CA1262908A - Pyrrolobenzimidazoles, process for the preparation thereof and pharmaceutical compositions containing them - Google Patents

Pyrrolobenzimidazoles, process for the preparation thereof and pharmaceutical compositions containing them

Info

Publication number
CA1262908A
CA1262908A CA000497668A CA497668A CA1262908A CA 1262908 A CA1262908 A CA 1262908A CA 000497668 A CA000497668 A CA 000497668A CA 497668 A CA497668 A CA 497668A CA 1262908 A CA1262908 A CA 1262908A
Authority
CA
Canada
Prior art keywords
compound
radical
formula
amino
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
CA000497668A
Other languages
English (en)
French (fr)
Inventor
Alfred Mertens
Jens-Peter Holck
Wolfgang Kampe
Bernd Muller-Beckmann
Klaus Strein
Wolfgang Schaumann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Application granted granted Critical
Publication of CA1262908A publication Critical patent/CA1262908A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA000497668A 1984-12-14 1985-12-13 Pyrrolobenzimidazoles, process for the preparation thereof and pharmaceutical compositions containing them Expired CA1262908A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP3445669.4 1984-12-14
DE19843445669 DE3445669A1 (de) 1984-12-14 1984-12-14 Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Publications (1)

Publication Number Publication Date
CA1262908A true CA1262908A (en) 1989-11-14

Family

ID=6252801

Family Applications (1)

Application Number Title Priority Date Filing Date
CA000497668A Expired CA1262908A (en) 1984-12-14 1985-12-13 Pyrrolobenzimidazoles, process for the preparation thereof and pharmaceutical compositions containing them

Country Status (16)

Country Link
US (2) US4710510A (enExample)
EP (1) EP0186010B1 (enExample)
JP (1) JPS61158984A (enExample)
AT (1) ATE49970T1 (enExample)
AU (1) AU580822B2 (enExample)
CA (1) CA1262908A (enExample)
CS (1) CS276403B6 (enExample)
DD (1) DD242045A5 (enExample)
DE (2) DE3445669A1 (enExample)
DK (1) DK579185A (enExample)
ES (1) ES8702409A1 (enExample)
FI (1) FI79318C (enExample)
GR (1) GR852979B (enExample)
HU (1) HU194241B (enExample)
SU (1) SU1440348A3 (enExample)
ZA (1) ZA859382B (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3501497A1 (de) * 1985-01-18 1986-07-24 Boehringer Mannheim Gmbh, 6800 Mannheim Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
DE3531678A1 (de) * 1985-09-05 1987-03-12 Boehringer Mannheim Gmbh Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3626664A1 (de) * 1986-08-07 1988-02-11 Boehringer Mannheim Gmbh Tricyclische benzotriazole, verfahren zu ihrer herstellung sowie arzneimittel
DE3639466A1 (de) * 1986-11-18 1988-05-19 Thomae Gmbh Dr K Neue pyrrolo-benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3642315A1 (de) * 1986-12-11 1988-06-23 Boehringer Mannheim Gmbh Neue pyrrolobenzimidazole, verfahren zu ihrer herstellung sowie arzneimittel
DE3701277A1 (de) * 1987-01-17 1988-07-28 Boehringer Mannheim Gmbh Neue tricyclische benzimidazole, verfahren zu ihrer herstellung und verwendung als arzneimittel
DE3740985A1 (de) * 1987-12-03 1989-06-15 Boehringer Mannheim Gmbh Verwendung linear anellierter tricyclen als hemmer der erythrozytenaggregation
ATE138658T1 (de) * 1987-12-30 1996-06-15 Orion Yhtymae Oy Heterocyclische verbindungen
US4963677A (en) * 1987-12-30 1990-10-16 Orion Corporation Ltd. Heterocyclic lactam compounds
DE3803775A1 (de) * 1988-02-09 1989-08-17 Boehringer Mannheim Gmbh Neue substituierte lactame, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
DE4027592A1 (de) * 1990-08-31 1992-03-05 Beiersdorf Ag Neue pyrrolobenzimidazole, imidazobenzoxazinone und imidazochinolone, verfahren zu ihrer herstellung und ihre verwendung sowie die verbindungen enthaltende zubereitungen
US7186745B2 (en) * 2001-03-06 2007-03-06 Astrazeneca Ab Indolone derivatives having vascular damaging activity
US6951848B2 (en) * 2001-03-12 2005-10-04 Millennium Pharmaceuticals, Inc., Functionalized heterocycles as modulators of chemokine receptor function and methods of use therefor
US20050165028A1 (en) * 2004-01-23 2005-07-28 Norman Mark H. Vanilloid receptor ligands and their use in treatments
WO2014040969A1 (en) 2012-09-13 2014-03-20 F. Hoffmann-La Roche Ag 2-oxo-2,3-dihydro-indoles for the treatment of cns disorders
ES2896400T3 (es) 2014-08-01 2022-02-24 Nuevolution As Compuestos activos frente a bromdominios
GB201709456D0 (en) * 2017-06-14 2017-07-26 Ucb Biopharma Sprl Therapeutic agents

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4234571A (en) * 1979-06-11 1980-11-18 Syntex (U.S.A.) Inc. Nonapeptide and decapeptide derivatives of luteinizing hormone releasing hormone
EP0033612B1 (en) * 1980-02-02 1984-04-11 Beecham Group Plc Pyrano derivatives, a process for their preparation and antihypertensive compositions containing them
FR2476644A1 (fr) * 1980-02-21 1981-08-28 Sarget Lab Orthoarylydeneaminophenethylamine, leur preparation et leur utilisation therapeutique
DE3224512A1 (de) * 1982-07-01 1984-01-05 Dr. Karl Thomae Gmbh, 7950 Biberach Neue imidazolderivate, ihre herstellung und diese verbindungen enthaltende arzneimittel
SU1068439A1 (ru) * 1982-10-28 1984-01-23 Новокузнецкий научно-исследовательский химико-фармацевтический институт Производные имидазо(4,5- @ ) индолов
US4579865A (en) * 1983-02-14 1986-04-01 Usv Pharmaceutical Corp. Benzofuranyl carbamates
US4548943A (en) * 1984-05-11 1985-10-22 E. I. Du Pont De Nemours And Company Antiinflammatory, analgesic, or anti-primary dysmenorrheal arylmethylene- and arylmethylindenoimidazoles
GR851085B (enExample) * 1984-05-12 1985-11-25 Boehringer Mannheim Gmbh
DE3501497A1 (de) * 1985-01-18 1986-07-24 Boehringer Mannheim Gmbh, 6800 Mannheim Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
DE3531678A1 (de) * 1985-09-05 1987-03-12 Boehringer Mannheim Gmbh Neue pyrrolo-benzimidazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
FI854926A0 (fi) 1985-12-12
AU580822B2 (en) 1989-02-02
EP0186010A1 (de) 1986-07-02
ES549776A0 (es) 1987-01-16
DK579185A (da) 1986-06-15
SU1440348A3 (ru) 1988-11-23
FI79318C (fi) 1989-12-11
ATE49970T1 (de) 1990-02-15
DK579185D0 (da) 1985-12-13
EP0186010B1 (de) 1990-01-31
ZA859382B (en) 1986-08-27
HUT40436A (en) 1986-12-28
JPH0471914B2 (enExample) 1992-11-16
AU5100685A (en) 1986-06-19
FI79318B (fi) 1989-08-31
US4710510A (en) 1987-12-01
GR852979B (enExample) 1986-04-08
DD242045A5 (de) 1987-01-14
CS276403B6 (en) 1992-05-13
HU194241B (en) 1988-01-28
DE3445669A1 (de) 1986-06-19
DE3575725D1 (de) 1990-03-08
FI854926A7 (fi) 1986-06-15
JPS61158984A (ja) 1986-07-18
US4810801A (en) 1989-03-07
ES8702409A1 (es) 1987-01-16
CS919585A3 (en) 1992-01-15

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Legal Events

Date Code Title Description
MKLA Lapsed