CA2049129A1 - Haemophilus paragallinarum vaccine - Google Patents
Haemophilus paragallinarum vaccineInfo
- Publication number
- CA2049129A1 CA2049129A1 CA002049129A CA2049129A CA2049129A1 CA 2049129 A1 CA2049129 A1 CA 2049129A1 CA 002049129 A CA002049129 A CA 002049129A CA 2049129 A CA2049129 A CA 2049129A CA 2049129 A1 CA2049129 A1 CA 2049129A1
- Authority
- CA
- Canada
- Prior art keywords
- vaccine
- paragallinarum
- protein
- cells
- haemophilus paragallinarum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 241000606767 Avibacterium paragallinarum Species 0.000 title claims abstract description 60
- 229960005486 vaccine Drugs 0.000 title claims abstract description 57
- 208000015181 infectious disease Diseases 0.000 claims abstract description 21
- 244000144977 poultry Species 0.000 claims abstract description 8
- 238000002360 preparation method Methods 0.000 claims description 38
- 235000018102 proteins Nutrition 0.000 claims description 31
- 102000004169 proteins and genes Human genes 0.000 claims description 31
- 108090000623 proteins and genes Proteins 0.000 claims description 31
- 239000000463 material Substances 0.000 claims description 17
- 239000012528 membrane Substances 0.000 claims description 13
- 230000003053 immunization Effects 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 11
- 239000002671 adjuvant Substances 0.000 claims description 8
- 241001465754 Metazoa Species 0.000 claims description 7
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 claims description 6
- 230000001900 immune effect Effects 0.000 claims description 5
- 230000002458 infectious effect Effects 0.000 claims description 5
- 230000000890 antigenic effect Effects 0.000 claims description 4
- 230000002163 immunogen Effects 0.000 claims description 3
- 244000005700 microbiome Species 0.000 claims description 2
- 235000004252 protein component Nutrition 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 241000287828 Gallus gallus Species 0.000 abstract description 19
- 235000013330 chicken meat Nutrition 0.000 abstract description 19
- 235000013594 poultry meat Nutrition 0.000 abstract description 5
- 101710116435 Outer membrane protein Proteins 0.000 abstract description 3
- 230000001681 protective effect Effects 0.000 description 17
- 241000271566 Aves Species 0.000 description 14
- 210000004027 cell Anatomy 0.000 description 13
- 241000894006 Bacteria Species 0.000 description 9
- 238000002255 vaccination Methods 0.000 description 9
- 238000002955 isolation Methods 0.000 description 8
- 238000002649 immunization Methods 0.000 description 7
- 239000000203 mixture Substances 0.000 description 5
- 150000007523 nucleic acids Chemical group 0.000 description 5
- 229940031626 subunit vaccine Drugs 0.000 description 5
- 238000011282 treatment Methods 0.000 description 5
- 229940031418 trivalent vaccine Drugs 0.000 description 5
- 230000002238 attenuated effect Effects 0.000 description 4
- 235000013601 eggs Nutrition 0.000 description 4
- 238000005194 fractionation Methods 0.000 description 4
- 238000000746 purification Methods 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 3
- 108010067770 Endopeptidase K Proteins 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 206010039101 Rhinorrhoea Diseases 0.000 description 3
- 108090000631 Trypsin Proteins 0.000 description 3
- 102000004142 Trypsin Human genes 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 239000012634 fragment Substances 0.000 description 3
- 230000028993 immune response Effects 0.000 description 3
- 208000010753 nasal discharge Diseases 0.000 description 3
- 239000012588 trypsin Substances 0.000 description 3
- 108020004414 DNA Proteins 0.000 description 2
- 241000283073 Equus caballus Species 0.000 description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- 239000007330 chocolate agar Substances 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- 239000003599 detergent Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000002158 endotoxin Substances 0.000 description 2
- 230000006862 enzymatic digestion Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 244000144992 flock Species 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 239000002480 mineral oil Substances 0.000 description 2
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 2
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- 210000002345 respiratory system Anatomy 0.000 description 2
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 description 2
- 238000004062 sedimentation Methods 0.000 description 2
- 238000000527 sonication Methods 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 2
- 229940033663 thimerosal Drugs 0.000 description 2
- 108010042708 Acetylmuramyl-Alanyl-Isoglutamine Proteins 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N Arginine Chemical compound OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 241000711404 Avian avulavirus 1 Species 0.000 description 1
- 241000537222 Betabaculovirus Species 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 102000003846 Carbonic anhydrases Human genes 0.000 description 1
- 108090000209 Carbonic anhydrases Proteins 0.000 description 1
- 108010026206 Conalbumin Proteins 0.000 description 1
- 206010010741 Conjunctivitis Diseases 0.000 description 1
- 102000018832 Cytochromes Human genes 0.000 description 1
- 108010052832 Cytochromes Proteins 0.000 description 1
- 108010041986 DNA Vaccines Proteins 0.000 description 1
- 208000000666 Fowlpox Diseases 0.000 description 1
- 241000711450 Infectious bronchitis virus Species 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 241000204031 Mycoplasma Species 0.000 description 1
- 241000204022 Mycoplasma gallisepticum Species 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 108010077895 Sarcosine Proteins 0.000 description 1
- 206010044302 Tracheitis Diseases 0.000 description 1
- 229920004890 Triton X-100 Polymers 0.000 description 1
- 239000013504 Triton X-100 Substances 0.000 description 1
- 210000004712 air sac Anatomy 0.000 description 1
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 1
- 229910021502 aluminium hydroxide Inorganic materials 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- 150000001413 amino acids Chemical group 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000012888 bovine serum Substances 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- 108010079058 casein hydrolysate Proteins 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 210000002969 egg yolk Anatomy 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 230000000763 evoking effect Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 238000001502 gel electrophoresis Methods 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 208000037824 growth disorder Diseases 0.000 description 1
- 210000004408 hybridoma Anatomy 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 229940031551 inactivated vaccine Drugs 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 201000009837 laryngotracheitis Diseases 0.000 description 1
- 229940023832 live vector-vaccine Drugs 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 230000008774 maternal effect Effects 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 239000002808 molecular sieve Substances 0.000 description 1
- 229940031346 monovalent vaccine Drugs 0.000 description 1
- BSOQXXWZTUDTEL-ZUYCGGNHSA-N muramyl dipeptide Chemical compound OC(=O)CC[C@H](C(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](C)O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](O)[C@@H]1NC(C)=O BSOQXXWZTUDTEL-ZUYCGGNHSA-N 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 229920000447 polyanionic polymer Polymers 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 229940043230 sarcosine Drugs 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 235000020183 skimmed milk Nutrition 0.000 description 1
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
- KSAVQLQVUXSOCR-UHFFFAOYSA-M sodium lauroyl sarcosinate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O KSAVQLQVUXSOCR-UHFFFAOYSA-M 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 210000004989 spleen cell Anatomy 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000036435 stunted growth Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/285—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1242—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/826—Bacterial vaccine for avian species, e.g. poultry or other birds
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP90.202.358.9 | 1990-09-05 | ||
| EP90202358 | 1990-09-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2049129A1 true CA2049129A1 (en) | 1992-03-06 |
Family
ID=8205111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002049129A Abandoned CA2049129A1 (en) | 1990-09-05 | 1991-08-13 | Haemophilus paragallinarum vaccine |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5240705A (hu) |
| EP (1) | EP0475478B1 (hu) |
| JP (1) | JPH0592929A (hu) |
| KR (1) | KR920006004A (hu) |
| CN (1) | CN1059471A (hu) |
| AU (1) | AU640516B2 (hu) |
| CA (1) | CA2049129A1 (hu) |
| DE (1) | DE69110997T2 (hu) |
| HU (2) | HU210851B (hu) |
| IL (1) | IL99097A0 (hu) |
| MX (1) | MX9100654A (hu) |
| NZ (1) | NZ239654A (hu) |
| ZA (1) | ZA916237B (hu) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994005783A1 (en) * | 1992-09-07 | 1994-03-17 | Bioproperties (Australia) Pty. Limited | Novel haemophilus organism and vaccines containing the same |
| EP0625190B1 (en) * | 1992-10-14 | 1996-12-27 | Akzo Nobel N.V. | New bacterium causing poultry disease and vaccine derived thereof |
| GB9521568D0 (en) * | 1995-10-20 | 1995-12-20 | Lynxvale Ltd | Delivery of biologically active polypeptides |
| JPH1084969A (ja) * | 1996-09-19 | 1998-04-07 | Chemo Sero Therapeut Res Inst | ヘモフィルス・パラガリナルム由来新規ポリペプチド及びその製法 |
| US7780961B2 (en) * | 2001-05-03 | 2010-08-24 | Actogenix N.V. | Self-containing Lactococcus strain |
| JP2005529622A (ja) * | 2002-06-19 | 2005-10-06 | ヴェーイーベー・ヴェーゼットウェー | 腸吸収を促進するための方法および手段 |
| AU2003298291A1 (en) * | 2002-11-15 | 2004-06-15 | Universiteit Gent | Self-containing lactobacillus strain |
| DK2119450T3 (da) | 2005-11-29 | 2013-05-06 | Actogenix Nv | Induktion af mucosal tolerance over for pankreatisk ø-beta-celle-autoantigener |
| ES2492468T3 (es) | 2007-01-25 | 2014-09-09 | Actogenix N.V. | Tratamiento de enfermedad inmunitaria por administración a través de la mucosa de antígenos usando Lactobacillus genéticamente modificado |
| EP2382985B1 (en) * | 2008-12-25 | 2015-05-06 | The Chemo-Sero-Therapeutic Research Institute | Recombinant avian-infectious coryza vaccine and method for producing same |
| CN104212736A (zh) * | 2013-09-30 | 2014-12-17 | 郑州后羿制药有限公司 | 一种副鸡嗜血杆菌、灭活疫苗及其制备方法 |
| CN107354114A (zh) * | 2017-09-02 | 2017-11-17 | 河南省农业科学院畜牧兽医研究所 | 一株副鸡嗜血杆菌及其应用 |
| CN111471619A (zh) * | 2020-04-15 | 2020-07-31 | 北京家禽育种有限公司 | 一种用于副鸡禽杆菌实验室分离培养的培养基及其制备方法和应用 |
| RU2752315C1 (ru) * | 2020-07-31 | 2021-07-26 | Федеральное государственное бюджетное научное учреждение "Федеральный научный центр - Всероссийский научно-исследовательский институт экспериментальной ветеринарии имени К.И. Скрябина и Я.Р. Коваленко Российской академии наук" (ФГБНУ ФНЦ ВИЭВ РАН) | Вакцина против гемофилеза птиц инактивированная в форме суспензии "гемовак" |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3876763A (en) * | 1970-12-29 | 1975-04-08 | Shionogi & Co | Infectious coryza infectious bronchitis and newcastle disease vaccines and production thereof |
| JPS4823893B1 (hu) * | 1970-12-29 | 1973-07-17 | ||
| JPS6047650B2 (ja) * | 1976-06-22 | 1985-10-23 | ソニー株式会社 | 磁気記録媒体とその製法 |
| JPS54113422A (en) * | 1978-02-22 | 1979-09-05 | Shionogi & Co Ltd | Hemagglutinin of haemophilus gallinarum |
-
1991
- 1991-08-06 IL IL99097A patent/IL99097A0/xx unknown
- 1991-08-07 ZA ZA916237A patent/ZA916237B/xx unknown
- 1991-08-08 DE DE69110997T patent/DE69110997T2/de not_active Expired - Fee Related
- 1991-08-08 EP EP91202039A patent/EP0475478B1/en not_active Expired - Lifetime
- 1991-08-13 CA CA002049129A patent/CA2049129A1/en not_active Abandoned
- 1991-08-14 MX MX9100654A patent/MX9100654A/es not_active IP Right Cessation
- 1991-08-28 AU AU83474/91A patent/AU640516B2/en not_active Ceased
- 1991-08-29 US US07/751,492 patent/US5240705A/en not_active Expired - Fee Related
- 1991-09-03 NZ NZ239654A patent/NZ239654A/en unknown
- 1991-09-04 CN CN91108663A patent/CN1059471A/zh active Pending
- 1991-09-04 JP JP3224128A patent/JPH0592929A/ja active Pending
- 1991-09-04 HU HU912864A patent/HU210851B/hu not_active IP Right Cessation
- 1991-09-04 KR KR1019910015409A patent/KR920006004A/ko not_active Application Discontinuation
-
1995
- 1995-06-29 HU HU95P/P00562P patent/HU211829A9/hu unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR920006004A (ko) | 1992-04-27 |
| EP0475478B1 (en) | 1995-07-05 |
| DE69110997T2 (de) | 1995-12-07 |
| JPH0592929A (ja) | 1993-04-16 |
| HU211829A9 (en) | 1995-12-28 |
| NZ239654A (en) | 1993-01-27 |
| HU912864D0 (en) | 1992-01-28 |
| CN1059471A (zh) | 1992-03-18 |
| HU210851B (en) | 1995-08-28 |
| MX9100654A (es) | 1992-06-05 |
| DE69110997D1 (de) | 1995-08-10 |
| AU8347491A (en) | 1992-03-12 |
| ZA916237B (en) | 1992-05-27 |
| AU640516B2 (en) | 1993-08-26 |
| US5240705A (en) | 1993-08-31 |
| EP0475478A1 (en) | 1992-03-18 |
| HUT61488A (en) | 1993-01-28 |
| IL99097A0 (en) | 1992-07-15 |
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