CA2055093A1 - Mono-n-substituted 1,4,7,10-tetraazacyclododecane derivatives, process for their production and pharmaceutical agents containing these derivatives - Google Patents
Mono-n-substituted 1,4,7,10-tetraazacyclododecane derivatives, process for their production and pharmaceutical agents containing these derivativesInfo
- Publication number
- CA2055093A1 CA2055093A1 CA002055093A CA2055093A CA2055093A1 CA 2055093 A1 CA2055093 A1 CA 2055093A1 CA 002055093 A CA002055093 A CA 002055093A CA 2055093 A CA2055093 A CA 2055093A CA 2055093 A1 CA2055093 A1 CA 2055093A1
- Authority
- CA
- Canada
- Prior art keywords
- groups
- optionally
- hydroxy
- radicals
- meaning
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEP4035760.0 | 1990-11-08 | ||
DE4035760A DE4035760A1 (de) | 1990-11-08 | 1990-11-08 | Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2055093A1 true CA2055093A1 (en) | 1992-05-09 |
Family
ID=6417983
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002055093A Abandoned CA2055093A1 (en) | 1990-11-08 | 1991-11-07 | Mono-n-substituted 1,4,7,10-tetraazacyclododecane derivatives, process for their production and pharmaceutical agents containing these derivatives |
Country Status (16)
Country | Link |
---|---|
US (2) | US5277895A (no) |
EP (1) | EP0485045B1 (no) |
JP (1) | JP3137700B2 (no) |
AT (1) | ATE175201T1 (no) |
AU (1) | AU8772691A (no) |
CA (1) | CA2055093A1 (no) |
DE (2) | DE4035760A1 (no) |
DK (1) | DK0485045T3 (no) |
ES (1) | ES2128307T3 (no) |
FI (1) | FI915282A (no) |
GR (1) | GR3029775T3 (no) |
IE (1) | IE913899A1 (no) |
IL (1) | IL100015A0 (no) |
NO (1) | NO914356L (no) |
PT (1) | PT99445B (no) |
ZA (1) | ZA918893B (no) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008134289A2 (en) * | 2007-04-26 | 2008-11-06 | Mallinckrodt Inc. | High relaxivity coordinatively unsaturated lanthanide complexes |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5362476A (en) * | 1984-10-18 | 1994-11-08 | Board Of Regents, The University Of Texas System | Alkyl phosphonate polyazamacrocyclic cheates for MRI |
US5316757A (en) * | 1984-10-18 | 1994-05-31 | Board Of Regents, The University Of Texas System | Synthesis of polyazamacrocycles with more than one type of side-chain chelating groups |
GB9320277D0 (en) * | 1993-10-01 | 1993-11-17 | Nycomed Salutar Inc | Chelants |
US5650133A (en) * | 1990-01-19 | 1997-07-22 | Nycomed Salutar | Macrocyclic polyaza dichelates linked through ring nitrogens via an amide or ester functionality |
US5972307A (en) * | 1989-10-23 | 1999-10-26 | Nycomed Salutar, Inc. | Dichelants |
US5021409A (en) * | 1989-12-21 | 1991-06-04 | Johnson Matthey Plc | Antiviral cyclic polyamines |
DE4115789A1 (de) * | 1991-05-10 | 1992-11-12 | Schering Ag | Makrocyclische polymer-komplexbildner, deren komplexe, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
TW213864B (no) * | 1991-08-01 | 1993-10-01 | Squibb & Sons Inc | |
US5410043A (en) * | 1991-12-06 | 1995-04-25 | Schering Aktiengesellschaft | Process for the production of mono-N-substituted tetraaza macrocycles |
DE4140779A1 (de) * | 1991-12-06 | 1993-06-09 | Schering Ag Berlin Und Bergkamen, 1000 Berlin, De | Verfahren zur herstellung von mono-n-substituierten tetraazamakrocyclen |
DE4237943C2 (de) * | 1992-11-06 | 1997-10-23 | Schering Ag | Verfahren zur Herstellung von Metallkomplexen der N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecan- und N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivate |
DE4218744C2 (de) * | 1992-06-04 | 1997-11-06 | Schering Ag | Verfahren zur Herstellung von N-ß-Hxdroxyalkyl-tri-N-carboxylalkyl-1,4,7,10-tetraazacyclododecan- und N-ß-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivaten und deren Metallkomplexe |
EP0646019B9 (en) * | 1992-06-09 | 2002-12-18 | Neorx Corporation | Biotin-DOTA conjugates and their use in pretargeting methods |
DE4317588C2 (de) * | 1993-05-24 | 1998-04-16 | Schering Ag | Fluorhaltige makrocyclische Metallkomplexe, Verfahren zu ihrer Herstellung, sowie ihre Verwendung |
DE4318369C1 (de) * | 1993-05-28 | 1995-02-09 | Schering Ag | Verwendung von makrocyclischen Metallkomplexen als Temperatursonden |
GB9318550D0 (en) * | 1993-09-07 | 1993-10-20 | Nycomed Salutar Inc | Chelants |
ATE199550T1 (de) * | 1993-12-30 | 2001-03-15 | Guerbet Sa | Polyaminierte liganden, metallkomplexe, verfahren zur herstellung und diagnostische und therapeutische verwendungen |
GB9407435D0 (en) * | 1994-04-14 | 1994-06-08 | Nycomed Salutar Inc | Compounds |
US6693190B1 (en) * | 1994-05-11 | 2004-02-17 | Bracco International B.V. | Enhanced relaxivity monomeric and multimeric compounds |
IT1274038B (it) * | 1994-07-29 | 1997-07-14 | Bracco Spa | Chelanti macrociclici loro chelati e relativi usi in campo diagnostico |
TW319763B (no) | 1995-02-01 | 1997-11-11 | Epix Medical Inc | |
US5955605A (en) * | 1995-02-21 | 1999-09-21 | Neorx Corporation | Biotinidase resistant biotin-DOTA conjugates |
US5801228A (en) * | 1995-06-07 | 1998-09-01 | Nycomed Imaging As | Polymeric contrast agents for medical imaging |
DE19546234C1 (de) * | 1995-12-04 | 1997-08-28 | Schering Ag | Neue makrobicyclische Verbindungen, Verfahren zu ihrer Herstellung und diese makrobicyclischen Verbindungen enthaltende pharmazeutische Mittel |
US6045776A (en) * | 1996-12-04 | 2000-04-04 | Schering Aktiengesellschaft | Process for the production of metal-complex carboxylic acid amides |
US5919433A (en) * | 1996-12-04 | 1999-07-06 | Schering Aktiengesellschaft | Macrocyclic metal complex carboxylic acids, their use as well as process for their production |
DE19719033C1 (de) * | 1997-04-29 | 1999-01-28 | Schering Ag | Ionenpaare, Verfahren zu ihrer Herstellung und ihre Verwendung als Kontrastmittel |
DE19724186C2 (de) * | 1997-06-02 | 2002-07-18 | Schering Ag | Verfahren zur Mono- und 1,7-Bis-N-ß-Hydroxyalkylierung von Cyclen und die entsprechenden N-ß-Hydroxyalkyl-1,4,7,10-tetraazacyclododecan-Li-Salz-Komplexe |
IT1292128B1 (it) * | 1997-06-11 | 1999-01-25 | Bracco Spa | Processo per la preparazione di chelanti macrociclici e loro chelati con ioni metallici paramagnetici |
DE19744003B4 (de) * | 1997-09-26 | 2004-07-08 | Schering Ag | Kontrastmittel für das Infarkt- und Nekroseimaging |
US5991513A (en) * | 1997-09-30 | 1999-11-23 | Levien; Raphael L | Method and apparatus for suppressing moire patterns |
FR2772025B1 (fr) * | 1997-12-10 | 2000-03-03 | Guerbet Sa | Chelates metalliques de macrocycles polyaminocarboxyliques et leur application a l'imagerie par resonance magnetique |
DE19849465A1 (de) * | 1998-10-21 | 2000-04-27 | Schering Ag | Dimere Ionenpaare, Verfahren zu ihrer Herstellung und ihre Verwendung als Kontrastmittel |
US6342598B1 (en) | 1998-11-26 | 2002-01-29 | Bracco International B.V. | Amphipatic polycarboxylic chelates and complexes with paramagnetic metals as MRI contrast agents |
AU3225900A (en) * | 1999-02-09 | 2000-08-29 | Board Of Regents, The University Of Texas System | Ph sensitive mri contrast agents |
EP1088559A3 (de) * | 1999-09-29 | 2002-10-02 | INSTITUT FÜR DIAGNOSTIKFORSCHUNG GmbH AN DER FREIEN UNIVERSITÄT BERLIN | Galenische Formulierungen |
US20030113267A1 (en) * | 1999-12-29 | 2003-06-19 | Knopp Michael V. | Colon contrast enhanced imaging |
DE60136476D1 (de) | 2000-09-29 | 2008-12-18 | Anormed Inc | -stickstoffhaltigen zyklischen polyaminen und deren verbindungen |
US7048907B2 (en) * | 2001-02-05 | 2006-05-23 | Biophysics Assay Laboratory, Inc. | Synthesis, compositions and methods for the measurement of the concentration of stable-isotope labeled compounds in life forms and life form excretory products |
US6906050B2 (en) * | 2001-05-31 | 2005-06-14 | Miravant Pharmaceuticals, Inc. | Substituted porphyrin and azaporphyrin derivatives and their use in photodynamic therapy, radioimaging and MRI diagnosis |
US6911671B2 (en) * | 2002-09-23 | 2005-06-28 | Eastman Kodak Company | Device for depositing patterned layers in OLED displays |
US7067170B2 (en) * | 2002-09-23 | 2006-06-27 | Eastman Kodak Company | Depositing layers in OLED devices using viscous flow |
JP2006515630A (ja) * | 2003-01-22 | 2006-06-01 | ザ ジェネラル ホスピタル コーポレイション | アミロイド結合性金属キレート剤 |
US8074729B2 (en) | 2007-11-28 | 2011-12-13 | Cnh America Llc | Vertical tillage system |
EP2072060A1 (en) | 2007-12-18 | 2009-06-24 | Institut Curie | Methods and compositions for the preparation and use of toxin conjugates. |
US20120093725A1 (en) | 2009-04-10 | 2012-04-19 | Inserm (Institut National De La Sante Et De La Recherche Medicale | Fucoidans as Ligands for the Diagnosis of Degenerative Pathologies |
GB0922369D0 (en) * | 2009-12-22 | 2010-02-03 | Hammersmith Imanet Ltd | Labelled biotin conjugates |
CN103189057B (zh) * | 2010-08-26 | 2015-02-18 | 崔坤元 | 大环脂类化合物及其应用 |
WO2012136813A2 (en) | 2011-04-07 | 2012-10-11 | Universitetet I Oslo | Agents for medical radar diagnosis |
RS60001B1 (sr) | 2011-04-21 | 2020-04-30 | Bayer Ip Gmbh | Pripremanje gadobutrola visoke čistoće |
US20150337308A1 (en) | 2012-04-11 | 2015-11-26 | Chu De Bordeaux | Matrix metalloproteinase 9 (mmp-9) aptamer and uses thereof |
JP6178198B2 (ja) | 2013-09-30 | 2017-08-09 | 株式会社東芝 | 音声翻訳システム、方法およびプログラム |
WO2015117626A1 (de) * | 2014-02-07 | 2015-08-13 | Rijksuniversiteit Groningen | Oligo- und polyaminotetrazole und ihre verwendung als mri kontrastmittel |
ES2932302T3 (es) * | 2015-12-10 | 2023-01-17 | Bracco Imaging Spa | Agentes de contraste diméricos |
US10781188B2 (en) | 2015-12-10 | 2020-09-22 | Bracco Imaging S.P.A. | Contrast agents |
US11007283B2 (en) | 2016-04-13 | 2021-05-18 | Bracco Imaging S.P.A. | Contrast agents |
PL3519394T3 (pl) | 2016-09-27 | 2020-11-30 | Bayer Pharma Aktiengesellschaft | Sposób wytwarzania krystalicznej postaci o modyfikacji a kalkobutrolu |
ES2899033T3 (es) | 2016-12-12 | 2022-03-09 | Bracco Imaging Spa | Agentes de contraste diméricos |
CN110357828B (zh) * | 2019-08-13 | 2021-03-19 | 牡丹江医学院 | 一种核磁共振造影剂及其制备方法和用途 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS53144592A (en) * | 1977-05-19 | 1978-12-15 | Tabuse Iwao | 122alkyll1*4*7*100tetrazacyclotridecane |
JPS53144593A (en) * | 1977-05-19 | 1978-12-15 | Iwao Tabuse | Alklycyclum |
US4190462A (en) * | 1978-07-04 | 1980-02-26 | Shell Oil Company | Dissolving barium sulfate scale with aqueous solutions of salts of carboxymethyl monocyclic macrocyclic polyamines |
US4647447A (en) * | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
US5059412A (en) * | 1984-06-04 | 1991-10-22 | The Dow Chemical Company | Macrocyclic aminophosphonic acid complexes for the treatment of calcific tumors |
US4678667A (en) * | 1985-07-02 | 1987-07-07 | 501 Regents of the University of California | Macrocyclic bifunctional chelating agents |
EP0232751B1 (en) * | 1986-01-23 | 1991-09-11 | E.R. Squibb & Sons, Inc. | 1-substituted-4,7,10-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs |
US4885363A (en) * | 1987-04-24 | 1989-12-05 | E. R. Squibb & Sons, Inc. | 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs |
DE3625417C2 (de) * | 1986-07-28 | 1998-10-08 | Schering Ag | Tetraazacyclododecan-Derivate |
IT1224416B (it) * | 1987-12-24 | 1990-10-04 | Bracco Ind Chimica Spa | Chelanti macrociclici e loro chelati |
US5132409A (en) * | 1987-01-12 | 1992-07-21 | Bracco Industria Chimica S.P.A. | Macrocyclic chelating agents and chelates thereof |
FR2637895B1 (fr) * | 1988-10-14 | 1992-11-06 | Guerbet Sa | Nouveaux ligands cycliques azotes, complexes metalliques formes par ces ligands, compositions de diagnostic contenant ces complexes et procede de preparation des ligands |
FR2614020B1 (fr) * | 1987-04-14 | 1989-07-28 | Guerbet Sa | Nouveaux ligands cycliques azotes, complexes metalliques formes par ces ligands, compositions de diagnostic contenant ces complexes et procede de preparation des ligands. |
US5049667A (en) * | 1987-04-14 | 1991-09-17 | Guerbet S.A. | Nitrogen-containing cyclic ligands |
US5198208A (en) * | 1987-07-16 | 1993-03-30 | Nycomed Imaging As | Aminopolycarboxylic acids and derivatives thereof |
DE3728525A1 (de) * | 1987-08-24 | 1989-03-16 | Schering Ag | Mehrkernige substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel |
US4889931A (en) * | 1988-09-27 | 1989-12-26 | Salutar, Inc. | Manganese (II) chelate manufacture |
AU625529B2 (en) * | 1989-12-22 | 1992-07-16 | E.R. Squibb & Sons, Inc. | 10-(2'-hydroxy-3'-alkoxy-1,4,7-triscarboxymethyl-1,4,7,10- tetraazacyclododecanes |
AU6709390A (en) * | 1989-12-22 | 1991-06-27 | E.R. Squibb & Sons, Inc. | 10-(2'-hydroxy-3'-polyoxaalkyl)-1,4,7-tris-carboxymethyl -1,4,7,10-tetraazacyclododecane |
DE4009119A1 (de) * | 1990-03-19 | 1991-09-26 | Schering Ag | 1,4,7,10-tetraazacyclododecan-butyltriole, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
US5262532A (en) * | 1991-07-22 | 1993-11-16 | E.R. Squibb & Sons, Inc. | Paramagnetic metalloporphyrins as contrast agents for magnetic resonance imaging |
-
1990
- 1990-11-08 DE DE4035760A patent/DE4035760A1/de not_active Withdrawn
-
1991
- 1991-11-07 EP EP91250305A patent/EP0485045B1/de not_active Expired - Lifetime
- 1991-11-07 NO NO91914356A patent/NO914356L/no unknown
- 1991-11-07 JP JP03318548A patent/JP3137700B2/ja not_active Expired - Fee Related
- 1991-11-07 PT PT99445A patent/PT99445B/pt not_active IP Right Cessation
- 1991-11-07 ES ES91250305T patent/ES2128307T3/es not_active Expired - Lifetime
- 1991-11-07 DK DK91250305T patent/DK0485045T3/da active
- 1991-11-07 CA CA002055093A patent/CA2055093A1/en not_active Abandoned
- 1991-11-07 DE DE59109082T patent/DE59109082D1/de not_active Expired - Lifetime
- 1991-11-07 AT AT91250305T patent/ATE175201T1/de not_active IP Right Cessation
- 1991-11-08 IL IL100015A patent/IL100015A0/xx unknown
- 1991-11-08 AU AU87726/91A patent/AU8772691A/en not_active Abandoned
- 1991-11-08 IE IE389991A patent/IE913899A1/en not_active IP Right Cessation
- 1991-11-08 US US07/789,178 patent/US5277895A/en not_active Expired - Lifetime
- 1991-11-08 FI FI915282A patent/FI915282A/fi not_active Application Discontinuation
- 1991-11-08 ZA ZA918893A patent/ZA918893B/xx unknown
-
1994
- 1994-01-10 US US08/179,552 patent/US5871709A/en not_active Expired - Lifetime
-
1999
- 1999-03-23 GR GR990400863T patent/GR3029775T3/el unknown
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008134289A2 (en) * | 2007-04-26 | 2008-11-06 | Mallinckrodt Inc. | High relaxivity coordinatively unsaturated lanthanide complexes |
WO2008134289A3 (en) * | 2007-04-26 | 2008-12-11 | Mallinckrodt Inc | High relaxivity coordinatively unsaturated lanthanide complexes |
Also Published As
Publication number | Publication date |
---|---|
PT99445A (pt) | 1992-09-30 |
PT99445B (pt) | 1999-04-30 |
NO914356D0 (no) | 1991-11-07 |
AU8772691A (en) | 1992-05-14 |
JP3137700B2 (ja) | 2001-02-26 |
DE4035760A1 (de) | 1992-05-14 |
EP0485045B1 (de) | 1998-12-30 |
GR3029775T3 (en) | 1999-06-30 |
FI915282A0 (fi) | 1991-11-08 |
EP0485045A2 (de) | 1992-05-13 |
IE913899A1 (en) | 1992-05-20 |
JPH04288063A (ja) | 1992-10-13 |
DE59109082D1 (de) | 1999-02-11 |
ZA918893B (en) | 1992-08-26 |
DK0485045T3 (da) | 1999-08-30 |
ES2128307T3 (es) | 1999-05-16 |
NO914356L (no) | 1992-05-11 |
US5277895A (en) | 1994-01-11 |
EP0485045A3 (en) | 1992-10-28 |
ATE175201T1 (de) | 1999-01-15 |
US5871709A (en) | 1999-02-16 |
FI915282A (fi) | 1992-05-09 |
IL100015A0 (en) | 1992-08-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued | ||
FZDE | Discontinued |
Effective date: 19940507 |