ES2032861T3 - Procedimiento para preparar un medicamento a base de 5-hetero- o aril-substituido-imidazo (2,1-a)isoquinolina. - Google Patents
Procedimiento para preparar un medicamento a base de 5-hetero- o aril-substituido-imidazo (2,1-a)isoquinolina.Info
- Publication number
- ES2032861T3 ES2032861T3 ES198787810387T ES87810387T ES2032861T3 ES 2032861 T3 ES2032861 T3 ES 2032861T3 ES 198787810387 T ES198787810387 T ES 198787810387T ES 87810387 T ES87810387 T ES 87810387T ES 2032861 T3 ES2032861 T3 ES 2032861T3
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- imidazo
- isoquinoline
- hetero
- medication
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- -1 monochlorophenyl Chemical group 0.000 abstract 3
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001153 fluoro group Chemical group F* 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 206010015866 Extravasation Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000036251 extravasation Effects 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
- C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
COMPUESTOS DE FORMULA (I) EN DONDE CADA R ES INDEPENDIENTEMENTE HIDROGENO O METIL; R1 ESTA EN POSICION 8- O 9- Y REPRESENTA HIDROGENO, CLORO, FLUOR O ALQUILO C1-5 Y R2 REPRESENTA TIENIL, FURIL O (II) EN DONDE CADA R0 REPRESENTA INDEPENDIENTEMENTE HIDROGENO, FLUOR, CLORO, ALQUILO C1-10, ALCOXI C1-10 O ALQUILTIO C1-10 O UN R0 ES HIDROGENO Y EL OTRO REPRESENTA TRI-(ALQUILO C1-3 SILIL, TRIFLUOROMETIL, FENIL MONOCLOROFENIL, MONOFLUOROFENIL (III) EN DONDE X, Y, R3, R3'' O R4 SON COMO DEFINIDOS DEL MISMO O DOS R0 SOBRE EL METILENDIOXI QUE FORMA ATOMOS DE CARBONO ADYACENTES. LOS COMPUESTOS ESTAN INDICADOS PARA SU USO EN EL TRATAMIENTO DE LA BRONCOCONTRICCION MEDIATIZADA POR PAF Y DE LA EXTRAVASACION.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88511586A | 1986-07-14 | 1986-07-14 | |
| US1351587A | 1987-02-11 | 1987-02-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2032861T3 true ES2032861T3 (es) | 1993-03-01 |
Family
ID=26684931
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES198787810387T Expired - Lifetime ES2032861T3 (es) | 1986-07-14 | 1987-07-07 | Procedimiento para preparar un medicamento a base de 5-hetero- o aril-substituido-imidazo (2,1-a)isoquinolina. |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0258175B1 (es) |
| JP (1) | JPH01500270A (es) |
| KR (1) | KR960003609B1 (es) |
| AT (1) | ATE74357T1 (es) |
| AU (1) | AU604739B2 (es) |
| CA (1) | CA1317942C (es) |
| CY (1) | CY1828A (es) |
| DE (1) | DE3777919D1 (es) |
| DK (1) | DK170213B1 (es) |
| ES (1) | ES2032861T3 (es) |
| FI (1) | FI88159C (es) |
| GR (1) | GR3004258T3 (es) |
| HK (1) | HK71295A (es) |
| HU (1) | HU206114B (es) |
| IE (1) | IE60277B1 (es) |
| IL (1) | IL83164A (es) |
| MY (1) | MY101895A (es) |
| NZ (1) | NZ221054A (es) |
| PH (1) | PH24430A (es) |
| PL (1) | PL154159B1 (es) |
| SG (1) | SG8595G (es) |
| WO (1) | WO1988000587A2 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4910206A (en) * | 1986-07-14 | 1990-03-20 | Sandoz Pharmaceuticals Corp. | 5-hetero-or aryl-substituted-imidazo(2,1-a)isoquinolines and their use as PAF receptor antagonists |
| EP0338993A1 (en) * | 1988-04-21 | 1989-10-25 | Sandoz Ag | 6-Aryl-substituted-4h-thieno[2,3-e][1,2,4]triazolo [3,4-c][1,4]diazepines |
| ATE118777T1 (de) * | 1988-05-05 | 1995-03-15 | Sandoz Ag | 5-aryl-substituierte-2,3-dihydro-imidazo(1,2- a>furo(3,2-c>- oder thieno(2,3-c>pyridine. |
| US5939090A (en) | 1996-12-03 | 1999-08-17 | 3M Innovative Properties Company | Gel formulations for topical drug delivery |
| CN1076728C (zh) * | 1999-02-05 | 2001-12-26 | 浙江大学 | 2－芳基咪唑并[2,1－a]异喹啉的衍生物及其用途 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1347493A (en) * | 1971-02-11 | 1974-02-27 | Aspro Nicholas Ltd | Benzazine derivatives |
-
1987
- 1987-07-07 EP EP87810387A patent/EP0258175B1/en not_active Expired - Lifetime
- 1987-07-07 JP JP62504237A patent/JPH01500270A/ja active Granted
- 1987-07-07 AT AT87810387T patent/ATE74357T1/de not_active IP Right Cessation
- 1987-07-07 HU HU873833A patent/HU206114B/hu not_active IP Right Cessation
- 1987-07-07 ES ES198787810387T patent/ES2032861T3/es not_active Expired - Lifetime
- 1987-07-07 WO PCT/EP1987/000366 patent/WO1988000587A2/en active IP Right Grant
- 1987-07-07 DE DE8787810387T patent/DE3777919D1/de not_active Expired - Lifetime
- 1987-07-07 AU AU76941/87A patent/AU604739B2/en not_active Ceased
- 1987-07-11 MY MYPI87000989A patent/MY101895A/en unknown
- 1987-07-13 IE IE187687A patent/IE60277B1/en not_active IP Right Cessation
- 1987-07-13 CA CA000542087A patent/CA1317942C/en not_active Expired - Fee Related
- 1987-07-13 IL IL83164A patent/IL83164A/xx unknown
- 1987-07-13 NZ NZ221054A patent/NZ221054A/xx unknown
- 1987-07-13 PL PL1987266801A patent/PL154159B1/pl unknown
- 1987-07-14 PH PH35535A patent/PH24430A/en unknown
-
1988
- 1988-03-11 KR KR88700272A patent/KR960003609B1/ko not_active IP Right Cessation
- 1988-03-11 FI FI881165A patent/FI88159C/fi not_active IP Right Cessation
- 1988-03-14 DK DK138388A patent/DK170213B1/da not_active IP Right Cessation
-
1992
- 1992-04-02 GR GR920400538T patent/GR3004258T3/el unknown
-
1995
- 1995-01-18 SG SG8595A patent/SG8595G/en unknown
- 1995-05-11 HK HK71295A patent/HK71295A/xx not_active IP Right Cessation
- 1995-12-01 CY CY182895A patent/CY1828A/xx unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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