CA2001203A1 - Dithiocarbamoyl quinolones antimicrobiens - Google Patents
Dithiocarbamoyl quinolones antimicrobiensInfo
- Publication number
- CA2001203A1 CA2001203A1 CA2001203A CA2001203A CA2001203A1 CA 2001203 A1 CA2001203 A1 CA 2001203A1 CA 2001203 A CA2001203 A CA 2001203A CA 2001203 A CA2001203 A CA 2001203A CA 2001203 A1 CA2001203 A1 CA 2001203A1
- Authority
- CA
- Canada
- Prior art keywords
- heterocyclic ring
- ring
- heterocyclic
- carbocyclic ring
- dithiocarbamoyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000000845 anti-microbial effect Effects 0.000 title abstract 3
- 150000007660 quinolones Chemical class 0.000 title abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 7
- 125000002837 carbocyclic group Chemical group 0.000 abstract 4
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 150000004677 hydrates Chemical class 0.000 abstract 1
- LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical compound C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26194888A | 1988-10-24 | 1988-10-24 | |
US261,948 | 1988-10-24 | ||
US41802989A | 1989-10-12 | 1989-10-12 | |
US418,029 | 1989-10-12 |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2001203A1 true CA2001203A1 (fr) | 1990-04-24 |
CA2001203C CA2001203C (fr) | 2001-02-13 |
Family
ID=26948929
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002001203A Expired - Fee Related CA2001203C (fr) | 1988-10-24 | 1989-10-23 | Dithiocarbamoyl quinolones antimicrobiens |
Country Status (10)
Country | Link |
---|---|
US (2) | US5387748A (fr) |
EP (1) | EP0366643A3 (fr) |
JP (1) | JP2875015B2 (fr) |
KR (1) | KR900006333A (fr) |
AU (1) | AU631379B2 (fr) |
CA (1) | CA2001203C (fr) |
DK (1) | DK527789A (fr) |
NZ (1) | NZ231111A (fr) |
PH (1) | PH29981A (fr) |
WO (1) | WO1990004591A1 (fr) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5147871A (en) * | 1986-07-03 | 1992-09-15 | Hoffmann La-Roche, Inc. | Anti-bacterial cephalosporin compounds |
CS273349B2 (en) * | 1988-03-31 | 1991-03-12 | Hoffmann La Roche | Method of cephalosporin's new derivatives production |
US5336768A (en) * | 1988-05-24 | 1994-08-09 | Hoffmann-La Roche Inc. | Antibacterial cephalosporin compounds |
US5273973A (en) * | 1988-10-24 | 1993-12-28 | Norwich Eaton Pharmaceuticals, Inc. | Antimicrobial quinolonyl esters |
US5328908A (en) * | 1988-10-24 | 1994-07-12 | Procter & Gamble Pharmaceuticals, Inc. | Antimicrobial quinolone thioureas |
US5491139A (en) * | 1988-10-24 | 1996-02-13 | The Procter & Gamble Company | Antimicrobial quinolonyl lactams |
EP0366189A3 (fr) * | 1988-10-24 | 1992-01-02 | Norwich Eaton Pharmaceuticals, Inc. | Lactames-quinolones antimicrobiennes |
CA2001203C (fr) * | 1988-10-24 | 2001-02-13 | Thomas P. Demuth, Jr. | Dithiocarbamoyl quinolones antimicrobiens |
ATE176473T1 (de) * | 1988-10-24 | 1999-02-15 | Procter & Gamble Pharma | Antimikrobielle fluorochinolonylcephemderivate |
US5180719A (en) * | 1988-10-24 | 1993-01-19 | Norwich Eaton Pharmaceuticals, Inc. | Antimicrobial quinolonyl lactam esters |
US5162523A (en) * | 1989-07-21 | 1992-11-10 | Hoffmann-La Roche Inc. | Cephalosporin antibacterial compounds |
US5159077A (en) * | 1989-07-21 | 1992-10-27 | Hoffmann-La Roche Inc. | Penam antibacterial compounds |
EP0525057B1 (fr) * | 1990-04-18 | 2000-06-14 | Procter & Gamble Pharmaceuticals, Inc. | Quinolonyle lactames anti-microbiens |
KR950005301B1 (ko) * | 1990-09-04 | 1995-05-23 | 주식회사대웅제약 | 신규한 퀴놀론 카르복실산 유도체 |
WO1994025464A1 (fr) * | 1993-04-24 | 1994-11-10 | Korea Research Institute Of Chemical Technology | Nouveaux derives d'acide quinolone-carboxylique et leur procede de preparation |
JP3328936B2 (ja) * | 1993-09-03 | 2002-09-30 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | 5ht1dレセプター拮抗薬用インドールおよびインドリン誘導体 |
KR950018003A (ko) * | 1993-12-09 | 1995-07-22 | 스미스클라인 비참 피엘씨 | 신규한 퀴놀론 유도체 및 그의 제조 방법 |
KR20000035992A (ko) * | 1996-09-10 | 2000-06-26 | 메디녹스, 인크. | 폴리디티오카르바메이트 함유 거대분자 및 치료 및 진단을 위한 |
DE19652239A1 (de) * | 1996-12-16 | 1998-06-18 | Bayer Ag | Verwendung von 7-(2-Oxa-5,8-diazabicyclo[4.3.0]non-8-yl)-chinolon- und -naphthyridoncarbonsäure-Derivaten zur Therapie von Helicobacter-pylori-Infektionen und den damit assoziierten gastroduodenalen Erkrankungen |
SK286420B6 (sk) | 1997-09-15 | 2008-09-05 | The Procter & Gamble Company | Zlúčenina so štruktúrou chinolónu, farmaceutický prostriedok s jej obsahom a jej použitie |
JP2005504808A (ja) | 2001-09-26 | 2005-02-17 | バイエル・フアーマシユーチカルズ・コーポレーシヨン | 抗糖尿病薬としての1,6−ナフチリジン誘導体 |
UA84879C2 (ru) * | 2003-08-12 | 2008-12-10 | Акилайон Фармасьютикалз, Инк. | Изотиазолохинолоны и родственные соединения с противомикробным действием |
WO2006020573A2 (fr) * | 2004-08-11 | 2006-02-23 | Barbeau Donald L | Composes pharmaceutiques non cardiotoxiques |
CA2576589C (fr) * | 2004-08-13 | 2013-11-12 | Schering-Plough Ltd. | Formulation pharmaceutique comprenant un antibiotique, un triazole et un corticosteroide |
JP2008519842A (ja) * | 2004-11-11 | 2008-06-12 | アキリオン ファーマシューティカルズ,インコーポレーテッド | 抗感染剤としての8a,9−ジヒドロ−4a−h−イソチアゾロ[5,4−b]キノリン−3,4−ジオンおよび関連化合物 |
US7659399B2 (en) * | 2005-01-05 | 2010-02-09 | Achillion Pharmaceuticals, Inc. | 1-thia-2,4a-diaza-cyclopenta[b]napththalene-3,4-diones and related compounds as anti-infective agents |
WO2006084053A1 (fr) * | 2005-02-02 | 2006-08-10 | Achillion Pharmaceuticals, Inc. | 2h-isothiazolo[5,4-b]quinolizine-3,4-diones 8-n-substituees et composes relatifs servant d'agents anti-infectieux |
US8114888B2 (en) * | 2005-02-16 | 2012-02-14 | Achillion Pharmaceuticals, Inc. | Isothiazoloquinolones and related compounds as anti-infective agents |
KR101272263B1 (ko) * | 2005-07-27 | 2013-06-13 | 아칠리온 파르마세우티칼스 인코포레이티드 | 감염 방지제로서 사용되는8-메톡시-9h-이소티아졸로[5,4-b]퀴놀린-3,4-디온 및관련 화합물 |
ES2427247T3 (es) * | 2006-03-13 | 2013-10-30 | Kyorin Pharmaceutical Co., Ltd. | Aminoquinolonas como inhibidores de GSK-3 |
US7456279B2 (en) * | 2006-03-28 | 2008-11-25 | The Procter & Gamble Company | Coupling process for preparing quinolone intermediates |
AU2007230630B2 (en) * | 2006-03-28 | 2012-12-20 | Taigen Biotechnology Co., Ltd | Malate salts, and polymorphs of (3S,5S)-7-[3-amino-5-methyl-piperidinyl]-1-cyclopropyl-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid |
CN102351880B (zh) * | 2007-09-11 | 2014-11-12 | 杏林制药株式会社 | 作为gsk-3 抑制剂的氰基氨基喹诺酮和四唑并氨基喹诺酮 |
MX2010002662A (es) | 2007-09-12 | 2010-04-09 | Activx Biosciences Inc | Aminoquinolonas espirociclicas como inhibidores de gsk-3. |
EP2406266B1 (fr) * | 2009-03-11 | 2013-12-25 | Kyorin Pharmaceutical Co., Ltd. | 7-cycloalkylaminoquinolones comme inhibiteurs de la gsk-3 |
KR20120004510A (ko) * | 2009-04-03 | 2012-01-12 | 아칠리온 파르마세우티칼스 인코포레이티드 | 항감염제로서의 하이드록시티에노퀴놀론 및 관련 화합물 |
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JPS5219561Y2 (fr) * | 1971-03-05 | 1977-05-06 | ||
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JPS4935392A (fr) * | 1972-08-02 | 1974-04-01 | ||
JPS5023037A (fr) * | 1973-07-03 | 1975-03-12 | ||
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GB1509074A (en) * | 1974-04-05 | 1978-04-26 | Yamanouchi Pharma Co Ltd | Cephalosporin derivatives |
JPS53141286A (en) * | 1977-05-16 | 1978-12-08 | Kyorin Seiyaku Kk | Novel substituted quinolinecarboxylic acid |
JPS5573686A (en) * | 1978-11-28 | 1980-06-03 | Mitsui Toatsu Chem Inc | Novel penicillin |
JPS5732290A (en) * | 1980-08-06 | 1982-02-20 | Fujimoto Seiyaku Kk | Novel penicillin derivative and its preparation |
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EP0182210B1 (fr) * | 1984-11-12 | 1991-02-27 | Banyu Pharmaceutical Co., Ltd. | Dérivés de céphalosporine |
JPS6212760A (ja) * | 1984-12-14 | 1987-01-21 | Dai Ichi Seiyaku Co Ltd | 1−(2−ハロゲノシクロプロピル)キノリンカルボン酸誘導体 |
IT1215277B (it) * | 1985-05-27 | 1990-01-31 | Pomezia Roma A | Derivato chinolin-lattaminico ad attivita' antibatterica ed inibitrice delle b-lattamasi. |
DE3525108A1 (de) * | 1985-06-07 | 1986-12-11 | Bayer Ag, 5090 Leverkusen | Antibakteriell wirksame chinoloncarbonsaeureester |
NZ217650A (en) * | 1985-09-24 | 1989-09-27 | Hoffmann La Roche | Quinoline derivatives and pharmaceutical compositions |
GB8626245D0 (en) * | 1985-11-27 | 1986-12-03 | Ici Pharma | Cephalosporin compounds |
DE3542002A1 (de) * | 1985-11-28 | 1987-06-04 | Bayer Ag | 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7- (1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
DE3705621C2 (de) * | 1986-02-25 | 1997-01-09 | Otsuka Pharma Co Ltd | Heterocyclisch substituierte Chinoloncarbonsäurederivate |
DE3606698A1 (de) * | 1986-03-01 | 1987-09-03 | Bayer Ag | 7-(1-pyrrolidinyl)-chinoloncarbonsaeure -derivate |
US4783443A (en) * | 1986-03-03 | 1988-11-08 | The University Of Chicago | Amino acyl cephalosporin derivatives |
JPS62205060A (ja) * | 1986-03-04 | 1987-09-09 | Kyorin Pharmaceut Co Ltd | 8位置換キノロンカルボン酸誘導体 |
JPS62215572A (ja) * | 1986-03-17 | 1987-09-22 | Kyorin Pharmaceut Co Ltd | キノロンカルボン酸誘導体 |
JPS62274855A (ja) * | 1986-05-22 | 1987-11-28 | Nec Corp | 中継交換機の経路選択方式 |
JPS62274965A (ja) * | 1986-05-23 | 1987-11-28 | Nec Corp | ル−ト選択スケジユ−リング方法 |
ZA874696B (en) * | 1986-07-03 | 1988-01-04 | F. Hoffmann-La Roche & Co. Aktiengesellschaft | Acyl derivatives |
NZ222047A (en) * | 1986-10-08 | 1991-01-29 | Bristol Myers Co | Quinoline - or naphthyridine - carboxylic acid anti-bacterial agents |
US4954507A (en) * | 1986-10-08 | 1990-09-04 | Bristol-Myers Company | 1-tertiary-alkyl-substituted naphthyridine carboxylic acid antibacterial agents |
HU200917B (en) * | 1987-07-20 | 1990-09-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing pharmaceutical compositions comprising quinoline or naphthyridinecarboxylic acid and tetracycline derivatives as active ingredient |
DE3854684T2 (de) * | 1987-07-23 | 1996-03-28 | Zeneca Pharma Sa | Cephalosporinverbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate. |
GB8816519D0 (en) * | 1987-07-23 | 1988-08-17 | Ici Plc | Antibiotic compounds |
US4803205A (en) * | 1987-08-07 | 1989-02-07 | Warner-Lambert Company | Quinolones as antibacterial agents |
US4851418A (en) * | 1987-08-21 | 1989-07-25 | Warner-Lambert Company | Naphthyridine antibacterial agents containing an α-amino acid in the side chain of the 7-substituent |
NZ227470A (en) * | 1987-12-28 | 1991-06-25 | Hoffmann La Roche | Acyl derivatives of substituted cephem compounds; pharmaceutical compositions and methods for preparation and treatment |
HUT49889A (en) * | 1988-03-31 | 1989-11-28 | Hoffmann La Roche | Process for producing acyl derivatives |
US5336768A (en) * | 1988-05-24 | 1994-08-09 | Hoffmann-La Roche Inc. | Antibacterial cephalosporin compounds |
JPH01258684A (ja) * | 1988-04-07 | 1989-10-16 | Banyu Pharmaceut Co Ltd | 3‐置換キノリニウムチオメチルセファロスポリン誘導体 |
DE68919273T2 (de) * | 1988-05-10 | 1995-03-23 | Ici Plc | Cephalosporine, Verfahren zu ihrer Herstellung und pharmazeutische Präparate. |
US5328908A (en) * | 1988-10-24 | 1994-07-12 | Procter & Gamble Pharmaceuticals, Inc. | Antimicrobial quinolone thioureas |
US5273973A (en) * | 1988-10-24 | 1993-12-28 | Norwich Eaton Pharmaceuticals, Inc. | Antimicrobial quinolonyl esters |
EP0366193A3 (fr) * | 1988-10-24 | 1992-01-08 | Norwich Eaton Pharmaceuticals, Inc. | Quinolonyl-lactames antimicrobiennes |
EP0366189A3 (fr) * | 1988-10-24 | 1992-01-02 | Norwich Eaton Pharmaceuticals, Inc. | Lactames-quinolones antimicrobiennes |
ES2148135T3 (es) * | 1988-10-24 | 2000-10-16 | Norwich Eaton Pharma | Nuevos esteres antimicrobianos de quinolonil lactamas. |
ATE176473T1 (de) * | 1988-10-24 | 1999-02-15 | Procter & Gamble Pharma | Antimikrobielle fluorochinolonylcephemderivate |
CA2001203C (fr) * | 1988-10-24 | 2001-02-13 | Thomas P. Demuth, Jr. | Dithiocarbamoyl quinolones antimicrobiens |
ZA912279B (en) * | 1990-04-09 | 1992-02-26 | Hoffmann La Roche | Carbapenem compounds |
EP0525057B1 (fr) * | 1990-04-18 | 2000-06-14 | Procter & Gamble Pharmaceuticals, Inc. | Quinolonyle lactames anti-microbiens |
US5112967A (en) * | 1990-04-27 | 1992-05-12 | Hoffmann-La Roches Inc. | Process for synthesizing antibacterial cephalosporin compounds |
US5066800A (en) * | 1990-04-27 | 1991-11-19 | Hoffmann-La Roche Inc. | Qunoline intermediates useful therein for synthesizing antibacterial compounds |
-
1989
- 1989-10-23 CA CA002001203A patent/CA2001203C/fr not_active Expired - Fee Related
- 1989-10-24 KR KR1019890015237A patent/KR900006333A/ko not_active Application Discontinuation
- 1989-10-24 WO PCT/US1989/004806 patent/WO1990004591A1/fr unknown
- 1989-10-24 AU AU43685/89A patent/AU631379B2/en not_active Ceased
- 1989-10-24 EP EP19890870161 patent/EP0366643A3/fr not_active Ceased
- 1989-10-24 DK DK527789A patent/DK527789A/da not_active Application Discontinuation
- 1989-10-24 NZ NZ231111A patent/NZ231111A/en unknown
- 1989-10-24 PH PH39399A patent/PH29981A/en unknown
- 1989-10-24 JP JP2500634A patent/JP2875015B2/ja not_active Expired - Lifetime
-
1991
- 1991-05-02 US US07/696,985 patent/US5387748A/en not_active Expired - Fee Related
-
1994
- 1994-10-21 US US08/327,063 patent/US5672600A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JP2875015B2 (ja) | 1999-03-24 |
EP0366643A3 (fr) | 1991-12-04 |
CA2001203C (fr) | 2001-02-13 |
US5672600A (en) | 1997-09-30 |
KR900006333A (ko) | 1990-05-07 |
DK527789D0 (da) | 1989-10-24 |
AU631379B2 (en) | 1992-11-26 |
PH29981A (en) | 1996-10-29 |
DK527789A (da) | 1990-04-25 |
AU4368589A (en) | 1990-04-26 |
US5387748A (en) | 1995-02-07 |
WO1990004591A1 (fr) | 1990-05-03 |
EP0366643A2 (fr) | 1990-05-02 |
JPH03503533A (ja) | 1991-08-08 |
NZ231111A (en) | 1992-11-25 |
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EEER | Examination request | ||
MKLA | Lapsed |