CA2027592A1 - Preparations pharmaceutiques solides de la forme active de la vitamine d_ a stabilite amelioree - Google Patents

Preparations pharmaceutiques solides de la forme active de la vitamine d_ a stabilite amelioree

Info

Publication number
CA2027592A1
CA2027592A1 CA2027592A CA2027592A CA2027592A1 CA 2027592 A1 CA2027592 A1 CA 2027592A1 CA 2027592 A CA2027592 A CA 2027592A CA 2027592 A CA2027592 A CA 2027592A CA 2027592 A1 CA2027592 A1 CA 2027592A1
Authority
CA
Canada
Prior art keywords
vitamin
active form
improved stability
pharmaceutical preparations
solid pharmaceutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2027592A
Other languages
English (en)
Other versions
CA2027592C (fr
Inventor
Yuji Makino
Yoshiki Suzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2027592A1 publication Critical patent/CA2027592A1/fr
Application granted granted Critical
Publication of CA2027592C publication Critical patent/CA2027592C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CA002027592A 1989-03-01 1990-02-28 Preparations pharmaceutiques solides de la forme active de la vitamine d_ a stabilite amelioree Expired - Fee Related CA2027592C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP1046571A JP2525478B2 (ja) 1989-03-01 1989-03-01 安定性の改良された活性型ビタミンｄ▲下３▼類固型製剤
JP1-46571 1989-03-01

Publications (2)

Publication Number Publication Date
CA2027592A1 true CA2027592A1 (fr) 1990-09-02
CA2027592C CA2027592C (fr) 1996-11-26

Family

ID=12751003

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002027592A Expired - Fee Related CA2027592C (fr) 1989-03-01 1990-02-28 Preparations pharmaceutiques solides de la forme active de la vitamine d_ a stabilite amelioree

Country Status (10)

Country Link
US (1) US5158944A (fr)
EP (1) EP0413828B1 (fr)
JP (1) JP2525478B2 (fr)
KR (2) KR930010621B1 (fr)
AT (1) ATE136782T1 (fr)
CA (1) CA2027592C (fr)
DE (1) DE69026555T2 (fr)
DK (1) DK0413828T3 (fr)
ES (1) ES2085905T3 (fr)
WO (1) WO1990009796A1 (fr)

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JP2845342B2 (ja) * 1990-04-28 1999-01-13 大正製薬株式会社 ビタミンｄ▲下３▼誘導体含有固形製剤組成物
CA2061520C (fr) * 1991-03-27 2003-04-22 Lawrence J. Daher Systeme de delivrance accelerant l'effet et accroissant la puissance
NZ242271A (en) * 1991-04-09 1993-10-26 Takeda Chemical Industries Ltd Medicaments containing a vitamin d compound stabilised by a basic substance
KR100274734B1 (ko) * 1991-11-22 2000-12-15 제이코버스 코넬리스 레이서 리제드로네이트 지연-방출성 조성물
US6096342A (en) 1997-03-12 2000-08-01 The Procter & Gamble Company Dosage forms of risedronate
AU3095492A (en) * 1991-12-11 1993-07-19 Central Glass Co., Ltd. 24,25-dihydroxyvitamin D3 derivative
IL103224A (en) * 1992-09-18 1998-08-16 Teva Pharma Stabilized pharmaceutical compositions containing derivatives of vitamins d2 and d3
US6406714B1 (en) 1992-12-02 2002-06-18 Merck & Co., Inc. Dry mix formulation for bisphosphonic acids
US5358941A (en) * 1992-12-02 1994-10-25 Merck & Co., Inc. Dry mix formulation for bisphosphonic acids with lactose
US6103709A (en) * 1993-12-23 2000-08-15 The Regents Of The University Of California Therapeutically effective 1α,25-dihydroxyvitamin D3 analogs and methods for treatment of vitamin D diseases
FR2724844B1 (fr) * 1994-09-23 1997-01-24 Innothera Lab Sa Association therapeutique vitamino-calcique, son procede d'obtention et son utilisation
US6716454B2 (en) 1994-09-23 2004-04-06 Laboratorie Innothera, Société Anonyme Therapeutic combination of vitamin and calcium in unitary galenic tablet form, a method of obtaining it, and the use thereof
US5698222A (en) * 1995-04-07 1997-12-16 Abbott Laboratories Calcium supplement
US6395770B1 (en) 1995-10-26 2002-05-28 Baker Norton Pharmaceuticals, Inc. Method and compositions for administering taxanes orally to human patients
US6245805B1 (en) 1995-10-26 2001-06-12 Baker Norton Pharmaceuticals, Inc. Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents
AT408416B (de) * 1996-07-19 2001-11-26 Norbert Fuchs Pharmazeutische bzw. diätetische zusammensetzungen
FI120290B (fi) * 1996-12-30 2009-09-15 Mirador Res Oy Ltd Menetelmä, jonka avulla voidaan valmistaa sellaisia mausteseos-, ruoan ainesosa- ja elintarvikekoostumuksia, jotka alentavat seerumin kolesterolia
DE19710054A1 (de) * 1997-03-12 1998-09-17 Merck Patent Gmbh Pharmazeutische Zubereitung
AR024462A1 (es) 1999-07-01 2002-10-02 Merck & Co Inc Tabletas farmaceuticas
US20030158158A1 (en) * 2000-08-30 2003-08-21 Ichiro Fujimoto Oct preparations
KR100688618B1 (ko) * 2001-09-12 2007-03-09 주식회사 유유 비타민 ｄ 경구투여용 서방성 약제 조성물
BR0214679A (pt) * 2001-12-03 2004-12-14 Novacea Inc Composições farmacêuticas compreendendo compostos a base de vitamina d ativa
US20040053895A1 (en) * 2002-09-18 2004-03-18 Bone Care International, Inc. Multi-use vessels for vitamin D formulations
US7148211B2 (en) * 2002-09-18 2006-12-12 Genzyme Corporation Formulation for lipophilic agents
US20040058895A1 (en) * 2002-09-18 2004-03-25 Bone Care International, Inc. Multi-use vessels for vitamin D formulations
US20060189586A1 (en) * 2003-06-11 2006-08-24 Cleland Jeffrey L Pharmaceutical compositions comprising active vitamin D compounds
CA2882048C (fr) 2006-02-03 2020-03-24 Proventiv Therapeutics, Llc Traitement de l'insuffisance et de la deficience de vitamine d avec de la 25-hydroxyvitamine d2 et de la 25-hydroxyvitamine d3
DK3357496T3 (da) 2006-06-21 2020-05-11 Opko Ireland Global Holdings Ltd Terapi ved brug af vitamin d-repletteringsmiddel og vitamin d-hormonsubstitutionsmiddel
KR101495578B1 (ko) 2007-04-25 2015-02-25 사이토크로마 인코포레이티드 비타민 ｄ 부족 및 결핍의 치료 방법
ES2956794T3 (es) 2007-04-25 2023-12-28 Eirgen Pharma Ltd Liberación controlada de 25-hidroxivitamina D
EP2240036B1 (fr) * 2008-02-06 2015-01-14 Innov'ia Composition pulvérulente et son procédé de préparation
EP3636280A1 (fr) 2010-03-29 2020-04-15 Opko Ireland Global Holdings, Ltd. Méthodes et compositions pour la réduction des niveaux parathyroïdiens
EP2468265A3 (fr) * 2010-12-04 2013-01-02 DEEF Pharmaceutical Industries Co. Préparations homogènes contenant de la vitamine D
KR101847947B1 (ko) 2013-03-15 2018-05-28 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 안정화되고 변형된 비타민 ｄ 방출 제형
US10220047B2 (en) 2014-08-07 2019-03-05 Opko Ireland Global Holdings, Ltd. Adjunctive therapy with 25-hydroxyvitamin D and articles therefor
JP7034595B2 (ja) * 2016-03-23 2022-03-14 株式会社ファンケル ビタミンｄ３安定化組成物
KR20180123100A (ko) 2016-03-28 2018-11-14 옵코 아일랜드 글로벌 홀딩스 리미티드 비타민 d 치료 방법
KR102366186B1 (ko) 2016-12-28 2022-02-21 추가이 세이야쿠 가부시키가이샤 Ed-71의 고체 분산체 및 유분 분산체를 포함하는 의약 조성물
US11638439B2 (en) * 2018-05-21 2023-05-02 Agthia Vitamin D-fortified water and method of manufacturing thereof
KR102708351B1 (ko) 2018-06-27 2024-09-20 추가이 세이야쿠 가부시키가이샤 유지 중에 ed-71 및 그의 에폭시체를 포함하는 유분 분산체를 포함하는 의약 조성물

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Also Published As

Publication number Publication date
EP0413828A1 (fr) 1991-02-27
CA2027592C (fr) 1996-11-26
KR920700036A (ko) 1992-02-19
JP2525478B2 (ja) 1996-08-21
ES2085905T3 (es) 1996-06-16
ATE136782T1 (de) 1996-05-15
KR930010621B1 (ko) 1993-11-02
DE69026555D1 (de) 1996-05-23
WO1990009796A1 (fr) 1990-09-07
DE69026555T2 (de) 1996-09-19
EP0413828B1 (fr) 1996-04-17
JPH02229115A (ja) 1990-09-11
EP0413828A4 (en) 1991-10-30
DK0413828T3 (da) 1996-05-13
US5158944A (en) 1992-10-27

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EEER Examination request
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