CA2008824A1 - Methode de production du glucagon - Google Patents

Methode de production du glucagon

Info

Publication number
CA2008824A1
CA2008824A1 CA2008824A CA2008824A CA2008824A1 CA 2008824 A1 CA2008824 A1 CA 2008824A1 CA 2008824 A CA2008824 A CA 2008824A CA 2008824 A CA2008824 A CA 2008824A CA 2008824 A1 CA2008824 A1 CA 2008824A1
Authority
CA
Canada
Prior art keywords
glucagon
fusion protein
glu
glutamic acid
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2008824A
Other languages
English (en)
Other versions
CA2008824C (fr
Inventor
Jun Ishizaki
Mikio Tamaki
Masaru Shin
Hiroshi Teraoka
Nobuo Yoshida
Hiroshige Tsuzuki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shionogi and Co Ltd
Original Assignee
Jun Ishizaki
Mikio Tamaki
Masaru Shin
Hiroshi Teraoka
Nobuo Yoshida
Hiroshige Tsuzuki
Shionogi & Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jun Ishizaki, Mikio Tamaki, Masaru Shin, Hiroshi Teraoka, Nobuo Yoshida, Hiroshige Tsuzuki, Shionogi & Co., Ltd. filed Critical Jun Ishizaki
Publication of CA2008824A1 publication Critical patent/CA2008824A1/fr
Application granted granted Critical
Publication of CA2008824C publication Critical patent/CA2008824C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/57—IFN-gamma
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Control Of El Displays (AREA)
  • Earth Drilling (AREA)
  • Diaphragms And Bellows (AREA)
  • Separation By Low-Temperature Treatments (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002008824A 1989-02-01 1990-01-29 Methode de production du glucagon Expired - Fee Related CA2008824C (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP1-24158 1989-02-01
JP2415889 1989-02-01

Publications (2)

Publication Number Publication Date
CA2008824A1 true CA2008824A1 (fr) 1990-08-01
CA2008824C CA2008824C (fr) 1997-08-05

Family

ID=12130531

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002008824A Expired - Fee Related CA2008824C (fr) 1989-02-01 1990-01-29 Methode de production du glucagon

Country Status (18)

Country Link
EP (1) EP0381433B1 (fr)
JP (1) JPH0748999B2 (fr)
KR (1) KR0161656B1 (fr)
CN (1) CN1063795C (fr)
AT (1) ATE144551T1 (fr)
BR (1) BR9000445A (fr)
CA (1) CA2008824C (fr)
DE (1) DE69028935T2 (fr)
DK (1) DK0381433T3 (fr)
ES (1) ES2095236T3 (fr)
FI (1) FI900497A0 (fr)
GR (1) GR3021965T3 (fr)
HU (1) HUT54410A (fr)
IL (1) IL93173A0 (fr)
NO (1) NO900410L (fr)
NZ (1) NZ232255A (fr)
PT (1) PT93031A (fr)
ZA (1) ZA90533B (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6506595B2 (en) * 1998-03-31 2003-01-14 Itoham Foods Inc. DNAs encoding new fusion proteins and processes for preparing useful polypeptides through expression of the DNAs

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100480374C (zh) * 2001-09-28 2009-04-22 中国科学院上海生命科学研究院 制备重组人类胰高血糖素肽－1氨基酸7－37肽段的方法
EP2552950A1 (fr) * 2010-03-26 2013-02-06 Novo Nordisk A/S Nouveaux analogues du glucagon
EP2758426B1 (fr) 2011-09-23 2019-08-07 Novo Nordisk A/S Nouveaux analogues de glucagon
AU2014255608B2 (en) 2013-04-18 2018-01-25 Novo Nordisk A/S Stable, protracted GLP-1/glucagon receptor co-agonists for medical use
EP3151852A1 (fr) 2014-06-04 2017-04-12 Novo Nordisk A/S Co-agonistes de récepteur du glucagon/glp-1 à usage médical
CN104593399A (zh) * 2014-12-22 2015-05-06 广西大学 一种转基因胰岛素的合成工艺

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK27885A (da) * 1985-01-22 1986-07-23 Novo Industri As Fremstilling af peptider
US4743679A (en) * 1986-02-24 1988-05-10 Creative Biomolecules, Inc. Process for producing human epidermal growth factor and analogs thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6506595B2 (en) * 1998-03-31 2003-01-14 Itoham Foods Inc. DNAs encoding new fusion proteins and processes for preparing useful polypeptides through expression of the DNAs

Also Published As

Publication number Publication date
JPH0748999B2 (ja) 1995-05-31
BR9000445A (pt) 1991-01-15
NZ232255A (en) 1992-03-26
HUT54410A (en) 1991-02-28
IL93173A0 (en) 1990-11-05
DK0381433T3 (da) 1996-11-18
DE69028935T2 (de) 1997-03-06
CN1046559A (zh) 1990-10-31
DE69028935D1 (de) 1996-11-28
AU634999B2 (en) 1993-03-11
AU4898990A (en) 1990-08-09
CN1063795C (zh) 2001-03-28
FI900497A0 (fi) 1990-01-31
ZA90533B (en) 1990-10-31
KR0161656B1 (ko) 1998-11-16
ES2095236T3 (es) 1997-02-16
PT93031A (pt) 1990-08-31
HU900614D0 (en) 1990-04-28
NO900410D0 (no) 1990-01-29
KR900013077A (ko) 1990-09-03
JPH03254692A (ja) 1991-11-13
CA2008824C (fr) 1997-08-05
EP0381433A1 (fr) 1990-08-08
NO900410L (no) 1990-08-02
ATE144551T1 (de) 1996-11-15
EP0381433B1 (fr) 1996-10-23
GR3021965T3 (en) 1997-03-31

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Legal Events

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