttctc 85380 atactttctt ttacttactc agcattttcc tcctttcctc cctcctttct tttcttcttt 85440 ccttcttttc tcttcctttc gtattcctgg tccatcttag catgtaatct ttctttatga 85500 aatggcatgc agataggtct actgttctta cagtaaaaaa cttcaaggcc tcatgtcttt 85560 cccacttctg tttcccattc acaacctttt tagctgattc ttttggtact ttaccactat 85620 atcttgccat agtttatgta cctggctcct acttaatttt ttgtttattt gtgtattagt 85680 cgtaggcatt atttatcgac tcttctctct gaaagatgaa aggttagctc tctttcacat 85740 tcttaactgc ccttttttct taccttgtcc atgtatttct aacccccttt cctcctaata 85800 tgtttatgtc ataattttgg ctagattagt gtatacgatt tacataatta ttactctgta 85860 aatgcttttt atgatctctg agccatgtag tatattatgg ctatttttct ttcttatcta 85920 tttgtatttt tattgttatt acctaaaaaa aaattttcta tgtcttatca ctaattcttc 85980 cctaaaattt cccacaattg tgtaaactta cctcagtata ttcatagata tgagacattc 86040 tatcaatttt accctcttaa agatgcagag ataatgcatt atgtttcatc ccaccatctt 86100 taatgagaag cttccatctt agattaatat tagagaatgt taaaatactc tgcaatcagg 86160 taaggacgct tgaaacttca ttataatgca aaagttttct ttaacacaat aaatattttg 86220 aacccctttt gtgtcttgta ttcataggag ttcagataga ccactttatt tactattttt 86280 tatagagagt gaacagaaat cccatttcta gtcaccagtc cttaatctgt aaatcaggca 86340 gataatctgt aaatgattgg ttgaaatcac attgaattcc actttgtgcc agggacttaa 86400 gttaacgaac aaattattct tacaaaaagg tataaatgta aggttttcat tctgctaaat 86460 atgtttgtca aactgtgttg tgatttgttc tcagtgtgtc atagctacca tagcttttgg 86520 aatgggcatt aataaagctg acattcgcca agtcattcat tacggtgctc ctaaggacat 86580 ggaatcatat tatcaggaga ttggtagagc tggtcgtgat ggacttcaaa gttcttgtca 86640 cgtcctctgg gctcctgcag acattaactt aaataggtaa aaaaaattta ttgtttttac 86700 tcttgcagat ttctttcttt ctttccatat aaacctcaaa agtgtttgag gctatttcca 86760 gtatcccaag taatttgtga gtgcatttaa agtaaaaaaa aaaaaaaaga aaaataaaac 86820 ctccccaaat ccagaggaca tgtaagaaga acatttgtgg taagagttgc cacttggaga 86880 tgagctaatt tcagcatgcc ttagttagtg tgaggaatta actaaatcag gacaatactt 86940 gggcctgtca cagagatcct atggaatact ttcctaccat tgtgcattaa tgaacaggtt 87000 cttttcctct cctcagatcc tgtcaagttg cgatgtcttc agccatagtt acttcaacta 87060 ccactgattt tgttactgat tctttcttcc catgctacag tggtgattat tccagaggat 87120 ttctctcagt ccctatttga ctcttgttac tatttgtttt cttggttagt tccatgagac 87180 catgccagtt ctccttgact gtgtatgaat cattgtgttg cactgtactg acagactgcc 87240 gtaagtcaat attaagtgtt cagtatctaa gtgcaggaga acctttctac ttaagtactc 87300 aacaagtagt ttgttggcac ttaagttcta tgagattttt tgttgtaaag gaaaacatta 87360 tcttgcaaag attttggggc agcatttacc aatactttgt tccttcatcc gtaggaaaaa 87420 gaatctcagg agaaaaacct atacatggta accaatgggg ctgccaagct gatgaagtat 87480 tttcagagta cacctttgtg tagctgaata aattgagatc ttgaatggac atattagctc 87540 attttagtaa aatgataaga gagtgcctcc cactacagtt tttgttttta tgcatcatta 87600 aacaatgtgt ttttgattgt ccactgtgtt ccatgaacta tgctatgtgt gggagatata 87660 gtagtaaaga aaagcaaagt acctgcttcc atagaattca gtataatggg aatggtaatt 87720 ctttagagaa tcacataact atggatacat aggcttcatt ttactgttct ccttttgtgt 87780 ttgaaaatgt caacaatcaa aattttgtaa aaaaggaatc atgcaacata tttaaaatta 87840 taactgtgtt aagtgtaatg aagggaaatt gcactgagta gtaagaatat ataatggtgt 87900 gtggtatttc ccaagttaaa aaggtcagat aaggcttcct tgtggaagtg atagttcaaa 87960 tctgaaagaa gaataggaat taattaggta aaaatgtttg atgcaaattt taagattttc 88020 cttctgagta gtcagtagct tttccttctt aacatagaag atgacaaaac catccttttt 88080 ttgtacataa caattcttgt tttcctttag acagttgtat ctgtcaagct tcttatgatc 88140 taatttaaat aattgggata gaacacagct gtacatgtta ctattaaata tggaatatat 88200 caaacataag ttgattccta ccagttctga ttttatttgt gtattttgtt aaaggtactg 88260 aggacattaa tatccagttt tatattgtgc atttgaaggt tcatcaataa atacaattct 88320 tgtttctctg ggtcttaaaa gatattttaa atggttatct cattaagatt taacaggaaa 88380 taacagtgat tcaaatcaaa tagtggtgcc agaaacccat acttgaattt tgggtataga 88440 caggttaccc tttgcatcaa tcctgaggaa actaaaacta taggattaat caggataaaa 88500 aagaattgag caaggattca ggagggatct gtatcatcct ggtgacaacc ctcttctaga 88560 aaaaactaga aagtctaaga ataaatgaag ttgctggttc tcacctggaa aggtcagtta 88620 ctcacaaaat ttttagagtc tatcttatgc cataattcta tcactgagag aagaaacttg 88680 tccagtcatc atgtaatctt catgtaaatt tatgttttta attgcagaat tcataccaca 88740 ggcaaagtcc caatgtctgc atttgctgtt accttaaata gtcaaacccc aaagttattg 88800 taatcttttt ttaacagaga ataatttgca gagtaatctc ggtccggtag atctttcagt 88860 ggatccaaat gattgccatg aatggtttag aattttttta attttcaagt tgtttttatt 88920 ctgtggaata ctggacttat ttttgtagtc ccaaaagaaa aataaatatt tatttatttg 88980 ccgttaagag ttgtagtttt gttttctcaa atttgtcctg acactgacga gattagttaa 89040 atgtaggtca tctgaaccaa atacaaggaa ggaaggaccc agttctgaag agtgtgggca 89100 tttcttttct tgtttttttt tttttttttt tttttttcta taggagggga acgaggtgaa 89160 ctaaacaaac aaaataaagc aaaaaagaac tgatttttat cccttgaggt agaaagaatg 89220 agattacagt ggaccccctt gtctgcattt tcactttcta tgttttagtt actcacaacc 89280 acgtccaaaa tgttaaatag aaaattccag aaataaacaa tttataaatt ttaaatcagt 89340 ggtggctttg agtactgtaa tgaaattttg tgccatccca ctcagtctgc ctcgacttcc 89400 cttagaatca tccctttgtc cggtgcattc acgttgtatt tactccctgt ctgttagtca 89460 cttgttgcag tatcacagtg cttgtgttca agtaacgctt attttactta agaatgaccc 89520 caaagcacaa gagtactgtg cctaatttat aaattaaact ttttcatagg tatatacata 89580 taggaaaaaa cataatacat acaggatttg gttggtacta ttctgcggct tcaggcatcc 89640 actggacgtc ttggaatgta tcccttgtgg ataaggagga actgtatatg gttaacctag 89700 gagctagagt caacagttgg aagagacttt ggggataatt acatggaagg gcatggtggg 89760 tggtcgtttc agatgacaag aatgtttttg aataacggat catttgtgtc ttcagacttt 89820 ccagaactcc ttgagaatta tgcagaggta tttaatcagt cagaaggttg aatagtcaaa 89880 ttattagtga gtgaagtcta ttttgatgag gattttacta atgctgtccc ttagatatta 89940 taagtaaatc gttgttttct tttgaaatat ctgaaaccta gttaacatgg actttcattt 90000 gttcttgtaa agatatgcaa agctatttgg gagattgtca tcatctgata tttgatattc 90060 atgggctttc ttcacagaag actagaaatt aacagagtca tgatgaatta tggctgcatt 90120 gactttaaaa aacaaacacc tccttaatgt tatttaacaa ttttgaataa atttgatatg 90180 gcaaacaaat cagttataat cgattgagaa aggaacttaa ttctaatact tgactggtgt 90240 cccataataa cccataatac taagagacag ttttggaggg cgagaagtcc tgaagagctg 90300 atagagataa aggttcaaat ttgagcttct ttcagtgttc cttacgtcaa tgcttttagt 90360 ttctcataca aaataaaata aagaataacc tttttactgg gaaaaggtaa aaattaataa 90420 attgtagaag cattgtttga agccaaaaag tgtgtgacat gtaaattgaa atgaaaaacc 90480 ttagagtttt tgatactttt tcaaagcagc taaagaattg atacttggac acaggaagaa 90540 ttttttttca aaagcaattt ttataaaatc agaaaaatgt ttacctcttg ttgggggcat 90600 tgactggaaa ggaatacaac agaactttct gagatgctag aaatgttttt ttatcttgat 90660 ggggtgtggg ttttgtagat aatgaaaaat aaacagtaaa aaataagtaa aaaaaaaagt 90720 aagaaagttg ccaatacagt tttacatatt cctgtgatgt ttttaatcga caggcacctt 90780 cttactgaga tacgtaatga gaagtttcga ttatacaaat taaagatgat ggcaaagatg 90840 gaaaaatatc ttcattctag cagatgtagg agacagtatg tattatttat tttatgccaa 90900 tagtatggat ttatggatga tgctctttta agacaacaat ttggctaaat aattatcagt 90960 attttgaaaa aatattttgt tgctgttaca tgtgtgctga atttttaagg ctaacttctt 91020 tgtgtctgag taaactgaag tcaaataatg aagtcccaag tgaatcaatt aatggtgatt 91080 ttacctcatt attttcagga atgaacttaa catatacgtt tctgttcttt tatttaattt 91140 aaaattttgt cttgggtaga atcatcttgt ctcattttga ggacaaacaa gtacaaaaag 91200 cctccttggg aattatggga actgaaaaat gctgtgataa ttgcaggtcc aggtaaagat 91260 ttcttattat agatggacat tctaaaagtc tttctttctc ttccttttca tgtttaactg 91320 aatttttgtt gaatgataag tatttcagtt ttttaaacaa aacaatgaat gtgtttagat 91380 atgagaaagc aaacaatatt aaagtatttt gcttaaaaaa tagataaagc aataaaatgg 91440 tagccctaaa tctaaacata tcaatagtta tgttaaatgt aaatgatcta aaatattatt 91500 taaaggcgta aattgtaaga attggtttaa aaacatgacc ctgttctgta cgttgtccac 91560 aagaaatcca ctgtaattat atagataggt ttaaaaaaga atgaaacatt acattccatg 91620 aaaacattaa tcaaaaggaa gttggagtta ctttaatatc agacaatgga cactttggag 91680 caaagaatat tatcaggata aagaaggata ttatatgatg taaaagaatc atttcaccaa 91740 tgtatcagtc agggttcacc agagaaatag gacgattgat attatggaga tatatatata 91800 tatatatata tatatatata tggggaggga aaggaagaac aaatatgggg agagagggat 91860 gaggcgactg attttgaaga attagctcac gaaattgtgg gggttggcaa gtctgaaatt 91920 tgtagagcag gtcaataggc tggaaactca ggcaagaggt gatgttgcag tcttgaggca 91980 gaatttcttc tctagcaaac ctagtttttg ccctttagtc ctgccactga gtggatgagg 92040 cccacccaca ttattgacaa taatctcctt tacttaaagt caactgatta taaatgttaa 92100 tcacgtctac aaaatatttt acagcaacat ctagattagt gtttgaccaa acaactgagc 92160 atcataggct agccaagttg atgcataata ttaatcatca caaccaagaa gacatcatcc 92220 taaatatata tatatatata tatatatata tctacttaac aaaaagactg acagaactga 92280 aaggagaaat agagaaatct acagttacat ttggtgactt ccagcatctc tcaataatca 92340 ataaaactga cagaccaaaa aatcagtaag aagacagaag aaatgaacag gattatcagc 92400 atgctggatc tcattgacct ttttagaaca ttctacccaa caacagtaga gtacacattc 92460 aagtgcagat gcagtattca tgaacatgga tcatattcag agtcataaaa caaaccttaa 92520 caaatttaag aatcttgtat ttgtatattt tttgactaga atggaattaa actagaaaac 92580 aataacagaa agataacaga aaagtctcta aaccttagaa attaaataac acacttataa 92640 ataaatccat gagtcaaaga ggaagtctca aggcaaatca gaaaatgttt tgaactgaat 92700 gaaatgaaaa tacaaaatgt gtgagatgca gctaatgcaa tactgagaag gaaatttata 92760 gcattaaata cctatgtaat aaaagaagaa aggtctcaaa tcagtaccta agcttacatc 92820 ttaagcaaca agcaaataag agcaaaataa atcaaaatga agtaaacata aggaaataac 92880 aaagaacata agtcaatgaa tagaaaagct atggtcatac cactgctgtc cagcctgggt 92940 gacagagtga gaccctatgt caaaaaaatt taaaaacaaa gcagcatgca gcattcattg 93000 tcagtgaata gaaaatggga aaacaataga gaaaatcaac tcaaaagctc attctgtata 93060 aagatcaaca aaattgatat aaacttctaa caagactgac ggaaagagaa aagacacaga 93120 agaccaatac caggaatgaa agagggaatt tcactacaga cctcccaggt attactaggg 93180 atgataaggg aacactatga acaactcaga acataacttt aataatttag atgaaatgga 93240 tcaatttctt gataatctca agctaattaa acttacagtg aattagataa cctgcatagt 93300 gttacaacca ttagagggat tgaattctat gttaaaaatc tctgaaaata aaatccccta 93360 gcccaaagaa tttcaatgac aaattctacc aaacatttag aagacaaaat aataccaatt 93420 ctatagcatg attccattta tataatagtc tttgaaacat aaaactatac tagagggatg 93480 aagaaaagat cagtggttat tagagattgg gggagggaga aggtatgatt ccaaaggata 93540 gtacaaggca gtattttgga gtgatagatt tatcgtgccc tgattgtgat gggagttaga 93600 tgaatctatg gatatcttaa aatgtgtaga actttacaca tacatacaac caatttgcct 93660 atgttaattg aaaaaataaa ataaaaacaa attatttacc tggtgggtta gctacgtacc 93720 taagttcaat agctgcgtta ctgtaagaca aaagaagcat tattagggat ggagttgttc 93780 tctgtgtaat gacaaatact tcttcactaa gaagacagaa ttgttttatg cacctttaaa 93840 aaaaaacaaa aacaaaaaaa atacaaccaa caaacagtaa cttgctggtg cggtggctca 93900 cacttgtagt attagcactt tgggaggctg aggtgggagg atcacttgag accaggattt 93960 ttaagaccag tctgggcaaa aaaccgagac tgtgtctcta caaaaataaa aaataaataa 94020 aaaaaattag ctaggcatag cattatgtgc ctctagtccc agctactctg gaggctaagg 94080 tggaaagatc gcttgagcct ggaaggttga gactgcagtt gcagtgagcc atgatggcac 94140 cactacactc caggctgggc atcagagtaa gactctgtct cacataaaaa aaataataat 94200 aatgataaaa actagtctgg gcatggtggc tcacacctgt agtcccagtc ctttggaagg 94260 ccgaggcaag agaattgctt gaacccaaga ctttgagaac agcctgggca acatagcaag 94320 accccatctc tatttaaaaa aaaaaacaaa cttaaaaatc cagcaaatac ataaagcaca 94380 aagccgacag aagaggtgga gaaatcaaca aatccaccat caaagtggga gaatttgata 94440 taattttaag ttattggtag ggtaaacaat ccaaaaatta gtacactgta gaaaatttgg 94500 tcaacatagt aataagtttg cttattacta tttatcagta tacatagtat actgatttat 94560 cagatacata gtatatggag ccctagagca agcaactata gcagtgtatc tcaagtattt 94620 ttacttcatg acccacatag caaatgatat gtgtatataa cacactgggc taattgtcag 94680 agttcagttt ctgtccaaaa ccctaagatc tggagtgatt aacctttcag cactcttaga 94740 actcacttgt ttgtagcaca ctgattgaga agcactgaaa gacttcactc ctcaaacata 94800 catggaatat ttctaaaaac tatgtattgg gccgggtgca gtggctcatg cctgtaatcc 94860 cagcactttg ggaggccgag gcgggtggat cccgaggtca ggagatcgag accatcctgg 94920 ctaacatgat gaaacgccgt ctctactaaa aatacaaaaa attagccgga tgtggtggcg 94980 agtgcctgta gtcccagcta ctcgggaggc tgaggcagga gaatggtgtg aacccaggag 95040 gcggagcttg cagtgagccg agatcgcgcc actgcactcc agcctgggca acagagcgag 95100 actctgtctc aaaaaaaacc aaccaactga acaaacaaaa aaactaaaaa acaaaaacaa 95160 aaaaactatg tattagagca tgggttggca aactatggcc tgtaggccaa atctgcatgc 95220 tgttttattt ttttttattt ttttgacata gggtcactac aggctgtcac acaggctgga 95280 gagcagtggt atgatcatag ctcactgtaa cctcaaattc ctgggctcaa gcaattctct 95340 tgcctcacct cagcttccca agtagctaca ggcatgcact accagaccca gttaattaaa 95400 acaaattttt ttttggtaga gacagtctca gtatgttgcc caggctggtt ttcaaactcc 95460 ttgcctcaat cagtcctcct acttcagcct cctaaagtgc tgggattata ggcatgagcc 95520 atcacgcttg actaatgttt ttgtaaataa agttttctca gaacacagcc atgccttttg 95580 tttatgtgtt atgtagggct gcctgagtta agtagttggc tgcaaagcct atcatggcct 95640 ataaagcctg aaatacttac tatctggtcc tttatagaaa gtgttttctg accctgtact 95700 agactagctt gtctcaaaat tcttcaatga atttggaagt tttctcacca cattttctga 95760 ccataatgca cttgagttag aagtaaataa gcagataaac aacaaaatcc tcatgcattt 95820 ggaaattaaa aataacactt aaataattca tattcaaaga aaaaatcaaa ctggaaatta 95880 aaaaaaattt taaacctaca gataactaca ttaatatgca ttaacatttt tagaacttag 95940 ggatagttac aatgatatac attaaaactg gtaagaggct gggtgcgttg gctcacgcct 96000 gtaatcccag cactttggga ggccgaggct gggggatcac gaggtcaaga gattgaaacc 96060 atcctggcca acatggtgaa accccgtctc tactaaaaat acaaaaatca gctgggcgtg 96120 gtggcacgcg cctgtagtcc cagctacttg ggaggctgag gcaggagaat cgcttgaacc 96180 tgggaggcgg aggttgccgt gagccgagat tgggccactg cactccagcc tggcgacaga 96240 gcgacactct tgtctcaaaa aaaaaacaaa acaaaacaaa aaaaaaaact agtaagaggg 96300 cccagtggct cacacctgtc attctagctc tttgggagac tgaggagaga ggatcagttg 96360 aggccaggat tcaagaccag tctgggcaac ataacgagac cgcatctcta caaaatttta 96420 ataacaacaa caaaaaaaac tggtaagagg caacattgaa tagtactttg tgggagttta 96480 ttagcttgaa atactcataa tagaaaagaa aattaatcag ctaagcatct cactaaagag 96540 attaggagaa taaacctaag catagttttt ttcccccaaa cattattata tctggaatat 96600 tgaatgcatt cttattgcta tttcaaagat acttactcta aggaaagcaa ttgaattagg 96660 tagttgaact ctatagtaga ttttctttaa tgagtccttt tgttctcaac ctacttaaat 96720 aattctcatt tgaatttatg atagtttcag atctacccaa agggtgactt aggaatttaa 96780 cttctaaatc tatttaaatg aaaggtttat aatctttttg tcatatttta cagtcgttag 96840 cgtttaacaa tttatagcat aggatttggg tttttttttt tttttcattt taaagaagaa 96900 gtttatttaa gcaagacact tgactaaggg aagactatct tggagttatt attactagag 96960 taatttattt ctacttaaag acagattgcc ccacaagtaa cagctacata aaaacagttg 97020 taaaattgtc cttggtttta caatgataaa tgaaaaacat taaaattctc taattgaaca 97080 aggtatgcaa ggatttttat attgtttttt gctaaaacta tgacagcaaa ataacatcct 97140 ggagtataaa gataagagct gaatgagcag gccactaggg gacaaaggga gtcttttcac 97200 agaaccaatg cttcttttgc ccaccccatc tccatcgaag tcaatctaaa catattattg 97260 gccatttagt taaaaaaaga aagaaaagaa aagcaatatg cttgtggaca tacaccagtt 97320 actttatgtg cagtaaaaga gtaggaaggg gaaggtgaaa gaatagagaa aactatgtag 97380 tcaggatgtg gtggaaccaa attgcaactt tctttttttt tgagacagag ttttgctctt 97440 gtcacccagg ctggagtgta gtggtggccc aatcttggct cactgcaacc tccgcctctc 97500 agattcaagc cattctcctg cctcagcctt ctgagtagct gggattacag gtgcatgcca 97560 ccatgcctgg ctaatttttg tatttttagt agagatgggt tttcaccatg ttggccaggc 97620 tggtcttgaa tgcctgactt caagtgatcc acccgcctca gcctcccaaa gtgctgggat 97680 tacaggcgtg agccactgcg cctggccaaa ttgtagcttt ctaattgaga ctgtcttctt 97740 ggtctggaag agcagagttc tgcagtaaaa taacaggtcc cccttttagt agacatctcc 97800 atgtctgctg ctggaacaca tcagttttgt cttaagcctc acttccaaat gtgcagatgt 97860 gtctggttca ttgattggct gcctgtcaaa ttgaaacctg atctgcctca ttggcaaacc 97920 gtgcccctta caataggctt tcattggttt actaagcggt gtggtgcgtg gctgttcatc 97980 ttaaactgca ccacagttta agatgaacct tcaaatgaac attatccttg ttctcagtct 98040 tgactttcct tgggcttttt gtggaccctg gtgagtgtgg cagtctcctc agctgctgct 98100 tcacaaaaga ggtaccaggt ctgccccgaa tgagtgagcc cctaaacagg accaggagtg 98160 gcagaagaaa gaggcagcaa ctgagatgtg ttttttctaa gctgaaaggc tttttttttt 98220 tttttttttg caacacacct ttaacactaa agtccaatat ttatataatt ggtcaagtaa 98280 gtggagctgt tctagctata aatatggcaa ctctgcttgc tcgtcctatt attgacatta 98340 ttcctttctg tggtctgagg tgcctcccat gaaacttgct tctaggacac taggattgag 98400 aaccatcagc gtaacatatc tgttacgcta caatagttta ttttcatatt ttagctactt 98460 tacatactcg ggtataatga actttattca tagcttctga agcagttggc acatttgaga 98520 tattttttac ttggctaatt gttatgctaa atcttttgat ttctaaagat acatgccttt 98580 gctaagcttt cttcaaatgt tattattttt atttagattg gatcattgct attccatgga 98640 tgactcagag gatacatcct gggactttgg tccacaagca tttaagcttt tgtctgctgt 98700 ggacatctta ggcgaaaaat ttggaattgg gcttccaatt ttatttctcc gaggatctgt 98760 aagtatatat ctgtgaattc ccttcataga tcttctttta cttctattac acttttcttc 98820 agaggtttgc agtattatga ttgtagcttt gacttcagat gggtgactag gaactcatag 98880 agtcttacta agttccagtt aaacactaca ttcattactt tggataaaac ccgtgtgtat 98940 ggcatcttct gctgttttca tgttcaagcc gatgttcagc tctgcagctc agtctggaag 99000 cattgtgtta atttatcaca ttgcatttgg gtgaatccct agactagtct tgcttaggat 99060 aattaggaaa agttaacttt cattgtatca agggacaggt agaacaaaat tgtccttttg 99120 tccaggaaac cattaaattc ttcaaggaaa actttagtta tagggattat tttttaaatg 99180 tctaatttca gtaacaatat ttgggacata tttatttttc cttctgtttc ctatcagaag 99240 tatttaaagt tataagaaaa ttgtggtttt tgcctttact aatgaataaa taatcaatta 99300 aattcagtta cttttttttg gagtgattga tgttccagta ttcttctaaa caaccacggg 99360 tacaaatgtg aataagatag gaccgttgca gtccaagagc ttgttctgta gtcctttcct 99420 ttatatgatt ttttcccctg atttagaagt ctataaagca aagctaagta ttacacactg 99480 ataatggctg aataaatcaa gagcaagaga taggatactt tgcaaatatg catatttatt 99540 aaaaatgtac tttaaaatag agattaaaat tctcgtattg aatgtagaat aggtaagcat 99600 ttatttgtga aatactcgaa tgcttcatgt aaatactttc tgagtttgta tttttagaaa 99660 ggaacatttt ggaggctgag gcaggagaat ggcgtgaacg tgggaggcgg agcttgcagt 99720 gagctgagat tgtgccactg cactccagcc tgcgcgacag agcaagattc tgtctcaata 99780 aaaaaaaaaa aagaaacata tttattaaat tagttgtgaa atatttttaa tgaaatatat 99840 tgaaaacttc tgttgatttt tcatgtactg atgtttttag attctaaatg gagtttaaaa 99900 ttttgtttgt aaatcacaag ttggattaga aatttaatag tagaagtgtt gcctaaggac 99960 tattttaggt gctgtgagtg aaactgtatt ttttataaca agaattttag ttgtaaggga 100020 cagcttaaat ataattgaga tctgtgaaaa tgtattctgt ctctatcacc ttcagaacct 100080 gtgtatctca gttgaatgta taatttataa aaattattct tgttttaatt tggtgtaatc 100140 cagccatatc cagtatcaac aaataagtct aagtaggctc cttgacaaac ttgaactggc 100200 cacaagagag atcagatttc acctattaaa aaaccaaatc agaccactta cactgacagt 100260 ctcttctggg agtcctcaaa ttaagaagtc tatcctttgt gaaatattac actacccttg 100320 ctagataaaa cttttctaaa agtaccactt aatgaaaatc tgtagacact aaatgcaatg 100380 aaaataaggc attgtttttt tttctcccca tttcagtgat cttggtatcc tgggatattg 100440 tttttaaaat tatcgttata attcctttga gaatttagtg aaatgttccc tttaaccaac 100500 ttaggaaaaa ttaatatctt tgtacatgat tttgagctgt aaaataaaca ttttaaactg 100560 ggaataattg gagtttagtt aaagagataa tgtatataaa tatataacat agtagcagca 100620 tataattctg tcttacacaa gatttttctg aatagtataa acagttatgt agcctatcta 100680 ggagtttgtg aatagagttt aaaattttgt tttgaagctg caaatttgat tagaaattaa 100740 acagtgaagt tattacttaa ggaacttcgt tttagctgtc tgaacaactt actgtataaa 100800 aatctttaaa cattctgtat aaatatgtga taagatatgc aatgacctta attttataga 100860 ttagaaaata aaaacacact cattaattta cataactgac agattaagtg aaacttctct 100920 tctgatcacg ttagcagaat gccaaatctt gtcgtggcac tagaattaga cggtagtttt 100980 gataatacat gatttgacta tagacatttg ttgaaactat tggtagtttt aatcactctt 101040 gtaattttca aactatctaa cgggagagga ttatccatcc tgttttctag acaaactgtt 101100 tcatctgaat gaaatatatt cctagagata attatcacta cttcatcttt tggttttatt 101160 ttgcacatag aattatagtt cacaatgact ttctgaagct ctaaagttgc agctgtgagc 101220 ttctttggcc tgtagggact gggaaaaagc acccccgtcc tcccccaagc ccccccacca 101280 aaaaaagtta aagtgttttt aacaatagct gtgggctttt tgtagtttca gaacttagga 101340 gttgcccagg ctggaatgca gtggtgtgat catagcttga tgcagccttg aactcctggg 101400 ttcaagcaat cctcccacct cagcctccag agtagctggg accacaggtg ccaccccacc 101460 cagctatttt ttttattttt taattttttt gtaggtatgg ggtctcccca tgttgccctg 101520 cctgtctcaa actccagggc tctcaggtga tacccaccac ccttggcctc ccaaagcacc 101580 gagagtcact gtgccaggct gagtttaaaa tttcttgagt tggagtttat ggctattttt 101640 tccactagtt attaaacatg tatttttgta taaggcactg tattacattt tgtgggggga 101700 ttcaaagcta aattagatga gacgcatcat ctattatgga agatgttact taagaagaaa 101760 tgagtgtaat gtagcagaga attagataag ggacgtatga atacatataa atgctgttga 101820 agttctgaag agagagagtg tttagagaaa ttagaggagt ctttgtgaag gtatcactag 101880 aacttcctat ttttgtggaa tatatagtag attttggtgt gatactgtgg atttggacat 101940 tcactcagag aaggaatgag ggaagaatgg tggagaagaa tggcattcac agtacaaaaa 102000 gcaactgtga cttttaaaga agttaatatg gagaagtggc aagtcttttc ttctctcttc 102060 tcttctcttc tctcttcttt ttcttttttc tttttttctc tgtcagatac cgttgtaaag 102120 actttgcttt taccggaaac tgatacgttg ggtcatgtac cctggccagt cagttctctt 102180 tattctaaca cttagccgat cagttagatt tccacattcc atgatatgtc agttttggtg 102240 acccttattt ttccacctgg tttataaagg gaaagaatgt gatatgtcac ccaggctctg 102300 gagtacagtg gcatgatcat aggtcacagc agcctcaaag tttccagttc aagcgatcct 102360 acttccttgg cttcctgagt atgtggcact acaggtgcat gccaccatgc ccagctaact 102420 tttttgtaga gacagggtct ccctatgttt cccaggctgg tcttgaaccc ctgacctcaa 102480 gtgatccgcc caccttggct tcccaagata ttggcattac aggcatgagc cactgtgccg 102540 gcctgaaaat ttctcttttg agatggcatc ccacagaagt atacctgctt agagctaaca 102600 ctggtaaaaa gactatttaa ccctattgcc ttattttact gtagttgaga ttgagttaaa 102660 ctgaaagctg aatgacctgt cctaggtcat actgttactt tgtgccagag tcaggatgag 102720 caaatggatt tcctgcctgc tagtctagtg tcttttctat ttattgtgct gtaacataca 102780 gttttaaatt tgtattttta tgcccaatgg acatggtagc tcacacctgt aatttcagca 102840 cttttgggaa gccgaggtgg ggggattgct cgagaccagg agttcaagat gagcctgggc 102900 aacatagcga gactccgtct ctataaaaaa aaatttaaaa attagctgag tggtgatgtg 102960 tgtgcgtgta gtcctccttg tgggaggttg aggtgggagg atcgattgaa tctaggaatt 103020 caggactgca gtgagccatg attacaccac tgcactccag cctgggtgac agagcaatac 103080 cctgtctcga atgaatgaat gaatgaatga atgaatgaat gaatgcccaa atccgtaagc 103140 tatgttctgt atagcagctt tttcatcata ggcagttttt actcttatca gtggacaacc 103200 tacaaaatta actaaacact taaacaatta acagaggagg ccttgttcag agtgagaaat 103260 cattaagcat ttgttgttga aatttcttac tgtactctgt tttaattctg tttttttttt 103320 tttttaatgt tacttgtttt agtttggatt cctagttgaa aagggaatat gattccttta 103380 aaacaaagat actctgcttt aaagcaaagg tatatcatcc tcttcatggt gattgccatg 103440 gaaacaagac aatgtaaatt tattcaaata gtacacagtt tttatagtta ttgatcatga 103500 ggggaaggga cagttaatcc ctactgatca gataaaacct cattgtttca tactaataaa 103560 tggttttttt atgcttatga aaggaaaagc cagaagtgta atttttagtg tttagagagc 103620 tagtgattct agttagggaa cttaatacct ttgaagttat tagtttgcaa gcaatagaat 103680 ctactactac caaggtgacc cctagcagat gtagagtacc attaacaagt gttccaggga 103740 aggaaagcca actagatacc aagtcatgct ttttactctt agattaagaa attcaggttg 103800 agttaaagga tcagctgtta actaataaaa agcagattaa tattacagag ccaggctctg 103860 tcctggttat ggacttaatc ttcacagcat cctcaagaga taaaaatgaa tatacctgca 103920 tattagatga ggaaatagaa gataagtaac ttgccagagc tatgacgtga actcaggtaa 103980 tgtagcttaa gagcccccac atgtatgtat attgggtgtg tgtgtggagg gggtgcgtgt 104040 gagtgcttgt gcatgcgtgt ggtataataa gaaaaaatta gcatttatgc ctgtaatccc 104100 agcactttgg gagaccgagg cacgaggatc tctcaacccc aggagttcaa gaccagtcta 104160 ggcaacatag cgagacccta cctctacaaa aaaagtttta aaaatattag cgggcatggt 104220 ggaatacacc tgtagtctca gctgcttggg acgctgaggt gggaggatcc ttgagtccag 104280 gagattgagg ctacagtgag ctatgatgac acctctgcac tccagcttgg gtgacaaaga 104340 gagaccctgt ctccaaaaaa aaaaattaga actagttatc tggaggcctg tgttctagtc 104400 ctagctttag tacggctaca cagtgacaca ttaggctacc atttaacatc tttgaacctc 104460 tgataatttg ttaacaatat gggtaaaaat gactaagata aatcaaagag ctccagcatt 104520 ccctccagct ctgaaattct atgatgtttt atcttatttt acttacaaaa ataaattata 104580 ttatgtatat ttaaagtata caatttgatg ttatgggtta cctatagtaa aatgattact 104640 ataatgaaac taattaacat atccatcatc ttatattgtt aaccattttt ttgtttttgt 104700 ggcaaaagca gctgaaatcc actcatttag caggaatccc aaatacagtt cagttgtatt 104760 aattgtaatt ctcatgttgt acattcgatc tctagacttg tttatgctac atatgtttga 104820 cttttaaaca ttctactcaa atcaacccta agtcagggtt agcacagaca ggacttgtta 104880 acaaggtaga aggtgccaca ttgtacctgg gtgtttatat ttctctaaat cttgttctga 104940 tcatatttta ataaatataa tcatcaggac accaaaattc attccttagc tattaaaaaa 105000 ttctattcta ttttattgtt aagatttagg agagcatggt acagattctc ttaactatac 105060 ctatcagaag cctatgtttt aagtccaatg tataggcact gctctgtttg tctctggtgg 105120 gaacttaccc tgctttacct aatttcatcc tagcttcctt tttgtgaaag atcacccttg 105180 cttagcctat tttttggcaa atctacacct tggaaatagt agtaaatgac ataagcatat 105240 taatatttat gatgtgattt atttttgttt tcaagtcata tactggggaa gattctcaaa 105300 tattaaaaca atgtatcttt acatttatgt atgtcgttct tgttctgttt tagaaggctt 105360 gtatttgcat ttttaacatt ccaaaaggta aacctgtaat cataatgttt tcatcaattc 105420 aataaaacca ttacgtttgt aatagagagc cctatagttg ccttagttaa gtttgctgca 105480 actcatttta tatattcttt taattttgat ccctggattt ttaattgatt attaaacctt 105540 cattaggata tatatgaaat gtaaaaatat tgagttataa tctaccgttt tctaaaattt 105600 tatactgcat ttttatatag aaattcaaat tgctcataat cattctagtg aatttaagta 105660 gaaaggtatt tattactagg tattaaatgg cttataatat tgttgacaag gttccactgc 105720 aaaatagttc accaagggag ctgtggcctc ttctgtgatc aagaagccat ctgtcaactt 105780 gggaagcttc cactatagca cctaacccca gactacattg agtaggaagc tgtaataatc 105840 aggaagcttc tacctttgca tgctctgcaa accaacgtga acctgctgta atttgtaacc 105900 acaaaatgga tgcctgttga tacttacgaa gctcatcatt gtatgctggg ttctttgcta 105960 atactttctt ataaaaatta aatacctcca caatcatgca tgctagcaga aacagcagag 106020 gagtagcctt agcctcactt cctgcttata cctgtcatgc aaatatacag aacccagaac 106080 cctagctgaa agggagtttg agaactagta tttgtattgt cccagattct gcagtggaag 106140 aattcatagt ggatggaagt tagaatgacc cttgaattac aatcggccac attcatcaca 106200 aatacattaa ataagagtaa tttgccataa agctctatgt ttgtatactt ctttgttttt 106260 tttttttttt tttttttttt tttttgagac agggtctcac tctgttgctc agtctgtagt 106320 gcagtggtgt catcatagct cactgcagtc ttgatctcct gagctcaaac gattctcctg 106380 cctcagctcc tgcttcagcc tcctgagtag cggaacaaca ggtacacacc accacacttt 106440 gctaattttt tattttttat tttttgtaga gatgtgggtc tcactgtgtt gcccaggatg 106500 gtctcgaact cctgggctta agtgatcctc ccaaagtgtt gggattacag gcatgaacca 106560 ctgtgcctgg cccatatact acatatattt aaaagtagta tttaaatgtg taggatgaat 106620 gaaagaggca gtaagagaac aaagtgaatg aaaaagtatt tctatatgaa gtgaaagcag 106680 gagagtcctc tctgttagag aacaacagaa ttgcatatga cagactagct ttcttaatat 106740 ttctagaact tgatggctgt gaagagcgtc ccgtaggaat tctcccttca cttaggaaaa 106800 catacctcaa aaccatcagc tgtttagcat gcacctgctt ttcctggtat atctcagtga 106860 agcagctaaa ttgtaaatga ttaagtaaac tttgcagtgt atcatgtgca aaagcacagt 106920 aaaaacaaaa atgcattgga agctgtgagt tgttgcactg cactcatgga tgaatagctg 106980 ttggttcgca ttgcgttttt ttgttttgtt ttgttttgtt tttttgagat ggagtcttgc 107040 tctgttgccc aggctggagt gcagtggcgt gatctcggct cactgcaagc tctgcctccc 107100 agattcacgc catcctcctg cctcagcctc ccgagcagct gggaccacag gtgcccgcca 107160 caacacctgg ctaatttttt gtatttttag tagagacggg gtttcaccat gttagccatg 107220 atggtctcaa tctcctgacc tcgtgatctg cctgccttgg cctcccaaag tgctaggatt 107280 acaggcatgc cgcattgcgt tttatataat tctcatggtt ctagtctcga gctgtaggat 107340 tttgatcact gtttcaaaca ataatgtgag tttgctaaga ggtctaaata acaaaagcta 107400 agtgttccaa acacatatcc aaacctatac actgggcaat gcatctgaat tatatgtgaa 107460 atttcctgcc attatttaag acacaaaagg aacattattt tgataatgta tttatttgtg 107520 agtggagtgt tcagaatgag cacgatgggt ataacatttt tgtaggtttt taaagttgaa 107580 atttagtgta aatccaaaga atcaatagac aagtctgtgt tttacttaac ctatatgttt 107640 aaattagcat ttttagatac tgattttatt cctaatttca gaattctcag cgtcttgccg 107700 atcaatatcg caggcacagt ttatttggca ctggcaagga tcaaacagag agttggtgga 107760 aggctttttc ccgtcagctg atcactgagg gattcttggt agaagtttct cggtataaca 107820 aatttatgaa gatttgcgcc cttacgaaaa aggtaaacgg tgtaggagtc tgcctgtttg 107880 acttaatttt gtttcccact ccacattaaa agatcctttt tgcttttaat agggtagaaa 107940 ttggcttcat aaagctaata cagaatctca gagcctcatc cttcaagcta atgaagaatt 108000 gtgtccaaag aagttgcttc tgcctagttt catttttcag tttttttctt gtaacttctg 108060 cattttttgt tgctatttat gtgattcaaa ttataccagt ttataggcct ctcacaagta 108120 aaatgaatta cctgtttgtt tttgtatgcc tattttagtc agtttggggg aagggatctg 108180 tgaggaaagg ataagtcata gagcactttt cttttttaag agacagagtc tctctgtgtt 108240 gctcaagctg gagtgcagtg gtgcgatcat agcttactgc agcctcgatc tcgtgggccc 108300 aagtaatcct cagccacctg agtagatggg actacagaca tgcactacta tgcccagcta 108360 atatatttta attttttgta tagagacagg gtcttctagt gcttcctagg ctggtcttga 108420 actcctgagc tcaagtgatc ctcctgcctc agcctcccaa actactggga ttacaggcat 108480 gatccaccgc tcccagccag aacattttct tggttgatgg gaagtagctg accatggtat 108540 ttagaaaact tctttctcat cgattaaaga agcagtactg aaatcaatgc ggaggaatcc 108600 atatatcata tttacttctg gtgtgtagaa gtggaaaggg aatacatttg ttgcttactt 108660 ttttgtacct ttacatgtga ttgatcactt gtgagttttt tctttcaaac atcttaaagc 108720 ttccagagct ttttctagaa aaaaaaatca gttttaagaa tcaccagttc taaaagggta 108780 atatcttatt catctttctg agaatggagt atcatgattc atgaattaga tacttgcatc 108840 ttaacatttg aaataattta attttattat tttttagttc gaaaactgta tcttcgggca 108900 ccaaagagca ttgttataat caagtaccag ttgaattaag tacagagaag aaggtttgtt 108960 ttaaagaaat tgttctgatt tatttcattc tttattgatt caaattctgt ttaaaatttt 109020 atattttaat tcctttccaa ttaaagagaa aatggcatat ataacaaagc ataaaattcg 109080 gccagggaag tgatgtgaac agactaaaat ttattgtata taatttctgg ggctaataaa 109140 gaattggagg tatttgagaa aggaattaat ttgggttctt ttaaacctat ctgctaactc 109200 atttggctta gagtagtcac atgttataat acttatagtt gatcaaaaaa ttgattccta 109260 agtgttctta ttaaagacac acacacacac acacacacac acacacattc tctctctctc 109320 tctctcacac acacacacat gcacacacac ttatgtactt tcttgctttt tttgacctaa 109380 gatcttagat aactattaca gattaaatac taatccactg gcagacttca gctaattaga 109440 acactggaat aataggcaag catagtgaat tacattttct ggtgaacttt ttctgcttta 109500 ttgaagtatg cagaatgtaa atgaattgtt tttataactt tggcacttgc tgtatcttag 109560 aacattcttt tgatgattta ttttctgtag ttttgggaga gataagacat tggaatgcgt 109620 ttctaactac ctttagaact ttagaaactg ataatttagg aggttatttt caggtgatta 109680 atttgacagc ttgattaggc aaagaaaaaa ttgtgatttt gagatttttg tttcttattt 109740 tcttcacatt taaaagtttt ttgaaacttt ttttaatgga cctttatatg tttaaatgca 109800 gtctaacttg gagaagttat attcttataa accatgtgat aagatttctt ctgggagtaa 109860 catttctaaa aaaaggtaca gagttccata tttctatgtt ctatacttgc tttatgagta 109920 cttttttttc taaagagaaa gaactgtcag atgttgggct atttcattgg caaaaggaag 109980 ttaaatttaa aacataagct tttcagtatt agaatgatca aagtgagcta taaaagaata 110040 atgttaattt aatagctaac acttcttgga tattactgtt tgtcaggcat tatgttaaat 110100 gctaagaact ttatatgtga tatctcattt aattcttaca agagtctaac agctgttact 110160 atttatcgcc attttatagt tgaagatacc aagggttaag aagttgacaa acttgttcaa 110220 gagcatacag ctaatggccg agctggcttt caagtctata tttgtctacc tctagcatca 110280 agacactatt tatttttctt tgtatgaaat atatacaggc atactttgtt ttattgtgcc 110340 tggctttatt gtgacttgca gatattgcat ttcttataaa ttgaaggttt gtggcaaccc 110400 tgcgtcaaac aggtcatatt agccccattt tccaatagca tgttctgttg tcatgtcttt 110460 gtgttatatt ttggtagttc ttgactggcc attcaccatt tctctccctc tcctcgggtc 110520 tccctgttcc ctgagataca acaaaattga aattaggcca attaataact ctataatagt 110580 ctctaagtgt gttttttttt ttttcgagac tgagtctcac tctgttgttc aggctggagt 110640 gcagtagcac aatctcggct cactgcaatc ttcgcctccc gggttcaagc gattctcctg 110700 tcttagcctc ctgagtagct gggactacag gcgccccccg atcatgtctg gctaattttt 110760 gtatttttag tagagatggg tttttgccgt gttggtcagg tggatcttga actcctgaac 110820 tcaggtgatc cgcctgcctt ggcctcccaa agtgctggga ttacaggtgt gagccgctgt 110880 gcctggccca tctctaagtg tttaagagaa aggaagattc acatgtctct caatttaaat 110940 caaaagctaa aagtgattag gcttagtgag gaagccatgt cgaaagctga gataggccaa 111000 aagctaggcc ccttgcacca aacagttagt ttgcaaaggc aaaagttcct gaaggaaatt 111060 aaaaatgcta ccccagtgaa taaaacaatg ataagaaagc aaagcaggct ttttgctgat 111120 atggagaaag ttttagtggt ctttatagga gattaaacca gccacaacat tcccttgagc 111180 caaagcctaa tccagagcaa agccctaact ctcttcaatt ctctgaaagc tgagagaggt 111240 gaggaagctg cagaataaaa gtttgaggcc agcagaggtt ggttcatgag gtttaaggaa 111300 agaagccatc tccataacat aaaagtgcaa agtgaaacag caagtgctgg tatagaagct 111360 gtagcaagtt atccagaaga tctagctaag atcatcgatg aaggtgcctg cactaacaga 111420 ctttgaatgt agaccaaatg ctttctacca gaagaagaag ctgtctagta ctttcatagc 111480 tagagagaag tcaatgcctg gcttcaaagc ttcaaaggac aagctgactc tcttgttaga 111540 agctgatgca gctggtgact ttaagttgaa gccagtgctc aattagcatt ctgaaaatcc 111600 tagggccctt aagaattatg ctatatctac tctgcctttg ctacatacat gtaacaacaa 111660 agtcttgatg atacctgttt acagcatggt ttcctgaata ctttaagccc attgttgaaa 111720 cctgcttaga caaaagattc ctttcaaaat gttattgctc attgacaaca cttagtcacc 111780 aagagccgta atggagacat acaaggagac taacgttgtt ttcatgcctg ctcgcttaac 111840 atccattctg tagctcatgg atcaagaagt aaattaacct tttaagtatt attatttaag 111900 aaatacagtt tgtaatgctt tagcttctgt agatagtgat tatcagagat gggtttttaa 111960 gaggttttcc agaaaacctt ctggaaaata ttcactattc tagaagtcat gaagaatatt 112020 tgtgattcag gagagtaggt cagaatatca atattaatag gaatttggaa gaagtcgatt 112080 cttattaaaa tcaagagttt agtgatagac atactgagtt tgggatacct gtggagtagt 112140 ccagaagtta atttaaatat atgggcttag tgtacagaag tgagcagggt gcttatatat 112200 gaataaatat tattttaaga tatatttaaa ttttccttaa aataatacct atacttgata 112260 taaaaagtta attggaaatt agtggcttat gacaagcata ccagcccaca ctcttcccaa 112320 acccactttg ctcttattca tagaagctgt catcttcaaa tcttccagct gatttccctg 112380 gcgtgtgcct tcttatttct gaatgacacg cttagagtac tatttttttg acttagcaat 112440 tttagaaatt ttctactcat ctcctattat ggtagatttc ccctccttca ttcctcctcc 112500 aatataatta tatttcgtca tattaataat ttgtttatat atatttttaa tataatatga 112560 taatattgta tttatattat taaaactaca caaatattat atacacacta ctaacccaac 112620 cgtgttatta tggccaccac tacctttatt tttttccttg tgttagtgat tgtctttgtt 112680 ttattttctt ggttttgagt attcctttta ctaattttct tttttcctat ttcaatctct 112740 cattatttgt ttactcattt ggagtgttcc ttgactttta tcccctctta cctagtgaca 112800 ttttaatttt agttatcaaa tttttaattt ctaagaatgc ttcttgttct cttcttgttt 112860 cttcttcccc accagccaaa aatctatgat gttatagcaa ggatcataca ttgtttccca 112920 gtaggttaag aaaccttggt taaaacctgt tgtatcccag taagttaaaa gacgttaacg 112980 tgtcatcttc agtatggatg aaagaatatt ttctttcaaa agcagttggt tgaggaagag 113040 aatgggacaa atgctctttt taaaacacca attttgtgat gaactcaaat tgcaatttta 113100 actttaccat tataatgaat gtatttgatc caaaatgttt aaaatctagg ctgttgtcat 113160 ttaaataaca aattacctta ctggtatcat gaagaataaa tgtttgtact gatttggaaa 113220 gacattctca tttaggggat gaaatagaaa gtcaatgagg agaaagaaaa gcttttatta 113280 tttattttct tttaaatatt ttagtatcat ggtacagtca ccagaaaaag cttacagttc 113340 ctcacagcct gttatttcgg cacaagagca ggagactcag gtaaggcttt tgtaaaaagg 113400 taattagttt atgataggat agttatgatt ctatgtatgc ttaaaattct gtattttgcc 113460 agcattttaa aaattgttct taagctaaga gtctgagttt atatttcagt ttatattcat 113520 tctaaggaaa aatgtggtat ctgaagctct aaaaataaag gactagatct tttaagtaca 113580 ctttaaaaag tgttgtttct ttgttttttg ttcagattgt gttatatggc aaattggtag 113640 aagctaggca gaaacatgcc aataaaatgg atgttccccc agctattctg gcaacaaaca 113700 agatactggt ggatatggcc aaaatgaggt aaactatctt ttgcatgtgt tctatttatt 113760 tccttctaac aaaatagatt tggaaaatat atctaagttg ataatatgac catagcttcc 113820 actgtcacat ctgggaggtg actcagattc cccctgctgc gatgcttatc tctttgccaa 113880 gctttagtac cgtgtttctg tatgaataaa aaccagttac gttttcagca atcatattca 113940 atatttataa aatctaactc attatttacc caccctgcat tttatccaaa tgccgaaact 114000 cctctttttg gattctttat ttttgattat cttaccatca catttgtagt cagaggttcc 114060 taatgcttaa aacctctgat ctgaattttc tctcctccaa tataaaaccc cttcgtcttc 114120 ctcttcttct tcttcatttt tttttttttt tttgtctgaa gacttgtctc actgtgttgc 114180 ccaggctgga gtgtagtggt gcgatcactg ctcactgcag ccttgacccc ctggactcaa 114240 gctatcctcg cacctcagcc tcccgagtag ctgggactac agaacatgcc accatgctca 114300 gctaattttt gtattttttg tagagacagg gttttgccat attgcctagg ctggtcttga 114360 actcctaagc tcaagcaatc ttcccgcctc agtctccaaa gttctggcac tacaggtgtg 114420 agccactgtg cctggcctct ttttctcatt taaatacttt tcataccttt tgtaaaacgg 114480 gttccttgtt gcctgtctat gccttcctcc tccttcttaa tgacaccacg ttaattctga 114540 ctgttttccc ttggcctgtt gcagaagcct cttaactatt aacccttcat tctctctctc 114600 tgtttcatct gatatatgag taccaaacta aatcttcctt tatcatatct tacttctgct 114660 taaatgtttt ttttctagct tagaattcaa ggccctctat ttatgaactt aaacttactt 114720 ttccctctaa gttacagaat ttgaaatggt ttatcttacc tggattgttt atcacttgtt 114780 gaagatccat tttcaacttc catatattta tttacagtgt tgcttctcct tgtagtttcc 114840 ttgattcctc aaaactcctt ttaagaattc ttgaagatct cgctttatta ctatttctcg 114900 ctttattact gtaaagacta tgagaaggtc tttcatgatc ttatcagcaa agtaattcct 114960 ctctcttgaa ttcatagagg actttcagat gaattctaaa gatgcttctg tagcacttac 115020 cacacaatgc tatattttat ttttttgtaa ttagtggtaa acaagtatta ttatatcttc 115080 tagattttaa actccaaata aagatactag ctccttacct ttttgtgtgt ctcctgtagc 115140 acctagcaca atgcctcata aacaggaggt gatcattaaa tatttagaag aaattatttc 115200 ccaagaatag ttgcttggta attgtatttg tcttttactt ccttttaaaa aattgtttct 115260 gtcactaaat tgcatccaat agatgttact tgagtgcaga attttctaat gacattacac 115320 agtgctacat ctgacactaa ttcttttgtt aaaaaataaa tattctggcc gggcgctgtg 115380 gctcacgctt gtaaatccca ggactttggg aggccgaggc gggcggatca cgaggttagg 115440 agatcgaggc catcctggct aacacggtga aaccccgttt ctactaaaaa tacaaaaaat 115500 tagccgggcg tggtggcggg tgcctgtagt cccagttact ctggcggctg aggcaggaga 115560 atggcgtgaa cccgggaggc ggagcttgca gtgagcggag atcgcgccac tgcactccag 115620 cctgggtgac agagcgagac tccgtctaaa aaaaaaataa aaaataaaaa taaataaata 115680 ttctaagacc atactttaat agaggtgttt tttttttttt tttttttttt tttttttttt 115740 tttggtgata gagtctcact ctgtcaccta ggctagagtg cagtggcgcg atctcggctc 115800 actgcaacct ccgcctcctg ggttcaagca attctcctgc ctcagcctcc ggaatagctg 115860 ggactacagg tgcgcgctgc cacccccggc taattttttg tattttagta gagatgaggt 115920 ttcactgtgt tgtccaggct ggtgttgaac tcctgagctc aggcaatcca cccgccccgg 115980 cctcccaaat tgttgggatt acaggcgtga gccacagtgc ctggcccaga ggagatattt 116040 aatgaaaaat aataatcatt agataggcag atttttagaa ggagggcatc gaatgggttc 116100 ttggatattg gacacaataa gaaatattga gctaaaagtc tgaaggaatt ggcagatata 116160 ctgttacagg taaacacttt gtagaagaaa ataatgaatg agactttctt ttgagatttt 116220 cttagcctct tagttgttcc cagttaaagc ctcatatttt tccttttcat gacaataaaa 116280 ataataataa aatcagtaat aaagtgaata tatgagatgt taacctgttc ctttatgaca 116340 atgtcctgtt taccaattaa cagtgtgttt ttgtggtgat gggggcaaga caaatcttta 116400 aatggtggaa agcaaagaaa gaaattataa aacatgatta gttgtattat acgttgtttt 116460 tggttgttgg aaaaactata catttattga gagaatcatt aggaagctga acatcagcta 116520 tattgctgga gtgatactgt ttcagtggtt tcttgacctt tttgttgttg ttgttgttgt 116580 tgttaaacac agaccaacta cggttgaaaa cgtaaaaagg attgatggtg tttctgaagg 116640 caaagctgcc atgttggccc ctctgttgga agtcatcaaa catttctgcc aaacaaatag 116700 tgttcaggta aaatactgtg gtttgcagga gctcttagag aataagcatt ttttgtaacc 116760 atttcaaaag taccctccag aagcaacatt tgctcacttt atttgcattt ccatactgga 116820 cacttagaaa atgaattaaa attgttttta cagtcaatct gttgtaaaaa catgtcagtt 116880 atctactttt aaagatgata ctaaaaagta gttgtccagg ctgctgatgt ctttctattt 116940 cattgggagg ttttgttttt aaattggaaa cattatttta ggttgataaa ttataatttt 117000 acattcaaat gtggtagttg gaatttaaag ctggaaagtt atccttgcta tgagttggtc 117060 aggagctcag ccactttctt ttggtttagc atcttctcta atctccctcc ccttccagta 117120 atgctgtctt ttgatagtaa gtggatttca tattattctc ttcagtttta atagtgtttc 117180 cttcatatcc ttttattatt gcttgttctg ccctaagtga ccatttccag aaatgtcatt 117240 taggattttc tctaaactcc acgtagcaga ctctataatg catactctgc agaaggtgag 117300 gcagtgggag gtagagggga gactactaga ctaggagtca cggaatcagg actttagttc 117360 ttccttacag ttgttcacct ggtgaacctg cacatgtcct ttaatttcct tgggtctcca 117420 tttcctcagc tatacaatgg aaatgacact tcctccccca catccaggaa acaacagatg 117480 acattagaaa atagaagaca tgggataagt ataaaatgtt gaaagagtta aacacattca 117540 aggcaatatt aagggattat tttttacttc caagaagctc ctggaagctt tgggcaggca 117600 cagttggatc ctactttaga aaaatctttc tctaactata agtagaaaac ccttctgctt 117660 tttgaatgta gcatttccct cttttgatat agagtatctt tggcaacttt gaattttctt 117720 tttcatactc ttatataaga catcatgtga aaattcttat ttcttactga gtttttggaa 117780 atgaaattat aatgtcttaa tagtttgaga aagaatatca tacctaccag cggtaattga 117840 gtaagttccc tctctttgga cacttgaaag tagtatcttc tttcatgaat tagtgatatt 117900 atttaataat gaatgagtga tctctcctaa ctccccttca gaagaggaaa atgaagtagg 117960 ggaaaaggta aattccccaa gggataggta tgaaaccttt atgaaccttc tggatagaga 118020 agatgactgc tgatttctgt gattagaaat tatacttggg ttattctgca aattgaaatg 118080 aattatttaa aaaaaaacaa ctttaatgtt tattaagcaa gttttgttat tcatgagttt 118140 cattagcctt ttattttttt tttaaatttt gaagtaaaat ttcttgctgt cacaatacac 118200 attaaaaatt acaaatatga cacatattaa acacattaag atggccgaat aggaaaaata 118260 tgctaaaata tttttatata aatacatttt ttgagaattt tgagaatttc tggaacaaag 118320 taatgatata atccataaat gtacaattaa agagtttaag gatatccaaa atacttggca 118380 aagtaatctg aaataatact cttaggaagg tagggcaaga atgtgattct agtaagcaaa 118440 aatgtgatca aatcgtattc tagtcccagc tactcgggag gctgaggcag gagaatggcg 118500 tgaacctggg aggcggagct tggagtaagc cgagatcgtg ccactgcact ccagcctggg 118560 cgacagagcg agactccatc tcaaaaaaaa aaaaagacta tatgaacatg tatggcataa 118620 atatgtacaa atattattta ttttaaaaaa attcaggggt agggacaggg tagttagaaa 118680 atatctaagg atgttcatga aataatactg gctatgaatg acagttgatg aaaccgggtg 118740 gtgcccatct tattccctcg actcgtgtat atgtttgata tatcccacaa taaaccttaa 118800 aaaaaaaaag atgagtggtc aattatagga agatataaat agaaaaggca ataaggacaa 118860 aagttggcaa agcttaccta agcactcttc agataaaaag acatttttgc taactagatt 118920 tgaatattat agtttaattg tcaaggaaaa tgcctcaact taatctttgt taagagacta 118980 cttaaggcac tatcagaagt tccctcatgg caaggtgcaa tccctcatgc ctgtaatccc 119040 agcactttgg gaggccaagg caggcaggtt acctgaggcc aggagttaga aaacaacctg 119100 ggaaacatag tgagacccga cctctacaaa aacaatttct taaaattagc caggcatggt 119160 ggtgctagcc tgtaatccca gctatttagg atgcttaggc aggaggattg cttgagcccg 119220 gggatttgag gctgcagtga gccatcattg tgccacaata ctccagcctg agtgatagaa 119280 aaaaaaaaaa aaagtgtctt tgttatattc caaacttgtt ctcaactttc aggtgagctg 119340 gcttcctgta taactcttgt ataggacaga acatactggt tggggcaagt gaaactgtct 119400 agttgtatgc ctcataaatt aatgaatttc ctttctaata tatacactga tatttataca 119460 cacatacaca taaaaccaag ctcaatagat gggtagtgca gctctattcc ccaaaaccca 119520 actaccctgt aacaagacac attagacttt tgagattgca aggatgagga ctgaaatgct 119580 ggcctagacc atggtgttgc catagtgggg tgaccagtct gaatagccaa caatgcttcc 119640 tcagtaaata cccattttgt cttggtggga tttctataaa ttgcaaaatg cagctattat 119700 gaagctgtaa aagagaaaca gaaacatgta acacctggga ctgttttatt aggcccaccg 119760 tatgctcaga acatgaaatc tccactgcta gggttatttg attgaaatta tcttttgtgt 119820 tgatgtgaga gtttagctct gagattcttc cacatgtaaa atgtaatccc ccaaagtatt 119880 tggcaagcac attttattgc cttgggtcag ataattgaaa cattaggcat catatatata 119940 gcatgtaaaa agtaaaacag aaacatttat gtttctcacc aagcagtaaa ttagtactca 120000 actaataaat ttcttaaact ccctaataac agaatatgga aacaaaaaat aaatctttcc 120060 aaaagaagag ctcatggaca catttcctca tatatgtata cataatatag tagaacacat 120120 gataaataac ctataaaaat gataccaata tcattcatca agagacgagg ctcttcttta 120180 aattattaat ttcatctgtt acaggtttta ttatgactgt agtatgctgt tttcatctac 120240 cttttatgtg tagttaaaaa aatagttttc tatctcttta cctttatttc agcctttaaa 120300 aagattccat tattttttca ttaatcttgt ttttcagttt ttcccatttt ttcttttaaa 120360 catttcttaa ggaaccatat ttaagatttt atagaatact tagatttcta gttgggatgt 120420 atcatttaaa attagatatg tagagagagt gttatgatat atttccttac gatatattag 120480 tggttatagt acctaaattt gaatagtgat tctgttcatt cattcattca ttcattcaat 120540 attcacttcc aggagattgg ggacttattt aaagacagag tagttcacat tatagttcct 120600 ttttttagtc cttcttattc gttaaagaaa agactaggaa atgtttgtta ttacaaatat 120660 tttattaaaa ttttgtgtgc tctagcatta ttttaccttt taaaatcaat atgttaaaaa 120720 tccaacttct ttttgagctc cccataaaaa gggaattatt tgttgcttat gggtttaact 120780 tgtgttattt ttttcttaat ggctaattat catacatata ttctattatt gtattgatat 120840 tactgatcat ttgtgctaca ttaaaaattc tgtagacaga cctcttttca agtacaaaac 120900 ctcaagaaga acagaagacg agtctggtag caaaaaataa aatatgcaca ctttcacagt 120960 ctatggccat cacatactct ttattccaag aaaagaagat gcctttggta agtgtgactt 121020 tcatgttaca gggaattttt ttagtttact taaacttgtg ttttatcagc tttttagtat 121080 taaagttctg acttgggatc aatttcctcc aaccctacaa taaatctcag tttatcttta 121140 attttaaaag agaatgttgt tttctttttc tgttaagcct ccctgttaag taatagcagc 121200 aagtttagtt tggccatgaa tatcttctag agattgtatc ggggtactga taaacacatt 121260 tgtagctcag ggatactgca tcagccatat tttaaaatgg gactaacagt ttaaaaacta 121320 taaatattca cagtgttaag aaacaatctc aagatgcatt aagaaaaagg aaggtgcaaa 121380 acagaaaaac aaacgtaaac gtgtgtgcat atgcatgctt atatagtcac atattcttgt 121440 atgtgtacaa aaaatacaca ctggatctct gcaagcatag ccaagcaact ggaaatatgt 121500 ttttaaaaac ttgcttttca ttctatctct tctagtactg ttttgatgct ctttgaaaac 121560 aatctaattg ctgtaacaaa tgaccatacg taggccgggt gtggtggctc atgcctgtaa 121620 tcccagcact tcgggaggct gaggcaggca gatcatttga ggccagggat ttgagaccag 121680 ttggacaaca tagggagacc ctgtctttac taaaaataca aaaattagct gggcgtagtg 121740 acgcatgcct gtaatcccag atacttggga ggcggagaca tgggacttgc atgaacccag 121800 gaggcagagg ttgcagtgag ctgagattgc gacactgcat tccaacctgg gcgaccgagc 121860 aagactcggt ctccaaaaaa aaaaaaaaaa aagaccatat gtaatgtttc ttcattgttc 121920 taagataaat ctttaaggct gttgaggttt tttgtataca aaatggagag taagttttaa 121980 tgggatggga caaaatgagg cttacagttg agtttaattt gagttcacat cctgttgaca 122040 ttaagttgat ttggaacaag tgatatggtc caatgcctgc ttttctattg tctgtggttc 122100 catccactag tgcctgtgtt acacacctct tgttcaggtt ttatcattta aaataaataa 122160 gaataaacag tccatagctt atcttactta ctgaataaat gctctaattt gacagtcatg 122220 tttcttaaag ttccttacaa aggccattgc ccaagaaacc aaataattcc attatactat 122280 ttttgaaata gaacacataa taaatgggaa ttttaagttc agtttcttat gtaaacaata 122340 acttctatgt acatgttaaa tatgcctgta tatacctaat ttgaccatgt atgtatagta 122400 gaaatgaaaa cagttactaa gaaaatttgt tattggctcc aaattttctg aattaagtgt 122460 attctaatgc tcagccataa tatggggttt catgtgttag tttatgtatt catggttaaa 122520 aatgtgaaga ctgttatatc ttcatttgtg tcttttggta ttatttggtt gtattttatt 122580 gtgtgatatg gtggtataat tatccttacc tcccaggagt ttgagagggt cttgccagtt 122640 aaccgcagaa ttaaacatgc ttaggactaa ttaatcagga gcaatactac aattagttgg 122700 aggtaatttg aaacctggtt tcaaataacc ctgatattat gcacacatgg tgcacacttt 122760 tctagtagac atttaatgaa agtaatttaa aacctacctt tgaaggatga aaaacattgc 122820 cttaaatgct ctattctgtg aaagtatcaa catttatgca aatacagtct aaattcagac 122880 tttgaaaatg tattgaaaga gaggatcatg aaataagtta gagctgagtg acaaagcttt 122940 ctgagtgttt aaaagaatgt tttacctaat aaatatctga aatgtatttg gagccacatt 123000 tgtttaaaga actgtataaa tatgtagcac tgttcatgtg aagttcaata gtaggaaaat 123060 gctgacagcc cttgtggaac tgtggttatt attattttat gaatagagcc aatttcaaac 123120 acctattaga gtcttctcag gaacatttta tagaatgcat ctggagcctt atgttatctc 123180 taagcatttt aggatttgtc ttcttggaaa ttcatgtaac caaaccacca tgtgttattt 123240 caagtgtata tagtattggg ttacagttta ctatgttttc agaaggttgt gacaactatt 123300 agacttacag agaatgactt ctctgccact aacggctttc taaagtgaat agagaggggc 123360 gaggattgaa ttcttcggta aagctgggtg attttgtttt attcaataca gtataataag 123420 tataaaaagt agaacctata gagagctata atgggggtag ttttaaagaa attctgaaaa 123480 tgaaaaactt aagtaaaggt ttagttcatt gtttatttca cactgagcat ttactacctg 123540 aatgttttgg acattttatt tccatgactg gagtggacac ttttacaact cactgggttc 123600 tttgctgatc tttctctaga agagcatagc tgagagcagg attctgcctc tcatgacaat 123660 tggcatgcac ttatcccaag cggtgaaagc tggctgcccc cttgatttgg agcgagcagg 123720 cctgactcca gaggttcaga agattattgc tgatgttatc cgaaaccctc ccgtcaactc 123780 aggtgagagg catggcctag ctctgcaccc ttaatgactt gatgaagtaa acaagcaatc 123840 cactatattt ttcactgtta acagcattaa tcctttatgc tattatgaaa accttacttt 123900 tgtgattctt tttcttgttt taggaaaaca atctttcttc ccattatcac tcagaggaaa 123960 gtatactgag aaattttttt gttttgtttt gttttttgag acagagtctt gctctcttgt 124020 ctaggctgga gtgcagtggc gtgatcttgg ctcgctgcaa cctctatctc ccaggttcaa 124080 gtgattctct tgcctcagct tcctgagtag ctgggactac aggcgtgtgc caccatgccc 124140 agctattttt tgtatttttt gatagagaca gggttttcca tgttggctag gcaggtctcg 124200 aactcctgac ctctgatgat ccgcccacct cagcctccca aagtgctgcg attacaggtg 124260 tgagccatgg cacctggcca atacactgag aaatttttat tttccttttc agcttaaggt 124320 tacaacttcc ccaccatcca aaacgtgcac tttcattttt tttctaattt ctatctcatc 124380 acttgcaaaa accatatttt tctccacatt cattcccagt agcttcctga ctcctagttc 124440 ttccctaaat ccttctgagt ccttgtcatt ggtttcgctt gagtagcctt tctaatcaac 124500 acagtcattg gtatcagtta ctgtgacatg gaagggacag accaagttct gtgggccgct 124560 acgtagaagg atttcctgtc actttgctgc agaacctcag ctcgcggaga gcaagcccct 124620 ttgcttgccc tgtagaaata ttttaaatta ttatcctttt tttttttaac agaagtaaat 124680 aggagatacg ttagaggatt ttctctccta gatgtgtaaa tacaaacttg gggtcttata 124740 actcaataaa tctgataaat ttcttttgac tgttaggata gagcagtggc cataccaata 124800 gcctcatctc caaagctgca gtgaagatac tttttactac cttaaagtct ttcccatttg 124860 tgaacaactt gtgaacaatt ccccccaaga atttggaaga tcactctctg aaagcacagt 124920 caatactgta cttaaatgga tctgagcaaa aataagtcac ttagaagaca ggattatttc 124980 tagacttgag tgtgacttga ctgaaggtct aaagaacaaa cagctccttc acttccattg 125040 atcacggtgg aagcacaggg aaaggacaga cacggaggca agttggagta gtgctcatct 125100 aagttccagg gatgcggggg agtggccagg ggacttcagg tatagtaaat aaataaccta 125160 tttataagtt atgtcaatgt catgtttgaa atagaaaacc aaatactgca tgttcttact 125220 tacaagcagg agctaaagtt ggtgcatatg gatataaaaa tgagaacagg ccgggcgtgg 125280 tggcttgtgt ctgtaatccc agcactttgg gagacctaga tggaaggatt gcttgagctc 125340 aggagttcaa gaccagcctg agcaacatag tgtgaccccc atctctacaa aaaataagaa 125400 aattagccag acgtggtggc atatacctat agtctcagct acttgggagt ctgagtcagg 125460 aggagtgctt gagctcagga gtttggggtt ataataagct gtgatcatgc cactgtgctc 125520 cagcctgagt gacacccaga gtgagaacct gtctcaaaag gagaaaaaaa aaaaagtaac 125580 agtagacgct ggggactact gaggggaggg aaggaacaat ggttgaaaag gtgggaaggg 125640 acagtggttg aaaaactacg tgttgggtac tatgctcact atctgggtga tgggatcaat 125700 tgtacctcaa acctcagcat cctgcaatat actaatgtta caaacctgcc catgtactac 125760 ctgaatctaa agtaaaagtt ataatttaaa aaaattataa taaaatcaga aaataaaggt 125820 ctgagatgga aaattaaaag accaaagcca cccataagca caataaatcc ctccccccaa 125880 aaaattatat ctattaaaaa aaggtgttgc gccaggcact gtggctcatg cctataatcc 125940 tagcactttg ggaggccaag acgggcagat gacttgactt gaggtcagga gttcaagacc 126000 agcctggcca acatggtgaa accctgtctc tactgaaaat acaaaaatta gccagcagtg 126060 gtggcatgcg cctgtaatcc cagctactca ggagactgag gcaggagaat cgcttgaact 126120 ggggaggcgg aggttgcagt gagccgagat catgccactg cacttcagcc tgggtgacag 126180 agtgagactc tgtctcaaaa aaaaaaaaaa aaaaagacct tgtaccctga caagttttag 126240 tttgtgcagg aatgctagaa tgactcaaga ttggaaaaat ctttaaatgt taattacaca 126300 ataagggtaa aaggagaaaa attacctaat gtcatctgag caacaagaag aagaaatgaa 126360 aggcattaaa aattgggaaa aatttatatt tgacagtatc ttaacaacga attctgcttc 126420 tatatcactt cctagctttc tgatgataac ttcccgtgca gatctgtatg taaggaatgg 126480 acgtagtagt catgctaatc tgagtattta tctgtgtgat acttacgaat taacgatgta 126540 agttaataag ttagcatttc gtgaacctgg ttaataccat ttgctaaggt taaattagcc 126600 aaatcctgaa gtaagctgta aaacatccaa ggtagggtag agaggcatct tatgagaaag 126660 ctggccaact ctcctggtca ccttctaatc ttcctaactt cagaaatcaa ggcagagaga 126720 ggaaaatagt aattactttg taggattaga tttatggttg tcgaaacctt tgtttctcca 126780 gtgcagaatg agatagcgtt ttagggaaag ccaaagactc agatgtcttc ttcatgctca 126840 tcgtgtggaa tttttcttcc tttagaaatg tattgtctct cagggcttaa agcaatttgc 126900 atctttcgat gagacattga gtaataggca atattctctg aaataatttg tgcaggctgg 126960 gcacagtggc tcacacctgt aatcccagca ctttgggagg ccgaggcggg caggtcactg 127020 aggtcaggtg ttggagacga gcctgaccaa catggtgaaa ccccgtctct actaaaaata 127080 ccaaaattag ctgggcttgg tggcacacac ctgtaatccc agctacttgg gaggctgagg 127140 caggagaatt gcttgaaccc ccatgggagg tggaggttgt ggtgagccaa gattgtgtca 127200 ttgtactaca gtctggacaa cagagtgaga ctctgtctca aaaaaaaaaa aatagaattt 127260 gtgcagttcc ccccaccccc tttttttttt ctgttggcat ttttgctatc atttagctgc 127320 cttctttata tcctgaaact tacaggtggt gttggtctag tcagtaagag caaaggcttt 127380 gggaatagat agatctgtat ttagaccttg gctctagcat ctcattgtta tgtgacctcc 127440 atcaagtgac ctaatttccc taatattcaa tttcctcatc tctaagacag ggagttaata 127500 ttgcctctct tatagaattg tgagaaatat agtcatgtgt cgcttgatga tggggatgaa 127560 ttctgagaaa tgtgttgttg ggcgatttca ttttgtggga acctcacagg gtggacttaa 127620 acaaacctag atggtatggc ctactacaca cctaggctgt acggtatagc tcctgtcttc 127680 aaacctgtac agcatgtgac tttactgaac actgtaggca attataacac agtggtattt 127740 gtatatataa acatagtgaa acatagaaaa ggcccagtag aaatacagtg taaaagattt 127800 tttaaaaaag ctgggcatgg tggctcacgc ctgtaatccc agcactttgg gaggccgagg 127860 caggcagatc acttgaggtc aggagttcaa gaccagcctg gccaacatga tgaaactccg 127920 tttctactaa aagtacaaaa attagctggg cgtggtgttg ggtgcctgta atcccagcta 127980 ctcaggaggc tgaggcagga gaattgcttg aacccaggag gtggaggttg cagtgagtca 128040 agattgtgcc actgcacttc agcctgggag acagagcgag actctgtctc aaaaaaaaaa 128100 aaaaaaaaga gataaaaagg tacatctgta cagggcactt accacgaatg gagcttgcac 128160 cctgggagtt gctctgggta agtcagtgag tgagcggtga gtgaatgtga agacctagga 128220 ctgtgcactg ctgtagactt tataaaccct gtgcacttag gccacactca cccctgtgat 128280 acgagtctac ctactgtata acgtacctgc atatgtaccc ttgaaactaa aacaaaagtt 128340 aaaaaattta tcttcttttg ccaataataa attaacctta gcttactgta atgattcttc 128400 tttatgaatt aaaatctttt tactcttttg taataacact tggcttaaaa cacaaacata 128460 ttgtacagct atacaaatat attttcttta tatccttctt ctctaagatt ttttctgttt 128520 ttgattttgt taaatttgtt tttacttttt acattttttt tgttaaaaac caagacaaaa 128580 acccacacat cagcctaggc ctacatgggc tcaggatcat cagtctcact atcttccacc 128640 tccacatctt gtcccaccag gtcttcaggg gcagtcatat gcatggggct gtcatctcct 128700 gtgataacaa tgccttcttc tggacacctc cagaagggcc tgcgtgtttt acagtgaact 128760 tctaaaaaat aataaaatgt atagtatagc aaacacataa acatagtaac atagtcattt 128820 attatcattt tcaagtatta tatactgtac ataattgtac atgctagact tttacacagc 128880 tggcagcaag gtgagtttgt ttacaccatt accaccacaa acacatgggt gatgctttgc 128940 attgtgatgt tacgatggca tgatgtcact aggtggtagg aacttttcag ctccatgata 129000 atctaatgga tacttgttcc tgttggctgc ccgtcgttga ctgcaacatc attatgtggt 129060 gcatgactgt aaattagata ctgttcagaa agctttggca cactggtaat agcaaatggt 129120 ggtggcaaat atgatgatga tgatgatgat gattgaagac atagatggta aaattttatg 129180 gtgtcttaaa agtaccctct aaatatgatt atttttatag tctgtccttt tgaataggca 129240 cttaagaatg tatgaactta ataagtatat aagaaagaat gttccccaaa atatatctta 129300 cagaggcata caatttaaga attcaaacag gttgtaatgg ggtgtgtgtg tgtgtgcaca 129360 cgcgcacgca tgcgtgctca ttcacactaa agaattcttg ggcatatgtt cctgaatgtc 129420 ctaaatggac attctaacat cacttcatta tgggcagagg gaaatggtaa agaaaaattt 129480 catattatat tattcagcca catattgaca gcatctgttt tatttgccta tggtaaagaa 129540 ttgaagcact gttaatttgc tttttaaatc atgtaggcac aaagttatcg aactttagat 129600 ttagaaatga aactggaaat cattacactt tccctttcct atccccaccc tgttttggag 129660 agaaagagtg tgaggcttag agagttataa aactgtttta ataccatgtc taagattaat 129720 aactgaacaa gtttctcttt ttactcgtgt taaagttgta ctgccaatta acttaaaaga 129780 aagaaatatg caatttctaa tcctgatata ggatatgggt atataaactc taacttgatg 129840 agtgaaacaa attaacttat ttataatcag tttcatatct ttatttattg agtgtcttta 129900 aatacccctt acctttaaag taagaaatat taaaatcaag cagaatataa taatgaaaaa 129960 ttcttaagat atacttacta aaaacttatc cttcggttaa tacactgtat gtaggttgta 130020 catacaatat gaaaaagtat atttttgtag cctactttta aatccagaat agaggaggtt 130080 aagaaggttg tgataaccat gagctctttt tttttttttt ttgagacaag gtcttactct 130140 gtttcccagg ctggagtgcc gtggcacaat catagcttac tgcagccttg aactcttggg 130200 ctcaagcaag ccttccactt cagccttcca agtagctggg accacacctg gctaattttt 130260 aagtattttt gtagagatga gttctcacta cattgcccag gctagtcttg aacccctagc 130320 cttaagcgat cctcccacct cagcctgcct aagtgctggg attacaggtg tgagccactg 130380 agcccagccc tcttttattt cttttgatag tacactcata atcattaaac tatcatttct 130440 ggatgtgaga ttgtgctttt ggattcttat tttttcttta taaaatactt tttgttctct 130500 tactggagaa aacattgttg gattataaat gatataacaa ggaatgagga tatacatact 130560 ataataacga ttcagatatg ttattttcat attttattta actgtagcca tgccacaata 130620 atttagagtt ttaaagaaca agtttgattg aaatctaaac tttgtacaat cctgaattga 130680 gaagtttcct gtattttatt atgacacaat atttacctaa aaatagagta attatgaatt 130740 gagaaaacat agctattaat ttcatactct tatttgttaa gtagattttg tctggaaaac 130800 tgttcatatt taaaggagct ttgtaccttt gtattctttt tgtttttcct tgtttatata 130860 attttaaact ctgtttatgg atttgggatt ctaactatgc taaataataa attaaggcat 130920 tgaatgaagt acctagacag tattttgatt aattttattc ccccattctt aatgtgcatg 130980 taactggaaa attaagagtg gcttccaagg gatctactac aaaagtaagg ttaatatgat 131040 ctcttttaaa acactgaagg cgtgtagcca gtgttgtcat taattctgca gtagatattt 131100 tcagcactta tttacatggg aagttagagc agagtaagat gcacctgtaa agctaaatgc 131160 cacttatttg catatatata aaacgcagga tgaatttacc atagaaatat aaagggtact 131220 tatagaaatg tattagaaaa atatatgaat ttttaactta tatctagaag ttaactttat 131280 acatttaact ttaaatcatt aatagtggtt taacaccata agcggatgtt tatgcatcat 131340 cattttatga acaaaagaca ttctaatttt agaaataaag tgattcaaaa gagaataaaa 131400 tatcttactt tttcttttaa aattaatttg tttagcgcat tacatgataa tagctcaagc 131460 ttgtgtgatt tttccctaaa aaattggttt ataaatatta catttatagt atgaagaaat 131520 taatcataca tagtttattt atctaatttc taaataccca tggaagaaaa tgaatttaat 131580 ggaatgtagt tgtgtattac ttggtttcga gtgtgggaaa atttatatgg tctttctaaa 131640 acagcactgt cagtagaaat acaatgtgag ctacatatgc aattttaaat tttctagtag 131700 ccacatttta aaaagtaaat ggatgcaatt tattttgata atataattta attagtctac 131760 tatatttaaa attttatcat ttcaacatgt aatcaatatg aaaattatta atgagatatt 131820 ttacatactt ttttctgtaa taagcctttg taatcaggta tgtactttat atatacaaca 131880 aatcttctga tgctaaattt taactggaaa tacttgatct gtgtttagct tttgtaaaat 131940 ttactgttga acaacgtgga ctaatgtgcc taagtggttc caaacatatt ttaaaatttg 132000 aagacaaata aaagggaact caaagtaaat tgggatacat acatacaaca gaatactgag 132060 ccattaaaaa atgatgaaat agtaaaattg ggggaatttt gatgatacta ggatgatata 132120 atgaccaaga gacaaataca attttagttt ggttgagaga tgtgatcatc acgttgctga 132180 ttttactatg tatagaggtt atcttttcct ttctaagatt ttgaaacttt aattagttaa 132240 cccacttacc tagtttctat tagctgtgta actttctctt cctgtttttt gttttgtttt 132300 gttttgtttt ttgcttttta actgcagtat tttgaggagt cttggagtag caagctaatc 132360 tttggaagaa aggaaaatat aaacctgaaa actaacaatt taaagaacgt cttttcaggt 132420 tgtcatttga aaaatacttg atttctgatc actgatttga attgagtgtc aaatatttga 132480 tatgttttgt aaattaggtg aagatgagtg agtaggttct aaactgcttg ggtttaccgc 132540 actctggagc attgcagaag aatgtgatgt tggaaggaag tgctgaaaca taattattgg 132600 cttgcctata ggagggtgct acataatttt agaaggtgtc aagaaattga cacagtctga 132660 attagttctg ttgagttgca aaaaatgtaa agtttcttga ttctgaaaat aagaaatatg 132720 ttcccagaaa tctcatctag ttaatgtgct tttaaaatca ttgatgtctc ttgttattac 132780 aataatagcc attgaaagaa tcttttttat tagaatgtta tttacaggta cgattagctt 132840 ctatttaaat aaattatttt tatacttgat cttaggcaaa aggccaacaa gtgatcagaa 132900 taaattattt taagagaaaa ctaattataa ttgatatttg gaattggaag cacaatttcc 132960 tttagaacaa ttccacgaat ggttgttttg attctcaagg cagcccacaa aagacagttt 133020 gaaacacaat ttatgcagtg tcaatagtac tgacctgact ttggatcttg gaggcagggg 133080 cttcaggtga tacccgagtg gagtttttac tccatttcca ttccgtaagg ctataggcat 133140 ttgaaagagg aaacttttct ttggcaacct tccaccttcc tttctacaga atatttcagt 133200 atttctagct cataggtttt ctaaaatatt ctctgtaatt tattttgaaa tggagttttt 133260 ttatcgttta cagatatgag taaaattagc ctaatcagaa tgttagttcc tgaaaacatt 133320 gacacgtacc ttatccacat ggcaattgag atccttaaac atggtcctga cagcggactt 133380 caaccttcat gtgatgtcaa caaaaggaga tgttttcccg gttctgaaga gatctgttca 133440 agttctaaga gaagcaagga agaagtaggc atcaatactg aggtattaat tatatataga 133500 attttcataa agtgtcagtt tgttcaattt gcatatccta gtactagaat gctgtatttt 133560 tttgaactgt tatgaattct gatatgatta ctttctctat gtgctacatt tcctttgctt 133620 ttcataaata tgatctgaga aaagtgatta aaaaaaagac agtaaaaggg aggtttagtc 133680 catctgttta gcttattatg tagaatgtca gcttaaattt tacctgtacc tcatattgac 133740 cgtatagcct ggaaaatctt tcggaggtat agttaatgga tttaagcata tggcagttta 133800 tgtagttaat gaaagtgaaa acaaattgta ttataaatac ctcccaaact ggtttattat 133860 cattctatca ttcttcatgc tctgttagta tgatattgaa tatctgaggt accaggatta 133920 ttgttgcttg tggctctgag catttcgtag tgcttttgca tgatgagaga aagattacaa 133980 atttagtatt atgttagatg gtacgtttta ttaaaatcaa atgcttcaaa aataattgct 134040 ctgtgtatgg catgagataa atagcaatca gatatattgt ttaataatat gactctatta 134100 aatgatggca taaatttgaa aatttgacct tcggtatctt ccgggtctaa aattatatga 134160 ctccattata aatattttgg aaatgattaa ctaaaaaatt gtttcaattc ttagttggta 134220 aattcaatgt ggtagtaggt ggtggtgatt attttgtatt agagaattag gaattacact 134280 tagttctaag gtaatcttta taggatgtcc agcaattaaa cccctacttt tttgaattgc 134340 ttaaaaataa gggaactgat ctttttaaat tctgtacttg agttacgtct gtatatatag 134400 tcatgtccta gataatctaa tggaacttaa ttagttggaa atctttatat tgtttataac 134460 tgaactagct ataagaggaa cattaaagaa aacatatttt gagtggaggt aatgaaattt 134520 agcttctaat gctcagcctt ttatttctgt aatctatacc agatacctaa gaccctctta 134580 ttgtttccca gcttcaacct gtcagtatag aaaacggtgt aacttactat tttttctcaa 134640 tattgaagca catttgtagt gaaatattat tttaactata tattgccatt tttgcttttt 134700 ccctatttca gtaacatttt tcgctatttc agtaacatta catgtcaaca agagaatggt 134760 gggtattttg gggggggttg ggtggggaga aattttacta agcttgctag attctaaaag 134820 gtatacctta tttggcccct tttccccatt taggggaaca agggtgttgg ggctgggaag 134880 tagataagag gtgagtaagt catccaaagc atatgtcttc attagcctcc ctgtatgaaa 134940 agctgatttc tgtagagtgt tggaggccta ctttcagaat ctgtcatatg ttaacattca 135000 tcttctctac tgacctgatt tatatccctt agtctatttc attttataat tatgacaaag 135060 gataaagtca ttagaacaaa ttctttttat tagttgacgt attgttgtgt ttatatctct 135120 tgtgtttgtt attaagatgg aagctcaatc atgtccttgt ttaacagaaa ggtgatgtct 135180 tggcattgat aattctgatt caatatccat aggtacatgg tggattcttt aaatatttag 135240 tattctttta tttctggaaa gttttcttaa atgatagttt ttttaaaatt tcatttctat 135300 aaagttttct taaatcatac tttttagtgt tttattccat tacttcatat ttcttcttca 135360 ggaactcctg ctatacatgt atgttggatc ttcattaccc agcttcaata tttttcactt 135420 ttcatgcatt ctttttattt cttcatttct ctttaaattt ttttcttcct tttcaccttc 135480 tatttctctt ttaacataat tgtatttatt tctgtattcc acatagctta gtattcactt 135540 attttaaaat tattttaaaa cgttttttag atttaaaaat tcttttttta tttatatata 135600 catattttat ttttaccaaa ggagcaacac tattaactga agacttctat aatttttttc 135660 ttttatttct gattctttct tcggttttcc ccctcagttt tgaacttttc taattttgat 135720 ttgtgatgtc cttttgtatt ttagataatt ttcctaatgt tttccagctc atttggaaag 135780 gctacagttt tattctgtac ctaagcaagt ctttctggtg tcaaagattt gaccttgata 135840 cttttctttt gctcattttc gtatgagatt agttttcctg tactttcaaa agaaggcgtg 135900 gttcaagatg gctttcccaa tttcacatct gtctctaatg tttttgtgta atgtctaaaa 135960 tatggaaact tggtttatga gatctactct gccattttta tctgggcttt ctcttccttt 136020 tgtctctgtt gtacctgtcc tgcttggttt tgatttaacc ccagtggttt ctcctgaatg 136080 tggagccttc tcctagaagg cagcctcggc tagtcccagg gttcagagta gccagctgct 136140 ctcttcacct aagagaccac tgtggattcc ttgtactcac ttgctattgg cttggacaaa 136200 agccctccca ttttcagatg ctattatcag attaatctct cattaatctg tctttccagt 136260 gtatgcctgt gggctatctt ggggttctct tgttatcaga cacctccctg ctggcctctg 136320 ctttctcccg tacagatgtc agtactgtgc aggtcttaat tgctgttggt ggtttgcccc 136380 tacattctta cagttttagt ttcccaagga tacctttaaa cttggtttta ttgtaaatgt 136440 cgacaatgga ttttgggttt tactatctag ttctgtctta attctggaat tcagaaagat 136500 taaaagctct gttgttgcag ctgctgccac ctcttcccag taccctctcc tcctatgtca 136560 tttttttctt cttatttttc ttgactgtat aagagagaat gtatgacatt tcctgcttga 136620 ccgctgagtt tgattataaa ttaaaataca caatatttta tacaaattgt tttgtagaag 136680 atttatttac agatgctcat tcacaggtaa aattgactta tgaaaatagt tttcatgaca 136740 aatgtatcag gctcggtaac taaatatatg gattgatctt gtttataaat gaaattaaat 136800 gtgaatgtaa cttacatatt tctgtatttg cttacatccg tatgtacaca tataatcagc 136860 aaatgagttg atgtttccta ttcgtaactt aatggtaata gcttggtaac agagttggga 136920 gtattaaaaa gatgtaaaga gccccttaaa attttgttgc tgggaatttt agtgttctac 136980 tgatgaagga aatagacact ggaaggcgtt gtttctatta ggtaacttag atatcatact 137040 gaagacttca aatacttatt gttgacactc aaaagacaca cttagtgtaa gtaagcattt 137100 ccccgctttt cccaatgaaa taagatcatt attataattc cattataaat gctgatgatc 137160 atatttatag aaatatagaa gataagactt gaaatgatat tcgctaccaa ttaatgagtt 137220 tgaagaagaa atcaggatgt gttttgctat tttacattta ttcttattta actccaaaga 137280 attcagtgat gttatgtact attatttcca tttctctgtg aagacgttga agcttaagta 137340 acacgcataa taaggtcata catttagcaa gtggctcaat taaagttcaa acctggttct 137400 gcctggtttc aaagtctgtg ctactccatg gtattaggct acaacatgac ttagggtttc 137460 ttcctctgct ctattgctgt tcagatgtac tcctcttttg gcagagtggg agaaaatttt 137520 tgcaatctat gcatctgaca aaggcccaat atccagaatc tacaaggaac ctaaacaaat 137580 ttacaagaaa aaaaaaaaaa cattaaaaag tgggcaaagg acttgatcag acacatctca 137640 aaagaagaca tttatgtagc caacaaacat atgaagaaaa gctcaacatc actgatcatt 137700 agaaagatgc aaaatgcctt ttctgtatgc caccttatat ccccagtatt tattatttct 137760 aagtcatagt atcttacagt gtatataagt ctcatccgtt cttttgattt tctcttccct 137820 gcttgcaatt gggtacctag gaacaaagtt gcaatcttag ccagtttttt ctttagcctt 137880 tgctgatgtg tgaaaagccc ttttttctac cctggatttc tgtacttaag ctggaacagc 137940 taagttttta ccttttttaa atataaagtt tcagagtctt ctgccaagga tcttttgctg 138000 ttttcctact gttaaatatt tcaaagcctt ttttaaacat agggaatata atcaaacata 138060 gcaagcagct gatgaacaat atctagatag tcttcattat tgaaatggaa taaatggtat 138120 ttttgtattt taggctaaca gacaccttgt accttagata aggccaacct tctcataaaa 138180 tccctcagtt acttttatta ataataacca aattaactct ggattccagg gtgtactcat 138240 gatggaatga tttctctgtc atgttatcct gaggatctag tactctgaga taacataagt 138300 gtatgacact ttaggcttat gaaacactta gctacttaaa ttatttaatt ttttttcatg 138360 tgcagatggt attgtaccca aacactacct ttgtgtgtgt gtgtgtgtgt gcctgtgtgt 138420 gtgtttttga gacagggtct tactctgctc aggctggagt gcagtggcgt gattatagct 138480 cactacagcc ttgacctcct gggctccagt gatcctgcca aagtgttggg attgcaggcg 138540 tgagccacct cacccagcct taaattattt ttttttcaag gatgtttaac ctgagggtta 138600 gaggctcttt ggcacgtgag ctgctgaaat gtgtgtgaaa gtgttgtgca cgtgtatgtt 138660 tctctttttt tctgggaagt ggatctgtag tgattcttag atgagtctat gagacaagaa 138720 acttttattt ttttcattta tttagcgaat gtttgttaag cgtactatgc cttggccact 138780 ctacagggtg ctgattggac cagtctgtct acctaccgtt gtagatgtta gaagctatat 138840 tcttttcaca tgcctaatat aactctttgt gtatgtatac atgcccaggc atgttccttc 138900 ctcagaacat taaattcacc attttggtca actcaaagca agtacaccat gggacacaga 138960 tctgaaataa tgtccagatt tttacttact gaatgaggtg tgttgagtgt ataagactac 139020 atgatgagat ggcaagtaat tgcctgaaga aatgatgtag tgattttgtg tgtcttatat 139080 ttatttactt tttgatccag aaataaatta tatagatacc actattttgt ttggatgggg 139140 gagaaaggat gggtgtgtat tcaggaactt atgttacttt tttgcaacta ataccccttc 139200 tcagtagtac aaagatttga tttctttttc tttctatttc ctacagactt catctgcaga 139260 gagaaagaga cgattacctg tgtggtttgc caaaggaagt gataccagca agaaattaat 139320 ggacaaaacg aaaaggggag gtctttttag ttaagctggc aattaccaga acaattatgt 139380 ttcttgctgt attataagag gatagctata ttttatttct gaagagtaag gagtagtatt 139440 ttggcttaaa aatcattcta attacaaagt tcactgttta ttgaagaact ggcatcttaa 139500 atcagccttc cgcaattcat gtagtttctg ggtcttctgg gagcctacgt gagtacatca 139560 cctaacagaa tattaaatta gacttcctgt aagattgctt taagaaactg ttactgtcct 139620 gttttctaat ctctttatta aaacagtgta tttggaaaat gttatgtgct ctgatttgat 139680 atagataaca gattagtagt tacatggtaa ttatgtgata taaaatattc atatattatc 139740 aaaattctgt tttgtaaatg taagaaagca tagttatttt acaaattgtt tttactgtct 139800 tttgaagaag ttcttaaata cgttgttaaa tggtattagt tgaccagggc agtgaaaatg 139860 aaaccgcatt ttgggtgcca ttaaataggg aaaaaacatg taaaaaatgt aaaatggaga 139920 ccaattgcac taggcaagtg tatattttgt attttatata caatttctat tatttttcaa 139980 gtaataaaac aatgtttttc atactgaata ttatatatat attttttagc tttcatttac 140040 ttaattattt taagtacctt tatttttcca ggatgtcaga atttgattct aatctctctt 140100 atgtagcaca tgtgacttaa tttaaaacct atactgtgac acagagttgg gtaaacgatg 140160 attatttaac tttaagcagt tcaccatcca tttcaaagcc tttgattggc ttttttgtaa 140220 ataaaaataa cttgttaaga aacaaatata tctgtcatag aagaactaga aaatccaggg 140280 aagtgagaaa aatgaaaata aaaatcattc atagttttac tagtagctaa tcacagtcaa 140340 cctcttttgt gtatcccacc agactttttt atattcattt gtttttagtt aaaatataaa 140400 agtctcgtat attcccattt ttctgcattg cattaccaga aggtagtggc gcctattaaa 140460 tatgtgatat gttgttgtcc agccatggct tctgcatttg catgcttttg tgtgtgcatc 140520 tgcaataccc tgtgaatatc ctgtgtgatg gagtggcaag tacgcacaga cacgtctgct 140580 gcatgcctag gtacgaggct gtctccagga gaagcacttg tttgattatt tgagttgcca 140640 attgaatttg ctgctttttt tcatggcttg ccattttcac tgaaaagaat gactaatgaa 140700 aaacgatgat tggttattag atttggatgt ttggcagaca ttttctcaaa attgaactaa 140760 gttggcctct tcacggaaaa caactggtat ttgttgtgcc aatgataaaa ttggagattt 140820 ctagcaaaat gtataatttt ggaaaagttg tgttcctcca ctggaagctt gacagctttc 140880 cttaacataa agacttctct ttctcttcgc tttcactact actactacta attcttcttc 140940 tgattcttct tcttctcctt cttccttctt ccttccttcc tcctcctcct ccttcttctt 141000 cctcttcctc ttcttctttc tctctttcct tccttccctt cccttcccct tccttccttc 141060 cttccttcct tcctccctcc ctccctccct ccctccctcc ctcctttctt tttctttctc 141120 tttctttctt tctttctctc tctctctctc tttctttctt tttctttctc tttttctttc 141180 tttcaagcag tcctcccgcc tcagtccccc aaaatagtgg gattacaggt gtgagccacc 141240 atgcacagcc ttacataaag ccttttctaa tgagatggat agtaattaac aaatgtgagt 141300 ttttgatatt atataaagat tttttctgtg tttcgaagat ccgtataact cagtgaatca 141360 gtatgttctg gatgactaat atgtgatgtt aagaaatcat gactgaggcc gggcgcggtg 141420 gctcacgcct gtaatcccag cactttggga ggccgaggcg ggcggatcac gagatcagga 141480 gatcgagacc accctggcca acatggtgaa accccgtctc tactaaaaat acaaaaatta 141540 gctgggtgtg ttggtgcgtg cctataatcc cagctactcg ggaggctgag gcaggagaat 141600 cgcttgaact caggaggcgg agattgcagt gagctgagac tgcgccactg caccccagcc 141660 tggcgacaga gcaagactcc gtctcaaaaa taaaaaaaga aatcatgact gggtaaaaga 141720 tctgttcaga gtacaagatg gaccaatgga tttgatatat ttgaatataa cagagtatga 141780 aaaagtttat tgatatagtt tcagattaca cactgcaact aatctttaag aaactattac 141840 ttgtccactt tttggtaaaa tttcagagaa caatgtccac cattatctga acaggctatt 141900 aaaatactct tctcttttcc aactacgtgc ctgtgcaaag tcagattttt ttcatatact 141960 tcagccaaaa cagcatatca aaatggattg aatgcagaag tagatctgag aatacagcca 142020 cttttgttaa gccagacaat gagatttgca aaatgtaaac aatgctgctg ttctcagttt 142080 ttaaaaatat gttttttaaa agtatttatg ttaatgtgta cttggtttac tactgctatt 142140 tttaaataaa acaagaaaca tttttaaatg tctgttttaa tttctaaagt ggtagtgata 142200 gatataaccc atattaataa aagctctttg gggtcctcag tgattttttt ttaagagtat 142260 ggaagggttc tcagacctaa gagattgaga aatgctgatg taatgtttta ttataaaggt 142320 gtaccatgaa ttatgtacct tacttcatat tgttggacat taaagttgct ttcagttttt 142380 ttgttttaaa 142390 <210> 5 <211> 142390 <212> DNA <213> Homo sapiens <220> <221> gene <222> (1)..(142390) <223> c.3233+1G>CiExon26 skipping mutationj <400> 5 gcaggaacgg gggcggggac ggcgctggag gggcgggtcg ggtaggtctc ccggagctga 60 tgtgtactgt gtgcgccggg gaggcgccgg cttgtactcg gcagcgcggg aataaagttt 120 gctgatttgg tgtctagcct ggatgcctgg gttgcaggcc ctgcttgtgg tggcgctcca 180 cagtcatccg gctgaagaag acctgttgga ctggatcttc tcggggtaaa gtgtcttcct 240 attcccgttt tcccagctcc gtgccccggg gtatctatag tgctaggctt ctgagacacg 300 tggaggcgct taggcccgcg gagcaggccc ctgggctgtg tttgggagat tctggaaaaa 360 cagactttct cccttttcct ttcccctctg gagcagctgg gaaaggcgtc tctcggagct 420 tccgccattc agaaagtgtt tccccgcccc tgacggcccc agcttgatgt ttaccttgcg 480 cgcttagtta ggattgctct ttctagtacg gcctttatta tggcagaaat tgagccacta 540 caggtctgca cagcaaagtc gagggaaata acctgctgtc tatgatttag caagtgatga 600 tggatatttt tgagttcaaa tcactcagtc tttaatggat tttcttttct ttttttccta 660 gttgaatctc agttgttctc aggctaggtt tgatatgaaa aatactactc cctattgaag 720 agggtaatat aattcttagg atgctaatac aggagtctgt aagtcggagt acttcaggct 780 ttttatggtt cggtacattt ctttttaggg gtgggatatt gggataagta ggacagttca 840 gatcttgatg tcattgaata gtggtgtcta cctaaaagga agaggctggg gcacaaaatt 900 ataatttaaa gtgtttactt cagccaaaat gaggacagct gcccaggact catttcccag 960 ttgccttggg gagtgctcct tcagccttgg ttacaagcag gtttttaaag gcgaagggga 1020 agagtgggct gagacaaagt tggtcaggaa ttgttattgg tttacagaga taccattgct 1080 tagtgattgg ctgtacactg taactcatag ggtatgagtt atcgtgtcca gcatatggca 1140 ttttatggct tcttggttcc agtctagagc ccatatagca ggtgggcttt aagagataat 1200 tatccagctc agaccgggag tgagacggga ctgttttttc attctaatgc ctctctgggc 1260 ctgataattt aaaggggctt gcattcttca gctaaaattt tattttcttt tatttttttt 1320 cccccacagt ggtctccctt tattaatcca acaaatgttt attaaggact gctctaggca 1380 ctagagatac caacaatgaa caaaacagac aaacatctct ctccttttgg agcttacatt 1440 ttagtggaaa gagacaggca aaaagtaaaa ttataggatg acagaaggtg aaaatagaga 1500 ttaaaaagga aagggggatg aagagtgtgt gtgtgtgttg tgggtggggg gctgtaggga 1560 gctgcagttt tacaataagt ggtcagggac gtcctcgctg agaagggaat ttttgagtcc 1620 agagctcaag gaagtgagag aacttacctt gacgttctct ggaggagaag aaagtacaaa 1680 ggccctgggg gaacctgcct ctttatgttc agagagcaac ttaagaggcc tagtgagctg 1740 gagcagagcg gagaggaggt cagaggtcag gccagaaagg gaaaggggcc agaatgtgta 1800 ggactttatg ggctatattg aaaattgggg ctttcattct gagggagatg ggaagctgtt 1860 ggagagttgt tagggaaacg tgatctgaat tatgtttcta aaaaattgga gtaagatatc 1920 ataaaatttg ccatcttagt cttttttgta tctggccaat tccactcaga attctttttt 1980 aaacagcttt attgagatat aattaatata tcatatgatt cactcattta aagtgtgcaa 2040 tacaatggtt tttagtttgt cttcagagtt gtacaacctt tatcacaatt acctttagga 2100 ctttttcatt acccaaaaga gaatctccat aaccattagt actcaatccc acccgctttc 2160 ctagcaatca cttacctatt tttttgtctc tatatagctc tcaaacccta tgatattcct 2220 tctatctaac tgtatttttg tactcattaa cagcctctct tcattcccac cacccatcca 2280 tcccagcctc tggtaatcac cattctactt actacctcaa tgacatcaaa ttttttagct 2340 cccacatata agtgagaaca tgcgatattt gtctttccct gcctggttta tttcacttaa 2400 cagaatgtct tccagttcca ttcatgttgc tgcaaatgac aggatttcat tctttattat 2460 ggcttaatac tattccattg tatatgtata tcacattttc tttatccact catctgttga 2520 tggacagtta gcttgattcc atattctggc tattgttgaa tagtgctgca ggaaacatgg 2580 aagtgcagat agctctttga catactgatt tcatttccct tgaatatata ccctgtagtg 2640 gatttgctgg acccgcttgt agttctacat ttaatatttt gagttatttc cataatgtta 2700 gtaataattt acattcccac caacagcgag gaaggagttc ccttttctcc acatcctcgc 2760 caacacttat cttttgtctt tttggtaata gccattctaa caggtgtgag gtgatatctc 2820 attgtgattt tgatttacat ttccctgatg gttattgatg agcaatgttt catatacttg 2880 ttggttattt gtatatctcc ttttgagaaa tgtctattca ggtcttttgc tcatttttta 2940 aatatggttt tttaattttt ttattttttt gctattgagt tgtttgacat ccttaaacat 3000 tttggaaatt aacctcttat tagatgtata gtttgcaaat attttatccg attctgtaga 3060 ttctgtcttc agtctgttga atttgctgtg cagagaagca ttttattttg atgtaatccc 3120 tttgtctatt tttgcttttg ttacctttgc ttttgaagtc atatccaaaa aatcattgcc 3180 cagatcagca gtccccaacc tttttggtac caaggactgg tttcatcgaa gacaattttt 3240 ccatccacag gagggagggg atggtttcag gatatttcaa gcgcattaca tttattgtgc 3300 actttgtttc tattattatt acattgtaat atatagtgaa ataattatac aattcaccat 3360 aatgtagaat cactgggagc cctgagcttg ttttcctgaa acttgagggt cctatctggg 3420 agtgatggga gacagtgaca gttcataagg cattaggttc ttctaaggag catacaacct 3480 agatcccttg catgcgcaat tcacagtagg ttttgcgctg ctatgagaat ctaatgccac 3540 cgttgatgtg tcaggaggtg gagctcaggt ggtaacgtga ggaatgggga gcagctgtaa 3600 agaaaaatga agcttcgctt gcttgcctgc tgctcaccta ctgctttgtg gcctggttcc 3660 taacaggcca tggactggta ctaatctgtg gccctggggt tgggaacctc tagccctgac 3720 caatgttagg gagctttttt cctgtgtttt cttcaagtgg tttcatggtt tggggtctta 3780 catttaagtc tttagtccat tttgagttga tgctgtatgt ggtgagagat aattgactac 3840 tttcattctt ttgcatatgg ttatcagttt tcccaacacc gtttattgaa gagcctgacc 3900 tttccccatt gtgggttctt ggctcttttg tcaaaaatca gttggctata aatatgtggt 3960 tttatttctt gggtctctgt tctgttctat tatctgtgtg tctctttatg ccagtaccgt 4020 gctgttttaa ttactagagt ttagtatatt ttgaagtcag gtagtgtgat gcccctagct 4080 ttgttctttt agctcaacat tgctttggct attcagagtc ttttgtgagg ataatgtttt 4140 caaggttcac ccatgttgtg gcatgtatca gaactcgatt tctttttatg gctgaataat 4200 attccatttg tttatattat atatatgcca tatttattta ttcatatgtt gatggacact 4260 taggttgttt ccaccttttg gctattgtga ataatgctgt tattaacatt ggtgtacaag 4320 aatctgtttg agttcctatt ttcaattctt ttgggaatat acctacgtgt ggacttacta 4380 gatcacatgg taagctttta gtttagcttt ttaaggaact gctaaaactg tttttccatg 4440 ggagcagtgt acaagtgttc cagttctcca tatgctcacc aaaacttaat ttcctttttt 4500 aaaaattata gctatcctag taggtggtgg gaagtggtat cttactgtgg ttttattttg 4560 tatttcttta atgactaatg atgttgagca tcttttaatg tgcttattgg ccattatatg 4620 tcttctttgg gaactgtcta ttaagtcctt tgcccatttt ttaattgagt ttttttttct 4680 gttgaattgt gggagatctt tatatattct gaatattaaa cccttattgg gtgtatgatt 4740 tgcaaataat ttctcccatt ttgtgggttt tcttcacttt ttgatattgt tctttgattc 4800 acttttaaat ttttatagag tccagtttat ctgttttttc ttttattacc tatgcttttg 4860 gcatcatacc taattcccaa atccaatgcc atgaagattt tctgttatgt tttcttttaa 4920 tagttttata gttttacttt ttctattgga gttttaagta aattcttgta tattagtgtg 4980 atacatttta agttattttt gtatatggtg tgaggtaggg gtccaacttc actcttttcc 5040 atatggagat ccagttgtcc cagcaccaca tgtttaagag tctattcttt ccccactgaa 5100 tggacttggc acccttgtca aaaatcaatt ggtggtaaat gtatggattt actcctggaa 5160 tctcaattct attctattgt atttatattt ctgtccttat gcctgtacca cactgttttg 5220 attacagtag ctttgtagta agtttagaaa ttgggaaaca tgagtcctcc aactttgttc 5280 ttcttttcaa gattattttg gctatttggg gtcccttgca attctgatga gtttgaggat 5340 caccttttcc atttctgcag aaaagccttt tgatagggat tgcattgaat ctgtagataa 5400 ctttgggtag tattgacatc ttaacaatat taagtctttc tatgcataaa catgggatat 5460 ctttccattt atttgtgttt tctttaattt ctttcagcag cattctgtag ttttcagagt 5520 acacgttttt cacctccttg gttaaattta ttccttggta ttttattctt ttagctgcta 5580 ttgtaaatgc agttactttc ttagtttcct ttcagattgt tcatttctgg tgtataacaa 5640 cagctgatat ttcaacgttg atgttgtact ctgaaacttt gttgaattta cttattagat 5700 ctagtagctt tctttgagat ttttatatgg gattatgtca tctgtatata gagatagttt 5760 tacttcttcc tttccattat ggatgccttt tatttctttt ccatgtctaa tttctctggc 5820 tagaactttc aatatgatgt tgaaaagcag tggtgaaagt gggtatcttt gtcttgcttc 5880 ctatcttagg tggaaagctt tcagtctttc accattaagt atggtgttag ctgtgggttt 5940 tcataaatgc cctttatcat gttgaggaaa taccctttta ttcctagttt tctgagtttt 6000 tatcatgaaa gggtgttgga ttttgtcaaa tgccttttct gtgtcaattg aaatgatcat 6060 gtatttttcc tcccttatct taatgtaatg tgttatattg attaattttc ttatgttgaa 6120 ccacccttgc ctttctgggg taaatttcag tcacttatgt tatatagtcc tttaaattgt 6180 gttatcttat aacagaatca ctctgctact gttttgagca taggccatag ggaaaagcag 6240 gtaaaaggta atatggcttg aaccaacatt gtagcagcgg aagtggtgag aggaggtcga 6300 attttggctt tgttttgaag atagaaccaa cagtatttgc tgacagatta gatgcagaat 6360 gtgaaaggag gagatgagtc aggatgaatc caaggctttt ggcatgagca accagaaaga 6420 tgaaggtgac ttactaagat gggaaatata caaaaggagc agtttgggga aactttatat 6480 ctattgagtg gaatatgcca attagagatt caaatatcca gtaaataatt ggctatcaaa 6540 gtttgaagtt aagaggaatg gtctaggctg tttatataac tttggaagtc attagtgtat 6600 aacagctaat ttaaaagcca gcagactcta agggagtgag tgtagaggga gaagagtaga 6660 ggtctgtgac ttgaatcctg gaatgctgtg atgtttagag attggggagg taagaaggag 6720 cagcagagta tactgaaaag ggattgttat actgaaaagg gattgatata gatggagact 6780 caagaattat cacagaaacc tgataaaatg tttcaagaag atgggtgtga ttaattgtgt 6840 cacttactgc cggtacattg actcagatga gcgttgagaa ttggctatag gatttgacaa 6900 cataaaagtc attggaaacc ttgacatgag cccttttcgt ggagtggagt ggttacagtg 6960 ggtttaagag aggattaaag gagtggaaac agagatgcta ttatagatga ctcgtttgag 7020 tagttttcct acaaagggga gaataataat ggagcagtta gccaaaagtt gagttttttt 7080 ttcttcttct tttttttagt tggaaaaaat tgcgtatatg ttgatgggtc ttttctggca 7140 gaccagtaga gaggaaaaag ttgatgatgt aggagatggg aaaatgtctt tgagtagatg 7200 tcttcgagaa aatgtctttg agtagatgag aggtttgcac acatggagag gttggatgta 7260 ggagtactga tagttcatcc atagttacat aagaaaaggt agatgtatta gagttctcct 7320 gagaaacaga accaatggga gatctttata tctctgtgtc catctctatc tgtatttctg 7380 tctctgtatc tatgaagaga ttataaaagt tttaagatct gccaggagac atacccacgg 7440 gagctaatgg tatagttcca ggccagttgt gaaggcctga gaaccaggag agcctatggt 7500 gtaagttcca gtctgagtcc aagtctgaag gcaggagaag accaatgtcc cagctcaaag 7560 acaggcagag ggagcagatc ttcccttact tagccttttt atttattcag gccttcaaca 7620 aattgaaggc ccacccacat tagggagggc aatctgcttt actcagtcta ctgaatcaaa 7680 tgttagtctc acccagaaac atcctcacag acacacccag aataatggtt agccaaatat 7740 ctgggcaccc catggcccac tcaaattgac acataaaatt aaccaccaca gtagagtata 7800 tgggtacaaa tataattatg tgatatagat ttcagggtaa gagcctgtgg aaattcattt 7860 ttgattgctt ctagtgaaat cggaagcaag atcatcagct aagagtgacg atcggtggag 7920 gagatatgaa gtttaagtgg agaggagaag gtataaaata gtcttaggag gggaggatag 7980 taaatagatt agggaaaagt tgtaggattg ccaggaagta gtaagggccc acttgaggct 8040 ggtggtcaca aatttaaggt gagaccagtc aaaatggttg tgcttttcac ctgctgcatt 8100 cattcagctg cataggtaca ggcacagagt aggtcaagag ttctttttta ttcggggtta 8160 gagttttgcc aggagatagt aataaagcca gaagggcaat gaatttgagg gagtatgcaa 8220 ggaagtggct gttaacttgg agtttaaact agtcaagaag agaattaagg actgcccaag 8280 gggtgaggac aatgatatgg tagcagggcc cttaaaagcc ccagttagat gaaaagattg 8340 ttggaattga gtttctagag ggaatgaact tgaaaaacag gaggtgttgg ttggagagtg 8400 ggatatatgg aattgagatt atggaaggat tcagtcgttg gtaataacat agtatctttg 8460 taggaataaa taggtggagc aggatgcaga caagatcact ggaggagggc tggtcagaag 8520 actgggaggc actatctccc ttggatatta tacatcaaag cttgtgatct actagacaag 8580 tagtggggaa agggtaggat atagatatta atggctatag ttttgatggt gatggtcatg 8640 gtgatgatga tggtccatta acactcaact caaataccat caatttgatt tatatctaac 8700 accacaaagt taggtgttga gttacatgtg gttatattgt aactaatagt cagcccttca 8760 tggacttcta ttctttgatg agactcttct tgtaggagta gtaggtgcct taaagcacct 8820 tttcatagtt gtcagattga aatccttcac cagtgtttta ggttaaccct gttactgtgg 8880 aagtttctct tggctttctg tgtgggctgc ttctttgtct agttttacct tttggggtta 8940 gcatactatt gtgaataatt tattggtgag aaggtaagca gagaagtaga gtactctatg 9000 acctagtaat ttcatatcta ggaatctatc ctatagaaat gataggaatg ccttacaata 9060 cccacatatc cacaagggta ttcattgaac gttatttttg gtgaaattcg caagcaacct 9120 aattatcatc aatagggaat tgttaaatta tgatagataa aatggaattc tattcagtct 9180 tcaaaaagtc agatcaagaa gtggtcttac attttaatta tcccatcctg tcaacaagag 9240 tgtcttcagt tgcaagtaat ggaaaaacca ttcaaactga cttcagcaat aaaaggttat 9300 ttattggtct gtttcatgga gacatctgag gtagagtggc cttcaggcaa gttcactcag 9360 ggatccgact atttttctgg ccttattctt ggccctcttc tatgaaaaca ccttcagggt 9420 ggtttcttgt atgcttgtaa gatggctact tgcatcaacc atgaccacat ctagcaggag 9480 caaaagcatc ctttcccgta ccagaggaga gtcccgaaat ttgttgcaat tggactgcct 9540 tggaagcaat aattatggcc aggagatgga ggctagagaa ctgagacctg atcatagctc 9600 ctatccttga atcagttgta tagcaagggg aattggattt tccttaagac agttggattt 9660 cacctgtagt cttggtgatg aggtcagttc catccataaa actttgctgt tacacatttt 9720 gggatggggt gaggagggct gaatggagat taggatgcta ttgaaatttg ctgtacacaa 9780 tggatcatta tcgtcttctt tcttagtgtt aaggtaatca gcctcttttt cctcctccta 9840 tgcttgactt tactaaaacc atgagacatg tttaacctca ggactccaat ttgaaaaaat 9900 atagactgtt atttacttta ttacttacag aagcccttca tactactctc agcaagaaag 9960 aggtaggcag ggagtgaggg aggggggatc atgcttactg agaaacaaac tatcgagtat 10020 tgaaactccc ccttcatatg cctgacctca gtcccattca gttaccagta ggggccccta 10080 ttaattggta cctcaccagc ttttgctgtt cgttcataaa actgagtcat tgaagtacag 10140 tagaaaaata attggactac aagataactt atttccttcc ataattgcaa aatatctgat 10200 ttttcttctt gtttgtatta tgtaaactta ccctgtctga gggtcctcct ggattgttct 10260 ttgcatttat atatacatag aatttcattt tcttttttct tgtttttttt ttagacggag 10320 tctcactctg tcgcccaggc tggagtgcag tggcacaatc tcggctcact gcaagctccg 10380 cctcccaggt tcacgccatt ctcctgcctc agcctcccca gcagctggga ctacaggtgc 10440 acgccgccac acccggctaa ttttttgtgt ttttagtaga gacggggttt caccatgata 10500 gccaggatgg tctcaatctc ctgaccttgt tatctgcccg ccttggcttc ccaaagtgct 10560 aggattacag gcgtgagccg cttgcccgac cttctttttt tttttttttt ttttttttga 10620 gacgttgaga tagagtctca ctctgttgcc caggctggag tgcaatggca cgttttcagc 10680 tcactgcaac ctccacctcc caggttcaag cgattctcct gcctcagcct cctgagtagc 10740 tgggattaca ggcgcccgcc accatgctct gctaattttt gtatttttat tagagatggg 10800 gttttaccat ggtggtcagg ctggtctcga actcttgact acgtgatccg cctgcctcgg 10860 cctcccaaag ttctgggatt ataggcgtga gccactgtgc ccggccaatt tcattttcta 10920 ttttgaaatt taaactacca ctgacacttc gttttccctc tgttttactt agcatttatc 10980 ttagagaata atcttaatat gtatagttct attttattct tttactggca gcttagtatg 11040 ccatattttg gatgtgtcat tgtttattta cctattaatt taccctataa ctgcttccca 11100 tatttttgct tttacaaagg gatgtaatga acatccttta catacgtctt tgtgcatatg 11160 tgcaaatatt tccataggat agatgtaatt actgacttga aggttatgca gatttaaaat 11220 tttgatgcct tctatgaaac atctttcaaa atggtgatgc cagtttcttc tctcgtaatt 11280 actgcatatg gtcaatcttt taaatttttg ctggtaatga tatttcaaaa ttataaccag 11340 ttttttggcc tcatttcttg aataacttgt tttttctcaa agataagaaa tgtctccttc 11400 atcgtatgtc aaatttccat atttacatgg atctatttct ggacatggca agttttattt 11460 atttattgta tgtatttacg gtgtacaaca tgatgttttg atacacatat acgtagtgaa 11520 atgattccta cagtcaaaca aattaacatg ttcaccacct tccatagtct ctgcagtctt 11580 caaggttttc tctatatggg attagacatg ctatgtctga tctgtttttg tatttttaca 11640 ccaattccac actaattttt tttttttttt tgactgggag tctcgttctt attgcccagg 11700 ctggagtgca atggcatgat ctctgctcac tgcaacctcc gcctcccagg ttcaagcaat 11760 tctcctgcct cagcctccct agtagatggg attacagcac tcgctgccac acctggctaa 11820 tttttgtatt tttagtagag atggggtttc accatgttgg ccaggctggt ctcgaactcc 11880 tgacctcagg tgatctgccc gcctcggcct ccgaaagtgc tgggattaca ggtgtgagcc 11940 acctcacctg gcacacacta ttttaattac tgtagtttta aaagtttcat atttagtagg 12000 gtgagttttt ccttgttggt cttgtttttc aaaaaaaatt tgctgctctt gagtattttc 12060 tcttcccagt gaactttaat gtaaactcac gtggttcaat gaaaaattct gatgactttt 12120 tttcttggta ttgcttcttg agtgtattga tttaattaat atatttacag ttttgggtct 12180 ggctgtgccg aaacgcagtg tgtcttatcc agtccttttt taactgtctt aataaaattt 12240 gctggttatc tttaaaatgg atcttgtata ttttatgtta ggtttattcc caggcaggtt 12300 gtcatttttg ctgttactga ttttggatat aaattttgga tataattgta taatttggac 12360 ttggatataa ttgtatttga ttctgtctta tatataaaaa tgagatagga taataattta 12420 tcctaggata aaaataattt gagtatcctt attttgcatc tggtacctta cttgctcctg 12480 ttaaacaaat agataaaatt acttgtcttc aaagagatcc tgtggaaaaa ttatttattt 12540 taggagactt tggagctttg ataaaaatta ggcttatctt ttgtaaaagc tggttagtga 12600 tagcaatcag actcttttaa aggtgatttt tttttctttc ctttgataaa atgcttaata 12660 tgagggagga ttaagaaaga ggatggcttt tgaacagttt cttcatgggg aaataagaaa 12720 ttagaataat ttcatgttct ccaaaaaaag gagaaaaatg accttccctc ctgagcctac 12780 ttcaagcctc tgtttctttc tgactctatt gttctcatct ctgcattttt ccaatctctt 12840 ctactgttag tgttttaggc tagctcctca gtggagggca gaaattcacc ttctctttag 12900 ctgtctttga aaccaagaag atagaggtat gagatcttcg tagtctgtag taagaataat 12960 agaagccatc agaaaaaaat atcaaagctt tgtagctgct cctggaagtt ttgatgtgaa 13020 gcaggagaca tcacctattg gtacctgact tgcttttgct gttcattcat aaaacagagt 13080 ctctgaaata cagtagaaaa ataattagac tggaggataa cttttttcct tccaggaatt 13140 acacaatcac aaaattgctg atttttcttc ttattcatgt tacataaact tatcctgtcc 13200 gaaaagactg tatttgaact tactatgtaa gatttgcttt aggtaaattt atggctgctt 13260 ccagaattgt gtattaattt tccagtttct tttttaccag tctccacttt tacctttccc 13320 tcttccccct atacttaaat tggtcttact gtaaaattta tgcgtttctc tttctacctg 13380 gcaatgctga tttttttttt tttttttttt ttgaggcaag gtctcactct ttcacccagg 13440 ctatagtgca gtggcaagat cgtggctcac tgcaacctcg aatccctggg ctcaagcgat 13500 cctcccacct cagtctccca agtagctggg actacagatg tgtgccatcg cacctggctc 13560 atttttgtat tttttgtaga gatagtattc gccatgttgc ctaggctgga ctcaagccag 13620 cctcctgcct tagcctccca aagtgctggg attgctggca cgtaccacta catccagcca 13680 gggctgagtt tctgaatcat cattgcagca agagaaattg gattaccttt agaccactgg 13740 ctctactgtg ggctgggagt gggacacctt ccttaaagcg cattggacat tggctttgtg 13800 ggtaactgat ctttacctga atgaaattta tcagtactgt attaagggtc tagggtggaa 13860 cggatgctag caaggcaacc gttaacatcc acttactgat gaatcctata aaattttatt 13920 tcaggccata cgaagtaaca gtaataaata taaaaggaaa aatagacaac ctaagcaact 13980 ttttaaattg acttacttga aaactttccc tgcaatttcc cggtttataa tggttgattt 14040 cagctgactg gctatagcta cttagagaac agaggaaatt cattaaaaat aatgaattat 14100 tcagttgggt agtgaaatcc agttataaag cacttcgctg tgccatggat tcagttcagg 14160 tcaagtgatg ttcctggttt atgggcagtg tggcttctca ctatgacaca gcaaagaacg 14220 tagcttttat cctttaccct tgttactaac taaaattaat ggcattttat tgtgtttatt 14280 tgtttgattc catttacagt ttatttcact tggttttatt agtacaaaat tgtgctttat 14340 ataatatttg acagttagga aaaattgtta gatacctata aagaaacaag tctctcaaaa 14400 atcatcctac tacttttaaa aattacatcg tcttactaca gttaacctag atgtgaatgg 14460 gtagttttat ttagcttttc tggtttgttt gcttggtctg tttggaggga agttaagatt 14520 agcagaaatg tagtaataga ttcatgaaag tcttgaaagc ttctttaatt agagaattta 14580 atgagggctt tggcatgcat tctttggttt ttctctgttt tcctctaccc cttcttattc 14640 tttttggttc attgaaaagt agaaagaaat tctcaaaaac cgtacaggag aataccttat 14700 aaatgatatc ttctgcaata aactatagat tgtatatatg tatatgtatc tagatacaca 14760 atctgtgtgt gtgtatatat atgcttgtgt gtgtataaat gtataaatta gttactagta 14820 tatacgtaag tataaaacct caatgtgcaa ggttacattt tcagaaaata tgtaatataa 14880 taaaagaaat caagcccaga atttttaaaa agtttattgc gctttctgtt aaaaatgaaa 14940 ggctttttga ctggaagctg cttctcagta aaaataacat aattgtgttg gtgaagccca 15000 aagattctaa tgaaaattag ggtattgaca accaaacgga attgctggag tacttaagct 15060 gctttggttt tgtaatcttt ctgtgtcaga atatttgaaa aacacttatt aatccagtct 15120 tgtaacttat ccttgaaatc tcttttttaa tattcttttc cacacacatg aaaagttaga 15180 tgagtgtatg aatttctgtt gtcagactag ttgtaaacct cctaaatata gtttctgcag 15240 tatagttaaa gagaaagaac atcctggcta acacggtgaa accctgtctc tactaaaaaa 15300 aaaatacaga aaatgagccg ggcatggtgg tgggtgcctg tagtcccagc tactccggag 15360 gctgaggcag gagaatggcg tgaactcagg aggcagagct tgcagtgagc cgagatcacg 15420 ccattgcact ccagcctggg cgacagtgcg agactctgtc tcaaaaaaaa aaaaaaaaaa 15480 aaaaaaaaag aaagaaaata ggcccagcaa ggtagctcac gcctgtaatc tcagcacatt 15540 gggaggctga ggtagggagg attgcttgag gccaggagtt caagaccagc ctgggcaaca 15600 tggtgaaact ccatttctac aaaaaataca aaaattagct gggcatggtg gcatgtgcct 15660 gtagtcccag ctacttggga ggctgagtgg gaggattgct taagcctggg gaggttgagg 15720 ctgcagtgag ctgtgactga gcaacagagc tagactctgt ctcaaaaaaa aaaaaaaaag 15780 agatgggttt tgaaattcag tacttttttt gagtgaggtc caatgggtca gaaagaagca 15840 ttggataaat gaatccattt tctcttctct gtttgaattt gtaatttgaa agaatattct 15900 acctataaag tacttcagtg cttaattagc tgtcagtgaa tttatatatc ttatctaatt 15960 catatggatt tgctattttt atctgtacct acagattcct gacctctcta aggggatccc 16020 agtatactat agggaatgag gtataataga agtaaaagac ctatcactag tcctgtcatc 16080 attccaactc atgtgtaatt atagtttaaa agaagtgaca tcatgtgtat tgctgtttat 16140 ctttacatta atcttgtggt caagaaagca aatactataa tatataataa ttatataata 16200 tcataagaca agtaatataa taatgggaat ataatcccat tttacaaatg aggaaatgaa 16260 aatttagaga aataaagtga cttgtccagg gtcacatgga tactaagtga ccaagtgtca 16320 aagcagaatt ttccaaataa cttaaagata attcttgtac aaatatagaa cgaacacatg 16380 tcatatgtgt tgtgttaatg agggaaccag aaggatgaca acattggttc agagagatgc 16440 aaagataaat atagacattg gaggaaaaag ttggaaataa gattgttagg ttagatacaa 16500 agctgtgtta taggccaata aaaaccatag actttgaggt tatctttttt actggacagg 16560 attcagttac acctttatga gaccaaaatt tattatttaa catgtggata ttagagtctg 16620 agttttaaaa ttattagtaa atgaccgtca aataaagata tgtcccctaa tgaaatactg 16680 ataatcgctg ggtgagcttg tgctcctata tgacattgaa atgacatact gccctctctt 16740 tgtcttctaa gttttggata cttttttttt tttttttttg acacaaagct gcattagaac 16800 ctaggtttct tgattttcag tccagatttc tttccactct acttcctgct tcttcatagt 16860 ataattttca acactagagc agtctgcata acttttgcaa aatcagctag tctttcttat 16920 tagttttcct ttgtgcaaag tgatgtagat acagctttct tcttcagaga aacattgtga 16980 aattcaatga atatttgtaa aatttgcata cgtgcccaat gtgagaaatt gaaattatta 17040 cttaagtatt gcaactgttc ttttaggata ttttgtttgc aaatttcaga gtaattataa 17100 atattcttgc atttttattg taatcagtat ttataaaaca gtgtatttca tcacattaac 17160 ctttacatat tttgaataaa atagtattga accattttaa atagtaagtg gaaatttttc 17220 cacattaaac agtataacgg gctaacagag ttaagcattg cattatttaa ctaataattt 17280 tttcctgaac ttcagattat tatctgtatg tgtcatataa cttgacaatt tttttttttt 17340 agtgcttttt aaaaagagtg ggatacttta ttcagtttag ccctcaagca attaggcaag 17400 tcagttacca tggtaacagt aggtattaat ttccttacct agttagaggt tttatgaaca 17460 aagaaatctc tgagttcatc caccaaaacc caactttctc ttgagactgg cctcttgaga 17520 ctggtgttaa atttgtctat tttctagaag atgacactat tctaagtgga aaatacggtt 17580 ctcttgaggt gaatttctac tctatcaaga gtgaagtaga gtatggctta aaagttaagt 17640 gattaaaaag ctaccctttc ttagctaatt tggaatgtaa ttggtcttaa tttttctaaa 17700 ttcgttctaa ccaaaatctt attggcgtga tttctattga catgaactag aagtgacttc 17760 agcagacaac ttgtcccaat atctaaatgc tgtcaaatag aatcacttaa gatgaatttc 17820 ttccaaaaca gagttcacaa ttttgacaga taatctctta gcatttaatt gactagtatt 17880 accaacctta tggaataggt ccactcgttt agctatcatg aggaccattt tgcaactaac 17940 ttatcaaaaa gccttcacca agaagttgca tatcttattg atattttaga atgcgattat 18000 ggagattaaa aatcaccaca atgggttgtt aataacgcca gccttgaact ttcagtttta 18060 gagcatttta tctgtgttct gtagtcaaag ttggtaaggt gtccagtggg tcatgtttga 18120 cttgctgctt gtttttgtac tgtgtgctaa atggtttcta catttttcag tggttgaaaa 18180 gtcaaaagaa gaataatatt ttatgaaatt taaataaatc caggtttcag tgtctatagg 18240 taaaatttca ttgtaacgtt gttatgctta agtattgttt atgacttctt tgctatagtg 18300 acaaacttga gtagttttga caaagatcat ctggcctgta aggcctagaa tagttactgt 18360 ctaacccttt agagaaaaaa attgctggcc cttgttctat agtatgaaaa aatatagcct 18420 tgattattca ttaaaaaatt attttcccat tttattgaca tacttttgtc ccctgattgt 18480 taaaaggaat gcatgttctt atagaaaagt tggaatatat agaaaagtat aaagaacaat 18540 atgaaaaacc atttgcaatt gtgagataac cactaatgtt ttggtataca ttgctccaga 18600 cttacacaca aacacacacg cgtatttatt ttatacaatt agagtctaat tttttttttg 18660 agacagtctt gctctgttgc ccagggtgga gtgcagtggc aagatttcag ctcactgcaa 18720 cctctgcctc ctgggctcaa gtgattcttg tgcctcagcc tcttgagtaa ctgggattac 18780 aggcgtgcac caccatgtcc agctaatttt tgtattttta gtagagacgg ggtttcgcca 18840 tatgcccagg ctggtctcga acccctggcc tcaaatcatc ggcctgcctt ggcctcccaa 18900 agtactggga ttacacacgt gagccactgc gccttaattt tttaatttgc ttttttcact 18960 tgaataatta taagaacatt atttttaatg actgtgtagt gttctgtttt atggatgtac 19020 catacttaat tatttagtca taatttatta ttatgaggtt gataaacatg ataatcagat 19080 tgagctcaag aagctagtta tagggttgca caattaatga atcccaggta cctcgctggg 19140 ttgctgaggc tgctattttt ttcctgcctg tttggaacac tgtgtttggg accaatgagg 19200 caaaagaaat tgaagagctg ccattttcaa ttattctatt agaagataca ttgaagattt 19260 gtcaaatgac atagacacaa cactaatcca gaagattatt taatcaaaaa ggcattcatt 19320 tcagatatga attcataaac atttgtaacg atcctcagtt tgaagaccat atagaatccc 19380 tgaagaactg gaagacacta tttgcttggc aaagagaagt ccccagacca actggggatg 19440 aaatattcaa agagataaat gaatactttg aaacatacaa ggtactatgg aaaaagagtg 19500 gaagtttggg acaggtaatg acaggaagat ataaaagctt tacattaagt tcaatctaaa 19560 actttattcc aagtaacagg ttgtcttatt catggagaag cagttgtaaa ttaaaacttg 19620 cctgtggttt ggaatttcac attaaatgat tacattaaaa attcaaatgg tgaacctaac 19680 taaatccaag ctcctacagt accttctttt cacctttagg tgaagaaatg cggtgagcta 19740 ttttattact gattatgtgg acagtccaaa ggaaggttca taagcgaaaa ggaaaaattt 19800 aaattattcc atgtgagcga ttcttacttt gcagatttgt tgaagtgtag ttactggctt 19860 caaaaagtgg tatccttaac tgacattttg aacacttgaa ttcactcaat aaaaaaatgc 19920 agtgatcatg tggaaaatac attaaggtat atgacagagt ttatggattc agagcaaaaa 19980 ttcagctttg gaaaagtgaa gttaaaatgg ttttttaagt gatgtttaat tggtgttatt 20040 tgaatcctaa agaagaatta atagtactag tagaggaaag tcagtgtgtc tgtgacaaag 20100 ctttagtatt attttgaaat acttgatata aaaaagttca cgtttactca aagcttactt 20160 aaatcatcag aataaattaa catgtttctt aattaaagaa aaggagaagc tattagactt 20220 aaaaaatttt tgcacccttg aaatacatac aatttgaaga gattaagttg ttggaatact 20280 ggttaatggt gaaaaaggag ttttcagtct atgaaagcaa agccttctcc tttgccattt 20340 gcttttttgt agtggttgct atgtagaatt cgaagaaaat attgttaaaa agtcttggtc 20400 aggagtagag tgtagcatga acccaatgca ttttaacgtt aataatgagg aaaaagggaa 20460 tgcatgataa tttcatcaag tcagaaaaaa atggaaaaag aaaaagagga aactgaagaa 20520 agtaactgat gaaagtaagg tgaaagggaa aacaactttt tataccacct gtgaatgaga 20580 ttaattttcg tttccatact gaaagacaaa tatattccaa ttaagccatt caaaataaaa 20640 aacaattttt ttttggtaag agatgggatc tcactatgtt gaccaagtta gtcttgaact 20700 cctgccctca atcagtcctc ctgcttcagc ctcccaaagt gctaggattt caggcatgag 20760 ccactgtgcc tggccaaaac caaaattaag caacaaaaca acaacaacaa aaattccaga 20820 cagcctttaa aataatgata aaggttgaaa aattgtagat agtggtaggt agataagatt 20880 tcaggaaaag tccaaagcaa atcataatac gttattttaa aggggggttt aaaatccttt 20940 aaaggtacaa tgtgaagcat tatgaaatga taaaatacat gttttttaaa aacattaatt 21000 ttattttaag ttccaggata catgtgcagg acgtgcaggt ttgctacata ggtaaatgtg 21060 tgccatggtg gtttgctgca cctatcaatc tgtcacctac atattaagcc ccgcatacat 21120 tagctgtttt tcctgatgct gtccctcctc caggacccag tgtgtgttgt tccccatgta 21180 ttctcatcgt tcggctccca cttataagtg agaacatgtg gtatttggtt ttctgttcct 21240 ttgttagttt gctgaggata atggattcca gttccatcca tgtccctgca aagtacatga 21300 tcgtgttcct ttttatggct gcatagtatt ccattttata tgtaccacat tttctttatc 21360 tagtctatca ttgatgggca tttggttttt ttccatgtct ttgctattgt gaatagtgct 21420 gcagtgaaca tgaacatgtg tgtgcttgta tctttataat aaaatgattt atattccttt 21480 gggtatatac ccagtaatat aattgtataa cccagtaata ggattgcagt gtcaaatggt 21540 atttctggtt ctaggtcttt gaggaatcgc cacactgtct tccacaatgg ttgaactagt 21600 ttacattccc accaacagtg taaaagcatt cctatttctc catagccttg ccagcacctg 21660 ttgtttcttg attttttaat aaacgccatt ctgactggca tgagagggta tatcattgtg 21720 gttttgattt gtatacaaaa aagatttgta tttctctact gatcagtgat gttgagcttt 21780 ttttcatgtt tgatggttgc ataaatgtct ttttttgaga agtgtctgtt catgtcctct 21840 gcctactttt taatgggatt gtttgttttt tttttcttgt aaatttgttt gagttccttg 21900 tagattctgg atatagacct ttgtcagctg gatagattgc aaaaattttc tcccattctg 21960 taggttgtct gttcactctg atttgctgtg cagaagctaa aagacatgat tttagaaaaa 22020 gacatgtcaa agtcatacat gctcaacgac atagcgagta catatgtaaa taaaaaatta 22080 ttttatgctg tgaatttgac cgaaaataac ctttacctcg tcaggaatta caatcctcac 22140 gtatggtaaa ggatttccct attgcaaatt attccacaac attaatgttc tgtgtgcttt 22200 ttatctatcc caagatacaa gtaaatttga caaagatatt aggtttgtaa acaaatttac 22260 gttcaaatct ttgcctggaa gtatctagat agaattttgc atgcaaaaga gtatttacat 22320 ctaaaaaatt acatatttca aattaaaatg attttagtgt tatagataga aggaaagagt 22380 tattgaagtt tatttctgtt ttggcagtgt aaatgaatta cttacaaaat tttagaagtc 22440 tacaggtgtt tttataaagt ttgtgttatt tgtggaaacc tcagttttct ggcattttgc 22500 caatgaggtc tactctaagt atagcagaaa tttgttttcc agctttataa atatatattt 22560 taagattaag aactgatttt acttatataa tctgggatca acttttggct tctcctgtca 22620 aggattttga atttgtgaca aaatatacac ttattgataa ccagtgacat atataaaatg 22680 ctttacaatt aataaagcat atgtatttta catatttttt cactacatat gacgcatgtg 22740 gcaaccccaa gagttgagtt gtacccatcg gcaaactttg atcatgattc tgtgaatata 22800 ggcaagcacc aattgcaggt agaacattct ttttttgagt cccaaaccgt gagaaacaaa 22860 ttacagaaat gtacctttct tttgcattag gacacgttgt agttttgtat gaacactcta 22920 gttttaagca gtatgtgcaa aaacattgca caaaggattt gtgtgttgat tttgggactc 22980 ctgtattatt aattatgtgg tttatttgac taccccacat tttcaagcat aaattaataa 23040 atccataatt ccaggcttat taacaataaa caatctagat agttgaactc tttcttgcta 23100 acattttcta gatatggact gtttggtatt tttctactaa taaagaccct tagtaagctg 23160 ccttctggtt tgatgtcatt gggatgttta ctgggaactt tggtggagat cttgcagtct 23220 ctctccccca gtggtgaaag aatgagttac aaaccagctt tccttcccag tgtacaatag 23280 cgatggagtt tgttctatat ggaaaatttg tttgataaaa gtattcttta aaattttttg 23340 ttccataaat tatcagtatt ttcagtttct gattcatgct tgggatagtt gctgcatatt 23400 gtttaatttt gtcagaattt atattgttaa atatcaaata cgacagacta ccctcaaatc 23460 ataagtagtt aatgtaatta acatcctgtt tcatcatgag actcttcagt gttacattaa 23520 aaactgctac ctcctgggcc gggcgtggtg gctcatgcct gtaatcccag cactttggga 23580 ggctgaggtg ggcgatcgga tcacgaggtc aggagattga gaccatcctg gctaacatgg 23640 tgaaaccccg tcgctactaa aacatgcaaa aaattagccg ggcttggtgg cgggcgcctg 23700 tagtcccagc tactcaggag gctgaggcag gagaatggca tgaacccagg aggcagatct 23760 tgcagagagc tgagatcgtg ccactgcact ccagcctggg cgacacagca agactccgtc 23820 tcaaaacaaa aaacaaaaaa caaaaaaact gctacctcct tattacaaat aggaactaaa 23880 gttgaagttt gaggaatttg ctaagaacta agccttgaac taaggctatt ttatttgagt 23940 atgagtcata tcagggtacg gatccatttt actattaaca aaacaaatat gttctgtttt 24000 ttttttttaa atgcacacac cacgtttgag agattcttat tcactgtatt ttctttaatt 24060 atacttgaat tttggtttac attgaggagt gccctcaaag atattaacag atttttaaaa 24120 aatcctctaa aaaactcatt cttagggaaa tttgttcact tactaggtga ggagcaaaat 24180 aaaaatcctt aatatagaag agctattatc tgtcttcaaa attaagtctt tgagtagatt 24240 tgtgaataaa tctaatagtt ttgctgaatt tacttagatc ttaagacaga ataatcatgt 24300 agaaaattta aaatgtcagg aattcataat gattcatata cccaaggatt ttcattgata 24360 gtgaggtaag gttattcttg agaaagactc aaagtcataa aataatagaa tttcgaaact 24420 accagaatta tacaagtcaa ttaaaatgac tgatttgttt taagaggaag aaatactaaa 24480 tgtataatta ttagatgcag catattgtat ctgttttgtt ttgtgattct agctcttata 24540 acctatgctt ggacctaggt gtcataactt actttaaata tgtatgtttg gttttcattc 24600 atattgacag tactacctct cagttttctt tcagatattg ttttgtattt acccatgaag 24660 acattgtttt ttggactctg caaataggac atttcaaaga tgagtgaaaa aaaattggaa 24720 acaactgcac agcagcggaa atgtcctgaa tggatgaatg tgcagaataa aagatgtgct 24780 gtagaagaaa gaaaggtatg ttgttcattg actattcttt tgggtgagaa atttaattta 24840 tatttgactg tgcaaagagt cagttgttac ttgtaaactt caagtcattg tttaggtcag 24900 agttgctgtt gtctaaatgc accaggacct agttgttgaa agggtaaact ggaataaact 24960 ttaattgggt ttacaaaatg agaattctta ctgtatattt tctctttttc gggttgactt 25020 taccagtttg ttctagttca gataatttag acaacattaa ctttgttgaa ttttttgttt 25080 gccagccggt cttcagcatt ttaaggcaac attattatta cagttgtaat acgaatataa 25140 ttaccagaga aaaaactcag gaaaataaat gcttttatga aaatgggatt agaggtttga 25200 aaataaactt gttaggagaa ataatttcac aatgggatgg ttttttcttt gttaagtttt 25260 ctttatgact tcattagttt ataaaacatt aattgataaa acttagaact ataaattgaa 25320 tgcttcagtg aactttatta tttcagtgaa catttgttat ttgatgtgaa ctttgtgcct 25380 gttttgaaat ttactaaact caaggcatgt gttcggaaga gtgtttttga agatgacctc 25440 cccttcttag aattcactgg atccattgtg tatagttacg atgctagtga ttgctctttc 25500 ctgtcagaag atattaggta agtgatttga atttcctgat tttatttgaa tttggaccct 25560 tagaaggtac tattatggta atgtttgtga atatactgag ttttacaggt gaggtgtgtt 25620 caatagataa ttatttctat gtatacacta tcaccaagtt ttacatttca aataaaagtc 25680 actgaattaa tttgtaatct gtcagtttgt tcattcataa gcttttctat tacttcagac 25740 agtttttttt taactttttt aatatatgtg ctgctgaagc gagcacgaca gttttttaac 25800 tttcagtact taagatgtta tatatagagc tactgaacat actgtgttta ttttaccaat 25860 ttagggaaaa agtgcaaaaa ttatttaacc tttaaatgca cctttatatt tcattaaaaa 25920 tatcaacata gtaatattga ataatggcta tgatcggctc tgttgtgtgt aattagtaac 25980 agttgtagca aatgatcctt aaaaaatgtt ctaactaaac attagaggcc aggcgcggtg 26040 gctcaggcct gtaatcccag cactttgtga ggccgaggca ggtggatcac aaggtcagga 26100 gattgagacc atcccggcta acatggtgaa acaccgtctc tactaaaaat acaaaaaatt 26160 agccaggtgt ggtggcgtgc gcctgtagtc tcagctactc aggaggctga agcaggagaa 26220 tcgcttgaac ctgggaggca gaggttgcgg tgagccaaga ttgcatcact gcactccagc 26280 ctgggcgaca gagtgaggct ccgtctcaaa aaaaaaaaat ccaaaaaaac aaccccacaa 26340 acaaacaaaa aacattagaa atgtctgtta gtacttttaa aggttgcctt gtaaaattag 26400 gactgcaata gtgcaatcta aggctctcaa agcataaaac aagtaataag gaattcattc 26460 agatattttc cgaggtggtt atacctgtct tttaaaaaaa aaattttgtt atatattggg 26520 ttaaaaaaag cagaggtgct gggcacagtg gctcatgcct ataaccccta cactttggga 26580 ggccaaggca ggaggattgc ttgagcccag gagtttgaga ccagccatag taagaccccc 26640 atctctacaa aaaaatttaa aaattagcca ggtgtctgtg gtcccagcta ctcaggaggc 26700 ctaggttttg ggcccgagag gttgaggctg cagtgagcct tgatcacacc attgcactcc 26760 agcctgggca acagggcaaa accctgtctc aaacagacaa acaaacaaac aaaaggcaga 26820 ggtaggttaa gctatttatt aatggtcttc tactggtata gatataagct agaaataaca 26880 ttcaagtgtt tttactttta ctacagttat ctggccactt tgggactcat tatactgaat 26940 tagtttcaca gaggaggtaa aatctgttgt ttatgattac atattaactc taccatttta 27000 ccttcagcat tgctgtagta tgtcatatct gaaggcaatt agcacaagtg acttgaagaa 27060 ttgtagtttt gatgacttat atgtatttta taaaaggcag gcagagtttt tgtgtttgct 27120 ttcccctcct ctggacactt taaatttttg ctaccacagg tttccaacaa tttgattatg 27180 atgtgccctt gtgtaatgtg gttggtgttt atttggcttg gagttcgttg aatttttttg 27240 atctgtgtgg gcttatacct ttaatcaaat ttgaaaaatg tcttcagatc ctttttcctc 27300 ccatcctgtt attcttttct ctttctggga ctcttagtac acacaagttt gattgcttga 27360 tactgtgtca caggccactg aggctctttc ctttcagtct tttcttcttt cttccttttt 27420 ttctttctgt gcttcatttt gaatagcttg aatagttttg tttcctgtct tcaagttcac 27480 ttatattttt ttcttctgta gtgtctggtc tgtttatacc atcctgtgaa tttctttttt 27540 agatactaca tattttgttt atctctagaa gtcccatttg gttcttaatt tttttttcca 27600 ttttggctct cattattcat gtttctttca aaattcttga acatatttag catattttta 27660 atagctgttt taatgtactt gtctgttaat tccattattc tagggttttt ttctttctat 27720 tggatgattt ttctcctgat tatgggttat attttcctgt ttattcctac agctgttaat 27780 tttttttttt ttaattaggc attgtgatct tactttgtgg aatgttagat tttattgttt 27840 tcctttaaag aaaggaactt tgtcagacat ctaagttacc tgaagatcaa ctttatgttt 27900 tgaagcttgt tttcaagctt gatcagggaa agtctacgtt tgcctttagt ctaaaggtaa 27960 tttagcccta taataagatg tgacccttct ggagtctttg tagactgcct ctggtgatca 28020 acgatctctt ctctgacttt tcagaacgtt aatgcctctt acctttgtgt aagtccgtcc 28080 taagaatcat tcagcttatg gttgtttgcc cagccccata gagttttagt ctatgcatgc 28140 ttgtcttcgt attctgcaaa gaccaaagga gtcccttagg gagatttctg gagctctttt 28200 cctgcctagc ttcctcctct ccagaactct gccccgtgag ttccaggtcc ttcagcttcc 28260 agggctctga actctgtctc cccaactcag tgctctcctt gggattcttc tccctgttct 28320 gttgtctgca atgggtccca ggaagaatgt ggggcaactg taaggttcac ccttcatttc 28380 ccttccctta gagatcatag tcctgtactg cctgttgtct agtatctgaa acagttgttt 28440 tatatgtttt gtccaagttt agatttgttt gtggtgggag ggtgagtctg gcctcccttg 28500 ttatatcatg ttggcctgaa gcagaagctg agtttctttt attttttaaa tatagtttca 28560 atttttaaca actattaaat aggcaagtat caacaacaat agataacaat ataatagata 28620 tgcatattcc tcccacttta tcaaatctta attttcttca attttttttt ttttttttaa 28680 tagggtctca ctctgttgct cgtgctggag tgacagtggt gtgatcttgg ttcgctgcaa 28740 cctccgcctc ttgggctcaa gtgatcctcc tgcctcagcc tcctgagtag ctgggactac 28800 aggcatgcac catcatgccc agataattta tatatatatt tttttataga gatggggttt 28860 ttgccatgtt gcccaggcgg tctcaaattc ctggactcaa gcaatctgcc tgccttggcc 28920 ccccaaagtg ctgggattac aggcgtgaac cactgcgcct ggcctgtttt cttcagttct 28980 ttattaagaa atgaaacagt aaaatacagc tgaagccccg tgtttgttct ttctgattct 29040 ccctctgtgc ccctctgaga taacttctat gagttttgtg catttttttt tctttttaat 29100 aaaaacaggg tcttgctctg ttatccaggc tggagtgcgg tggcgagatc atactcaatg 29160 cagcctcaac cttatgggct cgagtgatcc tttcgcctca gcctctcaag tagctacaac 29220 tactggtgtg tgctgccatg cctggctaat tttttattta tagtttttaa agacagggtc 29280 tcactatgtt gcccaggcta gttttgaact cctggcttct agtgatcctc ctgccttggt 29340 ctcttactta aagcactggg attacaggtg tgagccactg gctgctcaca tgttttttat 29400 aatagtactt aataatttta tgtctgaaaa tattatataa tgttattttg cccatttaaa 29460 aactttaaaa aatgctaaca aactgtgtac tctgtaactt gtctttttta ctcaacacta 29520 cgtttttgag aatttttctt gttgatctgt gtagttccat tttaactgtt atatcttact 29580 atgtttcatt atgcaacagt tggttcaatc cattctcttg ttaatggaaa tttagtttgt 29640 ttctaatttt tgccagtagg aacagtgttg caatgcatat tcttaaacat gtctgtacac 29700 atctgagggt ttcatttatt tgtgacaaaa cttgccaggt catagtgttt atgcaccttc 29760 aactagatat tgtcgttgtc aaagtttttt tccaaaagga ttttaccaat ttatacatga 29820 accaccgata gatatcctct taacacgtgg tattctgaaa cttaattttt accaatcaga 29880 tagatgtgaa atcacgtaga cttagtttgc atttctttga cttctagtga gaagtagtgt 29940 cttcacatat tttttggatt tttaaaattt attttttatt tttgtttttc ttagagacag 30000 ggtcttgaac ttttacccag gctgaagtgc agtgatgcga tcatagctca cgctaacctc 30060 gaactcctgg actcaagtga tcctcctgcc tcagcttcct gagtagctgg gactacaggt 30120 gtgtgccacc aagcccagct aatttttaat tttttttttt gtagagacat gctgtgttgc 30180 acaggttggt cttaaactcc tagtctcaag cagtcctcct gccttgactt tccaaagtgc 30240 tgggattaca ggggtaaacc accatacctg gccatatctt ttggatttat tggtcatttg 30300 gattttcttt tgggaattac ctgttcatat ttttctccat ttttctgctg aataatttgt 30360 cttttcttac ttatttttca agaaatttta catattttct ggctgttcat tgtcagttgt 30420 atgtgctcca gataacttga acagtctgtg gttgcctttt aatttttgaa ttatgtcttt 30480 agttatgcag aagtttaaaa ttttaacata aattaattta cactattttt ctcactttag 30540 catgagtcta tcagatgggg atgtggtggg atttgacatg gagtggccac cattatacaa 30600 tagagggaaa cttggcaaag ttgcactaat tcagttgtgt gtttctgaga gcaaatgtta 30660 cttgttccac gtttcttcca tgtcaggttg gtatctctac atttcatttt tatatggctg 30720 ataattgtaa tatgtcaact ttatccctat aaaattaagt tcttttatta gctggccgtt 30780 ctctcattat ctcaaattta tttaagtatt tatgttctac ctgattcact cacattcctt 30840 gttttattta attttcacaa catacctgtg aggcattgac attttttctg ttttagagaa 30900 gagaaaactg aaattttaag aggctaaatg accaggatat gtactgctat tgctagcagg 30960 agtggcattc aaactgatta ttttttcttg tcatttatca atcaggactg tttgctttag 31020 ttaagaaata ctcaaggtca atgtgtttct gaatttaaaa ttactgttaa atacaaattt 31080 acacataaac atggtatgta taagaagtag gacataaatc catcatactt gacagaactt 31140 atggaaataa caagaaaatg ttacagtttt tccccaggga ttaaaaatgt tgcttgaaaa 31200 taaagcagtt aaaaaggcag gtgtaggaat tgaaggagat cagtggaaac ttctacgtga 31260 ctttgatatc aaattgaaga attttgtgga gttgacagat gttgccaata aaaaggtaaa 31320 agcaatatat atataatttt catgatgaag attattttgt gttacacaga atgtactttc 31380 tatctgaatg ttagattttt ttttgaaaaa gcttgttata taatgttttt gtagcaataa 31440 aaaagttcca agtgaatgtt ctttaatgaa aacctttatt tatttattta tttttaactt 31500 ttgtttcaag atcggggtac atgtgcatgt ttgttacaca ggtaaacttg tgtcatgggg 31560 gtttatcata cagattattt tatcacccgg gtattaagcc tggtacccat tagttatttt 31620 tcctgatttt cttcctccct cctcccaccc tccacctccc acagtgtgtg ttgttcccct 31680 ctgtgtgtcc atgttttctt atcatttagc tcccacttat aagtgagaac atatggtatt 31740 tggttttctg ttcctgcgtt agtttgctaa ggataatggc ctccagtgcc atccatgtcc 31800 ctgcaaagga catgatctta tttatttttt ttatggctgc atagtattcc atggtgtata 31860 tgtaccacat tttttttaat gcagtctatc attgatgggc atttaggctg attccatgtc 31920 tttgctattg ttaaatagtg ctgcagtgaa catatgcgtg catgtgtctt tgtaacagaa 31980 tgatttatat tccttttggt atatacccag taatgggatt gctggggcaa atggtatttc 32040 tttctttagg tctttgagga attgctacac agttttccac aatggaaagc ctttagttct 32100 aatccatgtc ttggcataga gtttcttttc tttttttttt tttttttgag gtggagtttc 32160 gctcttgttg cccaggctgg agtggaatgg tgtgatctca gctcactgca acctccacct 32220 cctgggttta agtggttctc ctgcctcagg ctcctgagta gctggggtta caggcatgca 32280 ccaccatgcc tagctaattt tgtattttta gtagagacgg ggtttctcca tcttggtcag 32340 gctgatctcg aactcctgac ctcagataat ctgcctgcct cggcctccca aagtgctgag 32400 attgcaggcg tgagccaccg cacctggccg gcagacagtt tctttttttc tttttgagac 32460 agagtcttgc tctgtcgccc aggctggagt gcagtggtgc aatcttggct cactgaaacc 32520 tctgcctcct gggttcaagc gattctcctg cctcagcctc ccgagtagct ggcactacag 32580 gcgtgccacc acacccagct aattttttgt atttttttta gtagagacga ggtttcaccg 32640 tgttagccag gatggtcttg atctcctgac ctcatgatcc acctgcctcg gtctcccaaa 32700 gtgctgggat tacatacagt ttctttaagc aagccttctc ttttccttcc tcccagttct 32760 tggtactctt tcactttcat atatttgcaa atgtaaaatt gtgttttagg tgtatatttt 32820 taatccatgt ataccagtaa cttaaaaaaa aatttttttt tttttaaggg agagcataat 32880 ggagctcttg tgatacggtg ctcttagtgg aagtttggct atcaattcca tcacctgtat 32940 ttcacatatt ttattaatga agttcttaaa ttaaattctc atatttagcc aagtattcat 33000 ttggctggga ggtagaaagc ctactaacca actttttttc atgaacaata tttttaaagt 33060 ccaagatttt taatacctac attagggaaa ttctagaatt aaattcttac aatgtggact 33120 gcatatgagg cttttagtga cagggaattt gttgaaggct atctgtgggt tgtattttgg 33180 tataacattt cctaatttta tttgtggtat gttcatttga tatcatttgg taatacctga 33240 aaacaggaac tgattttact gtgttgcttt ttcatcattt ctagctgaaa tgcacagaga 33300 cctggagcct taacagtctg gttaaacacc tcttaggtaa acagctcctg aaagacaagt 33360 ctatccgctg tagcaattgg agtaaatttc ctctcactga ggaccagaaa ctgtatgcag 33420 ccactgatgc ttatgtacgt gcttaaagat ctttagaaat tgtgatgtgt tttaaaaaca 33480 ttattataaa tgactttaga aaaattttat tatagtagtg gcagaaactc taccaaaata 33540 ttttatatca atttggcatt gaaaaatgct taggaagaca tttagtgaaa ctattcattt 33600 tcgatattaa ttagcaagta ccaatcaaca gattgttcaa tgctagttta ttttcattgt 33660 catgaagcca aattaatgtc taatttgtat gttaaaaaat gtgaacttgc tgaaaacatg 33720 aaaggctaat aaatccaggc tgagcaagca taaatagtac tgatgatgga tttgatatat 33780 aaacaattca gaatgaaaat aattatagta cagtttctat tttaaaactg gccttatttc 33840 ttatatataa aatgtggtga aattttagaa aaattgcctc caaatttagc ttgttgctgc 33900 cattagatat atttttatat ttacatgttt gtatgtagtg aaatctgggc ttatctttat 33960 atatagcact attgtgtgtt ttttaagaaa tgtattttat tccacagtga atttgttttc 34020 tcctaactca tgctttcatt tgtagatgaa tattttattg tttctccttt gcatctatca 34080 aaggaatgga aactcctttg aattgtaacc agcaaacaat tcacttttgt tagggaaatt 34140 ggatgataat tttcctttaa aagataccgc caaacttgag actaacattc tcagctgatt 34200 taagtaggat ttctcttact agattgcatt ttgttagatt ccattttaag ttattttatt 34260 tggatattgt gtgtaatatt gagtgtgaaa aagtgaaaac aaacttttaa ggctcaggca 34320 cctttctcaa ttttcacaat tggtatgatt attaaatgag gacatattga tatttgtgtc 34380 acataatagg ttgaattcca tgtttgggtg ctttgtgaat cattctcttc gatttttctg 34440 aagatgggac ttactgtttt atttcggtga tctttagcat actttttaaa tttttctgtt 34500 tttttatagg ctggttttat tatttaccga aatttagaga ttttggatga tactgtgcaa 34560 aggtttgcta taaataaagg tatgttaaga tccataaata aaatgtgaat tcactctttt 34620 gtgaggttta tctccaaaaa aggcaatatt cacatatttg caaagcattt agtactataa 34680 cttcttgaat gtctgagcag tcctgacatt agggtgggat ccatcagggc ccaagatgag 34740 tgtttcatct ttgttacttg tggcaaagca gcccttactt cttttacttt gtagcattgc 34800 tatgtatttg gcttctagag ttggggcttt gtggctttct tattgcagtg acacaaccag 34860 ctttctccta gtctggagat tatacatcct tgctataagt atttaaaatg ctttctatat 34920 aatgctttaa aacatgtaag atggcttatc cccaagatgg tagctaataa acactaagtg 34980 ataaagtagg taaagatcta tttattcatt tattaaatat tgttggtcat tttacagtgc 35040 tttctaacat actgatttac atttctaatt ttcttctgtc atttttctcc aaaaataatg 35100 gtcatgtcat ccaacctcag tgctgttttt agaggtcttg ataagccagt gagagcagaa 35160 ggagccacgt agtagagtgg gtgagcccag gctttttgtt gcacagacca atgtgaatcc 35220 cagccatgtg acctgggatg tacctgtttc tccaaacatg gaatgtagat actagcataa 35280 tgtccgtttt accgttttat agaataattg tgaagactta aagggacaaa ctattcgaag 35340 catctgtatt gatataaagt tatcactatt ctcgtagctt ccttttggag attttaaatg 35400 attgtgtttg ttaagatgtt aattaaatta ggccattttg ctaaatgctc ttaaaaatat 35460 ggcatgactg cctcatataa aatgatatga tattctttat aattgtcgtt gagcctctgt 35520 gggtggcagg ccctccttta tatgttaagg tagaagagtc tttattctta cttctcctcc 35580 ctggagagcc acttcctatg aatgcctgct ggttctctgt agtcagaggt cttgtggctg 35640 taacttagag tcagtctcca tatccctggg ttctgcatct gtggattcaa ccaaccacag 35700 attgagaaca ttcaagccaa aaaaaaaaat tcacagtttt aaaaaaggaa aagttgaatt 35760 tcttgcatgg agtaccacat tgaatctata tgaatgaagt gatgcgtagg cattttataa 35820 ggtattataa gaaatccgga gatgatttaa agtatacagg acaatgtgta tagattatat 35880 gcaaatattg cagcatttta tataagagac ttgatcatct atggatttga tatcagtggg 35940 agggaggttc ctggaaccaa tccctcaagg atacagagga atgactgtat gttaattaac 36000 tgaggcaggt gatcggtttt ttaagctgat tagggaaaca gtatataaga acttacttaa 36060 ctcataataa aactaaaatt caacagggga gagttatgat tttttggctt tatggttgtg 36120 gaattgcatg taggttacat gtacaatttt gttacatgtg caattttgat gaaaatgctt 36180 ccaaggaatg tttatgatat ttttcactaa agtaacatat attaataaca cagtactgga 36240 agtcctggta tctgtgtact tgtcattgta atgctacatt atttgacctt cacttttttt 36300 cccctttatt acattatatg tgtgagtata ttgtgacatc ttgactcaga ttccagtgaa 36360 ttgtattagg ttggtgcaaa aataattgtg gttttggtaa tttttaatgg caaaaaccac 36420 aattactttt gcaccaacct aataactaag attaccatct ttttttcctt ccttcctccc 36480 ttccttcctt tctgttattc agccagaagt atcagcatca ctgttctctt attttcttca 36540 tgtacatatg gatgatattt tcgaatgacc acttttctct tttgcttttt attattagac 36600 tgtttttttc ttcttgttaa aggataaaaa gattagaaca taaaaggata tttacacatt 36660 gtttccccat tgacttattc ccaagatggt agctaaaaac accaaatgat atagtagtta 36720 aagatacatt gactcattta ttaaatattg ttgagcattt tacgatatgg gaataccgta 36780 gtgaacaagc caggcatact ctgtttcctg aggggcctac agttttattg gggatataga 36840 tgagtgaaga aagcaattgc agtgtaggga gatgagtctt atgtcatggg aaaacaaggt 36900 gctgtagttg acacaccgag aggcatctga cacattgggg gaaatattct agaatatttc 36960 ctggagaaag tgcaggtaaa agccagacct gaaacctgag caagagttag ctaaggccag 37020 gtgcagtggc tcacgcctgt aatcctagca ctttgggagg ccgaggtggg tggatcacct 37080 gaggtcagga gtttgagacc agcctggcca aaatggtgaa acaccatctc tactaaaaat 37140 acaaaaaatt agctgagtgt ggtgacgggc acctgtaatc ccagcttctt gggaggctga 37200 ggcaggagaa tcgctttaat ctgggaggtg gaggttgtag tgagctgaga ttgcaccatt 37260 gcactccagc ctgcacaaga gcgagactct gtctcagaaa aaaaaaaaaa aaaaagttag 37320 ctagctgaag agtataggaa agaatgggta caggaaatta caggtgccaa gttacagagg 37380 tgagagaaat tatggtatct ataggtaatt gaaagtaatt cagtatagtg aacattgaat 37440 agggctgggc ggatgaaggc aaagcagaaa aaggaaagca gatgggccat ggtaaggagt 37500 ttatatctcc tcccaagagc aatcgaagtg actgagagtt ttaaacacag cagtgaagtg 37560 aattacatta aaaaaataag aacttgggct ctagaataaa aaacggatat aggaggaagg 37620 caggagtcac agtaggaata tcttttggga ggctgtgaca ataatccaag tgagaagtaa 37680 tggcaacttg agtcggttaa ttgtgttgag aatggagaga agttgacagg ttcaaaattc 37740 atttttcttc tttttttgag tctcactctg tcacccaggc tggagtgcag tgatgcgatc 37800 ttggcttacc gcagcttcca cctcctgggt tcaagtgatt atcctgcctc agcctcctga 37860 gtaactggga ttacaggtgc ctgccaccac gcccagctaa tttttgtgtg tttagtggag 37920 atgtggtttc gccatgttgg ccaggctggt ctcgaactcc tggtctcaag tcttccgccc 37980 acctcagcct cccaaagtgc tagaattata ggcatgagct accacacctg acctcaaaat 38040 acatttaata gagcaagcat gagccactat gcccagcctc aaaatacatt taataaacca 38100 atggaatttg aggtaatgat gaaagacaca tgtcaaggat cattcctgtg ttgttggcat 38160 aagcaacagg gatgaaaagc attgaggaag agcaagattt tgggatgcgt tgtcacacag 38220 ttgattttag gtatgttaag ggagggagac ctgtaagaca gcaaagtgga ggtggtgcaa 38280 gaattagttg tgttggctgt agcacagagg acagtttgag ttaagagagt tgggactgag 38340 aatcccgagg aactcttagt gttgaacatt tgcgtggagg aggggacacc aaaggagttg 38400 ccatagacat cgaggaaatt aggaggtgtg gtgtgcagaa agccaagtga agaacatgtt 38460 ttaagtagga ggatgctatc aactgtttta aattctgctg agagtttgag aaactgagga 38520 cttagaattc atcattagat ttggcaatgc gccaatcatt tgtaatcttt taaacaatag 38580 ttttgctgta ctgggtagca aaagagtgat ttgaggagtg gtcatttgga gcatatgcta 38640 ttcaaacaga gaagagtcca cgggctttgg taacatgaag gtcctataac catagcaaga 38700 gaatgaggtg ggtggaagtc atattaacgt gaatagagga gtaggttaga tctgaggaat 38760 gtgggaacag agacagggtc tcattatgtt gcccagcctg gctcagactc gtggcctcaa 38820 gcgatcctcc tgcctcagcc tcctgaatac ctcgggtttc aggcctctgc atctggcttg 38880 aaaacaacat tttctcagaa gcttgtttta gttgttttag aaataacgaa ggcatgtgta 38940 aacaactgtt ctagaagctt agtttggaaa gggaacgttt attgatgcat ataacactta 39000 tatgttgggt gcttatgtgt caggcactgt tagagttgct cgggaaaatt tacaaaccaa 39060 gcaaaccatg ccccttcatt tcctttgggt gaagtgaggg agccatgtgg ttatctgaag 39120 gaagagctta gcaggattag agggaagaaa gtgcaaagcc tcctagggtg attggctggc 39180 tcttttggag gaacagtacc tataactgaa tgaaatgagt gagggtaaga gtggcaggaa 39240 atgaggctag aaaaggagct tgggccatat cacgtagggc ctcgtaggct gtgaatctga 39300 cttcatttct tattaatgaa aataaatacg atgatgggtg atgggaaacc catagaggat 39360 ttggagcaga agaatgatat aattaaaatt ttattttaga aatatttttc tggttgtcgt 39420 aagaggaaaa atatttagcc ccagggcatt ttggcagaga gttaggaggc tattgtaaca 39480 gcccaagcaa tagacaataa ttgtttggat taggcgggta gcaatagagg tgatgagaag 39540 tcgtagcttc tgtaggtatt tggaagatat atattgtgaa ggatttgctg atgaattccc 39600 tgtaaggggt gagatgtaaa gattcataga acattaagat attttggtca gatcatctga 39660 tcaatggaaa ggtcagttat agtggacaga ttatgagaag aacaggtttg ggtgagaaaa 39720 ctttagattt cagtgttgga tatcctaagt tttagatgat tattgatatc caagagatat 39780 caatatttgg gatcaatttg ggaaatatga tcccaaagtt caaggttgag gttggagatg 39840 taattcagat ccgatggtag ttaaagcagt gagactgaat gagataaaat agggagtgaa 39900 tgaaataaag agtaggtgtg atattgacct caagggcaca ccagcattta gaggttggga 39960 agatgaggag agagcagcaa agaggactgg gagggccact aatgaaggag ggaagtacag 40020 gaggtgttta gttctgaagc cacctgaaga aaatgtttgg aataggaaga agttgtcagt 40080 tgctttaaat cattcgggga ggttgagtga gatgagagtc tagaactaac agttaggttt 40140 gatggtgtgg aggccatcag taaccttttc tttctttttt ttttttgaga cagagtcttg 40200 ctcagtcacc caggctggag tgcagtggcg cgatctctgc tcactgcaag ctccgcctcc 40260 caggttcaca ctattctcct gcctcagcct ccggagtagc tgggactacg ggtgcccgcc 40320 accatgcccg gctaattttt tttttttttt gtatttttag tagagacggg gtttcaccat 40380 gttagccagg ttggtctcga tctcctgacc tcgtgatcca cccgcctcgg cctcccaaag 40440 tgctgggatt acaggtgtga gccaccgcgc ccggcccaag agtaaccttt tcaaaagcag 40500 ctttgctcta ctgatttggg taaaagctta gttgcagttg gtttgggagg aaatgggagc 40560 agaaaatttg agagagtgag tgtagacaac tctttcaagg aatttcgcta taaatgggag 40620 tagagatctg aagactgaat aattagcaaa ctgaaaagtg ggaagacgta attctcttat 40680 tatttcattt ttcttagtga aataagaggt gaagttctct gagtaatagg agggtcaaac 40740 aggtgttaga agttcacaaa gaaaggaaga ggtttgaaat agtcattttg agagtgggaa 40800 atgtagaaga attaacagtc attgctgagg gtgcgtttga aatctgtcat gagtttaaaa 40860 taacttgtgt catcatcgat gtgtttattt tcaactatat tcaactgctt gggtgtaggc 40920 atcaggtagg taaaaaaagt gggttttatt atgagtagag gttttgccac gtaattacca 40980 tggagggagg gaagagcaaa ggagttgaga gtatagatac aaaggaatga ttactgtaat 41040 gtgggtaaga gaggaatgga aggctcagtg ggcagtggga gtagggatgt tgataggtaa 41100 ggaaaaggtg ataggatcaa tgcatttggt tctgcaagtg tcaaagtatt gttggggaaa 41160 gcatgctgga aggaaagata gggatgctgg tgttctcagg gtggaaggct tacagttgta 41220 gtctggaagt ggtgatttta ttggcaatta taaggtcaac ggtatgacta tggaattgag 41280 tggctaaggt ctgttgaaga aaagattgtc ggaaatgcag gggtcaagga actggcctgt 41340 ggatgttgaa ctcactggca gtgatcaagg aatagtagtg gagtgaaagt agttaatgaa 41400 tcaggcacta agatctccaa gggatgaaag gatgcagttt ggagatgaca agataactgt 41460 agtaatcagg aatagcaggt tttgtagctc tgtctcatag gcctcagagg agatgggctt 41520 ttgaaggaca agagaaatga tgatgaataa attctaagca ggggaagtgt ttgggaaagc 41580 agggcaggct ttgtgctgtt gatggcaaat gatgtaccag acaggatgaa gttgagaatt 41640 tggaagttga tcactgatta gaaaggctta cattttattt tggccggggg tggcagctca 41700 tgcctgtaat cccagcactt tgggaggcca aggtgggcgg atcccttagg ccagaagttg 41760 gagaccagcc tggccaccat tgcgaaacac tgtctctact agaaatacaa aaaaaaaaaa 41820 aattagctgg tcgtggtggc acatgcctgt agtcccagct actccggggg ctagggaatg 41880 agaatagctt gaagccggga ggtggaggtt gcagtgagcc gagattgcgc cactgcattc 41940 cagcctgggt gacagagtga gactctgtct caaaaaaaaa aaaaaggaag ggcttacatt 42000 ttattttggt gctgactggg aatgaaggca atgagggatg actgttggag aaggctgtgc 42060 ttactaaaca gtattattaa gtagcagcat acatggtgtt atactgactt ctgattttgc 42120 aatagtacag acaggttcag attctcattt ccaccttctc cttctgccta ggtgaataac 42180 tgctgggtta tagtacagat gactgcagat catttggaat ttactttaaa tgtaaacagt 42240 aaaaatttga aagagaggga aagtgattga ggcaatttgg ggattgaata agaaggtctt 42300 tttgttggaa ttcatttaag gaaagaaaat gaaaatttga tccctaatat tatttaatga 42360 agtggctaaa tgaatatctc tgctttgtgg tttgaaaatt aatattgatt ttttttcccc 42420 ctagaggaag aaatcctact tagcgacatg aacaaacagt tgacttcaat ctctgaggaa 42480 gtgatggatc tggctaagca tcttcctcat gctttcagta aattggaaaa cccacggagg 42540 ttaaatatta cctttttttt ttttaactta aatcaattct gtttattttt ttatcacatt 42600 ttcctatatg tgaagaatac tattcattaa ggctgactca tagaaatttg cttgaataca 42660 cacacacaga ctgatgcata aatttgagaa atatctttcc agttgttgaa tagtgaatcc 42720 aaaggtttaa gccttttctg tctgctttgt aggatgtttt atgaaacaaa ggaatagaaa 42780 ttgtattcat attatacatt ttgaaattat atctatatta tattttttgt caaagcaaaa 42840 taaattatac attaaggaaa atatttaaga ttcaaagttg tcattttctt tctgttaatg 42900 agtatctttg atttaataac atttatagtt tggtcacttg aaatctatag tgaccaaaag 42960 caatgtcata tttagtagcc tcatttctgt tactatctga ttattactta agaattctac 43020 ttaattaata gattattaga acaaaaggca ttccaatttt agagattctt ttatggttaa 43080 agcactaggt aacttaaaaa atttggatca aatgttatac agattaatag accttggaat 43140 acaggggcta tgtctttttg gaatcagacc ttgtcctggc cttaattgca ggatgacttc 43200 cttattaaat ctctaaaagc aggaatgctc tggaacaatg aacaattaga atgtggtaat 43260 gtaattttgg gccaaaaaat actttgtaga aatgtgattc tcttacttgg aatagaaaga 43320 attctgactc gaaaaagtgc agttaatgta tgcttttctg ggtaagattt gtgatagatt 43380 ttgattgaga tttaaaacca tgatatataa atttagcttt tttgtcaaag taatttgcca 43440 ccctagaatt tgtgttggta atttttaatg caacttggac aatttctgaa agatgtaact 43500 ttcttttttt tgagacgagt ctcgctttgt tgcccaggct ggagtgcagt gacatgatct 43560 caggtcactg caagctccgc ctcccgggtt cacaccatta tcctgcctca gcctcccgag 43620 tagctgggac taccggcgcc cgccacccca cctggctaat ttttttttta tttttagtag 43680 agacggggtt tcaccgtgtt agccaggatc gtctcgatct ccggacctcg tgatctgccc 43740 gcctcagcct cccaaagtgc tgggattaca ggcgttagcc accgcgccca gcctgaaaga 43800 tgaactttaa aatggggaag gatactagta aagccatttc ttactcatgt atacattttt 43860 ccctccatga aattagagca gccacctttt acatgacttt tacatgcatt tcagattttt 43920 gtactagcaa ttaaaatatc tactggatgt aaatcacatg tgcttaatgc tttgcttcat 43980 aatatctgtt gaagtcaatt aaaatataga gacagatctt taaattgaac atgttttatt 44040 tgggaagcaa gaattaaatt tgaggcatat acacagactg ggtgtccttg gtatctctga 44100 agaacaaaga gaagtttgga ggttatagaa aaaggaaaat gtgacattgt ttttccagaa 44160 agttctttgg cactagtaaa ttttggggag ttggaagctc tgatgggtta gtgactgtgg 44220 tgggtaaaac tagtcttaga gtcacaacag gttgtttcag tatctattag ataaaacagg 44280 ttttaggtta caataggcag tttcagcagc taggcttgca gaaaattaca ttcttagagt 44340 aatgttatgt gccttgagtg cttttttccc cttggccctt gactctgatt tagttgggta 44400 tgacaagaat tatcaattta tataattact ttttacatat tgaagctgaa taggttttct 44460 taaaacttgg aaatgggaaa tactgggtct tgtgaagttt tagtgtgaaa acgataacta 44520 gtctcttatt tcatgctctt tgtaacaagt ctacagtaat acctaatgta tctagatgac 44580 acctcagaac caggagggaa caaaaaagac ctctgagcag tcaaaataat gctataagca 44640 tgtattccag cttactttcg gcatttctgt ggagtgcagg aggccacatt ttgttcatag 44700 atccagtttg acaagcttgg gtactgagtt aaagtgaaaa tggtgtaaat aagtaatcat 44760 attcacatga cagtaggtgg aagtgacagc tgacaatctg aaagagtgga caaaactata 44820 aaaattagaa ctaagaactc ttaaaataga acggtttgaa gtttgttaca gaagggagca 44880 gctttatgct tcagtggact ctgaaggtat tggcagtgta tagtactgct tagtcattga 44940 tttaaattcg gtatatatct cttctattgc tgtcatgtac ttgacattct gctgggtgct 45000 aaggctgtct gcaggctact aatatgcata ataacaatcc tgaaaaagaa ggaaaagtat 45060 actgtgcctt actgaagaag gcaggacagc cgttggtatt tgttagagta aatattagtt 45120 atcttacata aagcatgtta tattccctga tgtcagggcc tgataaatga gcccttacac 45180 tcttgatagt caatctgtgc cactgttgct gtgtttgtat gttacaccat ttcctgtcca 45240 tgtaacagtt aaactgtatc acatatctgt tcctactaaa ctatttgcat ataattttaa 45300 catttgagtg gctgtatata aagctaaaag ttctttataa gatttatagc atcttagaat 45360 gtttaaatta gataacatta gtgtgctttt agtttttgaa tttaattttg ctcttgattt 45420 tgtttgtgtt aatgtagact ttgtctacgt aagcttgagc ccaactttgg agtggtgttt 45480 tcagtgatgg aagtaactgg aaataactca tgaaaccact tagtactttt gatagtttat 45540 tcccatgaag gatcaaattt ttacttgagt cattaatata aaaatttaaa agacatgtca 45600 gattttatta agcatggatt ttaaatatat aaatattaga agacctaaac aaaatcgcta 45660 atgaaagagt aaaacatgtc cctgcctatc atactccctt cactttcact gatttctgct 45720 tttatgaagt actttaataa gctctacaac aaataaacaa gacattgtgc ctcattttac 45780 actctagcag tggttttcca ttccaactaa ctagattggg tttataatat agtcatttaa 45840 acttacttag ttaaaatgtt atacattagc aactgcaatt aaggagctaa gaaattcagc 45900 tcgtatttat ttatatgcat cttatccata gtttctcact tgttatattt gcctactgat 45960 ggcaaattga ttttttctgt tccaaaaatg tagtgttttg agatttttgg agatgcaaaa 46020 cagcatcatt ttcaaattag atcacaaaca atcttacttg ttgcagttga gactagtaat 46080 tgatcagtga ggtgaaaaaa ttaggcaaaa cggtatcatc aaaattttct ttcttttttt 46140 ttttgaaaca gagtattgct cttgtcgccc aggctggagt gcaatggcac gatctcagct 46200 cagctcactg gggcccctac ctacgggatt caagggattc tcctgcctca gcctcctgag 46260 tagctgagat tacaggcgca tgccaccaag cccagctaat ttttgtattt ttagtagaga 46320 cagggttttg ccatgttggc caggctggtc tggaacttca gacctcaagt gattcacctg 46380 cctcagcctc ccaaagtgct gggattacag gcatgaacca ccgtgcccgc cccaaatttt 46440 cttttaactt aaagtgttaa tgtttgtttg ttcccaatat ttttatatat gtcaaggctt 46500 tttcattata tacaggccag ctctttggag ttctgcatag tgtttcttgt ttaaaccaca 46560 cctataatgt accatctaca atttccaatt ctttaagaca gagtgaaaaa ttaagacacc 46620 tgaagcaatc tgagtgcgga gtcctaggca ttatgatttt ccttgacact tttagggttc 46680 ttttatcaca gtttatcaaa cacctttttt tttttaacaa aaaacaaatt tacaaaatct 46740 ttccatgtat tcaacttaga atttaatgaa atagggtttt tttttttttg gtggtcatgt 46800 atcatcaact ttctttacat ttaattaaat taatcaacaa aaaacatata gttgacataa 46860 acaaatttgg gaccaagcac tactgactct tagtaaacat acaagtcaac tgttggtgca 46920 gaagtgcctt gatgctagag agtagcctgc aagctgtaat tatatatggg cattagggaa 46980 tgaagaacag ccttaatact attgatcttt taagtgaagg tcagcttaga aagcttttac 47040 ttgttaaaaa gcttcacagt ttgtccttgt agttaatgca attgaagttg aattaatctt 47100 tcttaatttt ttttttaggg tttctatctt actaaaggat atttcagaaa atctatattc 47160 actgaggagg atgataattg ggtctactaa cattgagact gaactgaggc ccagcaataa 47220 tttaaactta ttatcctttg aagattcaac tactggggga gtacaacaga aacaaattag 47280 agaacatgaa gttttaattc acgttgaaga tgaaacatgg gacccaacac ttgatcattt 47340 agctaaacat gatggagaag atgtacttgg aaataaagtg gaacgaaaag aagatggatt 47400 tgaagatgga gtagaagaca acaaattgaa agagaatatg gaaagagctt gtttgatgtc 47460 gttagatatt acagaacatg aactccaaat tttggaacag cagtctcagg aagaatatct 47520 tagtgatatt gcttataaat ctactgaggt actaaataaa gaggaagcac atttttagtt 47580 attagtaggt tctggcagac tttattcccg taaagagaca gatagtaaat attttaggct 47640 ttgtgggaca tacagtctct gttgcagtaa ctcagttctg ttattgtagt gtgaaagcag 47700 ccacagacaa atgtaaacaa atgtgcctgt ctttcaataa aactttatct acaaatacag 47760 atagtgggcc acatttggct tgcgagctgt agtttgctgt tcctgactta gtatgatatg 47820 cagcattgtg tagtggaaag attttatagt atcaacagac atttgtagga gtttgctatt 47880 ttataatttc gtatgctttt ttcataatag atgtctctgc tttttgtgga ttctcttcat 47940 atctactagt gtttactctt ctgactttga tttttggggg tgtattttat ttctttatac 48000 agaatttttt tcttttttct ttcttttttt gagacaaggt tttgctgtgt caccccagct 48060 ggagtgcagt ggtgggatct tggccccctg cggtcttcaa ctcctgggct taagcgatcc 48120 tgtcacctca gcctccctag tagctgggac cacaggcctg caccactaca ctcagctaat 48180 ttttgtattt tttgtagaga tggggtttcg ctctgttgcc cagactggtc tccaactcct 48240 ggactcaagt gatccacctg ccttggcctc ccaaagtgtt ggaattatag gtgtgagtca 48300 ctgtgcctgg cccagaattt ctttacttgc tcatgtgaga gagtttctaa taaactcctg 48360 atgcttttgc ttgacactat agttttactg tcatctcaga gtcagatttt ttccttaatt 48420 tcttcattaa attgatttct taatttctca tttgttttgc attagtttac aaaattactt 48480 aagatgccta tattctctga aattttatat tttatttcac gataaataag tttaaaaaat 48540 tagatttgac catttaatta gagttatttc cccatcattt ttctaatggc aacaataatt 48600 ttagcatttg agcaattctc tgtattttgg taactattag taatcacttt tatcagtata 48660 aacatgcatt tcattttaaa atggttttca aaatattctc ataccaacca ttcataaaag 48720 atgttcccct tctgggaaat atcagttttt gctaacatct gcatttccct ttgattttct 48780 aggaatttct tattaggtat acactttaag tgatatgttt catataatat tataggatta 48840 tcaggatttc atgatttttt ttttttgaga tggaatctat ctctgtcgcc caagctggag 48900 tgccgtggcg cagtcttggc tcactacaac ctctgcctcc ccggttcaag tgattctcct 48960 acctcagcct cccgagtcac tgggattaca ggtgcccgcc accacacccg gctaattttt 49020 gtatttttag tagagaaagt gctgggatta caggtgtgag ccactgcacc tggccttgga 49080 tttcgtgatt tgactgacat cttttacacc aattattgcc atttttttat tgggtactaa 49140 ttattagtat tgctttcttt attcgttaaa taagaagtaa aagaactttt aaaaaataaa 49200 ataacttttt ttcctagtac aaagcttatt ttcaattttt tttattgctt aaattttgca 49260 ggttaattaa ggctgtactt ctttttccta cttcctgttt aaatatttgg cattttttga 49320 gggttttctt tctatggatt tttgtggggg atcccatctc gttggacact tggttcctgg 49380 agattgccaa attattgaaa agtttcctca tacccaaaca ttggcaatag actgaataaa 49440 taacatctct gacattattt ttcaattata tagagaatgc tttttgtaaa atactgattt 49500 atttaaagat attacaatca tagtagtttt ttgcaatctt ttttaaatca gtggatgtca 49560 aggaacaact attgttcttt gtacggcatt tttcaacatt gtgaagagtt cttatactca 49620 aaaagtttgg gagacacagt gtgacattgt ttaacctgag ttgaacttgt cattttgtat 49680 tcttgtttag agcagggatt ttattttgtc tctttatcta actttgtatt cctaactatt 49740 tctttctttc tctttggttc tttgtttctt tgttcattct tctctctctc ccttttttat 49800 ctatcatata aatatgtaaa tatatattat atatccatta gggaagagga agttgtctaa 49860 agatatctag tatataggag ctttgttctg cagaaaagag gatatgaagt caattatatt 49920 ggaaattaat gcttaatact ttttttaaag catttatctc ccaatgataa tgaaaacgat 49980 acgtcctatg taattgagag tgatgaagat ttagaaatgg agatgcttaa ggtatgttta 50040 caattataaa aatattactt caagttcttt ccaaaggaca tttaattaag taaaatatta 50100 actaattcta aactaggttc taccacaatg aaattgctac taattatgta acattagatt 50160 tcacattttc caattcatgt ttctttcatg tagtctataa ataatgggtt agaggtaatt 50220 tactaatttt aaatgtgctt tccttgttcc ttcttatttt ttattttgaa gacagggtct 50280 cactctatca cccaggctgg agtgcagttg ctccatctcg gctcactgca accttcacct 50340 cctgggctca agtgatcctc ctgcataagc ctcccgagta gctgggatta tgggcgtgca 50400 ccaccatgcc cggctaattt ttatagtttt agtagagaca gggtctcacc atgttgtcct 50460 tgctggtctc gaactcttta cctcaagtaa tccacccgcc ttggcctccc aaagtgctgg 50520 gattacaggt gtgagccacc acacctggcc ttggatttca tgatttgact gacatctttt 50580 acacaaatta ttgccatttt tttattgggt accaattatt agtattgttt tctttattcg 50640 ttaaataaga agtaaaataa ctttttttta aaaaaagaac ttttttccta gtaaaaagct 50700 tattttcaat ttttttattg cttaaatttt gcaggttaat taaggctgtg cttccttttc 50760 ctactttctg tttaaatgtt tggcattttt tgagggtttt ctttctatgg atttttgtgg 50820 gggatcccat cttgttggac acttggttcc tggagattgc caaattattg aaaagtttcc 50880 tcatacccaa acattggcag tagactgaat aaataacatc tctgacacta tttttcaatt 50940 atatagagaa tgctatttgt aaaatactga tttatttaaa gatattacag tcagtagttt 51000 tttgcaatct ttttaaaatc agtggatgtc aaaaacagct attgttcttt gtacagcatt 51060 tttcaacatt gtgaagagtt cttatactca aaaagtttgg gagacacagt ttgatattgt 51120 ttaacctgag ttgaacttgt cattttgtat tcttgtttag agcagggatt ttattttgtc 51180 tctttatcta actttgtatt cctatttctt tctttctctt tggttctttg tttctttgtt 51240 cattcttctc tctctccctt ttttatctat catataaata tgtaaatata tattatatat 51300 ccattaggga agaggaagct gtctaaagat atctagtata taggagcttt gttctgcaga 51360 aaagaggata tgaagtcaat tatattggaa attaatgctt aatacttttt tttaaagcat 51420 ttatctccca atgataatga aaacgatacg tcctatgtaa ttgagagtga tgaagattta 51480 gaaatggaga tgcttaaggt atgtttacaa ttataaaaac attacttcaa gttctttcca 51540 aaggacattt aattaagtaa aatattaact aattctaaac caggttccac cacaatgaaa 51600 ttgctactaa ttatgtaaca ttagatttca cattttccaa ttcatgtttc ttttatgtag 51660 tctatgaata atgggttaga ggtaatatac taattttaat tgtgctttct ttgttccttc 51720 tttttttttt ttttattttg agacagggtc tcactctgtc acccaggctg gggtgtagtg 51780 gtgccatctt ggctcactgc aaccttcacc tccagggctg aagtgattct cctgcatgag 51840 cctcctgagt agctgggatt acaggcgtgt gccaccatac ccggcttatt tttgtatttt 51900 ttgtagagat ggggtttcac catgttgccc aggatggtct taaactcctg ggctcaagtg 51960 atctactggc ctcagcctcc cagcgtgctg gggattgcag gtgtgagccg ccgcatccag 52020 ccctgtgttc cttcttgtgt tactttcttg taattttttc ctggaatatg ggtagtgatt 52080 tggctctcca gtattgaaat tgagtttcct ttcttccaat tcatgtgtat ccatttttat 52140 ttggaagttt tgtttttata cattcaataa tcatctttac tttctttggt attatttact 52200 atggatattt tatattatat aattttcaaa tggattaaat ggttcagttt tactcttatt 52260 attgagattg aaaatactag tttataattt atatattttc tattccttta cctctaattt 52320 ctttgtcagg tgttactaac caaagatgta taataagaaa agccaatgta gctaaattaa 52380 gtaaaaaatg aagaaaaaca cagaagttcc ccattatgca tttttttatt cctaatcttt 52440 aggttgatga gattttttta tttttatgaa atgagattaa tttattgact tttttagttt 52500 tgaggccaag taatgagtag tgagtaagaa tgtatattct agggccaggc atggtggctc 52560 actcatgtaa tctcagcact ttgggaggcc gaggcaggag gatcacttca ttccaggagt 52620 ttgagaccaa cctgggcaac atggcaaaac cctctctctc cagaaaaata caagaattgg 52680 ctgggtgtgg tggcatgtgc ctttagtccc agctacttgg gaggctgagg tgggaggatc 52740 acctggggag cctggggagg ttgaggctgc agttagccat gaccatgcca ctgcactcta 52800 gcctgggtga cagagtgaga ccctgtctca attaaaaaat taaaaaaaaa aaagtagatt 52860 gtgaattcag atgtaggttt gtatcccagc ttttccagtt agtatctgtg tgactttggg 52920 gaagtttctt agcatctttg atactcggtt aacagttgta attattattt aaggtattgc 52980 ttgagaagag cttagtatag agcctgacat ttagtaagtg tttaatacat attagctaac 53040 agtaaaacta gaacataaat actgaattgt attttgttat taattatcca tttctctgag 53100 aagtactgtt ccaatagtac atttatagga aacttgtgga cgtctacaaa cgtatacatt 53160 aaatctctta gaaggcaacc tggatgccca tattagagaa ctctatttta aacatgcatt 53220 ctaagtatgt ttgtggactt gaataaaata aaacaaacag aaacacttct ttcttctgcc 53280 ttcaggcttg aaatgaacat actttttttt aaaaaaaaac cttcaaaatg aaaatattaa 53340 ataaaagatt taataaaaag agaaagtaaa aactgtagtt taataaagtc ttcctgtctc 53400 ttcatagtta aaaaatgtta tagatgaaac aattttgaaa tattcttgaa atagataatc 53460 tttatttagg ggagaatgtc agatactgtc aagccaaaat aaaaacaaat aactttattt 53520 catgtttgta aaattccttt tctaaaatga tttgaatctt ttgttgtttt gacaattcca 53580 aaacacattt attgtttgct catagtttca gccttattca gaaagaatgc gactgacaca 53640 tgatatagag aaacttgttc caaaaataac attaaaatcc acgtttacta cttgagaatc 53700 gaaaatattg aggtgcaata aagaataaaa tgttttaaat tatccaaatt taaaatttat 53760 gatagctttc cccaggggca gtttattata tgctattaat gagccttgtt tatgctggaa 53820 atgttccatc tttggccttg cgccttagaa accattcatg agcacatatt taaaccggag 53880 cacacatgtt cttttgtagt atggcttgca catctgccag ctttcgacaa aattgtaggc 53940 cctgttaata atagtccttt tgtgtttggt gaaaaagata cgacactgtc agtggttttg 54000 cttttaagat ttcttttaaa ctttcagtct ttagaaaacc tcaatagtgg cacggtagaa 54060 ccaactcatt ctaaatgctt aaaaatggaa agaaatctgg gtcttcctac taaagaagaa 54120 gaagaagatg atgaaaatga agctaatgaa ggggaagaag atgatgataa gggtaagcac 54180 tgaagtatgt ttgaaatgac tcacctgtga tacctaccac tgactttaac ttaggatcca 54240 gttttggatg gtttggaggt cagggacttt gtggcatata gttaattatt ggatccttat 54300 aagcttttgt ctccttagtg cttttgtctc cataaagcac aatcttacta cttagaaaaa 54360 tagagtaata gcattatgat gataaaaata tctttccctt tgtttttttg tatttctcca 54420 aatcattata gctctcattt agaattatta aagctgagaa ctctaacaat gaacttttat 54480 tgtttagtgg ttaattatct tgattctttg ttttgccctt tcttggccac tcaggaatct 54540 ttcaagctca ctgtggacag ggaaagtgac ttgggtagag ctaacataac ttcattgtgc 54600 tgtgcagtta gaattttgac caaagatgtg ggtaactaac ttttcctaac taaatgacat 54660 ttaggtaact aaactaaacg agattttcgt aactaaattt tggtgtaact acatttagct 54720 ttaggtaact aaaacgaaga ttttatttta tctgtggatt tttttagtgc gggactaatg 54780 taatttctga ttaccattaa ttgaaggttg gttatattat aacatttgga ttggtatatt 54840 gcttgccatg gtttgttcta aatgttagcc tttagaagta ttcctgattc taaaacatca 54900 gtttttttta atagtcctgg caaagtgtga atcacaacaa aattctaata cttaaaagta 54960 atccaagtgt cacagatggt acccagaaga ccagtttgta ttggaattaa aaaatagaaa 55020 acattaaccc atggtagctg tcactgtatt ctttcaaaga agccaatgaa ataaactgtt 55080 ttctccctct atgtggtgtt tttctacttg aacataaatg cacattttat tttatttcca 55140 gactttttgt ggccagcacc caatgaagag caagttactt gcctcaagat gtactttggc 55200 cattccagtt ttaaaccgtg agtataatct catttaatca aatcacatat ttagtattct 55260 ctttaaaaca agggaaaagg caaataacct gtctgcttaa cagcaacagc acaacttcac 55320 tatagttata catgccacac tgtattttct gtgtgactac aaaattattt caaagtgata 55380 tttatataaa attcatttct gcaaattgtt tttataagtg aggaaaaatg gttttccttt 55440 aactgagcag ttctgagtag aaactagttt aaagatactt ataaataaat gttaatttaa 55500 tactgacttg tttttcatta aacgagtgtc tatgtgcctg ttttgtgtat attacccaga 55560 acatgcagat gtactagaag ttcttaatac aacaatttga ggaatagtga taatcttatc 55620 tattttaatg tactcaaaat ttgtttacat ctaacaggca catttttgtg aggattaaat 55680 gagatgaata agaatgagat gaacaagtaa atgtgaataa aactaataag cctgtgaaaa 55740 tctagactgg atttttccta ttctgagaat ttaaaatata atccactgaa gtatttcttt 55800 ccttttttct tttgatctta aacatttttt atttatgtct tacatacaga aaagtgcaca 55860 tgttgtagag atcaatgaat tgtcataaac tgggcaccct gtggccagca cttagttaag 55920 aataggtcag taacagcatg ccagaagacc acctctccaa ttgatttttc ccatgatatt 55980 ttattaagaa aattttctaa gatgtagtaa agttgaaaga acttttttct gtgcatgtct 56040 gtattcccac cacctaaatt caactatcat tactatactt gctttatcac atatccatcc 56100 attcatatgt ctctatccat ccattcattc attccagttt taaaatgcat ctcagggtca 56160 atcgaggaca ccattacact tccacctaag tatttcagca tgtaaattat taacgagtta 56220 aatatttact taacagtttt ttctttggtg taaaatttgc acgtaaggaa atataaaact 56280 ttaagtgtac atttgcaaat tttaaatata catgtgcata cccatgtaac ccaaattctt 56340 atcaagagat attattatca tcaccacaca gagttccctt atttcccttt tcagtcagtc 56400 cttgtccctg agcatttctc ttattatttt aaagtattga ttcttttgga tatctagtat 56460 gaagcttaga atctgttttt tactttagat gtatgtagtg aaatttaata tatataccaa 56520 atggtagttg ttagttagct tgaatgggac attggtcaaa tggcattgtt tgttttaaag 56580 ttccaggttt gtgcatttat gtatgaagtt tgaaaataaa ttctatgaga ggaaatgaaa 56640 aattgaatgg attttaattt gtaccttggg tttcttatta ataaaacaaa atagcttttt 56700 gcttttcacc ttcaagagtt cagtggaaag tgattcattc agtattagaa gaaagaagag 56760 ataatgttgc tgtcatggca actggtaagt tgtacttaag caaaacctaa tcctttaaaa 56820 aaataaaaca taaagagttt gaaatgctta atctttcatt aaactctcaa aatacaaatg 56880 caactacaaa tgatgtaaac tatagaagag agtgaacaaa gaacagatgc tcagatttat 56940 gtatcaatta gcttttagga agatagcata ctagtattga ccattcatct gtataagtac 57000 attgtaaaaa gaaatgaaag catcaaaggt ttatttttat ttctatattt ttttcatttt 57060 atttttatat ttttttcatt tcaaggatat ggaaagagtt tgtgcttcca gtatccacct 57120 gtttatgtag gcaagattgg ccttgttatc tctcccctta tttctctgat ggaagaccaa 57180 gtgctacagc ttaagtaagt catgttatca ttgccacaat atcaccctct ttttttcttc 57240 tgtgggtgaa acatctgatc catcatgcat gttaaaatct agttcacaat aacacatttc 57300 tgcaggtatt gctttatctt tattggtaat aaatgaccct ttagtggaag agcttacctt 57360 ctttcttgtg ttctctgtaa ttcaaagcta ccaggtggcc ctgataaaat ttttttaaaa 57420 aacattatta ctttatgctg gtttacattg aatatctcaa aattcttttc tctttttgtt 57480 acccttgctt tttagcttga taagaagtgt atacatggaa gtatattttt tatctatgaa 57540 acacttttca gcttcttcaa cctgagcttg caatctgttt taaattgata cataatatct 57600 ttacatattc atggggtact gtagtatttt gatacactca tatcaaatac acttgatcaa 57660 atcagggcat ttgttcatca acttgaacat ttatcatttc tttgtgctgg gaacatttct 57720 aatcttttct ttgagttatt ttgaaataca cagtgttgtt gttaactata gttaccctac 57780 tgttggttaa tgagtacaaa catacagtta gaaggaatag gttctagcaa cctattcctt 57840 taccccctgt catcccctgc tgccctgagc ttgcagtctc tttcaaagac ccaccttaaa 57900 aacttgcatt ctgataaggc ccttgaagga atttgcttat caagttagta agtgacaaaa 57960 aagaaaattg caaagaacag gaatataaat tattatattt ctttattctt tctcacttaa 58020 gagtgaaatt gatatgtgta atgtgtacat ggtgccagaa tatttgtttt tcttcttata 58080 gaatgtccaa catcccagct tgcttccttg gatcagcaca gtcagaaaat gttctaacag 58140 atattaaatt gtgagtaatt tttttccctc aacttttatt ttggatttat gggggtgcat 58200 atgcaagttt gttacgtggg tgaattacat gttgctgagg aagttgtgag taatttatgt 58260 catttctaat catgtggtca gatgtctgtg gtatatgaga gaattttgta tacaaacaaa 58320 ttttactaaa tgcatgaaaa aaaaagtcca tgattttaaa atgcactttc ttttgtacct 58380 ttgcaggact gttacttttt aaatccttca aacttgaaga aatctgttat tctcggttct 58440 tgggctataa gattagcatt gtactcatag aattataaaa attttggttt tggaagagaa 58500 gttggagaat ataaagattt gtctcatttt atagatgaga aaactgaggc tcagagacaa 58560 gtaatttgcc caaaatcaca caatgactgg ctgagcaggg actggattct aggtctcttg 58620 cccaaccaat tctatcatga tgtaattcct aaggagaatg tcatctcaga tacacataca 58680 cacacccatt ttgtgtgtgt gtgtgtgtgt gtatatgtac acacacacac aaacatatgt 58740 acacttatat atacatacac acacatatat taatatatat gcatatatat gcatgttcta 58800 attcagaaca ttttcatcac tcccaaaaga acacccctgc ccattaagca gttgctttct 58860 ttacgtatat attagtatat acatacacac gagatacaca tatatttact gagttttgat 58920 aaatgcatac aaagatgtaa accaaacctc taacaagata cagaatatca ctgacactct 58980 agaaagtttc ttcatgtccc tccccagtct gtccttccat cctccatcct aggcaagcca 59040 ctgctccgat tttctctacc atagtttggt agaatgccat ataaatgcag tcacacaata 59100 ttaactcttt tgtgtaagac ttctttcatt tgctgtaatg tttctgagat tctttcatgc 59160 tgttgcatgt atcagtagtt ttttgttttg ttttgttttg tttttgtttt ttcagagtca 59220 gggtctcctt ctgtcaccca ggctagagta cagtggcgca atcatagctt actgcagcct 59280 ctaactactg ggctcaagct atcctcctgc ctctcaagta ggctaggctg caggtatgtt 59340 ccaccatgcc tggctaatta ttaaattttt tgtagagaca ggatcttgct tggttgccca 59400 ggctggtctt gaactcctgg cgtcaggatt gtttccagtt ttggattatt acaaataaag 59460 ctgagacaca tataagtctt tgtatggaca tatggtttca ttttattgat acatgtcaag 59520 gagtgggatg actggatcgt gtggtggata tatgtttaac tttctttttt ctgagataaa 59580 attagaaggc gatcctcctg ccttggcttt ccaaagtgcc gggattacag gcgtgaacca 59640 ccgcacctga tgcagttgtt gttgttgttg ttgttttaat atctgattat tattttattg 59700 tatttcattg aatatagcac agtttgtttt tacattttct tattgataga cacctaggct 59760 atttttctgg ttttggactg ttactaataa agctgctata cacatcctta taaaaatctt 59820 ttttgtgaac atgttttctt tttttctaag cattttaaat cacctttatt gaggtgtaat 59880 tgacttacaa taaattttat atgctgagaa tgtataattt gataagtttt gacacaggta 59940 tgcactcatg aaaccatcat cacaatccag ataatgaaca tattcatcac ccacaaagtt 60000 tacctttttg ttttaacccc agtcaccggg taactgctga gctccttcct gttactgtag 60060 actagtttgc attttctaaa cttatataca tggagtcatt catattttat gtgctctttt 60120 ttgtctgatt taaataatgc agtataatta ttttgagatt cattcatgtt attacagtga 60180 ttaatagttc attcctctta ttgttaagtg gattacattt tatggatatc caacaagttg 60240 tttatccatt cacctgatag acatttggat cgtttccagt tttgggttat tacaaataaa 60300 actgctatga acattcgtat gtaagtcttt gtatggacat atgttttcat tttattatat 60360 atgacggagc ggaatgactg gaacatgtga tgcatatatg tttaactttc ttttttctaa 60420 ttgagataaa attcacagaa cataactttt accattttaa tcattactaa agtccagtgg 60480 gttttggtat agtaataata tataaccatc ataattaatt ccagaacatt ttcctaactc 60540 ccaaaagaaa ttccataccc attaaggagt cattccctat tttccctttt cttttctttc 60600 tttttttttt tttttgagtc agggtctccc tctgtctccc gggctggagt gcacttgcat 60660 gatcttggtt cactgcatcc ttgatttcct gggctcaatt gatcctccca cctcagtctc 60720 ctgagtagct gggactgtag gcatatgtta ccatacctgg ctaatttgtt ttattttgag 60780 tggagatgag attttgctat gttgcccagg ttgctctcaa actcctgggc tcaagtaatt 60840 gtcccacctc agccttccaa aatgctggga ttacaggcgt gagccactct gcccggccta 60900 ttatctctgt tctgcccact tccaaccact aatctacttt ctgtctctat gatttgccta 60960 ttctggatgt ttctataaat taacttatac attatatggc cttttgtgtc tggcatcttc 61020 cacttagcat agtgatatca gtacttcatt cggtcttttt ttatgactga ataatattcc 61080 atagtatggg catacacatt ttaaaaattc attcatcagt gatggacatt tgggttgttt 61140 cctttttggc tgttatgaat aatgatgctg tgaacatttg tgtaccaatt tttttatgaa 61200 catacatttt caacgctttt gcatatatgc ctaagagtgg aattgctggg ctatatgcta 61260 attttttaag aaactatgaa gcttttgaga gtgattgtat catgggatat tcccaccagc 61320 agtgtatgag aggtccagtt cctccccatc cttgctatca cttagtctgg ctgatcttta 61380 acttaagcca ttctaatagt atctcattgt atttttagtt tgcttttccc taatgactaa 61440 ttatattgag catttttcat acacttattg gccatctgta tatcttcttt gagggagtat 61500 ctgttcaaat cttttgccta ttttttctta gtgagttttg atagtcattt ctatattctg 61560 aatataaatt atttatttga tatatgcttt gcaaacattt tctcctagtt tatggctttt 61620 catactttcc acacagttct tttgaagagc agcagttttt cattttgata aagtccagtt 61680 tgtcgattcg ttcttttagg gattttgctt ttagtgtttt gacccaaggt cacaaagatt 61740 tgcttttatg ttttctccta aaagttttat agttttaagt tttacattta gatttacgat 61800 tcatttttag taaatgttgt ctattgtatg aggtattgat tacagtttat gtatttttca 61860 catattgttc cagctccatt ttttaaaaag actatgcttt tacactgaat tgactttgta 61920 cctttgtcaa aaataaattg actacatata tgtgggtcta ttgctgcact ctctattctg 61980 tgttctgtgg atctatttgt ctgtcttgat tggtgtcttg attactgtag ctttataata 62040 aacctggaaa tcaggtagcg caaggcctct tgctttgctc ttttctttca aagttgttct 62100 ggctattcta tgtcctttgt atttctgtga gcatgtcagc atcacctttt caacccatat 62160 gcctgctggg attttgaatg agtttacctt gaatctagat atcgaaacaa ttagctgtct 62220 tgatagttat tgtcaccgtt ttataccgaa gaaactaggc atactaaagt aacttggcta 62280 acatcactta ccttgtaaga agtagaactg ggctgtttga catcagagct tattctttat 62340 accatttcct atgttaatta gaatacaata ttaatttcat aaaggtaaag gcatatctgt 62400 tttgttccta tttgattcct tgtgaaagca caatgcctag cgcacaatag acacttaaac 62460 ttatctgttg aatggacagg tgaatgcttt taaagtcttt ccatatagaa aattaagttt 62520 cattacattt gacttgatct aggttttcat ttcatagaat ggagagcaga ctctgtaaat 62580 attttgcccc agacctagct ttattacaaa cattgtctta attaggattc tgtctaccca 62640 gaatagaaat taactcaagc tagcatgagt gtatattgaa atttatatta aggataaagg 62700 aatgtctcat agatcccact caaaagaaat tagccagccc ttaggaagag actggaattg 62760 ggtttggaaa atacaatagg tctttctttt tatctgtagt ctttagtgag tcttcctcat 62820 ttttctctct gaagagataa gcattctctg catatatata gcattctttt agattttcgt 62880 gacataaagt attatttaaa ctttcataag gtatcttgat tttaagttgt aattccttga 62940 gatgattgtt ttctttattg ttaatatgtt tcccttcctg tttttttttt tttctttttt 63000 cttttgtttg tttttacaga ggtaaatacc ggattgtata cgtaactcca gaatactgtt 63060 caggtaacat gggcctgctc cagcaacttg aggctgatat tggtaagtga taaagaaaga 63120 tctctgtaaa tacttactga gttaatattt aaagttaaac ctatggatgg acactggatt 63180 tcacttctgt taaagtttat ttcaaacatt acttcctcca ggaaatctct gactctctaa 63240 cttgctgttt cacctatctt atcccatgat actctataat tccttttgct atagaaatta 63300 ggctctgtta tcataattac ctgtttatat atctgttttc ttctgctagg ctataaactt 63360 ttcaagggaa aaatatcact ttttaaaatt tatgtttccc cagtgcagtg cttggcatat 63420 aggcacttaa acatattgtt gaatgaatgt tgaatcctag gttctgtgaa attttaattt 63480 acttgttttt catgttctgt atctaaatta agtcagtgta gtggttttgt accctctttg 63540 ttcataagaa tcacttttca aactttaaaa aaaatgtagg taaccaacac ccaactctga 63600 aaattctgat ttaacaggcc tgggttggca cctggcattg gtggtttctc acaggtgatt 63660 ctgatatata gcccgggttg gaaaccacag tacctttgat tagttgccac tagtgagtat 63720 gatttattac aaaaaccaaa aacttagata agtcacagtt tatttcctag aacgtgtaaa 63780 tatagaatta gtcaaaagct gatagcactt tttttgtact taaaaatatt ttaagcctca 63840 gtatagtgag acctcatctc tacaaataat tttttaaaaa attggccgag cctggtggtg 63900 catgcccata gtccaagcta cttgggaggc tgaggtagga ggattgtttg agcctgggag 63960 atgaaggctg cggtgagcca agatcatgct actgcactcc atcctgggca acagagcgag 64020 accatgcctc aaaaaaaatt tttttttctt cttggtggtt aggcttaact atccaagaat 64080 tgcaatcatg gcttctattg caaatgcccc tatttcccac cttcagttgg cctaaccaaa 64140 tttaattttt caatatcata tgatcttttt gtataattat gtattcaaat aattccagat 64200 aggttaggtt ttcgaattgc aacgtctcat ttaatggtta ctttcatata actgtaggaa 64260 agcatttgat aatttttcca acaatgtaat gaaaacaaac ttgtatcttt tttattatgt 64320 gttaaaacca acaaaagaat gagggcagca attaacattt cattaaatat attagcaatg 64380 agtacattta tgagctctta aactccctta ttgacatact gtattttttg cctttaatgg 64440 acaatgaatt tgatatgttt cctaataggt tgtatgaagt tattgtgaat atttcacttt 64500 ggattaagaa taactaccct atatataaat ttcatggttg tattgcaaaa gctggggtct 64560 atgtccatag tggtttgggt acgtttttac tatttgcttt gtttctgtga tagtgttaaa 64620 tgaataataa gcttaagtat ttaagcaaat acttaatact tctgacaagt agttagaact 64680 ctctattttt gtttttttgt aatggatgag ttatggacac tgcaattatt agagcagcgt 64740 actttgctta tgatggatga aaatgttctc tggttgactc agtgttgaat aaaaagggat 64800 acatgaaata aaaattattt ttgaaatatt ttcctttgcc ttttgttgcg ggaaattgta 64860 caatgcttgc aaaaatgaat atacgcagga tattatttgt acagcagtct gacatttagc 64920 taatcagatt cctcattttt aggtaaatgt taaattactt aagtagtctg gatttttaac 64980 agaaacagca aacatagttt tatagggagg ctccttacca accagacttt taacttaagt 65040 gaatgttggc aaaagcttgt ctaaactgat ttccagggat aaggtttagc tccattaaaa 65100 gctagtttgt caaacctgta actaaagctt tttaaaaaat gaaagtttta aaagagacca 65160 tcattctgtt ttaacctatt taatttaaaa tctgggctga agtaggagta ttgcttgaac 65220 ccaggagttc gagaccagcc tgggcaacac agtgagaccc catctctgaa aaaaaaaaat 65280 gagctgagca tggtacctgt tacagtgcta gttatgaaag aaagaaagag agagagagag 65340 aaggaaggaa gggagaaagg aaggaagggg ctgggagtgg tggctcacac ctgtaatccc 65400 agcactttgg gaggccgagg cgggtggatc atgaggtcag gagatcgaga ccatcctggc 65460 gaacatggtg aaaccctgtc tctactaaaa atacaaaaag aaaaaattag ccgggcatgg 65520 tggtgggtgc ctgtagtccc agctactggg gagggtaagg caggagaatg gcatgaaccc 65580 gggaggcaga gcttgcagtg agccgagatt gcgccactgc actttagcct aagaaaagga 65640 aggaaggaag gaaggaagga aggaaggaaa aatcagtcac tcactcaggt ttagtttcaa 65700 aagccaaaac agtgataata ttgaattttt tccagccact cagtagtacc cagagaattt 65760 tgatacaaat aactgacttt gaccccatgt ttagtaggtt ttttttttgt ttgtttgttt 65820 gttttttttt tttgtctttc ttctccacac tctcttagga ctgttgtagc ttgtaatgtt 65880 agtgaattgt aattgtttat ttgcatgtct gtctcctctt ttagaattgt gaactcctca 65940 ggtcatggat tgtattttat tagtcttttt attcctagaa aagtgtttgg ataataatag 66000 atatttatta accataatag gagtagtagc atttttgtgt gtgtgtgcca ggccctattt 66060 tagcatttta tgtgaatgat ataatttaat ttttagagca tctagaaaat gttaggtacc 66120 attattatcc acattttact tgtgagagga ctgagacttg gaaagcttaa gtaacttgct 66180 taaggtaata cacatggcag atggtggagc caggttctgc atctgggcag tctgacttta 66240 gagcttttta atcatcctcc tcctagtgtc cgaacattat taatgctcag agaagtatca 66300 aagaatgatg atactcattg agggaaaaaa ttattcttaa gtatcaattt gttaattgag 66360 gacaaaagca ctactgttac tactgtgaaa aatctgaaaa cattgtcacg gatgatttta 66420 caataacatc cttttctgac atgcattaca acacactatt gattccgttt caatgtttgt 66480 gtctggtatg ggggcggagt agagaggcta ctacaggaag aaagaacaaa taacatttct 66540 tcttactact ttgtgcatca tgtgatttag ctcctcccat accattttac attagaaaat 66600 gtggctgtcc tcctgtgctc tagtactggc atttcagagg actctttgca atatgatatg 66660 tgatcaatca tggatggcga tgcagttaat ttcagtagaa atttgctgac tctttttatc 66720 tcttttaata gctaatgcat gagataaaat tgaaggtatt accaaggaga aatgcaggtg 66780 gatagttttg gaggcaaagt cacagtaagc aattcatctc tccaaggaat agtgatgaaa 66840 gctgagatcc aataaatgtc ttgtttggat taatacataa atatttcctt ttaaaattct 66900 taaggctttt attcatatat ctcccctctc cctatttcca ataatgattt ttggtgttaa 66960 tatgatgata tttatgcttc tgtttttata ggaaccaaat actttgattt ggttatttat 67020 tctcctttgg agatgtagat gagtttattt tttcctttcg agctttatct tttcctttat 67080 gtgtttttct ttttttacag gtatcacgct cattgctgtg gatgaggctc actgtatttc 67140 tgagtggggg catgatttta gggattcatt caggaagttg ggctccctaa agacagcact 67200 gccaatggta agctttgcca agtctgatgt cccgaaatta cattcttaat aaggagagca 67260 ttcaggattg gggagtggta aagaagctga agacttcact ataaaagagc aaatggataa 67320 tgtaaaaaga gaactatttt tttaaaaatg ctaaagttgg tatataatct attgaggaat 67380 ataatagaac aaggcttgac aaaccttttc tgaaaggacc agataataaa tatttcaagc 67440 tttataggcc acatgtagtc tgtatcacat attcctctct ctgttttttc ttttagtaac 67500 cctttaaaaa tataaagagt tacatttttc actggtgggc cataacaaaa caggctgtgg 67560 gccatatttg tccgaatgtc ttctcagtga tctttcatcc gtatgtcctt ttactctagg 67620 atgctgtgaa atcctggtta ccccttcttg tatcacattg aaaacctaaa gtttgaacta 67680 ttctatagaa attttattaa agcttttggt attagaattt ccctttcttc cctaattata 67740 aaaaatagca aattttggcc gggcatggtg gctcacgcct gtagtcccag cactttggga 67800 ggccgaggtg ggtggatcac ctgaggtcag gagttcgaga ccagcctggt caacatggtg 67860 aaaccctgtc tctactaaaa atacaacaat tagctgggcg tggtggcagg tgcctgtaat 67920 cccagctact tgggaggctg aggcagggga attgcttgaa ctcgggaggt ggaggttgca 67980 gtgagccgag attgtgccat tccactccag cctgggcaac aagagcgaaa ctctgtctca 68040 aaaaaaaaaa aaaaaaaaaa aaaagtgaat ttttacatga atattctaca tgattggcat 68100 atttacatga atggtttaaa aacccacaat aatagcactg ttttattttt tattttgaaa 68160 attgtagatt cacaagaagt tgtaaaaaaa aaaataccta tatagaggtc ctatgtacct 68220 ttcatccagt ttcctgaaca gtaacatctt gtgtgactat agtacaatat caaaactagg 68280 aatatgacat ttgtacagta tctagagttt attcctattt ctctagtttt gtaagtactc 68340 ttttgtatgg catgtgtatt gttctataca gtttaatctc atgtacattt gtgtaactac 68400 cactgcagtc aggatgccaa atgttccctt accacaaagc tccctggagc tgttcttccc 68460 acccctggcc ctagccactg gcaaccacaa atctggtctc tatctctaaa atattatttc 68520 aagaatgtta tatacatgga atcatgcaat ttgtcacctt ttggaattag tttttttcac 68580 tcaacataac taccttgaga tctatccaag ttgtttgtgg tcatgtgttg cctaacaaca 68640 gggatatgtt ctgagaaatg tgttcttagg acattttgtg gttgtctgaa catggactta 68700 cacaaaccta catgataaag cttactgcac acctaggcta tatgatagag cctattgctc 68760 ctaggctgta aacctgtaca gatgttactg taatgaatat tgcaggcaat tgtaatacaa 68820 tggtaagtat ttgtgtatct aaacttatct aatgtagaaa agacacagta aaaatacagt 68880 ataaaagata aaagatggta tacctgtata gggtgcttcc tgtgaatgga gcttgtagga 68940 ctggaagttg ctctgagtga gtgagggagt ggcgagtgaa tgtaaaggcc taggacatta 69000 ctgtacacta ctgtagactt tatacatatt gtacacttag gcgacactaa atttttaaaa 69060 ttttctttaa aaattttctt tcttcaataa taaattaatc tcagtttact gtaactttaa 69120 ttcataaacc taaaacattt tttgactttg gactcttgta ataattctta gattaaaaca 69180 tgaacacatt gtacagctgt acaaaaattt tttcttcctt gattaatgca ttccataagg 69240 ctttatttta aaattttatt atttttattt ttaaaacttt tttgttaaaa actaaaatac 69300 acacatatca gactagacct acacagggtc aggatcatca atgttgctgt cttccacctc 69360 cacgtcttat cccactggaa gttctttagg ggcagtaaca ctcatggagc tgtcatctgt 69420 gataacaatg ccttctccta gatacctcct gaaggacctg cctgaggctg tttttcagtt 69480 aactttaaaa aatgaatacg taggaggagt atactctaaa ataatggaaa agggtatagg 69540 taaatacgta aaccagtaac atacttgttt attattcatc aagttatata ctgtatataa 69600 ttgtatgtgc tatacttttt aatgcctggt agtgcagtag gtttattgac agcagcatca 69660 ccacaaacgt gagcagtgcc ttgtgctaag acattatgct ggctatgaca tcacttggtg 69720 ataggaattt ttcagctcca ttataatctt atgggaccac tgttccacat gtgctctgtc 69780 attgacagaa atgccgttaa gtaccacatg actatttttc ggtggtctgt tcctttttat 69840 tattacagag tattccacag tatggttgta ccacagttta actgatcacc tgttgaagaa 69900 cttttgggtt gttttccagt ttttgactat tatgaataaa gatgctatga acatttgttc 69960 atatctcaaa ggttctttat ttttttttat ttatttttct ttttttgaga cagtctggtt 70020 ctgtcaccct ggctggaatg cagtggcgcg atctcggctc gctgcaagct ccgcctcctg 70080 ggttcacgcc attctcctgc ctcagcctcc cgagtagctg agactacagg cgcccgccac 70140 tgtgcccggc taattttttg tatttttagt agaggcagcg tttcaccgtg ttagccagga 70200 tggtctcgat ctcctgacct cgtgatccac ctgcctcggc ctcccaaagt gctgggatta 70260 caggcgtgag ccactgcgcc cggccttcag agattcttta atgggtgaat ggttaaacaa 70320 cctgaaaata taaaagtttt catttctctg ggataaatgt ccaggagtgt atttttagtt 70380 tttaaggaat tgtcacaaac ctgttttcca aagtggctgt agcattctac attcctgtca 70440 gcagtgtgtg aatgatctag ttatccttgc caccgtttgt tgttgcaact gttttttatt 70500 ttagccattt cgataggtgt cgagtggtat ctcactttta atttgcattt ctctcatggc 70560 taatgatggt gaacgtcttt tcatatacta atttgcctct ggtgaaattt cttacataat 70620 tggagtgctt gtttttttct gttgagtttt aagagtttaa aaaatacatt gtagatatga 70680 gtccttggtc agatacgtgg tttcaaatat ttctttcact ttgtagcttg ccttttcatt 70740 ctttttaccg tgtctttcac agagtaaata tttaacattt tagtgaaatc cagtttatca 70800 ttttttcttt tatggattgt gctcttcacc tagccctaga tcctgaagat tttctcctgt 70860 ggttctttcc taaaattgtt acagttttat gttttaagtc tgtgatccat tttgagttaa 70920 attttgtata aggtgtgagg tttaagtcaa ggttcattgt tttcccaata gattaaattg 70980 cagcagatcc tttgttgaat aggctgtcct tcccctgtta aattgcgttt gcccctttgt 71040 tgaaagtcat gtgggtgtat ttgtgtgggt ctatttctgg gttctctagc ctgttatatt 71100 aattttgaac gaataaagtt ggcttatgtt taagttttct tggtagtagc gaggcaatgg 71160 tgccttctga gcccaggatt tcacaatttt gtgagtaaac tgtgttagaa attgtttgtt 71220 attcttttgg taggttgtct agttcaattt cattgctcat taatcttgct tatagatagc 71280 aaattgagag gcatctcaaa aatagtatct tttgttagct tatctcacag agtttggttg 71340 gagcagatat taaaacaaca aaccaaaaat aaattaaata tactagttag caagtttata 71400 ttgagggaaa atcaaaccat gtgaattgag ctccaatgat gtggctggcc ttgggtcaga 71460 ttttagtatc atggttcaac aaggtagcta ttaaaatctt catacttttt cttgaaataa 71520 ttctttagta gtcacatagg acagcacaca ctcatggatt tcttctttcc ttactgtctc 71580 tttattctca gcctcctgtt ccttctcatc tccctgacct tttaatgttg gccttccaga 71640 aactttagtc tttggaccta cctttgcact cattttcttg gtcatttcac ccaacataca 71700 gttttatgtt attttatttt ttttattttt gagatggagt ttcactcttg ttgcccaggc 71760 tggagtgcaa tggcgtgaac tcaccttact gcaacctctg cctcccgggt tcaagtgatt 71820 cttctgctca gcctccccag tagttaggat tataggtacg tgccaccatg cctagctaat 71880 tttgtatttt tagtagagat ggggtttcac catattggcc aggctggtct cgaactcctg 71940 acctcaggtg atccacctgc cttggcttgc caaagtgctg agattacaga tgtgagccac 72000 cacgtccagc ctacagtttt aaatatcaag tctatactga ggactcccaa atttttatct 72060 ccatcataga ctgatatcag cagtatatga gtgattcagt tgtttttgcc tctttgccag 72120 catttggtgt tgtcactatt agttcatttt agccatttaa tagaatatat gtacatatat 72180 atgtgtgtat acacaggcac acatctatat aactactcaa catgcctctg gtgagatgac 72240 caacaggtat ctcaaactta acctcttcct aattgacttc tgcatagcac tccagatctg 72300 ctctttcctc actctcctcc atcttgttta acagcagctc cattggccaa aattttggaa 72360 ttttcctcaa tcttttctct ttttcttaca ctccactgtt tatttaaaca gtaaggaaat 72420 ctcgtgaggt cttcagaata tatgcagaat taaatcactt ctctcttgat ccctgccatt 72480 ccccaggtac gggccaccat ctccttaggg cctcctgctt tcactcttcc catccctcat 72540 tctgtttcaa cacagcgtcc agagtgatac tttaaaaatg aagtctgata gatcatgtct 72600 tcggctcaga accatctagt agcatgccat ttcattctaa ataaaggcaa aagtccttat 72660 gatgagttac cgatcctcat gtaatctggc cttccatttt ccctctgatc tcattctcta 72720 ctggtctcct cattcaccgg atgcagccac accaccctcc ttgtttttct tcggacattc 72780 caggcatgct tcagtgcctg ggctttgcgc ctgctgcttc ctctccctga atacgtttcc 72840 cccacattgt ctataggatg ttctcccata cttctctcag atctcttgga tttaggcctc 72900 ctgggccacc atatttgaaa tatcagatta gttccccctc ccccatcatt cagcattcct 72960 cgtaaatctt tgctgtttta aaaatagcac tatcactgtc taacttactg tgttatattt 73020 tgttaatttt ctgtgagttc ttcttcacta gaatattctt tgtagggagg agtttttgat 73080 tgtttggttt ataaaatctg gaacaatacc tggcttatag gaggtgctca atttataatg 73140 gggtgaatga atgaatgaat gatgatgaga aagctgagaa tcagtaaagt gactttccaa 73200 aacaggtagt gggcagtata gagttgggcc ataaatagct gcaccataca acatcctgct 73260 agtttctaaa gcaaatgatt tgaaagaggc ataaaacata atttctgccc tcaggtagct 73320 catagttcag taaaggagtt tagattcata cctataacag tagaagtaat agcaccaaat 73380 gaaatatggt attatgaagt ggtacaaata atataaaaag atgaacagtg ttagtagtac 73440 atgtttagaa gggatttctg tggtgaaagt cactaggcac agtgcacctg gaggaccgat 73500 ttccattaat ttagaatggt ttaaagtaag cttttggaaa ctaggaagat tactttctgt 73560 aatcctttcc taggcctttg attctagaag gattgtgtta aaggagtttt aaatatttta 73620 tacagttctt aaacattgtt aagcttgaat taaatctttt attatgtctg gccatggacg 73680 tcattggatc attttcattt cttgggagga ttaataaagc acattccttc tgttgggcct 73740 ccagtgcggg gagggtgttg gccgagcagt ggctgagaaa acgtttttcc cctggtgttt 73800 tcaagaaccc tctttattag ctaagtggtg agacatgcca cctggtggtt atagtagtat 73860 catttttctc actgttcttg gtgcttttct tctcgttctg attccagtta tactaggaca 73920 actgctataa acctggaatg tttcacacta tattatttca gtaatttcaa aaacagcaga 73980 aatcactaag ctgtttggca caaagattcc tatttggaag gaatcagaca aagtgagtgt 74040 tgagaaagaa cagccaggca gaaagctttg catcagtctt aaagttcttt acatttcaag 74100 taagaggaat tgtgaaatcc ataagacatg tggggttttt ctattacttt ctccccagta 74160 tctattacaa agatcagcac atagtaggta ctcagtaact atttagaatg agtgcatgaa 74220 tgaatgaagt atgtgtgatg ttatggagta caaagttaga attagcaaca tgacctgaat 74280 ttagaagcag gtgggatact tatacttttc tcagtctgtg ggcaccacac cattgaagta 74340 tatgtctaag attaatttat atttggttgt ttgatttagc aaaacttgct gcctgttaaa 74400 aaagaaatta agacctgtca acttaaagaa tacattttgt gagttaagaa ctaaatgaca 74460 gtataattta ttacccaaag cagtttgctt ctgaaaatta aagagttcaa gctattaata 74520 attatgctgt gactgcaggc ataaactggg aatgtcctgg caaatgagga tgtattgtca 74580 cctttctcag cctgcctgtg tgttgttttt aagcttcact ctagtttata tattttaaat 74640 gtcataaaat accacatact tataagagaa aaggttctat tcattgctga agtggaagct 74700 tatcattaat ttttatttat ttattttttt ttccagtttt ggaattctta ttactttgaa 74760 cccaagaacc actgataact agcacaatcc agtgaaacag aggaagcagc agcttaatca 74820 aaggaaaaat acatttaaga ttataagtct ggttataagc ttaaaaagtg acccagaaag 74880 ggatatcatt gctaaaaaaa aaaatcccct tgtgacctgg gtacattttg caaagccaca 74940 ggtttgcagt gttacacaag ggccaaagga ggccatgagt tgtctttggt tgtggggccg 75000 gagggtaact gttcatgaaa atagtgagtg tctgaagatt aagaaaatca tgctgcagca 75060 gaggagaagg gagaggaagg caggaaggga aaggagatgc ctgagggtca aaagctgagc 75120 ccaagcctaa gcccaagctc aagttcaagc cccagcatgg cacaattttg tgaattaact 75180 caggctgagt tgcctccagt ctttggaatg tcatcttata ctggtactgc tgaggcagag 75240 ggcagtaatt ggttctttgg gataggagaa ggggcagttg ctgaaataca aaattaatag 75300 tcagcatccc aagttcctca attgcagcca aaatacatgt gttcaggcct ttcggcagta 75360 ccgcccccag aactaccagc tgtagtgtgg tctattccca gacagcaaca tgcaagaata 75420 agtttacaat acactcagcc cttgtggctt aagatcaggg gctcagaggc tgtgacaact 75480 catgatgctg aaaatgtatc caatgaaaac gaagtactag cttgtttagt agtaacgaag 75540 tactattaat ttttaatata gtctgatact ttattttcta attgtagaag caacattctt 75600 agctatatct ttctagaatg ttgaggcaaa agagtaaatt tatagtgatt ttcactgtta 75660 ccagattgct ggaataggga atttctggta gcaagatggg aatttttaag ttggaagggt 75720 ctaacacatc atatagccgt ctccatctca ttttttttgc tgaaaaaact gagcccttgc 75780 aaatgtcagt tgcaaatctg ggagtagtac tcatgtctct gaagttgtta tatagaattc 75840 tttttattta ttttaataac aatatttatg atagttgaaa ctttttgagt gcttactata 75900 ttttatttca tgcattatgt tcagcacttt acatgtttta tctcacttga tattcacaac 75960 tttatgagat tggcactgtt attgtagcca ttttatagat gaggaaactg aagcttagag 76020 agttaaataa agagctcaaa atctcacatc tagtaagtgg caaaaacagg atttcagctc 76080 aagcaatctg attccaaaac agactttttt cactgtgctg ccattctttt gcctggtttt 76140 tctgttaact tcttaaatat atgtcatgtt tcatgcttac ttcctcattt tcataaatat 76200 attacctgct cacttataca ttatattgct tagaaacaaa cccaaccctg ttttcttatg 76260 gactgtatcc tgaaaatcac tgtttttaat atgtggttaa acaagtgttt tattagtgca 76320 tttatataaa ttatttaacc aaaacactta accggtgaaa gtgctttact gtgtgagaat 76380 gtgcatgttc taagaacctc taatttttaa acctccctta ttctcagcct tatatttgtt 76440 aaaacctgtg tgttaacaca gatgcaccca tgttaggggt taattagaga aaccaacctc 76500 tttatagatt agcttgttca tctttaagtt gctaggcagg cactgtaaat tcagagaaca 76560 atctgattgt aagccacaaa tcaatgaaat taattttggg gttgcctttt aaaatagtgt 76620 cacaaaattt aaggataaag aatgcaaaaa tgatgccaat tatctcatca cattagtttt 76680 gatttaattt ttttaatttg aaaaaaccta ctcttaaact taattgattt ttttaaatat 76740 aagtttggag ataattttta attcagtaaa gttatagtga ttgaaaaagt agtttataat 76800 ttttaataaa ttgatcttgt tttaattttg agtcatattc tagaagtgct tctttgcaaa 76860 ttggtaaatt gcacatacat ttccacttat atacaagata attgctatgg ttggtttgta 76920 taatagatgc agtgcatctg aagagctatt ttatgagaat attgtttctt gtatctgtca 76980 cgagccaaaa agaatatttt taagaaagtt atattcttgg tgatagaaca gctgataatt 77040 tagaaacaac tgtaagacag tccacttttt ctgattatga aataatacca tagttaagtg 77100 taatttccta taatagaata aaaacacgag ttctagtttt aggggaggca tgttgttacc 77160 gtaccttaga atttctggaa gatgacatat tcatgctttt cctgataact gctgagtctc 77220 ctgctctgtc tgccaatcca gtcaagaagc ctttgctagc aatcaattaa taatacgttt 77280 catttataca tatttcctat atatagtatg ttattgatta tctcagtacc actgaagaga 77340 ggttatctgg gtcattggag ctttgcttct agatttgtga agccataaac ctatatattt 77400 aaaataggag gccaaaaaaa aacgaccatt gctttatata gttagatttt cagtgaattg 77460 agagtttatc atttgtaatt atacattaat caaatataag gcataatata cccccctgct 77520 tatatcagca ccatttcaaa tgtaatgtta aaaaataata aatggagaag tagatagcta 77580 acaagtaggc ttaatttaat aagacaaagt aaatggcatt tggaaacctc atggatttaa 77640 tgttttattt aaatgatttc tgatttttaa aaagtaaata ttgtttccag aaggctgaga 77700 aacaagttag tagggagatt ttttctttgc aaaaaaattt tacagttgtg tctttaacat 77760 tgtaccacaa actgttgtcc taccagtctc tttgtaagaa agctatagac atgttgggaa 77820 tgaatgagct ctttcctttt taaaatatca gttttacatc attcaggttc caatcgttgc 77880 acttactgct actgcaagtt cttcaatccg ggaagacatt gtacgttgct taaatctgag 77940 aaatcctcag atcacctgta ctggttttga tcgaccaaac ctgtatttag aagttaggcg 78000 aaaaacaggg aatatccttc aggatctgca gccatttctt gtcaaaacaa ggtaaggatt 78060 taatggttga tgaattttgg taatgatttc cttttttttt ttttaacaac ttatgtattt 78120 tatgttattt acgatttcct tctaatgcat atttaacata tttcaaattc cacctagttt 78180 tggttcaagt caagcatgat gttatataat caattcagtg attgagacta gtgtattttt 78240 aaaagcagaa accaattctc ctaatatttt aataccccat tctgttgctt aaacagggca 78300 tatactattt atttttattt tttaaaattt tacttattta tttatagaga cagggtctct 78360 ctgtcgtcca ggctggagtg cagtggtgtg atcacaactc actgcagcct caaactcctg 78420 ggttcaagca gtcctcctgc ctcagtctcc caagtagctg gaactacagt cttgcaccac 78480 catgcctggc taggacatat acttttaatg attgataagt aaacaagcaa acataaaatg 78540 actctttcat ctgaattctg tctagtttac taattacatg acttcagtct taaggagctt 78600 agaaaaggtc accttacaaa cacagtggag cctgtattgt gttccaagga ctattgtagg 78660 cgctttctat ataaaatgat ctaatttaat ccctataact gctcagtaag ttacgtatta 78720 ttttcatttt attgttgagg aaactggcat tagtactttt ttctgtttat tttgtttaaa 78780 ggcattttaa atatatatgt taagaagttt tcaaaagcct atattttact ttttataagc 78840 ctttatttta ctatttgaga cagtgtcttg ctctgtcacc caggctggag tgcagtggcg 78900 caatcccggc tcactacaac ttccacctcc tgggttcaag ctattctcct gcctcagtct 78960 cccaagtagc tgaaattaca ggtgtgcgcc accatgccag gctaattttt gtatttttta 79020 gtggagacgg ggtttcacca tggtggccag gctgatctcg aactcctgac ctcaagtgat 79080 ccacctgtgt tggccttcca aagtgctgga attacaggtg ttggccactg cgcctggcca 79140 gtttataatt ttaaacatta aaataaatgc ttcttgtcca atcatggtgt ctcacaccca 79200 gaatcccagc actttgggag gcagacgttg gagaatcact tgaggccagg agttcgagac 79260 cagcctgggc aacatggtga atccctgtct ctacaaaaaa tacaaaaatt agctgggcat 79320 ggtggtgcat gcctgtagtc ccagctattt gggaggctga ggtgggagga tcatttgagc 79380 ccaggatgtt ggggctgcag tgagctgaga tcacaccact gtactccagg ctggatgaca 79440 gagcaaggcc ccgtttcaaa aaaaaaaaaa aagcttctac caatacaaac acaaaacaag 79500 catagacaaa tagagtttaa agaacatcat tggtgttttc ctctaaaggg aatattgatg 79560 ctaggccaag aaaatcctgg agttattctt gaggacctta aggaataatt gaaatgtagg 79620 atttgctcct ggctttcttg tcctatattc agaataaaac aagaatggat cgaatatatt 79680 ctgagtgttc tggccattct agtgctctct gaagtgagta ctcactgtgt ttcacttccc 79740 tttcatccta aagaggaaaa gttcttttga agaaggctgt ttgtcctagg ttagagtctc 79800 cacagtcaga tcattatctc ctcctaatct ttgatcctgt tcagtctcta tggtactttc 79860 ccttataata acactctcta tggcactttc ccttataata acactctcct ttttaaagca 79920 gtttgccttt tttgtgtgta atattgttct cctggttttc tgacgtcctg gtcctcttat 79980 aatcctatgc aaatgtttct ttctgttttt catgttgact ctgctaattg aggtctttgt 80040 tactttttag ccgagactat tataatttcc ccaacagata cccctctccc cagtgcccct 80100 tgttgctttc tatgcagttt acaaattatt gtctgcaaac acatccttaa gtctggaata 80160 cctttctgga actccttact aggaaataaa gaccagactc agtgtaacat tcaacagtat 80220 tgaagatcta ggtatttaat atgaattttt ttttttaagg agatcaagaa agatttttgt 80280 acccattttt aatcctccaa gaagacttag gatagcagga aaccattgag agtcagaatg 80340 ctttctacag atcttaggtg aacagaaact ttcctcttca tgagcagtga ggtagagggt 80400 aattaaggct tcagagcatt gcccgttatt tccatcttct tcccttcctt taattctgct 80460 aaattccttt aatttgttta tcagtattca agtattttta tccattgagc taaggtgttt 80520 cttaaactaa ccctattttg ttaaagtctt aattataata tattcatagt acatttaagt 80580 gagatagatg agtctctcat ataatttagt ggttagatta gattagaatt ttctcccctc 80640 agaaaattaa gaggaaataa aagtctgtag caaatcactt ggcaaaataa tggctccttt 80700 tgtaatagga atttttactc ttttgattta tctgttacat aagttcaaat ttttacatat 80760 tttccacctt ttttaaaaaa gagtgatatg tagtcaatat caatttgagc aacactgttg 80820 catataaatt gaaaaggact ccaattttct aattccgtac ctcagttgtg atcactgttg 80880 gtattttggc atttatgtag acttcctttc tctgacccta ctactgtgca gatatatagt 80940 tgcagttttt tgttgttgtt aagttgatac agaaatagtt gcatactata tccattattt 81000 atgcaaattt tttttcattt aaagtatctg ctatctttcc atatattgca ttttcttaaa 81060 ttagagcctt aatatatagg atattacaat atctaggttt tgttgagtag ttttttcttc 81120 tttgaaaaca tgtttttaaa ataaggtttt tttttttttt tttttgacat ggagtcttgc 81180 tctgtcgccc aggctgtaat gcagtggcgg gatcttggct cgttgcagcc tctgcctcct 81240 gggttccagc gattctcctg cctcagcctc ctgggtagct gggattacag gtgcatgcca 81300 ccatgccctg ctaatttttg tatttttagt agagacgggg tttcaccttg ttggccaggc 81360 tggtctcgaa cttctgagct caggtaatcc gcccgccttg gcatcccaaa gtgctgggat 81420 tacaggcgtg agccactgtg ctggccttaa aataagattt ttatacacta aaagaaaact 81480 tacatttttc actccattaa gtagttcact gtgaattttt gatattgaag cccatttggt 81540 tgctgtcaaa aatagatttg aacagattat tcagtatgac tcttgtagtg aaattattgc 81600 cttgtttcct ctgcttaagt tttcagtggc ttttgccaca gtccttaaag gttttataat 81660 ttttttaatg tttaattttt aaatgtttgc ttaatatttc ttagtatgag tgtagataat 81720 gatgaacatt tagatgactt tttactatta taatgttgca gtgaatattt gtttacattt 81780 atcttttggc caataagcaa atatttttgt aaattagaat cctaaaattg aaattggatc 81840 aaaagttata tgcacttgaa attgattaac ttttcctaaa tctaaaatag tatagtcttt 81900 tttatattgt cagcataaat gaatgcactt atgtaaatga atatttttag gcgttaagta 81960 aaatattctg tggaaattga acatttaagt tgtttatact tctatggaaa tcgtttacgc 82020 ttttaataaa gaagcacaag tttctacaaa atacattcta acagatgttt tctataacat 82080 tcagtctcaa gattactagt aaatacttct ttgaactgta aaagcaatct ttcaatatta 82140 taagaaagct cttgctttag taaacattta gaaactcagc tttattatca taagcaagaa 82200 taagaacagt gtaacaagtt ttatgcacac tcctttgtaa accctcacca gactaattgt 82260 taatctggtg ccttgcattc cccaaagtat ttgtatctgt cgtttataag tttttatcaa 82320 ggtttcagct aaaacaaata aatttgtttc tggttttagc tttaatttga actgaaacag 82380 tcaaaactga gttttgggga cttcacacaa ttcatttgga tatttgattc tccataatgt 82440 tttaaatttt catgcactta aatatatcat tatttttgat aggctttctt cctttagtct 82500 tttctttaga aggtagaaag gaagaattaa ataagataaa accaaacggg tctgaagcat 82560 gtataaagta tatatgtttg ctcttttgtt cttctttttc tttagttccc actgggaatt 82620 tgaaggtcca acaatcatct actgtccttc tagaaaaatg acacaacaag ttacaggtga 82680 acttaggaaa ctgaatctat cctgtggaac ataccatgcg ggcatgagtt ttagcacaag 82740 gaaagacatt catcataggt ttgtaagaga tgaaattcag gtatgaggat caatcatcat 82800 tgctctccgt tgctcatagt ggaagtggat atttctcaaa tgtttattta ccagatcttt 82860 attgaatact ttctttgtgt tgaacataaa gcagtccctc tgataaatgt gggagaacaa 82920 acttgcagat tagtataaat agcaatctgt acctagtgct taggtgcaca gaggagggag 82980 gaatagctct gtcaaggtag ttgtgtaatg ggggtggtcc atccaggaaa attcaattag 83040 agtccaaaca tgtaagtaga agtttttcaa gtatgccagg ccagtaggtg atgaggggaa 83100 aggaattggt tatagaattc caggaagaag gactagcagg tgcaaagaca ctttgatatg 83160 agaacacata ctgggttcag gaaatgtgac tggtatggaa tggttggagg gaaagacaat 83220 gtggggtagg aatggcacaa agtatggaca aagaggcagg gtggaaccgt tagagacttg 83280 agagaacagt tgaatgggtc ggttggccag gttatagatg gctttaaaac ttgcaaagaa 83340 gcagtctggg cttggtatca tatacctgtt agttttcact gactacttta gccttagaat 83400 ttttagttta gatacaattt tctgtaatag gtaaaacgga ttaaagtaga ataactctgg 83460 ctgaagttaa tgtgagggaa aaggaggtac aagagtctcg tctctagacc ttgaagacac 83520 tccctgttgg ggtcttataa tccttggagt gccgcagaat catttgaaaa ccatcttgat 83580 gtactactct gtgtttttaa ataagataat aggattatag aaacattaga ctggcagcaa 83640 taagttggat tgatttgaag aagagaaact gaagaaggga aagggtatcg atgcagctat 83700 tgtgaaattc tacagttgag attcctgacc tgattggact ggctcagtgg gtgtcataga 83760 ggatttattt gggaggattt aagttcaagg cacatgagta ggtttaagtc aacaacttga 83820 cactgtcaac atgaaatcca cactgtaact ataagtccga ggaagagccc tctcctgaag 83880 ttaggaattt aacttcagct cttgcatttt ctgtcccacc ggtcatccat ttcttctcta 83940 tccatctcct tttctgatat ctagttgtta tcagtgttgt tgaaaagctt aagtatgatt 84000 catattcact gtctataaag ttcactacac atagtcatgc tgtaatgcat acccgcctga 84060 aagcatctgg tctctctttt ccttctttcc aaagataaga ataccattca cagctgttta 84120 gaatagaaat tttatccaaa ttcttcagtg tttatatttt tgttctgtta tttcagtgtc 84180 ttgaatattg tcaaatgaca tttattagct actactggta ctactgaatc ttaataatca 84240 atcttcaagc cattaactga ccaatggttt cttctatctt aatgtattag taattattca 84300 tttagagtaa aacatctccc agaacatgaa agaatacaaa ctttattcat gttacgttgt 84360 gacaggagac tttgttggat gcgcctgatt ttcctgccaa ttcacagctt cattaaaaca 84420 gtaatgcttt gaaatatggc ttaggaaact tcacaatgat cattaattac acctaatttc 84480 tggaagagta tatgcatgta tgtgttgcgg tattctccct tgctgtggca ggatgtcaca 84540 aatttttatc cacattacga aaatttaaaa attgatatgg ttttttctcc ctacgttgat 84600 atcagatatt ttgttttatc tgacagctgg cccaatgtac tcctactttg ccattataaa 84660 gaattcaaaa gcttcatatt tgcattgaaa gttctcaaac actttgtaaa gatgatgaaa 84720 gtatgtttca tcatctatgt agaatagtca ggtgttcttg caattgatta cttgctaccg 84780 agaattgaat acctactgag tgcataatgt atagaattct agatattcac ttttgtgtgt 84840 ttttacagtt gttatatacc ttagtgtggc tctaaaagtg gaggtgacag ctgtagctct 84900 taatgtctta cactgagtga tgtttagaat cttaaatttt cttttataat tttagaaaaa 84960 agtatacttt tctttcttat ttttataacc agatccaaac acatttgcat gtagataggc 85020 atttttagtc ttgaacattc atttttactt ttaatcctca cttttattag tttcgtatct 85080 ttttgtattt catttcccct ttcaagatgc cttgagtcct ttctttttag gaatgatgtt 85140 gtgaataaat tatttgataa aatgtcttta cacctgagag tttataagga tagtttgaaa 85200 atcatgtctg taaaataggt tgatctcacc taaaaataat accatataat taaaattaga 85260 attattattg tgttgcttat tgactcttac atatatcaaa aaattgctga gtcttattca 85320 gccagagctt ttacttagta tgatattcat tcctatattt acttttttct cacctttctc 85380 atactttctt ttacttactc agcattttcc tcctttcctc cctcctttct tttcttcttt 85440 ccttcttttc tcttcctttc gtattcctgg tccatcttag catgtaatct ttctttatga 85500 aatggcatgc agataggtct actgttctta cagtaaaaaa cttcaaggcc tcatgtcttt 85560 cccacttctg tttcccattc acaacctttt tagctgattc ttttggtact ttaccactat 85620 atcttgccat agtttatgta cctggctcct acttaatttt ttgtttattt gtgtattagt 85680 cgtaggcatt atttatcgac tcttctctct gaaagatgaa aggttagctc tctttcacat 85740 tcttaactgc ccttttttct taccttgtcc atgtatttct aacccccttt cctcctaata 85800 tgtttatgtc ataattttgg ctagattagt gtatacgatt tacataatta ttactctgta 85860 aatgcttttt atgatctctg agccatgtag tatattatgg ctatttttct ttcttatcta 85920 tttgtatttt tattgttatt acctaaaaaa aaattttcta tgtcttatca ctaattcttc 85980 cctaaaattt cccacaattg tgtaaactta cctcagtata ttcatagata tgagacattc 86040 tatcaatttt accctcttaa agatgcagag ataatgcatt atgtttcatc ccaccatctt 86100 taatgagaag cttccatctt agattaatat tagagaatgt taaaatactc tgcaatcagg 86160 taaggacgct tgaaacttca ttataatgca aaagttttct ttaacacaat aaatattttg 86220 aacccctttt gtgtcttgta ttcataggag ttcagataga ccactttatt tactattttt 86280 tatagagagt gaacagaaat cccatttcta gtcaccagtc cttaatctgt aaatcaggca 86340 gataatctgt aaatgattgg ttgaaatcac attgaattcc actttgtgcc agggacttaa 86400 gttaacgaac aaattattct tacaaaaagg tataaatgta aggttttcat tctgctaaat 86460 atgtttgtca aactgtgttg tgatttgttc tcagtgtgtc atagctacca tagcttttgg 86520 aatgggcatt aataaagctg acattcgcca agtcattcat tacggtgctc ctaaggacat 86580 ggaatcatat tatcaggaga ttggtagagc tggtcgtgat ggacttcaaa gttcttgtca 86640 cgtcctctgg gctcctgcag acattaactt aaataggtaa aaaaaattta ttgtttttac 86700 tcttgcagat ttctttcttt ctttccatat aaacctcaaa agtgtttgag gctatttcca 86760 gtatcccaag taatttgtga gtgcatttaa agtaaaaaaa aaaaaaaaga aaaataaaac 86820 ctccccaaat ccagaggaca tgtaagaaga acatttgtgg taagagttgc cacttggaga 86880 tgagctaatt tcagcatgcc ttagttagtg tgaggaatta actaaatcag gacaatactt 86940 gggcctgtca cagagatcct atggaatact ttcctaccat tgtgcattaa tgaacaggtt 87000 cttttcctct cctcagatcc tgtcaagttg cgatgtcttc agccatagtt acttcaacta 87060 ccactgattt tgttactgat tctttcttcc catgctacag tggtgattat tccagaggat 87120 ttctctcagt ccctatttga ctcttgttac tatttgtttt cttggttagt tccatgagac 87180 catgccagtt ctccttgact gtgtatgaat cattgtgttg cactgtactg acagactgcc 87240 gtaagtcaat attaagtgtt cagtatctaa gtgcaggaga acctttctac ttaagtactc 87300 aacaagtagt ttgttggcac ttaagttcta tgagattttt tgttgtaaag gaaaacatta 87360 tcttgcaaag attttggggc agcatttacc aatactttgt tccttcatcc gtaggaaaaa 87420 gaatctcagg agaaaaacct atacatggta accaatgggg ctgccaagct gatgaagtat 87480 tttcagagta cacctttgtg tagctgaata aattgagatc ttgaatggac atattagctc 87540 attttagtaa aatgataaga gagtgcctcc cactacagtt tttgttttta tgcatcatta 87600 aacaatgtgt ttttgattgt ccactgtgtt ccatgaacta tgctatgtgt gggagatata 87660 gtagtaaaga aaagcaaagt acctgcttcc atagaattca gtataatggg aatggtaatt 87720 ctttagagaa tcacataact atggatacat aggcttcatt ttactgttct ccttttgtgt 87780 ttgaaaatgt caacaatcaa aattttgtaa aaaaggaatc atgcaacata tttaaaatta 87840 taactgtgtt aagtgtaatg aagggaaatt gcactgagta gtaagaatat ataatggtgt 87900 gtggtatttc ccaagttaaa aaggtcagat aaggcttcct tgtggaagtg atagttcaaa 87960 tctgaaagaa gaataggaat taattaggta aaaatgtttg atgcaaattt taagattttc 88020 cttctgagta gtcagtagct tttccttctt aacatagaag atgacaaaac catccttttt 88080 ttgtacataa caattcttgt tttcctttag acagttgtat ctgtcaagct tcttatgatc 88140 taatttaaat aattgggata gaacacagct gtacatgtta ctattaaata tggaatatat 88200 caaacataag ttgattccta ccagttctga ttttatttgt gtattttgtt aaaggtactg 88260 aggacattaa tatccagttt tatattgtgc atttgaaggt tcatcaataa atacaattct 88320 tgtttctctg ggtcttaaaa gatattttaa atggttatct cattaagatt taacaggaaa 88380 taacagtgat tcaaatcaaa tagtggtgcc agaaacccat acttgaattt tgggtataga 88440 caggttaccc tttgcatcaa tcctgaggaa actaaaacta taggattaat caggataaaa 88500 aagaattgag caaggattca ggagggatct gtatcatcct ggtgacaacc ctcttctaga 88560 aaaaactaga aagtctaaga ataaatgaag ttgctggttc tcacctggaa aggtcagtta 88620 ctcacaaaat ttttagagtc tatcttatgc cataattcta tcactgagag aagaaacttg 88680 tccagtcatc atgtaatctt catgtaaatt tatgttttta attgcagaat tcataccaca 88740 ggcaaagtcc caatgtctgc atttgctgtt accttaaata gtcaaacccc aaagttattg 88800 taatcttttt ttaacagaga ataatttgca gagtaatctc ggtccggtag atctttcagt 88860 ggatccaaat gattgccatg aatggtttag aattttttta attttcaagt tgtttttatt 88920 ctgtggaata ctggacttat ttttgtagtc ccaaaagaaa aataaatatt tatttatttg 88980 ccgttaagag ttgtagtttt gttttctcaa atttgtcctg acactgacga gattagttaa 89040 atgtaggtca tctgaaccaa atacaaggaa ggaaggaccc agttctgaag agtgtgggca 89100 tttcttttct tgtttttttt tttttttttt tttttttcta taggagggga acgaggtgaa 89160 ctaaacaaac aaaataaagc aaaaaagaac tgatttttat cccttgaggt agaaagaatg 89220 agattacagt ggaccccctt gtctgcattt tcactttcta tgttttagtt actcacaacc 89280 acgtccaaaa tgttaaatag aaaattccag aaataaacaa tttataaatt ttaaatcagt 89340 ggtggctttg agtactgtaa tgaaattttg tgccatccca ctcagtctgc ctcgacttcc 89400 cttagaatca tccctttgtc cggtgcattc acgttgtatt tactccctgt ctgttagtca 89460 cttgttgcag tatcacagtg cttgtgttca agtaacgctt attttactta agaatgaccc 89520 caaagcacaa gagtactgtg cctaatttat aaattaaact ttttcatagg tatatacata 89580 taggaaaaaa cataatacat acaggatttg gttggtacta ttctgcggct tcaggcatcc 89640 actggacgtc ttggaatgta tcccttgtgg ataaggagga actgtatatg gttaacctag 89700 gagctagagt caacagttgg aagagacttt ggggataatt acatggaagg gcatggtggg 89760 tggtcgtttc agatgacaag aatgtttttg aataacggat catttgtgtc ttcagacttt 89820 ccagaactcc ttgagaatta tgcagaggta tttaatcagt cagaaggttg aatagtcaaa 89880 ttattagtga gtgaagtcta ttttgatgag gattttacta atgctgtccc ttagatatta 89940 taagtaaatc gttgttttct tttgaaatat ctgaaaccta gttaacatgg actttcattt 90000 gttcttgtaa agatatgcaa agctatttgg gagattgtca tcatctgata tttgatattc 90060 atgggctttc ttcacagaag actagaaatt aacagagtca tgatgaatta tggctgcatt 90120 gactttaaaa aacaaacacc tccttaatgt tatttaacaa ttttgaataa atttgatatg 90180 gcaaacaaat cagttataat cgattgagaa aggaacttaa ttctaatact tgactggtgt 90240 cccataataa cccataatac taagagacag ttttggaggg cgagaagtcc tgaagagctg 90300 atagagataa aggttcaaat ttgagcttct ttcagtgttc cttacgtcaa tgcttttagt 90360 ttctcataca aaataaaata aagaataacc tttttactgg gaaaaggtaa aaattaataa 90420 attgtagaag cattgtttga agccaaaaag tgtgtgacat gtaaattgaa atgaaaaacc 90480 ttagagtttt tgatactttt tcaaagcagc taaagaattg atacttggac acaggaagaa 90540 ttttttttca aaagcaattt ttataaaatc agaaaaatgt ttacctcttg ttgggggcat 90600 tgactggaaa ggaatacaac agaactttct gagatgctag aaatgttttt ttatcttgat 90660 ggggtgtggg ttttgtagat aatgaaaaat aaacagtaaa aaataagtaa aaaaaaaagt 90720 aagaaagttg ccaatacagt tttacatatt cctgtgatgt ttttaatcga caggcacctt 90780 cttactgaga tacgtaatga gaagtttcga ttatacaaat taaagatgat ggcaaagatg 90840 gaaaaatatc ttcattctag cagatgtagg agacagtatg tattatttat tttatgccaa 90900 tagtatggat ttatggatga tgctctttta agacaacaat ttggctaaat aattatcagt 90960 attttgaaaa aatattttgt tgctgttaca tgtgtgctga atttttaagg ctaacttctt 91020 tgtgtctgag taaactgaag tcaaataatg aagtcccaag tgaatcaatt aatggtgatt 91080 ttacctcatt attttcagga atgaacttaa catatacgtt tctgttcttt tatttaattt 91140 aaaattttgt cttgggtaga atcatcttgt ctcattttga ggacaaacaa gtacaaaaag 91200 cctccttggg aattatggga actgaaaaat gctgtgataa ttgcaggtcc aggtaaagat 91260 ttcttattat agatggacat tctaaaagtc tttctttctc ttccttttca tgtttaactg 91320 aatttttgtt gaatgataag tatttcagtt ttttaaacaa aacaatgaat gtgtttagat 91380 atgagaaagc aaacaatatt aaagtatttt gcttaaaaaa tagataaagc aataaaatgg 91440 tagccctaaa tctaaacata tcaatagtta tgttaaatgt aaatgatcta aaatattatt 91500 taaaggcgta aattgtaaga attggtttaa aaacatgacc ctgttctgta cgttgtccac 91560 aagaaatcca ctgtaattat atagataggt ttaaaaaaga atgaaacatt acattccatg 91620 aaaacattaa tcaaaaggaa gttggagtta ctttaatatc agacaatgga cactttggag 91680 caaagaatat tatcaggata aagaaggata ttatatgatg taaaagaatc atttcaccaa 91740 tgtatcagtc agggttcacc agagaaatag gacgattgat attatggaga tatatatata 91800 tatatatata tatatatata tggggaggga aaggaagaac aaatatgggg agagagggat 91860 gaggcgactg attttgaaga attagctcac gaaattgtgg gggttggcaa gtctgaaatt 91920 tgtagagcag gtcaataggc tggaaactca ggcaagaggt gatgttgcag tcttgaggca 91980 gaatttcttc tctagcaaac ctagtttttg ccctttagtc ctgccactga gtggatgagg 92040 cccacccaca ttattgacaa taatctcctt tacttaaagt caactgatta taaatgttaa 92100 tcacgtctac aaaatatttt acagcaacat ctagattagt gtttgaccaa acaactgagc 92160 atcataggct agccaagttg atgcataata ttaatcatca caaccaagaa gacatcatcc 92220 taaatatata tatatatata tatatatata tctacttaac aaaaagactg acagaactga 92280 aaggagaaat agagaaatct acagttacat ttggtgactt ccagcatctc tcaataatca 92340 ataaaactga cagaccaaaa aatcagtaag aagacagaag aaatgaacag gattatcagc 92400 atgctggatc tcattgacct ttttagaaca ttctacccaa caacagtaga gtacacattc 92460 aagtgcagat gcagtattca tgaacatgga tcatattcag agtcataaaa caaaccttaa 92520 caaatttaag aatcttgtat ttgtatattt tttgactaga atggaattaa actagaaaac 92580 aataacagaa agataacaga aaagtctcta aaccttagaa attaaataac acacttataa 92640 ataaatccat gagtcaaaga ggaagtctca aggcaaatca gaaaatgttt tgaactgaat 92700 gaaatgaaaa tacaaaatgt gtgagatgca gctaatgcaa tactgagaag gaaatttata 92760 gcattaaata cctatgtaat aaaagaagaa aggtctcaaa tcagtaccta agcttacatc 92820 ttaagcaaca agcaaataag agcaaaataa atcaaaatga agtaaacata aggaaataac 92880 aaagaacata agtcaatgaa tagaaaagct atggtcatac cactgctgtc cagcctgggt 92940 gacagagtga gaccctatgt caaaaaaatt taaaaacaaa gcagcatgca gcattcattg 93000 tcagtgaata gaaaatggga aaacaataga gaaaatcaac tcaaaagctc attctgtata 93060 aagatcaaca aaattgatat aaacttctaa caagactgac ggaaagagaa aagacacaga 93120 agaccaatac caggaatgaa agagggaatt tcactacaga cctcccaggt attactaggg 93180 atgataaggg aacactatga acaactcaga acataacttt aataatttag atgaaatgga 93240 tcaatttctt gataatctca agctaattaa acttacagtg aattagataa cctgcatagt 93300 gttacaacca ttagagggat tgaattctat gttaaaaatc tctgaaaata aaatccccta 93360 gcccaaagaa tttcaatgac aaattctacc aaacatttag aagacaaaat aataccaatt 93420 ctatagcatg attccattta tataatagtc tttgaaacat aaaactatac tagagggatg 93480 aagaaaagat cagtggttat tagagattgg gggagggaga aggtatgatt ccaaaggata 93540 gtacaaggca gtattttgga gtgatagatt tatcgtgccc tgattgtgat gggagttaga 93600 tgaatctatg gatatcttaa aatgtgtaga actttacaca tacatacaac caatttgcct 93660 atgttaattg aaaaaataaa ataaaaacaa attatttacc tggtgggtta gctacgtacc 93720 taagttcaat agctgcgtta ctgtaagaca aaagaagcat tattagggat ggagttgttc 93780 tctgtgtaat gacaaatact tcttcactaa gaagacagaa ttgttttatg cacctttaaa 93840 aaaaaacaaa aacaaaaaaa atacaaccaa caaacagtaa cttgctggtg cggtggctca 93900 cacttgtagt attagcactt tgggaggctg aggtgggagg atcacttgag accaggattt 93960 ttaagaccag tctgggcaaa aaaccgagac tgtgtctcta caaaaataaa aaataaataa 94020 aaaaaattag ctaggcatag cattatgtgc ctctagtccc agctactctg gaggctaagg 94080 tggaaagatc gcttgagcct ggaaggttga gactgcagtt gcagtgagcc atgatggcac 94140 cactacactc caggctgggc atcagagtaa gactctgtct cacataaaaa aaataataat 94200 aatgataaaa actagtctgg gcatggtggc tcacacctgt agtcccagtc ctttggaagg 94260 ccgaggcaag agaattgctt gaacccaaga ctttgagaac agcctgggca acatagcaag 94320 accccatctc tatttaaaaa aaaaaacaaa cttaaaaatc cagcaaatac ataaagcaca 94380 aagccgacag aagaggtgga gaaatcaaca aatccaccat caaagtggga gaatttgata 94440 taattttaag ttattggtag ggtaaacaat ccaaaaatta gtacactgta gaaaatttgg 94500 tcaacatagt aataagtttg cttattacta tttatcagta tacatagtat actgatttat 94560 cagatacata gtatatggag ccctagagca agcaactata gcagtgtatc tcaagtattt 94620 ttacttcatg acccacatag caaatgatat gtgtatataa cacactgggc taattgtcag 94680 agttcagttt ctgtccaaaa ccctaagatc tggagtgatt aacctttcag cactcttaga 94740 actcacttgt ttgtagcaca ctgattgaga agcactgaaa gacttcactc ctcaaacata 94800 catggaatat ttctaaaaac tatgtattgg gccgggtgca gtggctcatg cctgtaatcc 94860 cagcactttg ggaggccgag gcgggtggat cccgaggtca ggagatcgag accatcctgg 94920 ctaacatgat gaaacgccgt ctctactaaa aatacaaaaa attagccgga tgtggtggcg 94980 agtgcctgta gtcccagcta ctcgggaggc tgaggcagga gaatggtgtg aacccaggag 95040 gcggagcttg cagtgagccg agatcgcgcc actgcactcc agcctgggca acagagcgag 95100 actctgtctc aaaaaaaacc aaccaactga acaaacaaaa aaactaaaaa acaaaaacaa 95160 aaaaactatg tattagagca tgggttggca aactatggcc tgtaggccaa atctgcatgc 95220 tgttttattt ttttttattt ttttgacata gggtcactac aggctgtcac acaggctgga 95280 gagcagtggt atgatcatag ctcactgtaa cctcaaattc ctgggctcaa gcaattctct 95340 tgcctcacct cagcttccca agtagctaca ggcatgcact accagaccca gttaattaaa 95400 acaaattttt ttttggtaga gacagtctca gtatgttgcc caggctggtt ttcaaactcc 95460 ttgcctcaat cagtcctcct acttcagcct cctaaagtgc tgggattata ggcatgagcc 95520 atcacgcttg actaatgttt ttgtaaataa agttttctca gaacacagcc atgccttttg 95580 tttatgtgtt atgtagggct gcctgagtta agtagttggc tgcaaagcct atcatggcct 95640 ataaagcctg aaatacttac tatctggtcc tttatagaaa gtgttttctg accctgtact 95700 agactagctt gtctcaaaat tcttcaatga atttggaagt tttctcacca cattttctga 95760 ccataatgca cttgagttag aagtaaataa gcagataaac aacaaaatcc tcatgcattt 95820 ggaaattaaa aataacactt aaataattca tattcaaaga aaaaatcaaa ctggaaatta 95880 aaaaaaattt taaacctaca gataactaca ttaatatgca ttaacatttt tagaacttag 95940 ggatagttac aatgatatac attaaaactg gtaagaggct gggtgcgttg gctcacgcct 96000 gtaatcccag cactttggga ggccgaggct gggggatcac gaggtcaaga gattgaaacc 96060 atcctggcca acatggtgaa accccgtctc tactaaaaat acaaaaatca gctgggcgtg 96120 gtggcacgcg cctgtagtcc cagctacttg ggaggctgag gcaggagaat cgcttgaacc 96180 tgggaggcgg aggttgccgt gagccgagat tgggccactg cactccagcc tggcgacaga 96240 gcgacactct tgtctcaaaa aaaaaacaaa acaaaacaaa aaaaaaaact agtaagaggg 96300 cccagtggct cacacctgtc attctagctc tttgggagac tgaggagaga ggatcagttg 96360 aggccaggat tcaagaccag tctgggcaac ataacgagac cgcatctcta caaaatttta 96420 ataacaacaa caaaaaaaac tggtaagagg caacattgaa tagtactttg tgggagttta 96480 ttagcttgaa atactcataa tagaaaagaa aattaatcag ctaagcatct cactaaagag 96540 attaggagaa taaacctaag catagttttt ttcccccaaa cattattata tctggaatat 96600 tgaatgcatt cttattgcta tttcaaagat acttactcta aggaaagcaa ttgaattagg 96660 tagttgaact ctatagtaga ttttctttaa tgagtccttt tgttctcaac ctacttaaat 96720 aattctcatt tgaatttatg atagtttcag atctacccaa agggtgactt aggaatttaa 96780 cttctaaatc tatttaaatg aaaggtttat aatctttttg tcatatttta cagtcgttag 96840 cgtttaacaa tttatagcat aggatttggg tttttttttt tttttcattt taaagaagaa 96900 gtttatttaa gcaagacact tgactaaggg aagactatct tggagttatt attactagag 96960 taatttattt ctacttaaag acagattgcc ccacaagtaa cagctacata aaaacagttg 97020 taaaattgtc cttggtttta caatgataaa tgaaaaacat taaaattctc taattgaaca 97080 aggtatgcaa ggatttttat attgtttttt gctaaaacta tgacagcaaa ataacatcct 97140 ggagtataaa gataagagct gaatgagcag gccactaggg gacaaaggga gtcttttcac 97200 agaaccaatg cttcttttgc ccaccccatc tccatcgaag tcaatctaaa catattattg 97260 gccatttagt taaaaaaaga aagaaaagaa aagcaatatg cttgtggaca tacaccagtt 97320 actttatgtg cagtaaaaga gtaggaaggg gaaggtgaaa gaatagagaa aactatgtag 97380 tcaggatgtg gtggaaccaa attgcaactt tctttttttt tgagacagag ttttgctctt 97440 gtcacccagg ctggagtgta gtggtggccc aatcttggct cactgcaacc tccgcctctc 97500 agattcaagc cattctcctg cctcagcctt ctgagtagct gggattacag gtgcatgcca 97560 ccatgcctgg ctaatttttg tatttttagt agagatgggt tttcaccatg ttggccaggc 97620 tggtcttgaa tgcctgactt caagtgatcc acccgcctca gcctcccaaa gtgctgggat 97680 tacaggcgtg agccactgcg cctggccaaa ttgtagcttt ctaattgaga ctgtcttctt 97740 ggtctggaag agcagagttc tgcagtaaaa taacaggtcc cccttttagt agacatctcc 97800 atgtctgctg ctggaacaca tcagttttgt cttaagcctc acttccaaat gtgcagatgt 97860 gtctggttca ttgattggct gcctgtcaaa ttgaaacctg atctgcctca ttggcaaacc 97920 gtgcccctta caataggctt tcattggttt actaagcggt gtggtgcgtg gctgttcatc 97980 ttaaactgca ccacagttta agatgaacct tcaaatgaac attatccttg ttctcagtct 98040 tgactttcct tgggcttttt gtggaccctg gtgagtgtgg cagtctcctc agctgctgct 98100 tcacaaaaga ggtaccaggt ctgccccgaa tgagtgagcc cctaaacagg accaggagtg 98160 gcagaagaaa gaggcagcaa ctgagatgtg ttttttctaa gctgaaaggc tttttttttt 98220 tttttttttg caacacacct ttaacactaa agtccaatat ttatataatt ggtcaagtaa 98280 gtggagctgt tctagctata aatatggcaa ctctgcttgc tcgtcctatt attgacatta 98340 ttcctttctg tggtctgagg tgcctcccat gaaacttgct tctaggacac taggattgag 98400 aaccatcagc gtaacatatc tgttacgcta caatagttta ttttcatatt ttagctactt 98460 tacatactcg ggtataatga actttattca tagcttctga agcagttggc acatttgaga 98520 tattttttac ttggctaatt gttatgctaa atcttttgat ttctaaagat acatgccttt 98580 gctaagcttt cttcaaatgt tattattttt atttagattg gatcattgct attccatgga 98640 tgactcagag gatacatcct gggactttgg tccacaagca tttaagcttt tgtctgctgt 98700 ggacatctta ggcgaaaaat ttggaattgg gcttccaatt ttatttctcc gaggatctgt 98760 aagtatatat ctgtgaattc ccttcataga tcttctttta cttctattac acttttcttc 98820 agaggtttgc agtattatga ttgtagcttt gacttcagat gggtgactag gaactcatag 98880 agtcttacta agttccagtt aaacactaca ttcattactt tggataaaac ccgtgtgtat 98940 ggcatcttct gctgttttca tgttcaagcc gatgttcagc tctgcagctc agtctggaag 99000 cattgtgtta atttatcaca ttgcatttgg gtgaatccct agactagtct tgcttaggat 99060 aattaggaaa agttaacttt cattgtatca agggacaggt agaacaaaat tgtccttttg 99120 tccaggaaac cattaaattc ttcaaggaaa actttagtta tagggattat tttttaaatg 99180 tctaatttca gtaacaatat ttgggacata tttatttttc cttctgtttc ctatcagaag 99240 tatttaaagt tataagaaaa ttgtggtttt tgcctttact aatgaataaa taatcaatta 99300 aattcagtta cttttttttg gagtgattga tgttccagta ttcttctaaa caaccacggg 99360 tacaaatgtg aataagatag gaccgttgca gtccaagagc ttgttctgta gtcctttcct 99420 ttatatgatt ttttcccctg atttagaagt ctataaagca aagctaagta ttacacactg 99480 ataatggctg aataaatcaa gagcaagaga taggatactt tgcaaatatg catatttatt 99540 aaaaatgtac tttaaaatag agattaaaat tctcgtattg aatgtagaat aggtaagcat 99600 ttatttgtga aatactcgaa tgcttcatgt aaatactttc tgagtttgta tttttagaaa 99660 ggaacatttt ggaggctgag gcaggagaat ggcgtgaacg tgggaggcgg agcttgcagt 99720 gagctgagat tgtgccactg cactccagcc tgcgcgacag agcaagattc tgtctcaata 99780 aaaaaaaaaa aagaaacata tttattaaat tagttgtgaa atatttttaa tgaaatatat 99840 tgaaaacttc tgttgatttt tcatgtactg atgtttttag attctaaatg gagtttaaaa 99900 ttttgtttgt aaatcacaag ttggattaga aatttaatag tagaagtgtt gcctaaggac 99960 tattttaggt gctgtgagtg aaactgtatt ttttataaca agaattttag ttgtaaggga 100020 cagcttaaat ataattgaga tctgtgaaaa tgtattctgt ctctatcacc ttcagaacct 100080 gtgtatctca gttgaatgta taatttataa aaattattct tgttttaatt tggtgtaatc 100140 cagccatatc cagtatcaac aaataagtct aagtaggctc cttgacaaac ttgaactggc 100200 cacaagagag atcagatttc acctattaaa aaaccaaatc agaccactta cactgacagt 100260 ctcttctggg agtcctcaaa ttaagaagtc tatcctttgt gaaatattac actacccttg 100320 ctagataaaa cttttctaaa agtaccactt aatgaaaatc tgtagacact aaatgcaatg 100380 aaaataaggc attgtttttt tttctcccca tttcagtgat cttggtatcc tgggatattg 100440 tttttaaaat tatcgttata attcctttga gaatttagtg aaatgttccc tttaaccaac 100500 ttaggaaaaa ttaatatctt tgtacatgat tttgagctgt aaaataaaca ttttaaactg 100560 ggaataattg gagtttagtt aaagagataa tgtatataaa tatataacat agtagcagca 100620 tataattctg tcttacacaa gatttttctg aatagtataa acagttatgt agcctatcta 100680 ggagtttgtg aatagagttt aaaattttgt tttgaagctg caaatttgat tagaaattaa 100740 acagtgaagt tattacttaa ggaacttcgt tttagctgtc tgaacaactt actgtataaa 100800 aatctttaaa cattctgtat aaatatgtga taagatatgc aatgacctta attttataga 100860 ttagaaaata aaaacacact cattaattta cataactgac agattaagtg aaacttctct 100920 tctgatcacg ttagcagaat gccaaatctt gtcgtggcac tagaattaga cggtagtttt 100980 gataatacat gatttgacta tagacatttg ttgaaactat tggtagtttt aatcactctt 101040 gtaattttca aactatctaa cgggagagga ttatccatcc tgttttctag acaaactgtt 101100 tcatctgaat gaaatatatt cctagagata attatcacta cttcatcttt tggttttatt 101160 ttgcacatag aattatagtt cacaatgact ttctgaagct ctaaagttgc agctgtgagc 101220 ttctttggcc tgtagggact gggaaaaagc acccccgtcc tcccccaagc ccccccacca 101280 aaaaaagtta aagtgttttt aacaatagct gtgggctttt tgtagtttca gaacttagga 101340 gttgcccagg ctggaatgca gtggtgtgat catagcttga tgcagccttg aactcctggg 101400 ttcaagcaat cctcccacct cagcctccag agtagctggg accacaggtg ccaccccacc 101460 cagctatttt ttttattttt taattttttt gtaggtatgg ggtctcccca tgttgccctg 101520 cctgtctcaa actccagggc tctcaggtga tacccaccac ccttggcctc ccaaagcacc 101580 gagagtcact gtgccaggct gagtttaaaa tttcttgagt tggagtttat ggctattttt 101640 tccactagtt attaaacatg tatttttgta taaggcactg tattacattt tgtgggggga 101700 ttcaaagcta aattagatga gacgcatcat ctattatgga agatgttact taagaagaaa 101760 tgagtgtaat gtagcagaga attagataag ggacgtatga atacatataa atgctgttga 101820 agttctgaag agagagagtg tttagagaaa ttagaggagt ctttgtgaag gtatcactag 101880 aacttcctat ttttgtggaa tatatagtag attttggtgt gatactgtgg atttggacat 101940 tcactcagag aaggaatgag ggaagaatgg tggagaagaa tggcattcac agtacaaaaa 102000 gcaactgtga cttttaaaga agttaatatg gagaagtggc aagtcttttc ttctctcttc 102060 tcttctcttc tctcttcttt ttcttttttc tttttttctc tgtcagatac cgttgtaaag 102120 actttgcttt taccggaaac tgatacgttg ggtcatgtac cctggccagt cagttctctt 102180 tattctaaca cttagccgat cagttagatt tccacattcc atgatatgtc agttttggtg 102240 acccttattt ttccacctgg tttataaagg gaaagaatgt gatatgtcac ccaggctctg 102300 gagtacagtg gcatgatcat aggtcacagc agcctcaaag tttccagttc aagcgatcct 102360 acttccttgg cttcctgagt atgtggcact acaggtgcat gccaccatgc ccagctaact 102420 tttttgtaga gacagggtct ccctatgttt cccaggctgg tcttgaaccc ctgacctcaa 102480 gtgatccgcc caccttggct tcccaagata ttggcattac aggcatgagc cactgtgccg 102540 gcctgaaaat ttctcttttg agatggcatc ccacagaagt atacctgctt agagctaaca 102600 ctggtaaaaa gactatttaa ccctattgcc ttattttact gtagttgaga ttgagttaaa 102660 ctgaaagctg aatgacctgt cctaggtcat actgttactt tgtgccagag tcaggatgag 102720 caaatggatt tcctgcctgc tagtctagtg tcttttctat ttattgtgct gtaacataca 102780 gttttaaatt tgtattttta tgcccaatgg acatggtagc tcacacctgt aatttcagca 102840 cttttgggaa gccgaggtgg ggggattgct cgagaccagg agttcaagat gagcctgggc 102900 aacatagcga gactccgtct ctataaaaaa aaatttaaaa attagctgag tggtgatgtg 102960 tgtgcgtgta gtcctccttg tgggaggttg aggtgggagg atcgattgaa tctaggaatt 103020 caggactgca gtgagccatg attacaccac tgcactccag cctgggtgac agagcaatac 103080 cctgtctcga atgaatgaat gaatgaatga atgaatgaat gaatgcccaa atccgtaagc 103140 tatgttctgt atagcagctt tttcatcata ggcagttttt actcttatca gtggacaacc 103200 tacaaaatta actaaacact taaacaatta acagaggagg ccttgttcag agtgagaaat 103260 cattaagcat ttgttgttga aatttcttac tgtactctgt tttaattctg tttttttttt 103320 tttttaatgt tacttgtttt agtttggatt cctagttgaa aagggaatat gattccttta 103380 aaacaaagat actctgcttt aaagcaaagg tatatcatcc tcttcatggt gattgccatg 103440 gaaacaagac aatgtaaatt tattcaaata gtacacagtt tttatagtta ttgatcatga 103500 ggggaaggga cagttaatcc ctactgatca gataaaacct cattgtttca tactaataaa 103560 tggttttttt atgcttatga aaggaaaagc cagaagtgta atttttagtg tttagagagc 103620 tagtgattct agttagggaa cttaatacct ttgaagttat tagtttgcaa gcaatagaat 103680 ctactactac caaggtgacc cctagcagat gtagagtacc attaacaagt gttccaggga 103740 aggaaagcca actagatacc aagtcatgct ttttactctt agattaagaa attcaggttg 103800 agttaaagga tcagctgtta actaataaaa agcagattaa tattacagag ccaggctctg 103860 tcctggttat ggacttaatc ttcacagcat cctcaagaga taaaaatgaa tatacctgca 103920 tattagatga ggaaatagaa gataagtaac ttgccagagc tatgacgtga actcaggtaa 103980 tgtagcttaa gagcccccac atgtatgtat attgggtgtg tgtgtggagg gggtgcgtgt 104040 gagtgcttgt gcatgcgtgt ggtataataa gaaaaaatta gcatttatgc ctgtaatccc 104100 agcactttgg gagaccgagg cacgaggatc tctcaacccc aggagttcaa gaccagtcta 104160 ggcaacatag cgagacccta cctctacaaa aaaagtttta aaaatattag cgggcatggt 104220 ggaatacacc tgtagtctca gctgcttggg acgctgaggt gggaggatcc ttgagtccag 104280 gagattgagg ctacagtgag ctatgatgac acctctgcac tccagcttgg gtgacaaaga 104340 gagaccctgt ctccaaaaaa aaaaattaga actagttatc tggaggcctg tgttctagtc 104400 ctagctttag tacggctaca cagtgacaca ttaggctacc atttaacatc tttgaacctc 104460 tgataatttg ttaacaatat gggtaaaaat gactaagata aatcaaagag ctccagcatt 104520 ccctccagct ctgaaattct atgatgtttt atcttatttt acttacaaaa ataaattata 104580 ttatgtatat ttaaagtata caatttgatg ttatgggtta cctatagtaa aatgattact 104640 ataatgaaac taattaacat atccatcatc ttatattgtt aaccattttt ttgtttttgt 104700 ggcaaaagca gctgaaatcc actcatttag caggaatccc aaatacagtt cagttgtatt 104760 aattgtaatt ctcatgttgt acattcgatc tctagacttg tttatgctac atatgtttga 104820 cttttaaaca ttctactcaa atcaacccta agtcagggtt agcacagaca ggacttgtta 104880 acaaggtaga aggtgccaca ttgtacctgg gtgtttatat ttctctaaat cttgttctga 104940 tcatatttta ataaatataa tcatcaggac accaaaattc attccttagc tattaaaaaa 105000 ttctattcta ttttattgtt aagatttagg agagcatggt acagattctc ttaactatac 105060 ctatcagaag cctatgtttt aagtccaatg tataggcact gctctgtttg tctctggtgg 105120 gaacttaccc tgctttacct aatttcatcc tagcttcctt tttgtgaaag atcacccttg 105180 cttagcctat tttttggcaa atctacacct tggaaatagt agtaaatgac ataagcatat 105240 taatatttat gatgtgattt atttttgttt tcaagtcata tactggggaa gattctcaaa 105300 tattaaaaca atgtatcttt acatttatgt atgtcgttct tgttctgttt tagaaggctt 105360 gtatttgcat ttttaacatt ccaaaaggta aacctgtaat cataatgttt tcatcaattc 105420 aataaaacca ttacgtttgt aatagagagc cctatagttg ccttagttaa gtttgctgca 105480 actcatttta tatattcttt taattttgat ccctggattt ttaattgatt attaaacctt 105540 cattaggata tatatgaaat gtaaaaatat tgagttataa tctaccgttt tctaaaattt 105600 tatactgcat ttttatatag aaattcaaat tgctcataat cattctagtg aatttaagta 105660 gaaaggtatt tattactagg tattaaatgg cttataatat tgttgacaag gttccactgc 105720 aaaatagttc accaagggag ctgtggcctc ttctgtgatc aagaagccat ctgtcaactt 105780 gggaagcttc cactatagca cctaacccca gactacattg agtaggaagc tgtaataatc 105840 aggaagcttc tacctttgca tgctctgcaa accaacgtga acctgctgta atttgtaacc 105900 acaaaatgga tgcctgttga tacttacgaa gctcatcatt gtatgctggg ttctttgcta 105960 atactttctt ataaaaatta aatacctcca caatcatgca tgctagcaga aacagcagag 106020 gagtagcctt agcctcactt cctgcttata cctgtcatgc aaatatacag aacccagaac 106080 cctagctgaa agggagtttg agaactagta tttgtattgt cccagattct gcagtggaag 106140 aattcatagt ggatggaagt tagaatgacc cttgaattac aatcggccac attcatcaca 106200 aatacattaa ataagagtaa tttgccataa agctctatgt ttgtatactt ctttgttttt 106260 tttttttttt tttttttttt tttttgagac agggtctcac tctgttgctc agtctgtagt 106320 gcagtggtgt catcatagct cactgcagtc ttgatctcct gagctcaaac gattctcctg 106380 cctcagctcc tgcttcagcc tcctgagtag cggaacaaca ggtacacacc accacacttt 106440 gctaattttt tattttttat tttttgtaga gatgtgggtc tcactgtgtt gcccaggatg 106500 gtctcgaact cctgggctta agtgatcctc ccaaagtgtt gggattacag gcatgaacca 106560 ctgtgcctgg cccatatact acatatattt aaaagtagta tttaaatgtg taggatgaat 106620 gaaagaggca gtaagagaac aaagtgaatg aaaaagtatt tctatatgaa gtgaaagcag 106680 gagagtcctc tctgttagag aacaacagaa ttgcatatga cagactagct ttcttaatat 106740 ttctagaact tgatggctgt gaagagcgtc ccgtaggaat tctcccttca cttaggaaaa 106800 catacctcaa aaccatcagc tgtttagcat gcacctgctt ttcctggtat atctcagtga 106860 agcagctaaa ttgtaaatga ttaagtaaac tttgcagtgt atcatgtgca aaagcacagt 106920 aaaaacaaaa atgcattgga agctgtgagt tgttgcactg cactcatgga tgaatagctg 106980 ttggttcgca ttgcgttttt ttgttttgtt ttgttttgtt tttttgagat ggagtcttgc 107040 tctgttgccc aggctggagt gcagtggcgt gatctcggct cactgcaagc tctgcctccc 107100 agattcacgc catcctcctg cctcagcctc ccgagcagct gggaccacag gtgcccgcca 107160 caacacctgg ctaatttttt gtatttttag tagagacggg gtttcaccat gttagccatg 107220 atggtctcaa tctcctgacc tcgtgatctg cctgccttgg cctcccaaag tgctaggatt 107280 acaggcatgc cgcattgcgt tttatataat tctcatggtt ctagtctcga gctgtaggat 107340 tttgatcact gtttcaaaca ataatgtgag tttgctaaga ggtctaaata acaaaagcta 107400 agtgttccaa acacatatcc aaacctatac actgggcaat gcatctgaat tatatgtgaa 107460 atttcctgcc attatttaag acacaaaagg aacattattt tgataatgta tttatttgtg 107520 agtggagtgt tcagaatgag cacgatgggt ataacatttt tgtaggtttt taaagttgaa 107580 atttagtgta aatccaaaga atcaatagac aagtctgtgt tttacttaac ctatatgttt 107640 aaattagcat ttttagatac tgattttatt cctaatttca gaattctcag cgtcttgccg 107700 atcaatatcg caggcacagt ttatttggca ctggcaagga tcaaacagag agttggtgga 107760 aggctttttc ccgtcagctg atcactgagg gattcttggt agaagtttct cggtataaca 107820 aatttatgaa gatttgcgcc cttacgaaaa aggtaaacgg tgtaggagtc tgcctgtttg 107880 acttaatttt gtttcccact ccacattaaa agatcctttt tgcttttaat agggtagaaa 107940 ttggcttcat aaagctaata cagaatctca gagcctcatc cttcaagcta atgaagaatt 108000 gtgtccaaag aagttgcttc tgcctagctt catttttcag tttttttctt gtaacttctg 108060 cattttttgt tgctatttat gtgattcaaa ttataccagt ttataggcct ctcacaagta 108120 aaatgaatta cctgtttgtt tttgtatgcc tattttagtc agtttggggg aagggatctg 108180 tgaggaaagg ataagtcata gagcactttt cttttttaag agacagagtc tctctgtgtt 108240 gctcaagctg gagtgcagtg gtgcgatcat agcttactgc agcctcgatc tcgtgggccc 108300 aagtaatcct cagccacctg agtagatggg actacagaca tgcactacta tgcccagcta 108360 atatatttta attttttgta tagagacagg gtcttctagt gcttcctagg ctggtcttga 108420 actcctgagc tcaagtgatc ctcctgcctc agcctcccaa actactggga ttacaggcat 108480 gatccaccgc tcccagccag aacattttct tggttgatgg gaagtagctg accatggtat 108540 ttagaaaact tctttctcat cgattaaaga agcagtactg aaatcaatgc ggaggaatcc 108600 atatatcata tttacttctg gtgtgtagaa gtggaaaggg aatacatttg ttgcttactt 108660 ttttgtacct ttacatgtga ttgatcactt gtgagttttt tctttcaaac atcttaaagc 108720 ttccagagct ttttctagaa aaaaaaatca gttttaagaa tcaccagttc taaaagggta 108780 atatcttatt catctttctg agaatggagt atcatgattc atgaattaga tacttgcatc 108840 ttaacatttg aaataattta attttattat tttttagttc gaaaactgta tcttcgggca 108900 ccaaagagca ttgttataat caagtaccag ttgaattaag tacagagaag aaggtttgtt 108960 ttaaagaaat tgttctgatt tatttcattc tttattgatt caaattctgt ttaaaatttt 109020 atattttaat tcctttccaa ttaaagagaa aatggcatat ataacaaagc ataaaattcg 109080 gccagggaag tgatgtgaac agactaaaat ttattgtata taatttctgg ggctaataaa 109140 gaattggagg tatttgagaa aggaattaat ttgggttctt ttaaacctat ctgctaactc 109200 atttggctta gagtagtcac atgttataat acttatagtt gatcaaaaaa ttgattccta 109260 agtgttctta ttaaagacac acacacacac acacacacac acacacattc tctctctctc 109320 tctctcacac acacacacat gcacacacac ttatgtactt tcttgctttt tttgacctaa 109380 gatcttagat aactattaca gattaaatac taatccactg gcagacttca gctaattaga 109440 acactggaat aataggcaag catagtgaat tacattttct ggtgaacttt ttctgcttta 109500 ttgaagtatg cagaatgtaa atgaattgtt tttataactt tggcacttgc tgtatcttag 109560 aacattcttt tgatgattta ttttctgtag ttttgggaga gataagacat tggaatgcgt 109620 ttctaactac ctttagaact ttagaaactg ataatttagg aggttatttt caggtgatta 109680 atttgacagc ttgattaggc aaagaaaaaa ttgtgatttt gagatttttg tttcttattt 109740 tcttcacatt taaaagtttt ttgaaacttt ttttaatgga cctttatatg tttaaatgca 109800 gtctaacttg gagaagttat attcttataa accatgtgat aagatttctt ctgggagtaa 109860 catttctaaa aaaaggtaca gagttccata tttctatgtt ctatacttgc tttatgagta 109920 cttttttttc taaagagaaa gaactgtcag atgttgggct atttcattgg caaaaggaag 109980 ttaaatttaa aacataagct tttcagtatt agaatgatca aagtgagcta taaaagaata 110040 atgttaattt aatagctaac acttcttgga tattactgtt tgtcaggcat tatgttaaat 110100 gctaagaact ttatatgtga tatctcattt aattcttaca agagtctaac agctgttact 110160 atttatcgcc attttatagt tgaagatacc aagggttaag aagttgacaa acttgttcaa 110220 gagcatacag ctaatggccg agctggcttt caagtctata tttgtctacc tctagcatca 110280 agacactatt tatttttctt tgtatgaaat atatacaggc atactttgtt ttattgtgcc 110340 tggctttatt gtgacttgca gatattgcat ttcttataaa ttgaaggttt gtggcaaccc 110400 tgcgtcaaac aggtcatatt agccccattt tccaatagca tgttctgttg tcatgtcttt 110460 gtgttatatt ttggtagttc ttgactggcc attcaccatt tctctccctc tcctcgggtc 110520 tccctgttcc ctgagataca acaaaattga aattaggcca attaataact ctataatagt 110580 ctctaagtgt gttttttttt ttttcgagac tgagtctcac tctgttgttc aggctggagt 110640 gcagtagcac aatctcggct cactgcaatc ttcgcctccc gggttcaagc gattctcctg 110700 tcttagcctc ctgagtagct gggactacag gcgccccccg atcatgtctg gctaattttt 110760 gtatttttag tagagatggg tttttgccgt gttggtcagg tggatcttga actcctgaac 110820 tcaggtgatc cgcctgcctt ggcctcccaa agtgctggga ttacaggtgt gagccgctgt 110880 gcctggccca tctctaagtg tttaagagaa aggaagattc acatgtctct caatttaaat 110940 caaaagctaa aagtgattag gcttagtgag gaagccatgt cgaaagctga gataggccaa 111000 aagctaggcc ccttgcacca aacagttagt ttgcaaaggc aaaagttcct gaaggaaatt 111060 aaaaatgcta ccccagtgaa taaaacaatg ataagaaagc aaagcaggct ttttgctgat 111120 atggagaaag ttttagtggt ctttatagga gattaaacca gccacaacat tcccttgagc 111180 caaagcctaa tccagagcaa agccctaact ctcttcaatt ctctgaaagc tgagagaggt 111240 gaggaagctg cagaataaaa gtttgaggcc agcagaggtt ggttcatgag gtttaaggaa 111300 agaagccatc tccataacat aaaagtgcaa agtgaaacag caagtgctgg tatagaagct 111360 gtagcaagtt atccagaaga tctagctaag atcatcgatg aaggtgcctg cactaacaga 111420 ctttgaatgt agaccaaatg ctttctacca gaagaagaag ctgtctagta ctttcatagc 111480 tagagagaag tcaatgcctg gcttcaaagc ttcaaaggac aagctgactc tcttgttaga 111540 agctgatgca gctggtgact ttaagttgaa gccagtgctc aattagcatt ctgaaaatcc 111600 tagggccctt aagaattatg ctatatctac tctgcctttg ctacatacat gtaacaacaa 111660 agtcttgatg atacctgttt acagcatggt ttcctgaata ctttaagccc attgttgaaa 111720 cctgcttaga caaaagattc ctttcaaaat gttattgctc attgacaaca cttagtcacc 111780 aagagccgta atggagacat acaaggagac taacgttgtt ttcatgcctg ctcgcttaac 111840 atccattctg tagctcatgg atcaagaagt aaattaacct tttaagtatt attatttaag 111900 aaatacagtt tgtaatgctt tagcttctgt agatagtgat tatcagagat gggtttttaa 111960 gaggttttcc agaaaacctt ctggaaaata ttcactattc tagaagtcat gaagaatatt 112020 tgtgattcag gagagtaggt cagaatatca atattaatag gaatttggaa gaagtcgatt 112080 cttattaaaa tcaagagttt agtgatagac atactgagtt tgggatacct gtggagtagt 112140 ccagaagtta atttaaatat atgggcttag tgtacagaag tgagcagggt gcttatatat 112200 gaataaatat tattttaaga tatatttaaa ttttccttaa aataatacct atacttgata 112260 taaaaagtta attggaaatt agtggcttat gacaagcata ccagcccaca ctcttcccaa 112320 acccactttg ctcttattca tagaagctgt catcttcaaa tcttccagct gatttccctg 112380 gcgtgtgcct tcttatttct gaatgacacg cttagagtac tatttttttg acttagcaat 112440 tttagaaatt ttctactcat ctcctattat ggtagatttc ccctccttca ttcctcctcc 112500 aatataatta tatttcgtca tattaataat ttgtttatat atatttttaa tataatatga 112560 taatattgta tttatattat taaaactaca caaatattat atacacacta ctaacccaac 112620 cgtgttatta tggccaccac tacctttatt tttttccttg tgttagtgat tgtctttgtt 112680 ttattttctt ggttttgagt attcctttta ctaattttct tttttcctat ttcaatctct 112740 cattatttgt ttactcattt ggagtgttcc ttgactttta tcccctctta cctagtgaca 112800 ttttaatttt agttatcaaa tttttaattt ctaagaatgc ttcttgttct cttcttgttt 112860 cttcttcccc accagccaaa aatctatgat gttatagcaa ggatcataca ttgtttccca 112920 gtaggttaag aaaccttggt taaaacctgt tgtatcccag taagttaaaa gacgttaacg 112980 tgtcatcttc agtatggatg aaagaatatt ttctttcaaa agcagttggt tgaggaagag 113040 aatgggacaa atgctctttt taaaacacca attttgtgat gaactcaaat tgcaatttta 113100 actttaccat tataatgaat gtatttgatc caaaatgttt aaaatctagg ctgttgtcat 113160 ttaaataaca aattacctta ctggtatcat gaagaataaa tgtttgtact gatttggaaa 113220 gacattctca tttaggggat gaaatagaaa gtcaatgagg agaaagaaaa gcttttatta 113280 tttattttct tttaaatatt ttagtatcat ggtacagtca ccagaaaaag cttacagttc 113340 ctcacagcct gttatttcgg cacaagagca ggagactcag gtaaggcttt tgtaaaaagg 113400 taattagttt atgataggat agttatgatt ctatgtatgc ttaaaattct gtattttgcc 113460 agcattttaa aaattgttct taagctaaga gtctgagttt atatttcagt ttatattcat 113520 tctaaggaaa aatgtggtat ctgaagctct aaaaataaag gactagatct tttaagtaca 113580 ctttaaaaag tgttgtttct ttgttttttg ttcagattgt gttatatggc aaattggtag 113640 aagctaggca gaaacatgcc aataaaatgg atgttccccc agctattctg gcaacaaaca 113700 agatactggt ggatatggcc aaaatgaggt aaactatctt ttgcatgtgt tctatttatt 113760 tccttctaac aaaatagatt tggaaaatat atctaagttg ataatatgac catagcttcc 113820 actgtcacat ctgggaggtg actcagattc cccctgctgc gatgcttatc tctttgccaa 113880 gctttagtac cgtgtttctg tatgaataaa aaccagttac gttttcagca atcatattca 113940 atatttataa aatctaactc attatttacc caccctgcat tttatccaaa tgccgaaact 114000 cctctttttg gattctttat ttttgattat cttaccatca catttgtagt cagaggttcc 114060 taatgcttaa aacctctgat ctgaattttc tctcctccaa tataaaaccc cttcgtcttc 114120 ctcttcttct tcttcatttt tttttttttt tttgtctgaa gacttgtctc actgtgttgc 114180 ccaggctgga gtgtagtggt gcgatcactg ctcactgcag ccttgacccc ctggactcaa 114240 gctatcctcg cacctcagcc tcccgagtag ctgggactac agaacatgcc accatgctca 114300 gctaattttt gtattttttg tagagacagg gttttgccat attgcctagg ctggtcttga 114360 actcctaagc tcaagcaatc ttcccgcctc agtctccaaa gttctggcac tacaggtgtg 114420 agccactgtg cctggcctct ttttctcatt taaatacttt tcataccttt tgtaaaacgg 114480 gttccttgtt gcctgtctat gccttcctcc tccttcttaa tgacaccacg ttaattctga 114540 ctgttttccc ttggcctgtt gcagaagcct cttaactatt aacccttcat tctctctctc 114600 tgtttcatct gatatatgag taccaaacta aatcttcctt tatcatatct tacttctgct 114660 taaatgtttt ttttctagct tagaattcaa ggccctctat ttatgaactt aaacttactt 114720 ttccctctaa gttacagaat ttgaaatggt ttatcttacc tggattgttt atcacttgtt 114780 gaagatccat tttcaacttc catatattta tttacagtgt tgcttctcct tgtagtttcc 114840 ttgattcctc aaaactcctt ttaagaattc ttgaagatct cgctttatta ctatttctcg 114900 ctttattact gtaaagacta tgagaaggtc tttcatgatc ttatcagcaa agtaattcct 114960 ctctcttgaa ttcatagagg actttcagat gaattctaaa gatgcttctg tagcacttac 115020 cacacaatgc tatattttat ttttttgtaa ttagtggtaa acaagtatta ttatatcttc 115080 tagattttaa actccaaata aagatactag ctccttacct ttttgtgtgt ctcctgtagc 115140 acctagcaca atgcctcata aacaggaggt gatcattaaa tatttagaag aaattatttc 115200 ccaagaatag ttgcttggta attgtatttg tcttttactt ccttttaaaa aattgtttct 115260 gtcactaaat tgcatccaat agatgttact tgagtgcaga attttctaat gacattacac 115320 agtgctacat ctgacactaa ttcttttgtt aaaaaataaa tattctggcc gggcgctgtg 115380 gctcacgctt gtaaatccca ggactttggg aggccgaggc gggcggatca cgaggttagg 115440 agatcgaggc catcctggct aacacggtga aaccccgttt ctactaaaaa tacaaaaaat 115500 tagccgggcg tggtggcggg tgcctgtagt cccagttact ctggcggctg aggcaggaga 115560 atggcgtgaa cccgggaggc ggagcttgca gtgagcggag atcgcgccac tgcactccag 115620 cctgggtgac agagcgagac tccgtctaaa aaaaaaataa aaaataaaaa taaataaata 115680 ttctaagacc atactttaat agaggtgttt tttttttttt tttttttttt tttttttttt 115740 tttggtgata gagtctcact ctgtcaccta ggctagagtg cagtggcgcg atctcggctc 115800 actgcaacct ccgcctcctg ggttcaagca attctcctgc ctcagcctcc ggaatagctg 115860 ggactacagg tgcgcgctgc cacccccggc taattttttg tattttagta gagatgaggt 115920 ttcactgtgt tgtccaggct ggtgttgaac tcctgagctc aggcaatcca cccgccccgg 115980 cctcccaaat tgttgggatt acaggcgtga gccacagtgc ctggcccaga ggagatattt 116040 aatgaaaaat aataatcatt agataggcag atttttagaa ggagggcatc gaatgggttc 116100 ttggatattg gacacaataa gaaatattga gctaaaagtc tgaaggaatt ggcagatata 116160 ctgttacagg taaacacttt gtagaagaaa ataatgaatg agactttctt ttgagatttt 116220 cttagcctct tagttgttcc cagttaaagc ctcatatttt tccttttcat gacaataaaa 116280 ataataataa aatcagtaat aaagtgaata tatgagatgt taacctgttc ctttatgaca 116340 atgtcctgtt taccaattaa cagtgtgttt ttgtggtgat gggggcaaga caaatcttta 116400 aatggtggaa agcaaagaaa gaaattataa aacatgatta gttgtattat acgttgtttt 116460 tggttgttgg aaaaactata catttattga gagaatcatt aggaagctga acatcagcta 116520 tattgctgga gtgatactgt ttcagtggtt tcttgacctt tttgttgttg ttgttgttgt 116580 tgttaaacac agaccaacta cggttgaaaa cgtaaaaagg attgatggtg tttctgaagg 116640 caaagctgcc atgttggccc ctctgttgga agtcatcaaa catttctgcc aaacaaatag 116700 tgttcaggta aaatactgtg gtttgcagga gctcttagag aataagcatt ttttgtaacc 116760 atttcaaaag taccctccag aagcaacatt tgctcacttt atttgcattt ccatactgga 116820 cacttagaaa atgaattaaa attgttttta cagtcaatct gttgtaaaaa catgtcagtt 116880 atctactttt aaagatgata ctaaaaagta gttgtccagg ctgctgatgt ctttctattt 116940 cattgggagg ttttgttttt aaattggaaa cattatttta ggttgataaa ttataatttt 117000 acattcaaat gtggtagttg gaatttaaag ctggaaagtt atccttgcta tgagttggtc 117060 aggagctcag ccactttctt ttggtttagc atcttctcta atctccctcc ccttccagta 117120 atgctgtctt ttgatagtaa gtggatttca tattattctc ttcagtttta atagtgtttc 117180 cttcatatcc ttttattatt gcttgttctg ccctaagtga ccatttccag aaatgtcatt 117240 taggattttc tctaaactcc acgtagcaga ctctataatg catactctgc agaaggtgag 117300 gcagtgggag gtagagggga gactactaga ctaggagtca cggaatcagg actttagttc 117360 ttccttacag ttgttcacct ggtgaacctg cacatgtcct ttaatttcct tgggtctcca 117420 tttcctcagc tatacaatgg aaatgacact tcctccccca catccaggaa acaacagatg 117480 acattagaaa atagaagaca tgggataagt ataaaatgtt gaaagagtta aacacattca 117540 aggcaatatt aagggattat tttttacttc caagaagctc ctggaagctt tgggcaggca 117600 cagttggatc ctactttaga aaaatctttc tctaactata agtagaaaac ccttctgctt 117660 tttgaatgta gcatttccct cttttgatat agagtatctt tggcaacttt gaattttctt 117720 tttcatactc ttatataaga catcatgtga aaattcttat ttcttactga gtttttggaa 117780 atgaaattat aatgtcttaa tagtttgaga aagaatatca tacctaccag cggtaattga 117840 gtaagttccc tctctttgga cacttgaaag tagtatcttc tttcatgaat tagtgatatt 117900 atttaataat gaatgagtga tctctcctaa ctccccttca gaagaggaaa atgaagtagg 117960 ggaaaaggta aattccccaa gggataggta tgaaaccttt atgaaccttc tggatagaga 118020 agatgactgc tgatttctgt gattagaaat tatacttggg ttattctgca aattgaaatg 118080 aattatttaa aaaaaaacaa ctttaatgtt tattaagcaa gttttgttat tcatgagttt 118140 cattagcctt ttattttttt tttaaatttt gaagtaaaat ttcttgctgt cacaatacac 118200 attaaaaatt acaaatatga cacatattaa acacattaag atggccgaat aggaaaaata 118260 tgctaaaata tttttatata aatacatttt ttgagaattt tgagaatttc tggaacaaag 118320 taatgatata atccataaat gtacaattaa agagtttaag gatatccaaa atacttggca 118380 aagtaatctg aaataatact cttaggaagg tagggcaaga atgtgattct agtaagcaaa 118440 aatgtgatca aatcgtattc tagtcccagc tactcgggag gctgaggcag gagaatggcg 118500 tgaacctggg aggcggagct tggagtaagc cgagatcgtg ccactgcact ccagcctggg 118560 cgacagagcg agactccatc tcaaaaaaaa aaaaagacta tatgaacatg tatggcataa 118620 atatgtacaa atattattta ttttaaaaaa attcaggggt agggacaggg tagttagaaa 118680 atatctaagg atgttcatga aataatactg gctatgaatg acagttgatg aaaccgggtg 118740 gtgcccatct tattccctcg actcgtgtat atgtttgata tatcccacaa taaaccttaa 118800 aaaaaaaaag atgagtggtc aattatagga agatataaat agaaaaggca ataaggacaa 118860 aagttggcaa agcttaccta agcactcttc agataaaaag acatttttgc taactagatt 118920 tgaatattat agtttaattg tcaaggaaaa tgcctcaact taatctttgt taagagacta 118980 cttaaggcac tatcagaagt tccctcatgg caaggtgcaa tccctcatgc ctgtaatccc 119040 agcactttgg gaggccaagg caggcaggtt acctgaggcc aggagttaga aaacaacctg 119100 ggaaacatag tgagacccga cctctacaaa aacaatttct taaaattagc caggcatggt 119160 ggtgctagcc tgtaatccca gctatttagg atgcttaggc aggaggattg cttgagcccg 119220 gggatttgag gctgcagtga gccatcattg tgccacaata ctccagcctg agtgatagaa 119280 aaaaaaaaaa aaagtgtctt tgttatattc caaacttgtt ctcaactttc aggtgagctg 119340 gcttcctgta taactcttgt ataggacaga acatactggt tggggcaagt gaaactgtct 119400 agttgtatgc ctcataaatt aatgaatttc ctttctaata tatacactga tatttataca 119460 cacatacaca taaaaccaag ctcaatagat gggtagtgca gctctattcc ccaaaaccca 119520 actaccctgt aacaagacac attagacttt tgagattgca aggatgagga ctgaaatgct 119580 ggcctagacc atggtgttgc catagtgggg tgaccagtct gaatagccaa caatgcttcc 119640 tcagtaaata cccattttgt cttggtggga tttctataaa ttgcaaaatg cagctattat 119700 gaagctgtaa aagagaaaca gaaacatgta acacctggga ctgttttatt aggcccaccg 119760 tatgctcaga acatgaaatc tccactgcta gggttatttg attgaaatta tcttttgtgt 119820 tgatgtgaga gtttagctct gagattcttc cacatgtaaa atgtaatccc ccaaagtatt 119880 tggcaagcac attttattgc cttgggtcag ataattgaaa cattaggcat catatatata 119940 gcatgtaaaa agtaaaacag aaacatttat gtttctcacc aagcagtaaa ttagtactca 120000 actaataaat ttcttaaact ccctaataac agaatatgga aacaaaaaat aaatctttcc 120060 aaaagaagag ctcatggaca catttcctca tatatgtata cataatatag tagaacacat 120120 gataaataac ctataaaaat gataccaata tcattcatca agagacgagg ctcttcttta 120180 aattattaat ttcatctgtt acaggtttta ttatgactgt agtatgctgt tttcatctac 120240 cttttatgtg tagttaaaaa aatagttttc tatctcttta cctttatttc agcctttaaa 120300 aagattccat tattttttca ttaatcttgt ttttcagttt ttcccatttt ttcttttaaa 120360 catttcttaa ggaaccatat ttaagatttt atagaatact tagatttcta gttgggatgt 120420 atcatttaaa attagatatg tagagagagt gttatgatat atttccttac gatatattag 120480 tggttatagt acctaaattt gaatagtgat tctgttcatt cattcattca ttcattcaat 120540 attcacttcc aggagattgg ggacttattt aaagacagag tagttcacat tatagttcct 120600 ttttttagtc cttcttattc gttaaagaaa agactaggaa atgtttgtta ttacaaatat 120660 tttattaaaa ttttgtgtgc tctagcatta ttttaccttt taaaatcaat atgttaaaaa 120720 tccaacttct ttttgagctc cccataaaaa gggaattatt tgttgcttat gggtttaact 120780 tgtgttattt ttttcttaat ggctaattat catacatata ttctattatt gtattgatat 120840 tactgatcat ttgtgctaca ttaaaaattc tgtagacaga cctcttttca agtacaaaac 120900 ctcaagaaga acagaagacg agtctggtag caaaaaataa aatatgcaca ctttcacagt 120960 ctatggccat cacatactct ttattccaag aaaagaagat gcctttggta agtgtgactt 121020 tcatgttaca gggaattttt ttagtttact taaacttgtg ttttatcagc tttttagtat 121080 taaagttctg acttgggatc aatttcctcc aaccctacaa taaatctcag tttatcttta 121140 attttaaaag agaatgttgt tttctttttc tgttaagcct ccctgttaag taatagcagc 121200 aagtttagtt tggccatgaa tatcttctag agattgtatc ggggtactga taaacacatt 121260 tgtagctcag ggatactgca tcagccatat tttaaaatgg gactaacagt ttaaaaacta 121320 taaatattca cagtgttaag aaacaatctc aagatgcatt aagaaaaagg aaggtgcaaa 121380 acagaaaaac aaacgtaaac gtgtgtgcat atgcatgctt atatagtcac atattcttgt 121440 atgtgtacaa aaaatacaca ctggatctct gcaagcatag ccaagcaact ggaaatatgt 121500 ttttaaaaac ttgcttttca ttctatctct tctagtactg ttttgatgct ctttgaaaac 121560 aatctaattg ctgtaacaaa tgaccatacg taggccgggt gtggtggctc atgcctgtaa 121620 tcccagcact tcgggaggct gaggcaggca gatcatttga ggccagggat ttgagaccag 121680 ttggacaaca tagggagacc ctgtctttac taaaaataca aaaattagct gggcgtagtg 121740 acgcatgcct gtaatcccag atacttggga ggcggagaca tgggacttgc atgaacccag 121800 gaggcagagg ttgcagtgag ctgagattgc gacactgcat tccaacctgg gcgaccgagc 121860 aagactcggt ctccaaaaaa aaaaaaaaaa aagaccatat gtaatgtttc ttcattgttc 121920 taagataaat ctttaaggct gttgaggttt tttgtataca aaatggagag taagttttaa 121980 tgggatggga caaaatgagg cttacagttg agtttaattt gagttcacat cctgttgaca 122040 ttaagttgat ttggaacaag tgatatggtc caatgcctgc ttttctattg tctgtggttc 122100 catccactag tgcctgtgtt acacacctct tgttcaggtt ttatcattta aaataaataa 122160 gaataaacag tccatagctt atcttactta ctgaataaat gctctaattt gacagtcatg 122220 tttcttaaag ttccttacaa aggccattgc ccaagaaacc aaataattcc attatactat 122280 ttttgaaata gaacacataa taaatgggaa ttttaagttc agtttcttat gtaaacaata 122340 acttctatgt acatgttaaa tatgcctgta tatacctaat ttgaccatgt atgtatagta 122400 gaaatgaaaa cagttactaa gaaaatttgt tattggctcc aaattttctg aattaagtgt 122460 attctaatgc tcagccataa tatggggttt catgtgttag tttatgtatt catggttaaa 122520 aatgtgaaga ctgttatatc ttcatttgtg tcttttggta ttatttggtt gtattttatt 122580 gtgtgatatg gtggtataat tatccttacc tcccaggagt ttgagagggt cttgccagtt 122640 aaccgcagaa ttaaacatgc ttaggactaa ttaatcagga gcaatactac aattagttgg 122700 aggtaatttg aaacctggtt tcaaataacc ctgatattat gcacacatgg tgcacacttt 122760 tctagtagac atttaatgaa agtaatttaa aacctacctt tgaaggatga aaaacattgc 122820 cttaaatgct ctattctgtg aaagtatcaa catttatgca aatacagtct aaattcagac 122880 tttgaaaatg tattgaaaga gaggatcatg aaataagtta gagctgagtg acaaagcttt 122940 ctgagtgttt aaaagaatgt tttacctaat aaatatctga aatgtatttg gagccacatt 123000 tgtttaaaga actgtataaa tatgtagcac tgttcatgtg aagttcaata gtaggaaaat 123060 gctgacagcc cttgtggaac tgtggttatt attattttat gaatagagcc aatttcaaac 123120 acctattaga gtcttctcag gaacatttta tagaatgcat ctggagcctt atgttatctc 123180 taagcatttt aggatttgtc ttcttggaaa ttcatgtaac caaaccacca tgtgttattt 123240 caagtgtata tagtattggg ttacagttta ctatgttttc agaaggttgt gacaactatt 123300 agacttacag agaatgactt ctctgccact aacggctttc taaagtgaat agagaggggc 123360 gaggattgaa ttcttcggta aagctgggtg attttgtttt attcaataca gtataataag 123420 tataaaaagt agaacctata gagagctata atgggggtag ttttaaagaa attctgaaaa 123480 tgaaaaactt aagtaaaggt ttagttcatt gtttatttca cactgagcat ttactacctg 123540 aatgttttgg acattttatt tccatgactg gagtggacac ttttacaact cactgggttc 123600 tttgctgatc tttctctaga agagcatagc tgagagcagg attctgcctc tcatgacaat 123660 tggcatgcac ttatcccaag cggtgaaagc tggctgcccc cttgatttgg agcgagcagg 123720 cctgactcca gaggttcaga agattattgc tgatgttatc cgaaaccctc ccgtcaactc 123780 aggtgagagg catggcctag ctctgcaccc ttaatgactt gatgaagtaa acaagcaatc 123840 cactatattt ttcactgtta acagcattaa tcctttatgc tattatgaaa accttacttt 123900 tgtgattctt tttcttgttt taggaaaaca atctttcttc ccattatcac tcagaggaaa 123960 gtatactgag aaattttttt gttttgtttt gttttttgag acagagtctt gctctcttgt 124020 ctaggctgga gtgcagtggc gtgatcttgg ctcgctgcaa cctctatctc ccaggttcaa 124080 gtgattctct tgcctcagct tcctgagtag ctgggactac aggcgtgtgc caccatgccc 124140 agctattttt tgtatttttt gatagagaca gggttttcca tgttggctag gcaggtctcg 124200 aactcctgac ctctgatgat ccgcccacct cagcctccca aagtgctgcg attacaggtg 124260 tgagccatgg cacctggcca atacactgag aaatttttat tttccttttc agcttaaggt 124320 tacaacttcc ccaccatcca aaacgtgcac tttcattttt tttctaattt ctatctcatc 124380 acttgcaaaa accatatttt tctccacatt cattcccagt agcttcctga ctcctagttc 124440 ttccctaaat ccttctgagt ccttgtcatt ggtttcgctt gagtagcctt tctaatcaac 124500 acagtcattg gtatcagtta ctgtgacatg gaagggacag accaagttct gtgggccgct 124560 acgtagaagg atttcctgtc actttgctgc agaacctcag ctcgcggaga gcaagcccct 124620 ttgcttgccc tgtagaaata ttttaaatta ttatcctttt tttttttaac agaagtaaat 124680 aggagatacg ttagaggatt ttctctccta gatgtgtaaa tacaaacttg gggtcttata 124740 actcaataaa tctgataaat ttcttttgac tgttaggata gagcagtggc cataccaata 124800 gcctcatctc caaagctgca gtgaagatac tttttactac cttaaagtct ttcccatttg 124860 tgaacaactt gtgaacaatt ccccccaaga atttggaaga tcactctctg aaagcacagt 124920 caatactgta cttaaatgga tctgagcaaa aataagtcac ttagaagaca ggattatttc 124980 tagacttgag tgtgacttga ctgaaggtct aaagaacaaa cagctccttc acttccattg 125040 atcacggtgg aagcacaggg aaaggacaga cacggaggca agttggagta gtgctcatct 125100 aagttccagg gatgcggggg agtggccagg ggacttcagg tatagtaaat aaataaccta 125160 tttataagtt atgtcaatgt catgtttgaa atagaaaacc aaatactgca tgttcttact 125220 tacaagcagg agctaaagtt ggtgcatatg gatataaaaa tgagaacagg ccgggcgtgg 125280 tggcttgtgt ctgtaatccc agcactttgg gagacctaga tggaaggatt gcttgagctc 125340 aggagttcaa gaccagcctg agcaacatag tgtgaccccc atctctacaa aaaataagaa 125400 aattagccag acgtggtggc atatacctat agtctcagct acttgggagt ctgagtcagg 125460 aggagtgctt gagctcagga gtttggggtt ataataagct gtgatcatgc cactgtgctc 125520 cagcctgagt gacacccaga gtgagaacct gtctcaaaag gagaaaaaaa aaaaagtaac 125580 agtagacgct ggggactact gaggggaggg aaggaacaat ggttgaaaag gtgggaaggg 125640 acagtggttg aaaaactacg tgttgggtac tatgctcact atctgggtga tgggatcaat 125700 tgtacctcaa acctcagcat cctgcaatat actaatgtta caaacctgcc catgtactac 125760 ctgaatctaa agtaaaagtt ataatttaaa aaaattataa taaaatcaga aaataaaggt 125820 ctgagatgga aaattaaaag accaaagcca cccataagca caataaatcc ctccccccaa 125880 aaaattatat ctattaaaaa aaggtgttgc gccaggcact gtggctcatg cctataatcc 125940 tagcactttg ggaggccaag acgggcagat gacttgactt gaggtcagga gttcaagacc 126000 agcctggcca acatggtgaa accctgtctc tactgaaaat acaaaaatta gccagcagtg 126060 gtggcatgcg cctgtaatcc cagctactca ggagactgag gcaggagaat cgcttgaact 126120 ggggaggcgg aggttgcagt gagccgagat catgccactg cacttcagcc tgggtgacag 126180 agtgagactc tgtctcaaaa aaaaaaaaaa aaaaagacct tgtaccctga caagttttag 126240 tttgtgcagg aatgctagaa tgactcaaga ttggaaaaat ctttaaatgt taattacaca 126300 ataagggtaa aaggagaaaa attacctaat gtcatctgag caacaagaag aagaaatgaa 126360 aggcattaaa aattgggaaa aatttatatt tgacagtatc ttaacaacga attctgcttc 126420 tatatcactt cctagctttc tgatgataac ttcccgtgca gatctgtatg taaggaatgg 126480 acgtagtagt catgctaatc tgagtattta tctgtgtgat acttacgaat taacgatgta 126540 agttaataag ttagcatttc gtgaacctgg ttaataccat ttgctaaggt taaattagcc 126600 aaatcctgaa gtaagctgta aaacatccaa ggtagggtag agaggcatct tatgagaaag 126660 ctggccaact ctcctggtca ccttctaatc ttcctaactt cagaaatcaa ggcagagaga 126720 ggaaaatagt aattactttg taggattaga tttatggttg tcgaaacctt tgtttctcca 126780 gtgcagaatg agatagcgtt ttagggaaag ccaaagactc agatgtcttc ttcatgctca 126840 tcgtgtggaa tttttcttcc tttagaaatg tattgtctct cagggcttaa agcaatttgc 126900 atctttcgat gagacattga gtaataggca atattctctg aaataatttg tgcaggctgg 126960 gcacagtggc tcacacctgt aatcccagca ctttgggagg ccgaggcggg caggtcactg 127020 aggtcaggtg ttggagacga gcctgaccaa catggtgaaa ccccgtctct actaaaaata 127080 ccaaaattag ctgggcttgg tggcacacac ctgtaatccc agctacttgg gaggctgagg 127140 caggagaatt gcttgaaccc ccatgggagg tggaggttgt ggtgagccaa gattgtgtca 127200 ttgtactaca gtctggacaa cagagtgaga ctctgtctca aaaaaaaaaa aatagaattt 127260 gtgcagttcc ccccaccccc tttttttttt ctgttggcat ttttgctatc atttagctgc 127320 cttctttata tcctgaaact tacaggtggt gttggtctag tcagtaagag caaaggcttt 127380 gggaatagat agatctgtat ttagaccttg gctctagcat ctcattgtta tgtgacctcc 127440 atcaagtgac ctaatttccc taatattcaa tttcctcatc tctaagacag ggagttaata 127500 ttgcctctct tatagaattg tgagaaatat agtcatgtgt cgcttgatga tggggatgaa 127560 ttctgagaaa tgtgttgttg ggcgatttca ttttgtggga acctcacagg gtggacttaa 127620 acaaacctag atggtatggc ctactacaca cctaggctgt acggtatagc tcctgtcttc 127680 aaacctgtac agcatgtgac tttactgaac actgtaggca attataacac agtggtattt 127740 gtatatataa acatagtgaa acatagaaaa ggcccagtag aaatacagtg taaaagattt 127800 tttaaaaaag ctgggcatgg tggctcacgc ctgtaatccc agcactttgg gaggccgagg 127860 caggcagatc acttgaggtc aggagttcaa gaccagcctg gccaacatga tgaaactccg 127920 tttctactaa aagtacaaaa attagctggg cgtggtgttg ggtgcctgta atcccagcta 127980 ctcaggaggc tgaggcagga gaattgcttg aacccaggag gtggaggttg cagtgagtca 128040 agattgtgcc actgcacttc agcctgggag acagagcgag actctgtctc aaaaaaaaaa 128100 aaaaaaaaga gataaaaagg tacatctgta cagggcactt accacgaatg gagcttgcac 128160 cctgggagtt gctctgggta agtcagtgag tgagcggtga gtgaatgtga agacctagga 128220 ctgtgcactg ctgtagactt tataaaccct gtgcacttag gccacactca cccctgtgat 128280 acgagtctac ctactgtata acgtacctgc atatgtaccc ttgaaactaa aacaaaagtt 128340 aaaaaattta tcttcttttg ccaataataa attaacctta gcttactgta atgattcttc 128400 tttatgaatt aaaatctttt tactcttttg taataacact tggcttaaaa cacaaacata 128460 ttgtacagct atacaaatat attttcttta tatccttctt ctctaagatt ttttctgttt 128520 ttgattttgt taaatttgtt tttacttttt acattttttt tgttaaaaac caagacaaaa 128580 acccacacat cagcctaggc ctacatgggc tcaggatcat cagtctcact atcttccacc 128640 tccacatctt gtcccaccag gtcttcaggg gcagtcatat gcatggggct gtcatctcct 128700 gtgataacaa tgccttcttc tggacacctc cagaagggcc tgcgtgtttt acagtgaact 128760 tctaaaaaat aataaaatgt atagtatagc aaacacataa acatagtaac atagtcattt 128820 attatcattt tcaagtatta tatactgtac ataattgtac atgctagact tttacacagc 128880 tggcagcaag gtgagtttgt ttacaccatt accaccacaa acacatgggt gatgctttgc 128940 attgtgatgt tacgatggca tgatgtcact aggtggtagg aacttttcag ctccatgata 129000 atctaatgga tacttgttcc tgttggctgc ccgtcgttga ctgcaacatc attatgtggt 129060 gcatgactgt aaattagata ctgttcagaa agctttggca cactggtaat agcaaatggt 129120 ggtggcaaat atgatgatga tgatgatgat gattgaagac atagatggta aaattttatg 129180 gtgtcttaaa agtaccctct aaatatgatt atttttatag tctgtccttt tgaataggca 129240 cttaagaatg tatgaactta ataagtatat aagaaagaat gttccccaaa atatatctta 129300 cagaggcata caatttaaga attcaaacag gttgtaatgg ggtgtgtgtg tgtgtgcaca 129360 cgcgcacgca tgcgtgctca ttcacactaa agaattcttg ggcatatgtt cctgaatgtc 129420 ctaaatggac attctaacat cacttcatta tgggcagagg gaaatggtaa agaaaaattt 129480 catattatat tattcagcca catattgaca gcatctgttt tatttgccta tggtaaagaa 129540 ttgaagcact gttaatttgc tttttaaatc atgtaggcac aaagttatcg aactttagat 129600 ttagaaatga aactggaaat cattacactt tccctttcct atccccaccc tgttttggag 129660 agaaagagtg tgaggcttag agagttataa aactgtttta ataccatgtc taagattaat 129720 aactgaacaa gtttctcttt ttactcgtgt taaagttgta ctgccaatta acttaaaaga 129780 aagaaatatg caatttctaa tcctgatata ggatatgggt atataaactc taacttgatg 129840 agtgaaacaa attaacttat ttataatcag tttcatatct ttatttattg agtgtcttta 129900 aatacccctt acctttaaag taagaaatat taaaatcaag cagaatataa taatgaaaaa 129960 ttcttaagat atacttacta aaaacttatc cttcggttaa tacactgtat gtaggttgta 130020 catacaatat gaaaaagtat atttttgtag cctactttta aatccagaat agaggaggtt 130080 aagaaggttg tgataaccat gagctctttt tttttttttt ttgagacaag gtcttactct 130140 gtttcccagg ctggagtgcc gtggcacaat catagcttac tgcagccttg aactcttggg 130200 ctcaagcaag ccttccactt cagccttcca agtagctggg accacacctg gctaattttt 130260 aagtattttt gtagagatga gttctcacta cattgcccag gctagtcttg aacccctagc 130320 cttaagcgat cctcccacct cagcctgcct aagtgctggg attacaggtg tgagccactg 130380 agcccagccc tcttttattt cttttgatag tacactcata atcattaaac tatcatttct 130440 ggatgtgaga ttgtgctttt ggattcttat tttttcttta taaaatactt tttgttctct 130500 tactggagaa aacattgttg gattataaat gatataacaa ggaatgagga tatacatact 130560 ataataacga ttcagatatg ttattttcat attttattta actgtagcca tgccacaata 130620 atttagagtt ttaaagaaca agtttgattg aaatctaaac tttgtacaat cctgaattga 130680 gaagtttcct gtattttatt atgacacaat atttacctaa aaatagagta attatgaatt 130740 gagaaaacat agctattaat ttcatactct tatttgttaa gtagattttg tctggaaaac 130800 tgttcatatt taaaggagct ttgtaccttt gtattctttt tgtttttcct tgtttatata 130860 attttaaact ctgtttatgg atttgggatt ctaactatgc taaataataa attaaggcat 130920 tgaatgaagt acctagacag tattttgatt aattttattc ccccattctt aatgtgcatg 130980 taactggaaa attaagagtg gcttccaagg gatctactac aaaagtaagg ttaatatgat 131040 ctcttttaaa acactgaagg cgtgtagcca gtgttgtcat taattctgca gtagatattt 131100 tcagcactta tttacatggg aagttagagc agagtaagat gcacctgtaa agctaaatgc 131160 cacttatttg catatatata aaacgcagga tgaatttacc atagaaatat aaagggtact 131220 tatagaaatg tattagaaaa atatatgaat ttttaactta tatctagaag ttaactttat 131280 acatttaact ttaaatcatt aatagtggtt taacaccata agcggatgtt tatgcatcat 131340 cattttatga acaaaagaca ttctaatttt agaaataaag tgattcaaaa gagaataaaa 131400 tatcttactt tttcttttaa aattaatttg tttagcgcat tacatgataa tagctcaagc 131460 ttgtgtgatt tttccctaaa aaattggttt ataaatatta catttatagt atgaagaaat 131520 taatcataca tagtttattt atctaatttc taaataccca tggaagaaaa tgaatttaat 131580 ggaatgtagt tgtgtattac ttggtttcga gtgtgggaaa atttatatgg tctttctaaa 131640 acagcactgt cagtagaaat acaatgtgag ctacatatgc aattttaaat tttctagtag 131700 ccacatttta aaaagtaaat ggatgcaatt tattttgata atataattta attagtctac 131760 tatatttaaa attttatcat ttcaacatgt aatcaatatg aaaattatta atgagatatt 131820 ttacatactt ttttctgtaa taagcctttg taatcaggta tgtactttat atatacaaca 131880 aatcttctga tgctaaattt taactggaaa tacttgatct gtgtttagct tttgtaaaat 131940 ttactgttga acaacgtgga ctaatgtgcc taagtggttc caaacatatt ttaaaatttg 132000 aagacaaata aaagggaact caaagtaaat tgggatacat acatacaaca gaatactgag 132060 ccattaaaaa atgatgaaat agtaaaattg ggggaatttt gatgatacta ggatgatata 132120 atgaccaaga gacaaataca attttagttt ggttgagaga tgtgatcatc acgttgctga 132180 ttttactatg tatagaggtt atcttttcct ttctaagatt ttgaaacttt aattagttaa 132240 cccacttacc tagtttctat tagctgtgta actttctctt cctgtttttt gttttgtttt 132300 gttttgtttt ttgcttttta actgcagtat tttgaggagt cttggagtag caagctaatc 132360 tttggaagaa aggaaaatat aaacctgaaa actaacaatt taaagaacgt cttttcaggt 132420 tgtcatttga aaaatacttg atttctgatc actgatttga attgagtgtc aaatatttga 132480 tatgttttgt aaattaggtg aagatgagtg agtaggttct aaactgcttg ggtttaccgc 132540 actctggagc attgcagaag aatgtgatgt tggaaggaag tgctgaaaca taattattgg 132600 cttgcctata ggagggtgct acataatttt agaaggtgtc aagaaattga cacagtctga 132660 attagttctg ttgagttgca aaaaatgtaa agtttcttga ttctgaaaat aagaaatatg 132720 ttcccagaaa tctcatctag ttaatgtgct tttaaaatca ttgatgtctc ttgttattac 132780 aataatagcc attgaaagaa tcttttttat tagaatgtta tttacaggta cgattagctt 132840 ctatttaaat aaattatttt tatacttgat cttaggcaaa aggccaacaa gtgatcagaa 132900 taaattattt taagagaaaa ctaattataa ttgatatttg gaattggaag cacaatttcc 132960 tttagaacaa ttccacgaat ggttgttttg attctcaagg cagcccacaa aagacagttt 133020 gaaacacaat ttatgcagtg tcaatagtac tgacctgact ttggatcttg gaggcagggg 133080 cttcaggtga tacccgagtg gagtttttac tccatttcca ttccgtaagg ctataggcat 133140 ttgaaagagg aaacttttct ttggcaacct tccaccttcc tttctacaga atatttcagt 133200 atttctagct cataggtttt ctaaaatatt ctctgtaatt tattttgaaa tggagttttt 133260 ttatcgttta cagatatgag taaaattagc ctaatcagaa tgttagttcc tgaaaacatt 133320 gacacgtacc ttatccacat ggcaattgag atccttaaac atggtcctga cagcggactt 133380 caaccttcat gtgatgtcaa caaaaggaga tgttttcccg gttctgaaga gatctgttca 133440 agttctaaga gaagcaagga agaagtaggc atcaatactg aggtattaat tatatataga 133500 attttcataa agtgtcagtt tgttcaattt gcatatccta gtactagaat gctgtatttt 133560 tttgaactgt tatgaattct gatatgatta ctttctctat gtgctacatt tcctttgctt 133620 ttcataaata tgatctgaga aaagtgatta aaaaaaagac agtaaaaggg aggtttagtc 133680 catctgttta gcttattatg tagaatgtca gcttaaattt tacctgtacc tcatattgac 133740 cgtatagcct ggaaaatctt tcggaggtat agttaatgga tttaagcata tggcagttta 133800 tgtagttaat gaaagtgaaa acaaattgta ttataaatac ctcccaaact ggtttattat 133860 cattctatca ttcttcatgc tctgttagta tgatattgaa tatctgaggt accaggatta 133920 ttgttgcttg tggctctgag catttcgtag tgcttttgca tgatgagaga aagattacaa 133980 atttagtatt atgttagatg gtacgtttta ttaaaatcaa atgcttcaaa aataattgct 134040 ctgtgtatgg catgagataa atagcaatca gatatattgt ttaataatat gactctatta 134100 aatgatggca taaatttgaa aatttgacct tcggtatctt ccgggtctaa aattatatga 134160 ctccattata aatattttgg aaatgattaa ctaaaaaatt gtttcaattc ttagttggta 134220 aattcaatgt ggtagtaggt ggtggtgatt attttgtatt agagaattag gaattacact 134280 tagttctaag gtaatcttta taggatgtcc agcaattaaa cccctacttt tttgaattgc 134340 ttaaaaataa gggaactgat ctttttaaat tctgtacttg agttacgtct gtatatatag 134400 tcatgtccta gataatctaa tggaacttaa ttagttggaa atctttatat tgtttataac 134460 tgaactagct ataagaggaa cattaaagaa aacatatttt gagtggaggt aatgaaattt 134520 agcttctaat gctcagcctt ttatttctgt aatctatacc agatacctaa gaccctctta 134580 ttgtttccca gcttcaacct gtcagtatag aaaacggtgt aacttactat tttttctcaa 134640 tattgaagca catttgtagt gaaatattat tttaactata tattgccatt tttgcttttt 134700 ccctatttca gtaacatttt tcgctatttc agtaacatta catgtcaaca agagaatggt 134760 gggtattttg gggggggttg ggtggggaga aattttacta agcttgctag attctaaaag 134820 gtatacctta tttggcccct tttccccatt taggggaaca agggtgttgg ggctgggaag 134880 tagataagag gtgagtaagt catccaaagc atatgtcttc attagcctcc ctgtatgaaa 134940 agctgatttc tgtagagtgt tggaggccta ctttcagaat ctgtcatatg ttaacattca 135000 tcttctctac tgacctgatt tatatccctt agtctatttc attttataat tatgacaaag 135060 gataaagtca ttagaacaaa ttctttttat tagttgacgt attgttgtgt ttatatctct 135120 tgtgtttgtt attaagatgg aagctcaatc atgtccttgt ttaacagaaa ggtgatgtct 135180 tggcattgat aattctgatt caatatccat aggtacatgg tggattcttt aaatatttag 135240 tattctttta tttctggaaa gttttcttaa atgatagttt ttttaaaatt tcatttctat 135300 aaagttttct taaatcatac tttttagtgt tttattccat tacttcatat ttcttcttca 135360 ggaactcctg ctatacatgt atgttggatc ttcattaccc agcttcaata tttttcactt 135420 ttcatgcatt ctttttattt cttcatttct ctttaaattt ttttcttcct tttcaccttc 135480 tatttctctt ttaacataat tgtatttatt tctgtattcc acatagctta gtattcactt 135540 attttaaaat tattttaaaa cgttttttag atttaaaaat tcttttttta tttatatata 135600 catattttat ttttaccaaa ggagcaacac tattaactga agacttctat aatttttttc 135660 ttttatttct gattctttct tcggttttcc ccctcagttt tgaacttttc taattttgat 135720 ttgtgatgtc cttttgtatt ttagataatt ttcctaatgt tttccagctc atttggaaag 135780 gctacagttt tattctgtac ctaagcaagt ctttctggtg tcaaagattt gaccttgata 135840 cttttctttt gctcattttc gtatgagatt agttttcctg tactttcaaa agaaggcgtg 135900 gttcaagatg gctttcccaa tttcacatct gtctctaatg tttttgtgta atgtctaaaa 135960 tatggaaact tggtttatga gatctactct gccattttta tctgggcttt ctcttccttt 136020 tgtctctgtt gtacctgtcc tgcttggttt tgatttaacc ccagtggttt ctcctgaatg 136080 tggagccttc tcctagaagg cagcctcggc tagtcccagg gttcagagta gccagctgct 136140 ctcttcacct aagagaccac tgtggattcc ttgtactcac ttgctattgg cttggacaaa 136200 agccctccca ttttcagatg ctattatcag attaatctct cattaatctg tctttccagt 136260 gtatgcctgt gggctatctt ggggttctct tgttatcaga cacctccctg ctggcctctg 136320 ctttctcccg tacagatgtc agtactgtgc aggtcttaat tgctgttggt ggtttgcccc 136380 tacattctta cagttttagt ttcccaagga tacctttaaa cttggtttta ttgtaaatgt 136440 cgacaatgga ttttgggttt tactatctag ttctgtctta attctggaat tcagaaagat 136500 taaaagctct gttgttgcag ctgctgccac ctcttcccag taccctctcc tcctatgtca 136560 tttttttctt cttatttttc ttgactgtat aagagagaat gtatgacatt tcctgcttga 136620 ccgctgagtt tgattataaa ttaaaataca caatatttta tacaaattgt tttgtagaag 136680 atttatttac agatgctcat tcacaggtaa aattgactta tgaaaatagt tttcatgaca 136740 aatgtatcag gctcggtaac taaatatatg gattgatctt gtttataaat gaaattaaat 136800 gtgaatgtaa cttacatatt tctgtatttg cttacatccg tatgtacaca tataatcagc 136860 aaatgagttg atgtttccta ttcgtaactt aatggtaata gcttggtaac agagttggga 136920 gtattaaaaa gatgtaaaga gccccttaaa attttgttgc tgggaatttt agtgttctac 136980 tgatgaagga aatagacact ggaaggcgtt gtttctatta ggtaacttag atatcatact 137040 gaagacttca aatacttatt gttgacactc aaaagacaca cttagtgtaa gtaagcattt 137100 ccccgctttt cccaatgaaa taagatcatt attataattc cattataaat gctgatgatc 137160 atatttatag aaatatagaa gataagactt gaaatgatat tcgctaccaa ttaatgagtt 137220 tgaagaagaa atcaggatgt gttttgctat tttacattta ttcttattta actccaaaga 137280 attcagtgat gttatgtact attatttcca tttctctgtg aagacgttga agcttaagta 137340 acacgcataa taaggtcata catttagcaa gtggctcaat taaagttcaa acctggttct 137400 gcctggtttc aaagtctgtg ctactccatg gtattaggct acaacatgac ttagggtttc 137460 ttcctctgct ctattgctgt tcagatgtac tcctcttttg gcagagtggg agaaaatttt 137520 tgcaatctat gcatctgaca aaggcccaat atccagaatc tacaaggaac ctaaacaaat 137580 ttacaagaaa aaaaaaaaaa cattaaaaag tgggcaaagg acttgatcag acacatctca 137640 aaagaagaca tttatgtagc caacaaacat atgaagaaaa gctcaacatc actgatcatt 137700 agaaagatgc aaaatgcctt ttctgtatgc caccttatat ccccagtatt tattatttct 137760 aagtcatagt atcttacagt gtatataagt ctcatccgtt cttttgattt tctcttccct 137820 gcttgcaatt gggtacctag gaacaaagtt gcaatcttag ccagtttttt ctttagcctt 137880 tgctgatgtg tgaaaagccc ttttttctac cctggatttc tgtacttaag ctggaacagc 137940 taagttttta ccttttttaa atataaagtt tcagagtctt ctgccaagga tcttttgctg 138000 ttttcctact gttaaatatt tcaaagcctt ttttaaacat agggaatata atcaaacata 138060 gcaagcagct gatgaacaat atctagatag tcttcattat tgaaatggaa taaatggtat 138120 ttttgtattt taggctaaca gacaccttgt accttagata aggccaacct tctcataaaa 138180 tccctcagtt acttttatta ataataacca aattaactct ggattccagg gtgtactcat 138240 gatggaatga tttctctgtc atgttatcct gaggatctag tactctgaga taacataagt 138300 gtatgacact ttaggcttat gaaacactta gctacttaaa ttatttaatt ttttttcatg 138360 tgcagatggt attgtaccca aacactacct ttgtgtgtgt gtgtgtgtgt gcctgtgtgt 138420 gtgtttttga gacagggtct tactctgctc aggctggagt gcagtggcgt gattatagct 138480 cactacagcc ttgacctcct gggctccagt gatcctgcca aagtgttggg attgcaggcg 138540 tgagccacct cacccagcct taaattattt ttttttcaag gatgtttaac ctgagggtta 138600 gaggctcttt ggcacgtgag ctgctgaaat gtgtgtgaaa gtgttgtgca cgtgtatgtt 138660 tctctttttt tctgggaagt ggatctgtag tgattcttag atgagtctat gagacaagaa 138720 acttttattt ttttcattta tttagcgaat gtttgttaag cgtactatgc cttggccact 138780 ctacagggtg ctgattggac cagtctgtct acctaccgtt gtagatgtta gaagctatat 138840 tcttttcaca tgcctaatat aactctttgt gtatgtatac atgcccaggc atgttccttc 138900 ctcagaacat taaattcacc attttggtca actcaaagca agtacaccat gggacacaga 138960 tctgaaataa tgtccagatt tttacttact gaatgaggtg tgttgagtgt ataagactac 139020 atgatgagat ggcaagtaat tgcctgaaga aatgatgtag tgattttgtg tgtcttatat 139080 ttatttactt tttgatccag aaataaatta tatagatacc actattttgt ttggatgggg 139140 gagaaaggat gggtgtgtat tcaggaactt atgttacttt tttgcaacta ataccccttc 139200 tcagtagtac aaagatttga tttctttttc tttctatttc ctacagactt catctgcaga 139260 gagaaagaga cgattacctg tgtggtttgc caaaggaagt gataccagca agaaattaat 139320 ggacaaaacg aaaaggggag gtctttttag ttaagctggc aattaccaga acaattatgt 139380 ttcttgctgt attataagag gatagctata ttttatttct gaagagtaag gagtagtatt 139440 ttggcttaaa aatcattcta attacaaagt tcactgttta ttgaagaact ggcatcttaa 139500 atcagccttc cgcaattcat gtagtttctg ggtcttctgg gagcctacgt gagtacatca 139560 cctaacagaa tattaaatta gacttcctgt aagattgctt taagaaactg ttactgtcct 139620 gttttctaat ctctttatta aaacagtgta tttggaaaat gttatgtgct ctgatttgat 139680 atagataaca gattagtagt tacatggtaa ttatgtgata taaaatattc atatattatc 139740 aaaattctgt tttgtaaatg taagaaagca tagttatttt acaaattgtt tttactgtct 139800 tttgaagaag ttcttaaata cgttgttaaa tggtattagt tgaccagggc agtgaaaatg 139860 aaaccgcatt ttgggtgcca ttaaataggg aaaaaacatg taaaaaatgt aaaatggaga 139920 ccaattgcac taggcaagtg tatattttgt attttatata caatttctat tatttttcaa 139980 gtaataaaac aatgtttttc atactgaata ttatatatat attttttagc tttcatttac 140040 ttaattattt taagtacctt tatttttcca ggatgtcaga atttgattct aatctctctt 140100 atgtagcaca tgtgacttaa tttaaaacct atactgtgac acagagttgg gtaaacgatg 140160 attatttaac tttaagcagt tcaccatcca tttcaaagcc tttgattggc ttttttgtaa 140220 ataaaaataa cttgttaaga aacaaatata tctgtcatag aagaactaga aaatccaggg 140280 aagtgagaaa aatgaaaata aaaatcattc atagttttac tagtagctaa tcacagtcaa 140340 cctcttttgt gtatcccacc agactttttt atattcattt gtttttagtt aaaatataaa 140400 agtctcgtat attcccattt ttctgcattg cattaccaga aggtagtggc gcctattaaa 140460 tatgtgatat gttgttgtcc agccatggct tctgcatttg catgcttttg tgtgtgcatc 140520 tgcaataccc tgtgaatatc ctgtgtgatg gagtggcaag tacgcacaga cacgtctgct 140580 gcatgcctag gtacgaggct gtctccagga gaagcacttg tttgattatt tgagttgcca 140640 attgaatttg ctgctttttt tcatggcttg ccattttcac tgaaaagaat gactaatgaa 140700 aaacgatgat tggttattag atttggatgt ttggcagaca ttttctcaaa attgaactaa 140760 gttggcctct tcacggaaaa caactggtat ttgttgtgcc aatgataaaa ttggagattt 140820 ctagcaaaat gtataatttt ggaaaagttg tgttcctcca ctggaagctt gacagctttc 140880 cttaacataa agacttctct ttctcttcgc tttcactact actactacta attcttcttc 140940 tgattcttct tcttctcctt cttccttctt ccttccttcc tcctcctcct ccttcttctt 141000 cctcttcctc ttcttctttc tctctttcct tccttccctt cccttcccct tccttccttc 141060 cttccttcct tcctccctcc ctccctccct ccctccctcc ctcctttctt tttctttctc 141120 tttctttctt tctttctctc tctctctctc tttctttctt tttctttctc tttttctttc 141180 tttcaagcag tcctcccgcc tcagtccccc aaaatagtgg gattacaggt gtgagccacc 141240 atgcacagcc ttacataaag ccttttctaa tgagatggat agtaattaac aaatgtgagt 141300 ttttgatatt atataaagat tttttctgtg tttcgaagat ccgtataact cagtgaatca 141360 gtatgttctg gatgactaat atgtgatgtt aagaaatcat gactgaggcc gggcgcggtg 141420 gctcacgcct gtaatcccag cactttggga ggccgaggcg ggcggatcac gagatcagga 141480 gatcgagacc accctggcca acatggtgaa accccgtctc tactaaaaat acaaaaatta 141540 gctgggtgtg ttggtgcgtg cctataatcc cagctactcg ggaggctgag gcaggagaat 141600 cgcttgaact caggaggcgg agattgcagt gagctgagac tgcgccactg caccccagcc 141660 tggcgacaga gcaagactcc gtctcaaaaa taaaaaaaga aatcatgact gggtaaaaga 141720 tctgttcaga gtacaagatg gaccaatgga tttgatatat ttgaatataa cagagtatga 141780 aaaagtttat tgatatagtt tcagattaca cactgcaact aatctttaag aaactattac 141840 ttgtccactt tttggtaaaa tttcagagaa caatgtccac cattatctga acaggctatt 141900 aaaatactct tctcttttcc aactacgtgc ctgtgcaaag tcagattttt ttcatatact 141960 tcagccaaaa cagcatatca aaatggattg aatgcagaag tagatctgag aatacagcca 142020 cttttgttaa gccagacaat gagatttgca aaatgtaaac aatgctgctg ttctcagttt 142080 ttaaaaatat gttttttaaa agtatttatg ttaatgtgta cttggtttac tactgctatt 142140 tttaaataaa acaagaaaca tttttaaatg tctgttttaa tttctaaagt ggtagtgata 142200 gatataaccc atattaataa aagctctttg gggtcctcag tgattttttt ttaagagtat 142260 ggaagggttc tcagacctaa gagattgaga aatgctgatg taatgtttta ttataaaggt 142320 gtaccatgaa ttatgtacct tacttcatat tgttggacat taaagttgct ttcagttttt 142380 ttgttttaaa 142390 <210> 6 <211> 142390 <212> DNA <213> Homo sapiens <220> <221> gene <222> (1)..(142390) <223> c.IVS28+2T>CiExon28 skipping mutationj <400> 6 gcaggaacgg gggcggggac ggcgctggag gggcgggtcg ggtaggtctc ccggagctga 60 tgtgtactgt gtgcgccggg gaggcgccgg cttgtactcg gcagcgcggg aataaagttt 120 gctgatttgg tgtctagcct ggatgcctgg gttgcaggcc ctgcttgtgg tggcgctcca 180 cagtcatccg gctgaagaag acctgttgga ctggatcttc tcggggtaaa gtgtcttcct 240 attcccgttt tcccagctcc gtgccccggg gtatctatag tgctaggctt ctgagacacg 300 tggaggcgct taggcccgcg gagcaggccc ctgggctgtg tttgggagat tctggaaaaa 360 cagactttct cccttttcct ttcccctctg gagcagctgg gaaaggcgtc tctcggagct 420 tccgccattc agaaagtgtt tccccgcccc tgacggcccc agcttgatgt ttaccttgcg 480 cgcttagtta ggattgctct ttctagtacg gcctttatta tggcagaaat tgagccacta 540 caggtctgca cagcaaagtc gagggaaata acctgctgtc tatgatttag caagtgatga 600 tggatatttt tgagttcaaa tcactcagtc tttaatggat tttcttttct ttttttccta 660 gttgaatctc agttgttctc aggctaggtt tgatatgaaa aatactactc cctattgaag 720 agggtaatat aattcttagg atgctaatac aggagtctgt aagtcggagt acttcaggct 780 ttttatggtt cggtacattt ctttttaggg gtgggatatt gggataagta ggacagttca 840 gatcttgatg tcattgaata gtggtgtcta cctaaaagga agaggctggg gcacaaaatt 900 ataatttaaa gtgtttactt cagccaaaat gaggacagct gcccaggact catttcccag 960 ttgccttggg gagtgctcct tcagccttgg ttacaagcag gtttttaaag gcgaagggga 1020 agagtgggct gagacaaagt tggtcaggaa ttgttattgg tttacagaga taccattgct 1080 tagtgattgg ctgtacactg taactcatag ggtatgagtt atcgtgtcca gcatatggca 1140 ttttatggct tcttggttcc agtctagagc ccatatagca ggtgggcttt aagagataat 1200 tatccagctc agaccgggag tgagacggga ctgttttttc attctaatgc ctctctgggc 1260 ctgataattt aaaggggctt gcattcttca gctaaaattt tattttcttt tatttttttt 1320 cccccacagt ggtctccctt tattaatcca acaaatgttt attaaggact gctctaggca 1380 ctagagatac caacaatgaa caaaacagac aaacatctct ctccttttgg agcttacatt 1440 ttagtggaaa gagacaggca aaaagtaaaa ttataggatg acagaaggtg aaaatagaga 1500 ttaaaaagga aagggggatg aagagtgtgt gtgtgtgttg tgggtggggg gctgtaggga 1560 gctgcagttt tacaataagt ggtcagggac gtcctcgctg agaagggaat ttttgagtcc 1620 agagctcaag gaagtgagag aacttacctt gacgttctct ggaggagaag aaagtacaaa 1680 ggccctgggg gaacctgcct ctttatgttc agagagcaac ttaagaggcc tagtgagctg 1740 gagcagagcg gagaggaggt cagaggtcag gccagaaagg gaaaggggcc agaatgtgta 1800 ggactttatg ggctatattg aaaattgggg ctttcattct gagggagatg ggaagctgtt 1860 ggagagttgt tagggaaacg tgatctgaat tatgtttcta aaaaattgga gtaagatatc 1920 ataaaatttg ccatcttagt cttttttgta tctggccaat tccactcaga attctttttt 1980 aaacagcttt attgagatat aattaatata tcatatgatt cactcattta aagtgtgcaa 2040 tacaatggtt tttagtttgt cttcagagtt gtacaacctt tatcacaatt acctttagga 2100 ctttttcatt acccaaaaga gaatctccat aaccattagt actcaatccc acccgctttc 2160 ctagcaatca cttacctatt tttttgtctc tatatagctc tcaaacccta tgatattcct 2220 tctatctaac tgtatttttg tactcattaa cagcctctct tcattcccac cacccatcca 2280 tcccagcctc tggtaatcac cattctactt actacctcaa tgacatcaaa ttttttagct 2340 cccacatata agtgagaaca tgcgatattt gtctttccct gcctggttta tttcacttaa 2400 cagaatgtct tccagttcca ttcatgttgc tgcaaatgac aggatttcat tctttattat 2460 ggcttaatac tattccattg tatatgtata tcacattttc tttatccact catctgttga 2520 tggacagtta gcttgattcc atattctggc tattgttgaa tagtgctgca ggaaacatgg 2580 aagtgcagat agctctttga catactgatt tcatttccct tgaatatata ccctgtagtg 2640 gatttgctgg acccgcttgt agttctacat ttaatatttt gagttatttc cataatgtta 2700 gtaataattt acattcccac caacagcgag gaaggagttc ccttttctcc acatcctcgc 2760 caacacttat cttttgtctt tttggtaata gccattctaa caggtgtgag gtgatatctc 2820 attgtgattt tgatttacat ttccctgatg gttattgatg agcaatgttt catatacttg 2880 ttggttattt gtatatctcc ttttgagaaa tgtctattca ggtcttttgc tcatttttta 2940 aatatggttt tttaattttt ttattttttt gctattgagt tgtttgacat ccttaaacat 3000 tttggaaatt aacctcttat tagatgtata gtttgcaaat attttatccg attctgtaga 3060 ttctgtcttc agtctgttga atttgctgtg cagagaagca ttttattttg atgtaatccc 3120 tttgtctatt tttgcttttg ttacctttgc ttttgaagtc atatccaaaa aatcattgcc 3180 cagatcagca gtccccaacc tttttggtac caaggactgg tttcatcgaa gacaattttt 3240 ccatccacag gagggagggg atggtttcag gatatttcaa gcgcattaca tttattgtgc 3300 actttgtttc tattattatt acattgtaat atatagtgaa ataattatac aattcaccat 3360 aatgtagaat cactgggagc cctgagcttg ttttcctgaa acttgagggt cctatctggg 3420 agtgatggga gacagtgaca gttcataagg cattaggttc ttctaaggag catacaacct 3480 agatcccttg catgcgcaat tcacagtagg ttttgcgctg ctatgagaat ctaatgccac 3540 cgttgatgtg tcaggaggtg gagctcaggt ggtaacgtga ggaatgggga gcagctgtaa 3600 agaaaaatga agcttcgctt gcttgcctgc tgctcaccta ctgctttgtg gcctggttcc 3660 taacaggcca tggactggta ctaatctgtg gccctggggt tgggaacctc tagccctgac 3720 caatgttagg gagctttttt cctgtgtttt cttcaagtgg tttcatggtt tggggtctta 3780 catttaagtc tttagtccat tttgagttga tgctgtatgt ggtgagagat aattgactac 3840 tttcattctt ttgcatatgg ttatcagttt tcccaacacc gtttattgaa gagcctgacc 3900 tttccccatt gtgggttctt ggctcttttg tcaaaaatca gttggctata aatatgtggt 3960 tttatttctt gggtctctgt tctgttctat tatctgtgtg tctctttatg ccagtaccgt 4020 gctgttttaa ttactagagt ttagtatatt ttgaagtcag gtagtgtgat gcccctagct 4080 ttgttctttt agctcaacat tgctttggct attcagagtc ttttgtgagg ataatgtttt 4140 caaggttcac ccatgttgtg gcatgtatca gaactcgatt tctttttatg gctgaataat 4200 attccatttg tttatattat atatatgcca tatttattta ttcatatgtt gatggacact 4260 taggttgttt ccaccttttg gctattgtga ataatgctgt tattaacatt ggtgtacaag 4320 aatctgtttg agttcctatt ttcaattctt ttgggaatat acctacgtgt ggacttacta 4380 gatcacatgg taagctttta gtttagcttt ttaaggaact gctaaaactg tttttccatg 4440 ggagcagtgt acaagtgttc cagttctcca tatgctcacc aaaacttaat ttcctttttt 4500 aaaaattata gctatcctag taggtggtgg gaagtggtat cttactgtgg ttttattttg 4560 tatttcttta atgactaatg atgttgagca tcttttaatg tgcttattgg ccattatatg 4620 tcttctttgg gaactgtcta ttaagtcctt tgcccatttt ttaattgagt ttttttttct 4680 gttgaattgt gggagatctt tatatattct gaatattaaa cccttattgg gtgtatgatt 4740 tgcaaataat ttctcccatt ttgtgggttt tcttcacttt ttgatattgt tctttgattc 4800 acttttaaat ttttatagag tccagtttat ctgttttttc ttttattacc tatgcttttg 4860 gcatcatacc taattcccaa atccaatgcc atgaagattt tctgttatgt tttcttttaa 4920 tagttttata gttttacttt ttctattgga gttttaagta aattcttgta tattagtgtg 4980 atacatttta agttattttt gtatatggtg tgaggtaggg gtccaacttc actcttttcc 5040 atatggagat ccagttgtcc cagcaccaca tgtttaagag tctattcttt ccccactgaa 5100 tggacttggc acccttgtca aaaatcaatt ggtggtaaat gtatggattt actcctggaa 5160 tctcaattct attctattgt atttatattt ctgtccttat gcctgtacca cactgttttg 5220 attacagtag ctttgtagta agtttagaaa ttgggaaaca tgagtcctcc aactttgttc 5280 ttcttttcaa gattattttg gctatttggg gtcccttgca attctgatga gtttgaggat 5340 caccttttcc atttctgcag aaaagccttt tgatagggat tgcattgaat ctgtagataa 5400 ctttgggtag tattgacatc ttaacaatat taagtctttc tatgcataaa catgggatat 5460 ctttccattt atttgtgttt tctttaattt ctttcagcag cattctgtag ttttcagagt 5520 acacgttttt cacctccttg gttaaattta ttccttggta ttttattctt ttagctgcta 5580 ttgtaaatgc agttactttc ttagtttcct ttcagattgt tcatttctgg tgtataacaa 5640 cagctgatat ttcaacgttg atgttgtact ctgaaacttt gttgaattta cttattagat 5700 ctagtagctt tctttgagat ttttatatgg gattatgtca tctgtatata gagatagttt 5760 tacttcttcc tttccattat ggatgccttt tatttctttt ccatgtctaa tttctctggc 5820 tagaactttc aatatgatgt tgaaaagcag tggtgaaagt gggtatcttt gtcttgcttc 5880 ctatcttagg tggaaagctt tcagtctttc accattaagt atggtgttag ctgtgggttt 5940 tcataaatgc cctttatcat gttgaggaaa taccctttta ttcctagttt tctgagtttt 6000 tatcatgaaa gggtgttgga ttttgtcaaa tgccttttct gtgtcaattg aaatgatcat 6060 gtatttttcc tcccttatct taatgtaatg tgttatattg attaattttc ttatgttgaa 6120 ccacccttgc ctttctgggg taaatttcag tcacttatgt tatatagtcc tttaaattgt 6180 gttatcttat aacagaatca ctctgctact gttttgagca taggccatag ggaaaagcag 6240 gtaaaaggta atatggcttg aaccaacatt gtagcagcgg aagtggtgag aggaggtcga 6300 attttggctt tgttttgaag atagaaccaa cagtatttgc tgacagatta gatgcagaat 6360 gtgaaaggag gagatgagtc aggatgaatc caaggctttt ggcatgagca accagaaaga 6420 tgaaggtgac ttactaagat gggaaatata caaaaggagc agtttgggga aactttatat 6480 ctattgagtg gaatatgcca attagagatt caaatatcca gtaaataatt ggctatcaaa 6540 gtttgaagtt aagaggaatg gtctaggctg tttatataac tttggaagtc attagtgtat 6600 aacagctaat ttaaaagcca gcagactcta agggagtgag tgtagaggga gaagagtaga 6660 ggtctgtgac ttgaatcctg gaatgctgtg atgtttagag attggggagg taagaaggag 6720 cagcagagta tactgaaaag ggattgttat actgaaaagg gattgatata gatggagact 6780 caagaattat cacagaaacc tgataaaatg tttcaagaag atgggtgtga ttaattgtgt 6840 cacttactgc cggtacattg actcagatga gcgttgagaa ttggctatag gatttgacaa 6900 cataaaagtc attggaaacc ttgacatgag cccttttcgt ggagtggagt ggttacagtg 6960 ggtttaagag aggattaaag gagtggaaac agagatgcta ttatagatga ctcgtttgag 7020 tagttttcct acaaagggga gaataataat ggagcagtta gccaaaagtt gagttttttt 7080 ttcttcttct tttttttagt tggaaaaaat tgcgtatatg ttgatgggtc ttttctggca 7140 gaccagtaga gaggaaaaag ttgatgatgt aggagatggg aaaatgtctt tgagtagatg 7200 tcttcgagaa aatgtctttg agtagatgag aggtttgcac acatggagag gttggatgta 7260 ggagtactga tagttcatcc atagttacat aagaaaaggt agatgtatta gagttctcct 7320 gagaaacaga accaatggga gatctttata tctctgtgtc catctctatc tgtatttctg 7380 tctctgtatc tatgaagaga ttataaaagt tttaagatct gccaggagac atacccacgg 7440 gagctaatgg tatagttcca ggccagttgt gaaggcctga gaaccaggag agcctatggt 7500 gtaagttcca gtctgagtcc aagtctgaag gcaggagaag accaatgtcc cagctcaaag 7560 acaggcagag ggagcagatc ttcccttact tagccttttt atttattcag gccttcaaca 7620 aattgaaggc ccacccacat tagggagggc aatctgcttt actcagtcta ctgaatcaaa 7680 tgttagtctc acccagaaac atcctcacag acacacccag aataatggtt agccaaatat 7740 ctgggcaccc catggcccac tcaaattgac acataaaatt aaccaccaca gtagagtata 7800 tgggtacaaa tataattatg tgatatagat ttcagggtaa gagcctgtgg aaattcattt 7860 ttgattgctt ctagtgaaat cggaagcaag atcatcagct aagagtgacg atcggtggag 7920 gagatatgaa gtttaagtgg agaggagaag gtataaaata gtcttaggag gggaggatag 7980 taaatagatt agggaaaagt tgtaggattg ccaggaagta gtaagggccc acttgaggct 8040 ggtggtcaca aatttaaggt gagaccagtc aaaatggttg tgcttttcac ctgctgcatt 8100 cattcagctg cataggtaca ggcacagagt aggtcaagag ttctttttta ttcggggtta 8160 gagttttgcc aggagatagt aataaagcca gaagggcaat gaatttgagg gagtatgcaa 8220 ggaagtggct gttaacttgg agtttaaact agtcaagaag agaattaagg actgcccaag 8280 gggtgaggac aatgatatgg tagcagggcc cttaaaagcc ccagttagat gaaaagattg 8340 ttggaattga gtttctagag ggaatgaact tgaaaaacag gaggtgttgg ttggagagtg 8400 ggatatatgg aattgagatt atggaaggat tcagtcgttg gtaataacat agtatctttg 8460 taggaataaa taggtggagc aggatgcaga caagatcact ggaggagggc tggtcagaag 8520 actgggaggc actatctccc ttggatatta tacatcaaag cttgtgatct actagacaag 8580 tagtggggaa agggtaggat atagatatta atggctatag ttttgatggt gatggtcatg 8640 gtgatgatga tggtccatta acactcaact caaataccat caatttgatt tatatctaac 8700 accacaaagt taggtgttga gttacatgtg gttatattgt aactaatagt cagcccttca 8760 tggacttcta ttctttgatg agactcttct tgtaggagta gtaggtgcct taaagcacct 8820 tttcatagtt gtcagattga aatccttcac cagtgtttta ggttaaccct gttactgtgg 8880 aagtttctct tggctttctg tgtgggctgc ttctttgtct agttttacct tttggggtta 8940 gcatactatt gtgaataatt tattggtgag aaggtaagca gagaagtaga gtactctatg 9000 acctagtaat ttcatatcta ggaatctatc ctatagaaat gataggaatg ccttacaata 9060 cccacatatc cacaagggta ttcattgaac gttatttttg gtgaaattcg caagcaacct 9120 aattatcatc aatagggaat tgttaaatta tgatagataa aatggaattc tattcagtct 9180 tcaaaaagtc agatcaagaa gtggtcttac attttaatta tcccatcctg tcaacaagag 9240 tgtcttcagt tgcaagtaat ggaaaaacca ttcaaactga cttcagcaat aaaaggttat 9300 ttattggtct gtttcatgga gacatctgag gtagagtggc cttcaggcaa gttcactcag 9360 ggatccgact atttttctgg ccttattctt ggccctcttc tatgaaaaca ccttcagggt 9420 ggtttcttgt atgcttgtaa gatggctact tgcatcaacc atgaccacat ctagcaggag 9480 caaaagcatc ctttcccgta ccagaggaga gtcccgaaat ttgttgcaat tggactgcct 9540 tggaagcaat aattatggcc aggagatgga ggctagagaa ctgagacctg atcatagctc 9600 ctatccttga atcagttgta tagcaagggg aattggattt tccttaagac agttggattt 9660 cacctgtagt cttggtgatg aggtcagttc catccataaa actttgctgt tacacatttt 9720 gggatggggt gaggagggct gaatggagat taggatgcta ttgaaatttg ctgtacacaa 9780 tggatcatta tcgtcttctt tcttagtgtt aaggtaatca gcctcttttt cctcctccta 9840 tgcttgactt tactaaaacc atgagacatg tttaacctca ggactccaat ttgaaaaaat 9900 atagactgtt atttacttta ttacttacag aagcccttca tactactctc agcaagaaag 9960 aggtaggcag ggagtgaggg aggggggatc atgcttactg agaaacaaac tatcgagtat 10020 tgaaactccc ccttcatatg cctgacctca gtcccattca gttaccagta ggggccccta 10080 ttaattggta cctcaccagc ttttgctgtt cgttcataaa actgagtcat tgaagtacag 10140 tagaaaaata attggactac aagataactt atttccttcc ataattgcaa aatatctgat 10200 ttttcttctt gtttgtatta tgtaaactta ccctgtctga gggtcctcct ggattgttct 10260 ttgcatttat atatacatag aatttcattt tcttttttct tgtttttttt ttagacggag 10320 tctcactctg tcgcccaggc tggagtgcag tggcacaatc tcggctcact gcaagctccg 10380 cctcccaggt tcacgccatt ctcctgcctc agcctcccca gcagctggga ctacaggtgc 10440 acgccgccac acccggctaa ttttttgtgt ttttagtaga gacggggttt caccatgata 10500 gccaggatgg tctcaatctc ctgaccttgt tatctgcccg ccttggcttc ccaaagtgct 10560 aggattacag gcgtgagccg cttgcccgac cttctttttt tttttttttt ttttttttga 10620 gacgttgaga tagagtctca ctctgttgcc caggctggag tgcaatggca cgttttcagc 10680 tcactgcaac ctccacctcc caggttcaag cgattctcct gcctcagcct cctgagtagc 10740 tgggattaca ggcgcccgcc accatgctct gctaattttt gtatttttat tagagatggg 10800 gttttaccat ggtggtcagg ctggtctcga actcttgact acgtgatccg cctgcctcgg 10860 cctcccaaag ttctgggatt ataggcgtga gccactgtgc ccggccaatt tcattttcta 10920 ttttgaaatt taaactacca ctgacacttc gttttccctc tgttttactt agcatttatc 10980 ttagagaata atcttaatat gtatagttct attttattct tttactggca gcttagtatg 11040 ccatattttg gatgtgtcat tgtttattta cctattaatt taccctataa ctgcttccca 11100 tatttttgct tttacaaagg gatgtaatga acatccttta catacgtctt tgtgcatatg 11160 tgcaaatatt tccataggat agatgtaatt actgacttga aggttatgca gatttaaaat 11220 tttgatgcct tctatgaaac atctttcaaa atggtgatgc cagtttcttc tctcgtaatt 11280 actgcatatg gtcaatcttt taaatttttg ctggtaatga tatttcaaaa ttataaccag 11340 ttttttggcc tcatttcttg aataacttgt tttttctcaa agataagaaa tgtctccttc 11400 atcgtatgtc aaatttccat atttacatgg atctatttct ggacatggca agttttattt 11460 atttattgta tgtatttacg gtgtacaaca tgatgttttg atacacatat acgtagtgaa 11520 atgattccta cagtcaaaca aattaacatg ttcaccacct tccatagtct ctgcagtctt 11580 caaggttttc tctatatggg attagacatg ctatgtctga tctgtttttg tatttttaca 11640 ccaattccac actaattttt tttttttttt tgactgggag tctcgttctt attgcccagg 11700 ctggagtgca atggcatgat ctctgctcac tgcaacctcc gcctcccagg ttcaagcaat 11760 tctcctgcct cagcctccct agtagatggg attacagcac tcgctgccac acctggctaa 11820 tttttgtatt tttagtagag atggggtttc accatgttgg ccaggctggt ctcgaactcc 11880 tgacctcagg tgatctgccc gcctcggcct ccgaaagtgc tgggattaca ggtgtgagcc 11940 acctcacctg gcacacacta ttttaattac tgtagtttta aaagtttcat atttagtagg 12000 gtgagttttt ccttgttggt cttgtttttc aaaaaaaatt tgctgctctt gagtattttc 12060 tcttcccagt gaactttaat gtaaactcac gtggttcaat gaaaaattct gatgactttt 12120 tttcttggta ttgcttcttg agtgtattga tttaattaat atatttacag ttttgggtct 12180 ggctgtgccg aaacgcagtg tgtcttatcc agtccttttt taactgtctt aataaaattt 12240 gctggttatc tttaaaatgg atcttgtata ttttatgtta ggtttattcc caggcaggtt 12300 gtcatttttg ctgttactga ttttggatat aaattttgga tataattgta taatttggac 12360 ttggatataa ttgtatttga ttctgtctta tatataaaaa tgagatagga taataattta 12420 tcctaggata aaaataattt gagtatcctt attttgcatc tggtacctta cttgctcctg 12480 ttaaacaaat agataaaatt acttgtcttc aaagagatcc tgtggaaaaa ttatttattt 12540 taggagactt tggagctttg ataaaaatta ggcttatctt ttgtaaaagc tggttagtga 12600 tagcaatcag actcttttaa aggtgatttt tttttctttc ctttgataaa atgcttaata 12660 tgagggagga ttaagaaaga ggatggcttt tgaacagttt cttcatgggg aaataagaaa 12720 ttagaataat ttcatgttct ccaaaaaaag gagaaaaatg accttccctc ctgagcctac 12780 ttcaagcctc tgtttctttc tgactctatt gttctcatct ctgcattttt ccaatctctt 12840 ctactgttag tgttttaggc tagctcctca gtggagggca gaaattcacc ttctctttag 12900 ctgtctttga aaccaagaag atagaggtat gagatcttcg tagtctgtag taagaataat 12960 agaagccatc agaaaaaaat atcaaagctt tgtagctgct cctggaagtt ttgatgtgaa 13020 gcaggagaca tcacctattg gtacctgact tgcttttgct gttcattcat aaaacagagt 13080 ctctgaaata cagtagaaaa ataattagac tggaggataa cttttttcct tccaggaatt 13140 acacaatcac aaaattgctg atttttcttc ttattcatgt tacataaact tatcctgtcc 13200 gaaaagactg tatttgaact tactatgtaa gatttgcttt aggtaaattt atggctgctt 13260 ccagaattgt gtattaattt tccagtttct tttttaccag tctccacttt tacctttccc 13320 tcttccccct atacttaaat tggtcttact gtaaaattta tgcgtttctc tttctacctg 13380 gcaatgctga tttttttttt tttttttttt ttgaggcaag gtctcactct ttcacccagg 13440 ctatagtgca gtggcaagat cgtggctcac tgcaacctcg aatccctggg ctcaagcgat 13500 cctcccacct cagtctccca agtagctggg actacagatg tgtgccatcg cacctggctc 13560 atttttgtat tttttgtaga gatagtattc gccatgttgc ctaggctgga ctcaagccag 13620 cctcctgcct tagcctccca aagtgctggg attgctggca cgtaccacta catccagcca 13680 gggctgagtt tctgaatcat cattgcagca agagaaattg gattaccttt agaccactgg 13740 ctctactgtg ggctgggagt gggacacctt ccttaaagcg cattggacat tggctttgtg 13800 ggtaactgat ctttacctga atgaaattta tcagtactgt attaagggtc tagggtggaa 13860 cggatgctag caaggcaacc gttaacatcc acttactgat gaatcctata aaattttatt 13920 tcaggccata cgaagtaaca gtaataaata taaaaggaaa aatagacaac ctaagcaact 13980 ttttaaattg acttacttga aaactttccc tgcaatttcc cggtttataa tggttgattt 14040 cagctgactg gctatagcta cttagagaac agaggaaatt cattaaaaat aatgaattat 14100 tcagttgggt agtgaaatcc agttataaag cacttcgctg tgccatggat tcagttcagg 14160 tcaagtgatg ttcctggttt atgggcagtg tggcttctca ctatgacaca gcaaagaacg 14220 tagcttttat cctttaccct tgttactaac taaaattaat ggcattttat tgtgtttatt 14280 tgtttgattc catttacagt ttatttcact tggttttatt agtacaaaat tgtgctttat 14340 ataatatttg acagttagga aaaattgtta gatacctata aagaaacaag tctctcaaaa 14400 atcatcctac tacttttaaa aattacatcg tcttactaca gttaacctag atgtgaatgg 14460 gtagttttat ttagcttttc tggtttgttt gcttggtctg tttggaggga agttaagatt 14520 agcagaaatg tagtaataga ttcatgaaag tcttgaaagc ttctttaatt agagaattta 14580 atgagggctt tggcatgcat tctttggttt ttctctgttt tcctctaccc cttcttattc 14640 tttttggttc attgaaaagt agaaagaaat tctcaaaaac cgtacaggag aataccttat 14700 aaatgatatc ttctgcaata aactatagat tgtatatatg tatatgtatc tagatacaca 14760 atctgtgtgt gtgtatatat atgcttgtgt gtgtataaat gtataaatta gttactagta 14820 tatacgtaag tataaaacct caatgtgcaa ggttacattt tcagaaaata tgtaatataa 14880 taaaagaaat caagcccaga atttttaaaa agtttattgc gctttctgtt aaaaatgaaa 14940 ggctttttga ctggaagctg cttctcagta aaaataacat aattgtgttg gtgaagccca 15000 aagattctaa tgaaaattag ggtattgaca accaaacgga attgctggag tacttaagct 15060 gctttggttt tgtaatcttt ctgtgtcaga atatttgaaa aacacttatt aatccagtct 15120 tgtaacttat ccttgaaatc tcttttttaa tattcttttc cacacacatg aaaagttaga 15180 tgagtgtatg aatttctgtt gtcagactag ttgtaaacct cctaaatata gtttctgcag 15240 tatagttaaa gagaaagaac atcctggcta acacggtgaa accctgtctc tactaaaaaa 15300 aaaatacaga aaatgagccg ggcatggtgg tgggtgcctg tagtcccagc tactccggag 15360 gctgaggcag gagaatggcg tgaactcagg aggcagagct tgcagtgagc cgagatcacg 15420 ccattgcact ccagcctggg cgacagtgcg agactctgtc tcaaaaaaaa aaaaaaaaaa 15480 aaaaaaaaag aaagaaaata ggcccagcaa ggtagctcac gcctgtaatc tcagcacatt 15540 gggaggctga ggtagggagg attgcttgag gccaggagtt caagaccagc ctgggcaaca 15600 tggtgaaact ccatttctac aaaaaataca aaaattagct gggcatggtg gcatgtgcct 15660 gtagtcccag ctacttggga ggctgagtgg gaggattgct taagcctggg gaggttgagg 15720 ctgcagtgag ctgtgactga gcaacagagc tagactctgt ctcaaaaaaa aaaaaaaaag 15780 agatgggttt tgaaattcag tacttttttt gagtgaggtc caatgggtca gaaagaagca 15840 ttggataaat gaatccattt tctcttctct gtttgaattt gtaatttgaa agaatattct 15900 acctataaag tacttcagtg cttaattagc tgtcagtgaa tttatatatc ttatctaatt 15960 catatggatt tgctattttt atctgtacct acagattcct gacctctcta aggggatccc 16020 agtatactat agggaatgag gtataataga agtaaaagac ctatcactag tcctgtcatc 16080 attccaactc atgtgtaatt atagtttaaa agaagtgaca tcatgtgtat tgctgtttat 16140 ctttacatta atcttgtggt caagaaagca aatactataa tatataataa ttatataata 16200 tcataagaca agtaatataa taatgggaat ataatcccat tttacaaatg aggaaatgaa 16260 aatttagaga aataaagtga cttgtccagg gtcacatgga tactaagtga ccaagtgtca 16320 aagcagaatt ttccaaataa cttaaagata attcttgtac aaatatagaa cgaacacatg 16380 tcatatgtgt tgtgttaatg agggaaccag aaggatgaca acattggttc agagagatgc 16440 aaagataaat atagacattg gaggaaaaag ttggaaataa gattgttagg ttagatacaa 16500 agctgtgtta taggccaata aaaaccatag actttgaggt tatctttttt actggacagg 16560 attcagttac acctttatga gaccaaaatt tattatttaa catgtggata ttagagtctg 16620 agttttaaaa ttattagtaa atgaccgtca aataaagata tgtcccctaa tgaaatactg 16680 ataatcgctg ggtgagcttg tgctcctata tgacattgaa atgacatact gccctctctt 16740 tgtcttctaa gttttggata cttttttttt tttttttttg acacaaagct gcattagaac 16800 ctaggtttct tgattttcag tccagatttc tttccactct acttcctgct tcttcatagt 16860 ataattttca acactagagc agtctgcata acttttgcaa aatcagctag tctttcttat 16920 tagttttcct ttgtgcaaag tgatgtagat acagctttct tcttcagaga aacattgtga 16980 aattcaatga atatttgtaa aatttgcata cgtgcccaat gtgagaaatt gaaattatta 17040 cttaagtatt gcaactgttc ttttaggata ttttgtttgc aaatttcaga gtaattataa 17100 atattcttgc atttttattg taatcagtat ttataaaaca gtgtatttca tcacattaac 17160 ctttacatat tttgaataaa atagtattga accattttaa atagtaagtg gaaatttttc 17220 cacattaaac agtataacgg gctaacagag ttaagcattg cattatttaa ctaataattt 17280 tttcctgaac ttcagattat tatctgtatg tgtcatataa cttgacaatt tttttttttt 17340 agtgcttttt aaaaagagtg ggatacttta ttcagtttag ccctcaagca attaggcaag 17400 tcagttacca tggtaacagt aggtattaat ttccttacct agttagaggt tttatgaaca 17460 aagaaatctc tgagttcatc caccaaaacc caactttctc ttgagactgg cctcttgaga 17520 ctggtgttaa atttgtctat tttctagaag atgacactat tctaagtgga aaatacggtt 17580 ctcttgaggt gaatttctac tctatcaaga gtgaagtaga gtatggctta aaagttaagt 17640 gattaaaaag ctaccctttc ttagctaatt tggaatgtaa ttggtcttaa tttttctaaa 17700 ttcgttctaa ccaaaatctt attggcgtga tttctattga catgaactag aagtgacttc 17760 agcagacaac ttgtcccaat atctaaatgc tgtcaaatag aatcacttaa gatgaatttc 17820 ttccaaaaca gagttcacaa ttttgacaga taatctctta gcatttaatt gactagtatt 17880 accaacctta tggaataggt ccactcgttt agctatcatg aggaccattt tgcaactaac 17940 ttatcaaaaa gccttcacca agaagttgca tatcttattg atattttaga atgcgattat 18000 ggagattaaa aatcaccaca atgggttgtt aataacgcca gccttgaact ttcagtttta 18060 gagcatttta tctgtgttct gtagtcaaag ttggtaaggt gtccagtggg tcatgtttga 18120 cttgctgctt gtttttgtac tgtgtgctaa atggtttcta catttttcag tggttgaaaa 18180 gtcaaaagaa gaataatatt ttatgaaatt taaataaatc caggtttcag tgtctatagg 18240 taaaatttca ttgtaacgtt gttatgctta agtattgttt atgacttctt tgctatagtg 18300 acaaacttga gtagttttga caaagatcat ctggcctgta aggcctagaa tagttactgt 18360 ctaacccttt agagaaaaaa attgctggcc cttgttctat agtatgaaaa aatatagcct 18420 tgattattca ttaaaaaatt attttcccat tttattgaca tacttttgtc ccctgattgt 18480 taaaaggaat gcatgttctt atagaaaagt tggaatatat agaaaagtat aaagaacaat 18540 atgaaaaacc atttgcaatt gtgagataac cactaatgtt ttggtataca ttgctccaga 18600 cttacacaca aacacacacg cgtatttatt ttatacaatt agagtctaat tttttttttg 18660 agacagtctt gctctgttgc ccagggtgga gtgcagtggc aagatttcag ctcactgcaa 18720 cctctgcctc ctgggctcaa gtgattcttg tgcctcagcc tcttgagtaa ctgggattac 18780 aggcgtgcac caccatgtcc agctaatttt tgtattttta gtagagacgg ggtttcgcca 18840 tatgcccagg ctggtctcga acccctggcc tcaaatcatc ggcctgcctt ggcctcccaa 18900 agtactggga ttacacacgt gagccactgc gccttaattt tttaatttgc ttttttcact 18960 tgaataatta taagaacatt atttttaatg actgtgtagt gttctgtttt atggatgtac 19020 catacttaat tatttagtca taatttatta ttatgaggtt gataaacatg ataatcagat 19080 tgagctcaag aagctagtta tagggttgca caattaatga atcccaggta cctcgctggg 19140 ttgctgaggc tgctattttt ttcctgcctg tttggaacac tgtgtttggg accaatgagg 19200 caaaagaaat tgaagagctg ccattttcaa ttattctatt agaagataca ttgaagattt 19260 gtcaaatgac atagacacaa cactaatcca gaagattatt taatcaaaaa ggcattcatt 19320 tcagatatga attcataaac atttgtaacg atcctcagtt tgaagaccat atagaatccc 19380 tgaagaactg gaagacacta tttgcttggc aaagagaagt ccccagacca actggggatg 19440 aaatattcaa agagataaat gaatactttg aaacatacaa ggtactatgg aaaaagagtg 19500 gaagtttggg acaggtaatg acaggaagat ataaaagctt tacattaagt tcaatctaaa 19560 actttattcc aagtaacagg ttgtcttatt catggagaag cagttgtaaa ttaaaacttg 19620 cctgtggttt ggaatttcac attaaatgat tacattaaaa attcaaatgg tgaacctaac 19680 taaatccaag ctcctacagt accttctttt cacctttagg tgaagaaatg cggtgagcta 19740 ttttattact gattatgtgg acagtccaaa ggaaggttca taagcgaaaa ggaaaaattt 19800 aaattattcc atgtgagcga ttcttacttt gcagatttgt tgaagtgtag ttactggctt 19860 caaaaagtgg tatccttaac tgacattttg aacacttgaa ttcactcaat aaaaaaatgc 19920 agtgatcatg tggaaaatac attaaggtat atgacagagt ttatggattc agagcaaaaa 19980 ttcagctttg gaaaagtgaa gttaaaatgg ttttttaagt gatgtttaat tggtgttatt 20040 tgaatcctaa agaagaatta atagtactag tagaggaaag tcagtgtgtc tgtgacaaag 20100 ctttagtatt attttgaaat acttgatata aaaaagttca cgtttactca aagcttactt 20160 aaatcatcag aataaattaa catgtttctt aattaaagaa aaggagaagc tattagactt 20220 aaaaaatttt tgcacccttg aaatacatac aatttgaaga gattaagttg ttggaatact 20280 ggttaatggt gaaaaaggag ttttcagtct atgaaagcaa agccttctcc tttgccattt 20340 gcttttttgt agtggttgct atgtagaatt cgaagaaaat attgttaaaa agtcttggtc 20400 aggagtagag tgtagcatga acccaatgca ttttaacgtt aataatgagg aaaaagggaa 20460 tgcatgataa tttcatcaag tcagaaaaaa atggaaaaag aaaaagagga aactgaagaa 20520 agtaactgat gaaagtaagg tgaaagggaa aacaactttt tataccacct gtgaatgaga 20580 ttaattttcg tttccatact gaaagacaaa tatattccaa ttaagccatt caaaataaaa 20640 aacaattttt ttttggtaag agatgggatc tcactatgtt gaccaagtta gtcttgaact 20700 cctgccctca atcagtcctc ctgcttcagc ctcccaaagt gctaggattt caggcatgag 20760 ccactgtgcc tggccaaaac caaaattaag caacaaaaca acaacaacaa aaattccaga 20820 cagcctttaa aataatgata aaggttgaaa aattgtagat agtggtaggt agataagatt 20880 tcaggaaaag tccaaagcaa atcataatac gttattttaa aggggggttt aaaatccttt 20940 aaaggtacaa tgtgaagcat tatgaaatga taaaatacat gttttttaaa aacattaatt 21000 ttattttaag ttccaggata catgtgcagg acgtgcaggt ttgctacata ggtaaatgtg 21060 tgccatggtg gtttgctgca cctatcaatc tgtcacctac atattaagcc ccgcatacat 21120 tagctgtttt tcctgatgct gtccctcctc caggacccag tgtgtgttgt tccccatgta 21180 ttctcatcgt tcggctccca cttataagtg agaacatgtg gtatttggtt ttctgttcct 21240 ttgttagttt gctgaggata atggattcca gttccatcca tgtccctgca aagtacatga 21300 tcgtgttcct ttttatggct gcatagtatt ccattttata tgtaccacat tttctttatc 21360 tagtctatca ttgatgggca tttggttttt ttccatgtct ttgctattgt gaatagtgct 21420 gcagtgaaca tgaacatgtg tgtgcttgta tctttataat aaaatgattt atattccttt 21480 gggtatatac ccagtaatat aattgtataa cccagtaata ggattgcagt gtcaaatggt 21540 atttctggtt ctaggtcttt gaggaatcgc cacactgtct tccacaatgg ttgaactagt 21600 ttacattccc accaacagtg taaaagcatt cctatttctc catagccttg ccagcacctg 21660 ttgtttcttg attttttaat aaacgccatt ctgactggca tgagagggta tatcattgtg 21720 gttttgattt gtatacaaaa aagatttgta tttctctact gatcagtgat gttgagcttt 21780 ttttcatgtt tgatggttgc ataaatgtct ttttttgaga agtgtctgtt catgtcctct 21840 gcctactttt taatgggatt gtttgttttt tttttcttgt aaatttgttt gagttccttg 21900 tagattctgg atatagacct ttgtcagctg gatagattgc aaaaattttc tcccattctg 21960 taggttgtct gttcactctg atttgctgtg cagaagctaa aagacatgat tttagaaaaa 22020 gacatgtcaa agtcatacat gctcaacgac atagcgagta catatgtaaa taaaaaatta 22080 ttttatgctg tgaatttgac cgaaaataac ctttacctcg tcaggaatta caatcctcac 22140 gtatggtaaa ggatttccct attgcaaatt attccacaac attaatgttc tgtgtgcttt 22200 ttatctatcc caagatacaa gtaaatttga caaagatatt aggtttgtaa acaaatttac 22260 gttcaaatct ttgcctggaa gtatctagat agaattttgc atgcaaaaga gtatttacat 22320 ctaaaaaatt acatatttca aattaaaatg attttagtgt tatagataga aggaaagagt 22380 tattgaagtt tatttctgtt ttggcagtgt aaatgaatta cttacaaaat tttagaagtc 22440 tacaggtgtt tttataaagt ttgtgttatt tgtggaaacc tcagttttct ggcattttgc 22500 caatgaggtc tactctaagt atagcagaaa tttgttttcc agctttataa atatatattt 22560 taagattaag aactgatttt acttatataa tctgggatca acttttggct tctcctgtca 22620 aggattttga atttgtgaca aaatatacac ttattgataa ccagtgacat atataaaatg 22680 ctttacaatt aataaagcat atgtatttta catatttttt cactacatat gacgcatgtg 22740 gcaaccccaa gagttgagtt gtacccatcg gcaaactttg atcatgattc tgtgaatata 22800 ggcaagcacc aattgcaggt agaacattct ttttttgagt cccaaaccgt gagaaacaaa 22860 ttacagaaat gtacctttct tttgcattag gacacgttgt agttttgtat gaacactcta 22920 gttttaagca gtatgtgcaa aaacattgca caaaggattt gtgtgttgat tttgggactc 22980 ctgtattatt aattatgtgg tttatttgac taccccacat tttcaagcat aaattaataa 23040 atccataatt ccaggcttat taacaataaa caatctagat agttgaactc tttcttgcta 23100 acattttcta gatatggact gtttggtatt tttctactaa taaagaccct tagtaagctg 23160 ccttctggtt tgatgtcatt gggatgttta ctgggaactt tggtggagat cttgcagtct 23220 ctctccccca gtggtgaaag aatgagttac aaaccagctt tccttcccag tgtacaatag 23280 cgatggagtt tgttctatat ggaaaatttg tttgataaaa gtattcttta aaattttttg 23340 ttccataaat tatcagtatt ttcagtttct gattcatgct tgggatagtt gctgcatatt 23400 gtttaatttt gtcagaattt atattgttaa atatcaaata cgacagacta ccctcaaatc 23460 ataagtagtt aatgtaatta acatcctgtt tcatcatgag actcttcagt gttacattaa 23520 aaactgctac ctcctgggcc gggcgtggtg gctcatgcct gtaatcccag cactttggga 23580 ggctgaggtg ggcgatcgga tcacgaggtc aggagattga gaccatcctg gctaacatgg 23640 tgaaaccccg tcgctactaa aacatgcaaa aaattagccg ggcttggtgg cgggcgcctg 23700 tagtcccagc tactcaggag gctgaggcag gagaatggca tgaacccagg aggcagatct 23760 tgcagagagc tgagatcgtg ccactgcact ccagcctggg cgacacagca agactccgtc 23820 tcaaaacaaa aaacaaaaaa caaaaaaact gctacctcct tattacaaat aggaactaaa 23880 gttgaagttt gaggaatttg ctaagaacta agccttgaac taaggctatt ttatttgagt 23940 atgagtcata tcagggtacg gatccatttt actattaaca aaacaaatat gttctgtttt 24000 ttttttttaa atgcacacac cacgtttgag agattcttat tcactgtatt ttctttaatt 24060 atacttgaat tttggtttac attgaggagt gccctcaaag atattaacag atttttaaaa 24120 aatcctctaa aaaactcatt cttagggaaa tttgttcact tactaggtga ggagcaaaat 24180 aaaaatcctt aatatagaag agctattatc tgtcttcaaa attaagtctt tgagtagatt 24240 tgtgaataaa tctaatagtt ttgctgaatt tacttagatc ttaagacaga ataatcatgt 24300 agaaaattta aaatgtcagg aattcataat gattcatata cccaaggatt ttcattgata 24360 gtgaggtaag gttattcttg agaaagactc aaagtcataa aataatagaa tttcgaaact 24420 accagaatta tacaagtcaa ttaaaatgac tgatttgttt taagaggaag aaatactaaa 24480 tgtataatta ttagatgcag catattgtat ctgttttgtt ttgtgattct agctcttata 24540 acctatgctt ggacctaggt gtcataactt actttaaata tgtatgtttg gttttcattc 24600 atattgacag tactacctct cagttttctt tcagatattg ttttgtattt acccatgaag 24660 acattgtttt ttggactctg caaataggac atttcaaaga tgagtgaaaa aaaattggaa 24720 acaactgcac agcagcggaa atgtcctgaa tggatgaatg tgcagaataa aagatgtgct 24780 gtagaagaaa gaaaggtatg ttgttcattg actattcttt tgggtgagaa atttaattta 24840 tatttgactg tgcaaagagt cagttgttac ttgtaaactt caagtcattg tttaggtcag 24900 agttgctgtt gtctaaatgc accaggacct agttgttgaa agggtaaact ggaataaact 24960 ttaattgggt ttacaaaatg agaattctta ctgtatattt tctctttttc gggttgactt 25020 taccagtttg ttctagttca gataatttag acaacattaa ctttgttgaa ttttttgttt 25080 gccagccggt cttcagcatt ttaaggcaac attattatta cagttgtaat acgaatataa 25140 ttaccagaga aaaaactcag gaaaataaat gcttttatga aaatgggatt agaggtttga 25200 aaataaactt gttaggagaa ataatttcac aatgggatgg ttttttcttt gttaagtttt 25260 ctttatgact tcattagttt ataaaacatt aattgataaa acttagaact ataaattgaa 25320 tgcttcagtg aactttatta tttcagtgaa catttgttat ttgatgtgaa ctttgtgcct 25380 gttttgaaat ttactaaact caaggcatgt gttcggaaga gtgtttttga agatgacctc 25440 cccttcttag aattcactgg atccattgtg tatagttacg atgctagtga ttgctctttc 25500 ctgtcagaag atattaggta agtgatttga atttcctgat tttatttgaa tttggaccct 25560 tagaaggtac tattatggta atgtttgtga atatactgag ttttacaggt gaggtgtgtt 25620 caatagataa ttatttctat gtatacacta tcaccaagtt ttacatttca aataaaagtc 25680 actgaattaa tttgtaatct gtcagtttgt tcattcataa gcttttctat tacttcagac 25740 agtttttttt taactttttt aatatatgtg ctgctgaagc gagcacgaca gttttttaac 25800 tttcagtact taagatgtta tatatagagc tactgaacat actgtgttta ttttaccaat 25860 ttagggaaaa agtgcaaaaa ttatttaacc tttaaatgca cctttatatt tcattaaaaa 25920 tatcaacata gtaatattga ataatggcta tgatcggctc tgttgtgtgt aattagtaac 25980 agttgtagca aatgatcctt aaaaaatgtt ctaactaaac attagaggcc aggcgcggtg 26040 gctcaggcct gtaatcccag cactttgtga ggccgaggca ggtggatcac aaggtcagga 26100 gattgagacc atcccggcta acatggtgaa acaccgtctc tactaaaaat acaaaaaatt 26160 agccaggtgt ggtggcgtgc gcctgtagtc tcagctactc aggaggctga agcaggagaa 26220 tcgcttgaac ctgggaggca gaggttgcgg tgagccaaga ttgcatcact gcactccagc 26280 ctgggcgaca gagtgaggct ccgtctcaaa aaaaaaaaat ccaaaaaaac aaccccacaa 26340 acaaacaaaa aacattagaa atgtctgtta gtacttttaa aggttgcctt gtaaaattag 26400 gactgcaata gtgcaatcta aggctctcaa agcataaaac aagtaataag gaattcattc 26460 agatattttc cgaggtggtt atacctgtct tttaaaaaaa aaattttgtt atatattggg 26520 ttaaaaaaag cagaggtgct gggcacagtg gctcatgcct ataaccccta cactttggga 26580 ggccaaggca ggaggattgc ttgagcccag gagtttgaga ccagccatag taagaccccc 26640 atctctacaa aaaaatttaa aaattagcca ggtgtctgtg gtcccagcta ctcaggaggc 26700 ctaggttttg ggcccgagag gttgaggctg cagtgagcct tgatcacacc attgcactcc 26760 agcctgggca acagggcaaa accctgtctc aaacagacaa acaaacaaac aaaaggcaga 26820 ggtaggttaa gctatttatt aatggtcttc tactggtata gatataagct agaaataaca 26880 ttcaagtgtt tttactttta ctacagttat ctggccactt tgggactcat tatactgaat 26940 tagtttcaca gaggaggtaa aatctgttgt ttatgattac atattaactc taccatttta 27000 ccttcagcat tgctgtagta tgtcatatct gaaggcaatt agcacaagtg acttgaagaa 27060 ttgtagtttt gatgacttat atgtatttta taaaaggcag gcagagtttt tgtgtttgct 27120 ttcccctcct ctggacactt taaatttttg ctaccacagg tttccaacaa tttgattatg 27180 atgtgccctt gtgtaatgtg gttggtgttt atttggcttg gagttcgttg aatttttttg 27240 atctgtgtgg gcttatacct ttaatcaaat ttgaaaaatg tcttcagatc ctttttcctc 27300 ccatcctgtt attcttttct ctttctggga ctcttagtac acacaagttt gattgcttga 27360 tactgtgtca caggccactg aggctctttc ctttcagtct tttcttcttt cttccttttt 27420 ttctttctgt gcttcatttt gaatagcttg aatagttttg tttcctgtct tcaagttcac 27480 ttatattttt ttcttctgta gtgtctggtc tgtttatacc atcctgtgaa tttctttttt 27540 agatactaca tattttgttt atctctagaa gtcccatttg gttcttaatt tttttttcca 27600 ttttggctct cattattcat gtttctttca aaattcttga acatatttag catattttta 27660 atagctgttt taatgtactt gtctgttaat tccattattc tagggttttt ttctttctat 27720 tggatgattt ttctcctgat tatgggttat attttcctgt ttattcctac agctgttaat 27780 tttttttttt ttaattaggc attgtgatct tactttgtgg aatgttagat tttattgttt 27840 tcctttaaag aaaggaactt tgtcagacat ctaagttacc tgaagatcaa ctttatgttt 27900 tgaagcttgt tttcaagctt gatcagggaa agtctacgtt tgcctttagt ctaaaggtaa 27960 tttagcccta taataagatg tgacccttct ggagtctttg tagactgcct ctggtgatca 28020 acgatctctt ctctgacttt tcagaacgtt aatgcctctt acctttgtgt aagtccgtcc 28080 taagaatcat tcagcttatg gttgtttgcc cagccccata gagttttagt ctatgcatgc 28140 ttgtcttcgt attctgcaaa gaccaaagga gtcccttagg gagatttctg gagctctttt 28200 cctgcctagc ttcctcctct ccagaactct gccccgtgag ttccaggtcc ttcagcttcc 28260 agggctctga actctgtctc cccaactcag tgctctcctt gggattcttc tccctgttct 28320 gttgtctgca atgggtccca ggaagaatgt ggggcaactg taaggttcac ccttcatttc 28380 ccttccctta gagatcatag tcctgtactg cctgttgtct agtatctgaa acagttgttt 28440 tatatgtttt gtccaagttt agatttgttt gtggtgggag ggtgagtctg gcctcccttg 28500 ttatatcatg ttggcctgaa gcagaagctg agtttctttt attttttaaa tatagtttca 28560 atttttaaca actattaaat aggcaagtat caacaacaat agataacaat ataatagata 28620 tgcatattcc tcccacttta tcaaatctta attttcttca attttttttt ttttttttaa 28680 tagggtctca ctctgttgct cgtgctggag tgacagtggt gtgatcttgg ttcgctgcaa 28740 cctccgcctc ttgggctcaa gtgatcctcc tgcctcagcc tcctgagtag ctgggactac 28800 aggcatgcac catcatgccc agataattta tatatatatt tttttataga gatggggttt 28860 ttgccatgtt gcccaggcgg tctcaaattc ctggactcaa gcaatctgcc tgccttggcc 28920 ccccaaagtg ctgggattac aggcgtgaac cactgcgcct ggcctgtttt cttcagttct 28980 ttattaagaa atgaaacagt aaaatacagc tgaagccccg tgtttgttct ttctgattct 29040 ccctctgtgc ccctctgaga taacttctat gagttttgtg catttttttt tctttttaat 29100 aaaaacaggg tcttgctctg ttatccaggc tggagtgcgg tggcgagatc atactcaatg 29160 cagcctcaac cttatgggct cgagtgatcc tttcgcctca gcctctcaag tagctacaac 29220 tactggtgtg tgctgccatg cctggctaat tttttattta tagtttttaa agacagggtc 29280 tcactatgtt gcccaggcta gttttgaact cctggcttct agtgatcctc ctgccttggt 29340 ctcttactta aagcactggg attacaggtg tgagccactg gctgctcaca tgttttttat 29400 aatagtactt aataatttta tgtctgaaaa tattatataa tgttattttg cccatttaaa 29460 aactttaaaa aatgctaaca aactgtgtac tctgtaactt gtctttttta ctcaacacta 29520 cgtttttgag aatttttctt gttgatctgt gtagttccat tttaactgtt atatcttact 29580 atgtttcatt atgcaacagt tggttcaatc cattctcttg ttaatggaaa tttagtttgt 29640 ttctaatttt tgccagtagg aacagtgttg caatgcatat tcttaaacat gtctgtacac 29700 atctgagggt ttcatttatt tgtgacaaaa cttgccaggt catagtgttt atgcaccttc 29760 aactagatat tgtcgttgtc aaagtttttt tccaaaagga ttttaccaat ttatacatga 29820 accaccgata gatatcctct taacacgtgg tattctgaaa cttaattttt accaatcaga 29880 tagatgtgaa atcacgtaga cttagtttgc atttctttga cttctagtga gaagtagtgt 29940 cttcacatat tttttggatt tttaaaattt attttttatt tttgtttttc ttagagacag 30000 ggtcttgaac ttttacccag gctgaagtgc agtgatgcga tcatagctca cgctaacctc 30060 gaactcctgg actcaagtga tcctcctgcc tcagcttcct gagtagctgg gactacaggt 30120 gtgtgccacc aagcccagct aatttttaat tttttttttt gtagagacat gctgtgttgc 30180 acaggttggt cttaaactcc tagtctcaag cagtcctcct gccttgactt tccaaagtgc 30240 tgggattaca ggggtaaacc accatacctg gccatatctt ttggatttat tggtcatttg 30300 gattttcttt tgggaattac ctgttcatat ttttctccat ttttctgctg aataatttgt 30360 cttttcttac ttatttttca agaaatttta catattttct ggctgttcat tgtcagttgt 30420 atgtgctcca gataacttga acagtctgtg gttgcctttt aatttttgaa ttatgtcttt 30480 agttatgcag aagtttaaaa ttttaacata aattaattta cactattttt ctcactttag 30540 catgagtcta tcagatgggg atgtggtggg atttgacatg gagtggccac cattatacaa 30600 tagagggaaa cttggcaaag ttgcactaat tcagttgtgt gtttctgaga gcaaatgtta 30660 cttgttccac gtttcttcca tgtcaggttg gtatctctac atttcatttt tatatggctg 30720 ataattgtaa tatgtcaact ttatccctat aaaattaagt tcttttatta gctggccgtt 30780 ctctcattat ctcaaattta tttaagtatt tatgttctac ctgattcact cacattcctt 30840 gttttattta attttcacaa catacctgtg aggcattgac attttttctg ttttagagaa 30900 gagaaaactg aaattttaag aggctaaatg accaggatat gtactgctat tgctagcagg 30960 agtggcattc aaactgatta ttttttcttg tcatttatca atcaggactg tttgctttag 31020 ttaagaaata ctcaaggtca atgtgtttct gaatttaaaa ttactgttaa atacaaattt 31080 acacataaac atggtatgta taagaagtag gacataaatc catcatactt gacagaactt 31140 atggaaataa caagaaaatg ttacagtttt tccccaggga ttaaaaatgt tgcttgaaaa 31200 taaagcagtt aaaaaggcag gtgtaggaat tgaaggagat cagtggaaac ttctacgtga 31260 ctttgatatc aaattgaaga attttgtgga gttgacagat gttgccaata aaaaggtaaa 31320 agcaatatat atataatttt catgatgaag attattttgt gttacacaga atgtactttc 31380 tatctgaatg ttagattttt ttttgaaaaa gcttgttata taatgttttt gtagcaataa 31440 aaaagttcca agtgaatgtt ctttaatgaa aacctttatt tatttattta tttttaactt 31500 ttgtttcaag atcggggtac atgtgcatgt ttgttacaca ggtaaacttg tgtcatgggg 31560 gtttatcata cagattattt tatcacccgg gtattaagcc tggtacccat tagttatttt 31620 tcctgatttt cttcctccct cctcccaccc tccacctccc acagtgtgtg ttgttcccct 31680 ctgtgtgtcc atgttttctt atcatttagc tcccacttat aagtgagaac atatggtatt 31740 tggttttctg ttcctgcgtt agtttgctaa ggataatggc ctccagtgcc atccatgtcc 31800 ctgcaaagga catgatctta tttatttttt ttatggctgc atagtattcc atggtgtata 31860 tgtaccacat tttttttaat gcagtctatc attgatgggc atttaggctg attccatgtc 31920 tttgctattg ttaaatagtg ctgcagtgaa catatgcgtg catgtgtctt tgtaacagaa 31980 tgatttatat tccttttggt atatacccag taatgggatt gctggggcaa atggtatttc 32040 tttctttagg tctttgagga attgctacac agttttccac aatggaaagc ctttagttct 32100 aatccatgtc ttggcataga gtttcttttc tttttttttt tttttttgag gtggagtttc 32160 gctcttgttg cccaggctgg agtggaatgg tgtgatctca gctcactgca acctccacct 32220 cctgggttta agtggttctc ctgcctcagg ctcctgagta gctggggtta caggcatgca 32280 ccaccatgcc tagctaattt tgtattttta gtagagacgg ggtttctcca tcttggtcag 32340 gctgatctcg aactcctgac ctcagataat ctgcctgcct cggcctccca aagtgctgag 32400 attgcaggcg tgagccaccg cacctggccg gcagacagtt tctttttttc tttttgagac 32460 agagtcttgc tctgtcgccc aggctggagt gcagtggtgc aatcttggct cactgaaacc 32520 tctgcctcct gggttcaagc gattctcctg cctcagcctc ccgagtagct ggcactacag 32580 gcgtgccacc acacccagct aattttttgt atttttttta gtagagacga ggtttcaccg 32640 tgttagccag gatggtcttg atctcctgac ctcatgatcc acctgcctcg gtctcccaaa 32700 gtgctgggat tacatacagt ttctttaagc aagccttctc ttttccttcc tcccagttct 32760 tggtactctt tcactttcat atatttgcaa atgtaaaatt gtgttttagg tgtatatttt 32820 taatccatgt ataccagtaa cttaaaaaaa aatttttttt tttttaaggg agagcataat 32880 ggagctcttg tgatacggtg ctcttagtgg aagtttggct atcaattcca tcacctgtat 32940 ttcacatatt ttattaatga agttcttaaa ttaaattctc atatttagcc aagtattcat 33000 ttggctggga ggtagaaagc ctactaacca actttttttc atgaacaata tttttaaagt 33060 ccaagatttt taatacctac attagggaaa ttctagaatt aaattcttac aatgtggact 33120 gcatatgagg cttttagtga cagggaattt gttgaaggct atctgtgggt tgtattttgg 33180 tataacattt cctaatttta tttgtggtat gttcatttga tatcatttgg taatacctga 33240 aaacaggaac tgattttact gtgttgcttt ttcatcattt ctagctgaaa tgcacagaga 33300 cctggagcct taacagtctg gttaaacacc tcttaggtaa acagctcctg aaagacaagt 33360 ctatccgctg tagcaattgg agtaaatttc ctctcactga ggaccagaaa ctgtatgcag 33420 ccactgatgc ttatgtacgt gcttaaagat ctttagaaat tgtgatgtgt tttaaaaaca 33480 ttattataaa tgactttaga aaaattttat tatagtagtg gcagaaactc taccaaaata 33540 ttttatatca atttggcatt gaaaaatgct taggaagaca tttagtgaaa ctattcattt 33600 tcgatattaa ttagcaagta ccaatcaaca gattgttcaa tgctagttta ttttcattgt 33660 catgaagcca aattaatgtc taatttgtat gttaaaaaat gtgaacttgc tgaaaacatg 33720 aaaggctaat aaatccaggc tgagcaagca taaatagtac tgatgatgga tttgatatat 33780 aaacaattca gaatgaaaat aattatagta cagtttctat tttaaaactg gccttatttc 33840 ttatatataa aatgtggtga aattttagaa aaattgcctc caaatttagc ttgttgctgc 33900 cattagatat atttttatat ttacatgttt gtatgtagtg aaatctgggc ttatctttat 33960 atatagcact attgtgtgtt ttttaagaaa tgtattttat tccacagtga atttgttttc 34020 tcctaactca tgctttcatt tgtagatgaa tattttattg tttctccttt gcatctatca 34080 aaggaatgga aactcctttg aattgtaacc agcaaacaat tcacttttgt tagggaaatt 34140 ggatgataat tttcctttaa aagataccgc caaacttgag actaacattc tcagctgatt 34200 taagtaggat ttctcttact agattgcatt ttgttagatt ccattttaag ttattttatt 34260 tggatattgt gtgtaatatt gagtgtgaaa aagtgaaaac aaacttttaa ggctcaggca 34320 cctttctcaa ttttcacaat tggtatgatt attaaatgag gacatattga tatttgtgtc 34380 acataatagg ttgaattcca tgtttgggtg ctttgtgaat cattctcttc gatttttctg 34440 aagatgggac ttactgtttt atttcggtga tctttagcat actttttaaa tttttctgtt 34500 tttttatagg ctggttttat tatttaccga aatttagaga ttttggatga tactgtgcaa 34560 aggtttgcta taaataaagg tatgttaaga tccataaata aaatgtgaat tcactctttt 34620 gtgaggttta tctccaaaaa aggcaatatt cacatatttg caaagcattt agtactataa 34680 cttcttgaat gtctgagcag tcctgacatt agggtgggat ccatcagggc ccaagatgag 34740 tgtttcatct ttgttacttg tggcaaagca gcccttactt cttttacttt gtagcattgc 34800 tatgtatttg gcttctagag ttggggcttt gtggctttct tattgcagtg acacaaccag 34860 ctttctccta gtctggagat tatacatcct tgctataagt atttaaaatg ctttctatat 34920 aatgctttaa aacatgtaag atggcttatc cccaagatgg tagctaataa acactaagtg 34980 ataaagtagg taaagatcta tttattcatt tattaaatat tgttggtcat tttacagtgc 35040 tttctaacat actgatttac atttctaatt ttcttctgtc atttttctcc aaaaataatg 35100 gtcatgtcat ccaacctcag tgctgttttt agaggtcttg ataagccagt gagagcagaa 35160 ggagccacgt agtagagtgg gtgagcccag gctttttgtt gcacagacca atgtgaatcc 35220 cagccatgtg acctgggatg tacctgtttc tccaaacatg gaatgtagat actagcataa 35280 tgtccgtttt accgttttat agaataattg tgaagactta aagggacaaa ctattcgaag 35340 catctgtatt gatataaagt tatcactatt ctcgtagctt ccttttggag attttaaatg 35400 attgtgtttg ttaagatgtt aattaaatta ggccattttg ctaaatgctc ttaaaaatat 35460 ggcatgactg cctcatataa aatgatatga tattctttat aattgtcgtt gagcctctgt 35520 gggtggcagg ccctccttta tatgttaagg tagaagagtc tttattctta cttctcctcc 35580 ctggagagcc acttcctatg aatgcctgct ggttctctgt agtcagaggt cttgtggctg 35640 taacttagag tcagtctcca tatccctggg ttctgcatct gtggattcaa ccaaccacag 35700 attgagaaca ttcaagccaa aaaaaaaaat tcacagtttt aaaaaaggaa aagttgaatt 35760 tcttgcatgg agtaccacat tgaatctata tgaatgaagt gatgcgtagg cattttataa 35820 ggtattataa gaaatccgga gatgatttaa agtatacagg acaatgtgta tagattatat 35880 gcaaatattg cagcatttta tataagagac ttgatcatct atggatttga tatcagtggg 35940 agggaggttc ctggaaccaa tccctcaagg atacagagga atgactgtat gttaattaac 36000 tgaggcaggt gatcggtttt ttaagctgat tagggaaaca gtatataaga acttacttaa 36060 ctcataataa aactaaaatt caacagggga gagttatgat tttttggctt tatggttgtg 36120 gaattgcatg taggttacat gtacaatttt gttacatgtg caattttgat gaaaatgctt 36180 ccaaggaatg tttatgatat ttttcactaa agtaacatat attaataaca cagtactgga 36240 agtcctggta tctgtgtact tgtcattgta atgctacatt atttgacctt cacttttttt 36300 cccctttatt acattatatg tgtgagtata ttgtgacatc ttgactcaga ttccagtgaa 36360 ttgtattagg ttggtgcaaa aataattgtg gttttggtaa tttttaatgg caaaaaccac 36420 aattactttt gcaccaacct aataactaag attaccatct ttttttcctt ccttcctccc 36480 ttccttcctt tctgttattc agccagaagt atcagcatca ctgttctctt attttcttca 36540 tgtacatatg gatgatattt tcgaatgacc acttttctct tttgcttttt attattagac 36600 tgtttttttc ttcttgttaa aggataaaaa gattagaaca taaaaggata tttacacatt 36660 gtttccccat tgacttattc ccaagatggt agctaaaaac accaaatgat atagtagtta 36720 aagatacatt gactcattta ttaaatattg ttgagcattt tacgatatgg gaataccgta 36780 gtgaacaagc caggcatact ctgtttcctg aggggcctac agttttattg gggatataga 36840 tgagtgaaga aagcaattgc agtgtaggga gatgagtctt atgtcatggg aaaacaaggt 36900 gctgtagttg acacaccgag aggcatctga cacattgggg gaaatattct agaatatttc 36960 ctggagaaag tgcaggtaaa agccagacct gaaacctgag caagagttag ctaaggccag 37020 gtgcagtggc tcacgcctgt aatcctagca ctttgggagg ccgaggtggg tggatcacct 37080 gaggtcagga gtttgagacc agcctggcca aaatggtgaa acaccatctc tactaaaaat 37140 acaaaaaatt agctgagtgt ggtgacgggc acctgtaatc ccagcttctt gggaggctga 37200 ggcaggagaa tcgctttaat ctgggaggtg gaggttgtag tgagctgaga ttgcaccatt 37260 gcactccagc ctgcacaaga gcgagactct gtctcagaaa aaaaaaaaaa aaaaagttag 37320 ctagctgaag agtataggaa agaatgggta caggaaatta caggtgccaa gttacagagg 37380 tgagagaaat tatggtatct ataggtaatt gaaagtaatt cagtatagtg aacattgaat 37440 agggctgggc ggatgaaggc aaagcagaaa aaggaaagca gatgggccat ggtaaggagt 37500 ttatatctcc tcccaagagc aatcgaagtg actgagagtt ttaaacacag cagtgaagtg 37560 aattacatta aaaaaataag aacttgggct ctagaataaa aaacggatat aggaggaagg 37620 caggagtcac agtaggaata tcttttggga ggctgtgaca ataatccaag tgagaagtaa 37680 tggcaacttg agtcggttaa ttgtgttgag aatggagaga agttgacagg ttcaaaattc 37740 atttttcttc tttttttgag tctcactctg tcacccaggc tggagtgcag tgatgcgatc 37800 ttggcttacc gcagcttcca cctcctgggt tcaagtgatt atcctgcctc agcctcctga 37860 gtaactggga ttacaggtgc ctgccaccac gcccagctaa tttttgtgtg tttagtggag 37920 atgtggtttc gccatgttgg ccaggctggt ctcgaactcc tggtctcaag tcttccgccc 37980 acctcagcct cccaaagtgc tagaattata ggcatgagct accacacctg acctcaaaat 38040 acatttaata gagcaagcat gagccactat gcccagcctc aaaatacatt taataaacca 38100 atggaatttg aggtaatgat gaaagacaca tgtcaaggat cattcctgtg ttgttggcat 38160 aagcaacagg gatgaaaagc attgaggaag agcaagattt tgggatgcgt tgtcacacag 38220 ttgattttag gtatgttaag ggagggagac ctgtaagaca gcaaagtgga ggtggtgcaa 38280 gaattagttg tgttggctgt agcacagagg acagtttgag ttaagagagt tgggactgag 38340 aatcccgagg aactcttagt gttgaacatt tgcgtggagg aggggacacc aaaggagttg 38400 ccatagacat cgaggaaatt aggaggtgtg gtgtgcagaa agccaagtga agaacatgtt 38460 ttaagtagga ggatgctatc aactgtttta aattctgctg agagtttgag aaactgagga 38520 cttagaattc atcattagat ttggcaatgc gccaatcatt tgtaatcttt taaacaatag 38580 ttttgctgta ctgggtagca aaagagtgat ttgaggagtg gtcatttgga gcatatgcta 38640 ttcaaacaga gaagagtcca cgggctttgg taacatgaag gtcctataac catagcaaga 38700 gaatgaggtg ggtggaagtc atattaacgt gaatagagga gtaggttaga tctgaggaat 38760 gtgggaacag agacagggtc tcattatgtt gcccagcctg gctcagactc gtggcctcaa 38820 gcgatcctcc tgcctcagcc tcctgaatac ctcgggtttc aggcctctgc atctggcttg 38880 aaaacaacat tttctcagaa gcttgtttta gttgttttag aaataacgaa ggcatgtgta 38940 aacaactgtt ctagaagctt agtttggaaa gggaacgttt attgatgcat ataacactta 39000 tatgttgggt gcttatgtgt caggcactgt tagagttgct cgggaaaatt tacaaaccaa 39060 gcaaaccatg ccccttcatt tcctttgggt gaagtgaggg agccatgtgg ttatctgaag 39120 gaagagctta gcaggattag agggaagaaa gtgcaaagcc tcctagggtg attggctggc 39180 tcttttggag gaacagtacc tataactgaa tgaaatgagt gagggtaaga gtggcaggaa 39240 atgaggctag aaaaggagct tgggccatat cacgtagggc ctcgtaggct gtgaatctga 39300 cttcatttct tattaatgaa aataaatacg atgatgggtg atgggaaacc catagaggat 39360 ttggagcaga agaatgatat aattaaaatt ttattttaga aatatttttc tggttgtcgt 39420 aagaggaaaa atatttagcc ccagggcatt ttggcagaga gttaggaggc tattgtaaca 39480 gcccaagcaa tagacaataa ttgtttggat taggcgggta gcaatagagg tgatgagaag 39540 tcgtagcttc tgtaggtatt tggaagatat atattgtgaa ggatttgctg atgaattccc 39600 tgtaaggggt gagatgtaaa gattcataga acattaagat attttggtca gatcatctga 39660 tcaatggaaa ggtcagttat agtggacaga ttatgagaag aacaggtttg ggtgagaaaa 39720 ctttagattt cagtgttgga tatcctaagt tttagatgat tattgatatc caagagatat 39780 caatatttgg gatcaatttg ggaaatatga tcccaaagtt caaggttgag gttggagatg 39840 taattcagat ccgatggtag ttaaagcagt gagactgaat gagataaaat agggagtgaa 39900 tgaaataaag agtaggtgtg atattgacct caagggcaca ccagcattta gaggttggga 39960 agatgaggag agagcagcaa agaggactgg gagggccact aatgaaggag ggaagtacag 40020 gaggtgttta gttctgaagc cacctgaaga aaatgtttgg aataggaaga agttgtcagt 40080 tgctttaaat cattcgggga ggttgagtga gatgagagtc tagaactaac agttaggttt 40140 gatggtgtgg aggccatcag taaccttttc tttctttttt ttttttgaga cagagtcttg 40200 ctcagtcacc caggctggag tgcagtggcg cgatctctgc tcactgcaag ctccgcctcc 40260 caggttcaca ctattctcct gcctcagcct ccggagtagc tgggactacg ggtgcccgcc 40320 accatgcccg gctaattttt tttttttttt gtatttttag tagagacggg gtttcaccat 40380 gttagccagg ttggtctcga tctcctgacc tcgtgatcca cccgcctcgg cctcccaaag 40440 tgctgggatt acaggtgtga gccaccgcgc ccggcccaag agtaaccttt tcaaaagcag 40500 ctttgctcta ctgatttggg taaaagctta gttgcagttg gtttgggagg aaatgggagc 40560 agaaaatttg agagagtgag tgtagacaac tctttcaagg aatttcgcta taaatgggag 40620 tagagatctg aagactgaat aattagcaaa ctgaaaagtg ggaagacgta attctcttat 40680 tatttcattt ttcttagtga aataagaggt gaagttctct gagtaatagg agggtcaaac 40740 aggtgttaga agttcacaaa gaaaggaaga ggtttgaaat agtcattttg agagtgggaa 40800 atgtagaaga attaacagtc attgctgagg gtgcgtttga aatctgtcat gagtttaaaa 40860 taacttgtgt catcatcgat gtgtttattt tcaactatat tcaactgctt gggtgtaggc 40920 atcaggtagg taaaaaaagt gggttttatt atgagtagag gttttgccac gtaattacca 40980 tggagggagg gaagagcaaa ggagttgaga gtatagatac aaaggaatga ttactgtaat 41040 gtgggtaaga gaggaatgga aggctcagtg ggcagtggga gtagggatgt tgataggtaa 41100 ggaaaaggtg ataggatcaa tgcatttggt tctgcaagtg tcaaagtatt gttggggaaa 41160 gcatgctgga aggaaagata gggatgctgg tgttctcagg gtggaaggct tacagttgta 41220 gtctggaagt ggtgatttta ttggcaatta taaggtcaac ggtatgacta tggaattgag 41280 tggctaaggt ctgttgaaga aaagattgtc ggaaatgcag gggtcaagga actggcctgt 41340 ggatgttgaa ctcactggca gtgatcaagg aatagtagtg gagtgaaagt agttaatgaa 41400 tcaggcacta agatctccaa gggatgaaag gatgcagttt ggagatgaca agataactgt 41460 agtaatcagg aatagcaggt tttgtagctc tgtctcatag gcctcagagg agatgggctt 41520 ttgaaggaca agagaaatga tgatgaataa attctaagca ggggaagtgt ttgggaaagc 41580 agggcaggct ttgtgctgtt gatggcaaat gatgtaccag acaggatgaa gttgagaatt 41640 tggaagttga tcactgatta gaaaggctta cattttattt tggccggggg tggcagctca 41700 tgcctgtaat cccagcactt tgggaggcca aggtgggcgg atcccttagg ccagaagttg 41760 gagaccagcc tggccaccat tgcgaaacac tgtctctact agaaatacaa aaaaaaaaaa 41820 aattagctgg tcgtggtggc acatgcctgt agtcccagct actccggggg ctagggaatg 41880 agaatagctt gaagccggga ggtggaggtt gcagtgagcc gagattgcgc cactgcattc 41940 cagcctgggt gacagagtga gactctgtct caaaaaaaaa aaaaaggaag ggcttacatt 42000 ttattttggt gctgactggg aatgaaggca atgagggatg actgttggag aaggctgtgc 42060 ttactaaaca gtattattaa gtagcagcat acatggtgtt atactgactt ctgattttgc 42120 aatagtacag acaggttcag attctcattt ccaccttctc cttctgccta ggtgaataac 42180 tgctgggtta tagtacagat gactgcagat catttggaat ttactttaaa tgtaaacagt 42240 aaaaatttga aagagaggga aagtgattga ggcaatttgg ggattgaata agaaggtctt 42300 tttgttggaa ttcatttaag gaaagaaaat gaaaatttga tccctaatat tatttaatga 42360 agtggctaaa tgaatatctc tgctttgtgg tttgaaaatt aatattgatt ttttttcccc 42420 ctagaggaag aaatcctact tagcgacatg aacaaacagt tgacttcaat ctctgaggaa 42480 gtgatggatc tggctaagca tcttcctcat gctttcagta aattggaaaa cccacggagg 42540 ttaaatatta cctttttttt ttttaactta aatcaattct gtttattttt ttatcacatt 42600 ttcctatatg tgaagaatac tattcattaa ggctgactca tagaaatttg cttgaataca 42660 cacacacaga ctgatgcata aatttgagaa atatctttcc agttgttgaa tagtgaatcc 42720 aaaggtttaa gccttttctg tctgctttgt aggatgtttt atgaaacaaa ggaatagaaa 42780 ttgtattcat attatacatt ttgaaattat atctatatta tattttttgt caaagcaaaa 42840 taaattatac attaaggaaa atatttaaga ttcaaagttg tcattttctt tctgttaatg 42900 agtatctttg atttaataac atttatagtt tggtcacttg aaatctatag tgaccaaaag 42960 caatgtcata tttagtagcc tcatttctgt tactatctga ttattactta agaattctac 43020 ttaattaata gattattaga acaaaaggca ttccaatttt agagattctt ttatggttaa 43080 agcactaggt aacttaaaaa atttggatca aatgttatac agattaatag accttggaat 43140 acaggggcta tgtctttttg gaatcagacc ttgtcctggc cttaattgca ggatgacttc 43200 cttattaaat ctctaaaagc aggaatgctc tggaacaatg aacaattaga atgtggtaat 43260 gtaattttgg gccaaaaaat actttgtaga aatgtgattc tcttacttgg aatagaaaga 43320 attctgactc gaaaaagtgc agttaatgta tgcttttctg ggtaagattt gtgatagatt 43380 ttgattgaga tttaaaacca tgatatataa atttagcttt tttgtcaaag taatttgcca 43440 ccctagaatt tgtgttggta atttttaatg caacttggac aatttctgaa agatgtaact 43500 ttcttttttt tgagacgagt ctcgctttgt tgcccaggct ggagtgcagt gacatgatct 43560 caggtcactg caagctccgc ctcccgggtt cacaccatta tcctgcctca gcctcccgag 43620 tagctgggac taccggcgcc cgccacccca cctggctaat ttttttttta tttttagtag 43680 agacggggtt tcaccgtgtt agccaggatc gtctcgatct ccggacctcg tgatctgccc 43740 gcctcagcct cccaaagtgc tgggattaca ggcgttagcc accgcgccca gcctgaaaga 43800 tgaactttaa aatggggaag gatactagta aagccatttc ttactcatgt atacattttt 43860 ccctccatga aattagagca gccacctttt acatgacttt tacatgcatt tcagattttt 43920 gtactagcaa ttaaaatatc tactggatgt aaatcacatg tgcttaatgc tttgcttcat 43980 aatatctgtt gaagtcaatt aaaatataga gacagatctt taaattgaac atgttttatt 44040 tgggaagcaa gaattaaatt tgaggcatat acacagactg ggtgtccttg gtatctctga 44100 agaacaaaga gaagtttgga ggttatagaa aaaggaaaat gtgacattgt ttttccagaa 44160 agttctttgg cactagtaaa ttttggggag ttggaagctc tgatgggtta gtgactgtgg 44220 tgggtaaaac tagtcttaga gtcacaacag gttgtttcag tatctattag ataaaacagg 44280 ttttaggtta caataggcag tttcagcagc taggcttgca gaaaattaca ttcttagagt 44340 aatgttatgt gccttgagtg cttttttccc cttggccctt gactctgatt tagttgggta 44400 tgacaagaat tatcaattta tataattact ttttacatat tgaagctgaa taggttttct 44460 taaaacttgg aaatgggaaa tactgggtct tgtgaagttt tagtgtgaaa acgataacta 44520 gtctcttatt tcatgctctt tgtaacaagt ctacagtaat acctaatgta tctagatgac 44580 acctcagaac caggagggaa caaaaaagac ctctgagcag tcaaaataat gctataagca 44640 tgtattccag cttactttcg gcatttctgt ggagtgcagg aggccacatt ttgttcatag 44700 atccagtttg acaagcttgg gtactgagtt aaagtgaaaa tggtgtaaat aagtaatcat 44760 attcacatga cagtaggtgg aagtgacagc tgacaatctg aaagagtgga caaaactata 44820 aaaattagaa ctaagaactc ttaaaataga acggtttgaa gtttgttaca gaagggagca 44880 gctttatgct tcagtggact ctgaaggtat tggcagtgta tagtactgct tagtcattga 44940 tttaaattcg gtatatatct cttctattgc tgtcatgtac ttgacattct gctgggtgct 45000 aaggctgtct gcaggctact aatatgcata ataacaatcc tgaaaaagaa ggaaaagtat 45060 actgtgcctt actgaagaag gcaggacagc cgttggtatt tgttagagta aatattagtt 45120 atcttacata aagcatgtta tattccctga tgtcagggcc tgataaatga gcccttacac 45180 tcttgatagt caatctgtgc cactgttgct gtgtttgtat gttacaccat ttcctgtcca 45240 tgtaacagtt aaactgtatc acatatctgt tcctactaaa ctatttgcat ataattttaa 45300 catttgagtg gctgtatata aagctaaaag ttctttataa gatttatagc atcttagaat 45360 gtttaaatta gataacatta gtgtgctttt agtttttgaa tttaattttg ctcttgattt 45420 tgtttgtgtt aatgtagact ttgtctacgt aagcttgagc ccaactttgg agtggtgttt 45480 tcagtgatgg aagtaactgg aaataactca tgaaaccact tagtactttt gatagtttat 45540 tcccatgaag gatcaaattt ttacttgagt cattaatata aaaatttaaa agacatgtca 45600 gattttatta agcatggatt ttaaatatat aaatattaga agacctaaac aaaatcgcta 45660 atgaaagagt aaaacatgtc cctgcctatc atactccctt cactttcact gatttctgct 45720 tttatgaagt actttaataa gctctacaac aaataaacaa gacattgtgc ctcattttac 45780 actctagcag tggttttcca ttccaactaa ctagattggg tttataatat agtcatttaa 45840 acttacttag ttaaaatgtt atacattagc aactgcaatt aaggagctaa gaaattcagc 45900 tcgtatttat ttatatgcat cttatccata gtttctcact tgttatattt gcctactgat 45960 ggcaaattga ttttttctgt tccaaaaatg tagtgttttg agatttttgg agatgcaaaa 46020 cagcatcatt ttcaaattag atcacaaaca atcttacttg ttgcagttga gactagtaat 46080 tgatcagtga ggtgaaaaaa ttaggcaaaa cggtatcatc aaaattttct ttcttttttt 46140 ttttgaaaca gagtattgct cttgtcgccc aggctggagt gcaatggcac gatctcagct 46200 cagctcactg gggcccctac ctacgggatt caagggattc tcctgcctca gcctcctgag 46260 tagctgagat tacaggcgca tgccaccaag cccagctaat ttttgtattt ttagtagaga 46320 cagggttttg ccatgttggc caggctggtc tggaacttca gacctcaagt gattcacctg 46380 cctcagcctc ccaaagtgct gggattacag gcatgaacca ccgtgcccgc cccaaatttt 46440 cttttaactt aaagtgttaa tgtttgtttg ttcccaatat ttttatatat gtcaaggctt 46500 tttcattata tacaggccag ctctttggag ttctgcatag tgtttcttgt ttaaaccaca 46560 cctataatgt accatctaca atttccaatt ctttaagaca gagtgaaaaa ttaagacacc 46620 tgaagcaatc tgagtgcgga gtcctaggca ttatgatttt ccttgacact tttagggttc 46680 ttttatcaca gtttatcaaa cacctttttt tttttaacaa aaaacaaatt tacaaaatct 46740 ttccatgtat tcaacttaga atttaatgaa atagggtttt tttttttttg gtggtcatgt 46800 atcatcaact ttctttacat ttaattaaat taatcaacaa aaaacatata gttgacataa 46860 acaaatttgg gaccaagcac tactgactct tagtaaacat acaagtcaac tgttggtgca 46920 gaagtgcctt gatgctagag agtagcctgc aagctgtaat tatatatggg cattagggaa 46980 tgaagaacag ccttaatact attgatcttt taagtgaagg tcagcttaga aagcttttac 47040 ttgttaaaaa gcttcacagt ttgtccttgt agttaatgca attgaagttg aattaatctt 47100 tcttaatttt ttttttaggg tttctatctt actaaaggat atttcagaaa atctatattc 47160 actgaggagg atgataattg ggtctactaa cattgagact gaactgaggc ccagcaataa 47220 tttaaactta ttatcctttg aagattcaac tactggggga gtacaacaga aacaaattag 47280 agaacatgaa gttttaattc acgttgaaga tgaaacatgg gacccaacac ttgatcattt 47340 agctaaacat gatggagaag atgtacttgg aaataaagtg gaacgaaaag aagatggatt 47400 tgaagatgga gtagaagaca acaaattgaa agagaatatg gaaagagctt gtttgatgtc 47460 gttagatatt acagaacatg aactccaaat tttggaacag cagtctcagg aagaatatct 47520 tagtgatatt gcttataaat ctactgaggt actaaataaa gaggaagcac atttttagtt 47580 attagtaggt tctggcagac tttattcccg taaagagaca gatagtaaat attttaggct 47640 ttgtgggaca tacagtctct gttgcagtaa ctcagttctg ttattgtagt gtgaaagcag 47700 ccacagacaa atgtaaacaa atgtgcctgt ctttcaataa aactttatct acaaatacag 47760 atagtgggcc acatttggct tgcgagctgt agtttgctgt tcctgactta gtatgatatg 47820 cagcattgtg tagtggaaag attttatagt atcaacagac atttgtagga gtttgctatt 47880 ttataatttc gtatgctttt ttcataatag atgtctctgc tttttgtgga ttctcttcat 47940 atctactagt gtttactctt ctgactttga tttttggggg tgtattttat ttctttatac 48000 agaatttttt tcttttttct ttcttttttt gagacaaggt tttgctgtgt caccccagct 48060 ggagtgcagt ggtgggatct tggccccctg cggtcttcaa ctcctgggct taagcgatcc 48120 tgtcacctca gcctccctag tagctgggac cacaggcctg caccactaca ctcagctaat 48180 ttttgtattt tttgtagaga tggggtttcg ctctgttgcc cagactggtc tccaactcct 48240 ggactcaagt gatccacctg ccttggcctc ccaaagtgtt ggaattatag gtgtgagtca 48300 ctgtgcctgg cccagaattt ctttacttgc tcatgtgaga gagtttctaa taaactcctg 48360 atgcttttgc ttgacactat agttttactg tcatctcaga gtcagatttt ttccttaatt 48420 tcttcattaa attgatttct taatttctca tttgttttgc attagtttac aaaattactt 48480 aagatgccta tattctctga aattttatat tttatttcac gataaataag tttaaaaaat 48540 tagatttgac catttaatta gagttatttc cccatcattt ttctaatggc aacaataatt 48600 ttagcatttg agcaattctc tgtattttgg taactattag taatcacttt tatcagtata 48660 aacatgcatt tcattttaaa atggttttca aaatattctc ataccaacca ttcataaaag 48720 atgttcccct tctgggaaat atcagttttt gctaacatct gcatttccct ttgattttct 48780 aggaatttct tattaggtat acactttaag tgatatgttt catataatat tataggatta 48840 tcaggatttc atgatttttt ttttttgaga tggaatctat ctctgtcgcc caagctggag 48900 tgccgtggcg cagtcttggc tcactacaac ctctgcctcc ccggttcaag tgattctcct 48960 acctcagcct cccgagtcac tgggattaca ggtgcccgcc accacacccg gctaattttt 49020 gtatttttag tagagaaagt gctgggatta caggtgtgag ccactgcacc tggccttgga 49080 tttcgtgatt tgactgacat cttttacacc aattattgcc atttttttat tgggtactaa 49140 ttattagtat tgctttcttt attcgttaaa taagaagtaa aagaactttt aaaaaataaa 49200 ataacttttt ttcctagtac aaagcttatt ttcaattttt tttattgctt aaattttgca 49260 ggttaattaa ggctgtactt ctttttccta cttcctgttt aaatatttgg cattttttga 49320 gggttttctt tctatggatt tttgtggggg atcccatctc gttggacact tggttcctgg 49380 agattgccaa attattgaaa agtttcctca tacccaaaca ttggcaatag actgaataaa 49440 taacatctct gacattattt ttcaattata tagagaatgc tttttgtaaa atactgattt 49500 atttaaagat attacaatca tagtagtttt ttgcaatctt ttttaaatca gtggatgtca 49560 aggaacaact attgttcttt gtacggcatt tttcaacatt gtgaagagtt cttatactca 49620 aaaagtttgg gagacacagt gtgacattgt ttaacctgag ttgaacttgt cattttgtat 49680 tcttgtttag agcagggatt ttattttgtc tctttatcta actttgtatt cctaactatt 49740 tctttctttc tctttggttc tttgtttctt tgttcattct tctctctctc ccttttttat 49800 ctatcatata aatatgtaaa tatatattat atatccatta gggaagagga agttgtctaa 49860 agatatctag tatataggag ctttgttctg cagaaaagag gatatgaagt caattatatt 49920 ggaaattaat gcttaatact ttttttaaag catttatctc ccaatgataa tgaaaacgat 49980 acgtcctatg taattgagag tgatgaagat ttagaaatgg agatgcttaa ggtatgttta 50040 caattataaa aatattactt caagttcttt ccaaaggaca tttaattaag taaaatatta 50100 actaattcta aactaggttc taccacaatg aaattgctac taattatgta acattagatt 50160 tcacattttc caattcatgt ttctttcatg tagtctataa ataatgggtt agaggtaatt 50220 tactaatttt aaatgtgctt tccttgttcc ttcttatttt ttattttgaa gacagggtct 50280 cactctatca cccaggctgg agtgcagttg ctccatctcg gctcactgca accttcacct 50340 cctgggctca agtgatcctc ctgcataagc ctcccgagta gctgggatta tgggcgtgca 50400 ccaccatgcc cggctaattt ttatagtttt agtagagaca gggtctcacc atgttgtcct 50460 tgctggtctc gaactcttta cctcaagtaa tccacccgcc ttggcctccc aaagtgctgg 50520 gattacaggt gtgagccacc acacctggcc ttggatttca tgatttgact gacatctttt 50580 acacaaatta ttgccatttt tttattgggt accaattatt agtattgttt tctttattcg 50640 ttaaataaga agtaaaataa ctttttttta aaaaaagaac ttttttccta gtaaaaagct 50700 tattttcaat ttttttattg cttaaatttt gcaggttaat taaggctgtg cttccttttc 50760 ctactttctg tttaaatgtt tggcattttt tgagggtttt ctttctatgg atttttgtgg 50820 gggatcccat cttgttggac acttggttcc tggagattgc caaattattg aaaagtttcc 50880 tcatacccaa acattggcag tagactgaat aaataacatc tctgacacta tttttcaatt 50940 atatagagaa tgctatttgt aaaatactga tttatttaaa gatattacag tcagtagttt 51000 tttgcaatct ttttaaaatc agtggatgtc aaaaacagct attgttcttt gtacagcatt 51060 tttcaacatt gtgaagagtt cttatactca aaaagtttgg gagacacagt ttgatattgt 51120 ttaacctgag ttgaacttgt cattttgtat tcttgtttag agcagggatt ttattttgtc 51180 tctttatcta actttgtatt cctatttctt tctttctctt tggttctttg tttctttgtt 51240 cattcttctc tctctccctt ttttatctat catataaata tgtaaatata tattatatat 51300 ccattaggga agaggaagct gtctaaagat atctagtata taggagcttt gttctgcaga 51360 aaagaggata tgaagtcaat tatattggaa attaatgctt aatacttttt tttaaagcat 51420 ttatctccca atgataatga aaacgatacg tcctatgtaa ttgagagtga tgaagattta 51480 gaaatggaga tgcttaaggt atgtttacaa ttataaaaac attacttcaa gttctttcca 51540 aaggacattt aattaagtaa aatattaact aattctaaac caggttccac cacaatgaaa 51600 ttgctactaa ttatgtaaca ttagatttca cattttccaa ttcatgtttc ttttatgtag 51660 tctatgaata atgggttaga ggtaatatac taattttaat tgtgctttct ttgttccttc 51720 tttttttttt ttttattttg agacagggtc tcactctgtc acccaggctg gggtgtagtg 51780 gtgccatctt ggctcactgc aaccttcacc tccagggctg aagtgattct cctgcatgag 51840 cctcctgagt agctgggatt acaggcgtgt gccaccatac ccggcttatt tttgtatttt 51900 ttgtagagat ggggtttcac catgttgccc aggatggtct taaactcctg ggctcaagtg 51960 atctactggc ctcagcctcc cagcgtgctg gggattgcag gtgtgagccg ccgcatccag 52020 ccctgtgttc cttcttgtgt tactttcttg taattttttc ctggaatatg ggtagtgatt 52080 tggctctcca gtattgaaat tgagtttcct ttcttccaat tcatgtgtat ccatttttat 52140 ttggaagttt tgtttttata cattcaataa tcatctttac tttctttggt attatttact 52200 atggatattt tatattatat aattttcaaa tggattaaat ggttcagttt tactcttatt 52260 attgagattg aaaatactag tttataattt atatattttc tattccttta cctctaattt 52320 ctttgtcagg tgttactaac caaagatgta taataagaaa agccaatgta gctaaattaa 52380 gtaaaaaatg aagaaaaaca cagaagttcc ccattatgca tttttttatt cctaatcttt 52440 aggttgatga gattttttta tttttatgaa atgagattaa tttattgact tttttagttt 52500 tgaggccaag taatgagtag tgagtaagaa tgtatattct agggccaggc atggtggctc 52560 actcatgtaa tctcagcact ttgggaggcc gaggcaggag gatcacttca ttccaggagt 52620 ttgagaccaa cctgggcaac atggcaaaac cctctctctc cagaaaaata caagaattgg 52680 ctgggtgtgg tggcatgtgc ctttagtccc agctacttgg gaggctgagg tgggaggatc 52740 acctggggag cctggggagg ttgaggctgc agttagccat gaccatgcca ctgcactcta 52800 gcctgggtga cagagtgaga ccctgtctca attaaaaaat taaaaaaaaa aaagtagatt 52860 gtgaattcag atgtaggttt gtatcccagc ttttccagtt agtatctgtg tgactttggg 52920 gaagtttctt agcatctttg atactcggtt aacagttgta attattattt aaggtattgc 52980 ttgagaagag cttagtatag agcctgacat ttagtaagtg tttaatacat attagctaac 53040 agtaaaacta gaacataaat actgaattgt attttgttat taattatcca tttctctgag 53100 aagtactgtt ccaatagtac atttatagga aacttgtgga cgtctacaaa cgtatacatt 53160 aaatctctta gaaggcaacc tggatgccca tattagagaa ctctatttta aacatgcatt 53220 ctaagtatgt ttgtggactt gaataaaata aaacaaacag aaacacttct ttcttctgcc 53280 ttcaggcttg aaatgaacat actttttttt aaaaaaaaac cttcaaaatg aaaatattaa 53340 ataaaagatt taataaaaag agaaagtaaa aactgtagtt taataaagtc ttcctgtctc 53400 ttcatagtta aaaaatgtta tagatgaaac aattttgaaa tattcttgaa atagataatc 53460 tttatttagg ggagaatgtc agatactgtc aagccaaaat aaaaacaaat aactttattt 53520 catgtttgta aaattccttt tctaaaatga tttgaatctt ttgttgtttt gacaattcca 53580 aaacacattt attgtttgct catagtttca gccttattca gaaagaatgc gactgacaca 53640 tgatatagag aaacttgttc caaaaataac attaaaatcc acgtttacta cttgagaatc 53700 gaaaatattg aggtgcaata aagaataaaa tgttttaaat tatccaaatt taaaatttat 53760 gatagctttc cccaggggca gtttattata tgctattaat gagccttgtt tatgctggaa 53820 atgttccatc tttggccttg cgccttagaa accattcatg agcacatatt taaaccggag 53880 cacacatgtt cttttgtagt atggcttgca catctgccag ctttcgacaa aattgtaggc 53940 cctgttaata atagtccttt tgtgtttggt gaaaaagata cgacactgtc agtggttttg 54000 cttttaagat ttcttttaaa ctttcagtct ttagaaaacc tcaatagtgg cacggtagaa 54060 ccaactcatt ctaaatgctt aaaaatggaa agaaatctgg gtcttcctac taaagaagaa 54120 gaagaagatg atgaaaatga agctaatgaa ggggaagaag atgatgataa gggtaagcac 54180 tgaagtatgt ttgaaatgac tcacctgtga tacctaccac tgactttaac ttaggatcca 54240 gttttggatg gtttggaggt cagggacttt gtggcatata gttaattatt ggatccttat 54300 aagcttttgt ctccttagtg cttttgtctc cataaagcac aatcttacta cttagaaaaa 54360 tagagtaata gcattatgat gataaaaata tctttccctt tgtttttttg tatttctcca 54420 aatcattata gctctcattt agaattatta aagctgagaa ctctaacaat gaacttttat 54480 tgtttagtgg ttaattatct tgattctttg ttttgccctt tcttggccac tcaggaatct 54540 ttcaagctca ctgtggacag ggaaagtgac ttgggtagag ctaacataac ttcattgtgc 54600 tgtgcagtta gaattttgac caaagatgtg ggtaactaac ttttcctaac taaatgacat 54660 ttaggtaact aaactaaacg agattttcgt aactaaattt tggtgtaact acatttagct 54720 ttaggtaact aaaacgaaga ttttatttta tctgtggatt tttttagtgc gggactaatg 54780 taatttctga ttaccattaa ttgaaggttg gttatattat aacatttgga ttggtatatt 54840 gcttgccatg gtttgttcta aatgttagcc tttagaagta ttcctgattc taaaacatca 54900 gtttttttta atagtcctgg caaagtgtga atcacaacaa aattctaata cttaaaagta 54960 atccaagtgt cacagatggt acccagaaga ccagtttgta ttggaattaa aaaatagaaa 55020 acattaaccc atggtagctg tcactgtatt ctttcaaaga agccaatgaa ataaactgtt 55080 ttctccctct atgtggtgtt tttctacttg aacataaatg cacattttat tttatttcca 55140 gactttttgt ggccagcacc caatgaagag caagttactt gcctcaagat gtactttggc 55200 cattccagtt ttaaaccgtg agtataatct catttaatca aatcacatat ttagtattct 55260 ctttaaaaca agggaaaagg caaataacct gtctgcttaa cagcaacagc acaacttcac 55320 tatagttata catgccacac tgtattttct gtgtgactac aaaattattt caaagtgata 55380 tttatataaa attcatttct gcaaattgtt tttataagtg aggaaaaatg gttttccttt 55440 aactgagcag ttctgagtag aaactagttt aaagatactt ataaataaat gttaatttaa 55500 tactgacttg tttttcatta aacgagtgtc tatgtgcctg ttttgtgtat attacccaga 55560 acatgcagat gtactagaag ttcttaatac aacaatttga ggaatagtga taatcttatc 55620 tattttaatg tactcaaaat ttgtttacat ctaacaggca catttttgtg aggattaaat 55680 gagatgaata agaatgagat gaacaagtaa atgtgaataa aactaataag cctgtgaaaa 55740 tctagactgg atttttccta ttctgagaat ttaaaatata atccactgaa gtatttcttt 55800 ccttttttct tttgatctta aacatttttt atttatgtct tacatacaga aaagtgcaca 55860 tgttgtagag atcaatgaat tgtcataaac tgggcaccct gtggccagca cttagttaag 55920 aataggtcag taacagcatg ccagaagacc acctctccaa ttgatttttc ccatgatatt 55980 ttattaagaa aattttctaa gatgtagtaa agttgaaaga acttttttct gtgcatgtct 56040 gtattcccac cacctaaatt caactatcat tactatactt gctttatcac atatccatcc 56100 attcatatgt ctctatccat ccattcattc attccagttt taaaatgcat ctcagggtca 56160 atcgaggaca ccattacact tccacctaag tatttcagca tgtaaattat taacgagtta 56220 aatatttact taacagtttt ttctttggtg taaaatttgc acgtaaggaa atataaaact 56280 ttaagtgtac atttgcaaat tttaaatata catgtgcata cccatgtaac ccaaattctt 56340 atcaagagat attattatca tcaccacaca gagttccctt atttcccttt tcagtcagtc 56400 cttgtccctg agcatttctc ttattatttt aaagtattga ttcttttgga tatctagtat 56460 gaagcttaga atctgttttt tactttagat gtatgtagtg aaatttaata tatataccaa 56520 atggtagttg ttagttagct tgaatgggac attggtcaaa tggcattgtt tgttttaaag 56580 ttccaggttt gtgcatttat gtatgaagtt tgaaaataaa ttctatgaga ggaaatgaaa 56640 aattgaatgg attttaattt gtaccttggg tttcttatta ataaaacaaa atagcttttt 56700 gcttttcacc ttcaagagtt cagtggaaag tgattcattc agtattagaa gaaagaagag 56760 ataatgttgc tgtcatggca actggtaagt tgtacttaag caaaacctaa tcctttaaaa 56820 aaataaaaca taaagagttt gaaatgctta atctttcatt aaactctcaa aatacaaatg 56880 caactacaaa tgatgtaaac tatagaagag agtgaacaaa gaacagatgc tcagatttat 56940 gtatcaatta gcttttagga agatagcata ctagtattga ccattcatct gtataagtac 57000 attgtaaaaa gaaatgaaag catcaaaggt ttatttttat ttctatattt ttttcatttt 57060 atttttatat ttttttcatt tcaaggatat ggaaagagtt tgtgcttcca gtatccacct 57120 gtttatgtag gcaagattgg ccttgttatc tctcccctta tttctctgat ggaagaccaa 57180 gtgctacagc ttaagtaagt catgttatca ttgccacaat atcaccctct ttttttcttc 57240 tgtgggtgaa acatctgatc catcatgcat gttaaaatct agttcacaat aacacatttc 57300 tgcaggtatt gctttatctt tattggtaat aaatgaccct ttagtggaag agcttacctt 57360 ctttcttgtg ttctctgtaa ttcaaagcta ccaggtggcc ctgataaaat ttttttaaaa 57420 aacattatta ctttatgctg gtttacattg aatatctcaa aattcttttc tctttttgtt 57480 acccttgctt tttagcttga taagaagtgt atacatggaa gtatattttt tatctatgaa 57540 acacttttca gcttcttcaa cctgagcttg caatctgttt taaattgata cataatatct 57600 ttacatattc atggggtact gtagtatttt gatacactca tatcaaatac acttgatcaa 57660 atcagggcat ttgttcatca acttgaacat ttatcatttc tttgtgctgg gaacatttct 57720 aatcttttct ttgagttatt ttgaaataca cagtgttgtt gttaactata gttaccctac 57780 tgttggttaa tgagtacaaa catacagtta gaaggaatag gttctagcaa cctattcctt 57840 taccccctgt catcccctgc tgccctgagc ttgcagtctc tttcaaagac ccaccttaaa 57900 aacttgcatt ctgataaggc ccttgaagga atttgcttat caagttagta agtgacaaaa 57960 aagaaaattg caaagaacag gaatataaat tattatattt ctttattctt tctcacttaa 58020 gagtgaaatt gatatgtgta atgtgtacat ggtgccagaa tatttgtttt tcttcttata 58080 gaatgtccaa catcccagct tgcttccttg gatcagcaca gtcagaaaat gttctaacag 58140 atattaaatt gtgagtaatt tttttccctc aacttttatt ttggatttat gggggtgcat 58200 atgcaagttt gttacgtggg tgaattacat gttgctgagg aagttgtgag taatttatgt 58260 catttctaat catgtggtca gatgtctgtg gtatatgaga gaattttgta tacaaacaaa 58320 ttttactaaa tgcatgaaaa aaaaagtcca tgattttaaa atgcactttc ttttgtacct 58380 ttgcaggact gttacttttt aaatccttca aacttgaaga aatctgttat tctcggttct 58440 tgggctataa gattagcatt gtactcatag aattataaaa attttggttt tggaagagaa 58500 gttggagaat ataaagattt gtctcatttt atagatgaga aaactgaggc tcagagacaa 58560 gtaatttgcc caaaatcaca caatgactgg ctgagcaggg actggattct aggtctcttg 58620 cccaaccaat tctatcatga tgtaattcct aaggagaatg tcatctcaga tacacataca 58680 cacacccatt ttgtgtgtgt gtgtgtgtgt gtatatgtac acacacacac aaacatatgt 58740 acacttatat atacatacac acacatatat taatatatat gcatatatat gcatgttcta 58800 attcagaaca ttttcatcac tcccaaaaga acacccctgc ccattaagca gttgctttct 58860 ttacgtatat attagtatat acatacacac gagatacaca tatatttact gagttttgat 58920 aaatgcatac aaagatgtaa accaaacctc taacaagata cagaatatca ctgacactct 58980 agaaagtttc ttcatgtccc tccccagtct gtccttccat cctccatcct aggcaagcca 59040 ctgctccgat tttctctacc atagtttggt agaatgccat ataaatgcag tcacacaata 59100 ttaactcttt tgtgtaagac ttctttcatt tgctgtaatg tttctgagat tctttcatgc 59160 tgttgcatgt atcagtagtt ttttgttttg ttttgttttg tttttgtttt ttcagagtca 59220 gggtctcctt ctgtcaccca ggctagagta cagtggcgca atcatagctt actgcagcct 59280 ctaactactg ggctcaagct atcctcctgc ctctcaagta ggctaggctg caggtatgtt 59340 ccaccatgcc tggctaatta ttaaattttt tgtagagaca ggatcttgct tggttgccca 59400 ggctggtctt gaactcctgg cgtcaggatt gtttccagtt ttggattatt acaaataaag 59460 ctgagacaca tataagtctt tgtatggaca tatggtttca ttttattgat acatgtcaag 59520 gagtgggatg actggatcgt gtggtggata tatgtttaac tttctttttt ctgagataaa 59580 attagaaggc gatcctcctg ccttggcttt ccaaagtgcc gggattacag gcgtgaacca 59640 ccgcacctga tgcagttgtt gttgttgttg ttgttttaat atctgattat tattttattg 59700 tatttcattg aatatagcac agtttgtttt tacattttct tattgataga cacctaggct 59760 atttttctgg ttttggactg ttactaataa agctgctata cacatcctta taaaaatctt 59820 ttttgtgaac atgttttctt tttttctaag cattttaaat cacctttatt gaggtgtaat 59880 tgacttacaa taaattttat atgctgagaa tgtataattt gataagtttt gacacaggta 59940 tgcactcatg aaaccatcat cacaatccag ataatgaaca tattcatcac ccacaaagtt 60000 tacctttttg ttttaacccc agtcaccggg taactgctga gctccttcct gttactgtag 60060 actagtttgc attttctaaa cttatataca tggagtcatt catattttat gtgctctttt 60120 ttgtctgatt taaataatgc agtataatta ttttgagatt cattcatgtt attacagtga 60180 ttaatagttc attcctctta ttgttaagtg gattacattt tatggatatc caacaagttg 60240 tttatccatt cacctgatag acatttggat cgtttccagt tttgggttat tacaaataaa 60300 actgctatga acattcgtat gtaagtcttt gtatggacat atgttttcat tttattatat 60360 atgacggagc ggaatgactg gaacatgtga tgcatatatg tttaactttc ttttttctaa 60420 ttgagataaa attcacagaa cataactttt accattttaa tcattactaa agtccagtgg 60480 gttttggtat agtaataata tataaccatc ataattaatt ccagaacatt ttcctaactc 60540 ccaaaagaaa ttccataccc attaaggagt cattccctat tttccctttt cttttctttc 60600 tttttttttt tttttgagtc agggtctccc tctgtctccc gggctggagt gcacttgcat 60660 gatcttggtt cactgcatcc ttgatttcct gggctcaatt gatcctccca cctcagtctc 60720 ctgagtagct gggactgtag gcatatgtta ccatacctgg ctaatttgtt ttattttgag 60780 tggagatgag attttgctat gttgcccagg ttgctctcaa actcctgggc tcaagtaatt 60840 gtcccacctc agccttccaa aatgctggga ttacaggcgt gagccactct gcccggccta 60900 ttatctctgt tctgcccact tccaaccact aatctacttt ctgtctctat gatttgccta 60960 ttctggatgt ttctataaat taacttatac attatatggc cttttgtgtc tggcatcttc 61020 cacttagcat agtgatatca gtacttcatt cggtcttttt ttatgactga ataatattcc 61080 atagtatggg catacacatt ttaaaaattc attcatcagt gatggacatt tgggttgttt 61140 cctttttggc tgttatgaat aatgatgctg tgaacatttg tgtaccaatt tttttatgaa 61200 catacatttt caacgctttt gcatatatgc ctaagagtgg aattgctggg ctatatgcta 61260 attttttaag aaactatgaa gcttttgaga gtgattgtat catgggatat tcccaccagc 61320 agtgtatgag aggtccagtt cctccccatc cttgctatca cttagtctgg ctgatcttta 61380 acttaagcca ttctaatagt atctcattgt atttttagtt tgcttttccc taatgactaa 61440 ttatattgag catttttcat acacttattg gccatctgta tatcttcttt gagggagtat 61500 ctgttcaaat cttttgccta ttttttctta gtgagttttg atagtcattt ctatattctg 61560 aatataaatt atttatttga tatatgcttt gcaaacattt tctcctagtt tatggctttt 61620 catactttcc acacagttct tttgaagagc agcagttttt cattttgata aagtccagtt 61680 tgtcgattcg ttcttttagg gattttgctt ttagtgtttt gacccaaggt cacaaagatt 61740 tgcttttatg ttttctccta aaagttttat agttttaagt tttacattta gatttacgat 61800 tcatttttag taaatgttgt ctattgtatg aggtattgat tacagtttat gtatttttca 61860 catattgttc cagctccatt ttttaaaaag actatgcttt tacactgaat tgactttgta 61920 cctttgtcaa aaataaattg actacatata tgtgggtcta ttgctgcact ctctattctg 61980 tgttctgtgg atctatttgt ctgtcttgat tggtgtcttg attactgtag ctttataata 62040 aacctggaaa tcaggtagcg caaggcctct tgctttgctc ttttctttca aagttgttct 62100 ggctattcta tgtcctttgt atttctgtga gcatgtcagc atcacctttt caacccatat 62160 gcctgctggg attttgaatg agtttacctt gaatctagat atcgaaacaa ttagctgtct 62220 tgatagttat tgtcaccgtt ttataccgaa gaaactaggc atactaaagt aacttggcta 62280 acatcactta ccttgtaaga agtagaactg ggctgtttga catcagagct tattctttat 62340 accatttcct atgttaatta gaatacaata ttaatttcat aaaggtaaag gcatatctgt 62400 tttgttccta tttgattcct tgtgaaagca caatgcctag cgcacaatag acacttaaac 62460 ttatctgttg aatggacagg tgaatgcttt taaagtcttt ccatatagaa aattaagttt 62520 cattacattt gacttgatct aggttttcat ttcatagaat ggagagcaga ctctgtaaat 62580 attttgcccc agacctagct ttattacaaa cattgtctta attaggattc tgtctaccca 62640 gaatagaaat taactcaagc tagcatgagt gtatattgaa atttatatta aggataaagg 62700 aatgtctcat agatcccact caaaagaaat tagccagccc ttaggaagag actggaattg 62760 ggtttggaaa atacaatagg tctttctttt tatctgtagt ctttagtgag tcttcctcat 62820 ttttctctct gaagagataa gcattctctg catatatata gcattctttt agattttcgt 62880 gacataaagt attatttaaa ctttcataag gtatcttgat tttaagttgt aattccttga 62940 gatgattgtt ttctttattg ttaatatgtt tcccttcctg tttttttttt tttctttttt 63000 cttttgtttg tttttacaga ggtaaatacc ggattgtata cgtaactcca gaatactgtt 63060 caggtaacat gggcctgctc cagcaacttg aggctgatat tggtaagtga taaagaaaga 63120 tctctgtaaa tacttactga gttaatattt aaagttaaac ctatggatgg acactggatt 63180 tcacttctgt taaagtttat ttcaaacatt acttcctcca ggaaatctct gactctctaa 63240 cttgctgttt cacctatctt atcccatgat actctataat tccttttgct atagaaatta 63300 ggctctgtta tcataattac ctgtttatat atctgttttc ttctgctagg ctataaactt 63360 ttcaagggaa aaatatcact ttttaaaatt tatgtttccc cagtgcagtg cttggcatat 63420 aggcacttaa acatattgtt gaatgaatgt tgaatcctag gttctgtgaa attttaattt 63480 acttgttttt catgttctgt atctaaatta agtcagtgta gtggttttgt accctctttg 63540 ttcataagaa tcacttttca aactttaaaa aaaatgtagg taaccaacac ccaactctga 63600 aaattctgat ttaacaggcc tgggttggca cctggcattg gtggtttctc acaggtgatt 63660 ctgatatata gcccgggttg gaaaccacag tacctttgat tagttgccac tagtgagtat 63720 gatttattac aaaaaccaaa aacttagata agtcacagtt tatttcctag aacgtgtaaa 63780 tatagaatta gtcaaaagct gatagcactt tttttgtact taaaaatatt ttaagcctca 63840 gtatagtgag acctcatctc tacaaataat tttttaaaaa attggccgag cctggtggtg 63900 catgcccata gtccaagcta cttgggaggc tgaggtagga ggattgtttg agcctgggag 63960 atgaaggctg cggtgagcca agatcatgct actgcactcc atcctgggca acagagcgag 64020 accatgcctc aaaaaaaatt tttttttctt cttggtggtt aggcttaact atccaagaat 64080 tgcaatcatg gcttctattg caaatgcccc tatttcccac cttcagttgg cctaaccaaa 64140 tttaattttt caatatcata tgatcttttt gtataattat gtattcaaat aattccagat 64200 aggttaggtt ttcgaattgc aacgtctcat ttaatggtta ctttcatata actgtaggaa 64260 agcatttgat aatttttcca acaatgtaat gaaaacaaac ttgtatcttt tttattatgt 64320 gttaaaacca acaaaagaat gagggcagca attaacattt cattaaatat attagcaatg 64380 agtacattta tgagctctta aactccctta ttgacatact gtattttttg cctttaatgg 64440 acaatgaatt tgatatgttt cctaataggt tgtatgaagt tattgtgaat atttcacttt 64500 ggattaagaa taactaccct atatataaat ttcatggttg tattgcaaaa gctggggtct 64560 atgtccatag tggtttgggt acgtttttac tatttgcttt gtttctgtga tagtgttaaa 64620 tgaataataa gcttaagtat ttaagcaaat acttaatact tctgacaagt agttagaact 64680 ctctattttt gtttttttgt aatggatgag ttatggacac tgcaattatt agagcagcgt 64740 actttgctta tgatggatga aaatgttctc tggttgactc agtgttgaat aaaaagggat 64800 acatgaaata aaaattattt ttgaaatatt ttcctttgcc ttttgttgcg ggaaattgta 64860 caatgcttgc aaaaatgaat atacgcagga tattatttgt acagcagtct gacatttagc 64920 taatcagatt cctcattttt aggtaaatgt taaattactt aagtagtctg gatttttaac 64980 agaaacagca aacatagttt tatagggagg ctccttacca accagacttt taacttaagt 65040 gaatgttggc aaaagcttgt ctaaactgat ttccagggat aaggtttagc tccattaaaa 65100 gctagtttgt caaacctgta actaaagctt tttaaaaaat gaaagtttta aaagagacca 65160 tcattctgtt ttaacctatt taatttaaaa tctgggctga agtaggagta ttgcttgaac 65220 ccaggagttc gagaccagcc tgggcaacac agtgagaccc catctctgaa aaaaaaaaat 65280 gagctgagca tggtacctgt tacagtgcta gttatgaaag aaagaaagag agagagagag 65340 aaggaaggaa gggagaaagg aaggaagggg ctgggagtgg tggctcacac ctgtaatccc 65400 agcactttgg gaggccgagg cgggtggatc atgaggtcag gagatcgaga ccatcctggc 65460 gaacatggtg aaaccctgtc tctactaaaa atacaaaaag aaaaaattag ccgggcatgg 65520 tggtgggtgc ctgtagtccc agctactggg gagggtaagg caggagaatg gcatgaaccc 65580 gggaggcaga gcttgcagtg agccgagatt gcgccactgc actttagcct aagaaaagga 65640 aggaaggaag gaaggaagga aggaaggaaa aatcagtcac tcactcaggt ttagtttcaa 65700 aagccaaaac agtgataata ttgaattttt tccagccact cagtagtacc cagagaattt 65760 tgatacaaat aactgacttt gaccccatgt ttagtaggtt ttttttttgt ttgtttgttt 65820 gttttttttt tttgtctttc ttctccacac tctcttagga ctgttgtagc ttgtaatgtt 65880 agtgaattgt aattgtttat ttgcatgtct gtctcctctt ttagaattgt gaactcctca 65940 ggtcatggat tgtattttat tagtcttttt attcctagaa aagtgtttgg ataataatag 66000 atatttatta accataatag gagtagtagc atttttgtgt gtgtgtgcca ggccctattt 66060 tagcatttta tgtgaatgat ataatttaat ttttagagca tctagaaaat gttaggtacc 66120 attattatcc acattttact tgtgagagga ctgagacttg gaaagcttaa gtaacttgct 66180 taaggtaata cacatggcag atggtggagc caggttctgc atctgggcag tctgacttta 66240 gagcttttta atcatcctcc tcctagtgtc cgaacattat taatgctcag agaagtatca 66300 aagaatgatg atactcattg agggaaaaaa ttattcttaa gtatcaattt gttaattgag 66360 gacaaaagca ctactgttac tactgtgaaa aatctgaaaa cattgtcacg gatgatttta 66420 caataacatc cttttctgac atgcattaca acacactatt gattccgttt caatgtttgt 66480 gtctggtatg ggggcggagt agagaggcta ctacaggaag aaagaacaaa taacatttct 66540 tcttactact ttgtgcatca tgtgatttag ctcctcccat accattttac attagaaaat 66600 gtggctgtcc tcctgtgctc tagtactggc atttcagagg actctttgca atatgatatg 66660 tgatcaatca tggatggcga tgcagttaat ttcagtagaa atttgctgac tctttttatc 66720 tcttttaata gctaatgcat gagataaaat tgaaggtatt accaaggaga aatgcaggtg 66780 gatagttttg gaggcaaagt cacagtaagc aattcatctc tccaaggaat agtgatgaaa 66840 gctgagatcc aataaatgtc ttgtttggat taatacataa atatttcctt ttaaaattct 66900 taaggctttt attcatatat ctcccctctc cctatttcca ataatgattt ttggtgttaa 66960 tatgatgata tttatgcttc tgtttttata ggaaccaaat actttgattt ggttatttat 67020 tctcctttgg agatgtagat gagtttattt tttcctttcg agctttatct tttcctttat 67080 gtgtttttct ttttttacag gtatcacgct cattgctgtg gatgaggctc actgtatttc 67140 tgagtggggg catgatttta gggattcatt caggaagttg ggctccctaa agacagcact 67200 gccaatggta agctttgcca agtctgatgt cccgaaatta cattcttaat aaggagagca 67260 ttcaggattg gggagtggta aagaagctga agacttcact ataaaagagc aaatggataa 67320 tgtaaaaaga gaactatttt tttaaaaatg ctaaagttgg tatataatct attgaggaat 67380 ataatagaac aaggcttgac aaaccttttc tgaaaggacc agataataaa tatttcaagc 67440 tttataggcc acatgtagtc tgtatcacat attcctctct ctgttttttc ttttagtaac 67500 cctttaaaaa tataaagagt tacatttttc actggtgggc cataacaaaa caggctgtgg 67560 gccatatttg tccgaatgtc ttctcagtga tctttcatcc gtatgtcctt ttactctagg 67620 atgctgtgaa atcctggtta ccccttcttg tatcacattg aaaacctaaa gtttgaacta 67680 ttctatagaa attttattaa agcttttggt attagaattt ccctttcttc cctaattata 67740 aaaaatagca aattttggcc gggcatggtg gctcacgcct gtagtcccag cactttggga 67800 ggccgaggtg ggtggatcac ctgaggtcag gagttcgaga ccagcctggt caacatggtg 67860 aaaccctgtc tctactaaaa atacaacaat tagctgggcg tggtggcagg tgcctgtaat 67920 cccagctact tgggaggctg aggcagggga attgcttgaa ctcgggaggt ggaggttgca 67980 gtgagccgag attgtgccat tccactccag cctgggcaac aagagcgaaa ctctgtctca 68040 aaaaaaaaaa aaaaaaaaaa aaaagtgaat ttttacatga atattctaca tgattggcat 68100 atttacatga atggtttaaa aacccacaat aatagcactg ttttattttt tattttgaaa 68160 attgtagatt cacaagaagt tgtaaaaaaa aaaataccta tatagaggtc ctatgtacct 68220 ttcatccagt ttcctgaaca gtaacatctt gtgtgactat agtacaatat caaaactagg 68280 aatatgacat ttgtacagta tctagagttt attcctattt ctctagtttt gtaagtactc 68340 ttttgtatgg catgtgtatt gttctataca gtttaatctc atgtacattt gtgtaactac 68400 cactgcagtc aggatgccaa atgttccctt accacaaagc tccctggagc tgttcttccc 68460 acccctggcc ctagccactg gcaaccacaa atctggtctc tatctctaaa atattatttc 68520 aagaatgtta tatacatgga atcatgcaat ttgtcacctt ttggaattag tttttttcac 68580 tcaacataac taccttgaga tctatccaag ttgtttgtgg tcatgtgttg cctaacaaca 68640 gggatatgtt ctgagaaatg tgttcttagg acattttgtg gttgtctgaa catggactta 68700 cacaaaccta catgataaag cttactgcac acctaggcta tatgatagag cctattgctc 68760 ctaggctgta aacctgtaca gatgttactg taatgaatat tgcaggcaat tgtaatacaa 68820 tggtaagtat ttgtgtatct aaacttatct aatgtagaaa agacacagta aaaatacagt 68880 ataaaagata aaagatggta tacctgtata gggtgcttcc tgtgaatgga gcttgtagga 68940 ctggaagttg ctctgagtga gtgagggagt ggcgagtgaa tgtaaaggcc taggacatta 69000 ctgtacacta ctgtagactt tatacatatt gtacacttag gcgacactaa atttttaaaa 69060 ttttctttaa aaattttctt tcttcaataa taaattaatc tcagtttact gtaactttaa 69120 ttcataaacc taaaacattt tttgactttg gactcttgta ataattctta gattaaaaca 69180 tgaacacatt gtacagctgt acaaaaattt tttcttcctt gattaatgca ttccataagg 69240 ctttatttta aaattttatt atttttattt ttaaaacttt tttgttaaaa actaaaatac 69300 acacatatca gactagacct acacagggtc aggatcatca atgttgctgt cttccacctc 69360 cacgtcttat cccactggaa gttctttagg ggcagtaaca ctcatggagc tgtcatctgt 69420 gataacaatg ccttctccta gatacctcct gaaggacctg cctgaggctg tttttcagtt 69480 aactttaaaa aatgaatacg taggaggagt atactctaaa ataatggaaa agggtatagg 69540 taaatacgta aaccagtaac atacttgttt attattcatc aagttatata ctgtatataa 69600 ttgtatgtgc tatacttttt aatgcctggt agtgcagtag gtttattgac agcagcatca 69660 ccacaaacgt gagcagtgcc ttgtgctaag acattatgct ggctatgaca tcacttggtg 69720 ataggaattt ttcagctcca ttataatctt atgggaccac tgttccacat gtgctctgtc 69780 attgacagaa atgccgttaa gtaccacatg actatttttc ggtggtctgt tcctttttat 69840 tattacagag tattccacag tatggttgta ccacagttta actgatcacc tgttgaagaa 69900 cttttgggtt gttttccagt ttttgactat tatgaataaa gatgctatga acatttgttc 69960 atatctcaaa ggttctttat ttttttttat ttatttttct ttttttgaga cagtctggtt 70020 ctgtcaccct ggctggaatg cagtggcgcg atctcggctc gctgcaagct ccgcctcctg 70080 ggttcacgcc attctcctgc ctcagcctcc cgagtagctg agactacagg cgcccgccac 70140 tgtgcccggc taattttttg tatttttagt agaggcagcg tttcaccgtg ttagccagga 70200 tggtctcgat ctcctgacct cgtgatccac ctgcctcggc ctcccaaagt gctgggatta 70260 caggcgtgag ccactgcgcc cggccttcag agattcttta atgggtgaat ggttaaacaa 70320 cctgaaaata taaaagtttt catttctctg ggataaatgt ccaggagtgt atttttagtt 70380 tttaaggaat tgtcacaaac ctgttttcca aagtggctgt agcattctac attcctgtca 70440 gcagtgtgtg aatgatctag ttatccttgc caccgtttgt tgttgcaact gttttttatt 70500 ttagccattt cgataggtgt cgagtggtat ctcactttta atttgcattt ctctcatggc 70560 taatgatggt gaacgtcttt tcatatacta atttgcctct ggtgaaattt cttacataat 70620 tggagtgctt gtttttttct gttgagtttt aagagtttaa aaaatacatt gtagatatga 70680 gtccttggtc agatacgtgg tttcaaatat ttctttcact ttgtagcttg ccttttcatt 70740 ctttttaccg tgtctttcac agagtaaata tttaacattt tagtgaaatc cagtttatca 70800 ttttttcttt tatggattgt gctcttcacc tagccctaga tcctgaagat tttctcctgt 70860 ggttctttcc taaaattgtt acagttttat gttttaagtc tgtgatccat tttgagttaa 70920 attttgtata aggtgtgagg tttaagtcaa ggttcattgt tttcccaata gattaaattg 70980 cagcagatcc tttgttgaat aggctgtcct tcccctgtta aattgcgttt gcccctttgt 71040 tgaaagtcat gtgggtgtat ttgtgtgggt ctatttctgg gttctctagc ctgttatatt 71100 aattttgaac gaataaagtt ggcttatgtt taagttttct tggtagtagc gaggcaatgg 71160 tgccttctga gcccaggatt tcacaatttt gtgagtaaac tgtgttagaa attgtttgtt 71220 attcttttgg taggttgtct agttcaattt cattgctcat taatcttgct tatagatagc 71280 aaattgagag gcatctcaaa aatagtatct tttgttagct tatctcacag agtttggttg 71340 gagcagatat taaaacaaca aaccaaaaat aaattaaata tactagttag caagtttata 71400 ttgagggaaa atcaaaccat gtgaattgag ctccaatgat gtggctggcc ttgggtcaga 71460 ttttagtatc atggttcaac aaggtagcta ttaaaatctt catacttttt cttgaaataa 71520 ttctttagta gtcacatagg acagcacaca ctcatggatt tcttctttcc ttactgtctc 71580 tttattctca gcctcctgtt ccttctcatc tccctgacct tttaatgttg gccttccaga 71640 aactttagtc tttggaccta cctttgcact cattttcttg gtcatttcac ccaacataca 71700 gttttatgtt attttatttt ttttattttt gagatggagt ttcactcttg ttgcccaggc 71760 tggagtgcaa tggcgtgaac tcaccttact gcaacctctg cctcccgggt tcaagtgatt 71820 cttctgctca gcctccccag tagttaggat tataggtacg tgccaccatg cctagctaat 71880 tttgtatttt tagtagagat ggggtttcac catattggcc aggctggtct cgaactcctg 71940 acctcaggtg atccacctgc cttggcttgc caaagtgctg agattacaga tgtgagccac 72000 cacgtccagc ctacagtttt aaatatcaag tctatactga ggactcccaa atttttatct 72060 ccatcataga ctgatatcag cagtatatga gtgattcagt tgtttttgcc tctttgccag 72120 catttggtgt tgtcactatt agttcatttt agccatttaa tagaatatat gtacatatat 72180 atgtgtgtat acacaggcac acatctatat aactactcaa catgcctctg gtgagatgac 72240 caacaggtat ctcaaactta acctcttcct aattgacttc tgcatagcac tccagatctg 72300 ctctttcctc actctcctcc atcttgttta acagcagctc cattggccaa aattttggaa 72360 ttttcctcaa tcttttctct ttttcttaca ctccactgtt tatttaaaca gtaaggaaat 72420 ctcgtgaggt cttcagaata tatgcagaat taaatcactt ctctcttgat ccctgccatt 72480 ccccaggtac gggccaccat ctccttaggg cctcctgctt tcactcttcc catccctcat 72540 tctgtttcaa cacagcgtcc agagtgatac tttaaaaatg aagtctgata gatcatgtct 72600 tcggctcaga accatctagt agcatgccat ttcattctaa ataaaggcaa aagtccttat 72660 gatgagttac cgatcctcat gtaatctggc cttccatttt ccctctgatc tcattctcta 72720 ctggtctcct cattcaccgg atgcagccac accaccctcc ttgtttttct tcggacattc 72780 caggcatgct tcagtgcctg ggctttgcgc ctgctgcttc ctctccctga atacgtttcc 72840 cccacattgt ctataggatg ttctcccata cttctctcag atctcttgga tttaggcctc 72900 ctgggccacc atatttgaaa tatcagatta gttccccctc ccccatcatt cagcattcct 72960 cgtaaatctt tgctgtttta aaaatagcac tatcactgtc taacttactg tgttatattt 73020 tgttaatttt ctgtgagttc ttcttcacta gaatattctt tgtagggagg agtttttgat 73080 tgtttggttt ataaaatctg gaacaatacc tggcttatag gaggtgctca atttataatg 73140 gggtgaatga atgaatgaat gatgatgaga aagctgagaa tcagtaaagt gactttccaa 73200 aacaggtagt gggcagtata gagttgggcc ataaatagct gcaccataca acatcctgct 73260 agtttctaaa gcaaatgatt tgaaagaggc ataaaacata atttctgccc tcaggtagct 73320 catagttcag taaaggagtt tagattcata cctataacag tagaagtaat agcaccaaat 73380 gaaatatggt attatgaagt ggtacaaata atataaaaag atgaacagtg ttagtagtac 73440 atgtttagaa gggatttctg tggtgaaagt cactaggcac agtgcacctg gaggaccgat 73500 ttccattaat ttagaatggt ttaaagtaag cttttggaaa ctaggaagat tactttctgt 73560 aatcctttcc taggcctttg attctagaag gattgtgtta aaggagtttt aaatatttta 73620 tacagttctt aaacattgtt aagcttgaat taaatctttt attatgtctg gccatggacg 73680 tcattggatc attttcattt cttgggagga ttaataaagc acattccttc tgttgggcct 73740 ccagtgcggg gagggtgttg gccgagcagt ggctgagaaa acgtttttcc cctggtgttt 73800 tcaagaaccc tctttattag ctaagtggtg agacatgcca cctggtggtt atagtagtat 73860 catttttctc actgttcttg gtgcttttct tctcgttctg attccagtta tactaggaca 73920 actgctataa acctggaatg tttcacacta tattatttca gtaatttcaa aaacagcaga 73980 aatcactaag ctgtttggca caaagattcc tatttggaag gaatcagaca aagtgagtgt 74040 tgagaaagaa cagccaggca gaaagctttg catcagtctt aaagttcttt acatttcaag 74100 taagaggaat tgtgaaatcc ataagacatg tggggttttt ctattacttt ctccccagta 74160 tctattacaa agatcagcac atagtaggta ctcagtaact atttagaatg agtgcatgaa 74220 tgaatgaagt atgtgtgatg ttatggagta caaagttaga attagcaaca tgacctgaat 74280 ttagaagcag gtgggatact tatacttttc tcagtctgtg ggcaccacac cattgaagta 74340 tatgtctaag attaatttat atttggttgt ttgatttagc aaaacttgct gcctgttaaa 74400 aaagaaatta agacctgtca acttaaagaa tacattttgt gagttaagaa ctaaatgaca 74460 gtataattta ttacccaaag cagtttgctt ctgaaaatta aagagttcaa gctattaata 74520 attatgctgt gactgcaggc ataaactggg aatgtcctgg caaatgagga tgtattgtca 74580 cctttctcag cctgcctgtg tgttgttttt aagcttcact ctagtttata tattttaaat 74640 gtcataaaat accacatact tataagagaa aaggttctat tcattgctga agtggaagct 74700 tatcattaat ttttatttat ttattttttt ttccagtttt ggaattctta ttactttgaa 74760 cccaagaacc actgataact agcacaatcc agtgaaacag aggaagcagc agcttaatca 74820 aaggaaaaat acatttaaga ttataagtct ggttataagc ttaaaaagtg acccagaaag 74880 ggatatcatt gctaaaaaaa aaaatcccct tgtgacctgg gtacattttg caaagccaca 74940 ggtttgcagt gttacacaag ggccaaagga ggccatgagt tgtctttggt tgtggggccg 75000 gagggtaact gttcatgaaa atagtgagtg tctgaagatt aagaaaatca tgctgcagca 75060 gaggagaagg gagaggaagg caggaaggga aaggagatgc ctgagggtca aaagctgagc 75120 ccaagcctaa gcccaagctc aagttcaagc cccagcatgg cacaattttg tgaattaact 75180 caggctgagt tgcctccagt ctttggaatg tcatcttata ctggtactgc tgaggcagag 75240 ggcagtaatt ggttctttgg gataggagaa ggggcagttg ctgaaataca aaattaatag 75300 tcagcatccc aagttcctca attgcagcca aaatacatgt gttcaggcct ttcggcagta 75360 ccgcccccag aactaccagc tgtagtgtgg tctattccca gacagcaaca tgcaagaata 75420 agtttacaat acactcagcc cttgtggctt aagatcaggg gctcagaggc tgtgacaact 75480 catgatgctg aaaatgtatc caatgaaaac gaagtactag cttgtttagt agtaacgaag 75540 tactattaat ttttaatata gtctgatact ttattttcta attgtagaag caacattctt 75600 agctatatct ttctagaatg ttgaggcaaa agagtaaatt tatagtgatt ttcactgtta 75660 ccagattgct ggaataggga atttctggta gcaagatggg aatttttaag ttggaagggt 75720 ctaacacatc atatagccgt ctccatctca ttttttttgc tgaaaaaact gagcccttgc 75780 aaatgtcagt tgcaaatctg ggagtagtac tcatgtctct gaagttgtta tatagaattc 75840 tttttattta ttttaataac aatatttatg atagttgaaa ctttttgagt gcttactata 75900 ttttatttca tgcattatgt tcagcacttt acatgtttta tctcacttga tattcacaac 75960 tttatgagat tggcactgtt attgtagcca ttttatagat gaggaaactg aagcttagag 76020 agttaaataa agagctcaaa atctcacatc tagtaagtgg caaaaacagg atttcagctc 76080 aagcaatctg attccaaaac agactttttt cactgtgctg ccattctttt gcctggtttt 76140 tctgttaact tcttaaatat atgtcatgtt tcatgcttac ttcctcattt tcataaatat 76200 attacctgct cacttataca ttatattgct tagaaacaaa cccaaccctg ttttcttatg 76260 gactgtatcc tgaaaatcac tgtttttaat atgtggttaa acaagtgttt tattagtgca 76320 tttatataaa ttatttaacc aaaacactta accggtgaaa gtgctttact gtgtgagaat 76380 gtgcatgttc taagaacctc taatttttaa acctccctta ttctcagcct tatatttgtt 76440 aaaacctgtg tgttaacaca gatgcaccca tgttaggggt taattagaga aaccaacctc 76500 tttatagatt agcttgttca tctttaagtt gctaggcagg cactgtaaat tcagagaaca 76560 atctgattgt aagccacaaa tcaatgaaat taattttggg gttgcctttt aaaatagtgt 76620 cacaaaattt aaggataaag aatgcaaaaa tgatgccaat tatctcatca cattagtttt 76680 gatttaattt ttttaatttg aaaaaaccta ctcttaaact taattgattt ttttaaatat 76740 aagtttggag ataattttta attcagtaaa gttatagtga ttgaaaaagt agtttataat 76800 ttttaataaa ttgatcttgt tttaattttg agtcatattc tagaagtgct tctttgcaaa 76860 ttggtaaatt gcacatacat ttccacttat atacaagata attgctatgg ttggtttgta 76920 taatagatgc agtgcatctg aagagctatt ttatgagaat attgtttctt gtatctgtca 76980 cgagccaaaa agaatatttt taagaaagtt atattcttgg tgatagaaca gctgataatt 77040 tagaaacaac tgtaagacag tccacttttt ctgattatga aataatacca tagttaagtg 77100 taatttccta taatagaata aaaacacgag ttctagtttt aggggaggca tgttgttacc 77160 gtaccttaga atttctggaa gatgacatat tcatgctttt cctgataact gctgagtctc 77220 ctgctctgtc tgccaatcca gtcaagaagc ctttgctagc aatcaattaa taatacgttt 77280 catttataca tatttcctat atatagtatg ttattgatta tctcagtacc actgaagaga 77340 ggttatctgg gtcattggag ctttgcttct agatttgtga agccataaac ctatatattt 77400 aaaataggag gccaaaaaaa aacgaccatt gctttatata gttagatttt cagtgaattg 77460 agagtttatc atttgtaatt atacattaat caaatataag gcataatata cccccctgct 77520 tatatcagca ccatttcaaa tgtaatgtta aaaaataata aatggagaag tagatagcta 77580 acaagtaggc ttaatttaat aagacaaagt aaatggcatt tggaaacctc atggatttaa 77640 tgttttattt aaatgatttc tgatttttaa aaagtaaata ttgtttccag aaggctgaga 77700 aacaagttag tagggagatt ttttctttgc aaaaaaattt tacagttgtg tctttaacat 77760 tgtaccacaa actgttgtcc taccagtctc tttgtaagaa agctatagac atgttgggaa 77820 tgaatgagct ctttcctttt taaaatatca gttttacatc attcaggttc caatcgttgc 77880 acttactgct actgcaagtt cttcaatccg ggaagacatt gtacgttgct taaatctgag 77940 aaatcctcag atcacctgta ctggttttga tcgaccaaac ctgtatttag aagttaggcg 78000 aaaaacaggg aatatccttc aggatctgca gccatttctt gtcaaaacaa ggtaaggatt 78060 taatggttga tgaattttgg taatgatttc cttttttttt ttttaacaac ttatgtattt 78120 tatgttattt acgatttcct tctaatgcat atttaacata tttcaaattc cacctagttt 78180 tggttcaagt caagcatgat gttatataat caattcagtg attgagacta gtgtattttt 78240 aaaagcagaa accaattctc ctaatatttt aataccccat tctgttgctt aaacagggca 78300 tatactattt atttttattt tttaaaattt tacttattta tttatagaga cagggtctct 78360 ctgtcgtcca ggctggagtg cagtggtgtg atcacaactc actgcagcct caaactcctg 78420 ggttcaagca gtcctcctgc ctcagtctcc caagtagctg gaactacagt cttgcaccac 78480 catgcctggc taggacatat acttttaatg attgataagt aaacaagcaa acataaaatg 78540 actctttcat ctgaattctg tctagtttac taattacatg acttcagtct taaggagctt 78600 agaaaaggtc accttacaaa cacagtggag cctgtattgt gttccaagga ctattgtagg 78660 cgctttctat ataaaatgat ctaatttaat ccctataact gctcagtaag ttacgtatta 78720 ttttcatttt attgttgagg aaactggcat tagtactttt ttctgtttat tttgtttaaa 78780 ggcattttaa atatatatgt taagaagttt tcaaaagcct atattttact ttttataagc 78840 ctttatttta ctatttgaga cagtgtcttg ctctgtcacc caggctggag tgcagtggcg 78900 caatcccggc tcactacaac ttccacctcc tgggttcaag ctattctcct gcctcagtct 78960 cccaagtagc tgaaattaca ggtgtgcgcc accatgccag gctaattttt gtatttttta 79020 gtggagacgg ggtttcacca tggtggccag gctgatctcg aactcctgac ctcaagtgat 79080 ccacctgtgt tggccttcca aagtgctgga attacaggtg ttggccactg cgcctggcca 79140 gtttataatt ttaaacatta aaataaatgc ttcttgtcca atcatggtgt ctcacaccca 79200 gaatcccagc actttgggag gcagacgttg gagaatcact tgaggccagg agttcgagac 79260 cagcctgggc aacatggtga atccctgtct ctacaaaaaa tacaaaaatt agctgggcat 79320 ggtggtgcat gcctgtagtc ccagctattt gggaggctga ggtgggagga tcatttgagc 79380 ccaggatgtt ggggctgcag tgagctgaga tcacaccact gtactccagg ctggatgaca 79440 gagcaaggcc ccgtttcaaa aaaaaaaaaa aagcttctac caatacaaac acaaaacaag 79500 catagacaaa tagagtttaa agaacatcat tggtgttttc ctctaaaggg aatattgatg 79560 ctaggccaag aaaatcctgg agttattctt gaggacctta aggaataatt gaaatgtagg 79620 atttgctcct ggctttcttg tcctatattc agaataaaac aagaatggat cgaatatatt 79680 ctgagtgttc tggccattct agtgctctct gaagtgagta ctcactgtgt ttcacttccc 79740 tttcatccta aagaggaaaa gttcttttga agaaggctgt ttgtcctagg ttagagtctc 79800 cacagtcaga tcattatctc ctcctaatct ttgatcctgt tcagtctcta tggtactttc 79860 ccttataata acactctcta tggcactttc ccttataata acactctcct ttttaaagca 79920 gtttgccttt tttgtgtgta atattgttct cctggttttc tgacgtcctg gtcctcttat 79980 aatcctatgc aaatgtttct ttctgttttt catgttgact ctgctaattg aggtctttgt 80040 tactttttag ccgagactat tataatttcc ccaacagata cccctctccc cagtgcccct 80100 tgttgctttc tatgcagttt acaaattatt gtctgcaaac acatccttaa gtctggaata 80160 cctttctgga actccttact aggaaataaa gaccagactc agtgtaacat tcaacagtat 80220 tgaagatcta ggtatttaat atgaattttt ttttttaagg agatcaagaa agatttttgt 80280 acccattttt aatcctccaa gaagacttag gatagcagga aaccattgag agtcagaatg 80340 ctttctacag atcttaggtg aacagaaact ttcctcttca tgagcagtga ggtagagggt 80400 aattaaggct tcagagcatt gcccgttatt tccatcttct tcccttcctt taattctgct 80460 aaattccttt aatttgttta tcagtattca agtattttta tccattgagc taaggtgttt 80520 cttaaactaa ccctattttg ttaaagtctt aattataata tattcatagt acatttaagt 80580 gagatagatg agtctctcat ataatttagt ggttagatta gattagaatt ttctcccctc 80640 agaaaattaa gaggaaataa aagtctgtag caaatcactt ggcaaaataa tggctccttt 80700 tgtaatagga atttttactc ttttgattta tctgttacat aagttcaaat ttttacatat 80760 tttccacctt ttttaaaaaa gagtgatatg tagtcaatat caatttgagc aacactgttg 80820 catataaatt gaaaaggact ccaattttct aattccgtac ctcagttgtg atcactgttg 80880 gtattttggc atttatgtag acttcctttc tctgacccta ctactgtgca gatatatagt 80940 tgcagttttt tgttgttgtt aagttgatac agaaatagtt gcatactata tccattattt 81000 atgcaaattt tttttcattt aaagtatctg ctatctttcc atatattgca ttttcttaaa 81060 ttagagcctt aatatatagg atattacaat atctaggttt tgttgagtag ttttttcttc 81120 tttgaaaaca tgtttttaaa ataaggtttt tttttttttt tttttgacat ggagtcttgc 81180 tctgtcgccc aggctgtaat gcagtggcgg gatcttggct cgttgcagcc tctgcctcct 81240 gggttccagc gattctcctg cctcagcctc ctgggtagct gggattacag gtgcatgcca 81300 ccatgccctg ctaatttttg tatttttagt agagacgggg tttcaccttg ttggccaggc 81360 tggtctcgaa cttctgagct caggtaatcc gcccgccttg gcatcccaaa gtgctgggat 81420 tacaggcgtg agccactgtg ctggccttaa aataagattt ttatacacta aaagaaaact 81480 tacatttttc actccattaa gtagttcact gtgaattttt gatattgaag cccatttggt 81540 tgctgtcaaa aatagatttg aacagattat tcagtatgac tcttgtagtg aaattattgc 81600 cttgtttcct ctgcttaagt tttcagtggc ttttgccaca gtccttaaag gttttataat 81660 ttttttaatg tttaattttt aaatgtttgc ttaatatttc ttagtatgag tgtagataat 81720 gatgaacatt tagatgactt tttactatta taatgttgca gtgaatattt gtttacattt 81780 atcttttggc caataagcaa atatttttgt aaattagaat cctaaaattg aaattggatc 81840 aaaagttata tgcacttgaa attgattaac ttttcctaaa tctaaaatag tatagtcttt 81900 tttatattgt cagcataaat gaatgcactt atgtaaatga atatttttag gcgttaagta 81960 aaatattctg tggaaattga acatttaagt tgtttatact tctatggaaa tcgtttacgc 82020 ttttaataaa gaagcacaag tttctacaaa atacattcta acagatgttt tctataacat 82080 tcagtctcaa gattactagt aaatacttct ttgaactgta aaagcaatct ttcaatatta 82140 taagaaagct cttgctttag taaacattta gaaactcagc tttattatca taagcaagaa 82200 taagaacagt gtaacaagtt ttatgcacac tcctttgtaa accctcacca gactaattgt 82260 taatctggtg ccttgcattc cccaaagtat ttgtatctgt cgtttataag tttttatcaa 82320 ggtttcagct aaaacaaata aatttgtttc tggttttagc tttaatttga actgaaacag 82380 tcaaaactga gttttgggga cttcacacaa ttcatttgga tatttgattc tccataatgt 82440 tttaaatttt catgcactta aatatatcat tatttttgat aggctttctt cctttagtct 82500 tttctttaga aggtagaaag gaagaattaa ataagataaa accaaacggg tctgaagcat 82560 gtataaagta tatatgtttg ctcttttgtt cttctttttc tttagttccc actgggaatt 82620 tgaaggtcca acaatcatct actgtccttc tagaaaaatg acacaacaag ttacaggtga 82680 acttaggaaa ctgaatctat cctgtggaac ataccatgcg ggcatgagtt ttagcacaag 82740 gaaagacatt catcataggt ttgtaagaga tgaaattcag gtatgaggat caatcatcat 82800 tgctctccgt tgctcatagt ggaagtggat atttctcaaa tgtttattta ccagatcttt 82860 attgaatact ttctttgtgt tgaacataaa gcagtccctc tgataaatgt gggagaacaa 82920 acttgcagat tagtataaat agcaatctgt acctagtgct taggtgcaca gaggagggag 82980 gaatagctct gtcaaggtag ttgtgtaatg ggggtggtcc atccaggaaa attcaattag 83040 agtccaaaca tgtaagtaga agtttttcaa gtatgccagg ccagtaggtg atgaggggaa 83100 aggaattggt tatagaattc caggaagaag gactagcagg tgcaaagaca ctttgatatg 83160 agaacacata ctgggttcag gaaatgtgac tggtatggaa tggttggagg gaaagacaat 83220 gtggggtagg aatggcacaa agtatggaca aagaggcagg gtggaaccgt tagagacttg 83280 agagaacagt tgaatgggtc ggttggccag gttatagatg gctttaaaac ttgcaaagaa 83340 gcagtctggg cttggtatca tatacctgtt agttttcact gactacttta gccttagaat 83400 ttttagttta gatacaattt tctgtaatag gtaaaacgga ttaaagtaga ataactctgg 83460 ctgaagttaa tgtgagggaa aaggaggtac aagagtctcg tctctagacc ttgaagacac 83520 tccctgttgg ggtcttataa tccttggagt gccgcagaat catttgaaaa ccatcttgat 83580 gtactactct gtgtttttaa ataagataat aggattatag aaacattaga ctggcagcaa 83640 taagttggat tgatttgaag aagagaaact gaagaaggga aagggtatcg atgcagctat 83700 tgtgaaattc tacagttgag attcctgacc tgattggact ggctcagtgg gtgtcataga 83760 ggatttattt gggaggattt aagttcaagg cacatgagta ggtttaagtc aacaacttga 83820 cactgtcaac atgaaatcca cactgtaact ataagtccga ggaagagccc tctcctgaag 83880 ttaggaattt aacttcagct cttgcatttt ctgtcccacc ggtcatccat ttcttctcta 83940 tccatctcct tttctgatat ctagttgtta tcagtgttgt tgaaaagctt aagtatgatt 84000 catattcact gtctataaag ttcactacac atagtcatgc tgtaatgcat acccgcctga 84060 aagcatctgg tctctctttt ccttctttcc aaagataaga ataccattca cagctgttta 84120 gaatagaaat tttatccaaa ttcttcagtg tttatatttt tgttctgtta tttcagtgtc 84180 ttgaatattg tcaaatgaca tttattagct actactggta ctactgaatc ttaataatca 84240 atcttcaagc cattaactga ccaatggttt cttctatctt aatgtattag taattattca 84300 tttagagtaa aacatctccc agaacatgaa agaatacaaa ctttattcat gttacgttgt 84360 gacaggagac tttgttggat gcgcctgatt ttcctgccaa ttcacagctt cattaaaaca 84420 gtaatgcttt gaaatatggc ttaggaaact tcacaatgat cattaattac acctaatttc 84480 tggaagagta tatgcatgta tgtgttgcgg tattctccct tgctgtggca ggatgtcaca 84540 aatttttatc cacattacga aaatttaaaa attgatatgg ttttttctcc ctacgttgat 84600 atcagatatt ttgttttatc tgacagctgg cccaatgtac tcctactttg ccattataaa 84660 gaattcaaaa gcttcatatt tgcattgaaa gttctcaaac actttgtaaa gatgatgaaa 84720 gtatgtttca tcatctatgt agaatagtca ggtgttcttg caattgatta cttgctaccg 84780 agaattgaat acctactgag tgcataatgt atagaattct agatattcac ttttgtgtgt 84840 ttttacagtt gttatatacc ttagtgtggc tctaaaagtg gaggtgacag ctgtagctct 84900 taatgtctta cactgagtga tgtttagaat cttaaatttt cttttataat tttagaaaaa 84960 agtatacttt tctttcttat ttttataacc agatccaaac acatttgcat gtagataggc 85020 atttttagtc ttgaacattc atttttactt ttaatcctca cttttattag tttcgtatct 85080 ttttgtattt catttcccct ttcaagatgc cttgagtcct ttctttttag gaatgatgtt 85140 gtgaataaat tatttgataa aatgtcttta cacctgagag tttataagga tagtttgaaa 85200 atcatgtctg taaaataggt tgatctcacc taaaaataat accatataat taaaattaga 85260 attattattg tgttgcttat tgactcttac atatatcaaa aaattgctga gtcttattca 85320 gccagagctt ttacttagta tgatattcat tcctatattt acttttttct cacctttctc 85380 atactttctt ttacttactc agcattttcc tcctttcctc cctcctttct tttcttcttt 85440 ccttcttttc tcttcctttc gtattcctgg tccatcttag catgtaatct ttctttatga 85500 aatggcatgc agataggtct actgttctta cagtaaaaaa cttcaaggcc tcatgtcttt 85560 cccacttctg tttcccattc acaacctttt tagctgattc ttttggtact ttaccactat 85620 atcttgccat agtttatgta cctggctcct acttaatttt ttgtttattt gtgtattagt 85680 cgtaggcatt atttatcgac tcttctctct gaaagatgaa aggttagctc tctttcacat 85740 tcttaactgc ccttttttct taccttgtcc atgtatttct aacccccttt cctcctaata 85800 tgtttatgtc ataattttgg ctagattagt gtatacgatt tacataatta ttactctgta 85860 aatgcttttt atgatctctg agccatgtag tatattatgg ctatttttct ttcttatcta 85920 tttgtatttt tattgttatt acctaaaaaa aaattttcta tgtcttatca ctaattcttc 85980 cctaaaattt cccacaattg tgtaaactta cctcagtata ttcatagata tgagacattc 86040 tatcaatttt accctcttaa agatgcagag ataatgcatt atgtttcatc ccaccatctt 86100 taatgagaag cttccatctt agattaatat tagagaatgt taaaatactc tgcaatcagg 86160 taaggacgct tgaaacttca ttataatgca aaagttttct ttaacacaat aaatattttg 86220 aacccctttt gtgtcttgta ttcataggag ttcagataga ccactttatt tactattttt 86280 tatagagagt gaacagaaat cccatttcta gtcaccagtc cttaatctgt aaatcaggca 86340 gataatctgt aaatgattgg ttgaaatcac attgaattcc actttgtgcc agggacttaa 86400 gttaacgaac aaattattct tacaaaaagg tataaatgta aggttttcat tctgctaaat 86460 atgtttgtca aactgtgttg tgatttgttc tcagtgtgtc atagctacca tagcttttgg 86520 aatgggcatt aataaagctg acattcgcca agtcattcat tacggtgctc ctaaggacat 86580 ggaatcatat tatcaggaga ttggtagagc tggtcgtgat ggacttcaaa gttcttgtca 86640 cgtcctctgg gctcctgcag acattaactt aaataggtaa aaaaaattta ttgtttttac 86700 tcttgcagat ttctttcttt ctttccatat aaacctcaaa agtgtttgag gctatttcca 86760 gtatcccaag taatttgtga gtgcatttaa agtaaaaaaa aaaaaaaaga aaaataaaac 86820 ctccccaaat ccagaggaca tgtaagaaga acatttgtgg taagagttgc cacttggaga 86880 tgagctaatt tcagcatgcc ttagttagtg tgaggaatta actaaatcag gacaatactt 86940 gggcctgtca cagagatcct atggaatact ttcctaccat tgtgcattaa tgaacaggtt 87000 cttttcctct cctcagatcc tgtcaagttg cgatgtcttc agccatagtt acttcaacta 87060 ccactgattt tgttactgat tctttcttcc catgctacag tggtgattat tccagaggat 87120 ttctctcagt ccctatttga ctcttgttac tatttgtttt cttggttagt tccatgagac 87180 catgccagtt ctccttgact gtgtatgaat cattgtgttg cactgtactg acagactgcc 87240 gtaagtcaat attaagtgtt cagtatctaa gtgcaggaga acctttctac ttaagtactc 87300 aacaagtagt ttgttggcac ttaagttcta tgagattttt tgttgtaaag gaaaacatta 87360 tcttgcaaag attttggggc agcatttacc aatactttgt tccttcatcc gtaggaaaaa 87420 gaatctcagg agaaaaacct atacatggta accaatgggg ctgccaagct gatgaagtat 87480 tttcagagta cacctttgtg tagctgaata aattgagatc ttgaatggac atattagctc 87540 attttagtaa aatgataaga gagtgcctcc cactacagtt tttgttttta tgcatcatta 87600 aacaatgtgt ttttgattgt ccactgtgtt ccatgaacta tgctatgtgt gggagatata 87660 gtagtaaaga aaagcaaagt acctgcttcc atagaattca gtataatggg aatggtaatt 87720 ctttagagaa tcacataact atggatacat aggcttcatt ttactgttct ccttttgtgt 87780 ttgaaaatgt caacaatcaa aattttgtaa aaaaggaatc atgcaacata tttaaaatta 87840 taactgtgtt aagtgtaatg aagggaaatt gcactgagta gtaagaatat ataatggtgt 87900 gtggtatttc ccaagttaaa aaggtcagat aaggcttcct tgtggaagtg atagttcaaa 87960 tctgaaagaa gaataggaat taattaggta aaaatgtttg atgcaaattt taagattttc 88020 cttctgagta gtcagtagct tttccttctt aacatagaag atgacaaaac catccttttt 88080 ttgtacataa caattcttgt tttcctttag acagttgtat ctgtcaagct tcttatgatc 88140 taatttaaat aattgggata gaacacagct gtacatgtta ctattaaata tggaatatat 88200 caaacataag ttgattccta ccagttctga ttttatttgt gtattttgtt aaaggtactg 88260 aggacattaa tatccagttt tatattgtgc atttgaaggt tcatcaataa atacaattct 88320 tgtttctctg ggtcttaaaa gatattttaa atggttatct cattaagatt taacaggaaa 88380 taacagtgat tcaaatcaaa tagtggtgcc agaaacccat acttgaattt tgggtataga 88440 caggttaccc tttgcatcaa tcctgaggaa actaaaacta taggattaat caggataaaa 88500 aagaattgag caaggattca ggagggatct gtatcatcct ggtgacaacc ctcttctaga 88560 aaaaactaga aagtctaaga ataaatgaag ttgctggttc tcacctggaa aggtcagtta 88620 ctcacaaaat ttttagagtc tatcttatgc cataattcta tcactgagag aagaaacttg 88680 tccagtcatc atgtaatctt catgtaaatt tatgttttta attgcagaat tcataccaca 88740 ggcaaagtcc caatgtctgc atttgctgtt accttaaata gtcaaacccc aaagttattg 88800 taatcttttt ttaacagaga ataatttgca gagtaatctc ggtccggtag atctttcagt 88860 ggatccaaat gattgccatg aatggtttag aattttttta attttcaagt tgtttttatt 88920 ctgtggaata ctggacttat ttttgtagtc ccaaaagaaa aataaatatt tatttatttg 88980 ccgttaagag ttgtagtttt gttttctcaa atttgtcctg acactgacga gattagttaa 89040 atgtaggtca tctgaaccaa atacaaggaa ggaaggaccc agttctgaag agtgtgggca 89100 tttcttttct tgtttttttt tttttttttt tttttttcta taggagggga acgaggtgaa 89160 ctaaacaaac aaaataaagc aaaaaagaac tgatttttat cccttgaggt agaaagaatg 89220 agattacagt ggaccccctt gtctgcattt tcactttcta tgttttagtt actcacaacc 89280 acgtccaaaa tgttaaatag aaaattccag aaataaacaa tttataaatt ttaaatcagt 89340 ggtggctttg agtactgtaa tgaaattttg tgccatccca ctcagtctgc ctcgacttcc 89400 cttagaatca tccctttgtc cggtgcattc acgttgtatt tactccctgt ctgttagtca 89460 cttgttgcag tatcacagtg cttgtgttca agtaacgctt attttactta agaatgaccc 89520 caaagcacaa gagtactgtg cctaatttat aaattaaact ttttcatagg tatatacata 89580 taggaaaaaa cataatacat acaggatttg gttggtacta ttctgcggct tcaggcatcc 89640 actggacgtc ttggaatgta tcccttgtgg ataaggagga actgtatatg gttaacctag 89700 gagctagagt caacagttgg aagagacttt ggggataatt acatggaagg gcatggtggg 89760 tggtcgtttc agatgacaag aatgtttttg aataacggat catttgtgtc ttcagacttt 89820 ccagaactcc ttgagaatta tgcagaggta tttaatcagt cagaaggttg aatagtcaaa 89880 ttattagtga gtgaagtcta ttttgatgag gattttacta atgctgtccc ttagatatta 89940 taagtaaatc gttgttttct tttgaaatat ctgaaaccta gttaacatgg actttcattt 90000 gttcttgtaa agatatgcaa agctatttgg gagattgtca tcatctgata tttgatattc 90060 atgggctttc ttcacagaag actagaaatt aacagagtca tgatgaatta tggctgcatt 90120 gactttaaaa aacaaacacc tccttaatgt tatttaacaa ttttgaataa atttgatatg 90180 gcaaacaaat cagttataat cgattgagaa aggaacttaa ttctaatact tgactggtgt 90240 cccataataa cccataatac taagagacag ttttggaggg cgagaagtcc tgaagagctg 90300 atagagataa aggttcaaat ttgagcttct ttcagtgttc cttacgtcaa tgcttttagt 90360 ttctcataca aaataaaata aagaataacc tttttactgg gaaaaggtaa aaattaataa 90420 attgtagaag cattgtttga agccaaaaag tgtgtgacat gtaaattgaa atgaaaaacc 90480 ttagagtttt tgatactttt tcaaagcagc taaagaattg atacttggac acaggaagaa 90540 ttttttttca aaagcaattt ttataaaatc agaaaaatgt ttacctcttg ttgggggcat 90600 tgactggaaa ggaatacaac agaactttct gagatgctag aaatgttttt ttatcttgat 90660 ggggtgtggg ttttgtagat aatgaaaaat aaacagtaaa aaataagtaa aaaaaaaagt 90720 aagaaagttg ccaatacagt tttacatatt cctgtgatgt ttttaatcga caggcacctt 90780 cttactgaga tacgtaatga gaagtttcga ttatacaaat taaagatgat ggcaaagatg 90840 gaaaaatatc ttcattctag cagatgtagg agacagtatg tattatttat tttatgccaa 90900 tagtatggat ttatggatga tgctctttta agacaacaat ttggctaaat aattatcagt 90960 attttgaaaa aatattttgt tgctgttaca tgtgtgctga atttttaagg ctaacttctt 91020 tgtgtctgag taaactgaag tcaaataatg aagtcccaag tgaatcaatt aatggtgatt 91080 ttacctcatt attttcagga atgaacttaa catatacgtt tctgttcttt tatttaattt 91140 aaaattttgt cttgggtaga atcatcttgt ctcattttga ggacaaacaa gtacaaaaag 91200 cctccttggg aattatggga actgaaaaat gctgtgataa ttgcaggtcc aggtaaagat 91260 ttcttattat agatggacat tctaaaagtc tttctttctc ttccttttca tgtttaactg 91320 aatttttgtt gaatgataag tatttcagtt ttttaaacaa aacaatgaat gtgtttagat 91380 atgagaaagc aaacaatatt aaagtatttt gcttaaaaaa tagataaagc aataaaatgg 91440 tagccctaaa tctaaacata tcaatagtta tgttaaatgt aaatgatcta aaatattatt 91500 taaaggcgta aattgtaaga attggtttaa aaacatgacc ctgttctgta cgttgtccac 91560 aagaaatcca ctgtaattat atagataggt ttaaaaaaga atgaaacatt acattccatg 91620 aaaacattaa tcaaaaggaa gttggagtta ctttaatatc agacaatgga cactttggag 91680 caaagaatat tatcaggata aagaaggata ttatatgatg taaaagaatc atttcaccaa 91740 tgtatcagtc agggttcacc agagaaatag gacgattgat attatggaga tatatatata 91800 tatatatata tatatatata tggggaggga aaggaagaac aaatatgggg agagagggat 91860 gaggcgactg attttgaaga attagctcac gaaattgtgg gggttggcaa gtctgaaatt 91920 tgtagagcag gtcaataggc tggaaactca ggcaagaggt gatgttgcag tcttgaggca 91980 gaatttcttc tctagcaaac ctagtttttg ccctttagtc ctgccactga gtggatgagg 92040 cccacccaca ttattgacaa taatctcctt tacttaaagt caactgatta taaatgttaa 92100 tcacgtctac aaaatatttt acagcaacat ctagattagt gtttgaccaa acaactgagc 92160 atcataggct agccaagttg atgcataata ttaatcatca caaccaagaa gacatcatcc 92220 taaatatata tatatatata tatatatata tctacttaac aaaaagactg acagaactga 92280 aaggagaaat agagaaatct acagttacat ttggtgactt ccagcatctc tcaataatca 92340 ataaaactga cagaccaaaa aatcagtaag aagacagaag aaatgaacag gattatcagc 92400 atgctggatc tcattgacct ttttagaaca ttctacccaa caacagtaga gtacacattc 92460 aagtgcagat gcagtattca tgaacatgga tcatattcag agtcataaaa caaaccttaa 92520 caaatttaag aatcttgtat ttgtatattt tttgactaga atggaattaa actagaaaac 92580 aataacagaa agataacaga aaagtctcta aaccttagaa attaaataac acacttataa 92640 ataaatccat gagtcaaaga ggaagtctca aggcaaatca gaaaatgttt tgaactgaat 92700 gaaatgaaaa tacaaaatgt gtgagatgca gctaatgcaa tactgagaag gaaatttata 92760 gcattaaata cctatgtaat aaaagaagaa aggtctcaaa tcagtaccta agcttacatc 92820 ttaagcaaca agcaaataag agcaaaataa atcaaaatga agtaaacata aggaaataac 92880 aaagaacata agtcaatgaa tagaaaagct atggtcatac cactgctgtc cagcctgggt 92940 gacagagtga gaccctatgt caaaaaaatt taaaaacaaa gcagcatgca gcattcattg 93000 tcagtgaata gaaaatggga aaacaataga gaaaatcaac tcaaaagctc attctgtata 93060 aagatcaaca aaattgatat aaacttctaa caagactgac ggaaagagaa aagacacaga 93120 agaccaatac caggaatgaa agagggaatt tcactacaga cctcccaggt attactaggg 93180 atgataaggg aacactatga acaactcaga acataacttt aataatttag atgaaatgga 93240 tcaatttctt gataatctca agctaattaa acttacagtg aattagataa cctgcatagt 93300 gttacaacca ttagagggat tgaattctat gttaaaaatc tctgaaaata aaatccccta 93360 gcccaaagaa tttcaatgac aaattctacc aaacatttag aagacaaaat aataccaatt 93420 ctatagcatg attccattta tataatagtc tttgaaacat aaaactatac tagagggatg 93480 aagaaaagat cagtggttat tagagattgg gggagggaga aggtatgatt ccaaaggata 93540 gtacaaggca gtattttgga gtgatagatt tatcgtgccc tgattgtgat gggagttaga 93600 tgaatctatg gatatcttaa aatgtgtaga actttacaca tacatacaac caatttgcct 93660 atgttaattg aaaaaataaa ataaaaacaa attatttacc tggtgggtta gctacgtacc 93720 taagttcaat agctgcgtta ctgtaagaca aaagaagcat tattagggat ggagttgttc 93780 tctgtgtaat gacaaatact tcttcactaa gaagacagaa ttgttttatg cacctttaaa 93840 aaaaaacaaa aacaaaaaaa atacaaccaa caaacagtaa cttgctggtg cggtggctca 93900 cacttgtagt attagcactt tgggaggctg aggtgggagg atcacttgag accaggattt 93960 ttaagaccag tctgggcaaa aaaccgagac tgtgtctcta caaaaataaa aaataaataa 94020 aaaaaattag ctaggcatag cattatgtgc ctctagtccc agctactctg gaggctaagg 94080 tggaaagatc gcttgagcct ggaaggttga gactgcagtt gcagtgagcc atgatggcac 94140 cactacactc caggctgggc atcagagtaa gactctgtct cacataaaaa aaataataat 94200 aatgataaaa actagtctgg gcatggtggc tcacacctgt agtcccagtc ctttggaagg 94260 ccgaggcaag agaattgctt gaacccaaga ctttgagaac agcctgggca acatagcaag 94320 accccatctc tatttaaaaa aaaaaacaaa cttaaaaatc cagcaaatac ataaagcaca 94380 aagccgacag aagaggtgga gaaatcaaca aatccaccat caaagtggga gaatttgata 94440 taattttaag ttattggtag ggtaaacaat ccaaaaatta gtacactgta gaaaatttgg 94500 tcaacatagt aataagtttg cttattacta tttatcagta tacatagtat actgatttat 94560 cagatacata gtatatggag ccctagagca agcaactata gcagtgtatc tcaagtattt 94620 ttacttcatg acccacatag caaatgatat gtgtatataa cacactgggc taattgtcag 94680 agttcagttt ctgtccaaaa ccctaagatc tggagtgatt aacctttcag cactcttaga 94740 actcacttgt ttgtagcaca ctgattgaga agcactgaaa gacttcactc ctcaaacata 94800 catggaatat ttctaaaaac tatgtattgg gccgggtgca gtggctcatg cctgtaatcc 94860 cagcactttg ggaggccgag gcgggtggat cccgaggtca ggagatcgag accatcctgg 94920 ctaacatgat gaaacgccgt ctctactaaa aatacaaaaa attagccgga tgtggtggcg 94980 agtgcctgta gtcccagcta ctcgggaggc tgaggcagga gaatggtgtg aacccaggag 95040 gcggagcttg cagtgagccg agatcgcgcc actgcactcc agcctgggca acagagcgag 95100 actctgtctc aaaaaaaacc aaccaactga acaaacaaaa aaactaaaaa acaaaaacaa 95160 aaaaactatg tattagagca tgggttggca aactatggcc tgtaggccaa atctgcatgc 95220 tgttttattt ttttttattt ttttgacata gggtcactac aggctgtcac acaggctgga 95280 gagcagtggt atgatcatag ctcactgtaa cctcaaattc ctgggctcaa gcaattctct 95340 tgcctcacct cagcttccca agtagctaca ggcatgcact accagaccca gttaattaaa 95400 acaaattttt ttttggtaga gacagtctca gtatgttgcc caggctggtt ttcaaactcc 95460 ttgcctcaat cagtcctcct acttcagcct cctaaagtgc tgggattata ggcatgagcc 95520 atcacgcttg actaatgttt ttgtaaataa agttttctca gaacacagcc atgccttttg 95580 tttatgtgtt atgtagggct gcctgagtta agtagttggc tgcaaagcct atcatggcct 95640 ataaagcctg aaatacttac tatctggtcc tttatagaaa gtgttttctg accctgtact 95700 agactagctt gtctcaaaat tcttcaatga atttggaagt tttctcacca cattttctga 95760 ccataatgca cttgagttag aagtaaataa gcagataaac aacaaaatcc tcatgcattt 95820 ggaaattaaa aataacactt aaataattca tattcaaaga aaaaatcaaa ctggaaatta 95880 aaaaaaattt taaacctaca gataactaca ttaatatgca ttaacatttt tagaacttag 95940 ggatagttac aatgatatac attaaaactg gtaagaggct gggtgcgttg gctcacgcct 96000 gtaatcccag cactttggga ggccgaggct gggggatcac gaggtcaaga gattgaaacc 96060 atcctggcca acatggtgaa accccgtctc tactaaaaat acaaaaatca gctgggcgtg 96120 gtggcacgcg cctgtagtcc cagctacttg ggaggctgag gcaggagaat cgcttgaacc 96180 tgggaggcgg aggttgccgt gagccgagat tgggccactg cactccagcc tggcgacaga 96240 gcgacactct tgtctcaaaa aaaaaacaaa acaaaacaaa aaaaaaaact agtaagaggg 96300 cccagtggct cacacctgtc attctagctc tttgggagac tgaggagaga ggatcagttg 96360 aggccaggat tcaagaccag tctgggcaac ataacgagac cgcatctcta caaaatttta 96420 ataacaacaa caaaaaaaac tggtaagagg caacattgaa tagtactttg tgggagttta 96480 ttagcttgaa atactcataa tagaaaagaa aattaatcag ctaagcatct cactaaagag 96540 attaggagaa taaacctaag catagttttt ttcccccaaa cattattata tctggaatat 96600 tgaatgcatt cttattgcta tttcaaagat acttactcta aggaaagcaa ttgaattagg 96660 tagttgaact ctatagtaga ttttctttaa tgagtccttt tgttctcaac ctacttaaat 96720 aattctcatt tgaatttatg atagtttcag atctacccaa agggtgactt aggaatttaa 96780 cttctaaatc tatttaaatg aaaggtttat aatctttttg tcatatttta cagtcgttag 96840 cgtttaacaa tttatagcat aggatttggg tttttttttt tttttcattt taaagaagaa 96900 gtttatttaa gcaagacact tgactaaggg aagactatct tggagttatt attactagag 96960 taatttattt ctacttaaag acagattgcc ccacaagtaa cagctacata aaaacagttg 97020 taaaattgtc cttggtttta caatgataaa tgaaaaacat taaaattctc taattgaaca 97080 aggtatgcaa ggatttttat attgtttttt gctaaaacta tgacagcaaa ataacatcct 97140 ggagtataaa gataagagct gaatgagcag gccactaggg gacaaaggga gtcttttcac 97200 agaaccaatg cttcttttgc ccaccccatc tccatcgaag tcaatctaaa catattattg 97260 gccatttagt taaaaaaaga aagaaaagaa aagcaatatg cttgtggaca tacaccagtt 97320 actttatgtg cagtaaaaga gtaggaaggg gaaggtgaaa gaatagagaa aactatgtag 97380 tcaggatgtg gtggaaccaa attgcaactt tctttttttt tgagacagag ttttgctctt 97440 gtcacccagg ctggagtgta gtggtggccc aatcttggct cactgcaacc tccgcctctc 97500 agattcaagc cattctcctg cctcagcctt ctgagtagct gggattacag gtgcatgcca 97560 ccatgcctgg ctaatttttg tatttttagt agagatgggt tttcaccatg ttggccaggc 97620 tggtcttgaa tgcctgactt caagtgatcc acccgcctca gcctcccaaa gtgctgggat 97680 tacaggcgtg agccactgcg cctggccaaa ttgtagcttt ctaattgaga ctgtcttctt 97740 ggtctggaag agcagagttc tgcagtaaaa taacaggtcc cccttttagt agacatctcc 97800 atgtctgctg ctggaacaca tcagttttgt cttaagcctc acttccaaat gtgcagatgt 97860 gtctggttca ttgattggct gcctgtcaaa ttgaaacctg atctgcctca ttggcaaacc 97920 gtgcccctta caataggctt tcattggttt actaagcggt gtggtgcgtg gctgttcatc 97980 ttaaactgca ccacagttta agatgaacct tcaaatgaac attatccttg ttctcagtct 98040 tgactttcct tgggcttttt gtggaccctg gtgagtgtgg cagtctcctc agctgctgct 98100 tcacaaaaga ggtaccaggt ctgccccgaa tgagtgagcc cctaaacagg accaggagtg 98160 gcagaagaaa gaggcagcaa ctgagatgtg ttttttctaa gctgaaaggc tttttttttt 98220 tttttttttg caacacacct ttaacactaa agtccaatat ttatataatt ggtcaagtaa 98280 gtggagctgt tctagctata aatatggcaa ctctgcttgc tcgtcctatt attgacatta 98340 ttcctttctg tggtctgagg tgcctcccat gaaacttgct tctaggacac taggattgag 98400 aaccatcagc gtaacatatc tgttacgcta caatagttta ttttcatatt ttagctactt 98460 tacatactcg ggtataatga actttattca tagcttctga agcagttggc acatttgaga 98520 tattttttac ttggctaatt gttatgctaa atcttttgat ttctaaagat acatgccttt 98580 gctaagcttt cttcaaatgt tattattttt atttagattg gatcattgct attccatgga 98640 tgactcagag gatacatcct gggactttgg tccacaagca tttaagcttt tgtctgctgt 98700 ggacatctta ggcgaaaaat ttggaattgg gcttccaatt ttatttctcc gaggatctgt 98760 aagtatatat ctgtgaattc ccttcataga tcttctttta cttctattac acttttcttc 98820 agaggtttgc agtattatga ttgtagcttt gacttcagat gggtgactag gaactcatag 98880 agtcttacta agttccagtt aaacactaca ttcattactt tggataaaac ccgtgtgtat 98940 ggcatcttct gctgttttca tgttcaagcc gatgttcagc tctgcagctc agtctggaag 99000 cattgtgtta atttatcaca ttgcatttgg gtgaatccct agactagtct tgcttaggat 99060 aattaggaaa agttaacttt cattgtatca agggacaggt agaacaaaat tgtccttttg 99120 tccaggaaac cattaaattc ttcaaggaaa actttagtta tagggattat tttttaaatg 99180 tctaatttca gtaacaatat ttgggacata tttatttttc cttctgtttc ctatcagaag 99240 tatttaaagt tataagaaaa ttgtggtttt tgcctttact aatgaataaa taatcaatta 99300 aattcagtta cttttttttg gagtgattga tgttccagta ttcttctaaa caaccacggg 99360 tacaaatgtg aataagatag gaccgttgca gtccaagagc ttgttctgta gtcctttcct 99420 ttatatgatt ttttcccctg atttagaagt ctataaagca aagctaagta ttacacactg 99480 ataatggctg aataaatcaa gagcaagaga taggatactt tgcaaatatg catatttatt 99540 aaaaatgtac tttaaaatag agattaaaat tctcgtattg aatgtagaat aggtaagcat 99600 ttatttgtga aatactcgaa tgcttcatgt aaatactttc tgagtttgta tttttagaaa 99660 ggaacatttt ggaggctgag gcaggagaat ggcgtgaacg tgggaggcgg agcttgcagt 99720 gagctgagat tgtgccactg cactccagcc tgcgcgacag agcaagattc tgtctcaata 99780 aaaaaaaaaa aagaaacata tttattaaat tagttgtgaa atatttttaa tgaaatatat 99840 tgaaaacttc tgttgatttt tcatgtactg atgtttttag attctaaatg gagtttaaaa 99900 ttttgtttgt aaatcacaag ttggattaga aatttaatag tagaagtgtt gcctaaggac 99960 tattttaggt gctgtgagtg aaactgtatt ttttataaca agaattttag ttgtaaggga 100020 cagcttaaat ataattgaga tctgtgaaaa tgtattctgt ctctatcacc ttcagaacct 100080 gtgtatctca gttgaatgta taatttataa aaattattct tgttttaatt tggtgtaatc 100140 cagccatatc cagtatcaac aaataagtct aagtaggctc cttgacaaac ttgaactggc 100200 cacaagagag atcagatttc acctattaaa aaaccaaatc agaccactta cactgacagt 100260 ctcttctggg agtcctcaaa ttaagaagtc tatcctttgt gaaatattac actacccttg 100320 ctagataaaa cttttctaaa agtaccactt aatgaaaatc tgtagacact aaatgcaatg 100380 aaaataaggc attgtttttt tttctcccca tttcagtgat cttggtatcc tgggatattg 100440 tttttaaaat tatcgttata attcctttga gaatttagtg aaatgttccc tttaaccaac 100500 ttaggaaaaa ttaatatctt tgtacatgat tttgagctgt aaaataaaca ttttaaactg 100560 ggaataattg gagtttagtt aaagagataa tgtatataaa tatataacat agtagcagca 100620 tataattctg tcttacacaa gatttttctg aatagtataa acagttatgt agcctatcta 100680 ggagtttgtg aatagagttt aaaattttgt tttgaagctg caaatttgat tagaaattaa 100740 acagtgaagt tattacttaa ggaacttcgt tttagctgtc tgaacaactt actgtataaa 100800 aatctttaaa cattctgtat aaatatgtga taagatatgc aatgacctta attttataga 100860 ttagaaaata aaaacacact cattaattta cataactgac agattaagtg aaacttctct 100920 tctgatcacg ttagcagaat gccaaatctt gtcgtggcac tagaattaga cggtagtttt 100980 gataatacat gatttgacta tagacatttg ttgaaactat tggtagtttt aatcactctt 101040 gtaattttca aactatctaa cgggagagga ttatccatcc tgttttctag acaaactgtt 101100 tcatctgaat gaaatatatt cctagagata attatcacta cttcatcttt tggttttatt 101160 ttgcacatag aattatagtt cacaatgact ttctgaagct ctaaagttgc agctgtgagc 101220 ttctttggcc tgtagggact gggaaaaagc acccccgtcc tcccccaagc ccccccacca 101280 aaaaaagtta aagtgttttt aacaatagct gtgggctttt tgtagtttca gaacttagga 101340 gttgcccagg ctggaatgca gtggtgtgat catagcttga tgcagccttg aactcctggg 101400 ttcaagcaat cctcccacct cagcctccag agtagctggg accacaggtg ccaccccacc 101460 cagctatttt ttttattttt taattttttt gtaggtatgg ggtctcccca tgttgccctg 101520 cctgtctcaa actccagggc tctcaggtga tacccaccac ccttggcctc ccaaagcacc 101580 gagagtcact gtgccaggct gagtttaaaa tttcttgagt tggagtttat ggctattttt 101640 tccactagtt attaaacatg tatttttgta taaggcactg tattacattt tgtgggggga 101700 ttcaaagcta aattagatga gacgcatcat ctattatgga agatgttact taagaagaaa 101760 tgagtgtaat gtagcagaga attagataag ggacgtatga atacatataa atgctgttga 101820 agttctgaag agagagagtg tttagagaaa ttagaggagt ctttgtgaag gtatcactag 101880 aacttcctat ttttgtggaa tatatagtag attttggtgt gatactgtgg atttggacat 101940 tcactcagag aaggaatgag ggaagaatgg tggagaagaa tggcattcac agtacaaaaa 102000 gcaactgtga cttttaaaga agttaatatg gagaagtggc aagtcttttc ttctctcttc 102060 tcttctcttc tctcttcttt ttcttttttc tttttttctc tgtcagatac cgttgtaaag 102120 actttgcttt taccggaaac tgatacgttg ggtcatgtac cctggccagt cagttctctt 102180 tattctaaca cttagccgat cagttagatt tccacattcc atgatatgtc agttttggtg 102240 acccttattt ttccacctgg tttataaagg gaaagaatgt gatatgtcac ccaggctctg 102300 gagtacagtg gcatgatcat aggtcacagc agcctcaaag tttccagttc aagcgatcct 102360 acttccttgg cttcctgagt atgtggcact acaggtgcat gccaccatgc ccagctaact 102420 tttttgtaga gacagggtct ccctatgttt cccaggctgg tcttgaaccc ctgacctcaa 102480 gtgatccgcc caccttggct tcccaagata ttggcattac aggcatgagc cactgtgccg 102540 gcctgaaaat ttctcttttg agatggcatc ccacagaagt atacctgctt agagctaaca 102600 ctggtaaaaa gactatttaa ccctattgcc ttattttact gtagttgaga ttgagttaaa 102660 ctgaaagctg aatgacctgt cctaggtcat actgttactt tgtgccagag tcaggatgag 102720 caaatggatt tcctgcctgc tagtctagtg tcttttctat ttattgtgct gtaacataca 102780 gttttaaatt tgtattttta tgcccaatgg acatggtagc tcacacctgt aatttcagca 102840 cttttgggaa gccgaggtgg ggggattgct cgagaccagg agttcaagat gagcctgggc 102900 aacatagcga gactccgtct ctataaaaaa aaatttaaaa attagctgag tggtgatgtg 102960 tgtgcgtgta gtcctccttg tgggaggttg aggtgggagg atcgattgaa tctaggaatt 103020 caggactgca gtgagccatg attacaccac tgcactccag cctgggtgac agagcaatac 103080 cctgtctcga atgaatgaat gaatgaatga atgaatgaat gaatgcccaa atccgtaagc 103140 tatgttctgt atagcagctt tttcatcata ggcagttttt actcttatca gtggacaacc 103200 tacaaaatta actaaacact taaacaatta acagaggagg ccttgttcag agtgagaaat 103260 cattaagcat ttgttgttga aatttcttac tgtactctgt tttaattctg tttttttttt 103320 tttttaatgt tacttgtttt agtttggatt cctagttgaa aagggaatat gattccttta 103380 aaacaaagat actctgcttt aaagcaaagg tatatcatcc tcttcatggt gattgccatg 103440 gaaacaagac aatgtaaatt tattcaaata gtacacagtt tttatagtta ttgatcatga 103500 ggggaaggga cagttaatcc ctactgatca gataaaacct cattgtttca tactaataaa 103560 tggttttttt atgcttatga aaggaaaagc cagaagtgta atttttagtg tttagagagc 103620 tagtgattct agttagggaa cttaatacct ttgaagttat tagtttgcaa gcaatagaat 103680 ctactactac caaggtgacc cctagcagat gtagagtacc attaacaagt gttccaggga 103740 aggaaagcca actagatacc aagtcatgct ttttactctt agattaagaa attcaggttg 103800 agttaaagga tcagctgtta actaataaaa agcagattaa tattacagag ccaggctctg 103860 tcctggttat ggacttaatc ttcacagcat cctcaagaga taaaaatgaa tatacctgca 103920 tattagatga ggaaatagaa gataagtaac ttgccagagc tatgacgtga actcaggtaa 103980 tgtagcttaa gagcccccac atgtatgtat attgggtgtg tgtgtggagg gggtgcgtgt 104040 gagtgcttgt gcatgcgtgt ggtataataa gaaaaaatta gcatttatgc ctgtaatccc 104100 agcactttgg gagaccgagg cacgaggatc tctcaacccc aggagttcaa gaccagtcta 104160 ggcaacatag cgagacccta cctctacaaa aaaagtttta aaaatattag cgggcatggt 104220 ggaatacacc tgtagtctca gctgcttggg acgctgaggt gggaggatcc ttgagtccag 104280 gagattgagg ctacagtgag ctatgatgac acctctgcac tccagcttgg gtgacaaaga 104340 gagaccctgt ctccaaaaaa aaaaattaga actagttatc tggaggcctg tgttctagtc 104400 ctagctttag tacggctaca cagtgacaca ttaggctacc atttaacatc tttgaacctc 104460 tgataatttg ttaacaatat gggtaaaaat gactaagata aatcaaagag ctccagcatt 104520 ccctccagct ctgaaattct atgatgtttt atcttatttt acttacaaaa ataaattata 104580 ttatgtatat ttaaagtata caatttgatg ttatgggtta cctatagtaa aatgattact 104640 ataatgaaac taattaacat atccatcatc ttatattgtt aaccattttt ttgtttttgt 104700 ggcaaaagca gctgaaatcc actcatttag caggaatccc aaatacagtt cagttgtatt 104760 aattgtaatt ctcatgttgt acattcgatc tctagacttg tttatgctac atatgtttga 104820 cttttaaaca ttctactcaa atcaacccta agtcagggtt agcacagaca ggacttgtta 104880 acaaggtaga aggtgccaca ttgtacctgg gtgtttatat ttctctaaat cttgttctga 104940 tcatatttta ataaatataa tcatcaggac accaaaattc attccttagc tattaaaaaa 105000 ttctattcta ttttattgtt aagatttagg agagcatggt acagattctc ttaactatac 105060 ctatcagaag cctatgtttt aagtccaatg tataggcact gctctgtttg tctctggtgg 105120 gaacttaccc tgctttacct aatttcatcc tagcttcctt tttgtgaaag atcacccttg 105180 cttagcctat tttttggcaa atctacacct tggaaatagt agtaaatgac ataagcatat 105240 taatatttat gatgtgattt atttttgttt tcaagtcata tactggggaa gattctcaaa 105300 tattaaaaca atgtatcttt acatttatgt atgtcgttct tgttctgttt tagaaggctt 105360 gtatttgcat ttttaacatt ccaaaaggta aacctgtaat cataatgttt tcatcaattc 105420 aataaaacca ttacgtttgt aatagagagc cctatagttg ccttagttaa gtttgctgca 105480 actcatttta tatattcttt taattttgat ccctggattt ttaattgatt attaaacctt 105540 cattaggata tatatgaaat gtaaaaatat tgagttataa tctaccgttt tctaaaattt 105600 tatactgcat ttttatatag aaattcaaat tgctcataat cattctagtg aatttaagta 105660 gaaaggtatt tattactagg tattaaatgg cttataatat tgttgacaag gttccactgc 105720 aaaatagttc accaagggag ctgtggcctc ttctgtgatc aagaagccat ctgtcaactt 105780 gggaagcttc cactatagca cctaacccca gactacattg agtaggaagc tgtaataatc 105840 aggaagcttc tacctttgca tgctctgcaa accaacgtga acctgctgta atttgtaacc 105900 acaaaatgga tgcctgttga tacttacgaa gctcatcatt gtatgctggg ttctttgcta 105960 atactttctt ataaaaatta aatacctcca caatcatgca tgctagcaga aacagcagag 106020 gagtagcctt agcctcactt cctgcttata cctgtcatgc aaatatacag aacccagaac 106080 cctagctgaa agggagtttg agaactagta tttgtattgt cccagattct gcagtggaag 106140 aattcatagt ggatggaagt tagaatgacc cttgaattac aatcggccac attcatcaca 106200 aatacattaa ataagagtaa tttgccataa agctctatgt ttgtatactt ctttgttttt 106260 tttttttttt tttttttttt tttttgagac agggtctcac tctgttgctc agtctgtagt 106320 gcagtggtgt catcatagct cactgcagtc ttgatctcct gagctcaaac gattctcctg 106380 cctcagctcc tgcttcagcc tcctgagtag cggaacaaca ggtacacacc accacacttt 106440 gctaattttt tattttttat tttttgtaga gatgtgggtc tcactgtgtt gcccaggatg 106500 gtctcgaact cctgggctta agtgatcctc ccaaagtgtt gggattacag gcatgaacca 106560 ctgtgcctgg cccatatact acatatattt aaaagtagta tttaaatgtg taggatgaat 106620 gaaagaggca gtaagagaac aaagtgaatg aaaaagtatt tctatatgaa gtgaaagcag 106680 gagagtcctc tctgttagag aacaacagaa ttgcatatga cagactagct ttcttaatat 106740 ttctagaact tgatggctgt gaagagcgtc ccgtaggaat tctcccttca cttaggaaaa 106800 catacctcaa aaccatcagc tgtttagcat gcacctgctt ttcctggtat atctcagtga 106860 agcagctaaa ttgtaaatga ttaagtaaac tttgcagtgt atcatgtgca aaagcacagt 106920 aaaaacaaaa atgcattgga agctgtgagt tgttgcactg cactcatgga tgaatagctg 106980 ttggttcgca ttgcgttttt ttgttttgtt ttgttttgtt tttttgagat ggagtcttgc 107040 tctgttgccc aggctggagt gcagtggcgt gatctcggct cactgcaagc tctgcctccc 107100 agattcacgc catcctcctg cctcagcctc ccgagcagct gggaccacag gtgcccgcca 107160 caacacctgg ctaatttttt gtatttttag tagagacggg gtttcaccat gttagccatg 107220 atggtctcaa tctcctgacc tcgtgatctg cctgccttgg cctcccaaag tgctaggatt 107280 acaggcatgc cgcattgcgt tttatataat tctcatggtt ctagtctcga gctgtaggat 107340 tttgatcact gtttcaaaca ataatgtgag tttgctaaga ggtctaaata acaaaagcta 107400 agtgttccaa acacatatcc aaacctatac actgggcaat gcatctgaat tatatgtgaa 107460 atttcctgcc attatttaag acacaaaagg aacattattt tgataatgta tttatttgtg 107520 agtggagtgt tcagaatgag cacgatgggt ataacatttt tgtaggtttt taaagttgaa 107580 atttagtgta aatccaaaga atcaatagac aagtctgtgt tttacttaac ctatatgttt 107640 aaattagcat ttttagatac tgattttatt cctaatttca gaattctcag cgtcttgccg 107700 atcaatatcg caggcacagt ttatttggca ctggcaagga tcaaacagag agttggtgga 107760 aggctttttc ccgtcagctg atcactgagg gattcttggt agaagtttct cggtataaca 107820 aatttatgaa gatttgcgcc cttacgaaaa aggtaaacgg tgtaggagtc tgcctgtttg 107880 acttaatttt gtttcccact ccacattaaa agatcctttt tgcttttaat agggtagaaa 107940 ttggcttcat aaagctaata cagaatctca gagcctcatc cttcaagcta atgaagaatt 108000 gtgtccaaag aagttgcttc tgcctaggtt catttttcag tttttttctt gtaacttctg 108060 cattttttgt tgctatttat gtgattcaaa ttataccagt ttataggcct ctcacaagta 108120 aaatgaatta cctgtttgtt tttgtatgcc tattttagtc agtttggggg aagggatctg 108180 tgaggaaagg ataagtcata gagcactttt cttttttaag agacagagtc tctctgtgtt 108240 gctcaagctg gagtgcagtg gtgcgatcat agcttactgc agcctcgatc tcgtgggccc 108300 aagtaatcct cagccacctg agtagatggg actacagaca tgcactacta tgcccagcta 108360 atatatttta attttttgta tagagacagg gtcttctagt gcttcctagg ctggtcttga 108420 actcctgagc tcaagtgatc ctcctgcctc agcctcccaa actactggga ttacaggcat 108480 gatccaccgc tcccagccag aacattttct tggttgatgg gaagtagctg accatggtat 108540 ttagaaaact tctttctcat cgattaaaga agcagtactg aaatcaatgc ggaggaatcc 108600 atatatcata tttacttctg gtgtgtagaa gtggaaaggg aatacatttg ttgcttactt 108660 ttttgtacct ttacatgtga ttgatcactt gtgagttttt tctttcaaac atcttaaagc 108720 ttccagagct ttttctagaa aaaaaaatca gttttaagaa tcaccagttc taaaagggta 108780 atatcttatt catctttctg agaatggagt atcatgattc atgaattaga tacttgcatc 108840 ttaacatttg aaataattta attttattat tttttagttc gaaaactgta tcttcgggca 108900 ccaaagagca ttgttataat caagtaccag ttgaattaag tacagagaag aaggtttgtt 108960 ttaaagaaat tgttctgatt tatttcattc tttattgatt caaattctgt ttaaaatttt 109020 atattttaat tcctttccaa ttaaagagaa aatggcatat ataacaaagc ataaaattcg 109080 gccagggaag tgatgtgaac agactaaaat ttattgtata taatttctgg ggctaataaa 109140 gaattggagg tatttgagaa aggaattaat ttgggttctt ttaaacctat ctgctaactc 109200 atttggctta gagtagtcac atgttataat acttatagtt gatcaaaaaa ttgattccta 109260 agtgttctta ttaaagacac acacacacac acacacacac acacacattc tctctctctc 109320 tctctcacac acacacacat gcacacacac ttatgtactt tcttgctttt tttgacctaa 109380 gatcttagat aactattaca gattaaatac taatccactg gcagacttca gctaattaga 109440 acactggaat aataggcaag catagtgaat tacattttct ggtgaacttt ttctgcttta 109500 ttgaagtatg cagaatgtaa atgaattgtt tttataactt tggcacttgc tgtatcttag 109560 aacattcttt tgatgattta ttttctgtag ttttgggaga gataagacat tggaatgcgt 109620 ttctaactac ctttagaact ttagaaactg ataatttagg aggttatttt caggtgatta 109680 atttgacagc ttgattaggc aaagaaaaaa ttgtgatttt gagatttttg tttcttattt 109740 tcttcacatt taaaagtttt ttgaaacttt ttttaatgga cctttatatg tttaaatgca 109800 gtctaacttg gagaagttat attcttataa accatgtgat aagatttctt ctgggagtaa 109860 catttctaaa aaaaggcaca gagttccata tttctatgtt ctatacttgc tttatgagta 109920 cttttttttc taaagagaaa gaactgtcag atgttgggct atttcattgg caaaaggaag 109980 ttaaatttaa aacataagct tttcagtatt agaatgatca aagtgagcta taaaagaata 110040 atgttaattt aatagctaac acttcttgga tattactgtt tgtcaggcat tatgttaaat 110100 gctaagaact ttatatgtga tatctcattt aattcttaca agagtctaac agctgttact 110160 atttatcgcc attttatagt tgaagatacc aagggttaag aagttgacaa acttgttcaa 110220 gagcatacag ctaatggccg agctggcttt caagtctata tttgtctacc tctagcatca 110280 agacactatt tatttttctt tgtatgaaat atatacaggc atactttgtt ttattgtgcc 110340 tggctttatt gtgacttgca gatattgcat ttcttataaa ttgaaggttt gtggcaaccc 110400 tgcgtcaaac aggtcatatt agccccattt tccaatagca tgttctgttg tcatgtcttt 110460 gtgttatatt ttggtagttc ttgactggcc attcaccatt tctctccctc tcctcgggtc 110520 tccctgttcc ctgagataca acaaaattga aattaggcca attaataact ctataatagt 110580 ctctaagtgt gttttttttt ttttcgagac tgagtctcac tctgttgttc aggctggagt 110640 gcagtagcac aatctcggct cactgcaatc ttcgcctccc gggttcaagc gattctcctg 110700 tcttagcctc ctgagtagct gggactacag gcgccccccg atcatgtctg gctaattttt 110760 gtatttttag tagagatggg tttttgccgt gttggtcagg tggatcttga actcctgaac 110820 tcaggtgatc cgcctgcctt ggcctcccaa agtgctggga ttacaggtgt gagccgctgt 110880 gcctggccca tctctaagtg tttaagagaa aggaagattc acatgtctct caatttaaat 110940 caaaagctaa aagtgattag gcttagtgag gaagccatgt cgaaagctga gataggccaa 111000 aagctaggcc ccttgcacca aacagttagt ttgcaaaggc aaaagttcct gaaggaaatt 111060 aaaaatgcta ccccagtgaa taaaacaatg ataagaaagc aaagcaggct ttttgctgat 111120 atggagaaag ttttagtggt ctttatagga gattaaacca gccacaacat tcccttgagc 111180 caaagcctaa tccagagcaa agccctaact ctcttcaatt ctctgaaagc tgagagaggt 111240 gaggaagctg cagaataaaa gtttgaggcc agcagaggtt ggttcatgag gtttaaggaa 111300 agaagccatc tccataacat aaaagtgcaa agtgaaacag caagtgctgg tatagaagct 111360 gtagcaagtt atccagaaga tctagctaag atcatcgatg aaggtgcctg cactaacaga 111420 ctttgaatgt agaccaaatg ctttctacca gaagaagaag ctgtctagta ctttcatagc 111480 tagagagaag tcaatgcctg gcttcaaagc ttcaaaggac aagctgactc tcttgttaga 111540 agctgatgca gctggtgact ttaagttgaa gccagtgctc aattagcatt ctgaaaatcc 111600 tagggccctt aagaattatg ctatatctac tctgcctttg ctacatacat gtaacaacaa 111660 agtcttgatg atacctgttt acagcatggt ttcctgaata ctttaagccc attgttgaaa 111720 cctgcttaga caaaagattc ctttcaaaat gttattgctc attgacaaca cttagtcacc 111780 aagagccgta atggagacat acaaggagac taacgttgtt ttcatgcctg ctcgcttaac 111840 atccattctg tagctcatgg atcaagaagt aaattaacct tttaagtatt attatttaag 111900 aaatacagtt tgtaatgctt tagcttctgt agatagtgat tatcagagat gggtttttaa 111960 gaggttttcc agaaaacctt ctggaaaata ttcactattc tagaagtcat gaagaatatt 112020 tgtgattcag gagagtaggt cagaatatca atattaatag gaatttggaa gaagtcgatt 112080 cttattaaaa tcaagagttt agtgatagac atactgagtt tgggatacct gtggagtagt 112140 ccagaagtta atttaaatat atgggcttag tgtacagaag tgagcagggt gcttatatat 112200 gaataaatat tattttaaga tatatttaaa ttttccttaa aataatacct atacttgata 112260 taaaaagtta attggaaatt agtggcttat gacaagcata ccagcccaca ctcttcccaa 112320 acccactttg ctcttattca tagaagctgt catcttcaaa tcttccagct gatttccctg 112380 gcgtgtgcct tcttatttct gaatgacacg cttagagtac tatttttttg acttagcaat 112440 tttagaaatt ttctactcat ctcctattat ggtagatttc ccctccttca ttcctcctcc 112500 aatataatta tatttcgtca tattaataat ttgtttatat atatttttaa tataatatga 112560 taatattgta tttatattat taaaactaca caaatattat atacacacta ctaacccaac 112620 cgtgttatta tggccaccac tacctttatt tttttccttg tgttagtgat tgtctttgtt 112680 ttattttctt ggttttgagt attcctttta ctaattttct tttttcctat ttcaatctct 112740 cattatttgt ttactcattt ggagtgttcc ttgactttta tcccctctta cctagtgaca 112800 ttttaatttt agttatcaaa tttttaattt ctaagaatgc ttcttgttct cttcttgttt 112860 cttcttcccc accagccaaa aatctatgat gttatagcaa ggatcataca ttgtttccca 112920 gtaggttaag aaaccttggt taaaacctgt tgtatcccag taagttaaaa gacgttaacg 112980 tgtcatcttc agtatggatg aaagaatatt ttctttcaaa agcagttggt tgaggaagag 113040 aatgggacaa atgctctttt taaaacacca attttgtgat gaactcaaat tgcaatttta 113100 actttaccat tataatgaat gtatttgatc caaaatgttt aaaatctagg ctgttgtcat 113160 ttaaataaca aattacctta ctggtatcat gaagaataaa tgtttgtact gatttggaaa 113220 gacattctca tttaggggat gaaatagaaa gtcaatgagg agaaagaaaa gcttttatta 113280 tttattttct tttaaatatt ttagtatcat ggtacagtca ccagaaaaag cttacagttc 113340 ctcacagcct gttatttcgg cacaagagca ggagactcag gtaaggcttt tgtaaaaagg 113400 taattagttt atgataggat agttatgatt ctatgtatgc ttaaaattct gtattttgcc 113460 agcattttaa aaattgttct taagctaaga gtctgagttt atatttcagt ttatattcat 113520 tctaaggaaa aatgtggtat ctgaagctct aaaaataaag gactagatct tttaagtaca 113580 ctttaaaaag tgttgtttct ttgttttttg ttcagattgt gttatatggc aaattggtag 113640 aagctaggca gaaacatgcc aataaaatgg atgttccccc agctattctg gcaacaaaca 113700 agatactggt ggatatggcc aaaatgaggt aaactatctt ttgcatgtgt tctatttatt 113760 tccttctaac aaaatagatt tggaaaatat atctaagttg ataatatgac catagcttcc 113820 actgtcacat ctgggaggtg actcagattc cccctgctgc gatgcttatc tctttgccaa 113880 gctttagtac cgtgtttctg tatgaataaa aaccagttac gttttcagca atcatattca 113940 atatttataa aatctaactc attatttacc caccctgcat tttatccaaa tgccgaaact 114000 cctctttttg gattctttat ttttgattat cttaccatca catttgtagt cagaggttcc 114060 taatgcttaa aacctctgat ctgaattttc tctcctccaa tataaaaccc cttcgtcttc 114120 ctcttcttct tcttcatttt tttttttttt tttgtctgaa gacttgtctc actgtgttgc 114180 ccaggctgga gtgtagtggt gcgatcactg ctcactgcag ccttgacccc ctggactcaa 114240 gctatcctcg cacctcagcc tcccgagtag ctgggactac agaacatgcc accatgctca 114300 gctaattttt gtattttttg tagagacagg gttttgccat attgcctagg ctggtcttga 114360 actcctaagc tcaagcaatc ttcccgcctc agtctccaaa gttctggcac tacaggtgtg 114420 agccactgtg cctggcctct ttttctcatt taaatacttt tcataccttt tgtaaaacgg 114480 gttccttgtt gcctgtctat gccttcctcc tccttcttaa tgacaccacg ttaattctga 114540 ctgttttccc ttggcctgtt gcagaagcct cttaactatt aacccttcat tctctctctc 114600 tgtttcatct gatatatgag taccaaacta aatcttcctt tatcatatct tacttctgct 114660 taaatgtttt ttttctagct tagaattcaa ggccctctat ttatgaactt aaacttactt 114720 ttccctctaa gttacagaat ttgaaatggt ttatcttacc tggattgttt atcacttgtt 114780 gaagatccat tttcaacttc catatattta tttacagtgt tgcttctcct tgtagtttcc 114840 ttgattcctc aaaactcctt ttaagaattc ttgaagatct cgctttatta ctatttctcg 114900 ctttattact gtaaagacta tgagaaggtc tttcatgatc ttatcagcaa agtaattcct 114960 ctctcttgaa ttcatagagg actttcagat gaattctaaa gatgcttctg tagcacttac 115020 cacacaatgc tatattttat ttttttgtaa ttagtggtaa acaagtatta ttatatcttc 115080 tagattttaa actccaaata aagatactag ctccttacct ttttgtgtgt ctcctgtagc 115140 acctagcaca atgcctcata aacaggaggt gatcattaaa tatttagaag aaattatttc 115200 ccaagaatag ttgcttggta attgtatttg tcttttactt ccttttaaaa aattgtttct 115260 gtcactaaat tgcatccaat agatgttact tgagtgcaga attttctaat gacattacac 115320 agtgctacat ctgacactaa ttcttttgtt aaaaaataaa tattctggcc gggcgctgtg 115380 gctcacgctt gtaaatccca ggactttggg aggccgaggc gggcggatca cgaggttagg 115440 agatcgaggc catcctggct aacacggtga aaccccgttt ctactaaaaa tacaaaaaat 115500 tagccgggcg tggtggcggg tgcctgtagt cccagttact ctggcggctg aggcaggaga 115560 atggcgtgaa cccgggaggc ggagcttgca gtgagcggag atcgcgccac tgcactccag 115620 cctgggtgac agagcgagac tccgtctaaa aaaaaaataa aaaataaaaa taaataaata 115680 ttctaagacc atactttaat agaggtgttt tttttttttt tttttttttt tttttttttt 115740 tttggtgata gagtctcact ctgtcaccta ggctagagtg cagtggcgcg atctcggctc 115800 actgcaacct ccgcctcctg ggttcaagca attctcctgc ctcagcctcc ggaatagctg 115860 ggactacagg tgcgcgctgc cacccccggc taattttttg tattttagta gagatgaggt 115920 ttcactgtgt tgtccaggct ggtgttgaac tcctgagctc aggcaatcca cccgccccgg 115980 cctcccaaat tgttgggatt acaggcgtga gccacagtgc ctggcccaga ggagatattt 116040 aatgaaaaat aataatcatt agataggcag atttttagaa ggagggcatc gaatgggttc 116100 ttggatattg gacacaataa gaaatattga gctaaaagtc tgaaggaatt ggcagatata 116160 ctgttacagg taaacacttt gtagaagaaa ataatgaatg agactttctt ttgagatttt 116220 cttagcctct tagttgttcc cagttaaagc ctcatatttt tccttttcat gacaataaaa 116280 ataataataa aatcagtaat aaagtgaata tatgagatgt taacctgttc ctttatgaca 116340 atgtcctgtt taccaattaa cagtgtgttt ttgtggtgat gggggcaaga caaatcttta 116400 aatggtggaa agcaaagaaa gaaattataa aacatgatta gttgtattat acgttgtttt 116460 tggttgttgg aaaaactata catttattga gagaatcatt aggaagctga acatcagcta 116520 tattgctgga gtgatactgt ttcagtggtt tcttgacctt tttgttgttg ttgttgttgt 116580 tgttaaacac agaccaacta cggttgaaaa cgtaaaaagg attgatggtg tttctgaagg 116640 caaagctgcc atgttggccc ctctgttgga agtcatcaaa catttctgcc aaacaaatag 116700 tgttcaggta aaatactgtg gtttgcagga gctcttagag aataagcatt ttttgtaacc 116760 atttcaaaag taccctccag aagcaacatt tgctcacttt atttgcattt ccatactgga 116820 cacttagaaa atgaattaaa attgttttta cagtcaatct gttgtaaaaa catgtcagtt 116880 atctactttt aaagatgata ctaaaaagta gttgtccagg ctgctgatgt ctttctattt 116940 cattgggagg ttttgttttt aaattggaaa cattatttta ggttgataaa ttataatttt 117000 acattcaaat gtggtagttg gaatttaaag ctggaaagtt atccttgcta tgagttggtc 117060 aggagctcag ccactttctt ttggtttagc atcttctcta atctccctcc ccttccagta 117120 atgctgtctt ttgatagtaa gtggatttca tattattctc ttcagtttta atagtgtttc 117180 cttcatatcc ttttattatt gcttgttctg ccctaagtga ccatttccag aaatgtcatt 117240 taggattttc tctaaactcc acgtagcaga ctctataatg catactctgc agaaggtgag 117300 gcagtgggag gtagagggga gactactaga ctaggagtca cggaatcagg actttagttc 117360 ttccttacag ttgttcacct ggtgaacctg cacatgtcct ttaatttcct tgggtctcca 117420 tttcctcagc tatacaatgg aaatgacact tcctccccca catccaggaa acaacagatg 117480 acattagaaa atagaagaca tgggataagt ataaaatgtt gaaagagtta aacacattca 117540 aggcaatatt aagggattat tttttacttc caagaagctc ctggaagctt tgggcaggca 117600 cagttggatc ctactttaga aaaatctttc tctaactata agtagaaaac ccttctgctt 117660 tttgaatgta gcatttccct cttttgatat agagtatctt tggcaacttt gaattttctt 117720 tttcatactc ttatataaga catcatgtga aaattcttat ttcttactga gtttttggaa 117780 atgaaattat aatgtcttaa tagtttgaga aagaatatca tacctaccag cggtaattga 117840 gtaagttccc tctctttgga cacttgaaag tagtatcttc tttcatgaat tagtgatatt 117900 atttaataat gaatgagtga tctctcctaa ctccccttca gaagaggaaa atgaagtagg 117960 ggaaaaggta aattccccaa gggataggta tgaaaccttt atgaaccttc tggatagaga 118020 agatgactgc tgatttctgt gattagaaat tatacttggg ttattctgca aattgaaatg 118080 aattatttaa aaaaaaacaa ctttaatgtt tattaagcaa gttttgttat tcatgagttt 118140 cattagcctt ttattttttt tttaaatttt gaagtaaaat ttcttgctgt cacaatacac 118200 attaaaaatt acaaatatga cacatattaa acacattaag atggccgaat aggaaaaata 118260 tgctaaaata tttttatata aatacatttt ttgagaattt tgagaatttc tggaacaaag 118320 taatgatata atccataaat gtacaattaa agagtttaag gatatccaaa atacttggca 118380 aagtaatctg aaataatact cttaggaagg tagggcaaga atgtgattct agtaagcaaa 118440 aatgtgatca aatcgtattc tagtcccagc tactcgggag gctgaggcag gagaatggcg 118500 tgaacctggg aggcggagct tggagtaagc cgagatcgtg ccactgcact ccagcctggg 118560 cgacagagcg agactccatc tcaaaaaaaa aaaaagacta tatgaacatg tatggcataa 118620 atatgtacaa atattattta ttttaaaaaa attcaggggt agggacaggg tagttagaaa 118680 atatctaagg atgttcatga aataatactg gctatgaatg acagttgatg aaaccgggtg 118740 gtgcccatct tattccctcg actcgtgtat atgtttgata tatcccacaa taaaccttaa 118800 aaaaaaaaag atgagtggtc aattatagga agatataaat agaaaaggca ataaggacaa 118860 aagttggcaa agcttaccta agcactcttc agataaaaag acatttttgc taactagatt 118920 tgaatattat agtttaattg tcaaggaaaa tgcctcaact taatctttgt taagagacta 118980 cttaaggcac tatcagaagt tccctcatgg caaggtgcaa tccctcatgc ctgtaatccc 119040 agcactttgg gaggccaagg caggcaggtt acctgaggcc aggagttaga aaacaacctg 119100 ggaaacatag tgagacccga cctctacaaa aacaatttct taaaattagc caggcatggt 119160 ggtgctagcc tgtaatccca gctatttagg atgcttaggc aggaggattg cttgagcccg 119220 gggatttgag gctgcagtga gccatcattg tgccacaata ctccagcctg agtgatagaa 119280 aaaaaaaaaa aaagtgtctt tgttatattc caaacttgtt ctcaactttc aggtgagctg 119340 gcttcctgta taactcttgt ataggacaga acatactggt tggggcaagt gaaactgtct 119400 agttgtatgc ctcataaatt aatgaatttc ctttctaata tatacactga tatttataca 119460 cacatacaca taaaaccaag ctcaatagat gggtagtgca gctctattcc ccaaaaccca 119520 actaccctgt aacaagacac attagacttt tgagattgca aggatgagga ctgaaatgct 119580 ggcctagacc atggtgttgc catagtgggg tgaccagtct gaatagccaa caatgcttcc 119640 tcagtaaata cccattttgt cttggtggga tttctataaa ttgcaaaatg cagctattat 119700 gaagctgtaa aagagaaaca gaaacatgta acacctggga ctgttttatt aggcccaccg 119760 tatgctcaga acatgaaatc tccactgcta gggttatttg attgaaatta tcttttgtgt 119820 tgatgtgaga gtttagctct gagattcttc cacatgtaaa atgtaatccc ccaaagtatt 119880 tggcaagcac attttattgc cttgggtcag ataattgaaa cattaggcat catatatata 119940 gcatgtaaaa agtaaaacag aaacatttat gtttctcacc aagcagtaaa ttagtactca 120000 actaataaat ttcttaaact ccctaataac agaatatgga aacaaaaaat aaatctttcc 120060 aaaagaagag ctcatggaca catttcctca tatatgtata cataatatag tagaacacat 120120 gataaataac ctataaaaat gataccaata tcattcatca agagacgagg ctcttcttta 120180 aattattaat ttcatctgtt acaggtttta ttatgactgt agtatgctgt tttcatctac 120240 cttttatgtg tagttaaaaa aatagttttc tatctcttta cctttatttc agcctttaaa 120300 aagattccat tattttttca ttaatcttgt ttttcagttt ttcccatttt ttcttttaaa 120360 catttcttaa ggaaccatat ttaagatttt atagaatact tagatttcta gttgggatgt 120420 atcatttaaa attagatatg tagagagagt gttatgatat atttccttac gatatattag 120480 tggttatagt acctaaattt gaatagtgat tctgttcatt cattcattca ttcattcaat 120540 attcacttcc aggagattgg ggacttattt aaagacagag tagttcacat tatagttcct 120600 ttttttagtc cttcttattc gttaaagaaa agactaggaa atgtttgtta ttacaaatat 120660 tttattaaaa ttttgtgtgc tctagcatta ttttaccttt taaaatcaat atgttaaaaa 120720 tccaacttct ttttgagctc cccataaaaa gggaattatt tgttgcttat gggtttaact 120780 tgtgttattt ttttcttaat ggctaattat catacatata ttctattatt gtattgatat 120840 tactgatcat ttgtgctaca ttaaaaattc tgtagacaga cctcttttca agtacaaaac 120900 ctcaagaaga acagaagacg agtctggtag caaaaaataa aatatgcaca ctttcacagt 120960 ctatggccat cacatactct ttattccaag aaaagaagat gcctttggta agtgtgactt 121020 tcatgttaca gggaattttt ttagtttact taaacttgtg ttttatcagc tttttagtat 121080 taaagttctg acttgggatc aatttcctcc aaccctacaa taaatctcag tttatcttta 121140 attttaaaag agaatgttgt tttctttttc tgttaagcct ccctgttaag taatagcagc 121200 aagtttagtt tggccatgaa tatcttctag agattgtatc ggggtactga taaacacatt 121260 tgtagctcag ggatactgca tcagccatat tttaaaatgg gactaacagt ttaaaaacta 121320 taaatattca cagtgttaag aaacaatctc aagatgcatt aagaaaaagg aaggtgcaaa 121380 acagaaaaac aaacgtaaac gtgtgtgcat atgcatgctt atatagtcac atattcttgt 121440 atgtgtacaa aaaatacaca ctggatctct gcaagcatag ccaagcaact ggaaatatgt 121500 ttttaaaaac ttgcttttca ttctatctct tctagtactg ttttgatgct ctttgaaaac 121560 aatctaattg ctgtaacaaa tgaccatacg taggccgggt gtggtggctc atgcctgtaa 121620 tcccagcact tcgggaggct gaggcaggca gatcatttga ggccagggat ttgagaccag 121680 ttggacaaca tagggagacc ctgtctttac taaaaataca aaaattagct gggcgtagtg 121740 acgcatgcct gtaatcccag atacttggga ggcggagaca tgggacttgc atgaacccag 121800 gaggcagagg ttgcagtgag ctgagattgc gacactgcat tccaacctgg gcgaccgagc 121860 aagactcggt ctccaaaaaa aaaaaaaaaa aagaccatat gtaatgtttc ttcattgttc 121920 taagataaat ctttaaggct gttgaggttt tttgtataca aaatggagag taagttttaa 121980 tgggatggga caaaatgagg cttacagttg agtttaattt gagttcacat cctgttgaca 122040 ttaagttgat ttggaacaag tgatatggtc caatgcctgc ttttctattg tctgtggttc 122100 catccactag tgcctgtgtt acacacctct tgttcaggtt ttatcattta aaataaataa 122160 gaataaacag tccatagctt atcttactta ctgaataaat gctctaattt gacagtcatg 122220 tttcttaaag ttccttacaa aggccattgc ccaagaaacc aaataattcc attatactat 122280 ttttgaaata gaacacataa taaatgggaa ttttaagttc agtttcttat gtaaacaata 122340 acttctatgt acatgttaaa tatgcctgta tatacctaat ttgaccatgt atgtatagta 122400 gaaatgaaaa cagttactaa gaaaatttgt tattggctcc aaattttctg aattaagtgt 122460 attctaatgc tcagccataa tatggggttt catgtgttag tttatgtatt catggttaaa 122520 aatgtgaaga ctgttatatc ttcatttgtg tcttttggta ttatttggtt gtattttatt 122580 gtgtgatatg gtggtataat tatccttacc tcccaggagt ttgagagggt cttgccagtt 122640 aaccgcagaa ttaaacatgc ttaggactaa ttaatcagga gcaatactac aattagttgg 122700 aggtaatttg aaacctggtt tcaaataacc ctgatattat gcacacatgg tgcacacttt 122760 tctagtagac atttaatgaa agtaatttaa aacctacctt tgaaggatga aaaacattgc 122820 cttaaatgct ctattctgtg aaagtatcaa catttatgca aatacagtct aaattcagac 122880 tttgaaaatg tattgaaaga gaggatcatg aaataagtta gagctgagtg acaaagcttt 122940 ctgagtgttt aaaagaatgt tttacctaat aaatatctga aatgtatttg gagccacatt 123000 tgtttaaaga actgtataaa tatgtagcac tgttcatgtg aagttcaata gtaggaaaat 123060 gctgacagcc cttgtggaac tgtggttatt attattttat gaatagagcc aatttcaaac 123120 acctattaga gtcttctcag gaacatttta tagaatgcat ctggagcctt atgttatctc 123180 taagcatttt aggatttgtc ttcttggaaa ttcatgtaac caaaccacca tgtgttattt 123240 caagtgtata tagtattggg ttacagttta ctatgttttc agaaggttgt gacaactatt 123300 agacttacag agaatgactt ctctgccact aacggctttc taaagtgaat agagaggggc 123360 gaggattgaa ttcttcggta aagctgggtg attttgtttt attcaataca gtataataag 123420 tataaaaagt agaacctata gagagctata atgggggtag ttttaaagaa attctgaaaa 123480 tgaaaaactt aagtaaaggt ttagttcatt gtttatttca cactgagcat ttactacctg 123540 aatgttttgg acattttatt tccatgactg gagtggacac ttttacaact cactgggttc 123600 tttgctgatc tttctctaga agagcatagc tgagagcagg attctgcctc tcatgacaat 123660 tggcatgcac ttatcccaag cggtgaaagc tggctgcccc cttgatttgg agcgagcagg 123720 cctgactcca gaggttcaga agattattgc tgatgttatc cgaaaccctc ccgtcaactc 123780 aggtgagagg catggcctag ctctgcaccc ttaatgactt gatgaagtaa acaagcaatc 123840 cactatattt ttcactgtta acagcattaa tcctttatgc tattatgaaa accttacttt 123900 tgtgattctt tttcttgttt taggaaaaca atctttcttc ccattatcac tcagaggaaa 123960 gtatactgag aaattttttt gttttgtttt gttttttgag acagagtctt gctctcttgt 124020 ctaggctgga gtgcagtggc gtgatcttgg ctcgctgcaa cctctatctc ccaggttcaa 124080 gtgattctct tgcctcagct tcctgagtag ctgggactac aggcgtgtgc caccatgccc 124140 agctattttt tgtatttttt gatagagaca gggttttcca tgttggctag gcaggtctcg 124200 aactcctgac ctctgatgat ccgcccacct cagcctccca aagtgctgcg attacaggtg 124260 tgagccatgg cacctggcca atacactgag aaatttttat tttccttttc agcttaaggt 124320 tacaacttcc ccaccatcca aaacgtgcac tttcattttt tttctaattt ctatctcatc 124380 acttgcaaaa accatatttt tctccacatt cattcccagt agcttcctga ctcctagttc 124440 ttccctaaat ccttctgagt ccttgtcatt ggtttcgctt gagtagcctt tctaatcaac 124500 acagtcattg gtatcagtta ctgtgacatg gaagggacag accaagttct gtgggccgct 124560 acgtagaagg atttcctgtc actttgctgc agaacctcag ctcgcggaga gcaagcccct 124620 ttgcttgccc tgtagaaata ttttaaatta ttatcctttt tttttttaac agaagtaaat 124680 aggagatacg ttagaggatt ttctctccta gatgtgtaaa tacaaacttg gggtcttata 124740 actcaataaa tctgataaat ttcttttgac tgttaggata gagcagtggc cataccaata 124800 gcctcatctc caaagctgca gtgaagatac tttttactac cttaaagtct ttcccatttg 124860 tgaacaactt gtgaacaatt ccccccaaga atttggaaga tcactctctg aaagcacagt 124920 caatactgta cttaaatgga tctgagcaaa aataagtcac ttagaagaca ggattatttc 124980 tagacttgag tgtgacttga ctgaaggtct aaagaacaaa cagctccttc acttccattg 125040 atcacggtgg aagcacaggg aaaggacaga cacggaggca agttggagta gtgctcatct 125100 aagttccagg gatgcggggg agtggccagg ggacttcagg tatagtaaat aaataaccta 125160 tttataagtt atgtcaatgt catgtttgaa atagaaaacc aaatactgca tgttcttact 125220 tacaagcagg agctaaagtt ggtgcatatg gatataaaaa tgagaacagg ccgggcgtgg 125280 tggcttgtgt ctgtaatccc agcactttgg gagacctaga tggaaggatt gcttgagctc 125340 aggagttcaa gaccagcctg agcaacatag tgtgaccccc atctctacaa aaaataagaa 125400 aattagccag acgtggtggc atatacctat agtctcagct acttgggagt ctgagtcagg 125460 aggagtgctt gagctcagga gtttggggtt ataataagct gtgatcatgc cactgtgctc 125520 cagcctgagt gacacccaga gtgagaacct gtctcaaaag gagaaaaaaa aaaaagtaac 125580 agtagacgct ggggactact gaggggaggg aaggaacaat ggttgaaaag gtgggaaggg 125640 acagtggttg aaaaactacg tgttgggtac tatgctcact atctgggtga tgggatcaat 125700 tgtacctcaa acctcagcat cctgcaatat actaatgtta caaacctgcc catgtactac 125760 ctgaatctaa agtaaaagtt ataatttaaa aaaattataa taaaatcaga aaataaaggt 125820 ctgagatgga aaattaaaag accaaagcca cccataagca caataaatcc ctccccccaa 125880 aaaattatat ctattaaaaa aaggtgttgc gccaggcact gtggctcatg cctataatcc 125940 tagcactttg ggaggccaag acgggcagat gacttgactt gaggtcagga gttcaagacc 126000 agcctggcca acatggtgaa accctgtctc tactgaaaat acaaaaatta gccagcagtg 126060 gtggcatgcg cctgtaatcc cagctactca ggagactgag gcaggagaat cgcttgaact 126120 ggggaggcgg aggttgcagt gagccgagat catgccactg cacttcagcc tgggtgacag 126180 agtgagactc tgtctcaaaa aaaaaaaaaa aaaaagacct tgtaccctga caagttttag 126240 tttgtgcagg aatgctagaa tgactcaaga ttggaaaaat ctttaaatgt taattacaca 126300 ataagggtaa aaggagaaaa attacctaat gtcatctgag caacaagaag aagaaatgaa 126360 aggcattaaa aattgggaaa aatttatatt tgacagtatc ttaacaacga attctgcttc 126420 tatatcactt cctagctttc tgatgataac ttcccgtgca gatctgtatg taaggaatgg 126480 acgtagtagt catgctaatc tgagtattta tctgtgtgat acttacgaat taacgatgta 126540 agttaataag ttagcatttc gtgaacctgg ttaataccat ttgctaaggt taaattagcc 126600 aaatcctgaa gtaagctgta aaacatccaa ggtagggtag agaggcatct tatgagaaag 126660 ctggccaact ctcctggtca ccttctaatc ttcctaactt cagaaatcaa ggcagagaga 126720 ggaaaatagt aattactttg taggattaga tttatggttg tcgaaacctt tgtttctcca 126780 gtgcagaatg agatagcgtt ttagggaaag ccaaagactc agatgtcttc ttcatgctca 126840 tcgtgtggaa tttttcttcc tttagaaatg tattgtctct cagggcttaa agcaatttgc 126900 atctttcgat gagacattga gtaataggca atattctctg aaataatttg tgcaggctgg 126960 gcacagtggc tcacacctgt aatcccagca ctttgggagg ccgaggcggg caggtcactg 127020 aggtcaggtg ttggagacga gcctgaccaa catggtgaaa ccccgtctct actaaaaata 127080 ccaaaattag ctgggcttgg tggcacacac ctgtaatccc agctacttgg gaggctgagg 127140 caggagaatt gcttgaaccc ccatgggagg tggaggttgt ggtgagccaa gattgtgtca 127200 ttgtactaca gtctggacaa cagagtgaga ctctgtctca aaaaaaaaaa aatagaattt 127260 gtgcagttcc ccccaccccc tttttttttt ctgttggcat ttttgctatc atttagctgc 127320 cttctttata tcctgaaact tacaggtggt gttggtctag tcagtaagag caaaggcttt 127380 gggaatagat agatctgtat ttagaccttg gctctagcat ctcattgtta tgtgacctcc 127440 atcaagtgac ctaatttccc taatattcaa tttcctcatc tctaagacag ggagttaata 127500 ttgcctctct tatagaattg tgagaaatat agtcatgtgt cgcttgatga tggggatgaa 127560 ttctgagaaa tgtgttgttg ggcgatttca ttttgtggga acctcacagg gtggacttaa 127620 acaaacctag atggtatggc ctactacaca cctaggctgt acggtatagc tcctgtcttc 127680 aaacctgtac agcatgtgac tttactgaac actgtaggca attataacac agtggtattt 127740 gtatatataa acatagtgaa acatagaaaa ggcccagtag aaatacagtg taaaagattt 127800 tttaaaaaag ctgggcatgg tggctcacgc ctgtaatccc agcactttgg gaggccgagg 127860 caggcagatc acttgaggtc aggagttcaa gaccagcctg gccaacatga tgaaactccg 127920 tttctactaa aagtacaaaa attagctggg cgtggtgttg ggtgcctgta atcccagcta 127980 ctcaggaggc tgaggcagga gaattgcttg aacccaggag gtggaggttg cagtgagtca 128040 agattgtgcc actgcacttc agcctgggag acagagcgag actctgtctc aaaaaaaaaa 128100 aaaaaaaaga gataaaaagg tacatctgta cagggcactt accacgaatg gagcttgcac 128160 cctgggagtt gctctgggta agtcagtgag tgagcggtga gtgaatgtga agacctagga 128220 ctgtgcactg ctgtagactt tataaaccct gtgcacttag gccacactca cccctgtgat 128280 acgagtctac ctactgtata acgtacctgc atatgtaccc ttgaaactaa aacaaaagtt 128340 aaaaaattta tcttcttttg ccaataataa attaacctta gcttactgta atgattcttc 128400 tttatgaatt aaaatctttt tactcttttg taataacact tggcttaaaa cacaaacata 128460 ttgtacagct atacaaatat attttcttta tatccttctt ctctaagatt ttttctgttt 128520 ttgattttgt taaatttgtt tttacttttt acattttttt tgttaaaaac caagacaaaa 128580 acccacacat cagcctaggc ctacatgggc tcaggatcat cagtctcact atcttccacc 128640 tccacatctt gtcccaccag gtcttcaggg gcagtcatat gcatggggct gtcatctcct 128700 gtgataacaa tgccttcttc tggacacctc cagaagggcc tgcgtgtttt acagtgaact 128760 tctaaaaaat aataaaatgt atagtatagc aaacacataa acatagtaac atagtcattt 128820 attatcattt tcaagtatta tatactgtac ataattgtac atgctagact tttacacagc 128880 tggcagcaag gtgagtttgt ttacaccatt accaccacaa acacatgggt gatgctttgc 128940 attgtgatgt tacgatggca tgatgtcact aggtggtagg aacttttcag ctccatgata 129000 atctaatgga tacttgttcc tgttggctgc ccgtcgttga ctgcaacatc attatgtggt 129060 gcatgactgt aaattagata ctgttcagaa agctttggca cactggtaat agcaaatggt 129120 ggtggcaaat atgatgatga tgatgatgat gattgaagac atagatggta aaattttatg 129180 gtgtcttaaa agtaccctct aaatatgatt atttttatag tctgtccttt tgaataggca 129240 cttaagaatg tatgaactta ataagtatat aagaaagaat gttccccaaa atatatctta 129300 cagaggcata caatttaaga attcaaacag gttgtaatgg ggtgtgtgtg tgtgtgcaca 129360 cgcgcacgca tgcgtgctca ttcacactaa agaattcttg ggcatatgtt cctgaatgtc 129420 ctaaatggac attctaacat cacttcatta tgggcagagg gaaatggtaa agaaaaattt 129480 catattatat tattcagcca catattgaca gcatctgttt tatttgccta tggtaaagaa 129540 ttgaagcact gttaatttgc tttttaaatc atgtaggcac aaagttatcg aactttagat 129600 ttagaaatga aactggaaat cattacactt tccctttcct atccccaccc tgttttggag 129660 agaaagagtg tgaggcttag agagttataa aactgtttta ataccatgtc taagattaat 129720 aactgaacaa gtttctcttt ttactcgtgt taaagttgta ctgccaatta acttaaaaga 129780 aagaaatatg caatttctaa tcctgatata ggatatgggt atataaactc taacttgatg 129840 agtgaaacaa attaacttat ttataatcag tttcatatct ttatttattg agtgtcttta 129900 aatacccctt acctttaaag taagaaatat taaaatcaag cagaatataa taatgaaaaa 129960 ttcttaagat atacttacta aaaacttatc cttcggttaa tacactgtat gtaggttgta 130020 catacaatat gaaaaagtat atttttgtag cctactttta aatccagaat agaggaggtt 130080 aagaaggttg tgataaccat gagctctttt tttttttttt ttgagacaag gtcttactct 130140 gtttcccagg ctggagtgcc gtggcacaat catagcttac tgcagccttg aactcttggg 130200 ctcaagcaag ccttccactt cagccttcca agtagctggg accacacctg gctaattttt 130260 aagtattttt gtagagatga gttctcacta cattgcccag gctagtcttg aacccctagc 130320 cttaagcgat cctcccacct cagcctgcct aagtgctggg attacaggtg tgagccactg 130380 agcccagccc tcttttattt cttttgatag tacactcata atcattaaac tatcatttct 130440 ggatgtgaga ttgtgctttt ggattcttat tttttcttta taaaatactt tttgttctct 130500 tactggagaa aacattgttg gattataaat gatataacaa ggaatgagga tatacatact 130560 ataataacga ttcagatatg ttattttcat attttattta actgtagcca tgccacaata 130620 atttagagtt ttaaagaaca agtttgattg aaatctaaac tttgtacaat cctgaattga 130680 gaagtttcct gtattttatt atgacacaat atttacctaa aaatagagta attatgaatt 130740 gagaaaacat agctattaat ttcatactct tatttgttaa gtagattttg tctggaaaac 130800 tgttcatatt taaaggagct ttgtaccttt gtattctttt tgtttttcct tgtttatata 130860 attttaaact ctgtttatgg atttgggatt ctaactatgc taaataataa attaaggcat 130920 tgaatgaagt acctagacag tattttgatt aattttattc ccccattctt aatgtgcatg 130980 taactggaaa attaagagtg gcttccaagg gatctactac aaaagtaagg ttaatatgat 131040 ctcttttaaa acactgaagg cgtgtagcca gtgttgtcat taattctgca gtagatattt 131100 tcagcactta tttacatggg aagttagagc agagtaagat gcacctgtaa agctaaatgc 131160 cacttatttg catatatata aaacgcagga tgaatttacc atagaaatat aaagggtact 131220 tatagaaatg tattagaaaa atatatgaat ttttaactta tatctagaag ttaactttat 131280 acatttaact ttaaatcatt aatagtggtt taacaccata agcggatgtt tatgcatcat 131340 cattttatga acaaaagaca ttctaatttt agaaataaag tgattcaaaa gagaataaaa 131400 tatcttactt tttcttttaa aattaatttg tttagcgcat tacatgataa tagctcaagc 131460 ttgtgtgatt tttccctaaa aaattggttt ataaatatta catttatagt atgaagaaat 131520 taatcataca tagtttattt atctaatttc taaataccca tggaagaaaa tgaatttaat 131580 ggaatgtagt tgtgtattac ttggtttcga gtgtgggaaa atttatatgg tctttctaaa 131640 acagcactgt cagtagaaat acaatgtgag ctacatatgc aattttaaat tttctagtag 131700 ccacatttta aaaagtaaat ggatgcaatt tattttgata atataattta attagtctac 131760 tatatttaaa attttatcat ttcaacatgt aatcaatatg aaaattatta atgagatatt 131820 ttacatactt ttttctgtaa taagcctttg taatcaggta tgtactttat atatacaaca 131880 aatcttctga tgctaaattt taactggaaa tacttgatct gtgtttagct tttgtaaaat 131940 ttactgttga acaacgtgga ctaatgtgcc taagtggttc caaacatatt ttaaaatttg 132000 aagacaaata aaagggaact caaagtaaat tgggatacat acatacaaca gaatactgag 132060 ccattaaaaa atgatgaaat agtaaaattg ggggaatttt gatgatacta ggatgatata 132120 atgaccaaga gacaaataca attttagttt ggttgagaga tgtgatcatc acgttgctga 132180 ttttactatg tatagaggtt atcttttcct ttctaagatt ttgaaacttt aattagttaa 132240 cccacttacc tagtttctat tagctgtgta actttctctt cctgtttttt gttttgtttt 132300 gttttgtttt ttgcttttta actgcagtat tttgaggagt cttggagtag caagctaatc 132360 tttggaagaa aggaaaatat aaacctgaaa actaacaatt taaagaacgt cttttcaggt 132420 tgtcatttga aaaatacttg atttctgatc actgatttga attgagtgtc aaatatttga 132480 tatgttttgt aaattaggtg aagatgagtg agtaggttct aaactgcttg ggtttaccgc 132540 actctggagc attgcagaag aatgtgatgt tggaaggaag tgctgaaaca taattattgg 132600 cttgcctata ggagggtgct acataatttt agaaggtgtc aagaaattga cacagtctga 132660 attagttctg ttgagttgca aaaaatgtaa agtttcttga ttctgaaaat aagaaatatg 132720 ttcccagaaa tctcatctag ttaatgtgct tttaaaatca ttgatgtctc ttgttattac 132780 aataatagcc attgaaagaa tcttttttat tagaatgtta tttacaggta cgattagctt 132840 ctatttaaat aaattatttt tatacttgat cttaggcaaa aggccaacaa gtgatcagaa 132900 taaattattt taagagaaaa ctaattataa ttgatatttg gaattggaag cacaatttcc 132960 tttagaacaa ttccacgaat ggttgttttg attctcaagg cagcccacaa aagacagttt 133020 gaaacacaat ttatgcagtg tcaatagtac tgacctgact ttggatcttg gaggcagggg 133080 cttcaggtga tacccgagtg gagtttttac tccatttcca ttccgtaagg ctataggcat 133140 ttgaaagagg aaacttttct ttggcaacct tccaccttcc tttctacaga atatttcagt 133200 atttctagct cataggtttt ctaaaatatt ctctgtaatt tattttgaaa tggagttttt 133260 ttatcgttta cagatatgag taaaattagc ctaatcagaa tgttagttcc tgaaaacatt 133320 gacacgtacc ttatccacat ggcaattgag atccttaaac atggtcctga cagcggactt 133380 caaccttcat gtgatgtcaa caaaaggaga tgttttcccg gttctgaaga gatctgttca 133440 agttctaaga gaagcaagga agaagtaggc atcaatactg aggtattaat tatatataga 133500 attttcataa agtgtcagtt tgttcaattt gcatatccta gtactagaat gctgtatttt 133560 tttgaactgt tatgaattct gatatgatta ctttctctat gtgctacatt tcctttgctt 133620 ttcataaata tgatctgaga aaagtgatta aaaaaaagac agtaaaaggg aggtttagtc 133680 catctgttta gcttattatg tagaatgtca gcttaaattt tacctgtacc tcatattgac 133740 cgtatagcct ggaaaatctt tcggaggtat agttaatgga tttaagcata tggcagttta 133800 tgtagttaat gaaagtgaaa acaaattgta ttataaatac ctcccaaact ggtttattat 133860 cattctatca ttcttcatgc tctgttagta tgatattgaa tatctgaggt accaggatta 133920 ttgttgcttg tggctctgag catttcgtag tgcttttgca tgatgagaga aagattacaa 133980 atttagtatt atgttagatg gtacgtttta ttaaaatcaa atgcttcaaa aataattgct 134040 ctgtgtatgg catgagataa atagcaatca gatatattgt ttaataatat gactctatta 134100 aatgatggca taaatttgaa aatttgacct tcggtatctt ccgggtctaa aattatatga 134160 ctccattata aatattttgg aaatgattaa ctaaaaaatt gtttcaattc ttagttggta 134220 aattcaatgt ggtagtaggt ggtggtgatt attttgtatt agagaattag gaattacact 134280 tagttctaag gtaatcttta taggatgtcc agcaattaaa cccctacttt tttgaattgc 134340 ttaaaaataa gggaactgat ctttttaaat tctgtacttg agttacgtct gtatatatag 134400 tcatgtccta gataatctaa tggaacttaa ttagttggaa atctttatat tgtttataac 134460 tgaactagct ataagaggaa cattaaagaa aacatatttt gagtggaggt aatgaaattt 134520 agcttctaat gctcagcctt ttatttctgt aatctatacc agatacctaa gaccctctta 134580 ttgtttccca gcttcaacct gtcagtatag aaaacggtgt aacttactat tttttctcaa 134640 tattgaagca catttgtagt gaaatattat tttaactata tattgccatt tttgcttttt 134700 ccctatttca gtaacatttt tcgctatttc agtaacatta catgtcaaca agagaatggt 134760 gggtattttg gggggggttg ggtggggaga aattttacta agcttgctag attctaaaag 134820 gtatacctta tttggcccct tttccccatt taggggaaca agggtgttgg ggctgggaag 134880 tagataagag gtgagtaagt catccaaagc atatgtcttc attagcctcc ctgtatgaaa 134940 agctgatttc tgtagagtgt tggaggccta ctttcagaat ctgtcatatg ttaacattca 135000 tcttctctac tgacctgatt tatatccctt agtctatttc attttataat tatgacaaag 135060 gataaagtca ttagaacaaa ttctttttat tagttgacgt attgttgtgt ttatatctct 135120 tgtgtttgtt attaagatgg aagctcaatc atgtccttgt ttaacagaaa ggtgatgtct 135180 tggcattgat aattctgatt caatatccat aggtacatgg tggattcttt aaatatttag 135240 tattctttta tttctggaaa gttttcttaa atgatagttt ttttaaaatt tcatttctat 135300 aaagttttct taaatcatac tttttagtgt tttattccat tacttcatat ttcttcttca 135360 ggaactcctg ctatacatgt atgttggatc ttcattaccc agcttcaata tttttcactt 135420 ttcatgcatt ctttttattt cttcatttct ctttaaattt ttttcttcct tttcaccttc 135480 tatttctctt ttaacataat tgtatttatt tctgtattcc acatagctta gtattcactt 135540 attttaaaat tattttaaaa cgttttttag atttaaaaat tcttttttta tttatatata 135600 catattttat ttttaccaaa ggagcaacac tattaactga agacttctat aatttttttc 135660 ttttatttct gattctttct tcggttttcc ccctcagttt tgaacttttc taattttgat 135720 ttgtgatgtc cttttgtatt ttagataatt ttcctaatgt tttccagctc atttggaaag 135780 gctacagttt tattctgtac ctaagcaagt ctttctggtg tcaaagattt gaccttgata 135840 cttttctttt gctcattttc gtatgagatt agttttcctg tactttcaaa agaaggcgtg 135900 gttcaagatg gctttcccaa tttcacatct gtctctaatg tttttgtgta atgtctaaaa 135960 tatggaaact tggtttatga gatctactct gccattttta tctgggcttt ctcttccttt 136020 tgtctctgtt gtacctgtcc tgcttggttt tgatttaacc ccagtggttt ctcctgaatg 136080 tggagccttc tcctagaagg cagcctcggc tagtcccagg gttcagagta gccagctgct 136140 ctcttcacct aagagaccac tgtggattcc ttgtactcac ttgctattgg cttggacaaa 136200 agccctccca ttttcagatg ctattatcag attaatctct cattaatctg tctttccagt 136260 gtatgcctgt gggctatctt ggggttctct tgttatcaga cacctccctg ctggcctctg 136320 ctttctcccg tacagatgtc agtactgtgc aggtcttaat tgctgttggt ggtttgcccc 136380 tacattctta cagttttagt ttcccaagga tacctttaaa cttggtttta ttgtaaatgt 136440 cgacaatgga ttttgggttt tactatctag ttctgtctta attctggaat tcagaaagat 136500 taaaagctct gttgttgcag ctgctgccac ctcttcccag taccctctcc tcctatgtca 136560 tttttttctt cttatttttc ttgactgtat aagagagaat gtatgacatt tcctgcttga 136620 ccgctgagtt tgattataaa ttaaaataca caatatttta tacaaattgt tttgtagaag 136680 atttatttac agatgctcat tcacaggtaa aattgactta tgaaaatagt tttcatgaca 136740 aatgtatcag gctcggtaac taaatatatg gattgatctt gtttataaat gaaattaaat 136800 gtgaatgtaa cttacatatt tctgtatttg cttacatccg tatgtacaca tataatcagc 136860 aaatgagttg atgtttccta ttcgtaactt aatggtaata gcttggtaac agagttggga 136920 gtattaaaaa gatgtaaaga gccccttaaa attttgttgc tgggaatttt agtgttctac 136980 tgatgaagga aatagacact ggaaggcgtt gtttctatta ggtaacttag atatcatact 137040 gaagacttca aatacttatt gttgacactc aaaagacaca cttagtgtaa gtaagcattt 137100 ccccgctttt cccaatgaaa taagatcatt attataattc cattataaat gctgatgatc 137160 atatttatag aaatatagaa gataagactt gaaatgatat tcgctaccaa ttaatgagtt 137220 tgaagaagaa atcaggatgt gttttgctat tttacattta ttcttattta actccaaaga 137280 attcagtgat gttatgtact attatttcca tttctctgtg aagacgttga agcttaagta 137340 acacgcataa taaggtcata catttagcaa gtggctcaat taaagttcaa acctggttct 137400 gcctggtttc aaagtctgtg ctactccatg gtattaggct acaacatgac ttagggtttc 137460 ttcctctgct ctattgctgt tcagatgtac tcctcttttg gcagagtggg agaaaatttt 137520 tgcaatctat gcatctgaca aaggcccaat atccagaatc tacaaggaac ctaaacaaat 137580 ttacaagaaa aaaaaaaaaa cattaaaaag tgggcaaagg acttgatcag acacatctca 137640 aaagaagaca tttatgtagc caacaaacat atgaagaaaa gctcaacatc actgatcatt 137700 agaaagatgc aaaatgcctt ttctgtatgc caccttatat ccccagtatt tattatttct 137760 aagtcatagt atcttacagt gtatataagt ctcatccgtt cttttgattt tctcttccct 137820 gcttgcaatt gggtacctag gaacaaagtt gcaatcttag ccagtttttt ctttagcctt 137880 tgctgatgtg tgaaaagccc ttttttctac cctggatttc tgtacttaag ctggaacagc 137940 taagttttta ccttttttaa atataaagtt tcagagtctt ctgccaagga tcttttgctg 138000 ttttcctact gttaaatatt tcaaagcctt ttttaaacat agggaatata atcaaacata 138060 gcaagcagct gatgaacaat atctagatag tcttcattat tgaaatggaa taaatggtat 138120 ttttgtattt taggctaaca gacaccttgt accttagata aggccaacct tctcataaaa 138180 tccctcagtt acttttatta ataataacca aattaactct ggattccagg gtgtactcat 138240 gatggaatga tttctctgtc atgttatcct gaggatctag tactctgaga taacataagt 138300 gtatgacact ttaggcttat gaaacactta gctacttaaa ttatttaatt ttttttcatg 138360 tgcagatggt attgtaccca aacactacct ttgtgtgtgt gtgtgtgtgt gcctgtgtgt 138420 gtgtttttga gacagggtct tactctgctc aggctggagt gcagtggcgt gattatagct 138480 cactacagcc ttgacctcct gggctccagt gatcctgcca aagtgttggg attgcaggcg 138540 tgagccacct cacccagcct taaattattt ttttttcaag gatgtttaac ctgagggtta 138600 gaggctcttt ggcacgtgag ctgctgaaat gtgtgtgaaa gtgttgtgca cgtgtatgtt 138660 tctctttttt tctgggaagt ggatctgtag tgattcttag atgagtctat gagacaagaa 138720 acttttattt ttttcattta tttagcgaat gtttgttaag cgtactatgc cttggccact 138780 ctacagggtg ctgattggac cagtctgtct acctaccgtt gtagatgtta gaagctatat 138840 tcttttcaca tgcctaatat aactctttgt gtatgtatac atgcccaggc atgttccttc 138900 ctcagaacat taaattcacc attttggtca actcaaagca agtacaccat gggacacaga 138960 tctgaaataa tgtccagatt tttacttact gaatgaggtg tgttgagtgt ataagactac 139020 atgatgagat ggcaagtaat tgcctgaaga aatgatgtag tgattttgtg tgtcttatat 139080 ttatttactt tttgatccag aaataaatta tatagatacc actattttgt ttggatgggg 139140 gagaaaggat gggtgtgtat tcaggaactt atgttacttt tttgcaacta ataccccttc 139200 tcagtagtac aaagatttga tttctttttc tttctatttc ctacagactt catctgcaga 139260 gagaaagaga cgattacctg tgtggtttgc caaaggaagt gataccagca agaaattaat 139320 ggacaaaacg aaaaggggag gtctttttag ttaagctggc aattaccaga acaattatgt 139380 ttcttgctgt attataagag gatagctata ttttatttct gaagagtaag gagtagtatt 139440 ttggcttaaa aatcattcta attacaaagt tcactgttta ttgaagaact ggcatcttaa 139500 atcagccttc cgcaattcat gtagtttctg ggtcttctgg gagcctacgt gagtacatca 139560 cctaacagaa tattaaatta gacttcctgt aagattgctt taagaaactg ttactgtcct 139620 gttttctaat ctctttatta aaacagtgta tttggaaaat gttatgtgct ctgatttgat 139680 atagataaca gattagtagt tacatggtaa ttatgtgata taaaatattc atatattatc 139740 aaaattctgt tttgtaaatg taagaaagca tagttatttt acaaattgtt tttactgtct 139800 tttgaagaag ttcttaaata cgttgttaaa tggtattagt tgaccagggc agtgaaaatg 139860 aaaccgcatt ttgggtgcca ttaaataggg aaaaaacatg taaaaaatgt aaaatggaga 139920 ccaattgcac taggcaagtg tatattttgt attttatata caatttctat tatttttcaa 139980 gtaataaaac aatgtttttc atactgaata ttatatatat attttttagc tttcatttac 140040 ttaattattt taagtacctt tatttttcca ggatgtcaga atttgattct aatctctctt 140100 atgtagcaca tgtgacttaa tttaaaacct atactgtgac acagagttgg gtaaacgatg 140160 attatttaac tttaagcagt tcaccatcca tttcaaagcc tttgattggc ttttttgtaa 140220 ataaaaataa cttgttaaga aacaaatata tctgtcatag aagaactaga aaatccaggg 140280 aagtgagaaa aatgaaaata aaaatcattc atagttttac tagtagctaa tcacagtcaa 140340 cctcttttgt gtatcccacc agactttttt atattcattt gtttttagtt aaaatataaa 140400 agtctcgtat attcccattt ttctgcattg cattaccaga aggtagtggc gcctattaaa 140460 tatgtgatat gttgttgtcc agccatggct tctgcatttg catgcttttg tgtgtgcatc 140520 tgcaataccc tgtgaatatc ctgtgtgatg gagtggcaag tacgcacaga cacgtctgct 140580 gcatgcctag gtacgaggct gtctccagga gaagcacttg tttgattatt tgagttgcca 140640 attgaatttg ctgctttttt tcatggcttg ccattttcac tgaaaagaat gactaatgaa 140700 aaacgatgat tggttattag atttggatgt ttggcagaca ttttctcaaa attgaactaa 140760 gttggcctct tcacggaaaa caactggtat ttgttgtgcc aatgataaaa ttggagattt 140820 ctagcaaaat gtataatttt ggaaaagttg tgttcctcca ctggaagctt gacagctttc 140880 cttaacataa agacttctct ttctcttcgc tttcactact actactacta attcttcttc 140940 tgattcttct tcttctcctt cttccttctt ccttccttcc tcctcctcct ccttcttctt 141000 cctcttcctc ttcttctttc tctctttcct tccttccctt cccttcccct tccttccttc 141060 cttccttcct tcctccctcc ctccctccct ccctccctcc ctcctttctt tttctttctc 141120 tttctttctt tctttctctc tctctctctc tttctttctt tttctttctc tttttctttc 141180 tttcaagcag tcctcccgcc tcagtccccc aaaatagtgg gattacaggt gtgagccacc 141240 atgcacagcc ttacataaag ccttttctaa tgagatggat agtaattaac aaatgtgagt 141300 ttttgatatt atataaagat tttttctgtg tttcgaagat ccgtataact cagtgaatca 141360 gtatgttctg gatgactaat atgtgatgtt aagaaatcat gactgaggcc gggcgcggtg 141420 gctcacgcct gtaatcccag cactttggga ggccgaggcg ggcggatcac gagatcagga 141480 gatcgagacc accctggcca acatggtgaa accccgtctc tactaaaaat acaaaaatta 141540 gctgggtgtg ttggtgcgtg cctataatcc cagctactcg ggaggctgag gcaggagaat 141600 cgcttgaact caggaggcgg agattgcagt gagctgagac tgcgccactg caccccagcc 141660 tggcgacaga gcaagactcc gtctcaaaaa taaaaaaaga aatcatgact gggtaaaaga 141720 tctgttcaga gtacaagatg gaccaatgga tttgatatat ttgaatataa cagagtatga 141780 aaaagtttat tgatatagtt tcagattaca cactgcaact aatctttaag aaactattac 141840 ttgtccactt tttggtaaaa tttcagagaa caatgtccac cattatctga acaggctatt 141900 aaaatactct tctcttttcc aactacgtgc ctgtgcaaag tcagattttt ttcatatact 141960 tcagccaaaa cagcatatca aaatggattg aatgcagaag tagatctgag aatacagcca 142020 cttttgttaa gccagacaat gagatttgca aaatgtaaac aatgctgctg ttctcagttt 142080 ttaaaaatat gttttttaaa agtatttatg ttaatgtgta cttggtttac tactgctatt 142140 tttaaataaa acaagaaaca tttttaaatg tctgttttaa tttctaaagt ggtagtgata 142200 gatataaccc atattaataa aagctctttg gggtcctcag tgattttttt ttaagagtat 142260 ggaagggttc tcagacctaa gagattgaga aatgctgatg taatgtttta ttataaaggt 142320 gtaccatgaa ttatgtacct tacttcatat tgttggacat taaagttgct ttcagttttt 142380 ttgttttaaa 142390 <210> 7 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> (-)10-20-A ASO for WRN Exon27 <400> 7 aguuuucgaa cuaaaaaaua 20 <210> 8 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> (-)5-20-A ASO for WRN Exon27 <400> 8 gauacaguuu ucgaacuaaa 20 <210> 9 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 1-20-A ASO for WRN Exon27 <400> 9 ccgaagauac aguuuucgaa 20 <210> 10 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 2-20-A ASO for WRN Exon27 <400> 10 cccgaagaua caguuuucga 20 <210> 11 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 3-20-A ASO for WRN Exon27 <400> 11 gcccgaagau acaguuuucg 20 <210> 12 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 4-20-A ASO for WRN Exon27 <400> 12 ugcccgaaga uacaguuuuc 20 <210> 13 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 5-20-A ASO for WRN Exon27 <400> 13 gugcccgaag auacaguuuu 20 <210> 14 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 6-20-A ASO for WRN Exon27 <400> 14 ggugcccgaa gauacaguuu 20 <210> 15 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 7-20-A ASO for WRN Exon27 <400> 15 uggugcccga agauacaguu 20 <210> 16 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 8-20-A ASO for WRN Exon27 <400> 16 uuggugcccg aagauacagu 20 <210> 17 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 8-20-B ASO for WRN Exon27 <220> <221> modified_base <222> (9)..(9) <223> m5c <400> 17 tuggugcccg aagatacagu 20 <210> 18 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 8-20-C ASO for WRN Exon27 <220> <221> modified_base <222> (9)..(9) <223> m5c <220> <221> modified_base <222> (17)..(17) <223> m5c <400> 18 ttggtgcccg aagauacagu 20 <210> 19 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 9-20-A ASO for WRN Exon27 <400> 19 uuuggugccc gaagauacag 20 <210> 20 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 10-20-A ASO for WRN Exon27 <400> 20 cuuuggugcc cgaagauaca 20 <210> 21 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 11-20-A ASO for WRN Exon27 <400> 21 ucuuuggugc ccgaagauac 20 <210> 22 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 12-20-A ASO for WRN Exon27 <400> 22 cucuuuggug cccgaagaua 20 <210> 23 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 13-20-A ASO for WRN Exon27 <400> 23 gcucuuuggu gcccgaagau 20 <210> 24 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 14-20-A ASO for WRN Exon27 <400> 24 ugcucuuugg ugcccgaaga 20 <210> 25 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 15-20-A ASO for WRN Exon27 <400> 25 augcucuuug gugcccgaag 20 <210> 26 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 16-20-A ASO for WRN Exon27 <400> 26 aaugcucuuu ggugcccgaa 20 <210> 27 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 17-20-A ASO for WRN Exon27 <400> 27 caaugcucuu uggugcccga 20 <210> 28 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 18-20-A ASO for WRN Exon27 <400> 28 acaaugcucu uuggugcccg 20 <210> 29 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 19-20-A ASO for WRN Exon27 <400> 29 aacaaugcuc uuuggugccc 20 <210> 30 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 20-20-A ASO for WRN Exon27 <400> 30 uaacaaugcu cuuuggugcc 20 <210> 31 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 21-20-A ASO for WRN Exon27 <400> 31 auaacaaugc ucuuuggugc 20 <210> 32 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 22-20-A ASO for WRN Exon27 <400> 32 uauaacaaug cucuuuggug 20 <210> 33 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 23-20-A ASO for WRN Exon27 <400> 33 uuauaacaau gcucuuuggu 20 <210> 34 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 24-20-A ASO for WRN Exon27 <400> 34 auuauaacaa ugcucuuugg 20 <210> 35 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 25-20-A ASO for WRN Exon27 <400> 35 gauuauaaca augcucuuug 20 <210> 36 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 26-20-A ASO for WRN Exon27 <400> 36 ugauuauaac aaugcucuuu 20 <210> 37 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 27-20-A ASO for WRN Exon27 <400> 37 uugauuauaa caaugcucuu 20 <210> 38 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 28-20-A ASO for WRN Exon27 <400> 38 cuugauuaua acaaugcucu 20 <210> 39 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 29-20-A ASO for WRN Exon27 <400> 39 acuugauuau aacaaugcuc 20 <210> 40 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 30-20-A ASO for WRN Exon27 <400> 40 uacuugauua uaacaaugcu 20 <210> 41 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 31-20-A ASO for WRN Exon27 <400> 41 guacuugauu auaacaaugc 20 <210> 42 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 32-20-A ASO for WRN Exon27 <400> 42 gguacuugau uauaacaaug 20 <210> 43 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 33-20-A ASO for WRN Exon27 <400> 43 ugguacuuga uuauaacaau 20 <210> 44 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 34-20-A ASO for WRN Exon27 <400> 44 cugguacuug auuauaacaa 20 <210> 45 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 35-20-A ASO for WRN Exon27 <400> 45 acugguacuu gauuauaaca 20 <210> 46 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 36-20-A ASO for WRN Exon27 <400> 46 aacugguacu ugauuauaac 20 <210> 47 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 37-20-A ASO for WRN Exon27 <400> 47 caacugguac uugauuauaa 20 <210> 48 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 38-20-A ASO for WRN Exon27 <400> 48 ucaacuggua cuugauuaua 20 <210> 49 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 39-20-A ASO for WRN Exon27 <400> 49 uucaacuggu acuugauuau 20 <210> 50 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 40-20-A ASO for WRN Exon27 <400> 50 auucaacugg uacuugauua 20 <210> 51 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 41-20-A ASO for WRN Exon27 <400> 51 aauucaacug guacuugauu 20 <210> 52 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 46-20-A ASO for WRN Exon27 <400> 52 uacuuaauuc aacugguacu 20 <210> 53 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 51-20-A ASO for WRN Exon27 <400> 53 cucuguacuu aauucaacug 20 <210> 54 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 56-20-A ASO for WRN Exon27 <400> 54 uucuucucug uacuuaauuc 20 <210> 55 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 62-20-A ASO for WRN Exon27 <400> 55 caaaccuucu ucucuguacu 20 <210> 56 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 63-20-A ASO for WRN Exon27 <400> 56 acaaaccuuc uucucuguac 20 <210> 57 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 66-20-A ASO for WRN Exon27 <400> 57 aaaacaaacc uucuucucug 20 <210> 58 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 70-20-A ASO for WRN Exon27 <400> 58 cuuuaaaaca aaccuucuuc 20 <210> 59 <211> 15 <212> DNA <213> Artificial Sequence <220> <223> 1-15-A ASO for WRN Exon27 <400> 59 gauacaguuu ucgaa 15 <210> 60 <211> 15 <212> DNA <213> Artificial Sequence <220> <223> 2-15-A ASO for WRN Exon27 <400> 60 agauacaguu uucga 15 <210> 61 <211> 15 <212> DNA <213> Artificial Sequence <220> <223> 3-15-A ASO for WRN Exon27 <400> 61 aagauacagu uuucg 15 <210> 62 <211> 15 <212> DNA <213> Artificial Sequence <220> <223> 4-15-A ASO for WRN Exon27 <400> 62 gaagauacag uuuuc 15 <210> 63 <211> 15 <212> DNA <213> Artificial Sequence <220> <223> 5-15-A ASO for WRN Exon27 <400> 63 cgaagauaca guuuu 15 <210> 64 <211> 15 <212> DNA <213> Artificial Sequence <220> <223> 6-15-A ASO for WRN Exon27 <400> 64 ccgaagauac aguuu 15 <210> 65 <211> 15 <212> DNA <213> Artificial Sequence <220> <223> 7-15-A ASO for WRN Exon27 <400> 65 cccgaagaua caguu 15 <210> 66 <211> 15 <212> DNA <213> Artificial Sequence <220> <223> 8-15-A ASO for WRN Exon27 <400> 66 gcccgaagau acagu 15 <210> 67 <211> 15 <212> DNA <213> Artificial Sequence <220> <223> 9-15-A ASO for WRN Exon27 <400> 67 ugcccgaaga uacag 15 <210> 68 <211> 15 <212> DNA <213> Artificial Sequence <220> <223> 10-15-A ASO for WRN Exon27 <400> 68 gugcccgaag auaca 15 <210> 69 <211> 15 <212> DNA <213> Artificial Sequence <220> <223> 11-15-A ASO for WRN Exon27 <400> 69 ggugcccgaa gauac 15 <210> 70 <211> 15 <212> DNA <213> Artificial Sequence <220> <223> 12-15-A ASO for WRN Exon27 <400> 70 uggugcccga agaua 15 <210> 71 <211> 15 <212> DNA <213> Artificial Sequence <220> <223> 13-15-A ASO for WRN Exon27 <400> 71 uuggugcccg aagau 15 <210> 72 <211> 15 <212> DNA <213> Artificial Sequence <220> <223> 14-15-A ASO for WRN Exon27 <400> 72 uuuggugccc gaaga 15 <210> 73 <211> 15 <212> DNA <213> Artificial Sequence <220> <223> 15-15-A ASO for WRN Exon27 <400> 73 cuuuggugcc cgaag 15 <210> 74 <211> 15 <212> DNA <213> Artificial Sequence <220> <223> 16-15-A ASO for WRN Exon27 <400> 74 ucuuuggugc ccgaa 15 <210> 75 <211> 15 <212> DNA <213> Artificial Sequence <220> <223> 17-15-A ASO for WRN Exon27 <400> 75 cucuuuggug cccga 15 <210> 76 <211> 15 <212> DNA <213> Artificial Sequence <220> <223> 18-15-A ASO for WRN Exon27 <400> 76 gcucuuuggu gcccg 15 <210> 77 <211> 15 <212> DNA <213> Artificial Sequence <220> <223> 19-15-A ASO for WRN Exon27 <400> 77 ugcucuuugg ugccc 15 <210> 78 <211> 15 <212> DNA <213> Artificial Sequence <220> <223> 20-15-A ASO for WRN Exon27 <400> 78 augcucuuug gugcc 15 <210> 79 <211> 15 <212> DNA <213> Artificial Sequence <220> <223> 21-15-A ASO for WRN Exon27 <400> 79 aaugcucuuu ggugc 15 <210> 80 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> 1-25-A ASO for WRN Exon27 <400> 80 ggugcccgaa gauacaguuu ucgaa 25 <210> 81 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> 3-25-A ASO for WRN Exon27 <400> 81 uuggugcccg aagauacagu uuucg 25 <210> 82 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> 5-25-A ASO for WRN Exon27 <400> 82 cuuuggugcc cgaagauaca guuuu 25 <210> 83 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> 7-25-A ASO for WRN Exon27 <400> 83 cucuuuggug cccgaagaua caguu 25 <210> 84 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> 9-25-A ASO for WRN Exon27 <400> 84 ugcucuuugg ugcccgaaga uacag 25 <210> 85 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> 11-25-A ASO for WRN Exon27 <400> 85 aaugcucuuu ggugcccgaa gauac 25 <210> 86 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> 15-25-A ASO for WRN Exon27 <220> <221> modified_base <222> (4)..(4) <223> m5c <220> <221> modified_base <222> (9)..(9) <223> m5c <220> <221> modified_base <222> (11)..(11) <223> m5c <220> <221> modified_base <222> (19)..(21) <223> m5c <400> 86 taacaatgct ctttggtgcc cgaag 25 <210> 87 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> 15-24-A ASO for WRN Exon27 <220> <221> modified_base <222> (3)..(3) <223> m5c <220> <221> modified_base <222> (8)..(8) <223> m5c <220> <221> modified_base <222> (10)..(10) <223> m5c <220> <221> modified_base <222> (18)..(20) <223> m5c <400> 87 aacaatgctc tttggtgccc gaag 24 <210> 88 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> 15-23-A ASO for WRN Exon27 <220> <221> modified_base <222> (2)..(2) <223> m5c <220> <221> modified_base <222> (7)..(7) <223> m5c <220> <221> modified_base <222> (9)..(9) <223> m5c <220> <221> modified_base <222> (17)..(19) <223> m5c <400> 88 acaatgctct ttggtgcccg aag 23 <210> 89 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> 15-22-A ASO for WRN Exon27 <220> <221> modified_base <222> (1)..(1) <223> m5c <220> <221> modified_base <222> (6)..(6) <223> m5c <220> <221> modified_base <222> (8)..(8) <223> m5c <220> <221> modified_base <222> (16)..(18) <223> m5c <400> 89 caatgctctt tggtgcccga ag 22 <210> 90 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> 15-21-A ASO for WRN Exon27 <220> <221> modified_base <222> (5)..(5) <223> m5c <220> <221> modified_base <222> (7)..(7) <223> m5c <220> <221> modified_base <222> (15)..(17) <223> m5c <400> 90 aatgctcttt ggtgcccgaa g 21 <210> 91 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> 15-19-A ASO for WRN Exon27 <220> <221> modified_base <222> (3)..(3) <223> m5c <220> <221> modified_base <222> (5)..(5) <223> m5c <220> <221> modified_base <222> (13)..(15) <223> m5c <400> 91 tgctctttgg tgcccgaag 19 <210> 92 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> 15-18-A ASO for WRN Exon27 <220> <221> modified_base <222> (2)..(2) <223> m5c <220> <221> modified_base <222> (4)..(4) <223> m5c <220> <221> modified_base <222> (12)..(14) <223> m5c <400> 92 gctctttggt gcccgaag 18 <210> 93 <211> 17 <212> DNA <213> Artificial Sequence <220> <223> 15-17-A ASO for WRN Exon27 <220> <221> modified_base <222> (1)..(1) <223> m5c <220> <221> modified_base <222> (3)..(3) <223> m5c <220> <221> modified_base <222> (11)..(13) <223> m5c <400> 93 ctctttggtg cccgaag 17 <210> 94 <211> 16 <212> DNA <213> Artificial Sequence <220> <223> 15-16-A ASO for WRN Exon27 <220> <221> modified_base <222> (2)..(2) <223> m5c <220> <221> modified_base <222> (10)..(12) <223> m5c <400> 94 tctttggtgc ccgaag 16 <210> 95 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> 16-19-A ASO for WRN Exon27 <220> <221> modified_base <222> (4)..(4) <223> m5c <220> <221> modified_base <222> (6)..(6) <223> m5c <220> <221> modified_base <222> (14)..(16) <223> m5c <400> 95 atgctctttg gtgcccgaa 19 <210> 96 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> 16-18-A ASO for WRN Exon27 <220> <221> modified_base <222> (3)..(3) <223> m5c <220> <221> modified_base <222> (5)..(5) <223> m5c <220> <221> modified_base <222> (13)..(15) <223> m5c <400> 96 tgctctttgg tgcccgaa 18 <210> 97 <211> 17 <212> DNA <213> Artificial Sequence <220> <223> 16-17-A ASO for WRN Exon27 <220> <221> modified_base <222> (2)..(2) <223> m5c <220> <221> modified_base <222> (4)..(4) <223> m5c <220> <221> modified_base <222> (12)..(14) <223> m5c <400> 97 gctctttggt gcccgaa 17 <210> 98 <211> 16 <212> DNA <213> Artificial Sequence <220> <223> 16-16-A ASO for WRN Exon27 <220> <221> modified_base <222> (1)..(1) <223> m5c <220> <221> modified_base <222> (3)..(3) <223> m5c <220> <221> modified_base <222> (11)..(13) <223> m5c <400> 98 ctctttggtg cccgaa 16 <210> 99 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> 10-19-A ASO for WRN Exon27 <220> <221> modified_base <222> (8)..(10) <223> m5c <220> <221> modified_base <222> (18)..(18) <223> m5c <400> 99 tttggtgccc gaagataca 19 <210> 100 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> 10-18-A ASO for WRN Exon27 <220> <221> modified_base <222> (7)..(9) <223> m5c <220> <221> modified_base <222> (17)..(17) <223> m5c <400> 100 ttggtgcccg aagataca 18 <210> 101 <211> 17 <212> DNA <213> Artificial Sequence <220> <223> 10-17-A ASO for WRN Exon27 <220> <221> modified_base <222> (6)..(8) <223> m5c <220> <221> modified_base <222> (16)..(16) <223> m5c <400> 101 tggtgcccga agataca 17 <210> 102 <211> 16 <212> DNA <213> Artificial Sequence <220> <223> 10-16-A ASO for WRN Exon27 <220> <221> modified_base <222> (5)..(7) <223> m5c <220> <221> modified_base <222> (15)..(15) <223> m5c <400> 102 ggtgcccgaa gataca 16 <210> 103 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> 12-19-A ASO for WRN Exon27 <220> <221> modified_base <222> (2)..(2) <223> m5c <220> <221> modified_base <222> (10)..(12) <223> m5c <400> 103 tctttggtgc ccgaagata 19 <210> 104 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> 12-18-A ASO for WRN Exon27 <220> <221> modified_base <222> (1)..(1) <223> m5c <220> <221> modified_base <222> (9)..(11) <223> m5c <400> 104 ctttggtgcc cgaagata 18 <210> 105 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 10-20-B and 10-20-C ASO for WRN Exon27 <220> <221> modified_base <222> (1)..(1) <223> m5c <220> <221> modified_base <222> (9)..(11) <223> m5c <220> <221> modified_base <222> (19)..(19) <223> m5c <400> 105 ctttggtgcc cgaagataca 20 <210> 106 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 10-20-D ASO for WRN Exon27 <400> 106 ctttggtgcc cgaagataca 20 <210> 107 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 1-20-B ASO for WRN Exon27 <220> <221> modified_base <222> (1)..(2) <223> m5c <220> <221> modified_base <222> (10)..(10) <223> m5c <220> <221> modified_base <222> (17)..(17) <223> m5c <400> 107 ccgaagatac agttttcgaa 20 <210> 108 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 12-20-B and 12-20-C ASO for WRN Exon27 <220> <221> modified_base <222> (1)..(1) <223> m5c <220> <221> modified_base <222> (3)..(3) <223> m5c <220> <221> modified_base <222> (11)..(13) <223> m5c <400> 108 ctctttggtg cccgaagata 20 <210> 109 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 12-20-D ASO for WRN Exon27 <400> 109 ctctttggtg cccgaagata 20 <210> 110 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 14-20-B and 14-20-C ASO for WRN Exon27 <220> <221> modified_base <222> (3)..(3) <223> m5c <220> <221> modified_base <222> (5)..(5) <223> m5c <220> <221> modified_base <222> (13)..(15) <223> m5c <400> 110 tgctctttgg tgcccgaaga 20 <210> 111 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 14-20-D ASO for WRN Exon27 <400> 111 tgctctttgg tgcccgaaga 20 <210> 112 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 15-20-B ASO for WRN Exon27 <220> <221> modified_base <222> (4)..(4) <223> m5c <220> <221> modified_base <222> (6)..(6) <223> m5c <220> <221> modified_base <222> (14)..(16) <223> m5c <400> 112 atgctctttg gtgcccgaag 20 <210> 113 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 15-20-C ASO for WRN Exon27 <400> 113 atgctctttg gtgcccgaag 20 <210> 114 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 16-20-B ASO for WRN Exon27 <220> <221> modified_base <222> (5)..(5) <223> m5c <220> <221> modified_base <222> (7)..(7) <223> m5c <220> <221> modified_base <222> (15)..(17) <223> m5c <400> 114 aatgctcttt ggtgcccgaa 20 <210> 115 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 16-20-C ASO for WRN Exon27 <400> 115 aatgctcttt ggtgcccgaa 20 <210> 116 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 17-20-B ASO for WRN Exon27 <220> <221> modified_base <222> (1)..(1) <223> m5c <220> <221> modified_base <222> (6)..(6) <223> m5c <220> <221> modified_base <222> (8)..(8) <223> m5c <220> <221> modified_base <222> (16)..(18) <223> m5c <400> 116 caatgctctt tggtgcccga 20 <210> 117 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 17-20-C ASO for WRN Exon27 <400> 117 caatgctctt tggtgcccga 20 <210> 118 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 18-20-B ASO for WRN Exon27 <220> <221> modified_base <222> (2)..(2) <223> m5c <220> <221> modified_base <222> (7)..(7) <223> m5c <220> <221> modified_base <222> (9)..(9) <223> m5c <220> <221> modified_base <222> (17)..(19) <223> m5c <400> 118 acaatgctct ttggtgcccg 20 <210> 119 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 19-20-B ASO for WRN Exon27 <220> <221> modified_base <222> (3)..(3) <223> m5c <220> <221> modified_base <222> (8)..(8) <223> m5c <220> <221> modified_base <222> (10)..(10) <223> m5c <220> <221> modified_base <222> (18)..(20) <223> m5c <400> 119 aacaatgctc tttggtgccc 20 <210> 120 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 21-20-B ASO for WRN Exon27 <220> <221> modified_base <222> (5)..(5) <223> m5c <220> <221> modified_base <222> (10)..(10) <223> m5c <220> <221> modified_base <222> (12)..(12) <223> m5c <220> <221> modified_base <222> (20)..(20) <223> m5c <400> 120 ataacaatgc tctttggtgc 20 <210> 121 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 25-20-B ASO for WRN Exon27 <220> <221> modified_base <222> (9)..(9) <223> m5c <220> <221> modified_base <222> (14)..(14) <223> m5c <220> <221> modified_base <222> (16)..(16) <223> m5c <400> 121 gattataaca atgctctttg 20 <210> 122 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 29-20-B ASO for WRN Exon27 <220> <221> modified_base <222> (2)..(2) <223> m5c <220> <221> modified_base <222> (13)..(13) <223> m5c <220> <221> modified_base <222> (18)..(18) <223> m5c <220> <221> modified_base <222> (20)..(20) <223> m5c <400> 122 acttgattat aacaatgctc 20 <210> 123 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 30-20-B ASO for WRN Exon27 <220> <221> modified_base <222> (3)..(3) <223> m5c <220> <221> modified_base <222> (14)..(14) <223> m5c <220> <221> modified_base <222> (19)..(19) <223> m5c <400> 123 tacttgatta taacaatgct 20 <210> 124 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 31-20-B ASO for WRN Exon27 <220> <221> modified_base <222> (4)..(4) <223> m5c <220> <221> modified_base <222> (15)..(15) <223> m5c <220> <221> modified_base <222> (20)..(20) <223> m5c <400> 124 gtacttgatt ataacaatgc 20 <210> 125 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 34-20-B ASO for WRN Exon27 <220> <221> modified_base <222> (1)..(1) <223> m5c <220> <221> modified_base <222> (7)..(7) <223> m5c <220> <221> modified_base <222> (18)..(18) <223> m5c <400> 125 ctggtacttg attataacaa 20 <210> 126 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 36-20-B ASO for WRN Exon27 <220> <221> modified_base <222> (3)..(3) <223> m5c <220> <221> modified_base <222> (9)..(9) <223> m5c <220> <221> modified_base <222> (20)..(20) <223> m5c <400> 126 aactggtact tgattataac 20 <210> 127 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 46-20-B ASO for WRN Exon27 <220> <221> modified_base <222> (3)..(3) <223> m5c <220> <221> modified_base <222> (10)..(10) <223> m5c <220> <221> modified_base <222> (13)..(13) <223> m5c <220> <221> modified_base <222> (19)..(19) <223> m5c <400> 127 tacttaattc aactggtact 20 <210> 128 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 51-20-B ASO for WRN Exon27 <220> <221> modified_base <222> (1)..(1) <223> m5c <220> <221> modified_base <222> (3)..(3) <223> m5c <220> <221> modified_base <222> (8)..(8) <223> m5c <220> <221> modified_base <222> (15)..(15) <223> m5c <220> <221> modified_base <222> (18)..(18) <223> m5c <400> 128 ctctgtactt aattcaactg 20 <210> 129 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 6-20-B ASO for WRN Exon27 <220> <221> modified_base <222> (5)..(7) <223> m5c <220> <221> modified_base <222> (15)..(15) <223> m5c <400> 129 ggtgcccgaa gatacagttt 20 <210> 130 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 6-20-C ASO for WRN Exon27 <400> 130 ggtgcccgaa gatacagttt 20 <210> 131 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 7-20-B ASO for WRN Exon27 <220> <221> modified_base <222> (6)..(8) <223> m5c <220> <221> modified_base <222> (16)..(16) <223> m5c <400> 131 tggtgcccga agatacagtt 20 <210> 132 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 7-20-C ASO for WRN Exon27 <400> 132 tggtgcccga agatacagtt 20 <210> 133 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 8-20-D and 8-20-E ASO for WRN Exon27 <220> <221> modified_base <222> (7)..(9) <223> m5c <220> <221> modified_base <222> (17)..(17) <223> m5c <400> 133 ttggtgcccg aagatacagt 20 <210> 134 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 8-20-F ASO for WRN Exon27 <400> 134 ttggtgcccg aagatacagt 20 <210> 135 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 9-20-B ASO for WRN Exon27 <220> <221> modified_base <222> (8)..(10) <223> m5c <220> <221> modified_base <222> (18)..(18) <223> m5c <400> 135 tttggtgccc gaagatacag 20 <210> 136 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 9-20-C ASO for WRN Exon27 <400> 136 tttggtgccc gaagatacag 20 <210> 137 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 9-20-D ASO for WRN Exon27 <400> 137 tttcgtcccc caacatagag 20 <210> 138 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> (-)10-20 ASO for WRN Exon27 <400> 138 agttttcgaa ctaaaaaata 20 <210> 139 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> (-)5-20 ASO for WRN Exon27 <400> 139 gatacagttt tcgaactaaa 20 <210> 140 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 1-20 ASO for WRN Exon27 <400> 140 ccgaagatac agttttcgaa 20 <210> 141 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 2-20 ASO for WRN Exon27 <400> 141 cccgaagata cagttttcga 20 <210> 142 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 3-20 ASO for WRN Exon27 <400> 142 gcccgaagat acagttttcg 20 <210> 143 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 4-20 ASO for WRN Exon27 <400> 143 tgcccgaaga tacagttttc 20 <210> 144 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 5-20 ASO for WRN Exon27 <400> 144 gtgcccgaag atacagtttt 20 <210> 145 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 6-20 ASO for WRN Exon27 <400> 145 ggtgcccgaa gatacagttt 20 <210> 146 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 7-20 ASO for WRN Exon27 <400> 146 tggtgcccga agatacagtt 20 <210> 147 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 8-20 ASO for WRN Exon27 <400> 147 ttggtgcccg aagatacagt 20 <210> 148 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 9-20 ASO for WRN Exon27 <400> 148 tttggtgccc gaagatacag 20 <210> 149 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 10-20 ASO for WRN Exon27 <400> 149 ctttggtgcc cgaagataca 20 <210> 150 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 11-20 ASO for WRN Exon27 <400> 150 tctttggtgc ccgaagatac 20 <210> 151 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 12-20 ASO for WRN Exon27 <400> 151 ctctttggtg cccgaagata 20 <210> 152 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 13-20 ASO for WRN Exon27 <400> 152 gctctttggt gcccgaagat 20 <210> 153 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 14-20 ASO for WRN Exon27 <400> 153 tgctctttgg tgcccgaaga 20 <210> 154 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 15-20 ASO for WRN Exon27 <400> 154 atgctctttg gtgcccgaag 20 <210> 155 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 16-20 ASO for WRN Exon27 <400> 155 aatgctcttt ggtgcccgaa 20 <210> 156 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 17-20 ASO for WRN Exon27 <400> 156 caatgctctt tggtgcccga 20 <210> 157 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 18-20 ASO for WRN Exon27 <400> 157 acaatgctct ttggtgcccg 20 <210> 158 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 19-20 ASO for WRN Exon27 <400> 158 aacaatgctc tttggtgccc 20 <210> 159 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 20-20 ASO for WRN Exon27 <400> 159 taacaatgct ctttggtgcc 20 <210> 160 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 21-20 ASO for WRN Exon27 <400> 160 ataacaatgc tctttggtgc 20 <210> 161 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 22-20 ASO for WRN Exon27 <400> 161 tataacaatg ctctttggtg 20 <210> 162 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 23-20 ASO for WRN Exon27 <400> 162 ttataacaat gctctttggt 20 <210> 163 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 24-20 ASO for WRN Exon27 <400> 163 attataacaa tgctctttgg 20 <210> 164 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 25-20 ASO for WRN Exon27 <400> 164 gattataaca atgctctttg 20 <210> 165 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 26-20 ASO for WRN Exon27 <400> 165 tgattataac aatgctcttt 20 <210> 166 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 27-20 ASO for WRN Exon27 <400> 166 ttgattataa caatgctctt 20 <210> 167 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 28-20 ASO for WRN Exon27 <400> 167 cttgattata acaatgctct 20 <210> 168 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 29-20 ASO for WRN Exon27 <400> 168 acttgattat aacaatgctc 20 <210> 169 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 30-20 ASO for WRN Exon27 <400> 169 tacttgatta taacaatgct 20 <210> 170 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 31-20 ASO for WRN Exon27 <400> 170 gtacttgatt ataacaatgc 20 <210> 171 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 32-20 ASO for WRN Exon27 <400> 171 ggtacttgat tataacaatg 20 <210> 172 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 33-20 ASO for WRN Exon27 <400> 172 tggtacttga ttataacaat 20 <210> 173 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 34-20 ASO for WRN Exon27 <400> 173 ctggtacttg attataacaa 20 <210> 174 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 35-20 ASO for WRN Exon27 <400> 174 actggtactt gattataaca 20 <210> 175 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 36-20 ASO for WRN Exon27 <400> 175 aactggtact tgattataac 20 <210> 176 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 37-20 ASO for WRN Exon27 <400> 176 caactggtac ttgattataa 20 <210> 177 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 38-20 ASO for WRN Exon27 <400> 177 tcaactggta cttgattata 20 <210> 178 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 39-20 ASO for WRN Exon27 <400> 178 ttcaactggt acttgattat 20 <210> 179 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 40-20 ASO for WRN Exon27 <400> 179 attcaactgg tacttgatta 20 <210> 180 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 41-20 ASO for WRN Exon27 <400> 180 aattcaactg gtacttgatt 20 <210> 181 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 46-20 ASO for WRN Exon27 <400> 181 tacttaattc aactggtact 20 <210> 182 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 51-20 ASO for WRN Exon27 <400> 182 ctctgtactt aattcaactg 20 <210> 183 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 56-20 ASO for WRN Exon27 <400> 183 ttcttctctg tacttaattc 20 <210> 184 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 62-20 ASO for WRN Exon27 <400> 184 caaaccttct tctctgtact 20 <210> 185 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 63-20 ASO for WRN Exon27 <400> 185 acaaaccttc ttctctgtac 20 <210> 186 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 66-20 ASO for WRN Exon27 <400> 186 aaaacaaacc ttcttctctg 20 <210> 187 <211> 20 <212> DNA <213> Artificial Sequence <220> <223> 70-20 ASO for WRN Exon27 <400> 187 ctttaaaaca aaccttcttc 20 <210> 188 <211> 15 <212> DNA <213> Artificial Sequence <220> <223> 1-15 ASO for WRN Exon27 <400> 188 gatacagttt tcgaa 15 <210> 189 <211> 15 <212> DNA <213> Artificial Sequence <220> <223> 2-15 ASO for WRN Exon27 <400> 189 agatacagtt ttcga 15 <210> 190 <211> 15 <212> DNA <213> Artificial Sequence <220> <223> 3-15 ASO for WRN Exon27 <400> 190 aagatacagt tttcg 15 <210> 191 <211> 15 <212> DNA <213> Artificial Sequence <220> <223> 4-15 ASO for WRN Exon27 <400> 191 gaagatacag ttttc 15 <210> 192 <211> 15 <212> DNA <213> Artificial Sequence <220> <223> 5-15 ASO for WRN Exon27 <400> 192 cgaagataca gtttt 15 <210> 193 <211> 15 <212> DNA <213> Artificial Sequence <220> <223> 6-15 ASO for WRN Exon27 <400> 193 ccgaagatac agttt 15 <210> 194 <211> 15 <212> DNA <213> Artificial Sequence <220> <223> 7-15 ASO for WRN Exon27 <400> 194 cccgaagata cagtt 15 <210> 195 <211> 15 <212> DNA <213> Artificial Sequence <220> <223> 8-15 ASO for WRN Exon27 <400> 195 gcccgaagat acagt 15 <210> 196 <211> 15 <212> DNA <213> Artificial Sequence <220> <223> 9-15 ASO for WRN Exon27 <400> 196 tgcccgaaga tacag 15 <210> 197 <211> 15 <212> DNA <213> Artificial Sequence <220> <223> 10-15 ASO for WRN Exon27 <400> 197 gtgcccgaag ataca 15 <210> 198 <211> 15 <212> DNA <213> Artificial Sequence <220> <223> 11-15 ASO for WRN Exon27 <400> 198 ggtgcccgaa gatac 15 <210> 199 <211> 15 <212> DNA <213> Artificial Sequence <220> <223> 12-15 ASO for WRN Exon27 <400> 199 tggtgcccga agata 15 <210> 200 <211> 15 <212> DNA <213> Artificial Sequence <220> <223> 13-15 ASO for WRN Exon27 <400> 200 ttggtgcccg aagat 15 <210> 201 <211> 15 <212> DNA <213> Artificial Sequence <220> <223> 14-15 ASO for WRN Exon27 <400> 201 tttggtgccc gaaga 15 <210> 202 <211> 15 <212> DNA <213> Artificial Sequence <220> <223> 15-15 ASO for WRN Exon27 <400> 202 ctttggtgcc cgaag 15 <210> 203 <211> 15 <212> DNA <213> Artificial Sequence <220> <223> 16-15 ASO for WRN Exon27 <400> 203 tctttggtgc ccgaa 15 <210> 204 <211> 15 <212> DNA <213> Artificial Sequence <220> <223> 17-15 ASO for WRN Exon27 <400> 204 ctctttggtg cccga 15 <210> 205 <211> 15 <212> DNA <213> Artificial Sequence <220> <223> 18-15 ASO for WRN Exon27 <400> 205 gctctttggt gcccg 15 <210> 206 <211> 15 <212> DNA <213> Artificial Sequence <220> <223> 19-15 ASO for WRN Exon27 <400> 206 tgctctttgg tgccc 15 <210> 207 <211> 15 <212> DNA <213> Artificial Sequence <220> <223> 20-15 ASO for WRN Exon27 <400> 207 atgctctttg gtgcc 15 <210> 208 <211> 15 <212> DNA <213> Artificial Sequence <220> <223> 21-15 ASO for WRN Exon27 <400> 208 aatgctcttt ggtgc 15 <210> 209 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> 1-25 ASO for WRN Exon27 <400> 209 ggtgcccgaa gatacagttt tcgaa 25 <210> 210 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> 3-25 ASO for WRN Exon27 <400> 210 ttggtgcccg aagatacagt tttcg 25 <210> 211 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> 5-25 ASO for WRN Exon27 <400> 211 ctttggtgcc cgaagataca gtttt 25 <210> 212 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> 7-25 ASO for WRN Exon27 <400> 212 ctctttggtg cccgaagata cagtt 25 <210> 213 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> 9-25 ASO for WRN Exon27 <400> 213 tgctctttgg tgcccgaaga tacag 25 <210> 214 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> 11-25 ASO for WRN Exon27 <400> 214 aatgctcttt ggtgcccgaa gatac 25 <210> 215 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> 15-25 ASO for WRN Exon27 <400> 215 taacaatgct ctttggtgcc cgaag 25 <210> 216 <211> 24 <212> DNA <213> Artificial Sequence <220> <223> 15-24 ASO for WRN Exon27 <400> 216 aacaatgctc tttggtgccc gaag 24 <210> 217 <211> 23 <212> DNA <213> Artificial Sequence <220> <223> 15-23 ASO for WRN Exon27 <400> 217 acaatgctct ttggtgcccg aag 23 <210> 218 <211> 22 <212> DNA <213> Artificial Sequence <220> <223> 15-22 ASO for WRN Exon27 <400> 218 caatgctctt tggtgcccga ag 22 <210> 219 <211> 21 <212> DNA <213> Artificial Sequence <220> <223> 15-21 ASO for WRN Exon27 <400> 219 aatgctcttt ggtgcccgaa g 21 <210> 220 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> 15-19 ASO for WRN Exon27 <400> 220 tgctctttgg tgcccgaag 19 <210> 221 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> 15-18 ASO for WRN Exon27 <400> 221 gctctttggt gcccgaag 18 <210> 222 <211> 17 <212> DNA <213> Artificial Sequence <220> <223> 15-17 ASO for WRN Exon27 <400> 222 ctctttggtg cccgaag 17 <210> 223 <211> 16 <212> DNA <213> Artificial Sequence <220> <223> 15-16 ASO for WRN Exon27 <400> 223 tctttggtgc ccgaag 16 <210> 224 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> 16-19 ASO for WRN Exon27 <400> 224 atgctctttg gtgcccgaa 19 <210> 225 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> 16-18 ASO for WRN Exon27 <400> 225 tgctctttgg tgcccgaa 18 <210> 226 <211> 17 <212> DNA <213> Artificial Sequence <220> <223> 16-17 ASO for WRN Exon27 <400> 226 gctctttggt gcccgaa 17 <210> 227 <211> 16 <212> DNA <213> Artificial Sequence <220> <223> 16-16 ASO for WRN Exon27 <400> 227 ctctttggtg cccgaa 16 <210> 228 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> 10-19 ASO for WRN Exon27 <400> 228 tttggtgccc gaagataca 19 <210> 229 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> 10-18 ASO for WRN Exon27 <400> 229 ttggtgcccg aagataca 18 <210> 230 <211> 17 <212> DNA <213> Artificial Sequence <220> <223> 10-17 ASO for WRN Exon27 <400> 230 tggtgcccga agataca 17 <210> 231 <211> 16 <212> DNA <213> Artificial Sequence <220> <223> 10-16 ASO for WRN Exon27 <400> 231 ggtgcccgaa gataca 16 <210> 232 <211> 19 <212> DNA <213> Artificial Sequence <220> <223> 12-19 ASO for WRN Exon27 <400> 232 tctttggtgc ccgaagata 19 <210> 233 <211> 18 <212> DNA <213> Artificial Sequence <220> <223> 12-18 ASO for WRN Exon27 <400> 233 ctttggtgcc cgaagata 18 <210> 234 <211> 27 <212> DNA <213> Artificial Sequence <220> <223> WRN_Exon26_Fw <400> 234 ctcagagcct catccttcaa gctaatg 27 <210> 235 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> WRN_Exon29_Rv <400> 235 caatctgagt ctcctgctct tgtgc 25 <210> 236 <211> 25 <212> DNA <213> Artificial Sequence <220> <223> WRN_Exon25_Fw <400> 236 ctggcaagga tcaaacagag agttg 25

Claims (29)

  1. 인간 WRN 유전자의 제26번 또는 제28번 엑손의 스킵변이에 대하여, 기능적인 인간 WRN 단백질을 발현하는 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염으로서,
    상기 올리고뉴클레오티드는, 각각의 뉴클레오티드가 인산기 및/또는 수식(修飾) 인산기로 결합되어 있고,
    상기 올리고뉴클레오티드는, 적어도 1개의 수식 당을 가지는 수식 핵산을 포함하고,
    상기 올리고뉴클레오티드의 염기길이는, 10∼30mer이며,
    상기 올리고뉴클레오티드의 염기서열은,
    서열번호 1, 서열번호 2, 서열번호 3, 서열번호 4, 서열번호 5, 또는 서열번호 6에 기재된 염기서열에서의, 상기 올리고뉴클레오티드와 동일한 염기길이로 구성된 적어도 1개의 표적 영역에 대하여 상보적인 염기서열을 기준으로 하여, 90% 이상 100% 이하의 서열동일성을 가지는 염기서열,
    상기 표적 영역에 있어서 1개 또는 수개의 염기가 결실, 치환, 삽입 또는 부가된 염기서열에 대하여, 상보적인 염기서열, 또는,
    상기 표적 영역을 가지는 올리고뉴클레오티드에 대하여, 스트린젠트한 조건에서 하이브리다이징하는 염기서열인,
    올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염.
  2. 제1항에 있어서,
    상기 올리고뉴클레오티드의 염기서열은,
    서열번호 1, 서열번호 2, 서열번호 3, 서열번호 4, 서열번호 5, 또는 서열번호 6에 기재된 염기서열에서의, 상기 올리고뉴클레오티드와 동일한 염기길이로 구성된 적어도 1개의 표적 영역에 대하여 상보적인 염기서열을 기준으로 하여, 95% 이상 100% 이하의 서열동일성을 가지는 염기서열인, 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염.
  3. 제1항에 있어서,
    상기 올리고뉴클레오티드의 염기서열은,
    서열번호 1, 서열번호 2, 서열번호 3, 서열번호 4, 서열번호 5, 또는 서열번호 6에 기재된 염기서열에서의, 상기 올리고뉴클레오티드와 동일한 염기길이로 구성된 적어도 1개의 표적 영역에 대하여 상보적인 염기서열인, 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염.
  4. 제1항 내지 제3항 중 어느 한 항에 있어서,
    상기 올리고뉴클레오티드의 염기길이는, 15∼25mer인, 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염.
  5. 제1항 내지 제4항 중 어느 한 항에 있어서,
    상기 올리고뉴클레오티드를 구성하는 당이 D-리보퓨라노스이며, 당의 수식이 상기 D-리보퓨라노스의 2'위치의 수산기의 당수식인, 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염.
  6. 제1항 내지 제5항 중 어느 한 항에 있어서,
    상기 올리고뉴클레오티드를 구성하는 당의 수식이 하기 식(A1)으로 표시되는 기인, 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염:

    (식 중, Bx는 핵산염기이며, 각각, 독립적으로, 아데닌, 구아닌, 시토신, 5-메틸시토신, 티민 또는 우라실로 표시되는 기이며, X는 인산 결합이며, 각각, 독립적으로, 포스포디에스테르 결합, 포스포로티오에이트 결합, 포스포로디티오에이트 결합, 포스포아미데이트 결합, 보라노포스페이트 결합 또는 알킬포스포네이트 결합이며, Y는, 각각, 독립적으로, 수소 원자, 수산기, 불소 원자, 치환되어 있어도 되는 탄소수 1∼6의 알콕시기, 또는 치환되어 있어도 되는 아미노기이며, Z는, 각각, 독립적으로, 수소 원자이거나, 탄소-산소 이중결합 또는 환상(環狀) 구조를 가지고 있어도 되는 탄소수 1∼5의 알킬기이거나, 또는 상기 알킬기의 일부 탄소 원자와 Y가 합쳐져서 환을 형성함).
  7. 제1항 내지 제6항 중 어느 한 항에 있어서,
    상기 올리고뉴클레오티드를 구성하는 당의 수식이 하기 식(A2) 또는 식(A3)으로 표시되는 기인, 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염:

    (식 중, Bx는 핵산염기이며, 각각, 독립적으로, 아데닌, 구아닌, 시토신, 5-메틸시토신, 티민 또는 우라실로 표시되는 기이며, X는 인산 결합이며, 각각, 독립적으로, 포스포디에스테르 결합, 포스포로티오에이트 결합, 포스포로디티오에이트 결합, 포스포아미데이트 결합, 보라노포스페이트 결합 또는 알킬포스포네이트 결합이며, R4는, 각각, 독립적으로, 수소 원자, 치환되어 있어도 되는 탄소수 1∼6의 알킬기이며, Y'는, 산소 원자 또는 치환되어 있어도 되는 질소 원자이며, R5 및 R6는, 각각, 독립적으로, 수소 원자, 치환되어 있어도 되는 탄소수 1∼6의 알킬기, 또는 R5 및 R6가 합쳐져서 카르보닐기 또는 환을 형성하고 있고, n은, 0 또는 1임).
  8. 제7항에 있어서,
    상기 올리고뉴클레오티드를 구성하는 당의 수식이 상기 식(A2)으로 표시되는 기이며, 상기 R4는, 각각, 독립적으로, 메틸기, 메톡시에틸기, 또는 N-메틸프로판아미드기인, 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염.
  9. 제7항에 있어서,
    상기 올리고뉴클레오티드를 구성하는 당의 수식이 상기 식(A3)으로 표시되는 기이며, 상기 Y'는, 산소 원자, 또는 수소 원자, 메틸기, 메톡시에틸기, 혹은 N-메틸프로판아미드기로 치환되어 있어도 되는 질소 원자이며, 상기 R5 및 R6는, 각각, 독립적으로, 수소 원자, 탄소수 1∼2의 알킬기, 또는 상기 R5 및 R6가 합쳐져서 카르보닐기 또는 탄소수 3∼6의 환을 형성하고 있고, n은, 0 또는 1인, 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염.
  10. 제1항 내지 제9항 중 어느 한 항에 있어서,
    상기 올리고뉴클레오티드 중 적어도 1개의 뉴클레오티드간 결합이 포스포로티오에이트 결합인, 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염.
  11. 제1항 내지 제10항 중 어느 한 항에 있어서,
    상기 올리고뉴클레오티드 중 적어도 1개의 뉴클레오티드간 결합이 포스포디에스테르 결합인, 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염.
  12. 제1항 내지 제9항 중 어느 한 항에 있어서,
    상기 올리고뉴클레오티드의 뉴클레오티드간 결합이 포스포디에스테르 결합 또는 포스포로티오에이트 결합인, 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염.
  13. 제1항 내지 제4항 중 어느 한 항에 있어서,
    상기 올리고뉴클레오티드의 염기서열은,
    상기 올리고뉴클레오티드가 하기 식(A4)으로 표시되는 모르폴리노핵산으로 구성되며, 서열번호 1, 서열번호 2, 서열번호 3, 서열번호 4, 서열번호 5, 또는 서열번호 6에 기재된 염기서열에서의, 상기 올리고뉴클레오티드와 동일한 염기길이로 구성된 적어도 1개의 표적 영역에 대하여 상보적인 염기서열을 가지는 모르폴리노올리고핵산인, 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염:

    (식 중, Bx는 핵산염기이며, 각각, 독립적으로, 아데닌, 구아닌, 시토신, 5-메틸시토신, 티민 또는 우라실로 표시되는 기이며, X'는 인산 결합이며, 각각, 독립적으로, 포스포로디아미데이트 결합, 포스포로디아미드티오에이트 결합, 또는 포스포로디아미드디티오에이트 결합임).
  14. 제1항 내지 제13항 중 어느 한 항에 있어서,
    상기 올리고뉴클레오티드의 염기서열은,
    서열번호 1에 기재된 염기서열에 있어서, 5'말단으로부터 카운트하여 1번∼40번, 46번, 51번, 56번, 혹은 62번∼63번에 위치하는 염기로부터 연속된 15∼25mer로 구성된 표적 영역, 또는 서열번호 2에 기재된 염기서열에 있어서, 5'말단으로부터 카운트하여 108873번, 108878번∼108917번, 108923번, 108928번, 108933번, 혹은 108939번∼108940번에 위치하는 염기로부터 연속된 15∼25mer로 구성된 표적 영역에 대하여 상보적인 염기서열을 기준으로 하여, 90% 이상 100% 이하의 서열동일성을 가지는 염기서열,
    상기 표적 영역에 있어서, 1개 또는 수개의 염기가 결실, 치환, 삽입 또는 부가 된 염기서열에 대하여 상보적인 염기서열, 또는,
    상기 표적 영역을 가지는 올리고뉴클레오티드에 대하여, 스트린젠트한 조건에서 하이브리다이징하는 염기서열인, 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염.
  15. 제1항 내지 제14항 중 어느 한 항에 있어서,
    상기 올리고뉴클레오티드의 염기서열은, 서열번호 1에 기재된 염기서열에 있어서, 5'말단으로부터 카운트하여 1번∼32번, 34번∼40번, 46번, 51번, 혹은 62번∼63번에 위치하는 염기로부터 연속된 15∼25mer로 구성된 표적 영역, 또는 서열번호 2에 기재된 염기서열에 있어서, 5'말단으로부터 카운트하여 108878번∼108909번, 108911번∼108917번, 108923번, 108928번, 혹은 108939번∼108940번에 위치하는 염기로부터 연속된 15∼25mer로 구성된 표적 영역에 대하여 상보적인 염기서열을 기준으로 하여, 90% 이상 100% 이하의 서열동일성을 가지는 염기서열인, 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염.
  16. 제1항 내지 제15항 중 어느 한 항에 있어서,
    상기 올리고뉴클레오티드의 염기서열은, 서열번호 1에 기재된 염기서열에 있어서, 5'말단으로부터 카운트하여 1번, 3번, 5번∼12번, 14번∼19번, 21번, 25번, 29번, 30번, 31번, 34번, 46번, 혹은 51번에 위치하는 염기로부터 연속된 15∼25mer로 구성된 표적 영역, 또는 서열번호 2에 기재된 염기서열에 있어서, 5'말단으로부터 카운트하여 108878번, 108880번, 108882번∼108889번, 108891번∼108896번, 108898번, 108902번, 108906번∼108908번, 108911번, 108923번, 혹은 108928번에 위치하는 염기로부터 연속된 15∼25mer로 구성된 표적 영역에 대하여 상보적인 염기서열을 기준으로 하여, 90% 이상 100% 이하의 서열동일성을 가지는 염기서열인, 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염.
  17. 제1항 내지 제16항 중 어느 한 항에 있어서,
    상기 올리고뉴클레오티드의 염기서열은, 서열번호 9∼14, 16∼26, 28∼39, 41∼42, 44∼50, 52, 55∼56, 69, 73, 80∼105, 107∼108, 110, 112, 114, 116, 118∼131, 133, 및 135의 염기서열로 이루어지는 군으로부터 선택되는 1개의 염기서열인, 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염.
  18. 제1항 내지 제17항 중 어느 한 항에 있어서,
    상기 올리고뉴클레오티드는, 표 2-1∼표 2-7에 기재된 서열명 6-20-A, 8-20-A, 8-20-B, 8-20-C, 9-20-A, 10-20-A, 12-20-A, 14-20-A, 16-20-A, 17-20-A, 18-20-A, 19-20-A, 15-25-A, 10-17-A, 10-20-B, 12-20-B, 14-20-B, 15-20-B, 16-20-B, 19-20-B, 31-20-B, 34-20-B, 6-20-B, 7-20-B, 8-20-D, 및 9-20-B로 이루어지는 군으로부터 선택되는 1개의 올리고뉴클레오티드인, 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염.
  19. 제1항 내지 제18항 중 어느 한 항에 있어서,
    상기 올리고뉴클레오티드는, 단일가닥 안티센스 올리고뉴클레오티드인, 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염.
  20. 제19항에 기재된 올리고뉴클레오티드와,
    상기 단일가닥 안티센스 올리고뉴클레오티드에 대하여 하이브리다이징하고 있는 제2쇄 올리고뉴클레오티드를 포함하는 이중가닥 안티센스 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염으로서,
    상기 제2쇄 올리고뉴클레오티드의 염기서열은, 상기 단일가닥 안티센스 올리고뉴클레오티드의 염기서열에 대하여 상보적인 염기서열을 기준으로 하여, 90% 이상 100% 이하의 서열동일성을 가지는 염기서열인, 이중가닥 안티센스 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염.
  21. 제1항 내지 제19항 중 어느 한 항에 기재된 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 또는 제20항에 기재된 이중가닥 안티센스 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염과,
    상기 올리고뉴클레오티드 또는 상기 제2쇄 올리고뉴클레오티드에, 직접 또는 링커 결합을 통하여 결합되어 있는 부가물질을 가지는, 올리고뉴클레오티드 복합체 또는 그의 제약학적으로 허용되는 염으로서,
    상기 부가물질은, 폴리에틸렌글리콜, 펩티드, 알킬쇄, 리간드 화합물, 항체, 단백질 및 당쇄로 이루어지는 군으로부터 선택되고,
    상기 링커 결합은, 각각, 독립적으로 포스포디에스테르 결합, 포스포로티오에이트 결합, 포스포로디티오에이트 결합, 포스포아미데이트 결합, 보라노포스페이트 결합, 알킬포스포네이트 결합, 포스포로디아미데이트 결합, 포스포로디아미드티오에이트 결합, 또는 포스포로디아미드디티오에이트 결합인, 올리고뉴클레오티드 복합체 또는 그의 제약학적으로 허용되는 염.
  22. 제1항 내지 제19항 중 어느 한 항에 기재된 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 제20항에 기재된 이중가닥 안티센스 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 또는 제21항에 기재된 올리고뉴클레오티드 복합체 또는 그의 제약학적으로 허용되는 염을 유효성분으로서 포함하는, 의약품.
  23. 제1항 내지 제19항 중 어느 한 항에 기재된 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 제20항에 기재된 이중가닥 안티센스 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 또는 제21항에 기재된 올리고뉴클레오티드 복합체 또는 그의 제약학적으로 허용되는 염을 유효성분으로서 포함하는, 인간 WRN 유전자의 제27번째 엑손의 스킵핑제.
  24. 제1항 내지 제19항 중 어느 한 항에 기재된 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 제20항에 기재된 이중가닥 안티센스 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 또는 제21항에 기재된 올리고뉴클레오티드 복합체 또는 그의 제약학적으로 허용되는 염을 유효성분으로서 포함하는, 인간 WRN 유전자의 제27번째의 엑손의 스킵핑에 의한 핵이행신호를 보유하는 기능적 WRN 회복제.
  25. 제1항 내지 제19항 중 어느 한 항에 기재된 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 제20항에 기재된 이중가닥 안티센스 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 또는 제21항에 기재된 올리고뉴클레오티드 복합체 또는 그의 제약학적으로 허용되는 염을 유효성분으로서 포함하는, 베르너 증후군에 대한 치료제.
  26. 제1항 내지 제19항 중 어느 한 항에 기재된 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 제20항에 기재된 이중가닥 안티센스 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 또는 제21항에 기재된 올리고뉴클레오티드 복합체 또는 그의 제약학적으로 허용되는 염을 유효성분으로서 포함하는, 베르너 증후군에 대한 예방제.
  27. 제1항 내지 제19항 중 어느 한 항에 기재된 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 제20항에 기재된 이중가닥 안티센스 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 또는 제21항에 기재된 올리고뉴클레오티드 복합체 또는 그의 제약학적으로 허용되는 염을 개체에 투여하는 공정을 포함하는, 베르너 증후군의 치료 방법 또는 예방 방법.
  28. 베르너 증후군의 치료 또는 예방에 사용하기 위한, 제1항 내지 제19항 중 어느 한 항에 기재된 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 제20항에 기재된 이중가닥 안티센스 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 또는 제21항에 기재된 올리고뉴클레오티드 복합체 또는 그의 제약학적으로 허용되는 염.
  29. 베르너 증후군의 치료제 또는 예방제를 제조하기 위해 사용하는, 제1항 내지 제19항 중 어느 한 항에 기재된 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 제20항에 기재된 이중가닥 안티센스 올리고뉴클레오티드 또는 그의 제약학적으로 허용되는 염, 또는 제21항에 기재된 올리고뉴클레오티드 복합체 또는 그의 제약학적으로 허용되는 염.
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