CA1312329C - Epipodophyllotoxin glucoside lactam derivatives - Google Patents

Epipodophyllotoxin glucoside lactam derivatives

Info

Publication number
CA1312329C
CA1312329C CA000590739A CA590739A CA1312329C CA 1312329 C CA1312329 C CA 1312329C CA 000590739 A CA000590739 A CA 000590739A CA 590739 A CA590739 A CA 590739A CA 1312329 C CA1312329 C CA 1312329C
Authority
CA
Canada
Prior art keywords
compound
phenyl
methyl
group
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA000590739A
Other languages
English (en)
French (fr)
Inventor
John F. Kadow
Dolatrai M. Vyas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of CA1312329C publication Critical patent/CA1312329C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CA000590739A 1988-02-16 1989-02-10 Epipodophyllotoxin glucoside lactam derivatives Expired - Fee Related CA1312329C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US15625388A 1988-02-16 1988-02-16
US156,253 1988-02-16
US302,010 1989-01-30
US07/302,010 US4958010A (en) 1988-02-16 1989-01-30 Epipodophyllotoxin glucoside lactam derivatives

Publications (1)

Publication Number Publication Date
CA1312329C true CA1312329C (en) 1993-01-05

Family

ID=26853009

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000590739A Expired - Fee Related CA1312329C (en) 1988-02-16 1989-02-10 Epipodophyllotoxin glucoside lactam derivatives

Country Status (4)

Country Link
US (1) US4958010A (OSRAM)
EP (1) EP0329108A3 (OSRAM)
JP (1) JPH01301689A (OSRAM)
CA (1) CA1312329C (OSRAM)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5523418A (en) * 1991-04-09 1996-06-04 Abbott Laboratories Macrocyclic lactam prokinetic agents
DK0579770T3 (da) * 1991-04-09 1996-11-04 Abbott Lab Makrocycliske lactamprokinetika
TW260671B (OSRAM) * 1991-04-29 1995-10-21 Bristol Myers Squibb Co
WO2001024763A2 (en) 1999-10-01 2001-04-12 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US6566393B1 (en) 2002-06-21 2003-05-20 The University Of North Carolina At Chapel Hill Etoposide analogs and methods of use thereof
US7176236B2 (en) 2002-06-21 2007-02-13 University Of North Carolina At Chapel Hill Water-soluble etoposide analogs and methods of use thereof
CA2673683C (en) 2007-01-11 2014-07-29 Critical Outcome Technologies, Inc. Compounds and method for treatment of cancer
US8138191B2 (en) 2007-01-11 2012-03-20 Critical Outcome Technologies Inc. Inhibitor compounds and cancer treatment methods
WO2009079797A1 (en) 2007-12-26 2009-07-02 Critical Outcome Technologies, Inc. Compounds and method for treatment of cancer
EP3235818A3 (en) 2010-04-01 2018-03-14 Critical Outcome Technologies, Inc. Compounds for the treatment of hiv
CN103080125A (zh) 2010-07-02 2013-05-01 安吉奥开米公司 用于治疗性结合物的短且含d氨基酸的多肽及其使用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH361293A (de) * 1957-06-03 1962-04-15 Sandoz Ag Verfahren zur Herstellung von Podophyllsäure- und Pikropodophyllsäure-Derivaten
GB1053339A (OSRAM) * 1963-03-29
NL6613143A (OSRAM) * 1965-09-21 1967-03-22
CH464957A (de) * 1965-12-14 1968-11-15 Sandoz Ag Verfahren zur Herstellung eines neuen Glucosids
EP0111058B1 (en) * 1982-11-26 1987-11-04 Nippon Kayaku Kabushiki Kaisha Process for producing 4'-demethyl-epipodophyllotoxin-beta-d-ethylidene-glucoside and acyl-derivative thereof

Also Published As

Publication number Publication date
JPH0577676B2 (OSRAM) 1993-10-27
US4958010A (en) 1990-09-18
EP0329108A3 (en) 1990-08-16
EP0329108A2 (en) 1989-08-23
JPH01301689A (ja) 1989-12-05

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