CA1337345C - Process for the preparation of a thiazepine compound - Google Patents
Process for the preparation of a thiazepine compoundInfo
- Publication number
- CA1337345C CA1337345C CA000559825A CA559825A CA1337345C CA 1337345 C CA1337345 C CA 1337345C CA 000559825 A CA000559825 A CA 000559825A CA 559825 A CA559825 A CA 559825A CA 1337345 C CA1337345 C CA 1337345C
- Authority
- CA
- Canada
- Prior art keywords
- compound
- reaction
- formula
- effected
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D281/16—[b, f]-condensed
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8705574 | 1987-03-10 | ||
| GB878705574A GB8705574D0 (en) | 1987-03-10 | 1987-03-10 | Preparation of thiazepine compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1337345C true CA1337345C (en) | 1995-10-17 |
Family
ID=10613643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000559825A Expired - Lifetime CA1337345C (en) | 1987-03-10 | 1988-02-25 | Process for the preparation of a thiazepine compound |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP0282236B1 (fi) |
| JP (1) | JPH0688991B2 (fi) |
| KR (1) | KR960007088B1 (fi) |
| AR (1) | AR245707A1 (fi) |
| AT (1) | ATE70271T1 (fi) |
| AU (1) | AU595099B2 (fi) |
| CA (1) | CA1337345C (fi) |
| DD (1) | DD271703A5 (fi) |
| DE (1) | DE3866735D1 (fi) |
| DK (1) | DK175310B1 (fi) |
| ES (1) | ES2037822T3 (fi) |
| FI (1) | FI87778C (fi) |
| GB (2) | GB8705574D0 (fi) |
| GR (1) | GR3003324T3 (fi) |
| HU (1) | HU202231B (fi) |
| IE (1) | IE61122B1 (fi) |
| IL (1) | IL85564A (fi) |
| MW (1) | MW388A1 (fi) |
| MY (1) | MY103221A (fi) |
| NO (1) | NO174421C (fi) |
| NZ (1) | NZ223813A (fi) |
| PH (1) | PH25529A (fi) |
| PT (1) | PT86934B (fi) |
| ZA (1) | ZA881350B (fi) |
| ZW (1) | ZW2188A1 (fi) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5100867A (en) * | 1987-12-15 | 1992-03-31 | Siemens Aktiengesellschaft | Process for manufacturing wire or strip from high temperature superconductors and the sheaths used for implementing the process |
| GB9109557D0 (en) * | 1991-05-02 | 1991-06-26 | Wellcome Found | Chemical compounds |
| GB9611328D0 (en) * | 1996-05-31 | 1996-08-07 | Zeneca Ltd | Pharmaceutical compositions |
| GB9716161D0 (en) * | 1997-08-01 | 1997-10-08 | Zeneca Ltd | Process |
| GB9922271D0 (en) * | 1999-09-21 | 1999-11-17 | Zeneca Ltd | Formulation |
| IL164155A0 (en) * | 2002-03-20 | 2005-12-18 | Teva Pharma | Crystalline forms of quetiapine hemifumarate |
| KR100707050B1 (ko) | 2002-11-28 | 2007-04-13 | 에스케이 주식회사 | 10Ｈ-디벤조[ｂ,ｆ][1,4]티아제핀-11-온의 제조방법 |
| EP1495008A1 (en) * | 2003-02-22 | 2005-01-12 | Teva Pharmaceutical Industries Limited | Synthesis of quetiapine and pharmaceutically acceptable salts thereof |
| US7053115B2 (en) | 2003-04-07 | 2006-05-30 | Hetero Drugs Limited | Crystalline form of dorzolamide hydrochloride |
| ES2223294B2 (es) | 2003-08-08 | 2005-10-01 | Vita Cientifica, S.L. | Procedimiento de preparacion de un compuesto farmaceuticamente activo. |
| CA2538866A1 (en) * | 2003-09-23 | 2005-03-31 | Fermion Oy | Preparation of quetiapine |
| PL368245A1 (en) * | 2004-05-28 | 2005-12-12 | CELON PHARMA Sp.z o.o. | Method for manufacture of quetiapine |
| KR101038389B1 (ko) * | 2004-06-23 | 2011-06-01 | 에스케이바이오팜 주식회사 | 11-(4-[2-(2-히드록시에톡시)에틸]-1-피페라지닐)-디벤조[ｂ,ｆ][1,4]티아제핀의 제조방법 |
| GB0425729D0 (en) * | 2004-11-23 | 2004-12-22 | Pliva Res & Dev Ltd | Heterocyclic compounds |
| WO2006056772A2 (en) * | 2004-11-23 | 2006-06-01 | Pliva Hrvatska D.O.O. | Salts of quetiapine |
| EP1841751A1 (en) | 2005-01-24 | 2007-10-10 | IPCA Laboratories Limited | INDUSTRIAL PREPARATION OF 11-(4-(2-(2-HYDROXYETHOXY ETHYL)-1-PIPERAZINYL)DIBENZO (b,f)-1(1, 4)THIAZEPINE |
| ES2234447B1 (es) * | 2005-03-07 | 2006-03-01 | Union Quimico-Farmaceutica S.A. | Procedimiento para la obtencion de un derivado de 11-(4-sustituido-1-piperazinil)dibenzo(b,f)(1,4)tiazepina. |
| WO2006113425A1 (en) | 2005-04-14 | 2006-10-26 | Teva Pharmaceutical Industries Ltd. | Process for preparing quetiapine fumarate |
| WO2006135544A1 (en) * | 2005-06-10 | 2006-12-21 | Cambrex Charles City, Inc. | SYNTHESIS OF 11-(4[-(2-HYDROXYETHOXY)ETHYL]-PIPERAZINYL)-DIBENZO[b,f][1,4]THIAZEPINE AND ITS FUMARATE SALT |
| WO2007004234A1 (en) * | 2005-07-04 | 2007-01-11 | Usv Limited | A PROCESS FOR THE PREPARATION OF 2-[2-(4-DIBENZO[b,f] [L,4] THIAZEPIN-11-yl-1- PIPERAZINYL)ETHOXY] ETHANOL FUMARATE |
| GB0516603D0 (en) * | 2005-08-12 | 2005-09-21 | Sandoz Ag | Processes for the preparation of organic compounds useful as serotonin receptor antagonists |
| US8044039B2 (en) | 2005-10-28 | 2011-10-25 | Fermion Oy | Quetiapine hemifumarate purification by crystallization |
| PT103884A (pt) | 2006-11-17 | 2008-05-19 | Astrazeneca Ab | Composições de libertação prolongada e métodos para a sua preparação |
| US8420807B2 (en) | 2008-01-31 | 2013-04-16 | Fermion Oy | Process for the preparation of quetiapine |
| NZ590616A (en) | 2008-06-20 | 2012-09-28 | Astrazeneca Ab | Dibenzothiazepine derivatives and use thereof |
| DK2262486T3 (da) | 2008-08-01 | 2013-03-25 | Krka Tovarna Zdravil D D Novo Mesto | Quetiapin sammensætning |
| EP2153834A3 (en) | 2008-08-07 | 2010-02-24 | Farmaprojects, S.A. | Extended release pharmaceutical compositions comprising quetiapine salts |
| CN101676275B (zh) * | 2008-09-17 | 2014-05-07 | 北京德众万全药物技术开发有限公司 | 一种富马酸喹硫平的制备方法 |
| WO2010089259A2 (en) | 2009-02-04 | 2010-08-12 | Woerwag R&D Gmbh | Sustained release composition containing quetiapine |
| EP2403841A1 (en) | 2009-03-04 | 2012-01-11 | Ranbaxy Laboratories Limited | Process for the preparation of quetiapine fumarate |
| WO2011121602A1 (en) | 2010-03-29 | 2011-10-06 | Hikal Limited | Process for preparation of dibenzothiazepinone compounds |
| TR201008261A1 (tr) | 2010-10-08 | 2012-04-24 | Sanovel İlaç San. Ve Ti̇c. A.Ş. | Kontrollü salım gerçekleştiren ketiapin formülasyonları |
| EP2848244A1 (en) | 2013-09-16 | 2015-03-18 | Yildiz Özsoy Erginer | Extended release tablet formulations of quetiapine |
| CN103524455A (zh) * | 2013-10-30 | 2014-01-22 | 苏州敬业医药化工有限公司 | 一种制备2-氯-二苯并[b,f][1,4]硫氮杂卓-11-[10H]酮的方法 |
| CN104447615A (zh) * | 2014-02-28 | 2015-03-25 | 广东东阳光药业有限公司 | 喹硫平中间体的制备方法 |
| CN104016945B (zh) * | 2014-05-27 | 2016-06-29 | 渭南畅通药化科技有限公司 | 一种半富马酸喹硫平的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE792426A (fr) * | 1971-12-09 | 1973-06-07 | Wander Ag Dr A | Nouveaux derives de la dibenzo(b,f)(1,4)thiazepine, leur preparation etleur application comme medicaments |
| JPS60155171A (ja) * | 1983-12-10 | 1985-08-15 | Wako Pure Chem Ind Ltd | ポリメトキシベンジルピペラジン誘導体 |
| GB8607684D0 (en) * | 1986-03-27 | 1986-04-30 | Ici America Inc | Thiazepine compounds |
-
1987
- 1987-03-10 GB GB878705574A patent/GB8705574D0/en active Pending
-
1988
- 1988-02-22 GB GB888804063A patent/GB8804063D0/en active Pending
- 1988-02-24 IE IE50788A patent/IE61122B1/en not_active IP Right Cessation
- 1988-02-25 ZA ZA881350A patent/ZA881350B/xx unknown
- 1988-02-25 CA CA000559825A patent/CA1337345C/en not_active Expired - Lifetime
- 1988-02-26 MY MYPI88000197A patent/MY103221A/en unknown
- 1988-02-26 IL IL85564A patent/IL85564A/xx not_active IP Right Cessation
- 1988-02-29 AU AU12378/88A patent/AU595099B2/en not_active Ceased
- 1988-02-29 ZW ZW21/88A patent/ZW2188A1/xx unknown
- 1988-03-01 MW MW3/88A patent/MW388A1/xx unknown
- 1988-03-02 DK DK198801130A patent/DK175310B1/da not_active IP Right Cessation
- 1988-03-04 AT AT88301891T patent/ATE70271T1/de not_active IP Right Cessation
- 1988-03-04 ES ES198888301891T patent/ES2037822T3/es not_active Expired - Lifetime
- 1988-03-04 EP EP88301891A patent/EP0282236B1/en not_active Expired - Lifetime
- 1988-03-04 DE DE8888301891T patent/DE3866735D1/de not_active Expired - Lifetime
- 1988-03-07 PH PH36600A patent/PH25529A/en unknown
- 1988-03-07 HU HU881086A patent/HU202231B/hu unknown
- 1988-03-08 DD DD88313500A patent/DD271703A5/de unknown
- 1988-03-09 NZ NZ223813A patent/NZ223813A/en unknown
- 1988-03-09 FI FI881087A patent/FI87778C/fi not_active IP Right Cessation
- 1988-03-09 PT PT86934A patent/PT86934B/pt not_active IP Right Cessation
- 1988-03-09 AR AR88310264A patent/AR245707A1/es active
- 1988-03-09 NO NO881044A patent/NO174421C/no not_active IP Right Cessation
- 1988-03-10 KR KR1019880002483A patent/KR960007088B1/ko not_active IP Right Cessation
- 1988-03-10 JP JP63055092A patent/JPH0688991B2/ja not_active Expired - Lifetime
-
1991
- 1991-12-12 GR GR91400630T patent/GR3003324T3/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA1337345C (en) | Process for the preparation of a thiazepine compound | |
| US20060063927A1 (en) | Processes for preparing quetiapine and salts thereof | |
| EP1252151B1 (en) | A process for the preparation of quetiapine and intermediates therefor | |
| EP1781665A2 (en) | Olanzapine salts and their conversion to olanzapine free base | |
| WO2007004234A1 (en) | A PROCESS FOR THE PREPARATION OF 2-[2-(4-DIBENZO[b,f] [L,4] THIAZEPIN-11-yl-1- PIPERAZINYL)ETHOXY] ETHANOL FUMARATE | |
| KR20080108468A (ko) | 디벤조티아제핀 화합물의 제조 방법 | |
| RU2233275C2 (ru) | Способ получения производных дибензотиазепина | |
| EP1660468B1 (en) | Procedure for preparing 11-(4-[2-(2-hydroxyethoxy)ethyl]-1-piperazinyl)-dibenzo[b,f][1,4]thiazepine | |
| EP2245021B1 (en) | A process for the preparation of quetiapine | |
| US20120071649A1 (en) | Process for the preparation of quetiapine fumarate | |
| KR100241089B1 (ko) | 2-메르캅토-4-메틸-1,3-티아졸-5-아세트산의 신규한제조방법 | |
| EP0341562A1 (en) | Process for preparing(+)-and(-)-beta-[(2-amino-1-naphthalenyl)thio]-alpha-hydroxy-4-methoxy-benzenepropanoic acid | |
| JPS6078973A (ja) | １，５−ベンゾチアゼピン誘導体の製法 | |
| JPH11199574A (ja) | ジベンゾチアゼピン誘導体の製造方法 | |
| WO2008125518A2 (en) | Process for the preparation of piperazine benzothiazoles | |
| PL209897B1 (pl) | Sposób wytwarzania pochodnej dibenzotiazepiny |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry | ||
| MKEX | Expiry |
Effective date: 20121017 |