CA1272198A - 5,14-dihydrobenz[5,6]isoindolo[2,1-b] isoquinoline-8,13-dione - Google Patents

5,14-dihydrobenz[5,6]isoindolo[2,1-b] isoquinoline-8,13-dione

Info

Publication number
CA1272198A
CA1272198A CA000440383A CA440383A CA1272198A CA 1272198 A CA1272198 A CA 1272198A CA 000440383 A CA000440383 A CA 000440383A CA 440383 A CA440383 A CA 440383A CA 1272198 A CA1272198 A CA 1272198A
Authority
CA
Canada
Prior art keywords
compound
formula
pharmaceutical composition
crystalline
process comprises
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA000440383A
Other languages
English (en)
French (fr)
Inventor
Gordon Hanley Phillipps
Stanley Frederick Dyke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of CA1272198A publication Critical patent/CA1272198A/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
CA000440383A 1982-11-04 1983-11-03 5,14-dihydrobenz[5,6]isoindolo[2,1-b] isoquinoline-8,13-dione Expired - Fee Related CA1272198A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8231540 1982-11-04
GB8231540 1982-11-04

Publications (1)

Publication Number Publication Date
CA1272198A true CA1272198A (en) 1990-07-31

Family

ID=10534035

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000440383A Expired - Fee Related CA1272198A (en) 1982-11-04 1983-11-03 5,14-dihydrobenz[5,6]isoindolo[2,1-b] isoquinoline-8,13-dione

Country Status (20)

Country Link
US (1) US4831039A (no)
EP (1) EP0108620B1 (no)
JP (1) JPS5998084A (no)
KR (1) KR900008697B1 (no)
AT (1) ATE25256T1 (no)
AU (1) AU566898B2 (no)
CA (1) CA1272198A (no)
DE (1) DE3369515D1 (no)
DK (1) DK158666C (no)
ES (1) ES526995A0 (no)
FI (1) FI74003C (no)
GB (1) GB2129799B (no)
GR (1) GR78749B (no)
IE (1) IE56206B1 (no)
IL (1) IL70124A (no)
NO (1) NO159933C (no)
NZ (1) NZ206141A (no)
PH (1) PH19013A (no)
PT (1) PT77601B (no)
ZA (1) ZA838237B (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK158666C (da) * 1982-11-04 1990-11-19 Glaxo Group Ltd Analogifremgangsmaade til fremstilling af 5,14-dihydrobenz-oe5,6aa-isoindolooe2,1-baa-isoquinolin-8,13-dion
EP0161102B1 (en) * 1984-05-03 1990-02-21 Glaxo Group Limited Isoquinoline derivatives
GB8513460D0 (en) * 1985-05-29 1985-07-03 Glaxo Group Ltd Chemical compounds
NO872963L (no) * 1986-07-29 1988-02-01 Glaxo Group Ltd Isokinolinderivater.
DK616087A (da) * 1986-11-27 1988-05-28 Glaxo Group Ltd Isoquinolinderivater og farmaceutiske praeparater indeholdende dem
GB8800312D0 (en) * 1988-01-07 1988-02-10 Glaxo Group Ltd Process

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4042591A (en) * 1973-05-30 1977-08-16 Sandoz Ltd. Naphthoquinone compounds
FR2387229A1 (fr) * 1977-04-13 1978-11-10 Anvar Dipyrido (4,3-b) (3,4-f) indoles, procede d'obtention, application therapeutique et compositions pharmaceutiques les contenant
FR2436786A1 (fr) * 1978-09-21 1980-04-18 Anvar Nouveaux derives des pyrido (4,3-b) carbazoles (ellipticines), substitues en position 1 par une chaine polyaminee, leur obtention et leur application a titre de medicaments
DK158666C (da) * 1982-11-04 1990-11-19 Glaxo Group Ltd Analogifremgangsmaade til fremstilling af 5,14-dihydrobenz-oe5,6aa-isoindolooe2,1-baa-isoquinolin-8,13-dion
EP0161102B1 (en) * 1984-05-03 1990-02-21 Glaxo Group Limited Isoquinoline derivatives

Also Published As

Publication number Publication date
FI74003C (fi) 1987-12-10
DK499583D0 (da) 1983-11-01
ATE25256T1 (de) 1987-02-15
AU566898B2 (en) 1987-11-05
EP0108620B1 (en) 1987-01-28
IL70124A (en) 1986-11-30
JPS5998084A (ja) 1984-06-06
DK158666C (da) 1990-11-19
GB2129799A (en) 1984-05-23
EP0108620A1 (en) 1984-05-16
NO834019L (no) 1984-05-07
AU2096683A (en) 1984-05-10
IL70124A0 (en) 1984-02-29
PT77601A (en) 1983-12-01
KR900008697B1 (ko) 1990-11-27
US4831039A (en) 1989-05-16
FI834045A0 (fi) 1983-11-03
NO159933C (no) 1989-02-22
NO159933B (no) 1988-11-14
KR840006657A (ko) 1984-12-01
PH19013A (en) 1985-12-03
GB2129799B (en) 1986-02-26
PT77601B (en) 1986-03-18
ES8504796A1 (es) 1985-04-16
FI74003B (fi) 1987-08-31
DE3369515D1 (de) 1987-03-05
ES526995A0 (es) 1985-04-16
IE832575L (en) 1984-05-04
GB8329342D0 (en) 1983-12-07
DK158666B (da) 1990-07-02
DK499583A (da) 1984-05-05
JPS6225668B2 (no) 1987-06-04
IE56206B1 (en) 1991-05-22
ZA838237B (en) 1984-11-28
NZ206141A (en) 1986-09-10
GR78749B (no) 1984-10-02
FI834045A (fi) 1984-05-05

Similar Documents

Publication Publication Date Title
DE69412251T2 (de) Aromatische nitro verbindungen und deren metabolite verwendbar als anti-virus-und anti-tumormittel
CA1280369C (en) Pharmaceutical with anti-tumor effect
CA1049515A (en) Derivatives of 1,7-dihydro-2h-pyrazolo (4',3':5,6) -pyrido(4,3-d) pyrimidine-2,4-(3h)-diones
KR20030022371A (ko) 벤질리덴아미노구아니딘 및 히드록시구아니딘의멜라노코르틴 수용체 리간드로서의 용도
CA1272198A (en) 5,14-dihydrobenz[5,6]isoindolo[2,1-b] isoquinoline-8,13-dione
WO2021121210A1 (zh) 并环类衍生物、其制备方法及其在医药上的应用
CA1060003A (en) N-trifluoroacetyladriamycin-14-alkanoates and therapeutic compositions containing same
AU585936B2 (en) Pharmaceutically active podophyllotoxins
US5036103A (en) Method of treating cancer cells in humans
CN101817761A (zh) 苯甲酸酯类衍生物及制备方法和应用
JPS61501986A (ja) パンクラチスタチン
JPH11513040A (ja) モルホリニルアントラサイクリン誘導体
CN107216362A (zh) 一种阿糖胞苷两亲性小分子前药及其制备方法和应用
US4479957A (en) Use of vindesine in treating acute lymphatic leukemia and _other susceptible neoplasms
CN107216283A (zh) 一种含有二氢吡啶结构的β－榄香烯衍生物及其制备方法和用途
DE60012750T2 (de) Neue xanthon derivate, deren herstellung und verwendung als arzneimittel
CN104098645B (zh) 一类熊果酸吲哚衍生物、制备方法及其用途
JP2724493B2 (ja) ５−メトキシトリプタミン及びトリプタミン誘導体の合成方法
DE69128788T2 (de) 1,2-dihydro-3h-dibenzoisochinolin-1,3-dione als antitumormittel
US6037357A (en) N-benzoyl-α-alkylated azatyrosines as anticancer agents
KR20230157471A (ko) 화합물의 다형체 및 이의 제조방법과 용도
CN104402894B (zh) 3-（1-烷氧乙基）二氢卟吩e6类似物的金属络合物及其制备方法和应用
DE3880231T2 (de) Pyrazinoxid-Verbindung aus NF-1616-904, diese enthaltende Arzneimittelzubereitung und Verfahren zu ihrer Herstellung.
WO2021123928A1 (en) Deuterated analogues of selenophenochromenes, synthesis thereof, and methods of using same agents
CN102816082A (zh) 苯甲酰胺类衍生物及制备方法和应用

Legal Events

Date Code Title Description
MKLA Lapsed