JPS5740461A - Novel activated vitamin d3 derivative composition - Google Patents
Novel activated vitamin d3 derivative compositionInfo
- Publication number
- JPS5740461A JPS5740461A JP11582480A JP11582480A JPS5740461A JP S5740461 A JPS5740461 A JP S5740461A JP 11582480 A JP11582480 A JP 11582480A JP 11582480 A JP11582480 A JP 11582480A JP S5740461 A JPS5740461 A JP S5740461A
- Authority
- JP
- Japan
- Prior art keywords
- derivative
- activated vitamin
- vitamin
- derivative composition
- sterol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To prepare the titled composition containing a vitamine D3 derivative having remarkably improved chemical stability, by compounding a specific activated vitamin D3 derivative effective to rachitis, osteomalacia, etc., and a sterol compound.
CONSTITUTION: At least one activated vitamin D3 derivative selected from the hydroxycholecalciferols of formula (R1WR3 are H or OH, provided that at least one of R1WR3 is OH) is made to react with a sterol in a solvent such as ethanol. After the reaction, the reaction product is precipitated by the addition of water, saline water, etc. or by the concentration, cooling, etc. The composition thus obtained is administered in the form of e.g. tablet, capsule, liquid, etc. The vitamin D3 derivative can be remarkably stabilized against heat, light, oxidation, etc. by reacting with sterols.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11582480A JPS5740461A (en) | 1980-08-25 | 1980-08-25 | Novel activated vitamin d3 derivative composition |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11582480A JPS5740461A (en) | 1980-08-25 | 1980-08-25 | Novel activated vitamin d3 derivative composition |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5740461A true JPS5740461A (en) | 1982-03-06 |
JPS6251948B2 JPS6251948B2 (en) | 1987-11-02 |
Family
ID=14672010
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP11582480A Granted JPS5740461A (en) | 1980-08-25 | 1980-08-25 | Novel activated vitamin d3 derivative composition |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5740461A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6176416A (en) * | 1984-09-20 | 1986-04-18 | Fujimoto Seiyaku Kk | Activated type vitamin d3 derivative composition for encapsulation |
JPS61194065A (en) * | 1985-02-21 | 1986-08-28 | Taisho Pharmaceut Co Ltd | Vitamin d3 derivative |
JPS6431722A (en) * | 1987-07-22 | 1989-02-02 | Teva Pharma | Composition of cholecalciferol derivative for treating renal bone disease |
JPH02229115A (en) * | 1989-03-01 | 1990-09-11 | Teijin Ltd | Solid pharmaceutical of active type vitamin d3s improved in stability |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990003173A1 (en) * | 1988-09-26 | 1990-04-05 | Teijin Limited | Stable aqueous preparation of active vitamin d¿3? |
-
1980
- 1980-08-25 JP JP11582480A patent/JPS5740461A/en active Granted
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6176416A (en) * | 1984-09-20 | 1986-04-18 | Fujimoto Seiyaku Kk | Activated type vitamin d3 derivative composition for encapsulation |
JPH0437803B2 (en) * | 1984-09-20 | 1992-06-22 | Fujimoto Seiyaku Kk | |
JPS61194065A (en) * | 1985-02-21 | 1986-08-28 | Taisho Pharmaceut Co Ltd | Vitamin d3 derivative |
JPS6431722A (en) * | 1987-07-22 | 1989-02-02 | Teva Pharma | Composition of cholecalciferol derivative for treating renal bone disease |
JPH02229115A (en) * | 1989-03-01 | 1990-09-11 | Teijin Ltd | Solid pharmaceutical of active type vitamin d3s improved in stability |
Also Published As
Publication number | Publication date |
---|---|
JPS6251948B2 (en) | 1987-11-02 |
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