DE69033986T2 - Ungeladene, auf Morpholin basierende Polymere mit Chiralen, Phosphor enthaltenden Brücken zwischen den Untereinheiten - Google Patents

Ungeladene, auf Morpholin basierende Polymere mit Chiralen, Phosphor enthaltenden Brücken zwischen den Untereinheiten

Info

Publication number
DE69033986T2
DE69033986T2 DE69033986T DE69033986T DE69033986T2 DE 69033986 T2 DE69033986 T2 DE 69033986T2 DE 69033986 T DE69033986 T DE 69033986T DE 69033986 T DE69033986 T DE 69033986T DE 69033986 T2 DE69033986 T2 DE 69033986T2
Authority
DE
Germany
Prior art keywords
uncharged
phosphorus
subunit
chiral
subunits
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69033986T
Other languages
English (en)
Other versions
DE69033986D1 (de
Inventor
James E Summerton
Dwight D Weller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sarepta Therapeutics Inc
Original Assignee
Antivirals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Antivirals Inc filed Critical Antivirals Inc
Publication of DE69033986D1 publication Critical patent/DE69033986D1/de
Application granted granted Critical
Publication of DE69033986T2 publication Critical patent/DE69033986T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G79/00—Macromolecular compounds obtained by reactions forming a linkage containing atoms other than silicon, sulfur, nitrogen, oxygen, and carbon with or without the latter elements in the main chain of the macromolecule
    • C08G79/02—Macromolecular compounds obtained by reactions forming a linkage containing atoms other than silicon, sulfur, nitrogen, oxygen, and carbon with or without the latter elements in the main chain of the macromolecule a linkage containing phosphorus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Peptides Or Proteins (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Polyamides (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69033986T 1989-12-20 1990-12-20 Ungeladene, auf Morpholin basierende Polymere mit Chiralen, Phosphor enthaltenden Brücken zwischen den Untereinheiten Expired - Lifetime DE69033986T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45405789A 1989-12-20 1989-12-20

Publications (2)

Publication Number Publication Date
DE69033986D1 DE69033986D1 (de) 2002-08-14
DE69033986T2 true DE69033986T2 (de) 2003-03-13

Family

ID=23803120

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69034213T Expired - Lifetime DE69034213T2 (de) 1989-12-20 1990-12-20 Ungeladene, auf morpholin basierende polymere mit chiralen, phosphor enthaltenden brücken zwischen den untereinheiten
DE69033986T Expired - Lifetime DE69033986T2 (de) 1989-12-20 1990-12-20 Ungeladene, auf Morpholin basierende Polymere mit Chiralen, Phosphor enthaltenden Brücken zwischen den Untereinheiten

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69034213T Expired - Lifetime DE69034213T2 (de) 1989-12-20 1990-12-20 Ungeladene, auf morpholin basierende polymere mit chiralen, phosphor enthaltenden brücken zwischen den untereinheiten

Country Status (8)

Country Link
EP (2) EP0506830B1 (de)
JP (2) JP3398378B2 (de)
KR (1) KR0167574B1 (de)
AT (2) ATE312834T1 (de)
AU (1) AU655164B2 (de)
CA (1) CA2069869C (de)
DE (2) DE69034213T2 (de)
WO (1) WO1991009033A1 (de)

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US5405938A (en) * 1989-12-20 1995-04-11 Anti-Gene Development Group Sequence-specific binding polymers for duplex nucleic acids
US5166315A (en) * 1989-12-20 1992-11-24 Anti-Gene Development Group Sequence-specific binding polymers for duplex nucleic acids
WO1998046740A1 (en) * 1997-04-17 1998-10-22 Antivirals, Inc. Method of treating restenosis by antisense targeting of cmv
US20010024783A1 (en) * 1999-01-29 2001-09-27 Avi Biopharma, Inc. Non-invasive method for detecting target RNA
KR20010102992A (ko) * 1999-01-29 2001-11-17 추후보정 표적 ｒｎａ를 검출하는 비-침입적 방법
AU781094B2 (en) * 1999-05-24 2005-05-05 Avi Biopharma, Inc. Antisense to c-myc for treatment of polycystic kidney disease
US6875747B1 (en) 1999-05-24 2005-04-05 Avi Bio Pharma, Inc. Antisense to c-myc for treatment of polycystic kidney disease
US6677153B2 (en) 1999-11-29 2004-01-13 Avi Biopharma, Inc. Antisense antibacterial method and composition
JP2003518946A (ja) * 2000-01-04 2003-06-17 エイブイアイ バイオファーマ， インコーポレイテッド アンチセンス抗細菌性細胞分裂組成物、およびその方法
ATE510914T1 (de) 2004-07-02 2011-06-15 Avi Biopharma Inc Antisinn antibakterielle verfahren und verbindungen
US8067571B2 (en) 2005-07-13 2011-11-29 Avi Biopharma, Inc. Antibacterial antisense oligonucleotide and method
LT2024499T (lt) * 2006-05-10 2018-02-26 Sarepta Therapeutics, Inc. Oligonukleotido analogai, turintys katijonines jungtis tarp subvienetų
MX2010004955A (es) * 2007-11-15 2010-06-30 Avi Biopharma Inc Metodo de sintesis de oligomeros de morfolina.
KR101981705B1 (ko) * 2010-05-28 2019-05-24 사렙타 쎄러퓨틱스, 인코퍼레이티드 변형된 서브유니트간 결합 및/또는 말단 그룹을 갖는 올리고뉴클레오타이드 유사체
AU2013202731B2 (en) * 2010-05-28 2016-04-21 Sarepta Therapeutics, Inc. Oligonucleotide analogues having modified intersubunit linkages and/or terminal groups
TWI541024B (zh) 2010-09-01 2016-07-11 日本新藥股份有限公司 反義核酸
WO2012031243A2 (en) 2010-09-03 2012-03-08 Avi Biopharma, Inc. dsRNA MOLECULES COMPRISING OLIGONUCLEOTIDE ANALOGS HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS
EP2623507B1 (de) 2010-09-30 2016-11-02 Nippon Shinyaku Co., Ltd. Morpholin-nukleinsäurederivat
EA202090338A1 (ru) 2011-11-18 2021-04-30 Сарепта Терапьютикс, Инк. Функционально-модифицированные олигонуклеотиды и их субъединицы
CN117721110A (zh) 2011-12-28 2024-03-19 日本新药株式会社 反义核酸
WO2013142087A1 (en) 2012-03-20 2013-09-26 Sarepta Therapeutics, Inc. Boronic acid conjugates of oligonucleotide analogues
EP3015467A4 (de) 2013-05-24 2016-11-02 Ajinomoto Kk Morpholin-oligonukleotid-herstellungsverfahren
SG11201607095RA (en) 2014-03-12 2016-10-28 Nippon Shinyaku Co Ltd Antisense nucleic acids
LT3159409T (lt) 2014-06-17 2020-01-27 Nippon Shinyaku Co., Ltd. Antiprasminė nukleorūgštis, skirta panaudoti diušeno raumenų distrofijos gydymui
JP6673211B2 (ja) * 2014-10-14 2020-03-25 味の素株式会社 モルフォリノオリゴヌクレオチドの製造方法
CN107207555B (zh) 2015-01-21 2021-10-22 味之素株式会社 沉淀促进剂以及使用其的沉淀方法
EP3302489A4 (de) 2015-06-04 2019-02-06 Sarepta Therapeutics, Inc. Verfahren und verbindungen zur behandlung von krankheiten und leiden im zusammenhang mit lymphozyten
CN108026531B (zh) 2015-09-15 2021-09-14 日本新药株式会社 反义核酸
WO2017047741A1 (ja) 2015-09-16 2017-03-23 日本新薬株式会社 筋萎縮症治療用アンチセンス核酸
AU2017330276B2 (en) * 2016-09-20 2022-01-20 The Regents Of The University Of Colorado, A Body Corporate Synthesis of backbone modified morpholino oligonucleotides and chimeras using phosphoramidite chemistry
US11560401B2 (en) 2018-05-10 2023-01-24 Nippon Shinyaku Co., Ltd. Method for preparing oligonucleic acid compound
KR20210023988A (ko) 2018-06-26 2021-03-04 니뽄 신야쿠 가부시키가이샤 안티센스 올리고뉴클레오티드를 함유하는 조성물 및 듀시엔형 근이영양증의 치료로의 그의 사용
GB201821269D0 (en) 2018-12-28 2019-02-13 Nippon Shinyaku Co Ltd Myostatin signal inhibitor
US20230014840A1 (en) 2019-11-13 2023-01-19 Nippon Shinyaku Co., Ltd. Method for producing oligonucleic acid compound
US20230018780A1 (en) 2019-11-13 2023-01-19 Nippon Shinyaku Co., Ltd. Method for producing oligonucleic acid compound
US20230045557A1 (en) 2019-12-19 2023-02-09 Nippon Shinyaku Co., Ltd. Antisense nucleic acid enabling exon skipping
IL294271A (en) 2019-12-26 2022-08-01 Nippon Shinyaku Co Ltd Antisense nucleic acids that cause splicing on exon 50
EP4112083A1 (de) 2020-02-28 2023-01-04 Nippon Shinyaku Co., Ltd. Antisense-nukleinsäure, die das überspringen von exon51 induziert
WO2022214692A1 (en) 2021-04-09 2022-10-13 Bachem Holding Ag Pseudo solid phase protecting group and methods for the synthesis of oligonucleotides and oligonucleotide conjugates
CA3218264A1 (en) 2021-04-28 2022-11-03 Nippon Shinyaku Co., Ltd. Method for producing oligonucleic acid compound
EP4342498A1 (de) 2021-05-13 2024-03-27 National University Corporation Chiba University Antisense-oligomer
WO2022250155A1 (ja) 2021-05-28 2022-12-01 住友ファーマ株式会社 アンチセンス核酸
BR112023027298A2 (pt) 2021-06-23 2024-03-12 Nat Center Neurology & Psychiatry Combinação de oligômeros antissenso
JPWO2023282346A1 (de) 2021-07-08 2023-01-12
EP4368176A1 (de) 2021-07-08 2024-05-15 Nippon Shinyaku Co., Ltd. Mittel zur reduzierung der nephrotoxizität
IL310003A (en) 2021-07-08 2024-03-01 Nippon Shinyaku Co Ltd A substance that lowers nephrotoxicity
JPWO2023026994A1 (de) 2021-08-21 2023-03-02

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5698186A (en) * 1985-03-15 1986-10-13 Summerton, J. Polynucleotide assay reagent and method

Also Published As

Publication number Publication date
EP0962463B1 (de) 2002-07-10
JP3398378B2 (ja) 2003-04-21
EP0506830B1 (de) 2005-12-14
KR0167574B1 (ko) 1999-01-15
AU7164291A (en) 1991-07-18
JP2002167441A (ja) 2002-06-11
DE69034213D1 (de) 2006-01-19
AU655164B2 (en) 1994-12-08
ATE312834T1 (de) 2005-12-15
KR920703584A (ko) 1992-12-18
ATE220407T1 (de) 2002-07-15
CA2069869A1 (en) 1991-06-21
EP0506830A1 (de) 1992-10-07
JPH05504563A (ja) 1993-07-15
DE69034213T2 (de) 2006-08-24
EP0962463A1 (de) 1999-12-08
DE69033986D1 (de) 2002-08-14
WO1991009033A1 (en) 1991-06-27
EP0506830A4 (en) 1993-01-07
CA2069869C (en) 1995-12-19

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